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Dissertations / Theses on the topic 'AmyTan'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Shultz, Rebekah Elizabeth. "The role of Taoism in the social construction of identity in The Joy Luck Club." CSUSB ScholarWorks, 2002. https://scholarworks.lib.csusb.edu/etd-project/2060.

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2

Huang, Xiaofang. "Functional study of amylin and regulation of amylin receptor." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/114036.

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Pharmacology<br>Ph.D.<br>Amylin, a 37 amino acid peptide secreted from pancreatic beta cells upon stimulation by meal/glucose, belongs to the family of the calcitonin or calcitonin gene-related peptide (CGRP) and shares up to 50% homology with CGRP, which is a well-documented pain-related peptide. The amylin receptor is composed of a calcitonin receptor (CTR) and receptor activity modifying proteins (RAMPs). Numerous studies have shown that amylin plays an important role in glucose homeostasis and food intake. Few studies have been conducted with respect to the effect of amylin in the central

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3

Liu, Zhihong. "Structural analysis of amylin and its analogs by NMR spectroscopy /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8657.

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4

Allsop, Ben. "The role of amylin in Alzheimer's disease." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-amylin-in-alzheimers-disease(0667f0c6-8621-4a0b-b9ab-10d3d3730cd2).html.

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Type II diabetes mellitus (T2D) and Alzheimer's disease (AD) share aetiology and have a high incidence of co-morbidity. Evidence suggests that both diseases are caused by the pathogenic aggregation of an intrinsically disordered native amyloid peptide. Furthermore, T2D and AD share risk factors such as age, obesity and vascular health. Recent studies demonstrate that amylin, an amyloidogenic pancreatic hormone deposited in the pancreas in T2D, is also deposited in the brain in AD. We hypothesised that amylin directly contributes to AD through deposition in the brain and activation of pathogeni

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5

Botes, Frans Hendrik. "Ant tree miner amyntas for intrusion detection." Thesis, Cape Peninsula University of Technology, 2018. http://hdl.handle.net/20.500.11838/2865.

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Thesis (MTech (Information Technology))--Cape Peninsula University of Technology, 2018.<br>With the constant evolution of information systems, companies have to acclimatise to the vast increase of data flowing through their networks. Business processes rely heavily on information technology and operate within a framework of little to no space for interruptions. Cyber attacks aimed at interrupting business operations, false intrusion detections and leaked information burden companies with large monetary and reputational costs. Intrusion detection systems analyse network traffic to identify susp

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6

Bouwer, Maria S. (Maria Susanna). "EEG during the intracarotid sodium Amytal test : quantification and relationship to memory, sensory, and motor functions." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60546.

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The intracarotid sodium Amytal test determines whether each hemisphere can sustain memory, presumably mediated by the hippocampus, on its own. Scepticism exists, however, about its validity because the hippocampus may not be completely irrigated by the internal carotid artery. EEG analysis in patients having intracerebral electrodes showed the hippocampus to be clearly affected. To ensure that memory is tested only during Amytal inactivation, monitoring the duration of inactivation is necessary. It was found that EEG measures predicted a significantly shorter duration than motor and sensory me

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7

Tomlinson, Ann E. "Characterisation of calcitonin gene-related peptide (CGRP) and amylin receptors." Thesis, Aston University, 1995. http://publications.aston.ac.uk/14312/.

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The aims of this study were to examine the binding characteristics of the rat CGRP receptor and to further the classification of CGRP and amylin receptors in guinea-pig tissue preparations. Binding characteristics of CGRP were investigated on rat splenic, cerebellar and liver membrane preparations. Human-a-CGRP, rat-a-CGRP and the CGRP receptor analogues TyrO -CGRPC28-37) and [Cys (ACMh,7 ]-human CGRP and the CGRP receptor antagonist CGRPC8-37) were utilised in competitive radioligand binding experiments to identify possible CGRP receptor subtypes in these tissues. There appeared to be no sign

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8

AragÃo, Gislei Frota. "Antiinflammatory, antiaggregant activity and central effects of alpha and beta amyrin from protium heptaphyllum Aubl March." Universidade Federal do CearÃ, 2004. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=35.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>The species Protium heptaphyllum Aubl. March. belonging to the family Burseraceae is common in several areas of Brazil, where is known as almecega or white pitch. The plant is used popularly an anti-inflammatory and antiulcer. The objective of the present work was to study the pharmacological effects of a isomeric mixture of two triterpenes: alpha and beta amyrin (AMI) isolated from Protium heptaphyllum. The pharmacological activities (antinociceptive, antiedematogenic, central and antiaggregant), of AMI were studied in mice, usi

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9

Yang, Fan. "Amylin mediates brainstem control of heart rate in the diving reflex." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/193415.

