Log in

Relevant bibliographies by topics / Analysis of Phenylephrine / Journal articles

To see the other types of publications on this topic, follow the link: Analysis of Phenylephrine.

Journal articles on the topic 'Analysis of Phenylephrine'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Analysis of Phenylephrine.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Mestre, Yolanda Fuster, Luis Lahuerta Zamora, and José Martínez Calatayud. "Determination of Phenylephrine Hydrochloride by Flow Injection Analysis with Chemiluminescence Detection." Journal of AOAC INTERNATIONAL 84, no. 1 (2001): 13–18. http://dx.doi.org/10.1093/jaoac/84.1.13.

Full text

Abstract:

Abstract A new method is proposed for the determination of phenylephrine hydrochloride by flow injection analysis with direct chemiluminescence detection. The method is based on the oxidation of the drug by potassium permanganate in sulfuric acid medium at 80°C. The calibration graph is linear over the range 0.03–8 ppm phenylephrine hydrochloride, with a relative standard deviation (n = 51, 0.5 ppm) of 1.1% and sample throughput of 134/h. The influence of 38 different foreign compounds was tested, and the method was applied to the determination of phenylephrine hydrochloride in 8 different pha

APA, Harvard, Vancouver, ISO, and other styles

2

Christ, George J., Brian Stone, and Arnold Melman. "Age-dependent alterations in the efficacy of phenylephrine-induced contractions in vascular smooth muscle isolated from the corpus cavernosum of impotent men." Canadian Journal of Physiology and Pharmacology 69, no. 7 (1991): 909–13. http://dx.doi.org/10.1139/y91-138.

Full text

Abstract:

Steady-state contractile responses elicited by phenylephrine activation of the α1-adrenergic receptor subtype were studied in vascular smooth muscle strips isolated from the corpus cavernosum of impotent men. The dissociation constant of phenylephrine was determined by the method of partial irreversible receptor inactivation over a wide range of α1-adrenergic receptor alkylation levels. Statistical analysis of mean population values revealed a significantly greater mean efficacy for phenylephrine-induced contractions in older patients (60–73 years old) than in younger patients (40–59 years old

APA, Harvard, Vancouver, ISO, and other styles

3

Garg, Heena, Vishnu Narayanan M R., Puneet Khanna, and Bharat Yalla. "Comparison of Phenylephrine Bolus and Infusion Regimens on Maternal and Fetal Outcomes During Cesarean Delivery: A Systematic Review and Meta-Analysis." Anesthesia & Analgesia 139, no. 6 (2024): 1144–55. http://dx.doi.org/10.1213/ane.0000000000007156.

Full text

Abstract:

BACKGROUND: A systematic review and meta-analysis was conducted to compare phenylephrine boluses versus prophylactic infusion in parturients undergoing cesarean delivery under spinal or combined spinal-epidural anesthesia on feto-maternal outcomes. METHODS: Medline, Embase, Cochrane, and US Clinical registry databases were searched. Studies comparing phenylephrine boluses (both therapeutic and prophylactic) with infusion (both fixed- and variable-rate) assessing various feto-maternal outcomes were included. The primary outcome was the incidence of maternal hypotension. Secondary maternal outco

APA, Harvard, Vancouver, ISO, and other styles

4

Patel, Satish A., and Dharmendrasinh A. Baria. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF NAPHAZOLINE HCL AND PHENYLEPHRINE HCL IN EYE DROPS." INDIAN DRUGS 57, no. 06 (2020): 26–31. http://dx.doi.org/10.53879/id.57.06.11613.

