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1

BOURDREZ, Valentine, and Sghaier CHRIKI. "Qualités nutritionnelle, organoleptique et disposition à payer pour les alternatives à la viande : cas des analogues végétaux, de la « viande in vitro » et des insectes." INRAE Productions Animales 35, no. 3 (2022): 217–36. http://dx.doi.org/10.20870/productions-animales.2022.35.3.7265.

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 Développer les alternatives à la viande est présenté comme une solution pour renforcer la durabilité de l’alimentation tout en apportant des sources de nutriments indispensables (protéines, micronutriments…), notamment pour des régimes végétariens, végans voire flexitariens. Cela peut aussi permettre une diversification du marché de l’agroalimentaire par une plus grande offre de produits aux consommateurs. Mais d’un point de vue nutritionnel, la digestibilité de certains nutriments reste mal connue, et les process pour reproduire les mêmes qualités organoleptiques que la viande sont en
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HOCQUETTE, J. F., P. MAINSANT, J. D. DAUDIN, et al. "La viande du futur sera-t-elle produite in vitro ?" INRAE Productions Animales 26, no. 4 (2013): 363–74. http://dx.doi.org/10.20870/productions-animales.2013.26.4.3164.

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La production de viande artificielle par culture de cellules est proposée par certains scientifiques comme une des solutions pour répondre aux grands enjeux de l’élevage : i) réduire le mal-être supposé des animaux dans les élevages modernes, voire ne pas tuer les animaux pour les manger, ii) réduire la possible dégradation de l’environnement par l’élevage et iii) réduire la faim dans le monde en augmentant le niveau des ressources protéiques alimentaires. La viande artificielle supprimerait en effet le mal-être supposé des animaux lié à l’élevage et permettrait de ne pas abattre les animaux p
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3

Muller, K., T. Pomorski, P. Muller, and A. Herrmann. "Stability of transbilayer phospholipid asymmetry in viable ram sperm cells after cryotreatment." Journal of Cell Science 112, no. 1 (1999): 11–20. http://dx.doi.org/10.1242/jcs.112.1.11.

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The transbilayer dynamics of lipids in the plasma membrane of mammalian sperm cells is crucial for the fertilization process. Here, the transbilayer movement and distribution of phospholipids in the plasma membrane of fresh, ejaculated and cryopreserved ram spermatozoa was studied by labeling cells with fluorescent analogues of phosphatidylserine and phosphatidylcholine. By co-labeling cells with the DNA-binding dye propidiumiodide as well as by employing fluorescence microscopy and flow cytometry we were able to determine the transbilayer redistribution of fluorescent phospholipid analogues i
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4

Handayani, Noer Abyor, Siswo Sumardiono, Aprilina Purbasari, Alfan Fatir Fatikah, and Imam Muda Alhakim. "Physicochemical Properties of Sago- and Corn Flour-Based Rice Analogues Fortified with Black-Eyed Bean Flour and Skimmed Milk Powder." Food Technology and Biotechnology 62, no. 4 (2024): 501–11. https://doi.org/10.17113/ftb.62.04.24.8357.

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Research background. With the increasing consumption of food commodities, particularly rice, and the substantial volume of food imports in Indonesia, there is an increasing need to explore alternative food sources. Rice analogues emerge as a potential substitute for traditional rice, serving as a viable staple food option. The aim of this study is to investigate the effect of the composition of raw material, namely sago and corn flour, on the physicochemical properties and consumer acceptance of rice analogues. Experimental approach. The rice analogues were produced using the hot extrusion met
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5

Zhang, Baole, Luping Pang, Manesh Nautiyal, et al. "Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors." Molecules 25, no. 20 (2020): 4751. http://dx.doi.org/10.3390/molecules25204751.

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Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to the purine-like 7-amino-5-hydroxymethylbenzimidazole nucleoside analogue following an optimized synthetic pathway. These compounds were designed as aaRS inhibitors and can be considered as 1,3-dideazaadenine analogues carrying a 2-hydroxymethyl substituent. Despite our intentions to obtain N1-glycosylated 4-aminobenzimidazole congeners, resembling the natural purine nucleosides glycosylated at the
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Aoi, Yuki, Shigehiro A. Kawashima, Viesturs Simanis, Masayuki Yamamoto, and Masamitsu Sato. "Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis." Open Biology 4, no. 7 (2014): 140063. http://dx.doi.org/10.1098/rsob.140063.

