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Dissertations / Theses on the topic 'Analgetic Agents'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Sadigh, Bita. "Analgetic and algetic effects of adenosine in healthy volunteers and patients with coronary artery disease /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-382-5/.

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2

Young, Shawquia Elithia. "Dual Mechanism Analgesia-Enhancing Agents." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/1166.

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Currently, there is an increasing need for novel analgesics that are potent but lack undesired side effects. Recent studies have shown that both 5-HT3 receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- adrenoceptor ligand. MD-354, inactive by itself, potentiates the antinociceptive effects of an inactive dose of clonidine in the mouse tail- flick assay. An attempt to determine the underlying mechanism of this pote

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3

Fraser, Mary I. "Uses of over-the-counter analgesic agents in the Montreal population." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0018/MQ44168.pdf.

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4

Laurila, née Kostamovaara P. (Päivi). "Pain relief after joint surgery:a clinical study." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514267958.

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Abstract Excessive pain after surgery causes many kinds of endocrine, metabolic and inflammatory responses, which may increase postoperative morbidity and mortality - especially among elderly patients. This study evaluated the effect of peripheral and central pain relief techniques after joint surgery. Intravenously administered doses of 100 mg, 200 mg and 300 mg of ketoprofen decreased the requirement for opioid (fentanyl) in a dose-dependent manner by 38%, 45% and 53%, respectively, compared with a placebo, without any noticeable ceiling-effect, when administered after hip and knee arthropl

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5

Mashimbye, Mahlori Jeffrey. "Isolation and identification of possible analgesics and antihypertensive agents from antidesma venosum." Thesis, Rhodes University, 1986. http://hdl.handle.net/10962/d1001616.

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This investigation originated from a suggestion by Noristan Laboratories, Pretoria, that because Black people were using the roots of A. venosum E. MEY. ex. TUL for treating headache, the plant might contain analgesics. No previous chemical investigation has been carried out on this plant but from previous work done on other species antihypertensive agents were expected to be present

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6

Main, David Campbell James. "Effects of dopaminergic, cholinergic and opioidergic agents in sheep and rat models of antinociception." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389233.

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7

Legeby, Mariann. "Opioid reducing strategies in post-operative pain management /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7357-016-8/.

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8

Nicol, Beverley. "The effect of anaesthetic and analgesic agents on glutamate uptake and release from rat neuronal preparations." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29503.

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In rat cerebrocortical and cerebellar synaptosomes the uptake of [3H]L-glutamate was time-, concentration-(Km=-8.6 and ~2.2M respectively), Na+-dependent and L-trans-PDC sensitive. In general the uptake mechanism was insensitive to clinically relevant concentrations of anaesthetics.;Perfused rat cerebrocortical slices depolarised with 2x2min pulses of 46mM K+ (S1 and S2) evoked monophasic releases of endogenous glutamate with an S2/S1 ratio of ~1.07. 0.1mM EGTA pre-treatment significantly inhibited evoked release, confirming a Ca2+ regulated exocytotic process.;A range of and , but not ligands

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9

Souza, Marília Trindade de Santana. "Síntese do propionato de carvacrol e estudo de suas propriedades anti-hiperalgésica e anti-inflamatória em protocolos." Pós-Graduação em Ciências Farmacêuticas, 2014. https://ri.ufs.br/handle/riufs/3931.

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Terpenes are naturally occurring compounds obtained from the plants secondary metabolism. Despite presenting pharmacological effects, structural changes within their skeleton may increasing their pharmacological activity and attenuate the toxicological effects. Carvacrol is a phenolic monoterpene present in essential oils from plants belonging to the Labiatae family. Studies have demonstrated that carvacrol has anti-inflammatory activity. However, sctructural changes may reduce the effective dose of this monoterpene. Thus, in this study, we conducted an extensive systematic review evaluating t

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10

Lam, Lay Andrea Tiap-Ling. "Estudio químico bioguiado de los extractos con actividad analgésica y antiinflamatoria de Adesmia atacamensis Phil." Tesis, Universidad de Chile, 2004. http://www.repositorio.uchile.cl/handle/2250/105396.

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11

Younessi, O. James. "Evaluation Of Cardiovascular Effects Of Bupivacaine And Role Of This Agent In Preemptive Analgesia." Thesis, Faculty of Dentistry, 1996. http://hdl.handle.net/2123/4613.