Full text

Abstract:

A first order derivative UV-spectrophotometric method was developed to quantify naphazoline hydrochloride and phenylephrine hydrochloride in eye drops. Naphazoline hydrochloride and phenylephrine hydrochloride were estimated at 275.6nm (zero crossover point of phenylephrine hydrochloride) and 289.4nm (zero crossover point of naphazoline hydrochloride), respectively. The method was found to be linear in the concentration range of 10 - 25 µg/ml for naphazoline hydrochloride and 20 - 60 µg/ml for phenylephrine hydrochloride. The developed method was subjected to validation in accordance with ICH

APA, Harvard, Vancouver, ISO, and other styles

5

Badran, Ahmed S., Karim S. Shata, Ahmed Elgammal, et al. "Comparison of phenylephrine, ephedrine, and norepinephrine for the prevention and treatment of spinal-induced hypotension in pre-eclamptic patients undergoing caesarean section: A systematic review and network meta-analysis." Indian Journal of Anaesthesia 69, no. 6 (2025): 526–39. https://doi.org/10.4103/ija.ija_62_25.

Full text

Abstract:

Background and Aims: Spinal-induced hypotension in parturients with pre-eclampsia (PE) can lead to adverse perinatal outcomes, making effective prophylaxis and treatment crucial. We aim to compare the prophylactic and therapeutic roles of phenylephrine, ephedrine, and norepinephrine (NE) in treating post-spinal hypotension in PE patients. Methods: We conducted a comprehensive search of various databases up to June 2024, focusing on randomised clinical trials (RCTs). Standardised mean differences (SMDs) were used for continuous outcomes, while odds ratios (ORs) were employed for binary outcomes

APA, Harvard, Vancouver, ISO, and other styles

6

Dyer, Robert A., Anthony R. Reed, Dominique van Dyk, et al. "Hemodynamic Effects of Ephedrine, Phenylephrine, and the Coadministration of Phenylephrine with Oxytocin during Spinal Anesthesia for Elective Cesarean Delivery." Anesthesiology 111, no. 4 (2009): 753–65. http://dx.doi.org/10.1097/aln.0b013e3181b437e0.

Full text

Abstract:

Background Hemodynamic responses to vasopressors used during spinal anesthesia for elective Cesarean delivery, have not been well described. This study compared the effects of bolus phenylephrine and ephedrine on maternal cardiac output (CO). The hypothesis was that phenylephrine, but not ephedrine, decreases CO when administered in response to hypotension during spinal anesthesia. Methods Forty-three patients were randomized to receive 80 microg of phenylephrine or 10 mg of ephedrine. Both pulse wave form analysis and transthoracic bioimpedance changes were used to estimate stroke volume in e

APA, Harvard, Vancouver, ISO, and other styles

7

Lesia, Savchenko, Uminska Kateryna, Bevz Nataliia, and Georgiyants Victoriya. "Selection and verification of the method for phynelefrine hydrochloride assay in Simanovsky ointment." ScienceRise: Pharmaceutical Science, no. 1(11) (August 26, 2019): 26–31. https://doi.org/10.15587/2519-4852.2018.122094.

Full text

Abstract:

Phenylephrine hydrochloride is a sympathomimetic with expressed local vasoconstrictor effect. Its ability to reduce swelling and hyperemia of the nasal mucosa is used in the Simanovsky ointment which is preparing for stock in the pharmacies of Ukraine. For the assay of phenylephrine hydrochloride in many single and multicomponent dosage forms, it is suggested to use a spectrophotometric method. However, in literary sources there are no examples of the use of spectrophotometric method for quantitative determination of phenylephrine hydrochloride in the studied ointment. <strong>Aim.</strong>&nb

APA, Harvard, Vancouver, ISO, and other styles

8

Ramesh, Sathyadeepak, and Ronald Mancini. "Dynamic Analysis of Müller’s Muscle Response to Phenylephrine." Ophthalmic Plastic and Reconstructive Surgery 32, no. 1 (2016): 46–48. http://dx.doi.org/10.1097/iop.0000000000000421.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

COLOMBO, Roberto, Giorgio MAZZUERO, Gianluca SPINATONDA, et al. "Comparison between spectral analysis and the phenylephrine method for the assessment of baroreflex sensitivity in chronic heart failure." Clinical Science 97, no. 4 (1999): 503–13. http://dx.doi.org/10.1042/cs0970503.

