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Dissertations / Theses on the topic 'Analgetic activity'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Liu, Bichong. "The basis of analgesic activity of four Chinese herbs." Thesis, Liverpool John Moores University, 1999. http://researchonline.ljmu.ac.uk/5034/.

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This study investigate the effects of four Chinese herbs for their potential therapeutic use as analgesics. It involved screening for inhibitors of enkephalin-hydrolysing enzymes, especially selective NEP inhibitors, mixed NEP/APN inhibitors and mixed NEP/ACE inhibitors. NEP was the key enzyme in the screening systems. Four Chinese herbs Yan (Corydalis yanhusuo T. Wang); Gou (Nauclea sinensis Oliv. ); Qiang (Notopterygium incisum Ting ex H.T. Chang); and Chuan (Ligusticum chuanxiong Hort.) were tested for their inhibitory effects on NEP activity measured in a rat kidney extract. Aqueous extrac

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2

Amaral, Patrícia de Aguiar. "Síntese de δ-valerolactones e avaliação biológica : citotóxica, analgésica e antiinflamatória". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/14883.

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Le travail présenté dans ce manuscrit est consacré à la synthèse et à l'évaluation pharmacologique de quelques δ-valérolactones. Une première séquence réactionnelle a permis d'accéder aux analogues synthétiques des kavalactones avec de bons rendements en développant notamment des réactions de couplage par activation aux micro-ondes. Diverses modulations ont ensuite été réalisées par des couplages de type Heck, Suzuki et Sonogashira. Parallèlement une deuxième séquence réactionnelle a été mise au point au départ d'alcools allyliques en utilisant une réaction tandem isomérisation-aldolisation av

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3

Corder, Gregory F. "INJURY ESTABLISHES CONSTITUTIVE µ-OPIOID RECEPTOR ACTIVITY LEADING TO LASTING ENDOGENOUS ANALGESIA AND DEPENDENCE." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/10.

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Injury causes increased pain sensation in humans and animals but the mechanisms underlying the emergence of persistent pathological pain states, which arise in the absence of on-going physical damage, are unclear. Therefore, elucidating the physiological regulation of such intractable pain is of exceptional biomedical importance. It is well known that endogenous activation of µ-opioid receptors (MORs) provides relief from acute pain but the consequences of prolonged endogenous opioidergic signaling have not been considered. Here we test the hypothesis that the intrinsic mechanisms of MOR signa

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4

Mills, Clive. "Saponins from Barringtonia acutangula and Inhibition of Protein Phosphatase Activity by Acacia Extracts." Thesis, Griffith University, 2000. http://hdl.handle.net/10072/366502.

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The work presented in this thesis is divided into two projects, the isolation and characterisation of analgesic activity in the bark of Barringtonia acutangula and the initiation of an assay for protein phosphatase activity which could be used as a high throughput screen. Analgesic activity had been reported in the bark of Barringtonia acutangula, a tree which grows across northern Australia, by aboriginal people living in the Kimberley district of NorthWwestern Australia. B. acutangula is one of four species of Barringtonia which grow in Australia and one of many which grow in tropical region

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5

Serra, Miguel Ângelo Serafim. "Impacto da dor causado por doenças podais sobre a atividade e produção de vacas leiteiras." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/18946.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>As doenças e lesões podais são comuns em explorações leiteiras intensivas. A claudicação resultante destas é uma expressão de dor e de desconforto tendo inúmeros impactos negativos ao nível do bem-estar, produtividade e interação social. Tradicionalmente, a claudicação é detetada pela avaliação visual da locomoção apesar da subjetividade e dificuldade por parte dos produtores em avaliar a sua gravidade. A analgesia surge como complemento ao tratamento tradicional à base do corte terapêutico para controlo da dor e modulação da hiperal

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6

Mestre, Christine. "Influence de la specificite monoaminergique des antidepresseurs sur leur activite antinociceptive : etude du site d'action et des mecanismes neurobiochimiques impliques a l'aide de modeles experimentaux de douleur chronique." Clermont-Ferrand 1, 1995. http://www.theses.fr/1995CLF1MM02.

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7

Buchwalder, Theres. "Effect of familiarity, group size, and floor space availability on agonistic behaviour in fattening turkeys (Meleagris gallopavo) and effect of an analgesic on their activity behaviour." [S.l.] : [s.n.], 2004. http://www.zb.unibe.ch/download/eldiss/04buchwalder_t.pdf.

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8

Lafrance, Mylène. "Relation structure-activité, distribution et fonctions des récepteurs couplés aux protéines G : NTS2 et APJ." Thèse, Université de Sherbrooke, 2014. http://hdl.handle.net/11143/5396.

