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Journal articles on the topic 'Analgesia; antiemetics'

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1

So, Keum Young, and Sang Hun Kim. "Cutoff Values for Providing the Ideal Intravenous Patient-Controlled Analgesia According to the Intensity of Postoperative Pain—A Retrospective Observational Study." Medicina 57, no. 10 (2021): 1065. http://dx.doi.org/10.3390/medicina57101065.

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Background and Objectives: The cutoff values were analyzed for providing the ideal intravenous patient-controlled analgesia (PCA) that could reduce rescue analgesics or antiemetics requirements, based on the grades of postoperative pain intensity (PPI). Materials and Methods: PCA regimens of 4106 patients were retrospectively analyzed, and they were allocated into three groups with low, moderate, and high PPI grades (groups L, M, and H, respectively) based on numeric rating scores obtained 6 h postoperatively. Opioid and non-opioid analgesic doses were converted into fentanyl-equivalent doses
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2

Abdildin, Yerkin G., Karina Tapinova, Fatima Nabidollayeva, and Dmitriy Viderman. "Epidural dexamethasone for acute postoperative pain management: a systematic review with meta-analysis." Pain Management 13, no. 2 (2023): 129–41. http://dx.doi.org/10.2217/pmt-2022-0065.

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Aim: To study the effect of epidural dexamethasone in postoperative pain management. Methods: Random-effects meta-analysis was conducted in RevMan 5.4. Results: We included nine randomized-controlled trials (RCT) with 657 patients. Dexamethasone demonstrated longer analgesia duration (mean difference 266.18 minutes, 95% CI [3.21,529.14]; p 0.05), lower incidence of nausea and vomiting during the first postoperative day (risk ratio 0.36, 95% CI [0.18,0.71]; p 0.004), and lower antiemetic requirements (risk ratio 0.33, 95% CI [0.14,0.79]; p 0.01). No difference in pain reduction and the length o
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Abdul- Razzaq Mshiemish, Bahir. "Clinical Evaluation of Prochlorperazine Risk / Benefit in Emergency Department Patients Receiving I.V Tramadol." Journal of the Faculty of Medicine Baghdad 53, no. 3 (2011): 320–22. http://dx.doi.org/10.32007/jfacmedbagdad.533839.

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Background: antiemetics are commonly prescribed as prophylactic for nausea and vomiting when opiates analgesics are prescribed in the emergency department.Objective: to assess the incidence of nausea and vomiting after tramadol analgesia, and the effect of prochlorperazine on this incidence.Patients and methods: I.V tramadol was administered with prochlorperzine (group I) or pyridoxine (group II) to 44 patients with acute sever pain.Results: the incidence of nausea and vomiting was not significant between patient groups; while the occurance of extrapyramidal side effects was only seen in the p
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Olmos, Andrea V., Sasha Steen, Christy K. Boscardin, et al. "Increasing the use of multimodal analgesia during adult surgery in a tertiary academic anaesthesia department." BMJ Open Quality 10, no. 3 (2021): e001320. http://dx.doi.org/10.1136/bmjoq-2020-001320.

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ObjectiveMultimodal analgesia pathways have been shown to reduce opioid use and side effects in surgical patients. A quality improvement initiative was implemented to increase the use of multimodal analgesia in adult patients presenting for general anaesthesia at an academic tertiary care centre. The aim of this study was to increase adoption of a perioperative multimodal analgesia protocol across a broad population of surgical patients. The use of multimodal analgesia was tracked as a process metric. Our primary outcome was opioid use normalised to oral morphine equivalents (OME) intraoperati
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Anderson, S. K., and B. A. Al Shaikh. "Diclofenac in Combination with Opiate Infusion after Joint Replacement Surgery." Anaesthesia and Intensive Care 19, no. 4 (1991): 535–38. http://dx.doi.org/10.1177/0310057x9101900408.

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The effect of intramuscular diclofenac or placebo on analgesia obtained and on opiate and antiemetic requirements was observed in a randomised double-blind study of sixty patients receiving continuous intravenous papaveretum. Those patients receiving diclofenac required less papaveretum (P = 0.001) than those receiving placebo. They also had lower visual analogue pain scores (VAS) at four hours (P < 0.05) and decreased requirement for antiemetics (P < 0.02). No gastrointestinal complications were observed in either group and blood loss did not differ significantly between the two.
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Kaur, Randeep, Ruchi Gupta, and Gaganjot Kaur. "Comparison of analgesic efficacy of dexamethasone as an adjuvant to bupivacaine using ultrasound-guided caudal block in children undergoing infraumbilical surgeries." Indian Anaesthetists Forum 26, no. 1 (2025): 4–9. https://doi.org/10.4103/theiaforum.theiaforum_30_23.

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Background and Aims: Regional anesthesia is most effective in obtunding surgical stress and has become a routine intervention in children and infants. Caudal analgesia using local anesthetics is a traditionally used technique, but provides a limited duration of analgesia. Several adjuvants can be added to local anesthetics to increase the duration of action. This study was undertaken to evaluate the analgesic efficacy of dexamethasone added to bupivacaine for caudal block in children. Materials and Methods: This was a prospective, double-blinded study done on 70 children of age group 1–7 years
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7

Radwan, RW, A. Gardner, H. Jayamanne, and BM Stephenson. "Benefits of pre-emptive analgesia by local infiltration at day-case general anaesthetic open inguinal hernioplasty." Annals of The Royal College of Surgeons of England 100, no. 6 (2018): 450–53. http://dx.doi.org/10.1308/rcsann.2018.0059.

