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Journal articles on the topic 'Analogues biomimétiques de nicotinamide'

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Published: 25 May 2024

Last updated: 31 July 2025

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1

Lipka, Pawel, Andrzej Zatorski, Kyoichi A. Watanabe, and Krzysztof W. Pankeiwicz. "Synthesis of Methylene-Bridged Analogues of Nicotinamide Riboside, Nicotinamide Mononucleotide and Nicotinamide Adenine Dinucleotide." Nucleosides and Nucleotides 15, no. 1-3 (1996): 149–67. http://dx.doi.org/10.1080/07328319608002377.

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2

Campbell, P. I., M. I. Abraham, and S. A. Kempson. "Increased cAMP in proximal tubules is acute effect of nicotinamide analogues." American Journal of Physiology-Renal Physiology 257, no. 6 (1989): F1021—F1026. http://dx.doi.org/10.1152/ajprenal.1989.257.6.f1021.

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The possible role of adenosine 3',5'-cyclic monophosphate (cAMP) in the mechanism of the acute inhibitory effects of nicotinamide and analogues on brush-border membrane (BBM) phosphate transport was investigated. Compared with basal values, cAMP content of rat renal proximal tubule suspensions was elevated two- to fivefold when incubated at 37 degrees C for 1 h with nicotinamide, 5-methylnicotinamide, or picolinamide at 1–3 mM and in the presence of a phosphodiesterase inhibitor. Thymidine had no effect on cAMP content. There was significant and specific inhibition of BBM transport of phosphat

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3

Pankiewicz, K. W., A. Zatorski, and K. A. Watanabe. "NAD-analogues as potential anticancer agents: conformational restrictions as basis for selectivity." Acta Biochimica Polonica 43, no. 1 (1996): 183–93. http://dx.doi.org/10.18388/abp.1996_4552.

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Cofactor type inhibitors (NAD-analogues) of IMP-dehydrogenase (IMPDH) were synthesized and their application as potential anticancer agents are discussed. C-nucleoside isosteres of NAD, C-NAD and C-PAD, showed an effective competitive inhibition of IMPDH, C-NAD but not C-PAD caused extremely potent inhibition of alcohol dehydrogenase. We also synthesized compounds in which nicotinamide riboside was replaced with tiazofurin (TAD-analogues) and the 2' and 3'-positions of adenosine part were fluorinated. The ribose ring of 2'-deoxy-2'-fluoroadenosine is in the C3'-endo conformation whereas 3'-deo

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4

Pankiewicz, Krzysztof W., Marek M. Kabat, Elzbieta Sochacka, Lech Ciszewski, Joanna Zeidler, and Kyoichi A. Watanabe. "C-Nucleoside Analogues of Nicotinamide Mononucleotide (NMN)." Nucleosides and Nucleotides 7, no. 5-6 (1988): 589–93. http://dx.doi.org/10.1080/07328318808056291.

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5

Goulioukina, Natasha, Johny Wehbe, Damien Marchand, et al. "Synthesis of Nicotinamide Adenine Dinucleotide (NAD) Analogues with a Sugar Modified Nicotinamide Moiety." Helvetica Chimica Acta 90, no. 7 (2007): 1266–78. http://dx.doi.org/10.1002/hlca.200790127.

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6

Migaud, Marie, Philip Redpath, Jolanta Haluszczak, and Simon Macdonald. "Nicotinamide Benzimidazolide Dinucleotides, Non-Cyclisable Analogues of NAD+." Synlett 25, no. 16 (2014): 2331–36. http://dx.doi.org/10.1055/s-0034-1379000.

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7

Hocková, Dana, and Antonín Holý. "Synthesis of Some "Abbreviated" NAD+ Analogues." Collection of Czechoslovak Chemical Communications 62, no. 6 (1997): 948–56. http://dx.doi.org/10.1135/cccc19970948.

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Four new "abbreviated" NAD+ analogues with hydroxymethyl or carboxyl function as a substituent of an aliphatic chain linking the adenine and nicotinamide moieties were prepared using the Zincke reaction as the key step. As intermediates several new acyclic nucleoside analogues containing hydroxy, carboxyl, azido and amino group were prepared.

