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Journal articles on the topic 'Analgesic Pain Stick'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Nagalakshmi.R*, Surinder Kaur. "FORMULATION AND EVALUATION OF MEDICATED ANALGESIC STICKS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 471–77. https://doi.org/10.5281/zenodo.1036422.

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The main objective of this research was to formulate an analgesic drug incorporated in topically used sticks, prepared using suitable ointment bases with varied concentrations of waxes, lubricants, surfactants, etc. and incorporation of medicament in the optimized formula by heating and congealing process. Indomethacin was the drug of choice used because; this drug if used orally has a lot of side effects which has to be reduced. The main purpose of this formulation was to dispense medicated derma sticks to the patients, specially suffering from rheumatoid arthritis, as Indomethacin is effecti

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Kpoumie, Carolle Laure. "Good To Know." Journal of Clinical Research and Reports 4, no. 2 (2020): 01–02. http://dx.doi.org/10.31579/2690-1919/076.

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What do you know about paracetamol? - Paracetamol is an analgesic (relieves pain) - Paracetamol is an antipyretic (lowers fever) - Paracetamol is hepatotoxic (so if you've been told that you have liver disease, so do not take it, or try to stick to the dose because overdose may damage more your liver, and this overdose would damage the same time even if there is no history of a liver problem - Paracetamol, dosage, always respect it, every 4 hours between taking and even 6 hours in children - Paracetamol, in self-medication, as analgesic, beyond 5 days of pain, and as antipyretic after 3 days o

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Lobo, Clarisse Lopes de Castro, Ana Maria Mach Queiroz, Agueda Gloria Sabino De Matos, Eleonora D'Avila Thome, and Samir K. Ballas. "Efficacy of Lidocaine Patch in Relieving Severe Sickle Cell Leg Ulcer Pain." Blood 126, no. 23 (2015): 4596. http://dx.doi.org/10.1182/blood.v126.23.4596.4596.

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Abstract Introduction: Currently, there is a plethora of analgesics on the market that vary in type, method of application, duration of action, side effects and price. Thus we have, among other things, NSAIDs, opioids, anesthetics, cannabinoids, gases and venom-derived pain relievers. Formulations include short-acting, long-acting, extended release or controlled release. Administration of analgesia could be oral, topical, parenteral, intrathecal, epidural, rectal, intranasal, epidermal, submucosal, sublingual, etc. Despite the abundance of these drugs in the western world, there is an embarras

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Amir, Samah, Samiha Mouftah, Mohammed Omar, and Noura Alfard. "Evaluating Opioid Dispensing Practices: Insights into the Knowledge, Attitudes, and Practices of Libyan Pharmacists at Sabratha Teaching Hospital." University of Zawia Journal of Medical Sciences 1, no. 1 (2025): 8–15. https://doi.org/10.26629/uzjms.2025.02.

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Background: Opioid analgesics are the most potent prescription analgesics. Although there is wide acceptance in prescribing narcotic analgesics for in-patients who have cancer, acceptance is not so universal in treating in-patients with pain from other causes. This study aimed to evaluate the availability of analgesic opioids in Sabratha Teaching Hospital and investigated Libyan pharmacists' knowledge, attitude, and practice towards dispensing these medications. Materials and Methods: Quantitative data on opioid availability were obtained from the hospital pharmacy, while qualitative data were

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Porpaczy, C., C. Zimmermann, R. Steinbach, and K. Redlich. "POS1381 TRANSIENT PERIVASCULAR INFLAMMATION OF THE CAROTID ARTERY (TIPIC) SYNDROME: A RARE CAUSE OF CAROTIDYNIE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1044.1–1044. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4353.

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BackgroundCarotidynie defines localised, unilateral neck pain in the region of the carotid bifurcation and is a relatively frequent event with a myriad of causes.Differential diagnosis include mainly arterial dissection, large vessel vasculitis or local inflammation or surrounding structures (e.g. lymphadenitis). We herein describe a patient with carotidynie caused by a TIPIC syndrome under follow up by ultrasound imaging.MethodsThe logiq S8 from GE2 with 2 different linear probes was used.GE L8-18i-D Hockey Stick probe.ML 6-15-D Matrix probe.Case presentationA 36 year old male patient was ref

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Zeng, Zi, Yan-Xia Duan, and Guo-Min Song. "Non-pharmaceutical intervention and pain management situation for neonatal analgesia." Frontiers of Nursing 7, no. 4 (2020): 299–305. http://dx.doi.org/10.2478/fon-2020-0039.

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Abstract Neonatal pain management is an important issue which should have great attention. More and more researches have proved that neonates can feel pain when undergoes painful procedures such as vaccination, heel stick, and so on, and it will result in short-term and long-term outcomes. So it is very important to manage neonatal pain. This article summarized some non-pharmaceutical interventions, including sucrose or glucose, non-nutritional sucking (NNS), breastfeeding, facilitated tucking (FT), kangaroo mother care (KMC), swaddling, heel warming, sensorial saturation (SS), and music thera

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Pazhani, PharmD, Yogitha, Jennifer Roth, PharmD, BCPS, BCCCP, Vivek Kataria, PharmD, BCCCP, Hoa L. Nguyen, MD, MS, PhD, Adrian Ramos, RN, MSN, AGACNP, and Jennifer Mooney, MD, FACS. "Impact of ketamine versus fentanyl continuous infusion on opioid use in patients admitted to a surgical-trauma intensive care unit." Journal of Opioid Management 18, no. 3 (2022): 257–64. http://dx.doi.org/10.5055/jom.2022.0717.