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Pharmacology<br>Ph.D.<br>Amylin, or islet amyloid polypeptide is a 37-amino acid member of the calcitonin peptide family. Amylin role in the brainstem and its function in regulating heart rates is unknown. The diving reflex is a powerful autonomic reflex, however no neuropeptides have been described to modulate its function. In this thesis study, amylin expression in the brainstem involving pathways between the trigeminal ganglion and the nucleus ambiguus was visualized and characterized using immunohistochemistry. Its functional role in slowing heart rate and also its involvement in the divin

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10

Lee, Shao Chin. "Isolation and characterisation of two amylin responsive proteins from rat skeletal muscle." Thesis, University of Auckland, 1997. http://hdl.handle.net/2292/1901.

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Two amylin responsive proteins, here designated ARP1 and ARP2, were discovered from rat skeletal muscle through two dimensional gel electrophoresis analysis. ARP1 was detected only in amylin-stimulated muscles where the insulin-stimulated glucose incorporation into glycogen was inhibited. This protein incorporated 32Pi but not [35S]-methionine in the metabolic labeling experiments. Subsequent molecular characterisation revealed that ARP1 was a novel monomeric form (designated form 1) of protein p20, and two other monomeric forms (designated forms 2 and 3 respectively) of protein p20 were also

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11

Foot, Elizabeth Anne. "The role of amylin and calcitonin gene-related peptide in skeletal muscle." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334273.

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12

Cooper, Garth J. S. "The characterisation of amylin and analysis of its role in diabetes mellitus." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303042.

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13

Hoyer, Frank. "Strukturaufklärung des C-19-C-29-Fragmentes von Amycin B sowie von Sibyllimycin." [S.l. : s.n.], 1998. http://deposit.ddb.de/cgi-bin/dokserv?idn=954824806.

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14

Velander, Paul William. "Discovery and Mechanisms of Small Molecule Amyloid Formation Inhibitors." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/81837.

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Current dogma suggests modulating or preventing amyloid assembly will prove critical to the armamentarium of therapeutic interventions that will likely be required to overcome the multifaceted pathology associated with amyloid diseases. The work described in this dissertation reveals substantial gains in understanding key aspects relating to the anti-amylin amyloid activities associated with both individual and broad groups of small molecule amyloid inhibitors. A main observation was the important role that the catechol functional group plays in modulating and preventing amyloid formation. I

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15

Amyan, Adham [Verfasser], Jens [Akademischer Betreuer] Müller, and Michael [Akademischer Betreuer] Lang. "Elektronische und magnetische Phasenseparation in EuB6 : Fluktuationsspektroskopie und nichtlinearer Transport / Adham Amyan. Gutachter: Jens Müller ; Michael Lang. Betreuer: Jens Müller." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2013. http://d-nb.info/1044094389/34.

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16

Trikha, Saurabh. "Unraveling the Molecular Mechanisms of Human Amylin Binding, Turnover and Toxicity in Pancreatic Cells." Thesis, The George Washington University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3590360.

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<p> Islet amyloid polypeptide or amylin is a recently discovered 37 amino acid residue signaling protein (hormone) that is produced and co-secreted along with insulin by pancreatic beta-cells. In late onset of diabetes, amylin readily aggregates forming protein deposits or plaques that are toxic to beta-cells, resulting in beta-cell apoptosis. Given the well-known role of cholesterol and lipids in etiology of diabetes, I explored whether these two essential PM components regulate amylin assembly and aggregation on artificial (synthetic) membranes. Using high resolution imaging and spectroscopi

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17

Cohanoschi, Mihaela. "Part I: Evaluation of Russian Synthetic Compounds as a Potential Source of New Drug Leads Agains Breast and Colon Cancer Part II: Isolation of Beta-Amyrin Formate From Eucalyptus Viminalis Labill and Investigation of its Colon Cancer Activity." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4144.

