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Dissertations / Theses on the topic 'Analogies. eng'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Bozelli, Fernanda Cátia. "Saberes docentes mobilizados em contextos interativos discursivos de ensino de física envolvendo analogias /." Bauru : [s.n.], 2010. http://hdl.handle.net/11449/102034.

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Orientador: Roberto Nardi<br>Banca: Odete Pacubi Baierl Teixeira<br>Banca: Silvania Sousa do Nascimento<br>Banca: Isabel Martins<br>Banca: Sandra Regina Teodoro Gatti<br>Resumo: Compreender o papel da linguagem na Educação em Ciências tem sido o objeto de investigação de estudos para diversos pesquisadores nos últimos tempos. Além disso, verifica-se, também uma mudança na maneira de compreender o papel da linguagem na educação científica. Ou seja, tem havido um crescente interesse sobre a natureza das interações entre professores e alunos visando à construção de conhecimentos científicos, e so

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2

Bozelli, Fernanda Cátia. "Analogias e metáforas no ensino de física : o discurso do professor e o discurso do aluno /." Bauru : [s.n.], 2005. http://hdl.handle.net/11449/90890.

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Orientador: Roberto Nardi<br>Banca: Eduardo Adolfo Terrazan<br>Banca: Washington Luiz Pacheco de Carvalho<br>Resumo: As relações entre linguagem e ensino de ciências têm sido objeto constante de pesquisa nos últimos anos, tendo se constituído numa promissora linha de investigação na área de Educação em Ciências. Dentre essas pesquisas, destacam-se os estudos sobre a utilização das analogias e metáforas enquanto recurso didático mediador entre os procesos de ensino e de aprendizagem. No caso específico da pesquisa em Ensino de Física, muitos dos pesquisadores têm mostrado interesse no levantame

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3

Jimenez, Rosales Angelica. "Methyltransferases as bioorthogonal labelling tools for proteins." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/methyltransferases-as-bioorthogonal-labelling-tools-for-proteins(27231f93-7cdd-4c2d-9f31-0adc3f38b147).html.

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Development of enzymatic labelling methods has been driven by the importance of studying molecular structures and interactions to comprehend cellular processes. Methyltransferases (MTases), which regulate genetic expression by transferring a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to DNA, histones and various proteins, have been shown to accept SAM analogues with an alternative alkyl group on the sulfonium centre. These alkyl groups can be transferred to the substrate, and with a further reaction can be selectively functionalized. Thus, MTases together with SAM analogues h

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4

Trevisan, Marlon Dantas. "O papel da metáfora/analogia no ensino de ciências : uma abordagem semiótica /." Bauru : [s.n.], 2008. http://hdl.handle.net/11449/90868.

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Orientador: Marcelo Carbone Carneiro<br>Banca: Lauro Frederico Barbosa da Silveira<br>Banca: Ana Maria de Andrade Caldeira<br>Resumo: Esta pesquisa tem como meta investigar o uso da metáfora/analogia no ensino de ciências. Para tal, alicerçamo-nos no referencial semiótico peirceano, uma vez que o mesmo constitui-se sólida herança para os estudos de filosofia da linguagem. O discurso científico sempre abrigou um paradoxo: ao mesmo tempo em que propõe um registro objetivo, denotativo, comumente lança mão de metáfora/analogias, como recurso para transmitir e auxiliar a construção de conceitos. Um

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5

Fernandes, Paulo Cézar. "Sobre respeito e autonomia em Kant /." Marília : [s.n.], 2009. http://hdl.handle.net/11449/93154.

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Orientador: Ubirajara Rancan de Azevedo Marques<br>Banca: Oswaldo Giacóia Júnior<br>Banca: Aylton Barbieri Durão<br>Resumo: Este trabalho tem por objetivo apresentar alguns conceitos chave da filosofia prática de Kant, especialmente respeito e autonomia, bem como o caminho percorrido pelo filósofo para formulação de uma possibilidade para a liberdade prática. Esse percurso será investigado principalmente junto de duas obras, a saber, Fundamentação da metafísica dos costumes e Crítica da razão prática. Nelas Kant apresenta o respeito como um sentimento que é produzido pela consciência da lei mo

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6

Abu, Ajaj Khalid. "Synthesis of Phosphonate Analogues of the Antibiotic Moenomycin A12." Doctoral thesis, Universitätsbibliothek Leipzig, 2004. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-37333.

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SUMMARY The moenomycin-type compounds are known to inhibit selectively the enzyme penicillin binding protein 1b (PBP 1b) that catalyses the transglycosylation reaction in the biosynthesis of bacterial cell wall peptidoglycan. The moenomycins (see moenomycin A12) have been shown to interfere with this biosynthetic step interacting with the enzyme(s). The moenomycins do not induce resistance readily. A weak point in this respect may, however, be the phosphate bond to unit F. Its cleavage by a yet poorly characterized enzyme is the only enzymatic degradation reaction of the moenomycins that is kn

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7

Aissa, José Carlos. "Analogias e contrastes na poesia de Alphonsus de Guimaraens e de Edgar Allan Poe /." São José do Rio Preto : [s.n.], 2006. http://hdl.handle.net/11449/106347.