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Les récepteurs couplés aux protéines G (RCPG) de classe A sont les cibles de plus de 25% des médicaments sur le marché et nombreux sont ceux impliqués dans le traitement de la douleur. Les enjeux dans les traitements de la douleur chronique est énorme puisque nombreux sont ceux qui ne répondent pas à la médication usuelle. La recherche de nouvelles avenues thérapeutiques est indispensable afin d’aider les patients dont le soulagement est limité. Le récepteur de la neurotensine de type 2 (NTS2) et le récepteur APJ de l’apéline sont deux RCPG qui pourraient être des cibles pour deux éventuels tr

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9

Arantes, Sílvia Alexandra Macedo. "Caracterização química e actividade biológica dos óleos essenciais e extractos aquosos de algumas Lavandula spp. do Sul de Portugal." Master's thesis, Universidade de Évora, 2012. http://hdl.handle.net/10174/17399.

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No presente trabalho estudaram-se três espécies do género Lavandula, do sul de Portugal: L. luisieri e L. pedunculata (Alentejo) e L.viridis (Algarve), com vista caraterizar a composição química dos óleos essenciais das diferentes espécies, parte vegetativa (folha) e espiga floral, e dos respetivos extratos de hidrodestilação, e avaliar as propriedades antioxidante, antimicrobiana, toxicológica, analgésica e antiinflamatória de alguns dos seus óleos essenciais e extratos aquosos, mais promissores. Os resultados mostraram importantes diferenças na composição química dos óleos essenciais, quanto

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10

Arantes, Sívia Alexandra Macedo. "Óleos essenciais de plantas aromáticas do Alentejo: caracterização química e potencial fitoterapêutic." Doctoral thesis, Universidade de Évora, 2020. http://hdl.handle.net/10174/27719.

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O Alentejo é uma região extremamente rica em plantas aromáticas e medicinais (PAM) muitas delas preservadas e consumidas em dietas diárias e também como ingredientes importantes na Dieta Mediterrânea. Adicionalmente, a par do crescente interesse dos produtos naturais como alternativas/complementos à terapêutica convencional, muitos são comercializados e adquiridos sem prescrição médica, regularmente usados em detrimento dos fármacos convencionais. De modo a possibilitar uma utilização segura das plantas e/ou dos seus óleos essenciais (OEs), é necessário um conhecimento preciso da relação entre

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11

Furuseth, Christina, and Therese Samuelsson. "Beskrivning av patienters postoperativa vårdförlopp tre dagar efter kolorektalkirurgi enligt ERAS vårdprogram." Thesis, University of Gävle, University of Gävle, Faculty of Health and Occupational Studies, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-7547.

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<p><strong><strong><p>Abstract</p><p>The purpose of this study was to describe the post-operative care during the three first days for patients who have undergone colorectal surgery according to ERAS care programs with a focus on the variables nutrition, elimination, activity, type of analgesia and the number of hospital days documented in the patient record and patient log books. ERAS means "Early Recovery After Surgery" and the purpose of the health care program is to accelerate recovery after colorectal surgery. The study had a descriptive design and a quantitative approach, in which 51 pat

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12

Farias, Fabiane Moreira. "Psychotria myriantha müll arg. (rubiaceae) : caracterização dos alcalóides e avaliação das atividades antiquimiotáxica e sobre o sistema nervoso central." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/8532.

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O gênero Psychotria destaca-se na família RUBIACEAE pela produção de alcalóides bioativos e por sua taxonomia complexa, sendo muitas vezes relacionado aos gêneros Palicourea, Cephaelis, Calycodendron e Calycosia. A divisão de Psychotria nos subgêneros Psychotria, Tetramerae e Heteropsychotria foi proposta com o objetivo de auxiliar a classificação quimiotaxonômica do gênero. Estudos demonstram que o subgênero Psychotria (espécies pantropicais) produz alcalóides poliméricos, formados por duas ou mais unidades de triptamina; enquanto o subgênero Heteropsychotria parece estar envolvido com a prod

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13

Soll, Lindsey G. "A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/696.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation channels that most notably influence dopamine (DA) release. In this thesis, I examine the role of nAChRs in mediating DA-related behaviors such as movement and drug dependence. To accomplish this, I utilized a “gain-offunction” knock-in mouse (the Leu9’Ala line) containing agonist-hypersensitive α4* nAChRs (* indicates other nAChR subunits in addition to α4 are within the receptor complex) that renders receptors 50-fold more sensitive to nicotine and acetylcholine than wild-type (WT) receptors. I found that DHβE, a sel

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14

Martínez, Jauand Mercedes. "Factores genéticos y psicosociales implicados en la modulación del dolor." Doctoral thesis, Universitat de les Illes Balears, 2013. http://hdl.handle.net/10803/125008.

