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Journal articles on the topic 'Analgesic Property'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Jagatheeswari, R., and G. Prasanna. "Evaluation of Analgesic Property of Drynaria quercifolia Rhizome Extract." UTTAR PRADESH JOURNAL OF ZOOLOGY 44, no. 21 (2023): 171–77. http://dx.doi.org/10.56557/upjoz/2023/v44i213684.

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Analgesics are drugs that primarily relieve pain. The main class of painkillers is narcotics, which include additional drugs that are chemically based on morphine molecules. Phytochemicals are a more recent evolution of the term that highlights most of the plant sources of these protective and preventive compounds. Many herbal preparations are prescribed as analgesics in the traditional literature. The search for new analgesics from a large number of medicinal plant resources is intensifying. In this study, we performed a phytochemical screening and analgesic activity of the bark of Drynaria q

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Yahya, N. Z. "EFFECT OF DIFFERENT DOSES OF PUMPKIN SEED OIL AS AN ANTI-INFLAMMATORY AND ANALGESIC ON MICE." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 51, no. 2 (2020): 705–11. http://dx.doi.org/10.36103/ijas.v51i2.998.

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To evaluate the role of anti-inflammatory and analgesicof Iraqi pumpkin seed oil. The oil seed (25-100 mg / kg) were investigated using various experimental models for analgesic and anti-inflammatory benefit. Acetic acid and thermal induced models of pain were used to examine the anti-nociceptive property. Though models of oedema induced by carragenin were used to evaluate anti-inflammation. Results were reported from these studies that the extract prepared from Iraqi pumpkin seeds possess potential anti-inflammatory and analgesic activity when compared with standard drug Diclofenac. Even thou

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Upadhyay, Rajlaxmi, Goutam Siddhartha, Manas Ranjan Upadhyay, and Trupti Rekha Swain. "Study of analgesic property of diacerein in rat." International Journal of Research in Medical Sciences 8, no. 12 (2020): 4316. http://dx.doi.org/10.18203/2320-6012.ijrms20205011.

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Background: Diacerein has been known as an anti-osteoarthritic agent that is usually given along with other analgesic drugs. Still there is no evidence of the analgesic effect of diacerein alone. So this pilot study was undertaken to assess the analgesic property at supra-spinal level by using the tail-flick method.Methods: Diacerein at doses of 50, 100 and 200 mg/kg was given to Albino wistar rats weighing approximately 100-200 grams along with distilled water as placebo. All drugs were given by oral routes and the analgesic effect was evaluated using analgesiometer at baseline, 15 min, 30 mi

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Xiao, Wen-Ping, Yan-Fang Yang, He-Zhen Wu, and Yi-yi Xiong. "Predicting the Mechanism of the Analgesic Property of Yanhusuo Based on Network Pharmacology." Natural Product Communications 14, no. 10 (2019): 1934578X1988307. http://dx.doi.org/10.1177/1934578x19883071.

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Yanhusuo (Corydalis Rhizoma) extracts are widely used for the treatment of pain and inflammation. The effects of Yanhusuo in pain assays were assessed in a few studies. However, there are few studies on its analgesic mechanism. In this paper, network pharmacology was used to explore the analgesic components of Yanhusuo and its analgesic mechanism. The active components of Yanhusuo were screened by TCMSP database, combined with literature data. PharmMapper and GeneCards databases were used for screening the analgesic targets of the components. The protein interaction network diagram was drawn b

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Benites, Julio, Eunices Gutierrez, José López, et al. "Evaluation of Analgesic Activities of Tremetone Derivatives Isolated from the Chilean Altiplano Medicine Parastrephia lepidophylla." Natural Product Communications 7, no. 5 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700517.

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Parastrephia lepidophylla, family Asteraceae, has ancient use in traditional medicine in the region of Tarapacá, Chile. Bioguided fractionation of extracts of this plant was undertaken in the search for compounds with analgesic and antioxidant activity. Two benzofuran derivatives were isolated as the major components of this plant, identified as tremetone 1 and methoxytremetone 6. Remarkably, neither of these showed antioxidant activity, but tremetone 1 exhibited a morphine-like analgesic property. Reduction of this analgesic effect by naloxone suggests a direct effect on opiate receptors as a

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Shruthi, Kumar K. Sharath, and Udyavar Sanat. "Evaluation of Analgesic Property of Ethanolic Extract of Mimosa Pudica Leaves in Swiss Albino Mice." International Journal of Toxicological and Pharmacological Research 12, no. 8 (2022): 225–30. https://doi.org/10.5281/zenodo.11607987.

