Academic literature on the topic 'Amyotrophic lateral sclerosis RNA Messenger RNA Superoxide dismutase'

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Journal articles on the topic "Amyotrophic lateral sclerosis RNA Messenger RNA Superoxide dismutase"

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Thomas, Eleanor V., Wayne A. Fenton, James McGrath, and Arthur L. Horwich. "Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice." Proceedings of the National Academy of Sciences 114, no. 15 (2017): E3139—E3148. http://dx.doi.org/10.1073/pnas.1701465114.

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Recent studies have reported spread of pathogenic proteins in the mammalian nervous system, but whether nonpathogenic ones spread is unknown. We initially investigated whether spread of a mutant amyotrophic lateral sclerosis-associated cytosolic superoxide dismutase 1 (SOD1) protein between motor neurons could be detected in intact chimeric mice. Eight-cell embryos from G85R SOD1YFP and G85R SOD1CFP mice were aggregated, and spinal cords of adult chimeric progeny were examined for motor neurons with cytosolic double fluorescence. By 3 mo of age, we observed extensive double fluorescence, inclu
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Volkening, Kathryn, Cheryl Leystra-Lantz, Wenchang Yang, Howard Jaffee, and Michael J. Strong. "Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)." Brain Research 1305 (December 2009): 168–82. http://dx.doi.org/10.1016/j.brainres.2009.09.105.

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Leoni, Emanuela, Michael Bremang, Vikram Mitra, et al. "Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis." Scientific Reports 9, no. 1 (2019). http://dx.doi.org/10.1038/s41598-019-40632-4.

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Abstract The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment response has hampered the development of new therapies for amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disorder with a variable site of disease initiation and rate of progression. To identify new biomarkers and therapeutic targets, two separate proteomic workflows were applied to study the immunological response and the plasma/brain proteome in phenotypic variants of ALS. Conventional multiplex (TMT) proteomic analysis of peripheral blood mononuclear cells
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Dissertations / Theses on the topic "Amyotrophic lateral sclerosis RNA Messenger RNA Superoxide dismutase"

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Chang, Yueming. "Investigation of two early events in amyotrophic lateral sclerosis mRNA oxidation and up-regulation of a novel protective factor MSUR1 /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1196182155.

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Likhite, Shibi B. "Therapeutic suppression of mutant SOD1 by AAV9-mediated gene therapy approach in Amyotrophic Lateral Sclerosis." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417394084.

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