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Although modern medicine made great steps toward curing most diseases considered deadliest, yet cancer remains one of the major public health problems. The first part of this thesis investigates a new source of selective compounds that are potential candidates against cancer. Fifteen Russian compounds were tested in order to establish their efficiency against two types of cancer: human breast SK-Br-3 and colorectal carcinoma HT-29. The bioassay results show that seven of the new synthetic Russian compounds can be considered new drug leads, based upon their low toxicity and efficacy in slowing

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18

Obasse, Idira Christopher. "Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes." Thesis, Lancaster University, 2017. http://eprints.lancs.ac.uk/88763/.

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Human islet amyloid polypeptide (hIAPP), also known as amylin, is the main constituent of the amyloid deposits present in approximately 95% of people with type 2 diabetes. Amylin aggregates into oligo-/polymeric sheet structures which are considered to be cytotoxic to pancreatic -cells. Inhibiting the early stages of amylin aggregation could provide a potential therapeutic strategy for the treatment of type 2 diabetes. In this study, overlapping peptides were designed to target the binding region (RLANFLVHSS, residues 11-20) of human amylin and their effects on amylin fibril formation were stu

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19

Kairamkonda, Venkatesh. "Amylin peptide : an association with feed intolerance in preterm neonates and infants of diabetic mothers." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/2893/.

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Title: Amylin peptide: An association with feed intolerance in preterm neonates and infants of diabetic mothers Introduction: Delayed enteral nutrition due to feed intolerance is common in preterm infants and infants of mothers whose pregnancy was complicated by diabetes mellitus (IMDM). Amylin, a 37 amino-acid polypeptide hormone, is a potent inhibitor of gastric emptying that may play a role in the patho-physiology of feed intolerance in these infants. Aims and Objectives: To determine serum amylin levels (i) at birth (umbilical cord) and postnatal day 5 (Guthrie) in healthy preterm and term

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20

Trikalinou, Anna. "AMYNA: A Security Generator and Performance Estimator Framework Against Memory-Based Attacks." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1418998019.

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21

Klein, Elissandro Jair. "Obtenção de compostos bioativos de folhas de uvaia (Eugenia pyriformis Cambess.) utilizando CO2 supercrítico e extração com solvente assistida por ultrassom." Universidade Estadual do Oeste do Paraná, 2016. http://tede.unioeste.br/handle/tede/3729.

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Submitted by Marilene Donadel (marilene.donadel@unioeste.br) on 2018-06-04T23:33:22Z No. of bitstreams: 1 Elissandro_Klein_2016.pdf: 4516260 bytes, checksum: 605fbf2e69fd746b1152b1431bf0dca5 (MD5)<br>Made available in DSpace on 2018-06-04T23:33:22Z (GMT). No. of bitstreams: 1 Elissandro_Klein_2016.pdf: 4516260 bytes, checksum: 605fbf2e69fd746b1152b1431bf0dca5 (MD5) Previous issue date: 2016-02-04<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Eugenia pyriformis Cambess. (Uvaia), typical of the Atlantic Forest belongs to the Myrtaceae family, the same family of cher

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22

Heeley, Edward. "Amyas Douglas Connell (1901-1980) : the English modern movement phase of his architectural career." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556170.

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23

Dokarry, Melissa. "β-amyrin synthase : investigating the structure and function of an oxidosqualene cyclase involved in disease resistance in oats". Thesis, University of East Anglia, 2010. https://ueaeprints.uea.ac.uk/20511/.

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24

Servizi, Spencer. "SURVEY OF CNS EXPRESSION OF THE AMYLIN RECEPTOR IN HEALTH AND METABOLIC DISEASE: POTENTIAL RELEVANCE TO ALZHEIMER'S DISEASE." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1564660497165544.

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25

JÃnior, Roberto CÃsar Pereira Lima. "Antinociceptive effect of the mixture of pentacyclic triterpenes alpha- and beta- amyrin in models of visceral nociception in mice." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Protium heptaphyllum March (Burseraceae), a medicinal plant commonly found in the Amazon and in the Northeast regions of Brazil, releases an oil-resin rich in pentacyclic triterpenes, such as the binary mixture of alpha- and beta- amyrin, that manifests antiinflamatory, antinociceptive and gastroprotective properties. This work was aimed to evaluate the antinociceptive effect of the alpha- and beta- amyrin mixture in the cyclophosphamide (400 mg/kg), acetic acid (0,6%, 10mL/kg, i.p.) and mustard oil-induced visceral nociception mod

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26

Wilson, Lois Kathryn. "A probe of the rotenone-piericidin a-amytal binding site of NADH-coenzyme Q reductbase by structure-activity relationships between the new natural benzofuran inhibitor hydroxytremetone and related ben." Thesis, Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/26005.