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Orientador: Carlos Daghlian<br>Banca: Giséle Manganelli Fernandes<br>Banca: Maria Cecília Queiroz de Moraes Pinto<br>Banca: Maria Clara Bonetti Paro<br>Banca: Rogério Elpídio Chociay<br>Resumo: O propósito desta tese é o de estabelecer analogias e contrastes entre Edgar Allan Poe e Alphonsus de Guimaraens em relação aos preceitos estéticos que decidiram imprimir a sua produção poética, mormente quanto aos temas de amor (Eros) e morte (Tânatos). Procuramos demonstrar que esses matizes temáticos são trabalhados sob a angulação do góticomelancólico a fim de se atingir o sublime. Nos quatro primei

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8

Lechner, Andreas. "Flexible embedded test solutions for high-spped analogue front-end circuits." Thesis, Lancaster University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411888.

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9

Dotti, Amanda Foganholi. "O uso de analogias no processo didático : um estudo sobre livros de ciências para a última série do ensino fundamental /." Araraquara : [s.n.], 2007. http://hdl.handle.net/11449/90334.

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Orientador: Vera Teresa Valdemarin<br>Banca: Maria Cristina Senzi Zancul<br>Banca: Kazumi Munakata<br>Resumo: Uma das possíveis finalidades da escola é a de tornar a cultura acessível aos alunos por meio da transposição didática, produzindo o saber escolar. Dentre os agentes que realizam a transposição didática estão o professor e o livro didático e, freqüentemente o recurso didático selecionado para realizar a transposição é a analogia, que permite associar o conteúdo a ser ensinado a um conhecimento prévio que se pressupõe que o aluno detenha e tem sido empregada como alternativa para explic

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10

Devert, Marie. "Synthèse totale de deux nouveaux analogues de la camptothécine modifiés sur le cycle E." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00622972/en/.

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La 20(S)-camptothécine (CPT) est un alcaloïde pentacyclique doté d'une activité anticancéreuse remarquable, agissant comme inhibiteur de la topoisomérase I (topo I). Le problème majeur de ce composé (et de la plupart de ses dérivés) est la fragilité de son cycle E qui s'hydrolyse rapidement à pH physiologique pour conduire au carboxylate correspondant inactif. L'une des approches permettant de pallier ce problème d'hydrolyse consiste à modifier le cycle E. Ce travail de thèse porte sur la synthèse totale de deux nouveaux analogues de la CPT modifiés au niveau du cycle E. Chacune de ces synthès

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11

Baccar, Sahbi. "Etude et modélisation comportementale de « front-end » analogiques pour des environnements « fond de puits »." Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14613.

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Cette thèse s’inscrit dans le domaine de la modélisation des circuits analogiques et mixtes.Le travail part d’une problématique industrielle concernant les circuits électroniques utilisés dansles systèmes de forage pétrolier pour des besoins d’instrumentation et mesures. Ce travail de recherche concerne les circuits du front-end analogique que nous trouvons dans cette application industrielle. Nous examinons et nous essayons de trouver des modèles pour décrire l’effet des hautes températures sur les circuits électroniques dans un forage pétrolier. Ces circuits font partie des circuits industri

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12

Lee, Jasmine. "The design and preparation of pyridoxal 5'-phosphate analogues." Thesis, Abertay University, 2002. https://rke.abertay.ac.uk/en/studentTheses/2576be85-8cca-4f11-89ab-f1159fa57f94.

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13

Savio, Nicolas Domingo. "Forecasting the effectiveness of policy implementation strategies." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/forecasting-the-effectiveness-of-policy-implementation-strategies(7d560826-a9bf-4223-8658-02240934ade9).html.

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An important stage in the policy process involves deciding what strategy is to be adopted for implementation so that the objectives of the policy are met in the best way possible. A Policy Implementation Strategy (PIS) adopts a broad view of implementation, which is argued to transcend formulation and decision-making, thereby offering a more realistic view of the policy process. Governmental decision-makers are often faced with having to choose one PIS amongst several possible alternatives, at varying cost levels. In order to aid in such a decision-making process, PIS effectiveness forecasts a

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14

Li, Jiahao. "Heterogeneously integrated impedance based biosensors." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277259.

