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Turama, Dwilanda E., Widdhi Bodhi, and Imam Jayanto. "UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN KUCAI (Allium tuberosum) PADA TIKUS PUTIH JANTAN (Rattus norvegicus)." PHARMACON 9, no. 3 (August 9, 2020): 413. http://dx.doi.org/10.35799/pha.9.2020.30026.
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ABSTRACTKucai (Allium tuberosum) leaves contain metabolite compounds such as alkaloids, saponins, tannis which are potential sources to be developed as medical plants. Flavonoid is a derivative pf a phenol that has an analgesic properties. This study aims to determine whether there is an analgesic effect on the ethanol extract of kucai leaves. This study uses a laboratory experimental research design using wistar strain male white rats as an experiment animal. The ethanol extract of kucai leaves are given with different doses, group 1 doses 3,6 mg, group 2 doses 7,2 mg and group 3 doses 14,4 mg. Stimulation method in rats was carried out by using a 55°C hot plate. Rats was observed before and after giving test material at 30, 60, 90 and 120 minutes respectively and observed their responses by the form of licking legs and jumping. From the result of data in the form of tables and charts show that the ethanol extract of kucai leaves with doses 3,6 mg, 7,2 mg, and 14,4 mg has analgesic effect. It can be concluded that the best analgesic effect of doses is doses 14,4 mg.Keyword : Analgesic, kucai, male white ratsABSTRAK Daun Kucai (Allium tuberosum) memiliki kandungan senyawa metabolit seperti alkaloid, saponin, tanin, dan flavonoid yang merupakan sumber potensial untuk dikembangkan sebagai tanaman obat. Flavonoid merupakan turunan senyawa fenol yang memiliki sifat analgetik. Penelitian ini bertujuan untuk mengetahui adanya efek analgesik dari ekstrak etanol daun kucai. Penelitian ini menggunakan Rancangan Penelitian eksperimental laboratorium menggunakan tikus putih jantan galur wistar sebagai hewan percobaan. Ekstrak etanol daun kucai diberikan dengan dosis yang berbeda-beda yaitu kelompok perlakuan 1 dengan dosis 3,6 mg, perlakuan 2 dengan dosis 7,2 mg, perlakuan 3 dengan dosis 14,4 mg. Metode rangsangan pada tikus dilakukan dengan menggunakan hot plate dengan suhu 550C. Tikus di amati sebelum dan setelah pemberian bahan uji, menit ke 30, 60, 90, dan 120. Respon tikus yang diamati berupa menjilat kaki dan melompat. Dari hasil analisis data dalam bentuk tabel, grafik dan diagram menunjukkan bahwa ekstrak etanol daun kucai dengan dosis 3,6 mg, 7,2 mg, dan 14,4 mg memiliki efek analgesik. Dapat disimpulkan bahwa dosis yang memiliki efek analgesik terbaik ialah dosis 14,4 mg.Kata kunci: Analgesik, kucai, tikus putih jantan
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Mashuri Yusuf, Lilik Koernia Wahidah, Subur Widodo, Puspita Gita Sari, and Mohammad Kanedi. "Analgesic activity of the combined extract of sukun (Artocarpus altilis) and melinjo (Gnetum gnemon L.) Leaves in mice." GSC Biological and Pharmaceutical Sciences 13, no. 1 (October 30, 2020): 244–50. http://dx.doi.org/10.30574/gscbps.202013.1.344.
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Analgesic is any drug used to achieve analgesia—relieve from pain, without blocking the conduction of nerve impulses. Sukun (Artocarpusaltilis) and melinjo (Gnetumgnemon L.) are plants that can be expected to have analgesic properties because they contain bioactive that can inhibit biosynthesis of prostaglandins, a hormone-like pain reducing agent. To determine analgesic effect of two plants in question, the combination extract of melinjo and sukun leaves were treated to mice by applying writhing test. Male mice (n=28) were grouped into seven consisted of two control groups (negative dan positive) and five test groups. The negative control group (KN) received CMC 0.5%, the positive control mice received 1.3 mg/kg BW mefenamic acid. Test groups were given leaf extracts of sukun and melinjo with the dose ratios (sukun : melinjo) as follows (200: 0), (150 : 50), (100 : 100 ), (50 : 150), and (0 : 200) mg/kg BW respectively. After 15 minutes all mice were pain-induced with 1% acetic acid intraperitoneally. Stretching activity of the animals was observed every 5 minutes for 1 hour. The result showed that the extracts with a dose ratio of (150 + 50) mg/kg BW has a comparable anlgesic effects to the mefenamic acid is the most effective combination among other comination doses.
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Rali, Sibusiso, Opeoluwa O. Oyedeji, Olukayode O. Aremu, Adebola O. Oyedeji, and Benedicta N. Nkeh-Chungag. "Semisynthesis of Derivatives of Oleanolic Acid fromSyzygium aromaticumand Their Antinociceptive and Anti-Inflammatory Properties." Mediators of Inflammation 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/8401843.
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Oleanolic acid is a pentacyclic triterpenoid compound widely found in plants and well known for its medicinal properties. Oleanolic acid (OA) was isolated from the ethyl acetate extract ofSyzygium aromaticumflower buds. Semisynthesis afforded both acetate and ester derivatives. The derived compounds were monitored with thin layer chromatography and confirmed with nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), Fourier infrared (FT-IR) spectroscopy, and melting point (Mp). All these compounds were evaluated for their analgesic and anti-inflammatory properties at a dose of 40 mg/kg. Significant analgesic and anti-inflammatory effects were noted for all OA-derived compounds. In the formalin-induced pain test, the derivatives showed better analgesic effects compared to their precursor, whereas, in the tale flick test, oleanolic acid proved to be superior in analgesic effects compared to all its derivatives with the exception of the acetyl derivative. Acute inflammatory tests showed that acetyl derivatives possessed better anti-inflammatory activity compared to the other compounds. In conclusion, semisynthesis of oleanolic acid yielded several derivatives with improved solubility and enhanced analgesic and anti-inflammatory properties.
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Lisa, Susmita Roy, Mohammad Kaisarul Islam, and Nazmul Qais. "Plants and Plant Constituents with Analgesic and Anti-inflammatory Activities: A Systematic Review." Dhaka University Journal of Pharmaceutical Sciences 19, no. 2 (December 10, 2020): 207–24. http://dx.doi.org/10.3329/dujps.v19i2.50638.
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Medicinal plants with potential therapeutic activities are a tremendous resources of prospective drug candidates. NSAIDs, opiates, and other anti-inflammatory & analgesic agents exhibit several unwanted side-effects. Thus, the development of new active compounds with minimum adverse effects necessitates an emergence. This study aims to provide a comprehensive summary of plant species and reported phytoconstituents with analgesic and inti-inflammatory activities. Eighty-seven species from fifty-two plant families with reported constituents and activities have been included in this review. In-depth research in the area of screening novel analgesic and antiinflammatory agents from natural sources followed by the investigation of their pharmacological properties and clinical applications may lead to the generation of new active agents with better therapeutic activity and selectivity in the future.
Dhaka Univ. J. Pharm. Sci. 19(2): 207-224, 2020 (December)
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Morozova, Ekaterina A., Tatiana G. Tolstikova, Alexey V. Bolkunov, Margarita P. Dolgikh, and Elvira E. Shul'ts. "Analgesic Properties of New Pyrrolidinomorphinane Derivatives: Revealing Potential Pathways." Natural Product Communications 3, no. 10 (October 2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301008.
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The pyrrolidinomorphinane derivatives have been found to be active in the writhing tests in mice with the analgesic effect being antagonized by naloxone. This suggests that analgesia is mediated by the opioid system. The compounds also displayed anti-inflammatory activity in formalin and histamine edema experimental models and the data may be evidence for anti-inflammatory activity involvement in the inhibition of pain reaction.
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Shi, Ning-Ning, Cong-Cong Hou, Yan Liu, Kun-Yao Li, Sheng-Dan Mi, Bin-Liang Tong, and Man-Li Zhang. "Chemical constituents of plants from the genus Carpesium." Heterocyclic Communications 28, no. 1 (January 1, 2022): 95–123. http://dx.doi.org/10.1515/hc-2022-0012.
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Abstract Carpesium (Family – Compositae) is a genus with 24 species of mainly perennial herbs. Several species of this genus have served as folk medicine in China and Korea for their antipyretic, anti-inflammatory, analgesic, antifungal, antibacterial, and cytotoxic activity properties. Chemical constituents are mostly sesquiterpenes, diterpenes, glycosides, and several other types of compounds. This article summarizes the literature on the isolated and identified constituents from various Carpesium species and their various biological activities.
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Dinesh Babu J. "Evaluation of antipyretic activity of Capsicum annuum by Brewer’s yeast method." International Journal of Research in Phytochemistry and Pharmacology 9, no. 1 (June 29, 2020): 11–13. http://dx.doi.org/10.26452/ijrpp.v9i1.1185.