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27

Sakong, B. M. (Bellonah Motshene). "Isolation and characterization of compounds from Calodendrum capense (Rutaceae) and Lydenburgia cassinoides (Celastraceae) for treatment of fungal and bacterial infections in immunocompromised patients." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/25170.

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Infectious diseases are a serious concern worldwide especially in immune-compromised patients. Some of these diseases are considered to be contagious and are spread via airborne transmission, while others are not contagious, i.e. non-communicable diseases. The problem is compounded by the emergence of pathogens resistant to currently used antimicrobial drugs. A wide range of microbes including bacteria, fungi, parasites, viruses and protozoans are implicated as causative agents of various diseases. Many patients without ready access to Western medical facilities rely on medicinal plants for th

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28

Frota, Julyanne Torres. "Evaluation of hypoglycemic and hypolipidemic activity of mixture of α,β-amyrin, pentacyclic triterpenes isolated of protium heptaphyllum in mice." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=6886.

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nÃo hÃ<br>The Protium heptaphyllum (almecegueira) exudes an amorphous resin consisting of four binary mixtures of triterpenoids, and the mixture of ,-amyrin its major constituent. In folk medicine, the resin of Protium heptaphyllum is used as anti-inflammatory, gastroprotective, analgesic, expectorant and healing. The mixture of pentacyclic triterpenes ,-amyrin (AB) (63:37) has gastroprotective, antipruritic, antiinflammatory and antioxidant properties. Experimental studies with pentacyclic triterpene compounds belonging to the groups ursan, oleanan and lupan sh

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29

Oliveira, Francisco de Assis. "Studies on the pharmacological properties of resin from Protium heptaphyllum (Aubl.) March. and its major constituent, alpha-and beta-amyrin mixture." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=69.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Protium heptaphyllum March (Burseraceae) populary known as âalmÃcegaâ is a popular medicinal plant largely encountered in the Amazon region, various States of Brazil and in several South American Countries. The oily amorphous exudate obtained from this plant is widely used in skin diseases, healing of ulcers, and as an analgesic and anti-inflamatory agent. Phytochemical studies reveled the presence of several monoterpenes and pentacyclic triterpenes such as a mixture of α- e β â amyrin, maniladilol and breine. The present

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30

Miraee-Nedjad, Samaneh. "Early events in the onset of type II diabetes : effects of aggregated amylin (IAPP) on the islet proteome and metabolic pathways." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/early-events-in-the-onset-of-type-ii-diabetes-effects-of-aggregated-amylin-iapp-on-the-isletproteome-and-metabolic-pathways(55b2f0a5-f312-4276-8dfd-d94a0ee04232).html.

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Many diseases are caused by proteins or peptides folding incorrectly and aggregating into fibrils or plaques, including Alzheimer’s disease, Parkinson's disease and type II diabetes. Amyloid formation in the human pancreas occurs via the aggregation of a 37 amino acid peptide called amylin or IAPP which is shown to be toxic to pancreatic β cells. Amylin (IAPP) aggregation initiates a large number of events, leading ultimately to cell death. However the exact cytotoxic action of human IAPP and also the underlying molecular events leading from amylin (IAPP) aggregation to β cell death is still u

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Strid, Carl-Filip. "Mätning av färgutveckling med mobilapplikation som indikator på stressnivå." Thesis, Linköpings universitet, Informationskodning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-118352.

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I saliv förekommer ett enzym, kallat alfa-amylas, som kan ge en fingervisning om en persons upplevda stressnivå. Förekomsten av alfa-amylas kan testas genom att låta droppa ett salivprov på ett särskilt slags filterpapper, som sedan färgas klarblått. Hastigheten på färgningen har visats kunna stå i förhållande till aktiviteten av alfa-amylas, och har tidigare mätts med fotodiod. Det här arbetet har undersökt den tekniska görbarheten i att använda en mobilbaserad lösning istället, detta för att öka tillgängligheten av att kunna utföra dessa mätningar. I arbetet har en lämplig mätmetod först sök

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32

Majebi, Andrew. "The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases." Thesis, University of Wolverhampton, 2014. http://hdl.handle.net/2436/550229.