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Introduction The open prosthetic repair of inguinal hernias under local anaesthesia (LA) is well established, with the concept of intraoperative ‘pre-emptive analgesia’ evolving so that patients are as comfortable as possible. We used a peri-incisional LA solution in patients undergoing day-case inguinal hernioplasty under general anaesthesia (GA) and recorded use of analgesia in the immediate postoperative period. Methods In this observational cohort study, 100 consecutive unselected men underwent open inguinal hernia repair as a day case. Of these, 75 underwent repair under GA and 25 with pe
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Bailey, Abby M., and Kyle A. Weant. "Dream of the Endless." Advanced Emergency Nursing Journal 46, no. 3 (2024): 195–206. http://dx.doi.org/10.1097/tme.0000000000000528.

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Procedural sedation and analgesia is an essential activity in the emergency department for managing pain and anxiety during a variety of medical procedures. Various pharmacotherapy options, including opioid analgesics, antiemetics, anticholinergics, sedatives, and ketamine have been utilized, all with their unique efficacy and safety profiles. This review highlights the challenges associated with using certain agents and discusses emerging trends such as the use of newer synthetic opioids and the expanding use of dexmedetomidine. Overall, the selection of the optimal agents for procedural seda
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Joshi, Girish P., Larry Duffy, Jamal Chehade, Jay Wesevich, Noor Gajraj, and Edward R. Johnson. "Effects of Prophylactic Nalmefene on the Incidence of Morphine-related Side Effects in Patients Receiving Intravenous Patient-controlled Analgesia." Anesthesiology 90, no. 4 (1999): 1007–11. http://dx.doi.org/10.1097/00000542-199904000-00013.

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Background Opioid-related side effects associated with intravenous patient-controlled analgesia can be reduced by a low-dose naloxone infusion. The influence of nalmefene, a pure opioid antagonist with a longer duration of action, on opioid-related side effects has not been evaluated. This study was designed to determine the dose-response relation for nalmefene for the prevention of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. Methods One hundred twenty women undergoing lower abdominal surgery were enrolled in the study. General anesthesia was i
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Zanvettor, Alex, Wolfgang Lederer, Bernhard Glodny, Andreas P. Chemelli, and Franz J. Wiedermann. "Procedural sedation and analgesia for percutaneous trans-hepatic biliary drainage: Randomized clinical trial for comparison of two different concepts." Open Medicine 15, no. 1 (2020): 815–21. http://dx.doi.org/10.1515/med-2020-0220.

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AbstractProcedural sedation and analgesia (PSA) is important during painful dilatation and stenting in patients undergoing percutaneous trans-hepatic biliary drainage (PTBD). A prospective, nonblinded randomized clinical trial was performed comparing different analgesic regimens with regard to the patient’s comfort. Patients were randomly assigned to two treatment groups in a parallel study, receiving either remifentanil or combined midazolam, piritramide, and S-ketamine. The primary study endpoint was pain intensity before, during, and after the intervention using the numerical rating scale (
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11

Kozyrev, Alexander S., Anna V. Zaletina, Kirill A. Kartavenko, Angelina S. Strelnikova, and Maria S. Pavlova. "Comparative evaluation of options for postoperative analgesia during surgical correction of congenital spine deformity in children." Pediatric Traumatology, Orthopaedics and Reconstructive Surgery 7, no. 3 (2019): 63–70. http://dx.doi.org/10.17816/ptors7363-70.

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Background. In the planning of anesthesia and postoperative therapy for surgical correction of congenital spinal deformity, the volume, the spine that is operated, and the patients age are all factors to consider. In pediatric practice, the use of opioid analgesics for pain relief in the postoperative period after extensive and traumatic surgical interventions is generally accepted. There is very little information on the effectiveness and safety of prolonged epidural analgesia in young children in spinal surgery.
 Aim. The aim of this study was to give a comparative assessment of the use
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12

Kojima, Yuki, and Yuichi Tamatsu. "An Appropriate Setting for a Patient-Controlled Analgesia Pump for Continuous Local Anesthesia After Bimaxillary Osteotomy." Anesthesia Progress 72, no. 2 (2025): 114–18. https://doi.org/10.2344/24-0021.

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In this report, we aimed to describe an appropriate setting for a patient-controlled analgesia (PCA) pump for postoperative pain control using local anesthetic after bimaxillary osteotomy, which is considered a highly invasive procedure. We conducted a cadaver study to determine the appropriate flow rate setting and then applied our findings to a clinical case. We examined the distribution of local anesthetic administered as ultrasound-guided inferior alveolar nerve blocks (UGIANBs) at different volumes. Using the same UGIANB approach, we placed an indwelling catheter in a healthy male who had
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Kim, Min Kyoung, Hyun Kang, Geun Joo Choi, et al. "Effect of Palonosetron, Dexamethasone, or Palonosetron and Dexamethasone in Postoperative Nausea and Vomiting in Highly Susceptible Thyroidectomy Patients: A Randomized Trial." International Surgery 101, no. 3-4 (2016): 106–15. http://dx.doi.org/10.9738/intsurg-d-15-00147.1.