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Plants are being used in medicine and treatment of diseases from years in the evolution. During the development of science, investigations to establish eh scientific proof and validation for the activities and mechanism of herbs to treat diseases. Capsicum annuum has anti-cancer properties, analgesic properties, anti lithogenic and thermogenic properties. It is used to alter the gastrointestinal function and boost metabolism. Many formulations are enriched with capsaicin which is a crucial ingredient in Capsicum to exhibit its weight loss properties. Based on the anti-inflammatory and analgesic properties of the plant and taking into consideration, the current research will focus on the investigation and comparison of the antipyretic activity of Capsicum in fruits and leaves. Results show that the leaves have similar chemical constituents that had antipyretic potential compared to the fruits. Overall, the Capsicum showed a comparatively same activity with the standard drug, paracetamol.
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Amoateng, Patrick, Emmanuel Quansah, Thomas K. Karikari, Alex Asase, Dorcas Osei-Safo, Kennedy Kwami Edem Kukuia, Isaac Kingsley Amponsah, and Alexander K. Nyarko. "Medicinal Plants Used in the Treatment of Mental and Neurological Disorders in Ghana." Evidence-Based Complementary and Alternative Medicine 2018 (December 20, 2018): 1–14. http://dx.doi.org/10.1155/2018/8590381.
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Ethnopharmacological Relevance. Mental and neurological disorders are a serious public health challenge globally, particularly in developing countries where cultural factors and limited access to standard healthcare have led to a reliance on traditional medicines. However, ethnopharmacological characterization of traditional medicines used to treat these diseases is lacking. In this study, an ethnobotanical description of plant species used in treating mental and neurological disorders in Ghana and an update of their experimentally validated pharmacological relevance are provided. Materials and Methods. Two hundred herbalists agreed to participate but sixty-six specialized in treating mental and neurological disorders were interviewed on their traditional medical practice. Literature review was conducted to verify the experimentally validated pharmacological importance of the reported plants. Results. Thirty-two plant species belonging to twenty-eight families were identified. Most plant species had either analgesic (50%), anxiolytic (18.8%), or anticonvulsant (15.6%) properties. Others had reported sedative, anti-Alzheimer’s disease, motor coordination, antipsychotic, antidepressant, cognitive enhancement, and neuroprotective properties. While Ageratum conyzoides L. (Asteraceae) and Ocimum gratissimum L. (Lamiaceae) were the most commonly mentioned species with analgesic properties, Lantana camara L. (Verbenaceae) was the most-reported anxiolytic product, with Cymbopogon citratus DC. (Gramineae), Mangifera indica L., Tetrapleura tetraptera Schum Taub. (Fabaceae), and Persea Americana Mill (Lauraceae) being the most studied anticonvulsants. Conclusions. This study provides the first report specifically on medicinal plants used in treating mental and neurological disorders in Ghana. Most of the identified plants have been scientifically confirmed to possess neuro- and psychopharmacological properties and may serve as templates for drug development.
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Makonnen, Eyasu, Asfaw Debella, Dawit Abebe, and Frehiwot Teka. "Analgesic properties of some ethiopian medicinal plants in different models of nociception in mice." Phytotherapy Research 17, no. 9 (2003): 1108–12. http://dx.doi.org/10.1002/ptr.1306.
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Maliha Sami, Abid Rashid, Muhammad Akram, Atheer Kadhim Ibadi, and El Hadji Seydou Mbaye. "Phytochemical analysis and therapeutic properties of medicinal plants Crocus sativus: saffron." World Journal of Advanced Research and Reviews 16, no. 2 (November 30, 2022): 1117–22. http://dx.doi.org/10.30574/wjarr.2022.16.2.1277.
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Crocus sativus Linn (Iridaceae) is well-known for its various domestic and medicinal uses throughout the tropics and subtropics. This plant is helpful because it contains various compounds, including crocetin, crocin, and other flavonoids, which may be used to cure various illnesses. These compounds, particularly crocin, have depressive and anti-inflammatory characteristics, as well as anticancer, analgesic, and other therapeutic effects on various areas of the body, including the heart, respiratory system, genital-urinary system, and central nervous system. According to research and observations, chemoprevention, cell proliferation, antioxidant and obesity effects, apoptosis, lipid peroxidation, and anti-inflammatory processes all have a role in saffron's involvement in treating various food allergies. Since ancient times, saffron has been utilized in traditional medicine in India and other Asian nations. Chemical compounds have been researched for a range of qualities, with many studies focusing on the chemicals found in, or even the medicinal components of, plants.
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Chandwani, Ankita S., Shailja B. Jhala, Karuna P. Modi, and Mamta B. Shah. "PHYTOCHEMICAL AND BIOLOGICAL PROPERTIES OF GENUS PLEUROSPERMUM: A REVIEW." International Journal of Research in Ayurveda and Pharmacy 13, no. 3 (June 7, 2022): 126–31. http://dx.doi.org/10.7897/2277-4343.130373.
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Pleurospermum genus (family Apiaceae) comprises about 80 species native to India, Yunnan, China and Nepal. The plants of this species have long been used in traditional medicine systems to treat various illnesses. Different species are rich in coumarins, saponins, flavonoid glycosides, fatty acids and terpenoids. The extract of this genus and pure compounds isolated from it have been demonstrated to possess multiple pharmacological activities such as analgesic, anti-inflammatory, anticancer, antihyperlipidemic, immunomodulatory, neuroprotective, antimicrobial, antioxidant, etc. The present literature survey was performed exhaustively using databases such as SciFinder, Google Scholar, PubMed, Web of Science, ScienceDirect, and other resources. By corroborating the traditional uses and biological activities of Pleurospermum species, we hope to support new research on these plants, especially on those species whose biological properties have not been studied.
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Zheng, Guangjin, Tieyu Chen, Xing Peng, and Shengjing Long. "Synthesis, Anti-Inflammatory, and Analgesic Activities of Derivatives of 4-Hydroxy-2-benzoxazolone." Journal of Chemistry 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/534156.
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Benzoxazolones are widely distributed in plants and are of increasing interest for a variety of pharmacological properties, such as detoxification, antibacterial, anti-inflammatory, and analgesic activities and tranquilizers (Michaelidou and Hadjipavlou-Litina, 2005; Doğruer et al., 1998). 4-Hydroxy-2-benzoxazolone (HBOA) is one of the major bioactive compounds in traditional Chinese herb drugAcanthus ilicifolius (Peng and Long, 2006) which has obvious anti-inflammatory and analgesic activities (Huo et al., 2004; Mani Senthil Kumar et al., 2008; Babu et al., 2001). In this research, we used 2-nitroresorcinol as starting material to prepare HBOA with a novel “one-pot-way.” Derivatives of HBOA TC-2∼TC-4 were obtained via electrophilic reagents and reacted with corresponding primary amines to afford Schiff Base derivatives TC-5∼TC-10 for further study. Anti-inflammatory and analgesic activities of those derivatives were determined by using carrageenan-induced rat paw edema test. The analgesic activities of the derivatives were determined by the hot-plate test.
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OLESIŃSKA, KATARZYNA. "Sesquiterpene lactones – occurrence and biological properties. A review." Agronomy Science 73, no. 3 (November 29, 2018): 83–95. http://dx.doi.org/10.24326/asx.2018.3.7.
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Sesquiterpene lactones are secondary metabolites commonly found in higher plants as well as mosses, lichens, and fungi. Currently, over 5000 of such compounds have been identified with a majority isolated from Asteraceae plants. They are characterised by different chemical structures associated with the presence of various carbon pathways and functional groups, which exert an impact on their pharmacological activity. These colourless substances are soluble in fats, alcohols, or water. They are often bitter ingredients regarded as bitter compounds. They are accumulated mainly in leaves, flower parts and seeds; less frequently, they are present in roots. Sesquiterpene lactones exhibit multidirectional biological activity: some of them have anticancer, anti-inflammatory, antidiabetic, analgesic, antiparasitic, antifungal, and bacteriostatic effects. Therefore, high hopes are placed on the medical and pharmaceutical use of these substances. Lactone compounds are also regarded as a potential source of new active substances used in agriculture to combat plant pathogens
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Ibrahim, Mohammed, Md Ruhul Kuddus, Md Aslam Hossain, Muhammad Abdullah Al Mansur, and Mohammad A. Rashid. "Preliminary Phytochemical Screenings and Pharmacological Activities of Three Medicinal Plants of Bangladesh." Dhaka University Journal of Pharmaceutical Sciences 16, no. 2 (January 10, 2018): 195–203. http://dx.doi.org/10.3329/dujps.v16i2.35257.