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8

Matteucci, Federica, Marta Ferrati, Eleonora Spinozzi, et al. "Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes." Pharmaceuticals 17, no. 6 (2024): 739. http://dx.doi.org/10.3390/ph17060739.

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Nicotinamide adenine dinucleotide (NAD) cofactor metabolism plays a significant role in cancer development. Tumor cells have an increased demand for NAD and ATP to support rapid growth and proliferation. Limiting the amount of available NAD by targeting critical NAD biosynthesis enzymes has emerged as a promising anticancer therapeutic approach. In mammals, the enzyme nicotinamide/nicotinic acid adenylyltransferase (NMNAT) catalyzes a crucial downstream reaction for all known NAD synthesis routes. Novel nicotinamide/nicotinic acid adenine dinucleotide (NAD/NaAD) analogues 1–4, containing a met

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9

Röllig, Robert, Caroline E. Paul, Magalie Claeys-Bruno, Katia Duquesne, Selin Kara, and Véronique Alphand. "Divorce in the two-component BVMO family: the single oxygenase for enantioselective chemo-enzymatic Baeyer–Villiger oxidations." Organic & Biomolecular Chemistry 19, no. 15 (2021): 3441–50. http://dx.doi.org/10.1039/d1ob00015b.

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10

Kongmuang, Somlak. "Hydrotropic Solubilization of Riboflavin by Urea, Nicotinamide and Nicotinamide Analogues in Aqueous Systems(การละลายในนํ้าฃองไรโบฟลาวินโดยสารไฮโดรโทรปิค: ยูเ..." Thai Journal of Pharmaceutical Sciences 26, № 1 (2002): 61–68. http://dx.doi.org/10.56808/3027-7922.2288.

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11

Hocková, Dana, Milena Masojídková, and Antonín Holý. ""Abbreviated" NAD+ Analogues Containinga Phosphonate Function." Collection of Czechoslovak Chemical Communications 61, no. 10 (1996): 1538–48. http://dx.doi.org/10.1135/cccc19961538.

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"Abbreviated" NAD+ analogues with anionic phosphonate function as a part of the link between the adenine and nicotinamide moieties, 9-(2-phosphonomethoxyethyl)adenine 2-(3-carbamoylpyridinium)ethyl ester (1a), (R)- and (S)-9-(2-phosphonomethoxypropyl)adenine 2-(3-carbamoylpyridinium)ethyl ester (1b and 1c), (RS)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine 2-(3-carbamoylpyridinium)ethyl ester (1d), and (S)- and (R)-1-[3-(adenin-9-yl)-2-phosphonatomethoxypropyl]-3-carbamoylpyridinium (2a and 2b), were prepared by multistep syntheses using the Zincke reaction in the last step.

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12

Pankiewicz, Krzysztof, Kyoichi Watanabe, Krystyna Lesiak-Watanabe, Barry Goldstein, and Hiremagalur Jayaram. "The Chemistry of Nicotinamide Adenine Dinucleotide (NAD) Analogues Containing C-Nucleosides Related to Nicotinamide Riboside [1]." Current Medicinal Chemistry 9, no. 7 (2002): 733–41. http://dx.doi.org/10.2174/0929867024606920.

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13

Petrelli, Riccardo, Yuk Yin Sham, Liqiang Chen, et al. "Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues." Bioorganic & Medicinal Chemistry 17, no. 15 (2009): 5656–64. http://dx.doi.org/10.1016/j.bmc.2009.06.013.

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14

Pankiewicz, K. W., K. Malinowski, H. N. Jayaram, K. Lesiak Watanabe, and K. A. Watanabe. "Novel Mycophenolic Adenine Bis{phosphonate)s as Potential Immunosuppressants." Current Medicinal Chemistry 6, no. 7 (1999): 629–34. http://dx.doi.org/10.2174/092986730607220401124820.