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The salient issues of integrated biosensors on a complementary metal-oxide semiconductor (CMOS) platform are the limited transducer design and the need for post-processing. To overcome these issues, a heterogeneously integrated system, which employs both CMOS and large-area processing, was proposed and developed. The system presented, could become a rapid, low-cost and disposable sensing platform for point-of-care applications. The heterogeneously integrated system, comprising a CMOS front-end circuit and disposable electrodes, was applied to measure the impedance of suspended DNA at different

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15

Fazakerley, Neal James. "The total synthesis of (+)-pleuromutilin and novel analogues." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-total-synthesis-of-pleuromutilin-and-novel-analogues(b665d0f5-9231-4c2d-a803-c88f56e50202).html.

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The increasing emergence of multi-drug-resistant microorganisms has led the World Health Organisation to plead for action to be taken against antimicrobial resistance. The fungal secondary metabolite (+)-pleuromutilin displays antibacterial activity with a novel mode of action: pleuromutilin derivatives bind to functionally important nucleotides within the peptidyl transfer centre of the prokaryotic ribosome and inhibit bacterial protein synthesis. The first non-racemic total synthesis of the antibiotic natural product pleuromutilin has been developed. A chiral pool strategy has been employed

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16

Arno, Maria Chiara. "Design, synthesis and biological evaluation of hepcidin analogues." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/design-synthesis-and-biological-evaluation-of-hepcidin-analogues(58e746c7-dbd9-4cbe-904c-0e5abe5b24b7).html.

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Hepcidin is a peptide hormone involved in the control of iron homeostasis. It has 25 amino acids with an antiparallel beta-sheet structure stabilized by four disulfide bonds. Hepcidin binds to the sole known iron exporter, ferroportin, leading to its internalization and degradation by a mechanism not fully understood. Hepcidin has an important role in iron metabolism disorders, such as hemochromatosis and anaemia. However, hepcidin analogues are currently not available for clinical use. The aims of this project are twofold: - to design and synthesise a fluorescent hepcidin analogue that can be

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17

Maikowski, Leo M. "Toleranced multiple fault diagnosis of analogue circuits." Thesis, University of Brighton, 1995. https://research.brighton.ac.uk/en/studentTheses/61464794-ec3e-4bcb-b091-fd3d69ec8ecf.

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The implementation of an automatic fault diagnosis approach for analogue circuits is facing a number of problem areas. They are typically: component and measurement tolerances, circuit size, limited observability constraints, multiple fault conditions, non-linear behaviour, speed and generic applicability. Since such fault finding techniques utilize circuit simulations sometime during the diagnostic process, the preferred form of classification amongst researchers is a taxonomy of Simulationbefore-Test (SbT) and Simulation-after-Test (SaT) methods. A survey of related work following these two

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18

Wiederhold, James Edward. "Toward the standardization of use-wear studies : constructing an analogue to prehistoric hide work /." Thesis, [College Station, TX] : Texas A & M University, 2004. http://hdl.handle.net/1969/1262.

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19

Fituri, Hisham Saleh. "Synthesis of uracil containing precursors and analogues of cylindrospermopsin." Thesis, Bangor University, 2015. https://research.bangor.ac.uk/portal/en/theses/synthesis-of-uracil-containing-precursors-and-analogues-of-cylindrospermopsin(3d8eff07-e38b-4988-b4d6-b7942a797035).html.

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The thesis covers three topics: i) Synthesis of the uracil D-ring precursor of the cylindrospermopsin alkaloids: this study entailed the preparation of compounds I and II which were shown to be a RHS D-ring precursor in the synthesis of the cylindrospermopsin alkaloids. Compound I was prepared in 3 steps and in 24% overall yield from dibenzylurea whilst II was prepared from either diethyl 1,3-acetonedicarboxylate in 5 steps and 9% overall yield or barbituric acid in 5 steps and 16% overall yield. ii) Preparation of analogues of cylindrospermopsin: the synthesis of the cylindrospermopsin analog

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20

Peartree, Philip Neil Alexander. "Simulation studies of aromatic amine dehydrogenase bound phenylethylamine analogues." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/simulation-studies-of-aromatic-amine-dehydrogenase-bound-phenylethylamine-analogues(5ea2720e-b66a-4287-b2b8-eb4793a966d7).html.

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A series of para-substituted phenylethylamine analogues bound to the enzyme aromatic amine dehydrogenase have been simulated using quantum mechanical electronic structure calculations and molecular mechanical molecular dynamics simulations. Trends have been verified connecting bond dissociation energy (and thus driving force) to observed rate constants and activation enthalpy. Trends have been identified in connecting statistics drawn from molecular dynamics simulations and the temperature dependence of the kinetic isotope effect, notably that as the temperature dependence of the kinetic isoto

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21

Huang, Xiangchen. "Design, synthesis and antimalarial evaluation of novel azafluorenone analogues." Thesis, King's College London (University of London), 2016. http://kclpure.kcl.ac.uk/portal/en/theses/design-synthesis-and-antimalarial-evaluation-of-novel-azafluorenone-analogues(db1ba299-7387-41c5-965f-7ca038dd98e7).html.