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Analogue-sensitive (as) mutants of kinases are widely used to selectively inhibit a single kinase with few off-target effects. The analogue-sensitive mutant cdc2-as of fission yeast ( Schizosaccharomyces pombe ) is a powerful tool to study the cell cycle, but the strain displays meiotic defects, and is sensitive to high and low temperature even in the absence of ATP-analogue inhibitors. This has limited the use of the strain for use in these settings. Here, we used in vivo selection for intragenic suppressor mutations of cdc2-as that restore full function in the absence of ATP-analogues. The c
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7

Choudhury, Sujata Maiti, Malaya Gupta, and Upal Kanti Majumder. "Antineoplastic Activities of MT81 and Its Structural Analogue in Ehrlich Ascites Carcinoma-Bearing Swiss Albino Mice." Oxidative Medicine and Cellular Longevity 3, no. 1 (2010): 61–70. http://dx.doi.org/10.4161/oxim.3.1.10495.

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Many fungal toxins exhibit in vitro and in vivo antineoplastic effects on various cancer cell types. Luteoskyrin, a hydroxyanthraquinone has been proved to be a potent inhibitor against Ehrlich ascites tumor cells. The comparative antitumor activity and antioxidant status of MT81 and its structural analogue [Acetic acid-MT81 (Aa-MT81)] having polyhydroxyanthraquinone structure were assessed against Ehrlich ascites carcinoma (EAC ) tumor in mice. The in vitro cytotoxicity was measured by the viability of EAC cells after direct treatment of the said compounds. In in vivo study, MT81 and its stru
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8

Nam, Ki Yoon, Kongara Damodar, Yeontaek Lee та ін. "Design and Synthesis of π-Extended Resveratrol Analogues and In Vitro Antioxidant and Anti-Inflammatory Activity Evaluation". Molecules 26, № 3 (2021): 646. http://dx.doi.org/10.3390/molecules26030646.

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The research on resveratrol (1) has been conducted intensively over a long time due to its proven antioxidant activity and disease-fighting capabilities. Many efforts have also been made to increase these biological effects. In the present study, six new extended aromatic resveratrol analogues containing naphthalene (2) and its bioisosteres quinoline (3 and 4), isoquinoline (5) quinoxaline (6) and quinazoline (7) scaffolds were designed and synthesized using an annulation strategy. The antioxidant and anti-inflammatory activities of these compounds were investigated. All compounds showed bette
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9

Iliev, Stoyan, Gergana Gocheva, Nikoleta Ivanova, et al. "Identification and computational characterization of isomers with cis and trans amide bonds in folate and its analogues." Physical Chemistry Chemical Physics 20, no. 45 (2018): 28818–31. http://dx.doi.org/10.1039/c8cp04304c.

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10

Oliver, James A. W., Matthew Kelbrick, Nisha K. Ramkissoon, et al. "Sulfur Cycling as a Viable Metabolism under Simulated Noachian/Hesperian Chemistries." Life 12, no. 4 (2022): 523. http://dx.doi.org/10.3390/life12040523.

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Water present on the surface of early Mars (>3.0 Ga) may have been habitable. Characterising analogue environments and investigating the aspects of their microbiome best suited for growth under simulated martian chemical conditions is key to understanding potential habitability. Experiments were conducted to investigate the viability of microbes from a Mars analogue environment, Colour Peak Springs (Axel Heiberg Island, Canadian High Arctic), under simulated martian chemistries. The fluid was designed to emulate waters thought to be typical of the late Noachian, in combination with regolith
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Pua, Aileen, Vivien Chia Yen Tang, Rui Min Vivian Goh, Jingcan Sun, Benjamin Lassabliere, and Shao Quan Liu. "Ingredients, Processing, and Fermentation: Addressing the Organoleptic Boundaries of Plant-Based Dairy Analogues." Foods 11, no. 6 (2022): 875. http://dx.doi.org/10.3390/foods11060875.

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Consumer interest and research in plant-based dairy analogues has been growing in recent years because of increasingly negative implications of animal-derived products on human health, animal wellbeing, and the environment. However, plant-based dairy analogues face many challenges in mimicking the organoleptic properties of dairy products due to their undesirable off-flavours and textures. This article thus reviews fermentation as a viable pathway to developing clean-label plant-based dairy analogues with satisfactory consumer acceptability. Discussions on complementary strategies such as raw
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Prabhu, Gurpur Rakesh D., Henryk A. Witek, and Pawel L. Urban. "Chemical clocks, oscillations, and other temporal effects in analytical chemistry: oddity or viable approach?" Analyst 143, no. 15 (2018): 3514–25. http://dx.doi.org/10.1039/c7an01926b.

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Carruthers, Lenny M., Laurence J. Marton, and Craig L. Peterson. "Polyamine analogues: potent inducers of nucleosomal array oligomerization and inhibitors of yeast cell growth." Biochemical Journal 405, no. 3 (2007): 541–45. http://dx.doi.org/10.1042/bj20061347.