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Abstracts: Mycophenolic acid (MPA) is the most potent and specific inhibitor of inosine monophosphate dehydrogenase (IMPDH). This compound was reported to bind the NAD site of IMPDH and mimic the binding of nicotinamide moiety of nicotinamide adenine dinucleotide. We linked MPA derivatives with the adenine moiety of NAD through a methylenebis(phosphonate) bridge to form novel mycophenolic adenine dinucleotides (MADs) which resemble well the intact natural cofactor. The MAD analogues differ by the length of the side chain (linker) between the aromatic ring of mycophenolic derivative and the -ph

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15

Sicsic, Sames, Mohamed Ikbal, and François Le Goffic. "Chemoenzymatic approach to carbocyclic analogues of ribonucleosides and nicotinamide ribose." Tetrahedron Letters 28, no. 17 (1987): 1887–88. http://dx.doi.org/10.1016/s0040-4039(00)96001-5.

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16

Tanimori, Shinji, Takeshi Ohta, and Mitsunori Kirihata. "An efficient chemical synthesis of nicotinamide riboside (NAR) and analogues." Bioorganic & Medicinal Chemistry Letters 12, no. 8 (2002): 1135–37. http://dx.doi.org/10.1016/s0960-894x(02)00125-7.

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17

Paul, Caroline E., Isabel W. C. E. Arends, and Frank Hollmann. "Is Simpler Better? Synthetic Nicotinamide Cofactor Analogues for Redox Chemistry." ACS Catalysis 4, no. 3 (2014): 788–97. http://dx.doi.org/10.1021/cs4011056.

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18

Makarov, Mikhail V., та Marie E. Migaud. "Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives". Beilstein Journal of Organic Chemistry 15 (13 лютого 2019): 401–30. http://dx.doi.org/10.3762/bjoc.15.36.

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The β-anomeric form of nicotinamide riboside (NR+) is a precursor for nicotinamide adenine dinucleotide (NAD+), a redox cofactor playing a critical role in cell metabolism. Recently, it has been demonstrated that its chloride salt (NR+Cl−) has beneficial effects, and now NR+Cl−is available as a dietary supplement. Syntheses and studies of analogues and derivatives of NR+are of high importance to unravel the role of NR+in biochemical processes in living cells and to elaborate the next generation of NR+derivatives and conjugates with the view of developing novel drug and food supplement candidat

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19

Arora, Mandeep Kumar, Parul Grover, Syed Mohammed Basheeruddin Asdaq, et al. "Potential role of nicotinamide analogues against SARS-COV-2 target proteins." Saudi Journal of Biological Sciences 28, no. 12 (2021): 7567–74. http://dx.doi.org/10.1016/j.sjbs.2021.09.072.

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20

Larocque, Elizabeth, Elizabeth Fei Yin Chu, Nimmashetti Naganna, and Herman O. Sintim. "Nicotinamide–Ponatinib Analogues as Potent Anti-CML and Anti-AML Compounds." ACS Omega 5, no. 6 (2020): 2690–98. http://dx.doi.org/10.1021/acsomega.9b03223.

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21

Lee, H. J., and G. G. Chang. "Interactions of nicotinamide-adenine dinucleotide phosphate analogues and fragments with pigeon liver malic enzyme. Synergistic effect between the nicotinamide and adenine moieties." Biochemical Journal 245, no. 2 (1987): 407–14. http://dx.doi.org/10.1042/bj2450407.

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The structural requirements of the NADP+ molecule as a coenzyme in the oxidative decarboxylation reaction catalysed by pigeon liver malic enzyme were studied by kinetic and fluorimetric analyses with various NADP+ analogues and fragments. The substrate L-malate had little effect on the nucleotide binding. Etheno-NADP+, 3-acetylpyridine-adenine dinucleotide phosphate, and nicotinamide-hypoxanthine dinucleotide phosphate act as alternative coenzymes for the enzyme. Their kinetic parameters were similar to that of NADP+. Thionicotinamide-adenine dinucleotide phosphate, 3-aminopyridine-adenine din

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22

Nashawi, Asma A., and Richard Hartley. "New Vitamin E Analogues." Journal of King Abdulaziz University - Medical Sciences 23, no. 4 (2016): 25–42. http://dx.doi.org/10.4197/med.23-4.4.