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Objective: Ketamine has been shown to decrease opioid utilization as an adjunct, but limited evidence is available on ketamine as a primary analgesic strategy.Design: A retrospective chart review.Patients and participants: Mechanically ventilated adult patients (≥18 years) in the surgery-trauma intensive care unit (STICU) with continuous infusion ketamine or fentanyl with concomitant propofol for at least 12 hours were screened for inclusion. The final analysis included 22 patients in the ketamine/propofol (KP) group and 24 patients in the fentanyl/propofol (FP) group.Interventions: Patients i

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Rhein, Lawrence. "Clinical Limitations of Non-pharmacological Comfort Tools for Needle Sticks in Neonatal Intensive Care Units (NICU)." Journal of Clinical Pediatrics 5, no. 1 (2024): 1–10. http://dx.doi.org/10.52338/jocp.2024.3978.

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During a neonate’s stay in the neonatal intensive care unit (NICU), they will undergo many painful, but necessary, procedures to deliver treatment and to monitor physiological status. Many of these methods will involve skin breaks by a needle. While pharmacological analgesics are available for larger procedures like surgeries and intubation, the volume of painful procedures neonates must endure makes the use of pharmacological analgesics impractical for every painful procedure. Due to their immature nervous system, preterm neonates have limited ability to modulate pain. Recent studies have dem

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Jaishetwar, Ganesh S., and Dr Fouqia Mahnaz Khanam. "A cross-sectional study on pain management during vaso-occlusive crisis in sickle cell disease." International Journal of Research in Medical Sciences 11, no. 2 (2023): 600–605. http://dx.doi.org/10.18203/2320-6012.ijrms20230171.

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Background: Sickle cell disease is an inherited hematological disorder characterized by hard and sticky red blood cells that appears like a C-shaped “sickle” in contrast to the healthy, round red blood cells which tend to stick and clog the blood vessels during blood flow leading to pain or vaso-occlusive crisis. Methods: A cross-sectional study was conducted at Yashoda hospital in Hyderabad, India. Data regarding the management of acute pain during VOC in SCD patients was gathered from the hematology department on a daily basis during the duration of the study. The data was recorded in an onl

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Schiavenato, Martin, Meggan Butler-O’Hara, and Paul Scovanner. "Exploring the Association Between Pain Intensity and Facial Display in Term Newborns." Pain Research and Management 16, no. 1 (2011): 10–12. http://dx.doi.org/10.1155/2011/873103.

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BACKGROUND: Facial expression is widely used to judge pain in neonates. However, little is known about the relationship between intensity of the painful stimulus and the nature of the expression in term neonates.OBJECTIVES: To describe differences in the movement of key facial areas between two groups of term neonates experiencing painful stimuli of different intensities.METHODS: Video recordings from two previous studies were used to select study subjects. Four term neonates undergoing circumcision without analgesia were compared with four similar male term neonates undergoing a routine heel

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Baba, Lisa R., Jacqueline M. McGrath, and Jiexin Liu. "The Efficacy of Mechanical Vibration Analgesia for Relief of Heel Stick Pain in Neonates." Journal of Perinatal & Neonatal Nursing 24, no. 3 (2010): 274–83. http://dx.doi.org/10.1097/jpn.0b013e3181ea7350.

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Lowe, Henry, Ngeh Toyang, Blair Steele, Joseph Bryant, Wilfred Ngwa, and Kaveh Nedamat. "The Current and Potential Application of Medicinal Cannabis Products in Dentistry." Dentistry Journal 9, no. 9 (2021): 106. http://dx.doi.org/10.3390/dj9090106.

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Oral and dental diseases are a major global burden, the most common non-communicable diseases (NCDs), and may even affect an individual’s general quality of life and health. The most prevalent dental and oral health conditions are tooth decay (otherwise referred to as dental caries/cavities), oral cancers, gingivitis, periodontitis, periodontal (gum) disease, Noma, oro-dental trauma, oral manifestations of HIV, sensitive teeth, cracked teeth, broken teeth, and congenital anomalies such as cleft lip and palate. Herbs have been utilized for hundreds of years in traditional Chinese, African and I

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McPherson, Mary, Kathryn Walker, and Mina Kim. "Stick It to Me: Topical and Transdermal Analgesics at End of Life (524)." Journal of Pain and Symptom Management 43, no. 2 (2012): 415. http://dx.doi.org/10.1016/j.jpainsymman.2011.12.168.