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La La sensibilidad al dolor y el riesgo sufrir dolor crónico representan fenómenos complejos de naturaleza multidimensional, con una importante variabilidad interindividual. El objetivo de esta tesis doctoral se centró en explorar los factores genéticos y psicosociales implicados en la modulación del dolor y el riesgo a sufrir dolor crónico mediante seis estudios. Los dos primeros exploraron el efecto de factores genéticos y de la edad de inicio de la menopausia en la sensibilidad al dolor en pacientes con fibromialgia en comparación con voluntarias sanas. El primer estudio reveló un inc

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15

Bleger, Andrée. "Syntheses associatives au depart d'adenosine et d'agonistes gaba-ergiques." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13073.

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Synthese associative entre l'adenosine et le gaba ou des molecules apparentees. La substitution de l'adenosine par des analogues gaba-ergiques en position 6 a ete realisee soit par alkylation de l'azote n1 suivie d'un rearrangement de dimroth soit par substitution nucleophile du chloro-6 purine riboside. Des modifications au niveau de la sequence gaba et au niveau de l'adenosine ont ete envisagees. La comparaison des profils pharmacologiques de ces molecules a mis en evidence la necessite de la presence du ribose sur l'adenine et a montre que l'activite maximale correspondait au derive de l'ad

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16

Chang, Tien-Ning, and 張恬寧. "Studies on the Anti-oxidant, Hepatoprotective, Analgesic and Anti-inflammatory Activity of Hai-Fu-Rung." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/89461545639569360224.

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博士<br>中國醫藥大學<br>中國藥學暨中藥資源學系博士班<br>99<br>In this study, the chemical profile of water extract of Crossostephium chinensis (L.) Makino (CCW) and methanol extract of Limonium wrightii (Hance) Ktze.(LWM) was analyzed by LC-MS-MS spectrometer (high-performance liquid chromatography tandem mass). Chromatographic pattersn from HPLC analysis (254 nm) of rutin and scopoletin were detected in CCW. We then compared the results in anti-oxidant experiment with water and methanol extract of Crossostephium chinensis (L.) Makino (CCW, CCM) and Limonium wrightii (Hance) Ktze.(LWW, LWM). We also compared the an

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17

Machado, Rita Silvério de Magalhães. "Development and implementation of in vivo models for evaluation of drugs with potential analgesic activity." Master's thesis, 2010. http://hdl.handle.net/10216/69223.

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18

Machado, Rita Silvério de Magalhães. "Development and implementation of in vivo models for evaluation of drugs with potential analgesic activity." Dissertação, 2010. http://hdl.handle.net/10216/69223.

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19

Chang, Heng-yuan, and 張恒源. "Studies on the Anti-oxidant, Hepatoprotective, Analgesic,Anti-inflammatory and Anti-hepatoma Activity of Phellinus merrillii." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/76290450120407515504.

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博士<br>中國醫藥大學<br>中國藥學研究所博士班<br>95<br>Abstract The main aims of this study included establishing the ion fingerprinting pattern of Phellinus merrillii extracts by high-performance liquid chromatography tandem mass (LC/MS/MS) analysis, and evaluation of potential antioxidant activity of fraction components in P. merrillii. The effects of P. merrillii ethanol extracts on antioxidation, analgesia, anti-inflammation and hepatoprotection by carbon tetrachloride-induced hepatotoxicity were evaluated. Further assessment of the anti-carcinogenic activity and the mechanisms of its chemopreventive action

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20

Lin, Hsiao-Chun, and 林校群. "The brain activity changes of tactile allodynia and the analgesic effect of gabapentin in the neuropathic rats." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/94428827859727777302.

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博士<br>國立臺灣大學<br>生命科學系<br>103<br>Neuropathic pain is caused by injury or disease of the somatosensory system. Treating neuropathic pain is difficult because its pathophysiological mechanisms are understood limitedly. Tactile allodynia, the innocuous touch-evoked pain, is one of the major symptoms of neuropathic pain patients. So far the studies of tactile allodynia are focused on the functional alterations in the primary afferents and the spinal dorsal horn neurons, however, the role of brain in the tactile allodynia is still unclear. Gabapentin (GBP) is a first-line analgesic to treat neuropat

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21

Hillmann, Nadine. "Methodenvergleich zur Erfassung einer Restheparinisierung nach kardiochirurgischen Eingriffen mit Herz-Lungen-Maschine." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7CD3-9.

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22

Geibel, Stephan. "Vergleich von Anästhesieverfahren bei chirurgischen Eingriffen an der oberen Extremität." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3EC6-2.

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