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Lipid peroxidation is the mediator of several pathophysiological events such atherosclerosis, neurodegenerative disease and others. It is induced by reactive oxygen species that react with biological substrates, leading to cell damage. It is thought that Nicotinamide Adenine Dinucleotide Phosphate Hydrogen oxidases, as well as mitochondria dysfunction and other sources, are at the centre of these events, so it becomes an important therapeutic target. In order to retard this damage and the progression of the disease, the natural and synthetic antioxidant vitamin E (Tocopherol) has been studied

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23

Brown, J. M., M. J. Lemmon, M. R. Horsman, and W. W. Lee. "Structure–activity Relationships for Tumour Radiosensitization by Analogues of Nicotinamide and Benzamide." International Journal of Radiation Biology 59, no. 3 (1991): 739–48. http://dx.doi.org/10.1080/09553009114550651.

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24

Hargenrader, George N., Ravindra B. Weerasooriya, Stefan Ilic, Jens Niklas, Oleg G. Poluektov, and Ksenija D. Glusac. "Photoregeneration of Biomimetic Nicotinamide Adenine Dinucleotide Analogues via a Dye-Sensitized Approach." ACS Applied Energy Materials 2, no. 1 (2018): 80–91. http://dx.doi.org/10.1021/acsaem.8b01574.

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25

Batoux, Nathalie E., Francesca Paradisi, Paul C. Engel, and Marie E. Migaud. "Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD+-dependent enzymes." Tetrahedron 60, no. 31 (2004): 6609–17. http://dx.doi.org/10.1016/j.tet.2004.05.091.

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26

Paul, Caroline E., Isabel W. C. E. Arends, and Frank Hollmann. "ChemInform Abstract: Is Simpler Better? Synthetic Nicotinamide Cofactor Analogues for Redox Chemistry." ChemInform 45, no. 18 (2014): no. http://dx.doi.org/10.1002/chin.201418274.

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27

KROHN, K., H. HEINS, and K. WIELCKENS. "ChemInform Abstract: Synthesis and Cytotoxic Activity of C-Glycosidic Nicotinamide Riboside Analogues." ChemInform 23, no. 23 (2010): no. http://dx.doi.org/10.1002/chin.199223265.

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28

Tanimori, Shinji, Takeshi Ohta, and Mitsunori Kirihata. "ChemInform Abstract: An Efficient Chemical Synthesis of Nicotinamide Riboside (NAR) and Analogues." ChemInform 33, no. 33 (2010): no. http://dx.doi.org/10.1002/chin.200233231.

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29

Bezsudnova, Ekaterina Yu, Tatiana E. Petrova, Natalia V. Artemova, et al. "NADP-Dependent Aldehyde Dehydrogenase from Archaeon Pyrobaculum sp.1860: Structural and Functional Features." Archaea 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/9127857.

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We present the functional and structural characterization of the first archaeal thermostable NADP-dependent aldehyde dehydrogenase AlDHPyr1147. In vitro, AlDHPyr1147 catalyzes the irreversible oxidation of short aliphatic aldehydes at 60–85°С, and the affinity of AlDHPyr1147 to the NADP+ at 60°С is comparable to that for mesophilic analogues at 25°С. We determined the structures of the apo form of AlDHPyr1147 (3.04 Å resolution), three binary complexes with the coenzyme (1.90, 2.06, and 2.19 Å), and the ternary complex with the coenzyme and isobutyraldehyde as a substrate (2.66 Å). The nicotin

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30

Kolbin, A. S., A. A. Kurylev, Yu Ye Balykina, M. A. Proskurin, and S. A. Mishinova. "Pharmacoeconomic analysis of insulin aspart+nicotinamide versus insulin aspart in patients with diabetes mellitus." Pharmacoeconomics: theory and practice 9, no. 4 (2021): 5–11. http://dx.doi.org/10.30809/phe.4.2021.1.

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Glycemic control is a clinical goal in the treatment of diabetes mellitus. Currently available bolus insulin analogues do not follow the physiological pattern of insulin secretion after meals because they are slowly absorbed from the injection site. Insulin aspart+nicotinamide is an ultra-fast acting human insulin analog that can be administered before or after meals and the nicotinamide (vitamin B3) molecule provides optimal glycemic control. Aim. To evaluate clinical and economic efficacy of the drug insulin aspart+nicotinamide in comparison with insulin aspart in patients with diabetes mell

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31

Chen, Dongxing, Linjie Li, Krystal Diaz, et al. "Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N-Methyltransferase." Journal of Medicinal Chemistry 62, no. 23 (2019): 10783–97. http://dx.doi.org/10.1021/acs.jmedchem.9b01255.