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The present study was designed to evaluate the preliminary phytochemical screening and antimicrobial, antidiarrheal, anti-inflammatory, analgesic, antipyretic, anxiolytic, thrombolytic and membrane stabilizing properties of the methanolic extract of three medicinal plants Perilla ocymoides L., Murraya koenigii (Linn.) Spreng., Baliospermum montanum (Wild.) Muell growing in Bangladesh. In antimicrobial test, maximum zone of inhibition was found against Salmonella typhi (18.0 mm) and Escherichia coli (17.0 mm) by B. montanum extract. In the castor oil-induced antidiarrheal assay, the methanol extract of M. koenigii showed maximum 50% inhibition of defecation. During in-vitro anti-inflammatory test, the methanol extract of B. montanum at 500 μg/ml, b.w. revealed 39.62% inhibition of protein denaturation. Due to analgesia, the M. koenigii extract showed 53.29% inhibition of acetic acidinduced writhing reflex in experimental mice. Antipyretic effect of P. ocymoides, M. Koenigii and B. montanum extractives was assessed by Brewer’s yeast-induced pyrexia in mice. The B. montanum extract possesses significant anxiolytic effect that was evidenced by both hole cross test and open field test in mice. In thrombolytic assay, the highest activity (57.81%) was observed by B. montanum extract. Results of the preliminary phytochemical screenings demonstrated the presence of alkaloids, glycosides, flavonoids, reducing sugars, gums etc.Dhaka Univ. J. Pharm. Sci. 16(2): 195-203, 2017 (December)
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Karande, K. A., S. K. Attar, S. S. Jadhav, N. D. Gidde, K. V. Gaikwad, and R. S. Mistry. "Review On: Medicinal Uses, Phytochemistry And Pharmacological Action Of The Plant Bauhinia Racemosa (Lam.)." Journal of University of Shanghai for Science and Technology 23, no. 11 (November 2, 2021): 951–61. http://dx.doi.org/10.51201/jusst/21/11964.
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Herbal medicines are now attracting attention as potential sources to treat so many diseases or disorders. Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. Bauhinia racemosa (Lam.) belongs to family Caesalpiniaceae, is a small deciduous tree with drooping branches. This plant grows in poor and very harsh climatic conditions the leaves and stem bark of the plant Bauhinia racemosa (Lam.) are usefull in headache, dysentery, diarrhoea, skin disease, fever and blood diseases. The plant reported to have antiulcer, antidiabetic, anticoagulant, hyperlipidemia, antitumor, antimicrobial, antioxidant, antianxiety, anthelmintic, analgesic, antipyretic, antihistaminic, anti-inflammatory, and hepatoprotective properties. The plant reported to have antiulcer, antidiabetic, anticoagulant, hyperlipidemia, antitumor, antimicrobial, antioxidant, antianxiety, anthelmintic, analgesic, antipyretic, antihistaminic, anti-inflammatory, and hepatoprotective properties. This review provides detailed information on plant Bauhinia racemosa (Lam.).
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Bolotova, Ya V. "Aquatic plants of the Far East of Russia: a review on their use in medicine, pharmacological activity." Bangladesh Journal of Medical Science 14, no. 1 (January 9, 2015): 9–13. http://dx.doi.org/10.3329/bjms.v14i1.21554.
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The review provides information on the medicine application of 30 aquatic plant taxa growing in the Russian Far East, and the prospects for their practical use. A list of aquatic plants on the pharmacotherapeutic action is done. The greatest number of species of aquatic plants has analgesic, antipyretic, anti-inflammatory, stomach and antidiarrheal, wound-healing properties. It is revealed that the most widely in traditional medicine in Asia and Europe are used Nelumbo nucifera, Trapa natans, representatives of the family Lemnaceae, Nymphaeaceae, genus Potamogeton. DOI: http://dx.doi.org/10.3329/bjms.v14i1.21554 Bangladesh Journal of Medical Science Vol.14(1) 2015 p.9-13
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Usha, B., Karanth Jyothsna, and Joshi Chandrashekhar G. "Antioxidant, anti-inflammatory, analgesic and anti-proliferating activities of Grewia heterotricha Mast." Biomedicine 40, no. 3 (November 9, 2020): 272–77. http://dx.doi.org/10.51248/.v40i3.5.
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Introduction and Aim: Plants are considered to be novel source of active compounds having pharmacological properties and help in the development of therapeutic agents. Hence, this study was undertaken to evaluate the antioxidant, anti-inflammatory, analgesic and anti-proliferating activity of aqueous and methanolic leaf extracts of Grewia heterotricha Mast.
Materials and Methods: The aqueous and methanolic leaf extracts of the plant were assessed for their in-vitro antioxidant activity by DPPH radical scavenging activity, in-vivo anti-inflammatory activity by carrageenan induced rat paw edema method, in-vivo analgesic activity by acetic acid-induced writhing test and in-vitro anti- proliferating activity by MTT assay.
Results: The methanolic extract had shown very significant DPPH radical scavenging activity with IC50 value 98.95?g/ml than aqueous extract and showed a significant reduction in the paw volume of rats at the concentration of 100 mg/kg body weight indicating potent anti-inflammatory activity compared with the reference standard Diclofenac sodium. Both the extracts showed significant analgesic effect (p<0.001) in acetic acid-induced pain models in a dose dependent manner. The methanolic extract showed higher analgesic activity compared to aqueous extract by inhibiting the pain indicated by a decrease in the number of writhes. In addition, both the extracts showed a decrease in MCF-7 cell viability at the concentration of 550µg/ml. Compared to the aqueous extract, MEGH has shown more cytotoxic effect on the cancer cell lines.
Conclusion: The results suggest that both aqueous and methanolic extracts of Grewia heterotricha Mast. leaves possess potent antioxidant, analgesic, anti-inflammatory and anti-proliferating properties, which supports the use of the plant in traditional medicine. Further investigation is required to illuminate on its active compounds.
Keywords: Analgesic; anti-inflammatory; DPPH; cytotoxic.
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Usha, B., Karanth Jyothsna, and Joshi Chandrashekhar G. "Antioxidant, anti-inflammatory, analgesic and anti-proliferating activities of Grewia heterotricha Mast." Biomedicine 40, no. 3 (November 9, 2020): 272–77. http://dx.doi.org/10.51248/.v40i3.5.
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Introduction and Aim: Plants are considered to be novel source of active compounds having pharmacological properties and help in the development of therapeutic agents. Hence, this study was undertaken to evaluate the antioxidant, anti-inflammatory, analgesic and anti-proliferating activity of aqueous and methanolic leaf extracts of Grewia heterotricha Mast.
Materials and Methods: The aqueous and methanolic leaf extracts of the plant were assessed for their in-vitro antioxidant activity by DPPH radical scavenging activity, in-vivo anti-inflammatory activity by carrageenan induced rat paw edema method, in-vivo analgesic activity by acetic acid-induced writhing test and in-vitro anti- proliferating activity by MTT assay.
Results: The methanolic extract had shown very significant DPPH radical scavenging activity with IC50 value 98.95?g/ml than aqueous extract and showed a significant reduction in the paw volume of rats at the concentration of 100 mg/kg body weight indicating potent anti-inflammatory activity compared with the reference standard Diclofenac sodium. Both the extracts showed significant analgesic effect (p<0.001) in acetic acid-induced pain models in a dose dependent manner. The methanolic extract showed higher analgesic activity compared to aqueous extract by inhibiting the pain indicated by a decrease in the number of writhes. In addition, both the extracts showed a decrease in MCF-7 cell viability at the concentration of 550µg/ml. Compared to the aqueous extract, MEGH has shown more cytotoxic effect on the cancer cell lines.
Conclusion: The results suggest that both aqueous and methanolic extracts of Grewia heterotricha Mast. leaves possess potent antioxidant, analgesic, anti-inflammatory and anti-proliferating properties, which supports the use of the plant in traditional medicine. Further investigation is required to illuminate on its active compounds.
Keywords: Analgesic; anti-inflammatory; DPPH; cytotoxic.
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Hansen, Daiane, Mitsue Haraguchi, and Antonio Alonso. "Pharmaceutical properties of 'sucupira' (Pterodon spp.)." Brazilian Journal of Pharmaceutical Sciences 46, no. 4 (December 2010): 607–16. http://dx.doi.org/10.1590/s1984-82502010000400002.
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The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolites have been investigated in several experimental models in vivo and in vitro. The literature describes flavonoids, triterpene and steroids, while one paper presented studies with proteins isolated from the genus. This review provides an overview of phytochemical and pharmacological research in Pterodon, showing the main chemical compounds studied to date, and focusing on the relationship between these molecules and their biological activity. Furthermore, this study paves the way for more in-depth investigation, isolation and characterization of the molecules of this plant genus.
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Kouchadé, Sabine Aribikè, Arlette Raymonde Adjatin, Aristide Cossi Adomou, Hospice Gbèwonmèdéa Dassou, and Akpovi Akoègninou. "Phytochimiques des plantes médicinales utilisées dans la prise en charge des maladies infantiles au SudBénin." European Scientific Journal, ESJ 13, no. 3 (January 31, 2017): 471. http://dx.doi.org/10.19044/esj.2017.v13n3p471.