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Our study aimed to compare the efficacy of dexamethasone added to palonosetron to both palonosetron and dexamethasone monotherapy for preventing postoperative nausea and vomiting in highly susceptible patients receiving opioid-based, intravenous patient-controlled analgesia after thyroidectomy. Nonsmoking women who underwent total thyroidectomy were randomly allocated to either the dexamethasone group (Group D), the palonosetron group (Group P), or to the dexamethasone plus palonosetron group (Group DP). The severity of nausea and pain, the number of episodes of vomiting, the administrations o
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14

Tramer, Martin R., and Bernhard Walder. "Efficacy and Adverse Effects of Prophylactic Antiemetics During Patient-Controlled Analgesia Therapy." Anesthesia & Analgesia 88, no. 6 (1999): 1354–61. http://dx.doi.org/10.1213/00000539-199906000-00030.

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15

Tramer, Martin R., and Bernhard Walder. "Efficacy and Adverse Effects of Prophylactic Antiemetics During Patient-Controlled Analgesia Therapy." Anesthesia & Analgesia 88, no. 6 (1999): 1354–61. http://dx.doi.org/10.1097/00000539-199906000-00030.

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Fukuda, Taeko, Shinobu Imai, Shunji Simoda, Masaya Nakdera, and Hiromasa Horiguchi. "Comparison of peripheral nerve block with local infiltration analgesia regarding walking ability after total knee replacement: A retrospective, propensity-score matched-pair cohort study." Journal of Orthopaedic Surgery 28, no. 2 (2020): 230949902093165. http://dx.doi.org/10.1177/2309499020931656.

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Purpose: It is unclear whether perioperative analgesic techniques affect the functional outcome of total knee replacement (TKR). We investigated the effects of peripheral nerve block (PNB) and local infiltration (LI) on walking ability after TKR. Methods: The medical records of 7143 patients who underwent TKR using general anesthesia with PNB or LI techniques were reviewed. Factors affecting independence and/or improvement of walking after surgery were investigated using multivariate regression analysis. To adjust for baseline differences and minimize selection bias for the chosen analgesic te
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Ng, Shin Ann, Praveena Seevaunnamtum, Mohamad Hasyizan Hassan, Mohd Zulfakar Mazlan, and Sanihah Che Omar. "Efficacy of Prophylactic Dexamethasone on Postoperative Nausea and Vomiting in Laparoscopic Appendicectomy: A Randomized Controlled Trial." Journal of Clinical and Health Sciences 10, no. 1 (2025): 49–57. https://doi.org/10.24191/jchs.v10i1.5427.

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Background: Dexamethasone has been established as an effective prophylactic antiemetic in various studies done in elective surgery. However, its efficacy in emergency surgery specifically, laparoscopic appendicectomy is not well documented. This study was conducted to compare the efficacy of prophylactic intravenous (IV) dexamethasone 8mg in preventing postoperative nausea and vomiting (PONV) in this surgical population. Methods: A total of 84 participants were recruited for the study in Hospital Universiti Sains Malaysia and were randomly assigned in equal numbers to treatment group with prop
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Satıcı, Muhammed Halit, Mahmut Sami Tutar, Yasin Tire, et al. "Effect of suprainguinal fascia iliaca block on recovery quality after total knee arthroplasty: a multicenter, prospective, randomized controlled, double-blind study." Journal of Health Sciences and Medicine 8, no. 1 (2025): 103–8. https://doi.org/10.32322/jhsm.1595732.

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Aims: Total knee arthroplasty is a common procedure for patients with advanced gonarthrosis, often leading to significant postoperative pain. Effective pain management, including multimodal analgesia with peripheral nerve blocks, is essential. The suprainguinal fascia iliaca block is a technique that targets key nerves responsible for knee sensation and is similar in effect to the lumbar plexus block. This research aims to evaluate whether suprainguinal fascia iliaca block improves the Quality of Recovery-15 scores in Total knee arthroplasty patients. Methods: A randomized, prospective, contro
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Chand, Trilok, Amrita Gupta, Avanish Kumar Saxena, Pulkit Agarwal, and Shanu Maheshwari. "Transversus Abdominis Plane Block Vs. Paravertebral Block for Post-Operative Analgesia Following Inguinal Herniorrhaphy - A Cross-Sectional North Indian Sub-Population Study." Journal of Evidence Based Medicine and Healthcare 8, no. 31 (2021): 2880–84. http://dx.doi.org/10.18410/jebmh/2021/526.

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BACKGROUND Inguinal hernia is a frequently encountered surgical problem. General anaesthesia carries the risk of possible airway complications. Regional blocks improve acute post-operative pain, decrease post-operative visual analogue scale (VAS) score and patient can mobilise early. The purpose of this study was to compare the effectiveness of transversus abdominis plane (TAP) block vs. paravertebral (PVB) block for post-operative analgeia in inguinal hernia surgeries. METHODS We conducted a research on 64 patients of age > 18 years with American society of Anaesthesiologists (ASA I – III)
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Arellano, Ramiro J., Meena L. Pole, Sara E. Rafuse, et al. "Omission of Nitrous Oxide from a Propofol-based Anesthetic Does Not Affect the Recovery of Women Undergoing Outpatient Gynecologic Surgery." Anesthesiology 93, no. 2 (2000): 332–39. http://dx.doi.org/10.1097/00000542-200008000-00009.