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32

WALL, Katherine A., Mariola KLIS, John KORNET, et al. "Inhibition of the intrinsic NAD+ glycohydrolase activity of CD38 by carbocyclic NAD analogues." Biochemical Journal 335, no. 3 (1998): 631–36. http://dx.doi.org/10.1042/bj3350631.

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Carba-NAD and pseudocarba-NAD are carbocyclic analogues of NAD+ in which a 2,3-dihydroxycyclopentane methanol replaces the β-d-ribonucleotide ring of the nicotinamide riboside moiety of NAD+ [Slama and Simmons (1988) Biochemistry 27, 183–193]. These carbocyclic NAD+ analogues, related to each other as diastereomers, have been tested as inhibitors of the intrinsic NAD+ glycohydrolase activity of human CD38, dog spleen NAD+ glycohydrolase, mouse CD38 and Aplysia californicacADP-ribose synthetase. Pseudocarba-NAD, the carbocyclic dinucleotide in which l-2,3-dihydroxycyclopentane methanol replaces

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33

Pankiewicz, Krzysztof W., and Krzysztof Felczak. "From ribavirin to NAD analogues and back to ribavirin in search for anticancer agents." Heterocyclic Communications 21, no. 5 (2015): 249–57. http://dx.doi.org/10.1515/hc-2015-0133.

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AbstractRibavirin, a broad-spectrum antiviral agent is used in the clinic alone or in combination with other antivirals and/or interferons. Numerous structural analogues of ribavirin have been developed, among them tiazofurin, which is inactive against viruses but is a potent anticancer drug. Tiazofurin was found to inhibit nicotinamide adenine dinucleotide (NAD)-dependent inosine monophosphate dehydrogenase (IMPDH) after metabolic conversion into tiazofurin adenine dinucleotide (TAD), which binds well but could not serve as IMPDH cofactor. TAD showed high selectivity against human IMPDH vs. o

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34

Nayak, Yogendra, Venkatachalam Hillemane, Vijay Kumar Daroji, B. S. Jayashree, and M. K. Unnikrishnan. "Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats." Scientific World Journal 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/854267.

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Benzopyrones are proven antidiabetic drug candidate in diabetic drug discovery. In this view novel synthetic benzopyrone analogues were selected for testing in experimental diabetes. Type 2 diabetes (T2D) was induced in Wistar rats by streptozotocin (60 mg/kg, i.p.) followed by nicotinamide (120 mg/kg i.p.). Rats having fasting blood glucose (FBG) >200 mg/dL, 7 days after T2D-induction, are selected for the study. Test compounds and standard treatment were continued for 15 days. FBG, oral glucose tolerance test (OGTT), and insulin tolerance test (ITT) were determined on 21st day after induc

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35

Wang, Lei, Bin Liu, Yuxue Liu, et al. "Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues." Organic Letters 21, no. 9 (2019): 3218–22. http://dx.doi.org/10.1021/acs.orglett.9b00935.

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36

Kam, Bernard L., Olaf Malver, Thomas M. Marschner, and Norman J. Oppenheimer. "Pyridine coenzyme analogues. Synthesis and characterization of .alpha.- and .beta.-nicotinamide arabinoside adenine dinucleotides." Biochemistry 26, no. 12 (1987): 3453–61. http://dx.doi.org/10.1021/bi00386a031.

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37

ZIEGLER, Mathias, Dierk JORCKE, and Manfred SCHWEIGER. "Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase." Biochemical Journal 326, no. 2 (1997): 401–5. http://dx.doi.org/10.1042/bj3260401.