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12

Goldfarb, Allison. "Increasing Practitioner Knowledge of Ketamine as an Adjunct Analgesic for Postoperative Pain." UNF Digital Commons, 2014. http://digitalcommons.unf.edu/etd/517.

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Postoperative pain is of serious concern to patients and anesthesia providers alike. Management of a patients’ pain is a central component of anesthesia care. Ketamine as an anesthetic agent has been available for 50 years. It has been utilized as a general anesthetic and selectively as an anesthetic agent for high-risk patients. Due to dysphoric side effects associated with the dosage required to render general anesthesia, anesthesia providers may be reluctant to utilize this medication to its full potential. Recently there has been a resurgence of interest in ketamine as an analgesic agent.

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13

Isidora, Milanović. "Farmakološki efekti etarskog ulja ruzmarina Rosmarinus officinalis, L. (Lamiaceae), na miševima soja NMRI-Haan i pacovima soja Wistar." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. http://www.cris.uns.ac.rs/record.jsf?recordId=94338&source=NDLTD&language=en.

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Ruzmarin Rosmarinus officinalis L. (Lamiaceae) je biljka koja se u tradicionalnoj medicini na na&scaron;em području koristi za postizanje analgetičkog, holeretičkog i hepatoprotektivnog delovanja. Prema Evropskoj agenciji za lekove (2010 godine), indikacije za sistemsku primenu etarskog ulja ruzmarina su lečenje dispepsije i spazama gastrointestinalnog trakta, a za spolja&scaron;nju primenu se preporučuje u lečenju umereno jakih bolova u zglobovima i mi&scaron;ićima i u lečenju poremećaja periferne cirkulacije. Imajući u vidu da komponente etarskog ulja ruzmarina ispoljavaju i druga, potencija

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14

Gaujac, Cristiano [UNESP]. "Controle da dor e inflamação em cirurgia odontológica." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/88930.

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Made available in DSpace on 2014-06-11T19:23:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-02-22Bitstream added on 2014-06-13T19:26:49Z : No. of bitstreams: 1 gaujac_c_me_araca.pdf: 216269 bytes, checksum: 81a5fdfaa37a3ba2d8b2c9f81fe5d9b6 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A dor pode fazer parte ou não do processo inflamatório e significar a presença de dano ao organismo. É por meio dela que a maioria das afecções se manifesta. O cirurgião-dentista é responsável pela orientação ao paciente a respeito da dor esperada e sobre a estratégi

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15

Peters, Rodrigo Rebelo. "Avaliação de possíveis mecanismos de ação envolvidos na atividade antiinflamatória de produtos derivados de Wilbrandia ebracteata Cogn. e Luffa operculata (L.)." Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/85693.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.<br>Made available in DSpace on 2012-10-20T21:45:03Z (GMT). No. of bitstreams: 1 204945.pdf: 262144 bytes, checksum: db663bf54acf11b487a1120421fd357d (MD5)

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16

Heilborn, Umut. "Behavioural and neurochemical effects of long-lasting inflammatory pain /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-175-3/.

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17

Since, Marc. "Stratégie TDAE : outils synthétiques et applications pharmacochimique." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22953.

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Ce travail est consacré au développement de la stratégie TDAE dans le cadre de la synthèse de nouveaux composés à visée thérapeutique. Dans une première partie, la pharmacomodulation d’un composé potentiellement ligand sélectif du récepteur 5-HT7 nous a conduit à développer une méthodologie d’addition et d’estérification séquentielle « one-pot » initiée par le TDAE. Par la suite, nous avons étendu la réactivité initiée par le TDAE aux réactions de substitution nucléophile de type 2 sur des électrophiles -halogénoesters et -halogénoamides en série nitrobenzylique. Cette méthodol

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18

Gaujac, Cristiano. "Controle da dor e inflamação em cirurgia odontológica /." Araçatuba : [s.n.], 2006. http://hdl.handle.net/11449/88930.