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Background Although nitrous oxide (N2O) is used commonly during anesthesia, clinically relevant advantages-disadvantages of using this agent are not well established in the ambulatory setting. This study in women undergoing ambulatory gynecologic surgery compares outcomes in patients administered total intravenous anesthesia with propofol versus the propofol plus N2O. The primary outcome was the time to home readiness. Secondary outcomes included the incidence of postanesthetic adverse events. Methods Women presenting for elective ambulatory termination of pregnancy or gynecologic laparoscopy
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Hirata, Ikkou, Masahiro Iwamoto, Hiroki` Matsui, Hiromi Yoshinuma, and Ryohkan Funakoshi. "Droperidol Reduces Postoperative Nausea and Vomiting and Supports the Continuation of Intravenous Patient-Controlled Analgesia with Fentanyl." Journal of Pharmacy & Pharmaceutical Sciences 23 (June 22, 2020): 220–30. http://dx.doi.org/10.18433/jpps30902.

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PURPOSE: To examine the impact of adding droperidol to fentanyl-based intravenous patient-controlled analgesia (IVPCA) on the discontinuation of IVPCA use due to postoperative nausea and vomiting (PONV). METHODS: Patients who underwent surgeries other than abdominal surgeries and used IVPCA between April 2014 and March 2018 were selected. Patients using IVPCA with fentanyl alone were compared to patients using droperidol added to IVPCA. Patients were allocated to one of two groups depending on the drug used for IVPCA: 1) control group, fentanyl alone; 2) droperidol group, droperidol with fenta
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McCarthy, Robert J., Katarina G. Ivankovich, Emily A. Ramirez, et al. "Association of the addition of a transversus abdominis plane block to an enhanced recovery program with opioid consumption, postoperative antiemetic use, and discharge time in patients undergoing laparoscopic bariatric surgery: a retrospective study." Regional Anesthesia & Pain Medicine 45, no. 3 (2020): 180–86. http://dx.doi.org/10.1136/rapm-2019-101009.

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BackgroundIncreasing numbers of laparoscopic bariatric surgeries are being performed and enhanced recovery from anesthesia and surgery (ERAS) protocols have been implemented to optimize care for these patients. We evaluated the effects of an anesthesiologist placed preoperative transversus abdominis plane block (TAP) as part of a bariatric surgery ERAS protocol. We hypothesized that an anesthesiologist placed preoperative TAP added to an ERAS protocol following laparoscopic bariatric surgery would reduce total opioid consumption.MethodsA retrospective cohort of consecutive patients between Jan
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Oleshchenko, I. G., D. V. Zabolotskii, T. N. Iureva, V. A. Zaika, and V. A. Koriachkin. "Postoperative anesthesia for vitreoretinal surgery in children." Regional Anesthesia and Acute Pain Management 14, no. 3 (2021): 156–63. http://dx.doi.org/10.17816/1993-6508-2020-14-3-156-163.

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Vitreoretinal surgery for retinal detachments in children is an effective, sometimes the only method to restore vision. As practice shows, the use of minimally invasive regional techniques is increasingly used for combined anesthesia in ophthalmic surgery in children. In the postoperative period, the use of blockades can provide prolonged analgesia, thereby improving the childs comfort level after the surgery. All types of blockades in ophthalmology have certain risks, but the pterygopalatine blockade has not any, since it is performed outside the eye structures. The research of the use of the
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International, Journal of Medical Science and Innovative Research (IJMSIR). "GA-Related Risk Factors for Postoperative Nausea and Vomiting: Meta-Analysis Review." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 5 (2024): 27–33. https://doi.org/10.5281/zenodo.15435312.

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<strong>Abstract</strong> <strong>Introduction: </strong>Postoperative nausea and vomiting (PONV) are common side effects that must be addressed effectively after general anaesthesia to ensure a patient's full recovery. This review will highlight the significant risk factors associated with PONV and provide the most effective strategies for reducing its incidence. <strong>Methods</strong>: This study is based upon the collected data from various articles published in PubMed, Medline, and Scholars, which helped us draw conclusions and make recommendations. <strong>Results</strong><strong>: </st
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Skledar, Susan J., Brian A. Williams, Manuel C. Vallejo, et al. "Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is “Zero Tolerance“ Achievable?" Scientific World JOURNAL 7 (2007): 959–77. http://dx.doi.org/10.1100/tsw.2007.131.

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For ondansetron, dexamethasone, and droperidol (when used for prophylaxis), each is estimated to reduce risk of postoperative nausea and/or vomiting (PONV) by approximately 25%. Current consensus guidelines denote that patients with 0–1 risk factors still have a 10–20% risk of encountering PONV, but do not yet advocate routine prophylaxis for all patients with 10–20% risk. In ambulatory surgery, however, multimodal prophylaxis has gained favor, and our previously published experience with routine prophylaxis has yielded PONV rates below 10%. We now propose a “zero-tolerance” antiemetic algorit
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Bignell, Mark, Anna Bayston, David Nunn, and Michael P. Lewis. "Mo1458 The Influence of Analgesia, Antiemetics and Operative Factors on Admission Following Cholecystectomy: A Retrospective Review." Gastroenterology 142, no. 5 (2012): S—1069—S—1070. http://dx.doi.org/10.1016/s0016-5085(12)64152-3.

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Mathew, Abbey, Anish Mathew Thomas, and Anand S. "A comparative clinical study of ramosetron and ramosetron with dexamethasone for the prevention of postoperative nausea and vomiting in laparoscopic surgeries." Indian Journal of Clinical Anaesthesia 9, no. 1 (2022): 75–80. http://dx.doi.org/10.18231/j.ijca.2022.016.