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With the rapid spread of drug resistance to chloroquine, the development of effective, safe, and affordable antimalrial drugs has become one of the most pressing health priorities worldwide. Two azafluorenone alkaloids isolated from Mitrephora diversifolia have been proved to possess antimalarial activity against chloroquine-resistant Plasmodium falciparum. To explore the structure-activity relationship of the azafluorenone family, twenty four analogues with various structural modifications have been prepared via a concise synthetic route utilising Suzuki cross-doupling reactions and intramole

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Gorelik, Andrii. "Genetic encoding of a stable O-GlcNAc analogue." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/ffddce97-0762-4c2b-96fb-d7a3666acffd.

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Attachment of N-acetylglucosamine to hydroxyl groups of serine and threonine residues of intracellular proteins is known as <i>O</i>-GlcNAcylation, an essential posttranslational event in mammals and most other metazoa, catalysed by a unique <i>O</i>-GlcNAc transferase (OGT) and removed by an <i>O</i>-GlcNAc hydrolase (OGA). Despite the existence of a single writer/eraser pair, proteomic studies have identified over 4000 O-GlcNAcylated proteins in the nucleus, cytoplasm and mitochondria of various organisms, ranging from <i>C. elegans </i>to human. However, the molecular and biological mechani

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23

Seers, Thomas Daniel. "Image based characterisation of structural heterogeneity within clastic reservoir analogues." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/image-based-characterisation-of-structural-heterogeneity-within-clastic-reservoir-analogues(30de0147-57d2-428f-8a10-1b48476476a3).html.

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The presence of subseismic scale faulting within high porosity sandstone reservoirs and aquifers represents a significant source of uncertainty for activities such as hydrocarbon production and the geologic sequestration of carbon dioxide. The inability to resolve geometrical properties of these smaller scale faults, such as size, connectivity and intensity, using conventional subsurface datasets (i.e. seismic reflection tomography, wireline log and core), leads to ambiguous representations within reservoir models and simulators. In addition, more fundamental questions still remain over the ro

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24

Martin, Dayl. "IR spectroscopy of planetary regolith analogues, lunar meteorites, and Apollo soils." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/ir-spectroscopy-of-planetary-regolith-analogues-lunar-meteorites-and-apollo-soils(366e3992-f823-4e88-8c5c-0fcea1d25fe8).html.

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The main objectives of this study are to determine how various physical and chemical properties of geologic samples can be investigated by Fourier Transform InfraRed (FTIR) spectral analyses, and determine how each of these individual properties uniquely alter the mid-infrared spectrum. Of particular interest is how extraterrestrial samples differ (spectrally) from terrestrial samples, and how such findings can be applied to current and future missions to airless planetary bodies (such as Diviner Lunar Radiometer, aboard the Lunar Reconnaissance Orbiter, and the Mercury Thermal Radiometer on B

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25

Obi, Juliana. "Synthesis of analogues of dicoumarol and their measurement as inhibitors of NQO1." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-analogues-of-dicoumaroland-their-measurementas-inhibitors-of-nqo1(985aa4d2-437d-46ff-aadd-8f72ab9887c9).html.

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A variety of novel and effective inhibitors of NQO1 was synthesized. The inhibitors were classified as 'asymmetrical' and 'halfway stage' analogues of dicoumarol. The synthesis of these inhibitors was achieved through the application of different techniques such as 'borrowing hydrogen methodology', thermal and microwave irradiation and reductive C-C cleavage using NaBH3CN. One of the most potent analogues was toxic (IC50 = 9.2 ± 0.3 μM) towards the non-small cell lung cancer cell line, A549.A selection of the most potent inhibitors was re-modified as prodrugs in order to improve drug penetrati

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26

Chi, Hung Nguyen. "Synthèse et étude de nouveaux analogues tetracycliques et tricycliques des ellipticines et aza-9 ellipticines." Paris 11, 1985. http://www.theses.fr/1985PA112290.

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La présente thèse concerne la synthèse de nouveaux analogues tétracycliques et tricycliques des Ellipticines et aza-9 Ellipticines, ainsi que l'étude de L'étude de leurs propriétés biologiques. L’étude de la lithiation des furo-et pyrrolo [3,2-c] pyridines présentée dans le premier chapitre montre que l'échange avec le ter. Butyl lithium s'effectue sur le sommet 2 de ces hétérocycles. Cela permet d'accéder à divers dérivés fonctionnalisés sur leur sommet 2 à partir desquels nous avons pu accéder d'une part à des pyrido [4,3-b] benzo [f] indoles et d'autre part à des pyrido [3',4': 4,5] pyrrolo

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27

Hiorns, R. E. "D.S.P. of circuit design for P.W.M. D/A conversion." Thesis, King's College London (University of London), 1994. https://kclpure.kcl.ac.uk/portal/en/theses/dsp-of-circuit-design-for-pwm-da-conversion(5da641f8-747f-42ff-be70-c0e0bed22676).html.