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Polyamines are naturally occurring intracellular polycations that are essential for viability and growth of eukaryotes. Dysregulation of polyamine metabolism is a hallmark of cancer and the carcinogenic process, and consequently development of polyamine analogues has emerged as a viable strategy for therapeutic intervention. Previously, we showed that the naturally occurring polyamines spermidine and spermine were quite effective at inducing the oligomerization of nucleosomal arrays in vitro, suggesting that polyamines may play a key role in regulating higher order chromatin structures in vivo
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Wallace, H. M., and A. V. Fraser. "Polyamine analogues as anticancer drugs." Biochemical Society Transactions 31, no. 2 (2003): 393–96. http://dx.doi.org/10.1042/bst0310393.

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Just over 30 years ago, the late Diane Russell published the first in a series of papers linking polyamines and cancer. These early studies led to a flurry of research activity in the polyamine field that continues to this day attempting to identify a role for the polyamines in cancer development, treatment and/or prevention. The recognition that polyamines are critical for the growth of cancer cells, and consequently the identification of their metabolic pathways as a target for therapeutic intervention, led to the development of a number of useful inhibitors of polyamine biosynthesis. Arguab
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15

Slabin, Uladzimir. "PRODUCTIVE METAPHOR OF MOLECULAR ORBITALS IN EDUCATION AND ANY VIABLE THEORY." Journal of Baltic Science Education 21, no. 1 (2022): 4–6. http://dx.doi.org/10.33225/jbse/22.21.04.

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A lot has been researched on and published about applying analogies in teaching science. The content being complex, often abstract, and difficult for understanding, analogy comes as an effective tool to catch the essence. In brief, using an analogy for explanation of something unfamiliar new, we take something familiar old and establish connections between the two (Sarantopoulous & Tsaparlis, 2004).
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16

Cultrara, Nicholas D., Maxx Q. Arguilla, Shishi Jiang, et al. "Group-13 and group-15 doping of germanane." Beilstein Journal of Nanotechnology 8 (August 9, 2017): 1642–48. http://dx.doi.org/10.3762/bjnano.8.164.

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Germanane, a hydrogen-terminated graphane analogue of germanium has generated interest as a potential 2D electronic material. However, the incorporation and retention of extrinsic dopant atoms in the lattice, to tune the electronic properties, remains a significant challenge. Here, we show that the group-13 element Ga and the group-15 element As, can be successfully doped into a precursor CaGe2 phase, and remain intact in the lattice after the topotactic deintercalation, using HCl, to form GeH. After deintercalation, a maximum of 1.1% As and 2.3% Ga can be substituted into the germanium lattic
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17

Beaver, Rachel C., Katja Engel, W. Jeffrey Binns, and Josh D. Neufeld. "Microbiology of barrier component analogues of a deep geological repository." Canadian Journal of Microbiology 68, no. 2 (2022): 73–90. http://dx.doi.org/10.1139/cjm-2021-0225.

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Canada is currently implementing a site selection process to identify a location for a deep geological repository (DGR) for the long-term storage of Canada’s used nuclear fuel, wherein used nuclear fuel bundles will be sealed inside copper-coated carbon steel containers, encased in highly compacted bentonite clay buffer boxes, and sealed deep underground in a stable geosphere. Because a DGR must remain functional for a million years, it is important to examine ancient natural systems that serve as analogues for planned DGR components. Specifically, studying the microbiology of natural analogue
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Gejalakshmi, S., and N. Harikrishnan. "Molecular Docking Study of Quercetein Analogues for Treating Tumours." International Journal of PharmTech Research 12, no. 4 (2019): 30–34. http://dx.doi.org/10.20902/ijptr.2019.120405.

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Drug discovery leading to robust and viable lead candidate’s remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. The present research attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach comm
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19

Biswas, Subhankar, Neetinkumar D. Reddy, B. S. Jayashree, and C. Mallikarjuna Rao. "Evaluation of Novel 3-Hydroxyflavone Analogues as HDAC Inhibitors against Colorectal Cancer." Advances in Pharmacological Sciences 2018 (December 27, 2018): 1–14. http://dx.doi.org/10.1155/2018/4751806.

