Relevant bibliographies by topics / Amyotrophic lateral sclerosis, stem cells, extracellular vesicles, MRI

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Amyotrophic lateral sclerosis, stem cells, extracellular vesicles, MRI'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Amyotrophic lateral sclerosis, stem cells, extracellular vesicles, MRI"

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Provenzano, Francesca, Sophie Nyberg, Debora Giunti, et al. "Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS." Cells 11, no. 23 (2022): 3923. http://dx.doi.org/10.3390/cells11233923.

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure. Astrocytes display a toxic phenotype in ALS and contribute to motoneuron (MN) degeneration. Modulating astrocytes’ neurotoxicity can reduce MN death. Our previous studies showed the beneficial effect of mesenchymal stem cell (MSC) administration in SOD1G93A ALS mice, but the mechanisms are still unclear. We postulated that the effects could be mediated by extracellular vesicles (EVs) secreted by MSCs. We investigated, by immunohistochemical, molecular, and in vitro functional analyses, the activity of MS
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McCluskey, Gavin, Karen E. Morrison, Colette Donaghy, Frederique Rene, William Duddy, and Stephanie Duguez. "Extracellular Vesicles in Amyotrophic Lateral Sclerosis." Life 13, no. 1 (2022): 121. http://dx.doi.org/10.3390/life13010121.

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Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disease and is the most common adult motor neuron disease. The disease pathogenesis is complex with the perturbation of multiple pathways proposed, including mitochondrial dysfunction, RNA processing, glutamate excitotoxicity, endoplasmic reticulum stress, protein homeostasis and endosomal transport/extracellular vesicle (EV) secretion. EVs are nanoscopic membrane-bound particles that are released from cells, involved in the intercellular communication of proteins, lipids and genetic material, and there is increasing evidence of
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Afonso, Gonçalo J. M., Carla Cavaleiro, Jorge Valero, Sandra I. Mota, and Elisabete Ferreiro. "Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives." Cells 12, no. 13 (2023): 1763. http://dx.doi.org/10.3390/cells12131763.

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Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs’ formation and cargo ca
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Yang, Junzheng. "Stem Cells Applications in Neurodegenerative Diseases." Epidemiology International Journal 7, no. 4 (2023): 1–6. http://dx.doi.org/10.23880/eij-16000267.

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Neurodegenerative diseases are a kind of diseases caused by progressive loss of neuronal structure and function and glial cell homeostasis imbalance, there are many kinds of neurodegenerative diseases include Alzheimer's disease (AD), Parkinson's disease (PD); Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). So far, due to the lack of ideal treatment methods, it seriously threats to human health especially the elder population. Recently, with the rapid development of regenerative medicine, stem cells rely on their advantages including self-renewing capability, low immunogenic
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Ore, Adaleiz, James M. Angelastro, and Cecilia Giulivi. "Integrating Mitochondrial Biology into Innovative Cell Therapies for Neurodegenerative Diseases." Brain Sciences 14, no. 9 (2024): 899. http://dx.doi.org/10.3390/brainsci14090899.

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The role of mitochondria in neurodegenerative diseases is crucial, and recent developments have highlighted its significance in cell therapy. Mitochondrial dysfunction has been implicated in various neurodegenerative disorders, including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and Huntington’s diseases. Understanding the impact of mitochondrial biology on these conditions can provide valuable insights for developing targeted cell therapies. This mini-review refocuses on mitochondria and emphasizes the potential of therapies leveraging mesenchymal stem cells, embryonic stem cel
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Kandeel, Mahmoud, Mohamed A. Morsy, Khalid M. Alkhodair, and Sameer Alhojaily. "Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities." Biomolecules 13, no. 8 (2023): 1250. http://dx.doi.org/10.3390/biom13081250.

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Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of biologically active elements, making them a promising approach for therapeutics and diagnostics. This article examines the potential therapeutic applications of MSC-derived EVs in addressing neurodegenerative disorders such as Alzheimer’s disease (AD), multiple sclerosis (MS), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). Furthermore, the present state-of-the-art for
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Vassileff, Natasha, Lesley Cheng, and Andrew F. Hill. "Extracellular vesicles – propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases." Journal of Cell Science 133, no. 23 (2020): jcs243139. http://dx.doi.org/10.1242/jcs.243139.

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ABSTRACTNeurodegenerative diseases are characterised by the irreversible degeneration of neurons in the central or peripheral nervous systems. These include amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases. Small extracellular vesicles (sEVs), a type of EV involved in cellular communication, have been well documented as propagating neurodegenerative diseases. These sEVs carry cargo, such as proteins and RNA, to recipient cells but are also capable of promoting protein misfolding, thus actively contributing to the progression of these di
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8

Dabrowska, Sylwia, Ermanna Turano, Ilaria Scambi, et al. "A Cellular Model of Amyotrophic Lateral Sclerosis to Study the Therapeutic Effects of Extracellular Vesicles from Adipose Mesenchymal Stem Cells on Microglial Activation." International Journal of Molecular Sciences 25, no. 11 (2024): 5707. http://dx.doi.org/10.3390/ijms25115707.

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of upper and lower motor neurons (MNs) in the brain and spinal cord, leading to progressive paralysis and death. Increasing evidence indicates that neuroinflammation plays an important role in ALS’s pathogenesis and disease progression. Neuroinflammatory responses, primarily driven by activated microglia and astrocytes, and followed by infiltrating peripheral immune cells, contribute to exacerbate/accelerate MN death. In particular, the role of the microglia in ALS remains unc
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Bonafede, Roberta, Ermanna Turano, Ilaria Scambi, et al. "ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS." International Journal of Molecular Sciences 21, no. 10 (2020): 3651. http://dx.doi.org/10.3390/ijms21103651.

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motoneurons. To date, there is no effective treatment available. Exosomes are extracellular vesicles that play important roles in intercellular communication, recapitulating the effect of origin cells. In this study, we tested the potential neuroprotective effect of exosomes isolated from adipose-derived stem cells (ASC-exosomes) on the in vivo model most widely used to study ALS, the human SOD1 gene with a G93A mutation (SOD1(G93A)) mouse. Moreover, we compared the effect of t
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Bonafede, Brandi, Manfredi, et al. "The Anti-Apoptotic Effect of ASC-Exosomes in an In Vitro ALS Model and Their Proteomic Analysis." Cells 8, no. 9 (2019): 1087. http://dx.doi.org/10.3390/cells8091087.

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Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell based therapy. We demonstrated that exosomes isolated from adipose stem cells (ASC) display a neuroprotective role in an in vitro model of ALS. Moreover, the internalization of ASC-exosomes by the cells was shown and the molecules and the mechanisms by which exosomes could exert th
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Dissertations / Theses on the topic "Amyotrophic lateral sclerosis, stem cells, extracellular vesicles, MRI"

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Bonafede, Roberta. "Exosomes from mesenchymal stem cells: experimental assessment of an innovative therapeutic approach for ALS." Doctoral thesis, 2016. http://hdl.handle.net/11562/939082.

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La sclerosi laterale amiotrofica (SLA) è una patologia neurodegenerativa progressiva caratterizzata da progressiva paralisi muscolare e degenerazione dei motoneuroni nella corteccia motoria primaria, tronco encefalico e midollo spinale. Mutazioni nel gene superossido dismutasi 1 (SOD1) rappresentano uno dei maggiori contributi genetici di SLA. Diverse strategie terapeutiche sono state testate in modelli in-vitro e in-vivo della patologia, ma al momento non esiste trattamento in grado di curare o di migliorare la qualità di vita dei pazienti. Le cellule staminali rappresentano un approccio tera
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