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Obesity affects about 520 million people world-wide and more recently studies have shown that fat cells produce proteins called adipokines which have various influences on the human metabolism and has helped to change the perspectives of researchers on the concept of the adipose tissue being just a store of energy. As a result of this, adipokines have been reported to represent a connection between obesity and cardiovascular diseases (CVD) and diabetes mellitus. The concentrations and the bases of the effects of the adipokines in beta cell failure of diabetes mellitus and endothelial cell dysf

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33

Wong, Ching-lun Helen. "Twice marginalized: women's identities in a foreign land: an analysis of Jean Rhys's Wide Sargasso Sea and AmyTan's the Joy Luck Club." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31583994.

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34

Salgado, Rinquey David Yetlanezi. "INCREMENTO EN LA ACTIVIDAD ALCOHOLITICA DE AmyA DE Thermotoga maritima MEDIANTE MUTAGÉNESIS." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/68471.

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Las proteínas son las moléculas más complejas que hay, llevando a cabo las funciones necesarias para que cualquier proceso biológico pueda existir. La evolución las ha transformado y refinado para que realicen una función específica cumpliendo con los altos criterios de velocidades y especificidades demandadas por los organismos vivos. Estas características de las proteínas son debido a la participación de muchos factores entre los cuales se encuentran la conformación cuaternaria de la proteína, la carga de aminoácidos que ésta posea, la interacción entre aminoácidos dentro de ésta, así com

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35

Nilsson, Malin. "Naturens rogivande effekt : En studie i hur naturen påverkarstressnivåerna i kroppen vid och efter avslutad fysisk aktivitet." Thesis, Linnéuniversitetet, Institutionen för biologi och miljö (BOM), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-48344.

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Bakgrund. Det är sedan länge känt att naturen har en positiv inverkan på människorshälsa. Flertalet studier genom åren styrker naturens påverkan på människors psykiskahälsa i form av bland annat minskad emotionell upphetsning, medan bevisen för eneventuell förbättrad fysisk hälsa är vaga.Syfte. Undersöka huruvida miljön kan påverka de fysiologiska effekterna vid och efteravslutad fysisk aktivitet avseende sympatikusaktivitet.Metod. En så kallad cross-over studie genomfördes där puls, pH-värde- och alfaamylasaktiviteti saliv samlades in från elva testdeltagare för att mätasympatikusaktivitet. V

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Nyman, Jonas. "Tibetansk jäst : dess amylolytiska aktivitet." Thesis, Högskolan i Borås, Institutionen Ingenjörshögskolan, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-20079.

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Tillverkning av en alkoholhaltig dryck studerades i Indien och prover av dryckenoch tibetansk jäst (phab) togs med till Sverige. Proverna odlades i buljongoch på agarplattor. De förekommande mikroorganismerna isolerades och undersöktes avseende deras amylolytiska aktivitet. Två amylolytiska bakteriearter,B. subtilis och B. cereus, samt två icke amylolytiska jästarter, P. anomalaoch C. lusitaniae isolerades. Tibetansk öl (chang) undersöktes kromatogra skt med avseende på innehåll av alkoholer och yktiga karboxylsyror.Etanolkoncentrationen var 56;5 g=l, ättiksyrakoncentrationen 0;55 g=l och gly

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Meira, Assuero Silva. "Estudo do potencial citotÃxico de novos Ãsteres sintÃticos derivados da mistura triterpenoidica α-/β-amirina em modelos experimentais in vitro." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5497.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>TriterpenÃides sÃo compostos que nos Ãltimos anos tÃm despertados grande interesse em razÃo de sua diversidade estrutural e da descoberta de um amplo espectro de atividades farmacolÃgicas. O presente estudo avaliou o potencial citotÃxico de quatro derivados de uma mistura de α-,β-amirina em linhagens tumorais humanas. Dentre estes, apenas o composto 3-O-Carboximaleinato de α-, β-amirina (3a/3b) foi ativo, especialmente na linhagem leucÃmica HL-60, com valores de IC50 variando entre 1,8 e 3,0 ÂM. Este derivado fo

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38

Oliveira, Cinthya Iamille Frithz BrandÃo de. "Estudo da atividade antinoceptiva de β-amirina, um triterpeno pentaciclÃco isolado de Protium heptaphyllum March. em modelos experimentais de dor." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5158.