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In southern Benin, medicinal plants are used for the health care of children aged 0 to 12 years. The present study aims to highlight some medicinal plants used in southern Benin to treat childhood diseases including malaria, candidiasis, teething disorders, infant colic and diarrhea. The phytochemical screening of the leafy stems of the selected plants revealed the presence of alkaloids, tannins (gallic and catechic), coumarins, anthocyanins and leuco-anthocyans, quinone derivatives, triterpenoids, steroids, saponosides and reducing sugars. These various metabolites possess various therapeutic properties involved in the treatment of the indicated disorders. This would confirm the therapeutic uses reported by the populations surveyed. However, the evaluation of antimalarial, antibacterial, anti-inflammatory and analgesic activities as well as the toxicity test of the aqueous extract of these plants would be necessary.
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Furtado, Ricardo Andrade, Cristiane Teixeira Vilhena Bernardes, Mauro Nogueira da Silva, Karina Furlani Zoccal, Lúcia Helena Faccioli, and Jairo Kenupp Bastos. "Antiedematogenic Evaluation ofCopaifera langsdorffiiLeaves Hydroethanolic Extract and Its Major Compounds." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/913152.
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Inflammatory disorders affect many people worldwide, and medicinal plants are used to ameliorate these health problems. This paper reports the antiedematogenic and analgesic evaluation ofCopaifera langsdorffiiDesf. leaves hydroethanolic extract (Cop) and two of its isolated compounds: quercetin-3-O-α-L-rhamnopyranosyl (quercitrin) and kaempferol-3-O-α-L-rhamnopyranosyl (afzelin). For that, the following experimental protocols were undertaken locomotor performance, writhing induced by acetic acid, antinociceptivity induced by formalin, hot plate latency, paw oedema induced by carrageenan and dextran, and cell migration induced by lipopolysaccharide (LPS), as well as the measurement of nitric oxide (NO), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 10 (IL-10) in macrophages. Neither the extract nor the isolated compounds displayed analgesic activity. The obtained results showed thatC. langsdorffiiextract possesses antiedematogenic properties acting on peripheral sites, whereas quercitrin and afzelin are not involved. Moreover, these properties are not associated with cell migration inhibition, TNF-α, IL-6, or IL-10 regulation.
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Borse, Manali, Shubham Bagade, Atul Bendale, Laxmikant Borse, and Anil Jadhav. "Pharmacoepidemiology of yellow trumpet flower." IP International Journal of Comprehensive and Advanced Pharmacology 7, no. 1 (March 15, 2022): 5–11. http://dx.doi.org/10.18231/j.ijcaap.2022.002.
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Because synthetic pharmaceuticals may produce various side effects and unfavorable consequences, the use of natural plants in therapy is currently more common than synthetic goods. Tecoma stans is a plant found in most tropical countries. This plant belongs to the Bignoniaceae family and is already used in ancient medicine in various countries such as India and Pakistan. This plant has a large number of active chemical ingredients and has pharmacological effects. Many researchers have explored pharmacological screening, and ongoing research is being conducted in that plant. The goal of this study was to update the plant's research collections for pharmacological screening. The review focuses on several researches, such as pharmacognostical studies and in-vitro and in-vivo screening of numorous Tecoma stans components. The various parts of the plants were concluded to have various pharmacological actions such as anti-inflammatory, analgesic, anticancer cardioprotective effect, genotoxic, cytotoxicity, wound healing, antihyperglycemic, protect CNS, gastric ulcer healing, antiproliferative, antioxidant, anti-microbial, haemolytic activity, anti-lipoxygenase, and acetyl-cholinesterase inhibitory activities. This review was then used to guide future study on this plant. A member of the trumpet vine family, Tecoma stans, has been documented for a variety of pharmacological properties. The current research focuses on the neuropharmacological activities of several Tecoma stans extracts. The CNS depressive action was addressed first, followed by the analgesic activity, and then the impact of various extracts on Albino mice was examined.
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Karn, Abhishek, Md Quasim, El Bethel Hmar, Sujata Paul, and Hemanta Sharma. "An updated review of Rubus ellipticus (an edible shrub), its bioactive constituents and functional properties." Sciences of Phytochemistry 1, no. 2 (November 22, 2022): 22–33. http://dx.doi.org/10.58920/sciphy01020022.
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The vast majority of people continue to view medicinal plants as a low-cost source of medications and treatments. Numerous trees, herbs, plants, and shrubs have been used as remedies for various ailments since the dawn of time. Rubus ellipticus Smith, a weedy wild raspberry that flourishes in damp woods at high elevations, particularly those in the Himalayas and the Nilgiris area, is one of the important ethnomedicinal plants in the genus Rubus. Traditional Tibetan medicine places a great deal of importance on the plant R. ellipticus. Because of the abundance and diversity of phenolics and flavonoids in fruits or berries, which have a high concentration of both, they are generally regarded as inherently healthful foods. The roots and leaves, as well as the fruit, have traditionally been used as therapeutic agents for several illnesses including colic pain, gastrointestinal discomfort, wound healing, diarrhea, antifertility, antibacterial, analgesic, epilepsy, and others. The objective of the current review is to concentrate on the pharmacological characteristics, nutrition profile, phytoconstituents, and folkloric therapeutic applications of R. ellipticus, therefore achieving the review's overall subject.
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Tundis, Rosa, and Monica Loizzo. "A Review of the Traditional Uses, Phytochemistry and Biological Activities of the Genus Santolina." Planta Medica 84, no. 09/10 (March 8, 2018): 627–37. http://dx.doi.org/10.1055/a-0585-6153.
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AbstractThe genus Santolina is a taxonomically complex group of plant species widely distributed in the Mediterranean flora and used in traditional medicine since ancient times for their biological properties, including antimicrobial, anti-inflammatory, antispasmodic, digestive, and analgesic activities. Phytochemical investigations of Santolina species have revealed the presence of terpenoids as the main bioactive constituents of the genus. Coumarins and flavonoids were also identified. This review deals, for the first time, with information on the traditional uses, chemical profile, and biological properties of plants of the genus Santolina in order to provide input for future research prospects.
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Fortunato, Renée Hersilia, and María Jimena Nores. "“Cow’s Hoof” (Bauhinia L., Leguminosae): A Review on Pharmacological Properties of Austral South American Species." Plants 12, no. 1 (December 21, 2022): 31. http://dx.doi.org/10.3390/plants12010031.
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The genus Bauhinia s.l. (Leguminosae), known as cow’s hoof, unha de boi or pata de vaca, has been used in traditional medicine worldwide. The aim of the present review is to summarize the studies published on the biological activity of the main native medicinal species reported in austral South America. Of the 14 species present in the region, 10 are consumed as leaf infusions to regulate glucose and lipid metabolism, as well as used for their anti-inflammatory and analgesic effects and to treat various diseases. Pharmacological properties have been recorded in seven species. Antioxidant, anticoagulant, antihypertensive, diuretic, antimicrobial and antitumor properties have been reported in B. forficata. Together with B. holophylla, they are important for their antidiabetic properties, since several studies indicate their effectiveness as a hypoglycemic agent. B. bauhinioides is distinguished for its anti-inflammatory and antithrombotic activities and S. microstachya for its analgesic properties. Anti-ulcer and wound healing activities recorded in B. holophylla and B. ungulata, respectively, are of particular interest. Most of the species possess antitumor activity. The antioxidant capacity of flavonoids and other bioactive compounds make these plants good candidates to assist or treat various alterations related with oxidative stress, such as diabetic complications. Thus, these species constitute promising targets for new bioactive substance research and phytotherapy.
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Jancy, Mary E., and L. Inbathamizh. "Phytochemistry and Pharmacology of Five Traditionally Valuable Herbal Plants: A Review." Research Journal of Biotechnology 17, no. 3 (February 25, 2022): 141–72. http://dx.doi.org/10.25303/1703rjbt141172.
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Herbal plants are used by traditional medical practitioners for the treatment of various diseases. The present review summarizes information about the phytochemistry, biological properties, traditional and medicinal uses of five herbal plants: Plectranthus amboinicus (Indian Borage), Ocimum tenuiflorum (Holy Basil), Mentha piperita (Peppermint), Trigonella foenum-graecum (Fenugreek) and Acalypha indica (Indian Acalypha). The therapeutic uses of plants are considered inexpensive and efficient due to their ease of availability and wide range of biological activities. These herbs are used in medicine for the treatment of various disorders such as asthma, flu, eczema and cardiovascular disorders. They possess medicinal properties and are pharmacologically beneficial through their antioxidant, antimicrobial, antibacterial, antiviral, antifungal, anti-inflammatory, antidiabetic, anticancer, analgesic, antimalarial, antibiofilm, antidiuretic, wound healing activity, skincare, hepatoprotective and hypolipidemic activities. This is due to the presence of various secondary metabolites such as flavonoids, terpenoids, glycosides, phenols, alkaloids, tannins and steroids which have been identified through various spectroscopic methods. The different parts of these herbs have been used to prepare medicines. Due to the presence of various important phytochemicals, they are used in food, nutrition and medicine without side effects. These further find applications in drug discovery, novel drug development, nanodiagnostics and nanotherapy.