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<strong>Introduction:</strong> Pain is a localized or generalized, unpleasant sensation that causes a person physical discomfort or mental stress. It is a multi-dimensional experience which involves both the sensory and affective components. Many unpleasant feelings are associated with pain. Analgesia is the absence of pain in response to stimulation that would normally be painful.<em> Mimosa pudica</em> is a source of natural origin which has numerous medical benefits and has a tremendous future potential for research. The present study was undertaken to screen for analgesic pr

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K, Srinivasan, Sivakumar T, Kiruthiga N, Haja Sherief S, Sengottuvelu S, and Duraisami R. "Scientific Approaches in Screening the Analgesic property of Sida Cordata." Journal of University of Shanghai for Science and Technology 23, no. 09 (2021): 1252–62. http://dx.doi.org/10.51201/jusst/21/09623.

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Pain is likely the most common symptomatic complaint in medicine; an understanding of its mechanism is critical to interpret it. Nociception refers to the detection of noxious stimuli by nociceptors, followed by transduction and transmission of the sensory nervous information from the periphery to the brain. Plants have played a unique holistic role for the provision of food, drugs, clothing, shelter, etc. Natural compounds have been extensively explored for new drug discoveries. Indeed, plants have been used as medicines for more than 5000 years, as a source of antibiotics, antineoplastic, an

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8

Das, Smriti Rekha Chanda. "EVALUATION OF ANTIFUNGAL AND ANALGESIC PROPERTY OF STELLARIA MEDIA L." Indian Research Journal of Pharmacy and Science 5, no. 2 (2018): 1456–61. http://dx.doi.org/10.21276/irjps.2018.5.2.8.

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Singh, Rakesh Ranjan, Ashmita Kiran, and Anant Narayan Sinha. "Elucidation of Analgesic Effects of Butorphanol Compared with Morphine: A Prospective Cohort Study." Journal of Biology and Life Science 6, no. 2 (2015): 130. http://dx.doi.org/10.5296/jbls.v6i2.7524.

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Pain is a complex subjective experience comprising of both physical and emotional components. The International Association for the Study of Pain defines pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of damage.”Opioids are essentially important constituent of balanced anaesthesia. They provide adequate analgesia, reduces requirement of inhaled anaesthetic agents, maintain cardiovascular stability and provide adequate post-operative analgesia. Morphine remains the most widely used analgesic and the gold standard a

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Adesipe, Temitayo, Emeka E. J. Iweala, and Abiodun Adebayo. "Evaluation of Analgesic Property of Silver Nanoparticles Synthesized Using <i>Mitracarpus scaber </i>Aqueous Extract." Materials Science Forum 1148 (May 15, 2025): 15–26. https://doi.org/10.4028/p-54u4ps.

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Pain is one of the main causes for which people seek medical attention. Strong, long-lasting, safe analgesics are therefore still needed in the medical industry to treat a wide range of painful disorders, despite recent advancements in pain treatment. The current work is intended to assess the analgesic properties of silver nanoparticles (AgNPs) synthesized using Mitracarpus scaber aqueous extract. Aqueous extraction of Mitracarpus scaber whole plant was done and employed to make and cap AgNPs using 0.1M AgNO3 solution. The produced AgNPs were examined using a variety of methods, such as Fouri

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Bais, G. Abhinav, R. Dinesh Chaple, J. Alpana Asnani, Pratyush Kumar, and Shrikant Mohurle. "In silico studies of pyrano [2, 3-c] pyrazoles derivatives as cyclooxygenase-2 inhibitiors." GSC Biological and Pharmaceutical Sciences 11, no. 1 (2020): 166–70. https://doi.org/10.5281/zenodo.4277110.

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Non-steroidal anti-inflammatory drugs (NSAID’s) have been used widely from several decades for treatment of analgesia and inflammation. The most widely reported side effect of NSAID's is inflammation of gastric regions, ulceration and kidney problems. These side effects are due to non-selective inhibition of cyclooxygenase-2 over cyclooxygenase-1.Therefore we planned to design a potent cyclooxygenase-2 inhibitor using insilico techniques which may be used as anti-inflammatory and analgesics. In this current study we have chosen Pyrano[2,3-c] pyrazoles as the parent moiety along with

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David, Abhinav, Raj Kumar Goel, Prashant Patel, Rahul Kunkolol, and Dattatray H. Nandal. "An experimental study to evaluate and compare the analgesic activity of calcitriol with morphine in albino mice at a tertiary care teaching hospital in Maharashtra, India." International Journal of Research in Medical Sciences 5, no. 1 (2016): 191. http://dx.doi.org/10.18203/2320-6012.ijrms20164547.