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Boice, Judith A., Tyler W. Buckner, Stacy E. Croteau, et al. "Assessment of TRM-201 (Rofecoxib) Efficacy and Safety for Chronic Pain in Hemophilic Arthropathy: The Rofecoxib Efficacy and Safety Evaluation Trial in Hemophilic Arthropathy (RESET-HA), a Randomized, Double-Blind Placebo-Controlled Phase III Clinical Trial." Blood 138, Supplement 1 (2021): 4243. http://dx.doi.org/10.1182/blood-2021-154056.

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Abstract Background: Intra-articular bleeding (hemarthrosis) accounts for 80-90% (Roosendaal, et. al. Semin Thromb Hemost . 2003;29:37) of all bleeds and more than 90% of serious bleeding events in patients with severe hemophilia (Valentino. J Thromb Haemost . 2010;8:1895). Recurrent hemarthroses result in progressive joint damage and the development of hemophilic arthropathy (HA) in up to 50% of adults with hemophilia (Forsyth, et al. Haemophilia . 2014;20:44). Acetaminophen is commonly prescribed for pain due to HA yet has limited efficacy at therapeutic doses (Rodriguez-Merchan. Blood Rev.

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Ukrainets, Igor V., Lidiya A. Petrushova, Andrii I. Fedosov та ін. "Crystal Habits and Biological Properties of N-(4-Trifluoromethylphenyl)-4-Hydroxy-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxamide". Scientia Pharmaceutica 88, № 1 (2019): 1. http://dx.doi.org/10.3390/scipharm88010001.

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In order to study polymorphic modifications of N-(4-trifluoromethylphenyl)-4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide, which is of interest as a promising analgesic, its three colorless crystal forms with different habitus have been obtained: sticks of ethyl acetate, plates of meta-xylene and blocks of ortho-xylene. However, the X-ray diffraction analysis has shown that all the forms studied have the identical molecular and crystal structure in spite of such significant differences in appearance. Moreover, pharmacological tests have revealed significant differences in the analges

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Meghani, Salimah H., Eeeseung Byun, and Rollin M. Gallagher. "Time to Take Stock: A Meta-Analysis and Systematic Review of Analgesic Treatment Disparities for Pain in the United States." Pain Medicine 13, no. 2 (2012): 150–74. http://dx.doi.org/10.1111/j.1526-4637.2011.01310.x.

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Abhayraj, Yadav, Dixit Amey, Kumar Sanjay, and Pandey Pranchil. "A Randomised, Controlled Clinical Study Comparing the Effectiveness of Pericapsular Nerve Group (PENG) Block Vs the Fascia Iliaca Compartment (FICB) for Pain Management After Hip Fracture." International Journal of Current Pharmaceutical Review and Research 15, no. 06 (2023): 28–32. https://doi.org/10.5281/zenodo.12581668.

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AbstractIntroduction: Commonly used in hip fracture surgery, fascia iliaca compartment block(FICB) has lately been criticized for providing insufficient pain relief. The effectiveness ofthe innovative pericapsular nerve group block (PENG) technique for hip analgesia is stillbeing debated. The goals of this research were to examine how effectively PENG blockswork at relieving hip fracture pain and how they stack up against FICB.The aim of this study was to determine whether the PENG block is a viable alternative to theFICB for the treatment of hip fracture pain.Methods: Following approval from

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Bennett, Mike, Judith A. Paice, and Mark Wallace. "Pain and Opioids in Cancer Care: Benefits, Risks, and Alternatives." American Society of Clinical Oncology Educational Book, no. 37 (May 2017): 705–13. http://dx.doi.org/10.1200/edbk_180469.

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Pain remains common in the setting of malignancy, occurring as a consequence of cancer and its treatment. Several high-quality studies confirm that more than 50% of all patients with cancer experience moderate to severe pain. The prevalence of pain in cancer survivors is estimated to be 40%, while close to two-thirds of those with advanced disease live with pain. Progress has occurred in the management of cancer pain, yet undertreatment persists. Additionally, new challenges are threatening these advances. These challenges are numerous and include educational deficits, time restraints, and lim

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Zeng, X., X. Leng, K. Wei, et al. "FRI0428 RESULTS FROM A CROSS-SECTIONAL, OBSERVATIONAL STUDY TO ASSESS INADEQUATE PAIN RELIEF IN PATIENTS WITH KNEE AND/OR HIP OSTEOARTHRITIS IN CHINA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 812.1–813. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5813.

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Background:Osteoarthritis (OA) of the knee and hip is a leading cause of disability worldwide, particularly due to the primary symptom of pain in the weight-bearing joints. There is limited data that characterizes patients who experience moderate to severe pain despite analgesic treatment in China.Objectives:This study estimates the real-world prevalence of inadequate pain relief (IPR) among patients with knee and/or hip OA who have been prescribed analgesic therapy and characterizes this patient population. The study was conducted in China, the Philippines, Thailand, Russia, and Mexico. This

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Elendu, Chukwuka, Dependable C. Amaechi, Chisom E. Alakwe-Ojimba, et al. "Understanding Sickle cell disease: Causes, symptoms, and treatment options." Medicine 102, no. 38 (2023): e35237. http://dx.doi.org/10.1097/md.0000000000035237.