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28

Greenway, Charlotte W. "Children solving analogical problems : insights from a cross sectional and microgenetic study using video analogues." Thesis, University of South Wales, 2010. https://pure.southwales.ac.uk/en/studentthesis/children-solving-analogical-problems(04e4b7d4-dc99-459c-b091-47b48591dd90).html.

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The present study examined young children’s analogical performance and strategy use in both classical and problem analogies in an attempt to bridge the gap between children’s strategy use across both types of analogy. There were three studies in all; the classical analogy tasks monitored sixty-four, 3, 4 and 5-year-olds’ performance on two separate occasions, six months apart; study 2 monitored thirty-four, 3 and 4-year-olds’ strategy use on problem analogies, at week one and week 30; and the microgenetic study followed thirty, 4 and 5-year-olds strategy use over a 30 week period, at weekly in

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Haensele, Elke. "Long-scale molecular dynamics simulations of cyclic peptide hormones vasopressin, urotensin and analogues." Thesis, University of Portsmouth, 2017. https://researchportal.port.ac.uk/portal/en/theses/longscale-moleculardynamics-simulations-of-cyclic-peptide-hormones-vasopressin-urotensin-and-analogues(46b7b189-c975-4d37-9098-d747e2111058).html.

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This thesis describes unrestrained microsecond‐scale molecular‐dynamics (MD) simulations of the structurally related peptide hormones Arg<sup>8</sup>‐vasopressin (AVP), urotensin II (UII), urotensin‐related peptide (URP), Leu<sup>8</sup>‐oxytocin (OT) and analogous. All are agonistic ligands of G‐protein coupled receptors that regulate a multitude of physiological functions. They are thus, connected with many pathophysiological processes, making them a major target for drug design. The common structural feature of these intrinsically flexible peptides is a cyclic 6‐residue moiety closed by a d

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Clayton, James. "Dearomatising addition of organolithiums to 2-aryloxazolines : a route to amino-carbasugar analogues." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/dearomatising-addition-of-organolithiums-to-2aryloxazolines-a-route-to-aminocarbasugar-analogues(bf2be92f-71f0-47b7-91d2-247ab9452ab0).html.

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2-Aryl-4,5-anti-diphenyloxazolines undergo nucleophilic dearomatising addition to the 2-aryl group when treated with secondary organolithiums at -78 °C in the presence of the deaggregating co-solvent DMPU. Quenching the reaction with methyl iodide gives a highly substituted conjugated diene. Quenching the reaction with a proton source gives a substituted unconjugated 1,4-diene. The stereochemistry of the anti-diphenyl oxazoline controls the diastereoselectivity of the nucleophilic addition; only one diastereoisomeric product is observed. Importantly these conditions allow the dearomatisation o

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Mears, Paul. "Approaches towards the synthesis of the 20-deoxybryostatins and their 20,20-difluorinated analogues." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/approaches-towards-the-synthesis-of-the-20deoxybryostatins-and-their-2020difluorinated-analogues(82de5040-e32f-45fb-9537-8a5eaed7c67b).html.

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This thesis describes approaches towards the synthesis of 20-deoxybryostatins and 20,20-difluorobryostatins. Towards the 20-deoxybryostatins, a route previously developed within the group was followed with a protecting group change designed to prevent problems encountered with a late-stage deprotection. To this end, (R)-pantolactone was transformed through to dimethyl (4S,6R,8R)-[4-(para-methoxybenzyloxy)-10-hydroxy-6,8-O-isopropylidine-3,3-dimethyl-2-one] phosphonate which was subsequently subjected to a Horner-Wadworth-Emmons condensation with (5R,E)-6-(4-methoxybenzyloxy)-5-triethylsilyloxy

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Mailand, Marko. "Systemanalyse und Entwicklung Six-Port basierter Funkempfängerarchitekturen unter Berücksichtigung analoger Störeffekte." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1199900991755-90088.

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Due to the increasing demand of broadband capability and reconfigurability for mobile applications, there is an enormous interest to develop appropriate analog receiver front-ends. In this respect, one promising candidate group is the Six-Port-based direct conversion receiver. The presented work focuses on the investigation of Six-Port-based mobile receiver front-ends with their specific systematical signal processing. Thereby, issues of spurious interfering signals which are generated within the down conversion process of such receivers are of special interest. Based on a comprehensive descri

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Mailand, Marko. "Systemanalyse und Entwicklung Six-Port basierter Funkempfängerarchitekturen unter Berücksichtigung analoger Störeffekte." Doctoral thesis, Technische Universität Dresden, 2007. https://tud.qucosa.de/id/qucosa%3A24036.