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Background: Vitamin D plays vital role in physiological functions in humans through its active form Calcitriol (Vitamin D3). Vitamin D receptors are found in most tissues, attributing to its classic and non-classic actions. Calcitriol exerts important regulatory effects on the molecular pathways involved in inflammation and pain. The present study is done for experimental evaluation of analgesic action of Calcitriol using pain models in albino mice.Methods: In this prospective, experimental study, healthy Swiss albino mice were taken after permission from IAEC. Mice were divided into five grou

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Umeyor, Chukwuebuka, Emmanuel Anaka, Franklin Kenechukwu, Chinazom Agbo, and Anthony Attama. "Development, in vitro and in vivo evaluations of novel lipid drug delivery system of Newbouldia laevis (P. Beauv.)." Nanobiomedicine 3 (January 1, 2016): 184954351667344. http://dx.doi.org/10.1177/1849543516673445.

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Newbouldia laevis (P. Beauv.) is a tropical rainforest plant used in traditional folk medicine for the treatment of malaria, cough, joint pains, stomach ache, oedema and inflammation. The main thrust of this research work was to study the analgesic/anti-nociceptive properties of N. laevis-loaded solid lipid microdispersions. N. laevis leaves were extracted using ethanol, and the extract was formulated into solid lipid microdispersions using lipid matrix comprising a rational blend of Precirol® ATO 5 and Softisan® 154. Characterization of the solid lipid microdispersions include determination o

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Hashimoto, Tatsuya, Yoji Saito, Kazuo Yamada, Nobumasa Hara, Yumiko Kirihara та Mikako Tsuchiya. "Enhancement of Morphine Analgesic Effect with Induction of μ-Opioid Receptor Endocytosis in Rats". Anesthesiology 105, № 3 (2006): 574–80. http://dx.doi.org/10.1097/00000542-200609000-00023.

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Background Morphine can desensitize mu-opioid receptor (MOR), but it does not cause internalization of the receptor after binding. Acute desensitization of MOR impairs the efficiency of signaling, whereas the receptor internalization restores the cell responsiveness to the agonists. Thereby, the property of morphine may limit the analgesic effects of this opiate drug. It has been shown that [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAMGO), a potent MOR agonist inducing the internalization, facilitates morphine to internalize MOR, suggesting that MOR agonists with low relative activity versus endocyto

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Viveka, Shivapura, Dinesha Dinesha, Prasanna Shama, Shivalingegowda Naveen, Neratur Krishnappagowda Lokanath, and Gundibasappa Karikannar Nagaraja. "Design, synthesis, anticonvulsant and analgesic studies of new pyrazole analogues: a Knoevenagel reaction approach." RSC Advances 5, no. 115 (2015): 94786–95. http://dx.doi.org/10.1039/c5ra17391d.

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Idu, MacDonald, Anthonia Omoregbee, and Benjamin Ogunma Gabriel. "Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model." Biology, Medicine, & Natural Product Chemistry 12, no. 1 (2023): 143–50. http://dx.doi.org/10.14421/biomedich.2023.121.143-150.

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This study investigated the biological activities and phytochemical screening of Boswellia dalzielii root ethanol extract. Standard procures were used to evaluate the phytochemicals and antioxidant capacity, antipyretic activity in baker’s yeast-induced pyrexia in mice, analgesic property (hotplate and acetic acid-induced in mice), acute anti–inflammation (carrageenan-induce in rats) and chronic arthritis (formalin–induced in rats) on Boswellia dalzielii root ethanol extract. The phytochemical results revealed the presence of phenol, ascorbic acid, flavonoids, alkaloids, cardiac glycoside, tan

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Rahman, Farida, Pritam Mohan, Jadav Sarma, et al. "Analgesic and anti-inflammatory property of Pongamia pinnata plant." International Journal of Advanced Biochemistry Research 9, no. 4S (2025): 428–34. https://doi.org/10.33545/26174693.2025.v9.i4sf.4189.

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Sun, Wen Xiu, Tun Galag Dong, and Chun Ming Ding. "Crystal Structure Analysis and Antinociceptive Property of Lappaconitine Hydrochloride." Advanced Materials Research 343-344 (September 2011): 1049–52. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.1049.

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An alkaloid compound, lappaconitine Hydrochloride, was synthesized with lappaconitine which was isolated from the root ofAconitum sinomontanum Nakaiin Gansu province in China. The structures were elucidated by IR,NMR, Anal. and X-ray diffraction analysis. Crystal data: C32H47ClN2O9,Mr= 639.17, space group monoclinic, P21; a=10.665 (7) Å, b=12.178 (7) Å and c=12.214 (7) Å; β=91.003 (10)°, Z=2, Dx= 1.338 mg/m-3,F(000)= 684,µ=0.18.00 mm-1, V=1586.1 (16) Å3; R1=0.038,wR2=0.087, Flack parameter x= -0.12 (7). RingA, B, C, D, EandFrespectively present boat, chair, envelope, boat, boat and envelope fo

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Boampong, Johnson Nyarko. "In VivoAntiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts ofHaematostaphis barteriHook F. (Anacardiaceae)." Journal of Parasitology Research 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/872892.