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Orientador: Eduardo Hochuli Vieira<br>Banca: Élio Hitoshi Shinohara<br>Banca: Idelmo Rangel Garcia Júnior<br>Banca: Eduardo Hochuli Vieira<br>Resumo: A dor pode fazer parte ou não do processo inflamatório e significar a presença de dano ao organismo. É por meio dela que a maioria das afecções se manifesta. O cirurgião-dentista é responsável pela orientação ao paciente a respeito da dor esperada e sobre a estratégia de suavizá-la. Esse trabalho tem por objetivo elaborar um manual para que se possa fornecer aos clínicos e aos alunos de graduação informações e embasamento necessário para realizar

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19

Since, Marc. "Stratégie TDAE : outils synthétiques et applications pharmacochimique." Electronic Thesis or Diss., Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22953.

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Ce travail est consacré au développement de la stratégie TDAE dans le cadre de la synthèse de nouveaux composés à visée thérapeutique. Dans une première partie, la pharmacomodulation d’un composé potentiellement ligand sélectif du récepteur 5-HT7 nous a conduit à développer une méthodologie d’addition et d’estérification séquentielle « one-pot » initiée par le TDAE. Par la suite, nous avons étendu la réactivité initiée par le TDAE aux réactions de substitution nucléophile de type 2 sur des électrophiles -halogénoesters et -halogénoamides en série nitrobenzylique. Cette méthodol

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20

Arantes, Viviana Moraes Neder. "Analgesia preemptiva do cetoprofeno e do parecoxibe em cirurgia para remoção de terceiros molares inclusos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-29012007-153432/.

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Este trabalho prospectivo, duplo-cego randomizado, avaliou o efeito da analgesia preemptiva do cetoprofeno e do parecoxibe. Sessenta pacientes foram submetidos à cirurgia para remoção de terceiros molares inferiores bilaterais inclusos, sendo operado um lado de cada vez. O paciente foi seu próprio controle. Os pacientes foram separados em dois grupos de 30 pacientes. No grupo parecoxibe, na primeira operação foi usado o parecoxibe ou placebo, endovenoso, 30 minutos antes da cirurgia e imediatamente após a operação foi feita a administração do placebo ou parecoxibe, garantindo ao paciente receb

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21

Soll, Lindsey G. "A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/696.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation channels that most notably influence dopamine (DA) release. In this thesis, I examine the role of nAChRs in mediating DA-related behaviors such as movement and drug dependence. To accomplish this, I utilized a “gain-offunction” knock-in mouse (the Leu9’Ala line) containing agonist-hypersensitive α4* nAChRs (* indicates other nAChR subunits in addition to α4 are within the receptor complex) that renders receptors 50-fold more sensitive to nicotine and acetylcholine than wild-type (WT) receptors. I found that DHβE, a sel

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22

Dinsmore, Kristen, Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy PhD Brown, and Alexei MD Gonzalez-Estrada. "Refrigerated Stability of Diluted Cisatracurium, Rocuronium, and Vecuronium for skin testing after perioperative anaphylaxis." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/146.

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Rationale: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing. Methods: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, 10,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilutio

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23

Bleger, Andrée. "Syntheses associatives au depart d'adenosine et d'agonistes gaba-ergiques." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13073.

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Synthese associative entre l'adenosine et le gaba ou des molecules apparentees. La substitution de l'adenosine par des analogues gaba-ergiques en position 6 a ete realisee soit par alkylation de l'azote n1 suivie d'un rearrangement de dimroth soit par substitution nucleophile du chloro-6 purine riboside. Des modifications au niveau de la sequence gaba et au niveau de l'adenosine ont ete envisagees. La comparaison des profils pharmacologiques de ces molecules a mis en evidence la necessite de la presence du ribose sur l'adenine et a montre que l'activite maximale correspondait au derive de l'ad

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24

BATTILOCCHIO, CLAUDIO. "Development of a novel class of pharmacodynamic hybrids/no donors that targets cox-2 selectively and a machine-assisted flow procedure for the synthesis of meclinertant, a neurotensin receptor probe." Doctoral thesis, 2013. http://hdl.handle.net/11573/917006.

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The work described below is divided into two parts. In the first chapter, the development of a novel class of pharmacodynamic hybrids is discussed. These compounds are endowed with analgesic/anti-inflammatory properties along with their ability to release nitric oxide which makes them an important contribution to the development of effective COX-Inhibiting Nitric Oxide Donors. In the second chapter, the synthesis of an important neurotensin receptor antagonist (SR 48692, Meclinertant) is described. The synthesis of Meclinertant is achieved with the use of machine-assisted flow protocols t

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25

Hao-AnChan and 詹皓安. "Remotely Triggerable Microneedle as a Programmable Transdermal Delivery System for Analgesic Agents and it's Safety Assessment." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/28j2t4.