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The present investigation identifies bovine liver mitochondrial NADase (NAD+ glycohydrolase) as a member of the class of bifunctional ADP-ribosyl cyclases/cyclic ADP-ribose hydrolases, known to be potential second messenger enzymes. These enzymes catalyse the synthesis and degradation of cyclic ADP-ribose, a potent intracellular calcium-mobilizing agent. The mitochondrial enzyme utilized the NAD+ analogues nicotinamide guanine dinucleotide (NGD+) and nicotinamide hypoxanthine dinucleotide (NHD+) to form fluorescent cyclic purine nucleoside diphosphoriboses. ADP-ribosyl cyclase activity was als

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38

SLEATH, P. R., A. L. HANDLON, and N. J. OPPENHEIMER. "ChemInform Abstract: Pyridine Coenzyme Analogues. Part 3. Synthesis of Three NAD+ Analogues Containing a 2′-Deoxy-2′-Substituted Nicotinamide Arabinofuranosyl Moiety." ChemInform 22, no. 41 (2010): no. http://dx.doi.org/10.1002/chin.199141250.

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39

OHTA, Tatuya, Syuhei ISHIKURA, Syunichi SHINTANI, Noriyuki USAMI та Akira HARA. "Kinetic alteration of a human dihydrodiol/3α-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine". Biochemical Journal 352, № 3 (2000): 685–91. http://dx.doi.org/10.1042/bj3520685.

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Human dihydrodiol dehydrogenase with 3α-hydroxysteroid dehydrogenase activity exists in four forms (AKR1C1Ő1C4) that belong to the aldoŐketo reductase (AKR) family. Recent crystallographic studies on the other proteins in this family have indicated a role for a tyrosine residue (corresponding to position 216 in these isoenzymes) in stacking the nicotinamide ring of the coenzyme. This tyrosine residue is conserved in most AKR family members including AKR1C1Ő1C3, but is replaced with histidine in AKR1C4 and phenylalanine in some AKR members. In the present study we prepared mutant enzymes of AKR

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40

Galloway, T. S., and S. van Heyningen. "Binding of NAD+ by cholera toxin." Biochemical Journal 244, no. 1 (1987): 225–30. http://dx.doi.org/10.1042/bj2440225.

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1. The Km for NAD+ of cholera toxin working as an NAD+ glycohydrolase is 4 mM, and this is increased to about 50 mM in the presence of low-Mr ADP-ribose acceptors. Only molecules having both the adenine and nicotinamide moieties of NAD+ with minor alterations in the nicotinamide ring can be competitive inhibitors of this reaction. 2. This high Km for NAD+ is also reflected in the dissociation constant, Kd, which was determined by a variety of methods. 3. Results from equilibrium dialysis were subject to high error, but showed one binding site and a Kd of about 3 mM. 4. The A1 peptide of the to

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41

Conforti, Irene, Andrea Benzi, Irene Caffa, Santina Bruzzone, Alessio Nencioni, and Alberto Marra. "Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents." Pharmaceutics 15, no. 5 (2023): 1472. http://dx.doi.org/10.3390/pharmaceutics15051472.

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The nicotinamide phosphoribosyltransferase (NAMPT) is considered a very promising therapeutic target because it is overexpressed in pancreatic cancer. Although many inhibitors have been prepared and tested, clinical trials have shown that NAMPT inhibition may result in severe haematological toxicity. Therefore, the development of conceptually new inhibitors is an important and challenging task. We synthesized ten β-d-iminoribofuranosides bearing various heterocycle-based chains carbon-linked to the anomeric position starting from non-carbohydrate derivatives. They were then submitted to NAMPT

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42

Felczak, Krzysztof, and Krzysztof W. Pankiewicz. "Synthesis of Methylenebis(Phosphonate) Analogues of 2-, 4-, and 6-Pyridones of Nicotinamide Adenine Dinucleotide." Nucleosides, Nucleotides and Nucleic Acids 30, no. 7-8 (2011): 512–23. http://dx.doi.org/10.1080/15257770.2011.575909.

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43

Tanuma, Sei-ichi, Kiyotaka Katsuragi, Takahiro Oyama, et al. "Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors." Molecules 25, no. 16 (2020): 3633. http://dx.doi.org/10.3390/molecules25163633.