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Malaria is an endemic disease globally and the conundrum of drug resistance has led to the search for newer antimalarial agents. The root extract ofH. barteriwas evaluated for antimalarial, analgesic, and anti-inflammatory properties. The prophylactic effect ofH. barterionP. bergheiwas determined by pretreating mice with aqueous root extract ofH. barteri(30–300 mg/kg), saline, and 1.2 mg/kg sulfadoxine/pyrimethamine for three days followed by 1 × 106P. bergheiinoculation. Parasite density was measured after 72 h. The curative antimalarial property of the extract was assessed by treating mice w

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Vrushali Neve, Jui Darbhe, Vrushali Bhalchim, et al. "Evaluation of Anti-Inflammatory and Analgesic Property of Methanolic Extract of Momordica Dioica in Wistar Rat Model." Journal of Advanced Zoology 44, S5 (2023): 3022–36. http://dx.doi.org/10.17762/jaz.v44is5.2346.

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Background: Since current medications frequently cause potentially serious side effects, countless individuals continued to have pain and inflammation despite the accessibility of treatments. Ancient practitioners have used a variety of herbal remedies with analgesic and anti-inflammatory properties extensively. Momordica Dioica is one of them, but no experimental research has been done in support of this traditional use. Objective: The purpose of the research was to assess the analgesic and anti-inflammatory properties of methanolic Momordica Dioica fruit extracts. Methods: Dryed by air Accor

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Di Giannuario, A., S. Pieretti, C. Galeffi, A. Capasso, and M. Nicoletti. "The Analgesic Property of Hypoxoside, A Glucoside from Hypoxis Obtusa." Pharmacological Research 27 (May 1993): 95–96. http://dx.doi.org/10.1006/phrs.1993.1082.

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Ghizlane, Hajjaj, Bahlouli Aziz, Tajani3 Mouna, Cherrah Yahia, and Zellou Amina. "Chemical Composition and Antinociceptive Effect of Pistacia atlantica desf. Essential Oil from Morocco." Pharmaceutical and Chemical Journal 5, no. 1 (2018): 17–23. https://doi.org/10.5281/zenodo.13890224.

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The chemical composition of crushed fruits and aerial parts essential oil, hydrodistilled from <em>Pistacia atlantica</em> DESF., were studied by gas chromatography-mass spectrometry, a significant difference in their chemical compositions were observed. The analgesic activity was carried out with the essential oil for its peripheral and central antinociceptive potentials on acetic acid-induced writhing and tail immersion test in rodents, respectively. The analgesic activity of <em>Pistacia atlantica</em> DESF. Essential oil was found to be significant (P<0.05) on acetic

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Deepthi, P. "ROLE OF PREOPERATIVE EPIDURAL ANALGESIA IN POSTOPERATIVE OUTCOME OF PATIENTS WITH CHRONIC LIMB ISCHEMIA AND REST PAIN." International Journal of Advanced Research 8, no. 12 (2020): 847–49. http://dx.doi.org/10.21474/ijar01/12223.

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Introduction:Rest pain in patients with chronic limb ischemia is very severe and intolerable one, hence it is often quoted as cry of dying nerves. All these patients require highly effective analgesia for control of pain. Epidural analgesia is known for its effective analgesic property. Its role in post operative period is well documented and known. But its role in preoperative period for these patients is poorly understood. Here we analyze role of preoperative epidural analgesia in postoperative outcome of patients with chronic limb ischemia and rest pain. Material and Methods:It is a prospec

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Dikioye, Emmanuel Peters, Onyebuchi Ezendiokwere Emmanuel, Chinedu Njoku Uche, Friday Ikehide, and Owhonda Wegwu Matthew. "Phytochemical Composition and Analgesic Property of Ethanolic Leaf Extract of Maesobotrya barteri." Journal of Advances in Biology & Biotechnology 13, no. 4 (2017): 1–8. https://doi.org/10.9734/JABB/2017/32994.

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<strong>Aim:</strong> This study was carried out to identify the phytochemical composition of <em>Maesobotrya barteri,</em> and effect on infra-red induced pain in mice. <strong>Methodology:</strong> Twenty albino mice were selected and randomly placed in 5 groups of 4 animals each. Pain was induced by infra-red heat. Group 1 was treated with distilled water, Group 2 received 100 mg/kg bwt of aspirin. Extract doses of 500 mg/kg, 800 mg/kg and 1000 mg/kg bw were given to groups 3, 4 and 5 respectively. The time taken for the animals to flick their tail off the I.R window was noted in seconds an

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Rahman, Mohammad Sharifur, Nushrat Jahan, S. M. Ashikur Rahman, and Mohammad Abdur Rashid. "Analgesic and antidepressant activities of Brassica rapa subspecies chinensis (L.) Hanelt on Swiss-albino mice model." Bangladesh Medical Research Council Bulletin 41, no. 3 (2016): 114–20. http://dx.doi.org/10.3329/bmrcb.v41i3.29886.