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Due to the increasing demand of broadband capability and reconfigurability for mobile applications, there is an enormous interest to develop appropriate analog receiver front-ends. In this respect, one promising candidate group is the Six-Port-based direct conversion receiver. The presented work focuses on the investigation of Six-Port-based mobile receiver front-ends with their specific systematical signal processing. Thereby, issues of spurious interfering signals which are generated within the down conversion process of such receivers are of special interest. Based on a comprehensive descri

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Nguyen, Thi Ai Nhung, Thi Phuong Loan Huynh, and Van Tat Pham. "Quantum chemical investigation for structures and bonding analysis of molybdenum tetracarbonyl complexes with N-heterocyclic carbene and analogues: helpful information for plant biology research." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-190465.

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Quantum chemical calculations at the gradient-corrected (BP86) density-functional calculations with various basis sets (SVP, TZVPP) have been carried out for Mo(CO)4 complexes of Nheterocyclic carbene and analogues-NHEMe (called tetrylenes) with E = C, Si, Ge, Sn, Pb. The equilibrium structures of complexes [Mo(CO)4-NHEMe] (Mo4-NHEMe) exhibit an interesting trend which the lightest adduct Mo4-NHCMe has a trigonal bipyramidal coordination mode where the ligand NHCMe occupies an equatorial position. In contrast, the heavier species from Mo4-NHSiMe to Mo4-NHPbMe possess a square pyramidal structu

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Izquierdo, Christian. "Conception et réalisation d’un front-end analogique pour un récepteur multistandard multi-mode." Thesis, Lille 1, 2011. http://www.theses.fr/2011LIL10013/document.

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L‘objectif de la thèse est la conception d’un front-end analogique RF large bande pour récepteurs cellulaires multistandard multi-mode. La principale limitation des récepteurs actuels par rapport à cet objectif est la nécessité d’un filtre SAW externe afin de protéger le LNA et le mélangeur des bloqueurs hors bande. Nous proposons dans cette thèse une technique de contre-réaction positive, basée sur la transposition de fréquences, qui permet un filtrage RF sélectif dès l’entrée du récepteur. Cette architecture diminue les contraintes de linéarité dès l’entrée du LNA. Ce filtrage est en plus re

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Quesne, Matthew. "Computational studies of naturally occurring, transition metal dependent, oxygen activating enzymes and their synthetic analogues." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/computational-studies-of-naturally-occurring-transition-metal-dependent-oxygen-activating-enzymes-and-their-synthetic-analogues(49d652fe-9ce9-491a-abf4-76feafdb7a68).html.

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Iron containing metalloenzymes are an extremely important class of biocatalysts conserved throughout evolution because of their vital role in the biochemistry of life. Here we discuss a specific class of these enzymes that use molecular oxygen binding to enable there activity. We also attempt to describe synthetic analogues whose chemistry is based on that seen in those natural systems. This dissertation will highlight how computational research can illuminate specific aspects of the reaction mechanisms that these systems catalyse, which in many cases are unable to be understood purely experim

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Pöschl, Anna. "Synthesis of novel piperidine building blocks and their use for the preparation of donepezil analogues." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/synthesis-of-novel-piperidine-building-blocks-and-their-use-for-the-preparation-of-donepezil-analogues(7bca2c61-fc01-4496-adb5-b42872749a34).html.

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The piperidine moiety is found in a vast number of bioactive natural products as well as numerous marketed drugs and is therefore an interesting target for synthetic modi cations. Synthetic piperidines currently in the clinic are predominantly limited to 1,4-disubstitution on the piperidine ring, hence it is important to develop strategies to access new drug candidates with diverse substitution con gurations on the ring. For this purpose, the aza-Michael reaction can be used as an atom-ecient method to access biologically important piperidines. An initial study into the utility of divinyl keto

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Warnock, Kristen. "The role of rumination in PTSD symptom maintenance : an analogue study." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-rumination-in-ptsd-symptom-maintenance(12d94f6d-57fb-43fc-94e5-354fc60a5f04).html.

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It has been well-observed in the literature that not every individual who experiences a traumatic event will go on to develop post-traumatic stress disorder (PTSD). Given this, a key focus within the field has been the examination of those factors which might serve to maintain PTSD symptomatology. In recent years, the potential role of rumination within disorder maintenance has been afforded greater attention, with accumulating evidence from clinical and non-clinical (analogue) studies to suggest its involvement. The evidence-base in this area thus far is outlined, with particular consideratio

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Nguyen, Thi Ai Nhung, Thi Phuong Loan Huynh, and Van Tat Pham. "Quantum chemical investigation for structures and bonding analysis of molybdenum tetracarbonyl complexes with N-heterocyclic carbene and analogues: helpful information for plant biology research: Research article." Technische Universität Dresden, 2014. https://tud.qucosa.de/id/qucosa%3A29085.