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Alteration of epigenetic enzymes is associated with the pathophysiology of colon cancer with an overexpression of histone deacetylase 8 (HDAC8) enzyme in this tissue. Numerous reports suggest that targeting HDAC8 is a viable strategy for developing new anticancer drugs. Flavonols provide a rich source of molecules that are effective against cancer; however, their clinical use is limited. The present study investigated the potential of quercetin and synthetic 3-hydroxyflavone analogues to inhibit HDAC8 enzyme and evaluated their anticancer property. Synthesis of the analogues was carried out, a
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Tandon, Saira S., Iffath Hoskins, and Salman Azhar. "Intrathecal baclofen pump – a viable therapeutic option in pregnancy." Obstetric Medicine 3, no. 3 (2010): 119–20. http://dx.doi.org/10.1258/om.2010.100016.

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Baclofen, a gamma-aminobutyric acid analogue, is used as a muscle relaxant and antispasmodic to relieve symptoms in patients with intractable spasticity arising from cerebral or spinal aetiology such as in traumatic brain injury or multiple sclerosis. As it is often used in women of reproductive age, it is imperative to know the safety and associated maternal and fetal risks. The Food and Drug Administration has assigned the drug to Pregnancy Category C because of the lack of controlled data in humans. Animal studies have revealed an increased incidence of omphalocele if used in doses several
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Morishige, Yuta, Ko Fujimori, and Fumio Amano. "Differential Resuscitative Effect of Pyruvate and its Analogues on VBNC (Viable But Non-Culturable) Salmonella." Microbes and Environments 28, no. 2 (2013): 180–86. http://dx.doi.org/10.1264/jsme2.me12174.

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22

Daver, Naval, Aziz Nazha, Hagop M. Kantarjian, Rodney Haltom, and Farhad Ravandi. "Treatment of Hairy Cell Leukemia During Pregnancy: Are Purine Analogues and Rituximab Viable Therapeutic Options." Clinical Lymphoma Myeloma and Leukemia 13, no. 1 (2013): 86–89. http://dx.doi.org/10.1016/j.clml.2012.06.009.

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23

Goyal, Shuchi, Manjinder Singh, Divya Thirumal та ін. "In Silico Approaches to Developing Novel Glycogen Synthase Kinase 3β (GSK-3β)". Biomedicines 11, № 10 (2023): 2784. http://dx.doi.org/10.3390/biomedicines11102784.

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Alzheimer’s disease (AD) is caused by plaque agglomeration and entanglement in several areas of the neural cells, which leads to apoptosis. The main etiology of AD is senile dementia, which is linked to amyloid-beta (Aβ) deregulation and tau perivascular pathogeny. Hyperphosphorylated tau has a propensity for microtubules, which elevate the instability and tau-protein congregates, leading to accumulation of neurofibrillary tangles (NFTs). Tau hyperphosphorylation is susceptible to GSK-3, which has led to an emerging hypothesis regarding the pathogenesis of AD. Accordingly, attempts have been m
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Ma, Dik-Lung, Chun Wu, Ke-Jia Wu, and Chung-Hang Leung. "Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells." Molecules 24, no. 15 (2019): 2739. http://dx.doi.org/10.3390/molecules24152739.

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Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.
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Yin, Naibo, Paul W. R. Harris, Mengyang Liu, et al. "Enhancing the Oral Bioavailability of Glutathione Using Innovative Analogue Approaches." Pharmaceutics 17, no. 3 (2025): 385. https://doi.org/10.3390/pharmaceutics17030385.

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Background: Glutathione (GSH) is an essential antioxidant that protects against oxidative stress, but its oral bioavailability is below 1% due to enzymatic degradation and poor gastrointestinal absorption. Improving the oral bioavailability of GSH could significantly enhance its therapeutic efficacy. Methods: This study synthesised GSH analogues with chemical modifications to improve bioavailability. Seven GSH derivatives were designed: three analogues with altered stereochemistry (1.62, 1.63, and 1.64) and three N-methylated derivatives (1.65, 1.70, and 1.71), alongside a native GSH (1.61). T
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Huang, Lina A., Kelly X. Huang, Jui Tu, Fouad Kandeel, and Junfeng Li. "Ramatroban-Based Analogues Containing Fluorine Group as Potential 18F-Labeled Positron Emission Tomography (PET) G-Protein Coupled Receptor 44 (GPR44) Tracers." Molecules 26, no. 5 (2021): 1433. http://dx.doi.org/10.3390/molecules26051433.

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Diabetes remains one of the fastest growing chronic diseases and is a leading source of morbidity and accelerated mortality in the world. Loss of beta cell mass (BCM) and decreased sensitivity to insulin underlie diabetes pathogenesis. Yet, the ability to safely and directly assess BCM in individuals with diabetes does not exist. Measures such as blood glucose provide only a crude indirect picture of beta cell health. PET imaging could, in theory, allow for safe, direct, and precise characterization of BCM. However, identification of beta cell-specific radiolabeled tracers remains elusive. G-p
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Yin, Runkai, Kelly X. Huang, Lina A. Huang, et al. "Indole-Based and Cyclopentenylindole-Based Analogues Containing Fluorine Group as Potential 18F-Labeled Positron Emission Tomography (PET) G-Protein Coupled Receptor 44 (GPR44) Tracers." Pharmaceuticals 16, no. 9 (2023): 1203. http://dx.doi.org/10.3390/ph16091203.