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Andrade, Milene Aparecida, Mariana Aparecida Braga, Pedro Henrique Souza Cesar, Marcus Vinicius Cardoso Trento, Mariana Araújo Espósito, Lucilene Fernandes Silva, and Silvana Marcussi. "Anticancer Properties of Essential Oils: An Overview." Current Cancer Drug Targets 18, no. 10 (November 13, 2018): 957–66. http://dx.doi.org/10.2174/1568009618666180102105843.
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Background: Essential oils are complex mixtures of low molecular weight compounds extracted from plants. Their main constituents are terpenes and phenylpropanoids, which are responsible for their biological and pharmaceutical properties, such as insecticidal, parasiticidal, antimicrobial, antioxidant, anti-inflammatory, analgesic, antinociceptive, anticarcinogenic, and antitumor properties. Cancer is a complex genetic disease considered as a serious public health problem worldwide, accounting for more than 8 million deaths annually. Objective: The activities of prevention and treatment of different types of cancer and the medicinal potential of essential oils are addressed in this review. Conclusion: Several studies have demonstrated anti-carcinogenic and antitumor activity for many essential oils obtained from various plant species. They may be used as a substitution to or in addition to conventional anti-cancer therapy. Although many studies report possible mechanisms of action for essential oils compounds, more studies are necessary in order to apply them safely and appropriately in cancer therapy.
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Junior, Armando Jorge, Joyce dos Santos Lencina, Elisangela dos Santos, Jonas da Silva Mota, Roberto Kenji Nakamura Cuman, Elisabete Castelon Konkiewitz, Cândida Aparecida Leite Kassuya, and Saulo Euclides Silva-Filho. "Analgesic and Anti-Inflammatory Properties of Ethanolic Extract of Piper vicosanum Leaves." Pharmaceutics 14, no. 11 (November 14, 2022): 2455. http://dx.doi.org/10.3390/pharmaceutics14112455.
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Nonclinical trials are important to validate the efficacy and safety of medicinal plants. Scientific toxicological studies with Piper vicosanum Yuncker have showed its safety; however, no studies have indicated the analgesic or antiarthritic potential of the ethanolic extract of P. vicosanum leaves (EEPV). The objective of the present work was to evaluate the antiarthritic and antinociceptive effects of EEPV in experimental mouse models. The oral administration of EEPV (100, 300, and 700 mg/kg) and dexamethasone (1 mg/kg) were performed in carrageenan-induced pleurisy, in formalin and acetic-acid-induced nociception, and in zymosan-induced articular inflammation models in Swiss mice. The EEPV (300 mg/kg) was tested in zymosan-articular inflammation, the complete Freund’s adjuvant (CFA) inflammatory model, and in in situ intravitreal microscopy analysis of rolling and adhesion events of leukocytes in the mesenteric microcirculation in mice. EEPV significantly inhibited: (i) nociceptive response at phase 1 and 2, and also in the cold response in the formalin model; (ii) abdominal contortion induced by acetic acid; (iii) mechanical hyperalgesia after 4 and 6 h, knee edema after 6 h, and leukocyte migration in articular inflammation induced by zymosan. All doses of EEPV reduced the leukocyte migration to the inflamed pleural cavity and knee edema 4 h after the zymosan knee injection. The treatment with the EEPV significantly inhibited the CFA-induced edema, mechanical and cold hyperalgesia, and NAG and MPO. The EEPV also significantly inhibited carrageenan-induced leukocyte rolling and adhesion. The present study revealed, for the first time, the antiarthritic and antinociceptive effects of the EEPV.
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Szydełko, Joanna, Magdalena Szydełko, and Anna Boguszewska-Czubara. "Health-promoting properties of compounds derived from Capsicum sp. A review." Herba Polonica 63, no. 1 (March 1, 2017): 67–87. http://dx.doi.org/10.1515/hepo-2017-0006.
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Summary This article presents multidirectional effects of capsaicin and its natural derivatives as well as natural and synthetic analogs in term of their therapeutic properties. Active agents present in various Capsicum genus plants exert analgesic, anti-inflammatory, antibacterial, antioxidant and gastroprotective effects. Furthermore, capsaicin positively influences the metabolism of lipids. Numerous research show that capsaicinoids inhibit proliferation and migration process of cancer cells, what makes them molecules of high interest in oncology. Among broad range of positive activities, we have focused only on those properties that have already found application in medicine or seemed to be the most probably used in the near future. Even if in low or single doses this compound has been reported successful in numerous therapies, the negative consequences of high doses or prolonged administration is also discussed in the review.
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Haïdara, Mahamane, Adama Dénou, Mohamed Haddad, Aïssata Camara, Korotoumou Traoré, Agnès Aubouy, Geneviève Bourdy, and Rokia Sanogo. "Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera." Planta Medica International Open 07, no. 02 (April 23, 2020): e58-e67. http://dx.doi.org/10.1055/a-1142-7072.
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AbstractIn Mali, improved traditional medicines [“Médicaments Traditionnels Améliorés”] are prepared from traditionally used medicinal plants. Recently, the Department of Traditional Medicine has identified Terminalia macroptera Guill. & Perr. (Combretaceae) as a potential candidate for an improved traditional medicine. T. macroptera is a West African medicinal plant used in Mali against various health disorders, with more than 30 different indications mentioned by traditional healers, including hepatitis, gonorrhea, fever, pain relief, and various infectious diseases (Helicobacter pylori-associated diseases). To date, validation of most of the biological activities of has been mainly carried out in vitro, except for antimalarial activities. In this study, the potential anti-inflammatory, antipyretic, analgesic, and hepatoprotective properties of T. macroptera were investigated in different murine models. Administration of T. macroptera ethanolic root and leaf extracts in rats significantly reduced pyrexia, pain, inflammation, and hepatic marker enzymes such as alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase in the different murine models used (p<0.05). A phytochemical screening of T. macroptera revealed the presence of tannins, flavonoids, saponins, anthracene derivatives, sterols, triterpenes, and sugars in both leaf and root extracts as the main phytochemical compounds. This was confirmed by qualitative analysis, liquid chromatography coupled with high-resolution mass spectrometry. T. macroptera extracts demonstrated interesting in vivo antipyretic, analgesic, anti-inflammatory, and hepatoprotective activities. Therefore, T. macroptera should be proposed and further evaluated as a potential improved traditional medicine for the treatment of liver-related disorders and for the relief of pain and fever.
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Niculescu, Olga, Rodica Roxana Constantinescu, and Dana Gurău. "Testing of Medical Sheep Fur with Antimicrobial Properties – Part 1." Leather and Footwear Journal 22, no. 3 (September 30, 2022): 209–16. http://dx.doi.org/10.24264/lfj.22.3.6.
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The medical treatment of patients with rheumatic, joint and muscle diseases can be improved by alternative methods. The essential oils extracted from different plants have certain analgesic, anti-inflammatory, antiseptic, antibacterial, immunostimulating properties, etc. Products have been made based on essential oils with therapeutic properties (mint, cajeput, eucalyptus), which can be used to treat the surface of finished sheep fur for medical purposes. The sheep furs were tanned (without metals) with syntans based on phenolsulfonic acids and aromatic oxysulfones and treated with products based on essential oils with therapeutic properties, to be used to make medical fur articles (lumbar and cervical belts, knee pads, elbow pads, etc.). They can improve rheumatic, muscular and circulatory conditions, complementing the medical treatment of patients suffering from these conditions. The work presents the chemical, physical-mechanical and microbiological characterization of natural furs for medical use.
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Sharma, Ritesh Kumar, Anjana Goel, and A. K. Bhatia. "Lawsonia Inermis Linn: A Plant with Cosmetic and Medical Benefits." International Journal of Applied Sciences and Biotechnology 4, no. 1 (March 31, 2016): 15–20. http://dx.doi.org/10.3126/ijasbt.v4i1.14728.
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Plants play a major role on the earth and human beings depend on plants because of their medicinal properties. About 80% of the world population using plants as a medicinal drugs because plants have no side effects and show synergistic effect unlike modern medicine. In the present study, review and authentication of the various aspects of the plant Lawsonia inermis was carried out. This plant is mainly present in subtropical and tropical areas and is used in all over the world. The common name of L. inermis is Henna and Mehndi. It has been used for over 9000 years for their cosmetic values as a dye. Traditionally, in Asian countries like India and Pakistan, plant leaves are applied to hands, hairs and feet. Morphologically the plant is a small tree or shrub. L. inermis is cultivated for roots, flowers, stem bark and seeds for their medicinal uses. Proteins, carbohydrates and fatty acid are primary metabolites along with secondary metabolite such as tannins, quinines, terpenoids, coumarins etc which are present in L. inermis plant. Phytochemical constituents of L. inermis are responsible for its analgesic, anti-inflammatory, hepatoprotective and hypoglycaemic properties. The plant has also been reported for antibacterial, antifungal, immunostimulatory, antioxidant and cytotoxic activity. Presence of these properties in L. inermis plant develops it as medicine against various pathogenic organism and diseases. This review gives a wide view on the phytochemistry, pharmacological properties and traditional uses of the plant.Int J Appl Sci Biotechnol, Vol 4(1): 15-20
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Velázquez, Francisco, Ricardo Manríquez, Leticia Maya, Lucia Barrientos, and Fernando López-Dellamary. "Phenacetin Isolated from Bursera grandifolia, a Herbal Remedy with Antipyretic Properties." Natural Product Communications 4, no. 11 (November 2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401124.