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Sickle cell disease (SCD) is a hereditary blood disorder characterized by the production of abnormal hemoglobin molecules that cause red blood cells to take on a crescent or sickle shape. This condition affects millions of people worldwide, particularly those of African, Mediterranean, Middle Eastern, and South Asian descent. This paper aims to provide an overview of SCD by exploring its causes, symptoms, and available treatment options. The primary cause of SCD is a mutation in the gene responsible for producing hemoglobin, the protein that carries oxygen in red blood cells. This mutation has

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Kulo, Adnan, Diela Kulo, Ramajana Sukic-Karalic, et al. "Comparison of Postoperative Morbidity Between Two Tension-Free Hernioplasty Techniques: With Mesh versus Without Mesh." Sarajevo Medical Journal 1, no. 1 (2024): 11–17. http://dx.doi.org/10.70119/0003-24.

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Introduction. Although inguinal hernia surgery is the most common surgical procedure worldwide, the best surgical method is still not universally accepted. The Lichtenstein technique is considered the gold standard, although it also has its limitations. Therefore, there is still a need for new techniques, such as the Desarda technique. The aim of this article is to evaluate and compare the postoperative morbidity of two tension-free techniques for inguinal canal pla-stic surgery with and without the use of mesh. Methods. This prospective randomized clinical study was conducted at the Clinic fo

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Musyrhifatun, Baiq Kholida, and Muhammad Bakhrul Lutfianto. "Evaluation Effect Dexamethason and Paracetamol Post-Odontectomy 38 with Impaction IA Mesioangular." PROCEEDING IMPROVE QUALITY IN DENTISTRY 1, no. 1 (2024): 67–72. http://dx.doi.org/10.18196/imunity.v1i1.10.

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Introduction: Impacted teeth are a pathological situation where a tooth cannot or will not erupt into normal functional position. Odontectomy is one of the most frequently performed procedures and an invasive procedure that involves extensive tissue trauma and a considerable postoperative inflammatory response. However, to achieve adequate pain relief, monotherapy is difficult and multimodal analgesia is now accepted as the cornerstone of effective pain treatment. Objective: This case report was written with the aim of evaluating the effects of dexamethasone combined with paracetamol in post-o

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Ahmed Omar, Abdikadir, Md Sahadat Hossain, Hawo Ali Abdi, and Ibrahim Ali Mohamud. "PREVALENCE OF DYSMENORRHEA AMONG FEMALE STUDENTS ATTENDING SALAAM UNIVERSITY IN MOGADISHU, SOMALIA AND FACTORS ASSOCIATED WITH IT." EDUCATION, SUSTAINABILITY & SOCIETY 4, no. 1 (2021): 11–14. http://dx.doi.org/10.26480/ess.01.2021.11.14.

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Dysmenorrhea is pain associated with menstruation. It’s often an issue discussed in privacy yet continues to affect girls and women with grave impact on their education, social activities and work. Objective: To assess the factors that influence prevalence of dysmenorrhea among university students and factors associated with it in Salaam University in Mogadishu Capital city of Somalia. The study area was Salaam University. A cross sectional study was used to collect data on prevalence of dysmenorrhea among university students and factors associated with it. A self-administered questionnaire no

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Curry, Paul J., and Cheryl M. Hanna. "Comparative Analysis of Post-Operative Continuous Pulse Oximetry Patterns in Midline Abdominal Surgery Patients Receiving Neuraxial or PCA Narcotic Analgesia in a Community Hospital Setting: Sticky Perspectives." Anesthesiology 96, Sup 2 (2002): A1086. http://dx.doi.org/10.1097/00000542-200209002-01086.

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Amreen, Amreen, Asif Iqbal Siddiqui, and Mohd Nauman Saleem. "Devising of Lazūq (A Conventional Unani Dosage Form) with reference to Transdermal Patch; Then and Now: A Critical Review." Journal of Drug Delivery and Therapeutics 14, no. 4 (2024): 155–64. http://dx.doi.org/10.22270/jddt.v14i4.6511.

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Objective: The endeavor is made to criticize the classical indications, preparations and application of Lazūq even after passing many centuries since its inception. Background: According to classical Unani literature, Lazūq is primarily formulated for headache, migraine, toothache, cervical pain, dropping of uvula and different types of pain like sciatica, backache, myalgia and some orthopedic conditions. Its approach is still conventional that encompasses thick sticky stuff of drug/s which is pasted over a cloth or thick paper, consequently, maximum ratio of medicinal properties remains insig

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Adamović, Ana, Mirjana Veselinović, Ana Aničić, et al. "Modern approaches in the treatment of osteoarthritis of the knee." PONS - medicinski casopis 21, no. 1 (2024): 33–39. http://dx.doi.org/10.5937/pomc21-46556.

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Arthrosis is a common, primarily non-inflammatory, chronic, slowly progressing disease of the joints, with the most common localization in the knee joint, which is the main cause of chronic disability. As there is still no treatment that can stop the process of joint degeneration, we can only come up with measures to reduce pain and improve the functionality and quality of life of the patient. The aim of this study is to present recommendations for the treatment of gonarthrosis, with special reference to procedures applied at the level of primary health care. The research was designed as a rev

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Hocking, P. M. "Assessment of the welfare of food restricted broiler breeder males with musculo-skeletal lesions." Proceedings of the British Society of Animal Production (1972) 1993 (March 1993): 231. http://dx.doi.org/10.1017/s0308229600025538.