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Recently, growing evidence of the relationship between G-protein coupled receptor 44 (GPR44) and the inflammation-cancer system has garnered tremendous interest, while the exact role of GPR44 has not been fully elucidated. Currently, there is a strong and urgent need for the development of non-invasive in vivo GPR44 positron emission tomography (PET) radiotracers that can be used to aid the exploration of the relationship between inflammation and tumor biologic behavior. Accordingly, the choosing and radiolabeling of existing GPR44 antagonists containing a fluorine group could serve as a viabl
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Keeley, Aaron B., Kopranovic Kopranovic, Lorenzo Vincenzo Di, et al. "Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors." Journal of Medicinal Chemistry 67, no. 1 (2023): 572–85. https://doi.org/10.1021/acs.jmedchem.3c01779.

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Screening of ultra-low-molecular weight ligands (MiniFrags) successfully identified viable chemical starting points for a variety of drug targets. Here we report the electrophilic analogues of MiniFrags that allow the mapping of potential binding sites for covalent inhibitors by biochemical screening and mass spectrometry. Small electrophilic heterocycles and their N-quaternized analogues were first characterized in the glutathione assay to analyze their electrophilic reactivity. Next, the library was used for systematic mapping of potential covalent binding sites available in human histone de
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Melnikova, E. V., A. A. Goryaev, M. V. Savkina, et al. "International Approaches to Regulation of Medicinal Products Containing Viable Human Cells." BIOpreparations. Prevention, Diagnosis, Treatment 18, no. 3 (2018): 150–60. http://dx.doi.org/10.30895/2221-996x-2018-18-3-150-160.

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The intensive development of cellular technologies stipulates the introduction at the global level of medicinal products based on viable human cells, which in most countries are referred to as biomedical cell products. The authors conducted a comparative analysis of the regulatory framework in different countries and determined special aspects of regulation of cell therapy products (analogues of biomedical cell products). Some countries have mechanisms for priority review of cell therapy products for marketing authorization, such as accelerated assessment, accelerated approval, or conditional
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Wang, Guofang, Jian Dong, and Liping Deng. "Overview of Cantharidin and its Analogues." Current Medicinal Chemistry 25, no. 17 (2018): 2034–44. http://dx.doi.org/10.2174/0929867324666170414165253.

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Background: Cantharidin has been categorized as highly toxicant in Chinese medicine. But cantharidin can efficiently treat different types of diseases, such as molluscum contagiosum. While cantharidin is quite useful, unfortunately, due to its side effects, increasing regulations have limited access to this useful therapeutic option. Cantharidin's toxic effects have caused it to fall into disuse for most legitimate medical purposes. Although cantharidin generates effects and its advantages must be realized. Recently, cancer affects people’s life more and more. Because cantharidin can treat som
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Stevens, Katharina. "REASONING BY PRECEDENT—BETWEEN RULES AND ANALOGIES." Legal Theory 24, no. 3 (2018): 216–54. http://dx.doi.org/10.1017/s1352325218000113.

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ABSTRACTThis paper investigates the process of reasoning through which a judge determines whether a precedent-case gives her a binding reason to follow in her present-case. I review the objections that have been raised against the two main accounts of reasoning by precedent: the rule-account and the analogy-account. I argue that both accounts can be made viable by amending them to meet the objections. Nonetheless, I believe that there is an argument for preferring accounts that integrate analogical reasoning: any account of reasoning by precedent that is descriptively minimally adequate will l
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Decrop, Maylis, Claire Espanel, Jerome Guillard, et al. "Pyrrolo[2,3-b]Pyridinic Derivatives Induce Cell Growth Inhibition of the Myeloblastic HL-60 Cell Line." Blood 108, no. 11 (2006): 4400. http://dx.doi.org/10.1182/blood.v108.11.4400.4400.