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Quantum chemical calculations at the gradient-corrected (BP86) density-functional calculations with various basis sets (SVP, TZVPP) have been carried out for Mo(CO)4 complexes of Nheterocyclic carbene and analogues-NHEMe (called tetrylenes) with E = C, Si, Ge, Sn, Pb. The equilibrium structures of complexes [Mo(CO)4-NHEMe] (Mo4-NHEMe) exhibit an interesting trend which the lightest adduct Mo4-NHCMe has a trigonal bipyramidal coordination mode where the ligand NHCMe occupies an equatorial position. In contrast, the heavier species from Mo4-NHSiMe to Mo4-NHPbMe possess a square pyramidal structu

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40

Sumoreeah, Ravi Leckman. "Studies towards the total synthesis of galanthamine and the total synthesis of 2-Benzoyl-9-azabicyclo[4.2.1]non-2-ene : phenyl analogue of (#+-#)Anatoxin-a." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289225.

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This thesisd escribess yntheticw ork carriedo ut on two separatep rojects. (i) Synthetics tudiest owardst he total synthesiso f galanthamine (ii) The total synthesis of 2-Benzoyl-9-azabicyclo[4.2.1 ]non-2-ene Galanthamine is an amaryllidaceae alkaloid processing a rigid tetracyclic structure with a fused dihydrobenzofuran onto a cyclohexenol and a bridging tertiary amine. 2-Benzoyl-9-azabicyclo[4.2.1]non-2-ene is an analogue of anatoxin-a, whereby the acetyl side chain has been substituted with a benzoyl group. Anatoxin-a itself possesses a 9-azabicyclo[4.2.1]nonane framework. Although structu

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Rarity, Gil. "Digital outcrop characterisation of syn-rift structure and stratigraphy : Nukhul half-graben, Suez Rift, Egypt." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/digital-outcrop-characterisation-of-synrift-structure-and-stratigraphy-nukhul-halfgraben-suez-rift-egypt(6969e8ae-4039-4d36-861b-de4496492488).html.

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Syn-rift exposures are a prime source of knowledge on the structure and stratigraphy of rift basins and are vital for the petroleum industry as analogues for subsurface reservoirs. Focusing on superb exposures of the Oligo-Miocene rift initiation Nukhul half-graben in the Suez Rift, Egypt, this study investigates applications of 3D digital survey techniques, particularly terrestrial light detection and ranging (lidar), for (i) the analysis of syn-rift fault and facies architecture, and (ii) the building and testing of outcrop-based reservoir analogue models for early syn-rift settings. Lidar-b

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Adegbesan, Bukunola. "Investigation of the anti-cancer properties of natural products and synthetic analogues with NQO2 inhibiting potential." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-the-anticancer-properties-of-natural-products-and-synthetic-analogues-with-nqo2-inhibiting-potential(58988735-61c8-455b-ad49-69678d7f5869).html.

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Research Background: Quinone oxidoreductase is a family of proteins consisting of the NRH quinone oxidoreductase 2 (NQO2) and the NADPH quinone oxidoreductase 1 (NQO1) enzymes which are involved in the two-electron reduction and detoxification of quinones and their derivatives. The biological function of NQO2 has not yet been elucidated but it has been shown that its genetic knockdown in hepatoblastoma cells resulted in reduction in the level of p53 while its induction in keratinocytes leads to p53 activation thus indicating that NQO2 is associated with p53 stability and prevention of its degr

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Siddeeg, Saif Eldin Mohammed Babiker. "Geochemistry of natural radionuclides in uranium-enriched river catchments." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/geochemistry-of-natural-radionuclides-in-uraniumenriched-river-catchments(c32e80c3-413a-4513-a0a6-fd3a705abd99).html.

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Radionuclides from natural U-series in sediments from two river catchments in the UK have been studied. The aim was to gain insight into the behaviour of 238U, 234U, 230Th and 226Ra in real natural systems enriched in uranium. A radiochemical method for radium separation followed by alpha spectrometric measurement has been developed. The method allowed use of 225Ra, in equilibrium with the parent 229Th, as a yield determinant, and has been applied in 226Ra concentrations measurements in the selected areas of study.U-series progeny, 238U, 234U, 230Th and 226Ra, in totally dissolved sediments fr

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Skains, Rebecca Lyle. "Færwhile & the multimodal creative practice : composing fiction from analogue to digital." Thesis, Bangor University, 2014. https://research.bangor.ac.uk/portal/en/theses/faerwhile--the-multimodal-creative-practice-composing-fiction-from-analogue-to-digital(15d5a8f1-521f-4583-9dc4-a0ef09e1977b).html.