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Leg disorders in male turkey breeding stock are associated with pain during locomotion (Duncan et al 1990). Musculo-skeletal diseases are prevalent in broiler breeder males and the experiment was designed to evaluate birds of two ages for evidence of pain during movement. Two experiments were conducted, the first examined differences in sexual motivation and the second the rate of walking towards a food reward. At the end of the experiment the birds were killed and the legs dissected to establish the presence of musculoskeletal disease.Commercial broiler breeder males were housed singly with 1

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Jayakumar, Kanisha Chengi Ramaswamy, Ng Sau Chyun, and Md Syazwan bin Md Amin. "THE SILENT REMODELER." Journal of the ASEAN Federation of Endocrine Societies 40, S1 (2025): 25. https://doi.org/10.15605/jafes.040.s1.037.

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INTRODUCTION/BACKGROUND Paget’s disease of bone (PDB) is a metabolic bone disorder characterized by excessive osteoclastic activity, leading to abnormal bone remodeling. PDB is often underdiagnosed, particularly among Southeast Asians and individuals under 40 years old. We report a rare case of PDB in a 48-year-old Malaysian woman presenting with severe complications. CASE The patient, with a history of hypertension, developed progressive shortness of breath and reduced effort tolerance over a week. She had a five-year history of bilateral hip and knee pain, which led her to change jobs from c

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Jones, Wallace, Leann Myers, Aditi Dasgupta, and Jessica Debord. "A Clinical Pathway Reduces Admissions for Vaso-Occlusive Pain in Sickle Cell Disease." Blood 134, Supplement_1 (2019): 3383. http://dx.doi.org/10.1182/blood-2019-127097.

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Vaso-occlusive pain, a primary feature of sickle cell disease (SCD), leads to high acute care utilization, including frequent hospital admission. Though limited by a paucity of high quality evidence, guideline recommendations for the inpatient management of vaso-occlusive pain include rapid and continual pain assessment, early and individualized pain control, and intravenous fluid resuscitation (Yawn et. al. JAMA). However, research suggests that inpatient vaso-occlusive pain management varies significantly within institutions (Co et. al. Jt Comm J Qual Saf). Clinical pathways, which are a mec

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Winangun, Winangun. "DIAGNOSIS DAN TATALAKSANA KOMPREHENSIF OSTEOARTRITIS." JURNAL KEDOKTERAN 5, no. 1 (2019): 125. http://dx.doi.org/10.36679/kedokteran.v5i1.140.

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Rheumatic conditions are composed of arthritis and its allied connective tissue diseases. There arecurrently more than 100 discrete forms of arthritis recognized, the most common being osteoarthritis (OA). Osteoarthritis refers to a clinical syndrome of joint pain accompanied by varying degrees of functional limitation and reduced quality of life. It is the most common form of arthritis, and one of the leading causes of pain and disability world wide. The most commonly affected peripheral joints are the knees, hips and small hand joints. Arthritis and related conditions are the leading cause o

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Kanter, Julie, Amit Shah, Vikas Joshi, et al. "Rare Cases of Infusion-Related Reactions (IRRs) Presenting As Pain Events during or after Crizanlizumab Infusion in Patients (Pts) with Sickle Cell Disease (SCD): A Systematic Evaluation of Post-Marketing (PM) Reports." Blood 138, Supplement 1 (2021): 3112. http://dx.doi.org/10.1182/blood-2021-152362.

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Abstract Background: Vaso-occlusive crises (VOCs) are the hallmark of SCD. VOCs and silent vaso-occlusion can lead to complications (eg acute chest syndrome, hepatic/renal dysfunction, chronic pain, multi-organ failure) and premature death. Crizanlizumab, an anti-P-selectin monoclonal antibody (mAb), is authorized in &gt;40 countries to prevent/reduce VOCs in SCD pts aged ≥16 yrs. IRRs are defined as any signs/symptoms (S/S) experienced by pts during/within 24 hrs of infusion of a pharmacologic/biologic agent. IRRs are quite common with mAbs (frequency 1.6‒99%; Rombouts et al Anticancer Re

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Li, Fengyan, and Guan-Qun Zhou. "Impact of acute therapeutic toxicities on anxiety during radiotherapy among Chinese patients with newly diagnosed nonmetastatic head and neck cancer: A cross-sectional study." Journal of Clinical Oncology 42, no. 23_suppl (2024): 147. http://dx.doi.org/10.1200/jco.2024.42.23_suppl.147.