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碩士<br>國立成功大學<br>化學工程學系<br>102<br>In this study, we used biodegradable polycaprolactone (PCL), encapsulated analgesic agent – lidocaine and lanthanum hexaboride (LaB6) nanoparticles (NPs), to make remotely triggerable microneedle (MN). We focused on the feasibility of MN transdermally delivering analgesic agents and its safety assessment of clinical application. Lidocaine content in each MN patch was 1.58  0.17 mg (n = 4). After giving treatment of NIR, LaB6 NPs encapsulated in MN could convert the energy into heat leading to the melt of PCL and release drugs. The skin insertion tests showed t

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26

ching, chang ch'iao, and 張巧靜. "Influences the related factors of the will of using narcotic analgesics agents to nurses in the community in central Taiwan- nstance of morphine." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/25486089042927852228.

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碩士<br>亞洲大學<br>長期照護研究所<br>95<br>The cancer mortality has been the first killer among the ten major causes of death in recent years, the topic of the cancer pain control has paid more attention. In order to control the cancer pain effectively, the mainstream of the cancer pain control as using opiods analgesics in World Health Organization (WHO ). However, this kind of medicines often misunderstands in amount of people, and induces the pain control effects poorly, even influence the quality of life with the patient and their families. Because of cancer-caring develops and regards at home care an

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27

Ondua, Moise. "Antioxidative, analgesic and anti-inflammatory activities of Acokanthera oppositifolia, Plantago lanceolata, Conyza canadensis, and Artemisia vulgaris." Diss., 2015. http://hdl.handle.net/10500/19169.

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The anti-inflammatory properties of four medicinal plants were investigated. These plant extracts were subjected to screening for their possible effects as antioxidative, analgesic, and anti-inflammatory agents. In the antioxidant activity, the Plantago lancelota extracts resulted in an IC50 value of 0.4 mg/mL compared to the positive control quecertin with IC50 0.04 mg/mL Plantago lanceolata inhibited COX-2 activity with IC50 values of 0.41 mg/mL. However, the COX-1 inhibition indicated an IC50 of 68.99 mg/mL. The lipoxygenase assay indicated that Plantago lanceolata was the most active plant

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28

Mackintosh, Carolyn, and Sue Elson. "Chronic pain: clinical features, assessment and treatment." 2008. http://hdl.handle.net/10454/6969.

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A significant number of people in the UK experience chronic pain, resulting in high levels of suffering and reduced quality of life. Management of chronic pain is complex, time consuming and not always successful. Good communication between patients and healthcare professionals is essential to ensure realistic treatment plans and outcomes can be negotiated. Accurate assessment is also key, and nurses play a fundamental role in ensuring patients with chronic pain receive the most appropriate care.

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29

Lizarraga-Madrigal, Ignacio. "Spinal analgesic interaction between non-steroidal anti-inflammatory drugs and N-methyl-D-aspartate receptor systems : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Science, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand." 2006. http://hdl.handle.net/10179/1466.

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Activation of spinal N-methyl-D-aspartate (NMDA) receptors stimulates cyclooxygenase and nitric oxide pathways. Compounds that block the activity of these NMDA receptor systems reduce pain hypersensitivity. However, their usefulness is limited by the side effects they produce. One way of reducing side effects is by combining drugs that produce the same overt effect by different mechanisms, which hopefully increase the net effect. In these series of studies, drugs that interact with NMDA receptor systems and their combinations were screened in vitro to identify spinal antinociceptive synergisti

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30

Patil, S. S., E. Venugopal, S. Bhat, K. R. Mahadik, and Anant R. Paradkar. "Microstructural elucidation of self-emulsifying system: effect of chemical structure." 2012. http://hdl.handle.net/10454/6124.

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PURPOSE: Self-emulsifying systems (SES) emulsify spontaneously to produce fine oil-in-water emulsion when introduced into aqueous phase. The self-emulsification process plays an important role during formation of emulsion. The objective of current work was to understand and explore the inner structuration of SES through controlled hydration and further to study the influence of additive on the same which ultimately governs performance of final formulation in terms of droplet size. METHODS: Droplet size of final formulations containing structural analogues of ibuprofen was determined. Microstru

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