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Postoperative nausea and vomiting (PONV) along with pain and shivering are frequently observed in patients recovering from surgery and general anesthesia. To compare the efficacy of Ramosetron alone and in Combination with Dexamethasone in patients undergoing laparoscopic surgeries, with respect to nausea, vomiting , requirement of rescue analgesia and antiemetics, discharge time, and also side effects.Current study was a prospective observational double-blind study conducted at a tertiary care hospital. A total of 60 ASA grade I and II patients of age group 20-50 years undergoing elective lap
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Kelleci, Yavuz, Ruslan Abdullayev, Beliz Bilgili, Ayten Saraçoğlu, and Tümay Umuroğlu. "Epidural versus intravenous analgesia for pain control in kidney donors, a retrospective cohort study. Is there a kinship relationship?" Eurasian Journal of Anesthesiology and Intensive Care 1, no. 1 (2024): 1–5. http://dx.doi.org/10.51271/eajaic-0001.

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Aims: Best care must be provided for live kidney donors, including postoperative pain control. Treatment options include iv intermittent analgesics, iv or epidural patient-controlled analgesia (PCA). In this study we aimed to compare these modalities with respect to their analgesic efficacy. Methods: A retrospective analysis of fifty-eight live donor nephrectomy patients operated in a 7-year-period in a university hospital performed. Investigational Review Board approval has been obtained. Data of the patients’ postoperative analgesia methods, degree of kinship with the recipient, postoperativ
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Kim, Seung Hyun, Hyang Mi Ju, Chong-Hyuck Choi, Hae Ri Park, and Seokyung Shin. "Inhalational versus intravenous maintenance of anesthesia for quality of recovery in patients undergoing corrective lower limb osteotomy: A randomized controlled trial." PLOS ONE 16, no. 2 (2021): e0247089. http://dx.doi.org/10.1371/journal.pone.0247089.

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Background Inhalational anesthesia and propofol-based total intravenous anesthesia (TIVA) are the two most popular methods of general anesthesia with distinct characteristics that may affect quality of recovery (QOR) differently. This study compared QOR after corrective lower limb osteotomy between desflurane-based inhalational anesthesia and propofol-based TIVA. Methods Sixty-eight patients, ASA class I or II who underwent corrective lower limb osteotomy were randomized to receive either desflurane anesthesia or propofol TIVA. The primary outcome was quality of recovery 40 (QoR-40) questionna
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Hartmann, R. J., E. Lang, T. Rich, et al. "MP011: Using GRADE-based recommendations for analgesia and antiemetics in electronic order sets to influence physician behaviour towards best practice and cost-savings." CJEM 18, S1 (2016): S69—S70. http://dx.doi.org/10.1017/cem.2016.152.

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Introduction: The addition of computerized physician order entry (CPOE) to Emergency Departments in recent years has led to speculation over potential benefits and pitfalls. Recent studies have shown benefits to CPOE, though there lacks sufficient evidence on how it could change physician behaviour. Physician practices are known to be difficult to change, with getting evidence into daily practice being the main challenge of knowledge translation. Our study aims were to determine if well-designed electronic order sets for CPOE improved MD practices. Methods: The Calgary Zone Pain Management in
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Grauman, Sven, Jakob Boethius, and Joakim Johansson. "Regional Anaesthesia Is Associated with Shorter Postanaesthetic Care and Less Pain Than General Anaesthesia after Upper Extremity Surgery." Anesthesiology Research and Practice 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/6308371.

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Introduction. For surgery on the upper extremity, the anaesthetist often has a choice between regional anaesthesia (RA) and general anaesthesia (GA). We sought to investigate the possible differences between RA and GA after upper extremity surgery with regard to postoperative patient comfort. Methods. This is a retrospective observational study that was performed at an acute care secondary referral centre. One hundred and eighty-seven procedures involving orthopaedic surgery on the upper extremity were included. The different groups (RA and GA) were compared regarding the primary outcome varia
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Zeng, Min, Maoyao Zheng, Jie Wang, Shu Li, Nan Ji, and Yuming Peng. "Effect of perioperative dexmedetomidine on postoperative delirium in patients with brain tumours: a protocol of a randomised controlled trial." BMJ Open 14, no. 11 (2024): e084380. http://dx.doi.org/10.1136/bmjopen-2024-084380.

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IntroductionNeurosurgery is a risk factor for postoperative delirium. Dexmedetomidine has a potential effect on reducing postoperative delirium. We aim to test the primary hypothesis that perioperative administration of dexmedetomidine reduces the incidence of postoperative delirium in patients undergoing neurosurgical resections of temporal glioma.MethodsThis is a single-centre, randomised, blinded and parallel-group controlled trial. A total of 366 patients will be randomised to either dexmedetomidine group (n=183) or placebo group (n=183). Subjects assigned to dexmedetomidine group will be
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Ruan, Qing, Shawn Diamond, Scott Zimmer, and Matthew Iorio. "Assessing the Safety and Efficacy of Regional Anesthesia for Lower Extremity Microvascular Reconstruction: Enhancing Recovery." Journal of Reconstructive Microsurgery 34, no. 04 (2018): 293–99. http://dx.doi.org/10.1055/s-0037-1621726.