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Bursera grandifolia and other related species have been used in traditional herbal medicine in Mexico and other Latin American countries for their analgesic, antipyretic and anti-inflammatory properties. From the chloroform extract of leaves of B. grandifolia, a substance was isolated and identified as phenacetin, a well known compound with widely tested analgesic and antipyretic properties. The structural identity of the compound was elucidated on the basis of chemical and spectroscopic evidence and by comparison with an authentic sample.
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Sarwar, Wajid. "Pharmacological and phytochemical studies on Acacia modesta Wall; A review." Journal of Phytopharmacology 5, no. 4 (August 30, 2016): 160–66. http://dx.doi.org/10.31254/phyto.2016.5408.
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The use of plants with therapeutic properties is as ancient as human civilization. Acacia modesta belongs to family Fabaceae and is a deciduous tree which has medium or small size. Traditionally, it has been used to treat leprosy, wounds, dysentery, venereal diseases, cough, body weakness, bacterial infections and backache. Many pharmacological activities have been reported viz. antibacterial, antifungal, anti-hyperglycemic, analgesic, anti-inflammatory, anti-platelet, anti-termite, antioxidant, brine shrimp cytotoxicity, haemagglutination, insecticidal, phytotoxic and spasmolytic. While various flavonoids, terpenoids, alkaloids, tannins, non-protein amino acids, fixed oils and cyclitols have been isolated from this plant. This review is an attempt to provide adequate information on ethno-medicinal uses, general morphology, pharmacological and phytochemical properties of the plant.
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Sai Prasanna, K., G. Jyothi Reddy, M. Kiran, and K. Thyaga Raju. "Biological Activities and Phytochemical Constituents of Trailing Daisy Trilobata: A Review." Journal of Drug Delivery and Therapeutics 9, no. 4-s (October 1, 2019): 888–92. http://dx.doi.org/10.22270/jddt.v9i4-s.3578.
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The traditional system of medicinal plants have been found to possess significant anti-inflammatory, antibacterial, anti-fungal, anti-diabetic, analgesic properties etc. Plant-derived drugs are used to cure mental illness, skin diseases, tuberculosis, diabetes, jaundice, hypertension, and cancer. Wedelia Trilobata belongs to family Asteraceae. Leaf, stem, and flower of Wedelia trilobata show anti-microbial, anti-oxidant and anti-inflammatory activity, analgesic activity. Phytochemical screening of the extract has been reported to show the presence of tannins, cardiac glycosides, flavonoids, terpenoids, phenols, saponins, and coumarins. Wedelia Trilobata is also used in reproductive problems, amenorrhea, chest cold, dry cough, and fever. The present review aims to the study was phytoconstituents, biological and pharmacological activities of Wedelia trilobata. This study suggested a possible use of Wedelia trilobata as a source of natural medicines as an anti-inflammatory, anti-oxidant, anti-microbial, hepatoprotective, antidiabetic agents.
Keywords: Wedelia Trilobata, Trialing daisy trilobata, Complaya trilobata(L), Sphagneticola Trilobata, pharmacological review.
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Zagoto, Mayara, Gabriel Fernando Esteves Cardia, Edvalkia Magna Teobaldo da Rocha, Kathia Socorro Mathias Mourão, Vanderly Janeiro, Roberto Kenji Nakamura Cuman, Adriana Aparecida Pinto, Robinson Luiz Contiero, and Paulo Sérgio Lourenço de Freitas. "Biological activities of basil essential oil: a review of the current evidence." Research, Society and Development 10, no. 12 (September 24, 2021): e363101220409. http://dx.doi.org/10.33448/rsd-v10i12.20409.
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Currently, natural products are being used as a therapeutic alternative in the treatment and prevention of several diseases due to their low toxicity and relevant pharmacological potential. Thus, we can highlight basil (Ocimum basilicum L), one of the most used aromatic plants worldwide. Therefore, we provide some current evidence and insight into the potential therapeutic effect of basil essential oil to expand the available knowledge. A narrative review was carried out by searching electronic databases, providing a comprehensive analysis of the literature, where it was possible to identify existing problems and gaps to facilitate future research on basil essential oil. The available literature on basil essential oil presents us with several important pharmacological activities, such as: antioxidant, antiviral, antimicrobial, analgesic, anti-inflammatory, and analgesic and diuretic properties, among others. However, further research must be carried out to increase knowledge about this plant with enormous potential and determine its effectiveness and use in clinical conditions.
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Ofeimun, Josephine Omose, Happy A. Aghulor, and Zuleikha A. M. Nworgu. "Phytochemical screening and analgesic effect, in mice, of the methanolic leaf extract of Manniophyton fulvum Mull.-Arg. (Euphorbiaceae)." Journal of Pharmacy & Bioresources 19, no. 1 (May 11, 2022): 24–32. http://dx.doi.org/10.4314/jpb.v19i1.4.
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Medicinal plants continue to attract attention as an alternative form of therapy. Phytochemical screening, analgesic properties and probable mechanism/s of action of the methanol leaf extract of Manniophyton fulvum were carried out following claimed folkloric usefulness in this regard. Standard methods were used to screen for classes of phytochemicals. Acetic acid-induced writhing and hot plate tests in albino mice were used to evaluate the peripheral and central analgesic effects using acetylsalicylic acid and morphine respectively as positive controls, while 50% DMSO served as negative control. Elucidation of the possible mechanism/s of action of the extract was carried using phenoxybenzamine, naloxen, ondansetron, atropine and haloperidol. Alkaloids, saponins, carbohydrates, terpenoids, steroids tannins, and flavonoids were detected in the extract. At 100 mg/kg dose, significant (P<0.01) reduction in pain stimuli, compared to the negative control group in both models was observed. Higher doses of extract (200 and 400 mg/kg) did not produce any significant effect. Observed results suggest that the leaf extract of M. fulvum may have an analgesic effect that is centrally and peripherally mediated at a lower dose compared to the high dose. The findings provide possible scientific basis for the ethnomedicinal use of the plant in several pain conditions.
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Silva, Luiz Everson da, and Ana Rafaela Freitas Dotto. "Herbal oils in healthcare: a review." Brazilian Journal of Science 1, no. 4 (April 1, 2022): 18–33. http://dx.doi.org/10.14295/bjs.v1i4.100.
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The herbal medicine market has grown considerably as an alternative currently used for the application of plants in the treatment of various diseases. In this environment, studies on the bioactivity of essential oils and the search for those that have antimicrobial, analgesic, anti-inflammatory, anti-tumor, antioxidant properties and also oils that can inhibit key enzymes are highlighted. However, research on the use of plants in the pharmaceutical industry, chemical composition of native species and possible biological activities are still scarce. Therefore, studies for the knowledge of native species with therapeutic potential gain great relevance. This study carried out a review of the research already done on essential oils from species with potentially promising biological activities for the contribution of the sustainable use of biodiversity and the relevance of their medicinal potential.
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Hashempur, Mohammad Hashem, Fatemeh Khademi, Maryam Rahmanifard, and Mohammad M. Zarshenas. "An Evidence-Based Study on Medicinal Plants for Hemorrhoids in Medieval Persia." Journal of Evidence-Based Complementary & Alternative Medicine 22, no. 4 (January 24, 2017): 969–81. http://dx.doi.org/10.1177/2156587216688597.
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Hemorrhoids is one of the most common gastrointestinal diseases. There are several therapeutic options associated with some complications. Therefore, researchers look for traditional medicines as a potential resource for introduction of new natural drugs. The current study reports an evidence-based review of herbal remedies for hemorrhoids in traditional Persian medicine. A comprehensive survey about hemorrhoids on the most important manuscripts of traditional Persian medicine was done. Then, scientific data banks were searched for possible related properties of each herb in the conventional medicine. We reported some historical aspects of traditional Persian medicine view on classification, examination, and predisposing factors of hemorrhoids. In addition, we have reported 105 medicinal plants belonging to 51 families. More than half of the reported herbs exhibited anti-inflammatory and analgesic effects. Although lack of human studies regarding the mentioned herbs is noted, positive results from experimental findings can be considered for new drug discovery supported by traditional and medieval experiences.
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Thakur, Shifali, Shailja Choudhary, and Bhawna Walia. "Tulsi - A Review Based Upon Its Ayurvedic and Modern Therapeutic Uses." International Journal of Research and Review 8, no. 5 (May 21, 2021): 263–72. http://dx.doi.org/10.52403/ijrr.20210534.