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Bangladesh being a subtropical country provides varieties of herbs and vegetables. Brassica is a broad genus available in Bangladesh and it encompasses a lot of nutritive herbs. Among these, Brassica rapa subspecies chinensis (L.) Hanelt (Family-Brassicaceae) is popular in many parts of the world. In the quest of medicinal property, this plant was investigated here for observing analgesic and antidepressant activities in Swiss-albino mice model. The herb was extracted well with methanol and then assayed by acetic acid-induced writhing and tail immersion methods for analgesic action. Besides, t

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Dr., T. Mangilal S.Likitha Shaistha Tabassum Syeda Sana Fatima S.Nikitha. "PREPARATION AND EVALUATION OF TAPENTADOL INSITU GEL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8429–38. https://doi.org/10.5281/zenodo.2652057.

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<em>The aim of the present study is to prepare and evaluate Tapentadol insitu gel.</em><em> In the present study, an attempt was made to prepare topical analgesics gels by hydrogel/ </em><em>Dispersion</em><em> m</em><em>ethod by using polymer Carbopol 940 as a key ingredient which gives pH-induced sol to gel conversion of the formulations. Different formulations were prepared by varying the ratios of carbopol 940 and different grades of Hydroxyl Propyl Methyl Cellulose (HPMC K100, HPMC K4M). These formulations were evaluated for parameters like pH, drug content, viscosity, gel strength, in vi

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Rawat, Himanshu, Anju KP, and Nisha Kumari Ojha. "MEDICINAL PROPERTIES OF GUDUCHI (TINOSPORA CORDIFOLIA): A SYSTEMATIC REVIEW." International Journal of Research in Ayurveda and Pharmacy 13, no. 5 (2022): 143–50. http://dx.doi.org/10.7897/2277-4343.1305143.

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In traditional medicine, Guduchi is considered to have a status of the highest order in natural medicine and Ayurveda. Guduchi is derived from a Sanskrit word called “Amrita” due to its medicinal and therapeutic properties. In vitro and in vivo studies around the world proved the medicinal value of Tinospora cordifolia. Guduchi's medicinal therapeutic effect was identified: antioxidant property, antimicrobial property, anticancer activity, antihepatotoxic effects, anti-inflammatory activities, antistress and memory enhancement, antidiabetic property, anti-osteoporotic effect, analgesic activit

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Islam, Mohammad Ashraful, Saimon Shahriar, Tanveer Hossain, et al. "In vitro Antioxidant and In vivo Analgesic Activities of Citrullus lanatus Rind and Flesh Extract: A Comparison." Bangladesh Pharmaceutical Journal 25, no. 1 (2022): 67–72. http://dx.doi.org/10.3329/bpj.v25i1.57842.

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The present study was carried out to assess and compare the analgesic and antioxidant potential of Citrullus lanatus rind and flesh extract. The methanolic extract of the rind and ethyl acetate extract of the flesh were evaluated for their in vivo analgesic activity through the acetic acid-induced writhing method on Swiss Albino mice. The free radical scavenging activity of the extracts was measured by total phenolic content measurement and the DPPH method. The flesh extract showed higher antioxidant activity than the rind extract in both methods. In case of the evaluation of analgesic activit

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Bulus, Adzu, Ahmed Chindo Ben, David Tarfa Florence, Adeola Salawu Oluwakanyinsola, and John Igoli Ogbaji. "Isolation and analgesic property of lupeol from Diospyros mespiliformis stem bark." Journal of Medicinal Plants Research 9, no. 30 (2015): 813–19. http://dx.doi.org/10.5897/jmpr2015.5877.

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Chitra, M., E. Sukumar, V. Suja, and Shyamala Devi. "Antitumor, Anti-Inflammatory and Analgesic Property of Embelin, a Plant Product." Chemotherapy 40, no. 2 (1994): 109–13. http://dx.doi.org/10.1159/000239181.

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Semwal, Bhupesh Chander, Kalyani D, and Rohit B. "ANALGESIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AERIAL PARTS OF MALVASTRUM COROMANDELIANUM." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (2016): 146. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.12822.

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ABSTRACTObjective: The aim of this study is to explore the antinociceptive property of hydroalcoholic extract of Malvastrum coromandelianum. Pain is anunpleasant sensory and emotional experience associated with actual and potential tissue damage. Various types of pain are seen in humans, somatic,visceral, and neuropathic pain. M. coromandelianum belongs to Malvaceae family. Traditionally, it is used as an emollient, anti-inflammatory, analgesic,and antidysenteric.Methods: The antinociceptive effects of hydroalcoholic extract of M. coromandelianum (HEMC) were evaluated by tail-flick, hot-plate,

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Avoseh, Opeyemi N., Isiaka A. Ogunwande, Gbenga O. Ojenike, and Fanyana M. Mtunzi. "Volatile Composition, Toxicity, Analgesic, and Anti-Inflammatory Activities of Mucuna pruriens." Natural Product Communications 15, no. 7 (2020): 1934578X2093232. http://dx.doi.org/10.1177/1934578x20932326.