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Background Perioperative pain, increased sympathetic tone, and peripheral vasospasm may be safely managed with regional nerve blockade during microvascular reconstruction in the lower extremity. Limited reports exist in this setting; therefore, we evaluated our use of peripheral nerve catheters (PNCs) during microvascular limb salvage to determine safety and efficacy for both patient and flap. Methods A single-institution, retrospective review of a prospectively maintained database on all patients with lower extremity free tissue transfers between 2012 and 2017 was completed. Patients were mat
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Kang, Jun-Hyeok, Yumi Seo, Hyunji Lee, Woo Young Kim, and E. Sun Paik. "Can a Continuous Wound Infiltration System Replace Intravenous Patient-Controlled Analgesia for Postoperative Pain Management after a Single-Port Access Laparoscopy?" Journal of Clinical Medicine 13, no. 19 (2024): 5718. http://dx.doi.org/10.3390/jcm13195718.

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Background: The aim of this study was to determine whether continuous wound infiltration (CWI) can replace intravenous patient-controlled analgesia (IV PCA) and to investigate effective pain control strategies after a single-port access (SPA) laparoscopy for adnexal disease. Methods: A total of 470 patients (the CWI group [n = 109], the IV PCA group [n = 198], and the combined group [n = 163]) who underwent an SPA adnexal laparoscopy and who received CWI or IV PCA for postoperative pain management were retrospectively reviewed. The numeric rating scale (NRS) pain score at 6, 12, 24, and 48 h (
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B, Nirmala Devi, Surisetty Sreenivasa Rao, and Raju Bhukya. "A Prospective Study to Compare the Effects of General Anaesthesia and Regional Anaesthesia among Patients Posted for Laparoscopic Appendicectomy, in SV Medical College, Tirupati, Andhra Pradesh." Journal of Evidence Based Medicine and Healthcare 8, no. 26 (2021): 2333–38. http://dx.doi.org/10.18410/jebmh/2021/435.

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BACKGROUND We wanted to compare the effects of general anaesthesia and regional anaesthesia in cases posted for laparoscopic appendicectomy and also compare various parameters like hemodynamic changes, postoperative analgesia, and postoperative complications in both the techniques. METHODS After obtaining permission from scientific and ethical committee of SVMC, Tirupati, we conducted the study on 60 patients attending SV Medical College, Tirupati from September 2018 to August 2019, who were in ASA GRADE 1 &amp; 2, and posted for laparoscopic appendicectomy. We divided them into two groups Gro
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Pfaffenrath, V., and S. Scherzer. "Analgesics and NSAIDs in the treatment of the acute migraine attack." Cephalalgia 15, no. 15_suppl (1995): 14–20. http://dx.doi.org/10.1111/j.1468-2982.1995.tb00043.x.

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In the treatment of migraine attacks, an antiemetic in combination with an analgesic or ergot alkaloid is widely recommended. Medication should be introduced as early as possible, but only when there is no doubt that the headache is due to migraine. The antiemetic provides relief from the nausea and vomiting and also enhances the resorption of analgesics or ergot preparations. Domperidone 20 mg orally and 20 mg metoclopramide as suppository or 10–20 mg orally are mostly used as antiemetics. Analgesics such as 1000 mg acetylsalicylic acid as effervescent tablets, or 1000 mg paracetamol as effer
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Leppert, Wojciech, and Krzysztof Nosek. "Comparison of the Quality of Life of Cancer Patients with Pain Treated with Oral Controlled-Release Morphine and Oxycodone and Transdermal Buprenorphine and Fentanyl." Current Pharmaceutical Design 25, no. 30 (2019): 3216–24. http://dx.doi.org/10.2174/1381612825666190717091230.

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Aim: To compare the effects of oral morphine and oxycodone and transdermal fentanyl and buprenorphine on quality of life (QoL) of cancer patients with severe pain. Patients and Methods: Cancer patients with severe pain (NRS 6-10) treated at home and in outpatient clinics who failed to respond to non-opioids and/or “weak” opioids were randomized to morphine, oxycodone, fentanyl, or buprenorphine treatment for 28 days. Immediate-release oral morphine was rescued analgesic and 10-ml lactulose twice daily was prophylaxis of constipation; no antiemetics were used for prophylaxis. Results: Above all
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Mary Boban, Sheena, Jimmy Joseph, Sanjana Vishwanathan, and Jishnu Narayanan Nair. "EFFECT OF PREINDUCTION DEXAMETHASONE 8 MG VS 16 MG FOR RELIEF OF POSTOPERATIVE PAIN AND NAUSEA AND VOMITING IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANAESTHESIA." International Journal of Advanced Research 13, no. 04 (2025): 559–65. https://doi.org/10.21474/ijar01/20753.

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Aims and Objectives: This study aimed to evaluate and compare the impact of administering 8 mg versus 16 mg of dexamethasone intravenously prior to induction of general anesthesia on postoperative pain, nausea, and vomiting (PONV). Outcomes assessed included visual analogue scale (VAS) scores for pain, occurrence of PONV, and the need for additional analgesics or antiemetics postoperatively. Methodology: A randomized prospective study was planned where 68 patients aged 18 to 65, who were in excellent health (ASAI and II) and needed elective surgeries with general anesthesia and endotracheal in
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Seyedsadeghi, Mirsalim, Amirahmad Arabzadeh, Masood Entezariasl, Bita Shahbazzadegan, Sajjad Dindar, and Khatereh Isazadehfar. "The Effect of Nicotine Patch on Reducing Nausea, Vomiting, and Pain Following Laparoscopic Cholecystectomy: A Randomized Clinical Trial." Addiction and Health 15, no. 1 (2023): 39–44. http://dx.doi.org/10.34172/ahj.2023.1364.