Full text

Abstract:

Baroreflex sensitivity assessed by means of the phenylephrine test plays a prognostic role in patients with previous myocardial infarction, but the need for drug injection limits the use of this technique. Recently, several non-invasive methods based on spectral analysis of systolic arterial pressure and heart period have been proposed, but their agreement with the phenylephrine test has not been investigated in patients with heart failure. The two methods (phenylephrine test and spectral analysis) were compared in a group of 49 patients with chronic congestive heart failure both at rest and d

APA, Harvard, Vancouver, ISO, and other styles

10

Shaidarova, L. G., I. A. Chelnokova, D. A. Koryakovtseva, and H. C. Budnikov. "Electrode with the Electrodeposited Gold–Bismuth Binary System for Voltammetric Determination of Phenylephrine, Paracetamol, and Caffeine." Uchenye Zapiski Kazanskogo Universiteta. Seriya Estestvennye Nauki 165, no. 1 (2023): 83–93. http://dx.doi.org/10.26907/2542-064x.2023.1.83-93.

Full text

Abstract:

The Au–Bi binary system electrodeposited on the surface of a glassy carbon electrode exhibits catalytic activity during the electrooxidation of phenylephrine, paracetamol, and caffeine that enhances the peak currents and decreases overvoltage in the oxidation of organic compounds. The potential difference between the peaks of oxidation on the modified electrode is 400 mV for phenylephrine and paracetamol and 300 mV for phenylephrine and caffeine, respectively. The possibility of simultaneous voltammetric determination of phenylephrine, paracetamol, and caffeine on the glassy carbon electrode m

APA, Harvard, Vancouver, ISO, and other styles

11

Nagarjuna, PJ, B. Tharun Kumar, and Buchi N. Nalluri. "Simultaneous Analysis of Phenylephrine HCl and Ketorolac Tromethamine in Bulk and Injectable Formulations by RP-HPLC-PDA Method." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 39–45. http://dx.doi.org/10.22270/jddt.v10i4-s.4204.

Full text

Abstract:

Rapid, isocratic and economical RP-HPLC-PDA method was developed for the simultaneous estimation of Phenylephrine HCl (PEH) and Ketorolac Tromethamine (KTR) in bulk and injectable dosage forms. Chromatographic separation was achieved with the Agilent Eclipse C18 column (150×4.6mm;5µ) and the mobile phase composed of methanol and 2mM Ammonium acetate in the ratio 43:57v/v at a flow rate of 1mL/min. The injection volume was 5µL and eluents were monitored at 220nm. Response was a linear function of concentration in the range 30–105 μg/mL for Phenylephrine HCl (PEH) and 10–35 μg/mL Ketorolac Trome

APA, Harvard, Vancouver, ISO, and other styles

12

Singh, Jyoti, Devang Bharti, Sharma Gill, and Shubhi Singhal. "A prospective, randomized, double-blind, comparative study of phenylephrine and ephedrine in treating hypotension during cesarean section under spinal anesthesia: Vasoconstrictors for Hypotension During CS." Serbian Journal of Anesthesia and Intensive Therapy 43, no. 7-8 (2021): 131–37. http://dx.doi.org/10.5937/sjait2108131s.

Full text

Abstract:

Introduction: Hypotension may affect 70-75% of patients undergoing cesarean section (CS) under spinal anesthesia (SA) and may have detrimental effects on both the mother and the fetus. Our study attempts to compare the effectiveness of phenylephrine and ephedrine in treating SA-induced hypotension in CS and their impact on the fetus. Methods: Forty adult pregnant female patients undergoing elective CS under SA were randomly divided into two groups to receive phenylephrine 100 µg IV bolus and ephedrine 6 mg IV bolus when the systolic blood pressure (SBP) dropped below 20% of the baseline. After

APA, Harvard, Vancouver, ISO, and other styles

13

Bloomfield, Daniel M., Steven Zweibel, J. Thomas Bigger, and Richard C. Steinman. "R-R variability detects increases in vagal modulation with phenylephrine infusion." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 5 (1998): H1761—H1766. http://dx.doi.org/10.1152/ajpheart.1998.274.5.h1761.