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The volatile constituents, toxicity, antinociception, and anti-inflammatory activities of the essential oil obtained from the leaf of Mucuna pruriens utilis collected from Nigeria are reported. The essential oil was analyzed comprehensively utilizing gas chromatography (GC)-flame ionization detector and GC coupled with mass spectrometry (MS) using the HP-5 column. The antinociceptive and anti-inflammatory assays were analyzed by a hot plate, formalin, and carrageenan-induced edema assays, respectively. The essential oil was obtained in a yield of 0.2% (v/w) calculated on a dry weight basis. A

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Aburas, Khaled, Akram Misbah, Hana Fehelbum, and Asmahan Abukhdir. "Analgesic effect by using hot Plat and tail flick test in rats models for aqueuos moringa oleifer extract." Libyan Journal of Medical Research 17, no. 1 (2023): 107–19. http://dx.doi.org/10.54361/ljmr.17-21.

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Introduction Drugs and plants are closely related to each other through the use of traditional medicines that is mainly prepared from plants. Plants are screened for presence of bioactive components responsible for the activity. Various types of plants have been used not only as dietary supplements but also as traditional treatments for many diseases. Moringaoleifera of Moringaceae is a potential source of phytochemical ingredients claimed to have analgesic property. Objective The present study aimed to investigate the analgesic activity of Moringaoleifera extract in albino rats by using taıl

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Rabha, Kushal, Pritam Mohan, Sumitra Debnath, et al. "Formulation and Evaluation of Hydroethanolic and Chloroform Extracts of Zanthoxyllum oxyphyllum for Analgesic and Wound Healing Activities." Advances in Research 26, no. 2 (2025): 33–44. https://doi.org/10.9734/air/2025/v26i21272.

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Zanthoxylum oxyphyllum under the family Rutaceae, commonly known as Mezenga in Assam grow in tropical and temperate regions. Hydroethanolic and chloroform extracts of leaves of the plant were screened for analgesic activity and wound healing property by hot plate test and excision, incision wound model. The acute toxicity study revealed that both the plant extracts were non-toxic and safe for oral dosing. Both the extracts were non-sensitizing to rabbit skin and caused very little or no irritation in intact and damaged skin rabbits treated with single and multiple doses. Irritation scores did

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Aboobacker C P, Shabeel, Shamjith K, Melbin Baby, and Salman Mohammed Kutty C. "A comparative study to assess the efficacy of addition of dexmedetomidine to levobupivacaine in brachial plexus block." Indian Journal of Clinical Anaesthesia 8, no. 2 (2021): 155–60. http://dx.doi.org/10.18231/j.ijca.2021.033.

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Brachial plexus block is one of the best surgical technique for upper limb surgeries. It is a good anesthetic and analgesic agent. Though levobupivacaine has a duration of action of three to eight hours it has an acceptable analgesic property and few other practical constraints. Addition of vasoconstrictors like α-adrenergic agonists, hyaluronidase, neostigmine, opioids have been found to be effective. Dexmedetomidine, an α2 receptor agonist has found to be a better adjuvant to levobupivacaine by few literatures. To assess the effect of levobupivacaine 0.5% alone and with dexmedetomidine 100 μ

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Liu, Yang, Qiang Hu, and Junyi Yang. "Oliceridine for the Management of Acute Postoperative Pain." Annals of Pharmacotherapy 55, no. 10 (2021): 1283–89. http://dx.doi.org/10.1177/1060028020987679.

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Objective To review the pharmacological characteristics, clinical evidence, and place in the management of acute postoperative pain severe enough to require an intravenous opioid. Data Sources A comprehensive literature search was conducted in PubMed (January 2000 to December 1, 2020). Key search terms included oliceridine or acute postoperative pain. Other sources were derived from product labeling and ClinicalTrials.gov. Study Selection and Data Extraction All English-language articles identified from the data sources were reviewed and evaluated. Phase I, II, and III clinical trials were inc

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Wu, Chi-Rei, Wen-Hsin Lin, Yung-Ta Lin, Chi-Luan Wen, Hui Ching, and Li-Wei Lin. "Analgesic and Anti-Inflammatory Property of the Methanol Extract from Ligustrum morrisonense Leaves in Rodents." American Journal of Chinese Medicine 39, no. 02 (2011): 335–48. http://dx.doi.org/10.1142/s0192415x11008865.