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Abstract Cytokins, N6-subsitued adenine derivatives play an important role in many different processes in plant development (Mok et al, Annu Rev Plant. Physiol Plant Mol Biol2001, 52:89–118), including the cell growth and division control, the vegetable cell differentiation with auxin and the storage of various metabolites as alkaloids (Yahia et al, Plant Science1998, 133:9–15). Furthermore, several studies suggest that cytokinins and their purin derivated are able to control mammalian cell apoptosis and differentiation of human leukemic cells (HL-60 myeloblastic cell line) into mature granulo
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Fadnavis, N. W., A. Deshpande, S. Chauhan, and U. T. Bhalerao. "Peptide synthesis mediated by immobilized and viable baker's yeast in reverse micelles: synthesis of leucine enkephalin analogues." Journal of the Chemical Society, Chemical Communications, no. 21 (1990): 1548. http://dx.doi.org/10.1039/c39900001548.

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Petik, Ihor, Anna Belinska, Ekaterina Kunitsia, et al. "Processing of ethanol-containing waste of oil neutralization in the technology of hand cleaning paste." Eastern-European Journal of Enterprise Technologies 1, no. 10 (109) (2021): 23–29. http://dx.doi.org/10.15587/1729-4061.2021.225233.

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The graphical dependence of the washing capacity of ethanol-containing soapstock on the concentration in an aqueous solution and the temperature of interaction with the polluted material has been determined. It is proposed to use a 40 % aqueous solution of ethanol-containing soapstock in the hand cleaning paste technology. This soapstock solution has a washing capacity of 92–98 % at the temperature of interaction with the polluted material of 25–40 °C. The regularity of the effect of the structurant content on the consistency of hand cleaning paste was investigated using an approximating polyn
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Ihor, Petik, Belinska Anna, Kunitsia Ekaterina, et al. "Processing of ethanol-containing waste of oil neutralization in the technology of hand cleaning paste." Eastern-European Journal of Enterprise Technologies 1, no. 10(109) (2021): 23–29. https://doi.org/10.15587/1729-4061.2021.225233.

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The graphical dependence of the washing capacity of ethanol-containing soapstock on the concentration in an aqueous solution and the temperature of interaction with the polluted material has been determined. It is proposed to use a 40 % aqueous solution of ethanol-containing soapstock in the hand cleaning paste technology. This soapstock solution has a washing capacity of 92–98 % at the temperature of interaction with the polluted material of 25–40 °C. The regularity of the effect of the structurant content on the consistency of hand cleaning paste was investigat
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Lewis, Dewi, A. Rabdel Ruiz-Salvador, Ariel Gómez, et al. "Zeolitic imidazole frameworks: structural and energetics trends compared with their zeolite analogues." CrystEngComm 11 (July 24, 2009): 2272–76. https://doi.org/10.5281/zenodo.14782479.

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We use periodic DFT calculations to compute the total energy of known zeolitic imidazole frameworks (ZIFs) together with those of hypothetical porous ZIFs. We show that the total energy of ZIFs decreases with increasing density, in a similar fashion to the alumino- silicate zeolites, but with a more complex energy landscape. The computational evaluation of the stability of hypothetical ZIFs is useful in the search for viable synthesis targets. Our results suggest that a number of hitherto undiscovered nanoporous topologies should be amenable to synthesis
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Krátký, Martin, Karolína Jaklová, Šárka Štěpánková, Katarína Svrčková, Václav Pflégr, and Jarmila Vinšová. "N-[3,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide Analogues: Novel Acetyl- and Butyrylcholinesterase Inhibitors." Current Topics in Medicinal Chemistry 20, no. 23 (2020): 2094–105. http://dx.doi.org/10.2174/1568026620666200819154722.

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Background: Development of acetyl- (AChE) and butyrylcholinesterase (BuChE) inhibitors belongs to viable strategies for the treatment of dementia and other diseases related to decrease in cholinergic neurotransmission. Objective: That is why we designed twenty-two analogues of a dual AChEBuChE salicylanilide inhibitor, N-[3,5-bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide 1, to improve its potency. Methods: We prepared N,N-disubstituted (thio)carbamates via direct acylation with (thio)carbamoyl chloride, N-n-alkyl monosubstituted carbamates using isocyanates as well as its salicylanili
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38

Mathieu, Veronique, Stefano Superchi, Marco Masi, Patrizia Scafato, Alexander Kornienko, and Antonio Evidente. "In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin." Toxins 14, no. 8 (2022): 517. http://dx.doi.org/10.3390/toxins14080517.

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Natural compounds have always represented an important source for new drugs. Although fungi represent one such viable source, to date, no fungal metabolite has been marketed as an anticancer drug. Based on our work with phytotoxins as potential chemical scaffolds and our recent findings involving three phytopathogenic fungi, i.e., Cochliobolus australiensis, Kalmusia variispora and Hymenoscyphus fraxineus, herein, we evaluate the in vitro anti-cancer activity of the metabolites of these fungi by MTT assays on three cancer cell models harboring various resistance levels to chemotherapeutic drug
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39

Sulaiman, Karina, Madhavilatha Vuppali, and Kenneth Abreo. "Patient Outcome in Pregnancy Requiring Dialysis: A Case Series." Open Urology & Nephrology Journal 7, no. 1 (2014): 52–55. http://dx.doi.org/10.2174/1874303x01407010052.