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Background: The effect of nicotine on nausea, vomiting, and postoperative pain has been investigated in studies on animals and humans. This study aimed to evaluate the effect of nicotine patch on decreasing nausea, vomiting, and pain in laparoscopic cholecystectomy. Methods: The study sample consisted of 100 non-smoking patients undergoing laparoscopic cholecystectomy under general anesthesia in a triple-blind clinical trial. One hour after the start of surgery, patients were randomly assigned to receive 17.5-mg nicotine or placebo patches. The patches located on the right arm were left for 24
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Kang, Chan, Gi Soo Lee, Dong Yeol Kim, et al. "Can Combination of Peripheral Nerve Block and Non-opioidal Patient Controlled Analgesia Be an Effective Postoperative Pain Control Method?" Foot & Ankle Orthopaedics 4, no. 4 (2019): 2473011419S0023. http://dx.doi.org/10.1177/2473011419s00239.

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Category: Ankle, Pain medicine Introduction/Purpose: Even though bone surgery is very painful after operation, there is no established method to control postoperative pain due to efficacy and side effects. Ultrasound-guided peripheral nerve block (PNB) and nonsteroidal anti- inflammatory drugs (NSAIDs) patient controlled analgesia (PCA) can effectively control pain and reduce side effects. Methods: We conducted a prospective study of 150 patients over 18 years of age who underwent bone surgery from June 2018 to December 2018. All operations were performed under anesthetic ultrasound-guided PNB
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Athanasios, Petrou, Papalambros Alexandros, Brennan Nicholas, et al. "Pleomorphic Giant Cell Carcinoma of the Pancreas with Hepatic Metastases—Initially Presenting as a Benign Serous Cystadenoma: A Case Report and Review of the Literature." HPB Surgery 2010 (December 20, 2010): 1–5. http://dx.doi.org/10.1155/2010/627360.

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Introduction. Pleomorphic giant cell pancreatic cancer is a very rare and aggressive pancreatic neoplasm. A case of pleomorphic giant cell pancreatic cancer presenting as a cystic lesion and in association with a serous cystadenoma presents a unique case which has not been described before. Case Presentation. A 44-year-old alcoholic man presented with abdominal pain, vomiting, and weight loss. Initially, imaging suspected a pancreatic pseudocyst measuring 4.2 cm. Endoscopic ultrasound- (EUS-) guided fine-needle aspiration revealed a serous cystadenoma. With conservative intervention only (flui
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Cubeddu, Francesca, Gerolamo Masala, Giovanni Sotgiu, Alessandra Mollica, Sylvia Versace, and Giovanni Mario Careddu. "Cardiorespiratory Effects and Desflurane Requirement in Dogs Undergoing Ovariectomy after Administration Maropitant or Methadone." Animals 13, no. 14 (2023): 2388. http://dx.doi.org/10.3390/ani13142388.

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General anesthesia for ovariectomy in dogs is based on a balanced anesthesia protocol such as using analgesics along with an inhalant agent. While opioids such as fentanyl and methadone are commonly used for their analgesic potency, other drugs can also have analgesic effects. Maropitant, an antiemetic for dogs and cats, has also been shown to exert analgesic effects, especially on visceral pain. The aim of this study was to compare the cardiorespiratory effects and analgesic properties of maropitant and methadone combined with desflurane in dogs undergoing ovariectomy. Two groups of 20 health
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Mahajan, Shweta, Nagesh Pandit, Sandeep Kashyap, and Sonali Kaushal. "A Randomised Control Trial of Pericapsular Nerve Group (PENG) Block Analgesia in Pelvic or Acetabulum Fractures." Anesthesia & Clinical Research 15, no. 4 (2024): 5. https://doi.org/10.35248/ 2155-6148.24.15.1149.

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Background and Aim: Pain management is a key factor in the prehospital and perioperative periods of patients with hip and pelvic fractures. It has been known that the coverage of articular nerves around hip joints is critical for effective analgesia and the spread of conventional analgesics doesn&rsquo;t cover the obturator nerve therefore, may not cause effective analgesia. Since, block covers most of the hip joint articular nerves, this technique provides better analgesia as compared to conventional analgesics. Methods: Forty ASA I/II/III patients belonging to age groups 18-75 years with rad
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Ang, R. J., B. Haye, S. Noden, and B. Y. Al-Saffar. "85 Improving Rates of Medication Prescription on Admission by the Clerking Doctor in Patients with Neck of Femur Fractures." Age and Ageing 50, Supplement_1 (2021): i12—i42. http://dx.doi.org/10.1093/ageing/afab030.46.