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147 Background: Head and neck cancer (HNC) poses a significant threat to both psychological and physical health. This study aimed to depict the anxiety status of Chinese newly diagnosed nonmetastatic HNC patients during radiotherapy (RT) and to examine predictors of anxiety symptoms. Methods: Newly diagnosed nonmetastatic HNC patients who received RT at the Radiation Therapy Center of Sun Yat-sen University Cancer Center from August 23,2023 to August 24,2023 were recruited into this study. Using Zung Self-Rating Anxiety Scale (Zung SAS) to screen anxiety. Twenty-four common acute therapeutic t

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1Dr., Saikrishna Rengerla 2Dr. Akhil Lohkare 3Dr. CM Badole. "FUNCTIONAL OUTCOME OF BIPOLAR HEMIARTHROPLASTY IN DISPLACED INTRACAPSULAR FEMORAL NECK FRACTURE IN ELDERLY IN RURAL TERTIARY HOSPITAL." International Journal of Medical Science in Clinical Research and Review 05, no. 05 (2022): 609–18. https://doi.org/10.5281/zenodo.7100486.

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Original Research Paper FUNCTIONAL OUTCOME OF BIPOLAR HEMIARTHROPLASTY IN DISPLACED INTRACAPSULAR FEMORAL NECK FRACTURE IN ELDERLY IN RURAL TERTIARY HOSPITAL <strong>Authors:</strong> <strong><sup>1</sup></strong><strong>Dr. Saikrishna Rengerla</strong><strong>, </strong><strong><sup>2</sup></strong><strong>Dr. Akhil Lohkare, <sup>3</sup>Dr. CM Badole</strong> <em><sup>1,2</sup></em><em>Senior Resident, Dept of Orthopaedics, MGIMS Sevagram</em> <em><sup>3</sup></em><em>Director-Professor & HOD, Dept of Orthopaedics, MGIMS Sevagram</em> Corresponding Author: Dr. Saikrishna Rengerla, Dept of

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Nagalakshmi.R*, Surinder Kaur. "FORMULATION AND EVALUATION OF MEDICATED ANALGESIC STICKS." September 30, 2017. https://doi.org/10.5281/zenodo.2526913.

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The main objective of this research was to formulate an analgesic drug incorporated in topically used sticks, prepared using suitable ointment bases with varied concentrations of waxes, lubricants, surfactants, etc. and incorporation of medicament in the optimized formula by heating and congealing process. Indomethacin was the drug of choice used because; this drug if used orally has a lot of side effects which has to be reduced. The main purpose of this formulation was to dispense medicated derma sticks to the patients, specially suffering from rheumatoid arthritis, as Indomethacin is effecti

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Wang, Yu, Linping Zhang, Wenbin Dong, and Rong Zhang. "Effects of Kangaroo Mother Care on Repeated Procedural Pain and Cerebral Oxygenation in Preterm Infants." American Journal of Perinatology, June 30, 2021. http://dx.doi.org/10.1055/s-0041-1731650.

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Objective The study aimed to investigate the effects of kangaroo mother care (KMC) on repeated procedural pain and cerebral oxygenation in preterm infants. Study Design Preterm infants of 31 to 33 weeks of gestational age were randomly divided into an intervention group (n = 36) and a control group (n = 37). Premature infant pain profile (PIPP) scores, heart rate, oxygen saturation, regional cerebral tissue oxygenation saturation (rcSO2), and cerebral fractional tissue oxygen extraction (cFTOE) were evaluated during repeated heel stick procedures. Each heel stick procedure included three phase

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de Leeuw, Matthijs, Mirjam Laager, Jens Gaab, Wilhelm Ruppen, and Tobias Schneider. "Boosting open-label placebo effects in acute induced pain in healthy adults (BOLPAP-study): study protocol of a randomized controlled trial." Frontiers in Medicine 11 (February 14, 2024). http://dx.doi.org/10.3389/fmed.2024.1238878.

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IntroductionPain is a highly prevalent symptom in the hospital setting, but treatment options remain limited. Harnessing the placebo effect in an ethical manner could provide a new possibility to reduce pain in clinical practice. So called open-label placebos (OLP) have been shown to elicit significant effects in reducing acute pain. But, before implementation, more knowledge concerning the properties of OLPs is needed. This study aims to assess the duration of analgesic effects from OLP and to determine the possibility of boosting such effects.Methods and analysisThis is the protocol of an on

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Ziaei, Maryam, and Ali Abdolrazaghnejad. "The analgesic effect of intranasal ketamine and intravenous morphine in patients with flank pain (renal colic) in the emergency department; a clinical trial study." Immunopathologia Persa, January 16, 2022. http://dx.doi.org/10.34172/ipp.2022.29271.

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Introduction: Renal colic is the most common clinical manifestation of urinary stones. Objectives: This study was aimed to compare the effect of intranasal ketamine versus intravenous morphine on renal colic. Patients and Methods: In this clinical trial study, 100 patients with renal colic were entered into the study and randomly divided into two groups. Patients in treatment group received intranasal ketamine (1.5 mg/kg) and the other group was given intravenous morphine (0.1 mg/kg). The pain was measured at 0, 5, 15, 30 and 60 minutes after therapy. Results: In this study, 32% of patients we

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Akbari, Negarin, Birsen Mutlu, and Javad Nadali. "Effect of Non-Nutritive Sucking During Heel Stick Procedure in Pain Management of Term Infants in the Neonatal Intensive Care Unit: A Systematic Review and Meta-Analysis." Current Pediatric Reviews 18 (April 10, 2022). http://dx.doi.org/10.2174/1573396318666220410225908.