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The optimal management of pregnant dialysis patients remains a great challenge for nephrologists, end-stage renal disease being a predictor of adverse outcomes in this condition. We report a single-center experience of four patients requiring dialysis during pregnancy, all of which resulted in successful delivery of viable infants. Our success rate may reflect an overall improvement in management of this population, with special attention paid to multiple risk factors. These include blood pressure and volume control, anemia management with erythropoietin analogues, nutritional intake and total
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., Anjanaraj, Shridhar N. Deshpande, Anagha ., and B. C. Revanasiddappa. "Synthesis, in silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives." Research Journal of Chemistry and Environment 29, no. 3 (2025): 1–6. https://doi.org/10.25303/293rjce0106.

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A new class of 1,3,4-oxadiazole derivatives (O1-4) was synthesized and physically characterized by using spectroscopic (IR, 1H-NMR, Mass) methods. In silico studies were performed for all the new compounds and were put through ADME screening with Schrodinger suite 2020-4. Some of the compounds were tested for in vivo antidepressant efficacy utilizing the Forced swimming test and Tail suspension test. The final 1,3,4-oxadiazole analogues can potentially be developed into viable antidepressant drugs and might be beneficial as lead compound for pharmaceutical firms based on the in silico and in v
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41

Sturgeon, Robert S., Leslie M. Cooper, and Robert J. Howell. "Pupil Response: A Psychophysiological Measure of Fear during Analogue Desensitization." Perceptual and Motor Skills 69, no. 3_suppl (1989): 1351–67. http://dx.doi.org/10.2466/pms.1989.69.3f.1351.

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15 highly aroused snake phobics individually constructed fear hierarchies by selecting colored photographs of snakes. Subjects either imagined fear scenes based on their photographs or were exposed to duplicate projected slides during desensitization. Pupillary responses of the Slide Group were also recorded before, during, and after desensitization. Fear of snakes was significantly reduced for both groups within five or fewer desensitization sessions. Changes in pupil size of the Slide Group appear to reflect arousal of fear as well as reduction of fear after treatment. Current technology mak
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42

Sturgeon, Robert S., Leslie M. Cooper, and Robert J. Howell. "Pupil Response: A Psychophysiological Measure of Fear during Analogue Desensitization,." Perceptual and Motor Skills 69, no. 3-2 (1989): 1351–67. http://dx.doi.org/10.1177/00315125890693-254.

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15 highly aroused snake phobics individually constructed fear hierarchies by selecting colored photographs of snakes. Subjects either imagined fear scenes based on their photographs or were exposed to duplicate projected slides during desensitization. Pupillary responses of the Slide Group were also recorded before, during, and after desensitization. Fear of snakes was significantly reduced for both groups within five or fewer desensitization sessions. Changes in pupil size of the Slide Group appear to reflect arousal of fear as well as reduction of fear after treatment. Current technology mak
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43

Kim, Yang II, Katsunori Kawano, Shigeru Goto, Takanori Yoshida, and Naoshi Kamada. "Efficacy of prostacyclin analogue (OP-2507) in viable hepatic grafts from pigs with non-beating hearts." Transplant International 7, s1 (1994): 199–203. http://dx.doi.org/10.1111/j.1432-2277.1994.tb01346.x.

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MASUNO, MAKO N., BYRON C. ROBINSON, and AVINASH S. PHADKE. "A new porphycene-derived ring structure: octaethylbenzochloracene." Journal of Porphyrins and Phthalocyanines 05, no. 02 (2001): 177–80. http://dx.doi.org/10.1002/jpp.330.

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The synthesis of a new ring structure, octaethylbenzochloracene (6), derived from octaethylporphycene is reported. A viable route to the benzochloracene is shown and parallels the transformation of porphyrin to benzochlorin. Octaethylbenzochloracene's spectral data shows a unique UV–vis spectrum and an interesting NMR spectrum. Unfortunately, an attempt to synthesize the analogous purpurin derivative, purpuracene (8), failed.
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45

Wiesbrock, Anja. "Granting Citizenship-related Rights to Third-Country Nationals: An Alternative to the Full Extension of European Union Citizenship?" European Journal of Migration and Law 14, no. 1 (2012): 63–94. http://dx.doi.org/10.1163/157181612x628282.