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Herbal plants are considered as the most significant source of medicines. These herbal plants are in practice from ancient times. Traditionally, all the parts of the plant are used for curing various diseases. One of the most important herbal plants is the Ocimum sanctum also called tulsi. This plant is considered a sacred plant in Indian culture and used for holy purposes as well. The name Tulsi comes from Sanskrit word which means "the incomparable one". Tulsi plant is not only used in ayurvedic medicines but also used in other medicinal systems in Greek, Roman and Unani. Apart from this, the Tulsi plant possesses different therapeutical properties due to the presence of several phytochemical constituents in its roots, stem, fruit, and leaves due to the presence of eugenol, vallinin, gallic acid, palmitic acid, oleic acid, linoleic acid, and many more. These phytochemicals are extracted from the plant and used to cure various types of diseases. Tulsi is reported to have properties like anti-ulcer, anti-oxidant, anti-inflammatory, anti-cancer, antidiabetic, anti-arthritic, analgesic, antistress, anti-asthmatic, antifertility, immunomodulatory, and neuroprotective activity. Keywords: Ocimum sanctum, phytochemicals, Eugenol, Tulsi, Ayurveda.
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Das, Gitishree, Han-Seung Shin, Sanjoy Singh Ningthoujam, Anupam Das Talukdar, Hrishikesh Upadhyaya, Rosa Tundis, Swagat Kumar Das, and Jayanta Kumar Patra. "Systematics, Phytochemistry, Biological Activities and Health Promoting Effects of the Plants from the Subfamily Bombacoideae (Family Malvaceae)." Plants 10, no. 4 (March 29, 2021): 651. http://dx.doi.org/10.3390/plants10040651.
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Plants belonging to the subfamily Bombacoideae (family Malvaceae) consist of about 304 species, many of them having high economical and medicinal properties. In the past, this plant group was put under Bombacaceae; however, modern molecular and phytochemical findings supported the group as a subfamily of Malvaceae. A detailed search on the number of publications related to the Bombacoideae subfamily was carried out in databases like PubMed and Science Direct using various keywords. Most of the plants in the group are perennial tall trees usually with swollen tree trunks, brightly colored flowers, and large branches. Various plant parts ranging from leaves to seeds to stems of several species are also used as food and fibers in many countries. Members of Bombacoides are used as ornamentals and economic utilities, various plants are used in traditional medication systems for their anti-inflammatory, astringent, stimulant, antipyretic, microbial, analgesic, and diuretic effects. Several phytochemicals, both polar and non-polar compounds, have been detected in this plant group supporting evidence of their medicinal and nutritional uses. The present review provides comprehensive taxonomic, ethno-pharmacological, economic, food and phytochemical properties of the subfamily Bombacoideae.
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Silva, Raí Emanuel da, Fábio de Oliveira Silva Ribeiro, Gisele Santos de Araújo, Bruno Iles, Otília Deusdênia Loiola Pessoa, Alyne Rodrigues de Araújo, and Maria José dos Santos Soares. "Biological properties of Oncocalyxone A: a review." Research, Society and Development 10, no. 4 (April 22, 2021): e57810414343. http://dx.doi.org/10.33448/rsd-v10i4.14343.
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Quinones are a classic example of molecules isolated from natural products. These compounds are secondary metabolites produced by plants, fungi, bacteria, and insects and correspond to an interesting chemical class ubiquitously found in nature. The [rel-8α-Hydroxy-5-hydroxymethyl-2-methoxy-8α, β-methyl-7, 8, 8a, 9-tetahydro-1, 4-anthracenedione] [oncocalyxone A, onco-A] is a benzoquinone of dark red color isolated from the ethanolic extract of the species Cordia oncocalyx (Auxemma oncocalyx Allem). In this review, we aimed to investigate the main biological activities described for oncocalyxone A, as well as its isolation and characterization processes. For this review, the following descriptors were employed in multiple databases: medicinal plants, quinones, Auxemma oncocalyx, Cordia oncocalyx, biological activity. Besides, experimental papers published in international journals and with full text available were used as inclusion criteria. The biological activity profiles found for onco-A according to the literature were: antiproliferative/cytotoxic effects against SW1573 (alveolar cell carcinoma) and CCD922 (normal skin fibroblasts) cell lines; anti-inflammatory and analgesic potential; inhibitory effect on cell growth and DNA reactivity; antiplatelet activity; antitumor potential; anti-glycation agent; beneficial and/or toxic potential in goats and neuroinhibitory effect; antibacterial and antibiofilm activity. The substance has a broad spectrum of pharmacological applications, most of which are associated with its cytotoxic activity. The work also intends to compile the activities described in the literature, to understand how the molecule acts on the various targets, but, in some cases, more in-depth research is needed to elucidate the mechanisms of action.
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Nisar, Muhammad Farrukh, Mahnoor Khadim, Muhammad Rafiq, Jinyin Chen, Yali Yang, and Chunpeng Craig Wan. "Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review." Oxidative Medicine and Cellular Longevity 2021 (August 3, 2021): 1–14. http://dx.doi.org/10.1155/2021/2497354.
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The biologically active phytochemicals are sourced from edible and medicinally important plants and are important molecules being used for the formulation of thousands of drugs. These phytochemicals have great benefits against many ailments particularly the inflammatory diseases or oxidative stress-mediated chronic diseases. Eugenol (EUG) is a versatile naturally occurring molecule as phenolic monoterpenoid and frequently found in essential oils in a wide range of plant species. EUG bears huge industrial applications particularly in pharmaceutics, dentistry, flavoring of foods, agriculture, and cosmeceutics. It is being focused recently due to its great potential in preventing several chronic conditions. The World Health Organization (WHO) has declared EUG as a nonmutant and generally recognized as safe (GRAS) molecule. The available literature about pharmacological activities of EUG shows remarkable anti-inflammatory, antioxidant, analgesic, and antimicrobial properties and has a significant effect on human health. The current manuscript summarizes the pharmacological characteristics of EUG and its potential health benefits.
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Patience, Dingom Aurelie Taylor, Keugni Armand Brice, Bendegue Emebe Alexandrie Julia, Dzeufiet Djomeni Paul Désiré, Kamtchouing Pierre, and Théophile Dimo. "Analgesic and acute inflammation properties of the aqueous extract of dried leaves of Paullinia Pinnata (Sapindaceae) Linn." International Journal of Phytomedicine 9, no. 3 (September 2, 2017): 490. http://dx.doi.org/10.5138/09750185.2115.
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<p align="left">Inflammation is frequently associated with pain. Plants continue to be major resources for therapeutic compounds against various diseases including inflammation and pain. <em>P</em><em>aullinia Pinnata </em>is used to treat several diseases, including rheumatism and abdominal pain. This study was undertaken to assess the analgesic and anti-inflammatory effects of <em>P</em><em>aullinia Pinnata. </em>The analgesic activity was evaluated by using behaviour pain model in mice. The anti-inflammatory activity was carried out by using carrageenan, dextran, histamine and serotonin induced inflammation in rat. The extract was administered orally at a dose of 200 and 400 mg/kg. The results showed that the extract significantly (P< 0.001) reduced the number of writhing induced by the acid acetic. The aqueous extract reduced significantly (P< 0.001) the paw licking time in formalin model. The effect of the extract (200mg/kg) was significantly (P< 0.001) reduced in the presence of naloxone, during the inflammatory phase. In addition, the extract significantly (P< 0.05) increase latency time at all point time and all doses on nociception induced by hot plate. Concerning inflammation induced by carrageenan and dextran, the extract significantly (P< 0.001) inhibited oedema during the experimental time at the dose of 200 mg/kg. The results suggested that<em> Paullinia pinnata</em> aqueous extract possess analgesic activities which may interfere in both peripheral and central pathway. The anti-inflammatory activities may be mediated by either inhibiting or by blocking the release of vasoactive substances like histamine, serotonin, kinins and prostaglandins. These results justify the traditional use of the plant in the treatment of pain and inflammation.</p>
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Kriplani, Priyanka, Kumar Guarve, and Uttam Singh Baghel. "Novel Herbal Topical Patch Containing Curcumin and Arnica montana for the Treatment of Osteoarthritis." Current Rheumatology Reviews 16, no. 1 (March 5, 2020): 43–60. http://dx.doi.org/10.2174/1573397115666190214164407.