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This practice-led research project explores the influence of digital tools on the composition of narrative. Its purpose was to create a fictional narrative in both analogue (print) and digital forms, observing and analysing the effects of this multimodal composition on the writer's creative practice, and on the resulting narratives. This project thus consists of both the creative artefacts and the critical exegesis that presents the analysis of the creative process and artefacts. The creative artefacts encompass the analogue novella Færwhile, included in this bound thesis as print novella, and

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Bojana, Srećo Zelenović. "Dizajn, sinteza i antiproliferativna aktivnost prirodnih citotoksičnih laktona i analoga." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2013. https://www.cris.uns.ac.rs/record.jsf?recordId=83673&source=NDLTD&language=en.

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Ostvarene su vi&scaron;efazne sinteze prirodnih citotoksičnih laktona (+)-murikatacina (<strong>1</strong>),(–)-murikatacina (ent-<strong>1</strong>) i (+)-goniofufurona (<strong>2</strong>), kao i njihovih novih analoga (<strong>3a</strong>,  <strong>4</strong>,<strong>5</strong>,  <strong>6</strong>,  <strong>7</strong>,  <strong>8</strong>,  <strong>9</strong>,  ent-<strong>7 </strong>i ent-<strong>9</strong>), polazeći iz  D-ksiloze ili iz  D-glukoze. Ispitana je  in vitrocitotoksična aktivnost sintetizovanih prirodnih proizvoda i ana

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46

Goldberg, Jason M. "Signal processing for high resolution pulse width modulation based digital-to-analogue conversion." Thesis, King's College London (University of London), 1992. https://kclpure.kcl.ac.uk/portal/en/theses/signal-processing-for-high-resolution-pulse-width-modulation-based-digitaltoanalogue-conversion(0eb09aa0-1c54-48c3-844f-25aaa98908bf).html.

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47

McEwan, Cameron. "The architecture of analogy : an inquiry into Aldo Rossi's theory of the city, the discipline, the type, and the analogue." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/1a014dcb-9b04-4e26-9559-a95676fa7891.

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The aim of this dissertation is to put forward conceptual frameworks to inquire into and update the following theoretical categories of Aldo Rossi’s architectural production: the city as an artefact, the idea of type, architectural autonomy, history understood as collective imagination, and the concept of the analogical city. On one hand, our inquiry puts forward a close reading of particular aspects of Rossi’s formal and theoretical production, examining Rossi’s work as well as other commentators on Rossi’s work. On the other, the inquiry is supported by a selective reading of major figures a

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U, Seng-Pan. "Tecnicas de interpolacao em filtros multiritmo com condensadores comutados para Interfaces Analogicas com filtragem de alta-frequencia = Multirate Switched-Capacitor interpolation techniques for very high-frequency Analog Front-End filtering." Thesis, University of Macau, 2002. http://umaclib3.umac.mo/record=b1873496.

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Smith, Laura Hayley Susan. "Development of a Pummerer-type cyclisation for the synthesis of analogues of the anti-tumour natural product ecteinascidin 597." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/development-of-a-pummerertype-cyclisation-for-the-synthesis-of-analogues-of-the-antitumour-natural-product-ecteinascidin-597(6efb1fa2-b021-471d-ad12-7953149f8e7d).html.

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A connective Pummerer reaction was developed with a view to its use in the synthesis of analogues of ecteinascidin 597, a member of a family of potent anti-tumour natural products. A one-step synthesis of N-benzyl 2-hydroxyamides, involving the reaction of 2,2-dimethyl-1,3-dioxolan-4-one with amines, was investigated and the products were oxidised to give glyoxamides. Reaction conditions were optimised for the cyclisation of electron-rich N-benzyl glyoxamides in the presence of thiols and a Lewis acid (ZnCl2 or Sc(OTf)3) to give 4-sulfanyltetrahydroisoquinolinones, and mechanistic studies indi

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Robinson, Helena. "The role of nucleotide excision repair in providing resistance to the nucleoside analogue gemcitabine." Thesis, Bangor University, 2017. https://research.bangor.ac.uk/portal/en/theses/the-role-of-nucleotide-excision-repair-in-providing-resistance-to-the-nucleoside-analogue-gemcitabine(5e264d42-33b5-49c7-9106-bef8166cb310).html.

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Gemcitabine is a clinically important chemotherapy drug, used to treat a variety of solid tumours. It is a cytidine analogue and when inserted into DNA in place of cytidine serves to inhibit further chain extension, causing replication stress and ultimately cell death. The nucleotide excision repair (NER) pathway is known to repair a variety of bulky DNA lesions but is not known to have a role mitigating replication stress. However, it was found in a S. pombe screen that mutants lacking homologues of xpa, xpc, xpf and ercc1 showed sensitivity to gemcitabine. Further to this, patient fibroblast

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