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FundaÃÃo de Amparo Ã Pesquisa do Estado do Amazonas<br>Os efeitos dos triterpenos pentaciclicos -amirina e -amirina, isolados a partir da resina de Protium heptaphyllum March. (Burseraceae), foram testados preliminarmente em modelos de nocicepÃÃo oral, sendo que -amirina apresentou significantes efeitos antinociceptivos, norteando a pesquisa com este isolado na investigaÃÃo de seus efeitos em modelos de dor orofacial induzida por capsaicina ou formalina e na dor induzida por capsaicina na cÃrnea de camundongos; na dor tÃrmica (testes de imersÃo de cauda em Ãgua quente e

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Goddard, Jeffrey Harold Ryan 1955. "Patterns of development in nudibranch mollusks from the northeast Pacific Ocean, with regional comparisons." Thesis, Thesis (Ph. D.)--University of Oregon, 1992, 1992. http://hdl.handle.net/1794/9964.

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Typescript. Includes vita and abstract. Bibliography: Includes bibliographical references. Content: Patterns of development in nudibranch mollusks from the northeast Pacific Ocean, with regional comparisons. -- Lecithotrophic development in Doto amyra (Nudibranchia: dendronotacea), with a review of development in the genus. -- Unusually large polar bodies in an aeolid nudibranch, a novel mechanism for producing extra-embryonic yolk reserves. xiv, 237 leaves : ill. ; 29 cm.<br>Biogeographic patterns of developmental mode in marine invertebrates have been examined with respect to latitude,

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Bolarinwa, Olapeju. "Interrogation of Protein Function with Peptidomimetics." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7667.

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Proteins can be described as the “machineries” responsible for almost all tasks in the levels of organizational complexity in multi-cellular organisms namely: the cells, tissues, organs and systems. Any disorder in the function of a protein at any of these levels could result in disease, and a study of protein function is critical to understanding the pathological features of the disease at the molecular level. A quick glance at these abundantly present proteins reveals two striking features: large diversity of biological function, and the variations in structural complexity, which varies from

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Patrick, Sarah A. "Neuroprotective Effects of Pramlintide Against Oxidative Stress and Alzheimer's Disease." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1524145067277978.

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Colas, Debled Elisa. "Etude du repliement des protéines au sein d'une chaperonine." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAV013.

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Les chaperonines sont des machines moléculaires impliquées dans la protection des protéines contre le mauvais repliement et l’agrégation. Ces macromolécules de tailleimportante (environ 1 MDa) sont présentes dans tous les domaines du vivant et sontorganisées en deux anneaux concentriques et empilés l’un sur l’autre, possèdent chacun une cavité en leur centre. Les chaperonines sont particulièrement intéressantes car peu caractérisées par rapport aux autres chaperones, notamment dû à leur grande taille et à leur complexité intrinsèque. Leur mécanisme d’action reste donc assez flou.Ce travail de

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Zanon, Ricardo Basso. "METABÓLITOS SECUNDÁRIOS EM VERNONIA TWEEDIEANA BAKER." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/5948.

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The species Vernonia tweedieana Baker is an herbaceous plant widely distributed in the plains of Paraguai, Argentina and south of Brazil and popularly known as assa-peixe . This plant is used in traditional medicine as an expectorant medicament. So far, this plant was not studied on the phytochemical and biological point of view. This work is a contribution to the phytochemical study of the Asteraceae. The leaves of V. tweedieana Baker were collected in march of 2004, in Ijuí Rio Grande do Sul, Brazil, and identified by Dr. Geraldo C. Coelho (UNIJUÍ). The respective voucher specimen was dep

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Barton, Douglas G. "Microstratigraphic variation in preservational patterns and meristic counts of Amyzon aggregatum, Teleostei, catostomidae, from a 10 000-year interval of the Eocene varved lake deposits of Horsefly, British Columbia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0006/MQ34334.pdf.

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Melo, Caroline MourÃo. "Estudo do efeito farmacolÃgico da alfa, beta-amirina, uma mistura de triterpenos isolada de Protium heptaphyllum, na pancreatite aguda experimental." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=3868.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Os triterpenos pentacÃclicos sÃo compostos naturais com atividade antiinflamatÃria e citoprotetora e sÃo relativamente atÃxicos. A pancreatite aguda, uma inflamaÃÃo aguda do pÃncreas, pode levar Ã sÃndrome da resposta inflamatÃria sistÃmica (SRIS) e Ã sÃndrome da disfunÃÃo mÃltipla de ÃrgÃos (MODS), condiÃÃes que podem levar o paciente ao Ãbito. Neste trabalho, a mistura de triterpenos pentacÃclicos alfa,β-amirina, isolada do Protium hepthaphyllum, foi investigada quanto aos seus efeitos nos modelos de pancreatite aguda indu

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Oliveira, Leonardo Sokolnik de. "Perfil de expressão de genes modulados pela amilina em ilhotas pancreáticas de rato." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-25062009-092443/.