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Ligustrum morrisonense Kaneh and Sasaki (abbreviated as LM), an endemic Ligustrum plant in Taiwan, is similar to Ligustrum lucidum, which is usually used for curing hepatic and inflammatory disorders. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of LM by chemical-induced algesia and carrageenan-induced inflammation in rodents. Its triterpenoid contents were measured by using high performance liquid chromatography-photodiode array detector. LM leaf extracts effectively inhibited writhing responses induced by 1% acetic acid and biphasic-licking responses c

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Abdur Rahman, S. M., Tasmia Ahmed, Muhammad Asaduzzaman, Fahad Imtiaz Rahman, and A. K. Azad Chowdhury. "Broad spectrum antimicrobial, anti-inflammatory and peripheral analgesic activities of heteroaryl nitazoxanide analogs." Egyptian Pharmaceutical Journal 23, no. 2 (2024): 348–58. http://dx.doi.org/10.4103/epj.epj_218_23.

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Background The antiparasitic drug nitazoxanide possesses diverse biological activity. However, very few investigation was accomplished with nitazoxanide analogs. Therefore, herein we focused on the screening of bioactivities using some nitazoxanide-like synthesized molecules. Objectives Four heteroaryl nitazoxanide analogs synthesized in our laboratory were investigated for antimicrobial, anti-inflammatory, and analgesic activity. Materials and methods Disc diffusion method was used for assessing antimicrobial potency against several Gram-positive bacteria, Gram-negative bacteria, and fungi. C

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Solomon, Ijioma, Madubuike Kelechi, and Nwosu Chinenyenwa. "Analgesic (Antinociceptive) Property of Moringa oleifera Ethanol Leaf Extract in Albino Rats." Journal of Advances in Biology & Biotechnology 1, no. 1 (2014): 23–29. http://dx.doi.org/10.9734/jabb/2014/11679.

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Peters, Dikioye, Emmanuel Ezendiokwere, Uche Njoku, Ikehide Friday, and Matthew Wegwu. "Phytochemical Composition and Analgesic Property of Ethanolic Leaf Extract of Maesobotrya barteri." Journal of Advances in Biology & Biotechnology 13, no. 4 (2017): 1–8. http://dx.doi.org/10.9734/jabb/2017/32994.

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Shukla, ShashiBharti, Deepak Jain, and Sofiya Verma. "Lack of analgesic property in xanthium strumarium Linn. Fruit′s butanolic extracts." Journal of Pharmaceutical Negative Results 3, no. 1 (2012): 22. http://dx.doi.org/10.4103/0976-9234.99643.

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Katikireddy, Ramamurthy, Ramu Kakkerla, M. P. S. Murali Krishna, Gandamalla Durgaiah, Y. N. Reddy, and Mavurapu Satyanarayana. "Synthesis and Biological Evaluation of (E)-N’-Benzylidene-7-methyl-2-propyl-1H-benzo[d] imidazole-5-carbohydrazides as Antioxidant, Anti-inflammatory and Analgesic agents." Heterocyclic Communications 25, no. 1 (2019): 27–38. http://dx.doi.org/10.1515/hc-2019-0009.

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Abstract(E)-N’-Benzylidene-7-methyl-2-propyl-1H-benzo [d]imidazole-5-carbohydrazides (5a-r) have been synthesized from 7-methyl-2-propyl-1H-benzo[d]imidazole-5-carbohydrazide (3) by condensing with different aromatic aldehydes (4a-r). Title compounds (5a-r) were evaluated for in vitro antioxidant activity and based on their potential for antioxidant property, selected compounds 5d and 5m-p were screened for in vivo anti-inflammatory and analgesic activity. The results indicate that the compound 5o and 5p are effective against anti-inflammatory and analgesic activity. The biological data was fu

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Aby Mathew Jose and Akhila Vinod. "An experimental evaluation of Anti-Inflammatory and Analgesic Activity of Allium Cepa Linn. and Allium Ascalonicum Linn. - A comparative study." Journal of Ayurveda and Integrated Medical Sciences 9, no. 5 (2024): 35–39. http://dx.doi.org/10.21760/jaims.9.5.7.

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Introduction: The drugs possessing Vataghna property are much indicated in classics for managing Shotha and Vedana. Cost-effective, widely available, and potent drugs should be encouraged over costly ones. The present study was undertaken based on this, focusing on the bulb of Allium cepa Linn. & Allium ascalonicum Linn. to evaluate the anti-inflammatory and analgesic activities employing carrageenan induced paw oedema in wistar albino rats and hotplate tests in mice, respectively. Materials and Methods: Fresh juice of Allium cepa Linn. and Allium ascaloncum Linn. was given to rats and mic

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Yadav, Nisha Kumari, Tripti Shukla, Neeraj Upmanyu, Sharad Prakash Pandey, Mohammad Azaz Khan, and Deepak Kumar Jain. "Concise review: Therapeutic potential of flupirtine maleate." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 467–71. http://dx.doi.org/10.22270/jddt.v9i1-s.2350.