Full text

Abstract:

High-frequency power, measured from power spectral analysis of R-R variability, reflects vagal modulation of the sinus node. Unexpectedly, a recent study reported a decrease in high-frequency power during the infusion of phenylephrine despite a prolongation of R-R intervals, indicating an increase in vagal activity. To better define the limitations of high-frequency power to quantify vagal modulation, we measured high-frequency power during the infusion of phenylephrine (0.4, 0.8, and 1.2 μg ⋅ kg−1 ⋅ min−1) into 10 normal subjects. We found increasing doses of phenylephrine produced progressiv

APA, Harvard, Vancouver, ISO, and other styles

14

Yarmamedov, D. M., and O. M. Yarmamedova. "Analysis of the effectiveness of the effect on accommodation of phenylephrine in comparison with the combination of tropicamide and phenylephrine in children with mild myopia." Astrakhan medical journal 19, no. 3 (2024): 80–86. http://dx.doi.org/10.17021/1992-6499-2024-3-73-79.

Full text

Abstract:

At the moment there is a rapid increase in the number of children with myopia, including high degree, which undoubtedly leads to further disability of the population. This problem is more relevant for developing and developed countries. Purpose of the study: to carry out a comparative analysis of the effectiveness of the effect of phenylephrine instillations on the accommodative apparatus of the eye in comparison with the combination of tropicamide and phenylephrine in children with mild myopia. The study analyzed the results of examination of 2 groups of children. At the initial examination,

APA, Harvard, Vancouver, ISO, and other styles

15

Datar, Sudhir, Eddy Gutierrez, Adam Schertz, and Vidula Vachharajani. "Safety of Phenylephrine Infusion Through Peripheral Intravenous Catheter in the Neurological Intensive Care Unit." Journal of Intensive Care Medicine 33, no. 10 (2017): 589–92. http://dx.doi.org/10.1177/0885066617712214.

Full text

Abstract:

Objective: The traditional approach for infusing vasopressors is to insert central venous catheters, which is associated with several complications. Phenylephrine is a commonly used vasopressor in the neurologic intensive care unit (neuro ICU), and due to its modest potency, the risk of local tissue injury from extravasation may be overestimated. The purpose of this study was to evaluate the safety of phenylephrine infusion through peripheral intravenous catheter (PIV) in the neuro ICU. Patients and Methods: Retrospective review of all consecutive adults admitted to the neuro ICU receiving phe

APA, Harvard, Vancouver, ISO, and other styles

16

Da Costa, Tatiany Bertollo Cozer Ribeiro, Antônio De Melo Cabral, and Renata Pittella Cançado. "Comparison between cardiovascular effects of adrenaline and phenylephrine associated with lidocaine and the effects of felypressin with prilocaine during intrabucal anesthesia in ASA I patients." Revista Odonto Ciência 33, no. 1 (2018): 53. http://dx.doi.org/10.15448/1980-6523.2018.1.29848.

Full text

Abstract:

OBJECTIVE: Evaluate the cardiovascular effects by infiltration of 1:100.000 epinephrine and 1:2.500 phenylephrine associated with 2% lidocaine compared with the effects by infiltration of 0.03 IU/ml felypressin with 3% prilocaine, during surgery of third molars in ASA I patients.METHODS: Eighteen patients were divided into two groups. In group I (GI), the effects of epinephrine vs felypressin were evaluated and in group II (GII), the effects of phenylephrine vs felypressin. Cardiovascular parameters: systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and oxygen satu

APA, Harvard, Vancouver, ISO, and other styles

17

G, Rajitha, and Geetha Susmita Adepu. "Development and Validation of Stability Indicating UPLC Method for Simultaneous Estimation of Phenylephrine and Fexofenadine in Suspension Dosage Form." International Journal of Pharmaceutical Sciences and Nanotechnology 13, no. 5 (2020): 5069–74. http://dx.doi.org/10.37285/ijpsn.2020.13.5.3.