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O Diabetes Mellitus tipo 2 (DM 2) é uma doença crônica na qual os pacientes apresentam capacidade secretória de insulina inadequada para suplantar a resistência insulínica concomitante e, como resultado, advém a hiperglicemia. Os mecanismos que explicam a diminuição da secreção insulínica não são completamente conhecidos e acredita-se que o depósito de amilina, um achado histopatológico freqüente nesses pacientes, esteja envolvido. A amilina humana é uma proteína co-secretada com a insulina capaz de se agregar e se depositar nas ilhotas pancreáticas. Ainda não está totalmente estabelecido se a

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Djemai, Salem. "L'expression de la qualité en berbère : étude morphosémantique et syntaxique de l'adjectif en kabyle." Thesis, Paris, INALCO, 2013. http://www.theses.fr/2013INAL0008.

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Cette thèse est organisée en deux parties. La première partie, qui porte sur la morphosémantique de l’adjectif, est divisée en trois chapitres. Le premier est consacré à l’étude de l’expression de la qualité en berbère. Nous avons commencé, d’abord, ce premier chapitre par un bilan des travaux effectués sur l’adjectif en berbère. Puis, nous avons présenté les différentes procédures de l’expression de la qualité, à part l’adjectif, à savoir les complexes qualifiants, les verbes de qualité et les formes participiales. Dans le deuxième chapitre, nous avons étudié certains aspects morphologiques d

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Andersson, Johanna. "Heterosexuella skådespel i Margareta av Navarras Heptameron." Thesis, Linköpings universitet, Institutionen för kultur och kommunikation, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53949.

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Jag vill i den här uppsatsen beskriva hur sexualitet och genus konstrueras, befästs och utmanas i Margareta av Navarras verk Heptameron. Jag utgår från Judith Butlers och Thomas Laqueurs queerteoretiska perspektiv och visar hur de olika maktdiskurserna kristendom, aristokrati, patriarkalism och nyplatonism påverkar och påtvingar olika konstruktioner av sexualitet och genus, och kan konstatera att alla dessa diskurser bygger på en normerande och normaliserad heterosexualitet som ständigt för tillbaka avvikelserna från denna norm, hos såväl devisanterna som i de två noveller jag studerat, till e

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Karlsson, Ella. "Studies of neuropeptides in pancreatic beta cell function with special emphasis on islet amyloid polypeptide (IAPP)." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-560.

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<p>The presence of protein amyloid in pancreas and its association to diabetes was first described 100 years ago in 1901, but was not identified as Islet Amyloid Polypeptide (IAPP) until 1986. The aim of the present work was to determine the role of the beta cell hormone, IAPP, in normal pancreatic islet physiology and during early disturbances of islet function.</p><p>Intra-islet peptides, i.e. chromogranin peptides and an extra-islet peptide, i.e. leptin, were studied to identify possible endogenous regulators of IAPP and insulin secretion. Chromogranin-B, but not chromogranin-A or pancreast

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Lesma, Jacopo. "β-Hairpin peptidomimetics as inhibitors of hIAPP amyloid protein aggregation : design, synthesis and evaluation Introducing sequential aza-amino acids units induces repeated ß-turns and helical conformations in peptides β-Hairpin peptide mimics decrease human Islet Amyloid Polypeptide (hIAPP) Aggregation". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ018.

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Le diabète de type 2 (DT2), qui compte plus de 400 millions de cas dans le monde, représente 90 % du nombre total de cas de diabète. T2D est une maladie dégénérative associée à la résistance à l’insuline et à la mort des β-cellules pancréatiques liées aux dépôts de la protéine amyloïde hIAPP (également appelée amyline), qui sont observés dans le pancréas de plus de 95 % des patients atteints de DT2. Les traitements actuellement disponibles sont symptomatiques et caractérisés soit par des effets secondaires significatifs, soit par un faible impact sur l’incidence des pathologies associées et la

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