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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is an attractive therapeutic strategy for targeting cancer metabolism. So far, many potent NAMPT inhibitors have been developed and shown to bind to two unique tunnel-shaped cavities existing adjacent to each active site of a NAMPT homodimer. However, cytotoxicities and resistances to NAMPT inhibitors have become apparent. Therefore, there remains an urgent need to develop effective and safe NAMPT inhibitors. Thus, we designed and synthesized two close structural analogues of NAMPT inhibitors, azaindole–piperidine (3a)- and azaindole

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44

Zhang, Liangren, Anna Ka Yee Kwong, Zhenjun Yang, Zhe Chen, Hon Cheung Lee, and Lihe Zhang. "Studies on the Synthesis of Nicotinamide Nucleoside and Nucleotide Analogues and Their Inhibitions towards CD38 NADase." HETEROCYCLES 83, no. 12 (2011): 2837. http://dx.doi.org/10.3987/com-11-12361.

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45

Galloway, T. S., R. M. Tait, and S. van Heyningen. "Photolabelling of cholera toxin by NAD+." Biochemical Journal 242, no. 3 (1987): 927–30. http://dx.doi.org/10.1042/bj2420927.

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When cholera toxin is incubated under u.v. light with NAD+ labelled in either the adenine or the nicotinamide moiety, radioactivity becomes covalently bound to the protein. The reaction is specific for cholera toxin, and is inhibited by excess unlabelled NAD+ or NAD analogues. Only the active A 1 chain of the toxin is labelled. The u.v.-absorption spectrum of the product is very similar to that of NAD+, and shows the same reaction with cyanide. The nature of the product is therefore different from that found when diphtheria toxin is photolabelled [Carroll & Collier (1984) Proc. Natl. Acad.

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Czarnecka, Kamila, Małgorzata Girek, Paweł Kręcisz, et al. "Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease." International Journal of Molecular Sciences 20, no. 3 (2019): 498. http://dx.doi.org/10.3390/ijms20030498.

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Here we report the two-step synthesis of 8 new cyclopentaquinoline derivatives as modifications of the tetrahydroacridine structure. Next, the biological assessment of each of them was performed. Based on the obtained results we identified 6-chloro-N-[2-(2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamino)-hexyl]]-nicotinamide hydrochloride (3e) as the most promising compound with inhibitory potencies against EeAChE and EqBuChE in the low nanomolar level 67 and 153 nM, respectively. Moreover, 3e compound is non-hepatotoxic, able to inhibit amyloid beta aggregation, and shows a mix-type of cholinest

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Whyte, B. J., and W. T. Griffiths. "8-vinyl reduction and chlorophyll a biosynthesis in higher plants." Biochemical Journal 291, no. 3 (1993): 939–44. http://dx.doi.org/10.1042/bj2910939.

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A technique involving solid-phase extractions and polyethylene h.p.l.c. suitable for the routine compositional analysis of the total protochlorophyllide pool of plants is described. The resynthesis kinetics of the individual components of the pool have been studied in briefly illuminated etiolated tissue of wheat (Triticum aestivum) and cucumber (Cucumis sativus) during subsequent redarkening. The data are interpreted in terms of a precursor-product relationship between the di- and mono-vinyl analogues of protochlorophyllide during their reaccumulation in darkness. The interconversion is assum

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Jiang, Jie, Hongjun Kang, Xiaoliang Song, Sichao Huang, Sha Li, and Jun Xu. "A Model of Interaction between Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Apocynin Analogues by Docking Method." International Journal of Molecular Sciences 14, no. 1 (2013): 807–17. http://dx.doi.org/10.3390/ijms14010807.

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Pankiewicz, Krzysztof W. "Novel nicotinamide adenine dinucleotide analogues as potential anticancer agents: Quest for specific inhibition of inosine monophosphate dehydrogenase." Pharmacology & Therapeutics 76, no. 1-3 (1997): 89–100. http://dx.doi.org/10.1016/s0163-7258(97)00092-2.

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Chen, Zhe, Anna Ka Yee Kwong, Zhenjun Yang, Liangren Zhang, Hon Cheung Lee, and Lihe Zhang. "ChemInform Abstract: Studies of the Synthesis of Nicotinamide Nucleoside and Nucleotide Analogues and Their Inhibitions Towards CD38 NADase." ChemInform 43, no. 15 (2012): no. http://dx.doi.org/10.1002/chin.201215205.

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