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Abstract This article discusses the extension of citizenship-related rights to third-country nationals (TCNs) and their analogous interpretation with the rights enjoyed by European Union citizens. Starting with a discussion of the limited possibilities of fully extending Union citizenship to TCNs, it proceeds to discuss the Court’s case law regarding the application of EU general principles of law to TCNs and the interpretation of Union law concepts. It is argued that granting TCNs citizenship-related rights, such as the right to move freely within the EU and the right to non-discrimination on
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46

Mehta, Mona, Abdu Adem, and Marwan Sabbagh. "New Acetylcholinesterase Inhibitors for Alzheimer's Disease." International Journal of Alzheimer's Disease 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/728983.

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Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic improvement in Alzheimer's disease (AD) because cholinergic deficit is a consistent and early finding in AD. The treatment approach of inhibiting peripheral AchE for myasthenia gravis had effectively proven that AchE inhibition was a reachable therapeutic target. Subsequently tacrine, donepezil, rivastigmine, and galantamine were developed and approved for the symptomatic treatment of AD. Since then, multiple cholinesterase inhibitors (ChEI) continue to be developed. These include newer ChEIs, naturally derived ChEI
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47

Carollo, Angela, Stefano Papi, Chiara M. Grana, Luigi Mansi, and Marco Chinol. "State of the Art and Recent Developments of Radiopharmaceuticals for Pancreatic Neuroendocrine Tumors Imaging." Current Radiopharmaceuticals 12, no. 2 (2019): 107–25. http://dx.doi.org/10.2174/1874471012666190306104450.

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Background: Neuroendocrine Tumors (NETs) are relatively rare tumors, mainly originating from the digestive system, that tend to grow slowly and are often diagnosed when metastasised. Surgery is the sole curative option but is feasible only in a minority of patients. Among them, pancreatic neuroendocrine tumors (pancreatic NETs or pNETs) account for less than 5% of all pancreatic tumors. Viable therapeutic options include medical treatments such as biotherapies and more recently Peptide Receptor Radionuclide Therapies (PRRT) with radiolabeled somatostatin analogues. Molecular imaging, with main
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48

Sessler, Jonathan L., Jeong Tae Lee, Zhonping Ou, et al. "Chemical and electrochemical oxidation of N-alkyl cyclo[n]pyrroles." Journal of Porphyrins and Phthalocyanines 10, no. 12 (2006): 1329–36. http://dx.doi.org/10.1142/s1088424606000703.

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Cyclo[n]pyrroles ( n = 6, 7, and 8), are expanded porphyrins that lack bridging meso carbon atoms. They adopt conformations that are near-planar and show features that are consistent with global aromaticity. In previous work, involving studies of cyclo[8]pyrroles, it was found that, in contrast to what is true for porphyrins, reductive per- N -alkylation led to the formation of non-planar products that displayed few signs of extended conjugation. These octa- N -alkylated species could be reoxidized electrochemically to produce dicationic, octa- N -substituted analogues of the starting aromatic
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49

Kernen, Rachelle, Kathryn J. Amos, Ingrid Anell, Sian Evans, and Leticia Rodriguez-Blanco. "The role of salt basins in the race to net zero: a focus on Australian basins and key research topics." Australian Energy Producers Journal 64, no. 2 (2024): S402—S406. http://dx.doi.org/10.1071/ep23213.

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Globally, many salt basins host highly productive fossil fuel resources and provide excellent opportunities for developing economically viable clean energy systems such as (1) energy storage in salt caverns, including hydrogen, helium, natural gas, and other economic gases; (2) permanent sequestration of carbon dioxide; (3) development of geothermal energy; (4) critical mineral exploration and extraction, and (5) natural hydrogen production. Despite the high potential to deploy financially viable clean energy solutions related to the formation and evolution of salt basins, our current knowledg
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50

Doig, Adrian I., Jessica T. Stadel, and Thomas G. Back. "A Computational Study of Heteroatom Analogues of Selenoxide and Selenone syn Eliminations." Molecules 29, no. 20 (2024): 4915. http://dx.doi.org/10.3390/molecules29204915.

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Selenoxide syn elimination is a widely used method for the synthesis of alkenes because it proceeds under exceptionally mild conditions, typically with excellent regio- and stereoselectivity. Surprisingly, hetero-selenoxide eliminations, where one or both olefinic carbon atoms are replaced with heteroatoms, have been little investigated, and their selenonyl counterparts even less so. A variety of such reactions, where the heteroatoms included combinations of O, N and S, as well as C, were investigated computationally. Selenoxides typically have lower activation energies and are slightly endoth
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