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Background: Osteoarthritis (OA) ranks fifth among all forms of disability affecting 10% of the world population. Current treatments available are associated with multiple side effects and do not slow down the progression of the disease. Moreover, no such effective treatment is available to date in various systems of medicine to treat osteoarthritis. Curcumin and Arnica have shown evident clinical advances in the treatment of osteoarthritis. Objective: The aim of the present study was to design, optimize and characterize novel herbal transdermal patches of curcumin and Arnica montana using factorial design. Methods: A multiple factorial design was employed to investigate the effect of hydroxypropyl methyl cellulose, ethyl cellulose and jojoba oil on elongation and drug release. Transdermal patches were evaluated by FTIR, DSC, FESEM, ex vivo drug permeation, anti osteoarthritic activity and analgesic activity. Results: Independent variables exhibited a significant effect on the physicochemical properties of the prepared formulations. The higher values of drug release and elongation were observed with the higher concentration of hydroxypropyl methylcellulose and jojoba oil. Anti osteoarthritic activity was assessed by complete Freund's adjuvant arthritis model; using rats and analgesic activity by Eddy's hot plate method, using mice. Combination patch exhibited good anti osteoarthritic and analgesic activity as compare to individual drug patches. Conclusion: The design results revealed that the combination patch exhibited good physicochemical, anti osteoarthritic and analgesic activity for the treatment of osteoarthritis in animals. More plants and their combinations should be explored to get reliable, safe and effective formulations that can compete with synthetic drugs.
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Avila-Sosa, Raúl, Andrés Felipe Montero-Rodríguez, Patricia Aguilar-Alonso, Obdulia Vera-López, Martin Lazcano-Hernández, Julio César Morales-Medina, and Addí Rhode Navarro-Cruz. "Antioxidant Properties of Amazonian Fruits: A Mini Review of In Vivo and In Vitro Studies." Oxidative Medicine and Cellular Longevity 2019 (February 17, 2019): 1–11. http://dx.doi.org/10.1155/2019/8204129.
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Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living species; according to some botanists, it would contain about 16-20% of the species that exist today. This region has native fruit trees in which functional properties are reported as antioxidant and antiproliferative characteristics. Amazon plants offer a great therapeutic potential attributed to the content of bioactive phytochemicals. The aim of this mini review is to examine the state of the art of the main bioactive components of the most studied Amazonian plants. Among the main functional compounds reported were phenolic compounds, unsaturated fatty acids, carotenoids, phytosterols, and tocopherols, with flavonoids and carotenoids being the groups of greatest interest. The main beneficial effect reported has been the antioxidant effect, evaluated in most of the fruits investigated; other reported functional properties were antimicrobial, antimutagenic, antigenotoxic, analgesic, immunomodulatory, anticancer, bronchodilator, antiproliferative, and anti-inflammatory, including hypercholesterolemic effects, leishmanicidal activity, induction of apoptosis, protective action against diabetes, gastroprotective activity, and antidepressant effects.
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SHAHRAJABIAN, Mohamad H., Wenli SUN, and Qi CHENG. "Chinese onion, and shallot, originated in Asia, medicinal plants for healthy daily recipes." Notulae Scientia Biologicae 12, no. 2 (June 29, 2020): 197–207. http://dx.doi.org/10.15835/nsb12210725.
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Shallot is an important part of diet of many populations and there is long-held belief in their health enhancing properties. Shallots, like onions, are a member of the Allium family, but their flavor is richer, sweeter, yet more potent. The most important benefits of shallots are high source of antioxidants, improve heart health, cancer prevention, diabetes, anti-inflammatory, antimicrobial, might help fight obesity, and help to prevent or treat allergies. Shallots are a rich source of flavonoid antioxidants such as quercetin and kaempferol. They contain sulfur antioxidant compounds such as diallyl disulfide, diallyl trisulfide, and allyl propyl disulfide. Shallots hole proportionately more concentration of vitamins and minerals than in onions, especially vitamin-A, pyridoxine, folates, thiamin, vitamin-C etc. Chinese onion has very complex nutritional composition and holds the better characteristics for its potential development as a food ingredient, source of antioxidant; it contains secondary metabolites such as flavonoids, particularly flavonols and anthocyanin, phytosterols and saponins. It is also one of the most important medicinal plant in Eastern Asia. It contains many vitamins and minerals and it is rich in sulphur amino acids. Chinese onion was found to possess a panoply of bioactive compounds and numerous pharmacological properties, including antimicrobial, antioxidant, analgesic, anti-inflammatory, anti-diabetic, hypolipidemic, anti-hypertensive and immune-protective effects.
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Imanbayeva, Akzhunis, Gulnara Gassanova, and Ainur Tuyakova. "Results of study of wild medicinal plants of Mangystau region." Bulletin of the Karaganda University. “Biology, medicine, geography Series” 99, no. 3 (October 25, 2020): 43–53. http://dx.doi.org/10.31489/2020bmg3/43-53.
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The study of medicinal plants in the flora of the Mangystau region was the practical interest in assessing the full species composition and prospects for the use of raw materials for the medical and pharmaceutical industries. During 2013–2020, field surveys were carried out to identify the species composition of medicinal plants, their ranking, raw materials and the characteristics of the passage of the main phases of vegetation. The article presents the results of the analysis of the species composition of wild medicinal plants in the natural conditions of Mangystau and their ranking. As a result, the list of medicinal plants amounted to 166 species from 112 genera and 43 families. The predominant number of species is assigned to the families Asteraceae, Chenopodiaceae, Fabaceae, Brassicaceae, Lamiaceae, Apiaceae, Scrophulariaceae,Boraginaceae, Euphorbiaceae and Ranunculaceae. The largest part of medicinal plants is assigned to species used in folk medicine — 144 species; pharmacological properties were found for 50 species; 36 species are included in the Pharmacopoeia of the Republic of Kazakhstan. All plants species were ranked into 10 groups of pharmaceutical-therapeutic activity against different diseases: gastrointestinal tract, oral cavity, kidneys and urinary tract, respiratory tract, antipyretic and anti-inflammatory, cardiovascular system, diabetes mellitus, analgesic and wound healing, skin organs, other diseases. There was performed ranking of medicinal plant species into 4 groups by degree of distribution, area of thickets and possibility of stock collection of vegetal raw materials. A collection calendar has been compiled for 166 species of medicinal plants in the flora of the Mangystau region. The obtained data can be used for organization of systematic harvesting of vegetal raw materials and development of environmental measures.
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Zhang, Benyin, Xiaona Jin, Hengxia Yin, Dejun Zhang, Huakun Zhou, Xiaofeng Zhang, and Lam-Son Phan Tran. "Natural Products, Traditional Uses and Pharmacological Activities of the Genus Biebersteinia (Biebersteiniaceae)." Plants 9, no. 5 (May 7, 2020): 595. http://dx.doi.org/10.3390/plants9050595.
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Medicinal plants have been known as a rich source of natural products (NPs). Due to their diverse chemical structures and remarkable pharmacological activities, NPs are regarded as important repertoires for drug discovery and development. Biebersteinia plant species belong to the Biebersteiniaceae family, and have been used in folk medicines in China and Iran for ages. However, the chemical properties, bioactivities and modes of action of the NPs produced by medicinal Biebersteinia species are poorly understood despite the fact that there are only four known Biebersteinia species worldwide. Here, we reviewed the chemical classifications and diversity of the various NPs found in the four known Biebersteinia species. We found that the major chemical categories in these plants include flavonoids, alkaloids, phenylpropanoids, terpenoids, essential oils and fatty acids. We also discussed the anti-inflammatory, analgesic, antibacterial, antioxidant, antihypertensive and hypoglycemic effects of the four Biebersteinia species. We believe that the present review will facilitate the exploration of traditional uses and pharmacological properties of Biebersteinia species, extraction of the NPs and elucidation of their molecular mechanisms, as well as the development of novel drugs based on the reported properties and mode-of-action.
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Hashim, Saima, Shahida Ayub, Shahida Ayub, Asad Jan, Muhammad Israr, Muhammad Azim Khan, and Muhammad Fawad. "MEDICINAL PROPERTIES, PHYTOCHEMISTRY AND PHARMACOLOGY OF ACACIA MODESTA (Wall.)." JOURNAL OF WEED SCIENCE RESEARCH 28, no. 3 (September 30, 2022): 269–82. http://dx.doi.org/10.28941/pjwsr.v28i3.1058.
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The use of medicinal plants is as ancient as human civilization. Acacia modesta is an important medicinal plant belonging to the family Fabaceae (sub family Mimosaceae). This review aims to provide adequate and latest summary of the traditional usage, phytochemistry, pharmacological and ethnobotanical profile of A. modesta. The important phyto-constituents of A. modesta comprising flavonoids, tannins, alkaloids, fatty acids and polysaccharides (gums) are also highlighted. Pharmacological data on A. modesta shows significant haemagglutination, phytotoxic, insecticidal, anti-diabetic, analgesic, anti-inflammatory, antiplatelet aggregatory, antibacterial and acetyl cholinesterase inhibitory characteristics. Furthermore, A. modesta is also widely used as fodder, fuel wood, timber, household and furniture materials. Ecological importance of the plant is also worth mentioning for its scented and colorful flowers and it serves as one of the desired plant for honey bee raring and honey production. A. modesta is an important, eco-friendly and renewable source of pharmaceuticals with a well-known therapeutic directory. Many researchers have examined its therapeutic potential and common usage through the course of this review.