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Background: The objective of this study was to evaluate the efficacy of non-nutritive sucking for analgesia in term infants undergoing heel-stick procedures. Methods: Randomized controlled trials and non-randomized studies based on the PICO framework were included in the study. Review articles, commentary, pilot, and non-English articles were excluded. Databases such as PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane were searched until January 31, 2021, using the keywords “Pain management,” ‘Non-nutritive sucking,” and “Heel stick.” All studies were reviewed and retrieved by two

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Lauder, Jean K., Sonia Marti, Karen S. Schwartzkopf-Genswein, Murray D. Jelinski, and Eugene D. Janzen. "Measuring behavioral and physiological responses to pain mitigation for ovariectomy in Bos taurus yearling beef heifers." Journal of Animal Science 98, no. 1 (2019). http://dx.doi.org/10.1093/jas/skz386.

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Abstract Ovariectomy (spaying) using the trans-vaginal dropped ovary technique (DOT) is performed to prevent pregnancy in cull female beef cattle that are not retained for breeding stock in areas practicing extensive grazing management. There are no reports describing analgesia for this surgical procedure. The objective of this study was to measure behavioral and physiological responses to determine whether an analgesic protocol of BXK [butorphanol (0.01 mg/kg), xylazine (0.02 mg/kg), and ketamine (0.04 mg/kg)] injected intramuscularly (i.m.) before spaying could mitigate procedural and immedi

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NUR, Gökhan, Büşra Nur BARIŞ, Büşra LEVENT, Buse Selin SAZAKLIOĞLU, and Elvan AK. "BUSER Transcutaneous Electric Nerve Stimulator Device Design." Natural and Engineering Sciences, April 6, 2023, 18–30. http://dx.doi.org/10.28978/nesciences.1278068.

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The Transcutaneous Electrical Nerve Stimulator (TENS) is one of the medical devices that uses electricity to stimulate the nerve and produce analgesic effects. A TENS device is a small battery-powered or city-powered device with ends attached to sticky pads called electrodes. TENS, with its main purpose of helping to reduce pain and muscle spasms, has a wide usage area, especially in arthritis, fibromyalgia, chronic pelvic pain, knee pain, menstrual pain, low back pain, sports injuries, and atrophic muscle tissue cases. In this study, a Transcutaneous electrical stimulation device, which is on

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Conaghan, Philip G., Ali Guermazi, Nathaniel Katz, et al. "OA04 A randomised controlled Phase II trial of LEVI-04, a novel neurotrophin-3 inhibitor, in knee osteoarthritis demonstrates substantially improved pain and function without deleterious effects on joint structure." Rheumatology 64, Supplement_3 (2025). https://doi.org/10.1093/rheumatology/keaf142.004.

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Abstract Background/Aims There is an urgent need for new OA therapies. Excess neurotrophins are implicated in OA pain. Previous OA therapies selectively targeting NGF provided analgesia but resulted in significant joint pathologies. LEVI-04, a p75NTR-Fc, first-in-class fusion protein, supplements endogenous p75NTR, inhibiting neurotrophin-3 and modulating neurotrophin levels. Preclinical studies supported efficacy and Phase I trials demonstrated safety. This phase II RCT aimed to assess efficacy and safety in people with knee OA. Methods This was a 20-week Phase II multicentre RCT in people wi

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Fioccola, Antonio, and Conor John Skerritt. "Ultrasound-guided flexor sheath block as a valid alternative to blind techniques for finger pain treatment: the horseshoe sign." Regional Anesthesia & Pain Medicine, March 14, 2023, rapm—2023–104372. http://dx.doi.org/10.1136/rapm-2023-104372.

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BackgroundThe flexor sheath digital block allows effective analgesia and anesthesia for finger pain control. To date, only blind techniques are described in the literature in patients with finger fractures, supposedly due to the superficial position of the structures used as landmarks. We describe an ultrasound-guided technique with a definite endpoint to achieve this block. To our knowledge, this is the first clinical application of this procedure.MethodsWe performed a preoperative ultrasound-guided flexor sheath digital block on a young patient with a proximal phalanx fracture, undergoing an

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Kishori, Ms, Sharin Thomas, Ms Sowparnika, et al. "Formulation and Evaluation of Ibuprofen Gel." International Journal of Pharmaceutical Sciences Review and Research, July 15, 2022, 176–78. http://dx.doi.org/10.47583/ijpsrr.2022.v75i01.029.

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Topical drug delivery systems are gaining increase in the popularity and several drugs have been successful delivered by this route for both local & systemic action. In recent years most NSAIDs have been designed to deliver the drug in the form of topical gels, to avoid gastrointestinal irritation, to overcome “first pass” effect and to maximize the drug concentration at the site of action. Ibuprofen have been shown to have potent analgesic effect & anti-inflammatory activities, similar to Indomethacin and Diclofenac and due to its preferential CO-X blockade, it has been better safety

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Derstadt, Marie, Panagiotis Thomaidis, Claudia S. Seefeldt, et al. "Transvaginal hybrid-NOTES vs. traditional laparoscopic sigmoid resection for diverticulitis: a short-term comparative study." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-79461-1.