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Abstract Introduction Ensuring correct medications are prescribed for all patients admitted with neck of femur fractures is essential for presurgical optimisation, analgesia and perioperative care. This quality improvement project examines patients over the age of 65 who were managed following the orthogeriatric pathway for all neck of femur fractures at Queen Elizabeth Hospital, Woolwich. Guidelines exist that include a list of medications that should be prescribed for all of such patients on admission, including VTE prophylaxis, analgesia, antiemetics, laxatives, IV fluids and preload. The a
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Denney, Jeff M., Karen L. Blackburn, Courtney C. Bleach, et al. "THE EFFECTS OF MUSIC INTERVENTION ON WOMEN’S ANXIETY BEFORE AND AFTER CESAREAN DELIVERY: A Randomized Controlled Trial." Music and Medicine 10, no. 4 (2018): 225. http://dx.doi.org/10.47513/mmd.v10i4.622.

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ABSTRACT:Objective: To assess effect of perioperative music intervention on maternal anxiety levels, physiologic metrics, and medication use for anxiety, nausea and pain during and after scheduled cesarean section. Methods: Women assigned to music intervention group were compared against controls. Physiologic metrics, medication requirements, and STAI scores were assessed for all participants. Results: 50 women were enrolled, assigned to either music intervention (n=25) or control (n=25) and analyzed. Physiologic metrics were similar between groups. Antiemetic, anxiolytic, and analgesic medica
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El Sayed, Mazen, Hani Tamim, and N. Clay Mann. "Description of Medication Administration by Emergency Medical Services during Mass-casualty Incidents in the United States." Prehospital and Disaster Medicine 31, no. 2 (2016): 141–49. http://dx.doi.org/10.1017/s1049023x1600008x.

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AbstractBackgroundEmergency Medical Services (EMS) preparedness and availability of essential medications are important to reduce morbidity and mortality from mass-casualty incidents (MCIs).ObjectivesThis study describes prehospital medication administration during MCIs by different EMS service levels.MethodsThe US National EMS Public-Release Research Dataset maintained by the National Emergency Medical Services Information System (NEMSIS) was used to carry out the study. Emergency Medical Services activations coded as MCI at dispatch, or by EMS personnel, were included. The Center for Medicar
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Vincent, Divya, Aaron Dsouza, Hezil Saldanha, Antony Eapen, and Kishan Shetty. "Post Operative Analgesic Efficacy Of Erector Spinae Plane Block VS Serratus Anterior Plane Block In Patients Undergoing Modified Radical Mastectomy." Sri Lankan Journal of Anaesthesiology 33, no. 02 (2025): 169–77. https://doi.org/10.4038/slja.v33i02.9569.

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Introduction: Postoperative pain relief following modified radical mastectomy is usually achieved with a combination of systemic opioids and non-opioid simple analgesics. Variable efficacy of pain relief and opioid associated side effects are major limitations with significant impact on the quality of postoperative recovery.Objectives: To compare the analgesic efficacy of ultrasound-guided Erector Spinae Plane Block (ESPB) versus Serratus Anterior Plane Block (SAPB) in patients undergoing Modified Radical Mastectomy (MRM) in terms of the efficacy and duration of analgesia and intraoperative an
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Tang, Jun, Shitong Li, Paul F. White, et al. "Effect of Parecoxib, A Novel Intravenous Cyclooxygenase Type-2 Inhibitor, on the Postoperative Opioid Requirement and Quality of Pain Control." Anesthesiology 96, no. 6 (2002): 1305–9. http://dx.doi.org/10.1097/00000542-200206000-00007.

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Background The analgesic efficacy and side effect profile of intravenous parecoxib, a novel cyclooxygenase type-2 (COX-2) inhibitor, was assessed in a double-blinded, placebo-controlled study involving patients undergoing major gynecologic surgical procedures. Methods After Institutional Review Board approval, 60 consenting women, American Society of Anesthesiologists (ASA) physical status I-III, undergoing lower abdominal surgery with a standardized general anesthetic technique were randomly assigned to receive one of three study medications: group 1 (control) received normal saline; group 2
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Endang Susilowati and Dini Mei Arisa. "Prescribing Profile among Pregnancy in the Outpatient Pharmacy Installation of Bokor Hospital, Malang." Journal Pharmasci (Journal of Pharmacy and Science) 7, no. 2 (2022): 117–23. http://dx.doi.org/10.53342/pharmasci.v7i2.291.

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Drug therapy in pregnant women is important because it can cross the placental blood barrier so that it has a negative effect on fetal development. This study aims to determine the profile of drug prescription in pregnant women including drug therapy class, drug name, drug category based on fetal safety. This study aims to determine the profile of drug prescribing in pregnant women including drug therapy class, type of drug and drug category based on safety for the fetus. The study used retrospective data in the form of 100 prescription sheets at the Outpatient Pharmacy Installation of Bokor H
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Abd-Elshafy, Dr Sayed Kaoud. "A New Look on Adding Dexamethasone as an Adjuvant to Caudal Bupivacaine; Efficacy on Postoperative Pain and Vomiting in Pediatric Patients." July 2016 6;19, no. 6;7 (2016): E841—E852. http://dx.doi.org/10.36076/ppj/2016.19.e841.

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Background: Controlling postoperative pain and vomiting in children remains a great challenge. Objective: Study the efficacy of adding dexamethasone to caudal bupivacaine on postoperative analgesia and vomiting. Study Design: Prospective, randomized double blind controlled clinical trial. Setting: Assiut University Hospital. Patients: Ninety children ASA I-II, undergoing lower orthopedic surgeries. Methods: Patients were randomly allocated into 3 equal groups. All received caudal block after induction of anesthesia with 0.5 mL/kg of 0.25% bupivacaine in addition to 5 mL intravenous (IV) normal
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