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Flupirtine is a non-opioid analgesic without antipyretic or antiphlogistic properties. Flupirtine is a centrally acting analgesic but the analgesic action of flupirtine does not depend on any central opioid effect. The fact behind this statement is that the pain-relieving property of flupirtine is not reduced by the opioid antagonistic drug naloxone. Flupirtine has been reported for its neuro-protective properties and possess a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. Flupertine is transformed into two primary derivatives, 4-fluoro-hippuric

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Ul Hoque, Md Sajjad, Mohammed Sohel Chowdhury, Arkajyoti Paul, et al. "In vivo analgesic effect of different extracts of Hopea odorata leaves in mice and in silico molecular docking and ADME/T property analysis of some isolated compounds from this plant." Journal of Basic and Clinical Physiology and Pharmacology 30, no. 1 (2018): 121–30. http://dx.doi.org/10.1515/jbcpp-2018-0046.

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AbstractBackgroundThe current study evaluates the analgesic effect of different extracts ofHopea odorataleaves in mice followed by molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADME/T) analysis of isolated compounds derived from the plant with the COX-1 enzyme.MethodsIn the present study, the dried leaves ofH. odoratawere subjected to extraction using methanol, ethanol, and water.In vivoanalgesic activity was evaluated by using the acetic acid-induced writhing test and formalin-induced paw licking test, andin silicomolecular docking and ADME/T study were

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Santhosh, K. H., H. Manjunatha, B. S. Ravindranath, S. R. Swapna, and M. Deepthi. "EVALUATION OF ANALGESIC PROPERTY OF BIOSYNTHESIZED AGNPS USING LEAF METHANOL EXTRACT OF Brugmansia suaveolens." RASAYAN Journal of Chemistry 17, no. 01 (2024): 138–45. http://dx.doi.org/10.31788/rjc.2024.1718724.

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The plant Brugmansia suaveolens (Bercht. & Presl) belongs to the family Solanaceae and is endemic to the Malnad region (Shimoga) of the Western Ghats. Traditionally leaf extract has been applied externally to treat cut wounds, pain-killer swellings, scalds, inflammations, skin rashes, and hemorrhoids. The objective is to synthesize silver nanoparticles (AgNPs) conjugated Leaf methanol extract of B. suaveolens analyzed and characterized based on multiple (X-ray diffraction (XRD); Scanning electron microscopy (SEM); Fourier transform infrared (FTIR) spectroscopy and ultraviolet–visible (UV–V

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Cabrera López, Antony, Asela Garnica Sánchez, Leobardo Reyes Velasco, Gabriel Sánchez Cruz, and Héctor Ulises Bernardino Hernández. "Efecto analgésico de dos formas farmacéuticas tópicas con extracto de Lactuca sativa." Tequio 2, no. 6 (2019): 17–23. http://dx.doi.org/10.53331/teq.v2i6.5402.

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Pain is a public health problem. Its pharmacological treatment is performed through conventional synthetic drugs (non-opioid analgesics and opioids), which have negative effects at the liver, gastric and renal levels. Less aggressive alternatives which use different plant species are under study. Lactuca sativa is a plant used as a popular remedy to treat insomnia, stomach problems, pain and inflammation. Its extracts have been evaluated pharmacologically as anticonvulsant, sedative-hypnotics and antioxidants, mainly in animal models. A study was carried out to evaluate the analgesic property

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Patel, Malaya Kumar, Mahendra Ekka, Sheela Ekka, Harekrishna Dalai, and Pragyan S. P. Pujahari. "A COMPARATIVE STUDY OF PREEMPTIVE ANALGESIC PROPERTY OF INTRAVENOUS PARACETAMOL AND DICLOFENAC SODIUM." Journal of Evidence Based Medicine and Healthcare 5, no. 6 (2018): 477–82. http://dx.doi.org/10.18410/jebmh/2018/97.

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Ishitsuka, Yoichi, Yuki Kondo, and Daisuke Kadowaki. "Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?" Biological and Pharmaceutical Bulletin 43, no. 2 (2020): 195–206. http://dx.doi.org/10.1248/bpb.b19-00722.

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Chaiprateep, Em-on, and Chalermsak Thavornwat. "Optimization of Clinacanthus nutans Biodegradable Analgesic Patch." Natural Product Communications 13, no. 12 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301201.

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This paper aims to analyze and perfect the C. nutans-based biodegradable patch for analgesic employing a design of experiment (DoE) by Minitab version 18 program. Fifty-four full factorial design formulation were used to determine three factors and levels. They are made up of various concentration of 2%, 4%, and 6% of sodium alginate (ALG-Na) and Aloe vera juice. The sodium alginate (ALG-Na) and Aloe vera juice play the role of natural film former and terpenes act as permeation enhancers (eugenol, anethole, limonene). The Physicochemical characteristics include weight variation, thickness, sur

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