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AbstractThe aim was to compare short-term results of transvaginal hybrid-NOTES (NSR) with traditional laparoscopic technique in sigmoid resection (LSR) in cases of diverticulitis. Natural Orifice Transluminal Endoscopic Surgery has been evolved as a minimally invasive procedure to reduce the operative trauma due to the absence of specimen extraction through the abdominal wall causing less postoperative pain, and shorter hospital stay. Despite the increasing use and published case series of NSR for diverticulitis as a laparoscopic procedure with transvaginal stapling and specimen extraction, th

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Law, Amber, Soraya Koushesh, Abiola Harrison, et al. "E045 Role of Thrombospondin-4 in pain sensitisation of knee osteoarthritis in relation to semi-automated joint space measures in routine radiographs." Rheumatology 64, Supplement_3 (2025). https://doi.org/10.1093/rheumatology/keaf142.281.

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Abstract Background/Aims Pain and stiffness in knee osteoarthritis (OA) is linked to inflammation and structural damage. The source of OA pain is not fully established and a better understanding is required for individually optimised treatments. Many patients cycle through treatments including analgesics and steroid injections but those with pain sensitisation may be less responsive to conventional therapies. Thrombospondin-4 (TSP-4) is a glycoprotein found in the extra-cellular matrix and neuromuscular junction. Its increased expression promotes neuropathic pain and central sensitisation in r

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Raman, Rajendra, and Laura Fleming. "We Need to Talk About Codeine: an Implementation Study to reduce the number of Emergency Department patients discharged on high-strength co-codamol using the Behaviour Change Wheel." Emergency Medicine Journal, March 3, 2021, emermed-2020-209479. http://dx.doi.org/10.1136/emermed-2020-209479.

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BackgroundThe crisis of prescription opioid addiction in the USA is well-documented. Though opioid consumption per capita is lower in the UK, prescribing has increased dramatically in recent decades with an associated increase in deaths from prescription opioid overdose. At one Scottish Emergency Department high rates of prescribing of take-home co-codamol (30/500 mg) were observed, including for conditions where opioids are not recommended by national guidelines. An Implementation Science approach was adopted to investigate this.MethodsA Behaviour Change Wheel analysis suggested several facto

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Wawryków, Agata, and Katarzyna Korabiusz. "Transcutaneous Electrical Nerve Stimulation as a method to relieve pain during childbirth." September 7, 2018. https://doi.org/10.5281/zenodo.1411112.

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<strong>Wawryków Agata, Korabiusz Katarzyna. Transcutaneous Electrical Nerve Stimulation as a method to relieve pain during childbirth. </strong><strong>Journal </strong><strong>of Education, Health and Sport. 2018;8(9):543-548 eISNN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.1411112</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/article/view/5923</strong> <strong>https://pbn.nauka.gov.pl/sedno-webapp/works/876367</strong>           <strong>The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation

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Donnez, Jacques, Christian Becker, Hugh Taylor, et al. "Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3)." Human Reproduction, April 22, 2024. http://dx.doi.org/10.1093/humrep/deae076.

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Abstract STUDY QUESTION Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone acetate [NETA]) demonstrate better efficacy than placebo in the management of endometriosis-related dysmenorrhea and non-menstrual pelvic pain? SUMMARY ANSWER Combining 200 mg linzagolix with ABT was found to significantly reduce dysmenorrhea and non-menstrual pelvic pain at 3 months of therapy, while a daily dose of 75 mg linzagolix yielded a signific

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Soled, Derek. "Distributive Justice as a Means of Combating Systemic Racism in Healthcare." Voices in Bioethics 7 (June 21, 2021). http://dx.doi.org/10.52214/vib.v7i.8502.

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Photo by Sharon McCutcheon on Unsplash ABSTRACT COVID-19 highlighted a disproportionate impact upon marginalized communities that needs to be addressed. Specifically, a focus on equity rather than equality would better address and prevent the disparities seen in COVID-19. A distributive justice framework can provide this great benefit but will succeed only if the medical community engages in outreach, anti-racism measures, and listens to communities in need. INTRODUCTION COVID-19 disproportionately impacted communities of color and lower socioeconomic status, sparking p

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Brien, Donna Lee. "Just the Sort of Day Jack Had Always Loved." M/C Journal 2, no. 8 (1999). http://dx.doi.org/10.5204/mcj.1811.

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Edith and John Power were a wealthy expatriate Australian couple who lived in England and Europe from the early years of the 20th century until their deaths. In 1915 John Power married Edith Lee in London before serving as a surgeon on the Western Front in the Royal Army Medical Corps. After the war Edith and John left Britain to live in Paris and Brussels in the centre of a large international group of avant-garde artists. Edith, who was twelve years older than her husband, and had been married twice before (once widowed and once divorced), was to all accounts the driving force behind John's

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