Full text

Abstract:

Phenylephrine and fexofenadine are widely used products for common cold and allergic conditions. In this study, a simple, reliable, sensitive and economical Ultra Performance Liquid Chromatographic (UPLC) method was developed and validated for the simultaneous estimation of phenylephrine and fexofenadine in suspension dosage form. Efficient chromatographic separation was achieved on Acquity UPLC HSS C18 x 1.8μm column with mobile phase consisting of orthophosphoric acid buffer (pH = 2.8) and acetonitrile (55:45% v/v) at a flow rate of 0.3ml.min-1 and 1μl injection volume. TUV detector was used

APA, Harvard, Vancouver, ISO, and other styles

18

Anandakumar, K., and P. Veerasundari. "Simultaneous Estimation of Paracetamol, Ambroxol Hydrochloride, Levocetirizine Dihydrochloride, and Phenylephrine Hydrochloride in Combined Tablet Formulation by First-Order Derivative Spectrophotometry." ISRN Spectroscopy 2014 (March 30, 2014): 1–8. http://dx.doi.org/10.1155/2014/248960.

Full text

Abstract:

Paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride are used in combination for the treatment of chronic sinusitis, rhinitis, fever, nasal discharge, sore throat, and wheezing. The present work deals with method development for simultaneous estimation of paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride in tablet formulation by first-order derivative spectrosphotometry. For determination of sampling wavelength, 10 μg/mL of each of paracetamol, ambroxol hydrochloride, levocetirizine dihydrochlori

APA, Harvard, Vancouver, ISO, and other styles

19

Williams, George, Vahed Maroufy, Laila Rasmy, et al. "Vasopressor treatment and mortality following nontraumatic subarachnoid hemorrhage: a nationwide electronic health record analysis." Neurosurgical Focus 48, no. 5 (2020): E4. http://dx.doi.org/10.3171/2020.2.focus191002.

Full text

Abstract:

OBJECTIVESubarachnoid hemorrhage (SAH) is a devastating cerebrovascular condition, not only due to the effect of initial hemorrhage, but also due to the complication of delayed cerebral ischemia (DCI). While hypertension facilitated by vasopressors is often initiated to prevent DCI, which vasopressor is most effective in improving outcomes is not known. The objective of this study was to determine associations between initial vasopressor choice and mortality in patients with nontraumatic SAH.METHODSThe authors conducted a retrospective cohort study using a large, national electronic medical re

APA, Harvard, Vancouver, ISO, and other styles

20

Patel, Mehul, Bhavna Patel, and Shraddha Parmar. "Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method." Journal of Spectroscopy 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/364750.

Full text

Abstract:

A simple, precise, rapid, and economic method was developed for the simultaneous determination of Ibuprofen and Phenylephrine HCl in bulk and combined dosage form. This method involves first-order derivative spectroscopy using 248 nm and 237 nm as zero crossing points for Ibuprofen and Phenylephrine HCl, respectively. For spectrophotometric method 0.1 N NaOH was used as a solvent. The linearity was established over the concentration range of 12–72 μg/mL and 1.5–22 μg/mL for Ibuprofen and Phenylephrine HCl with correlation coefficient (r2) of 0.9972 and 0.9981, respectively. The mean % recoveri

APA, Harvard, Vancouver, ISO, and other styles

21

Hartman, Thomas J., Jody L. Martin, R. John Solaro, Allen M. Samarel, and Brenda Russell. "CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms." American Journal of Physiology-Cell Physiology 296, no. 5 (2009): C1034—C1039. http://dx.doi.org/10.1152/ajpcell.00544.2008.

Full text

Abstract:

One of the unanswered questions in muscle hypertrophy is how new contractile units are inserted into a stable existing cytoskeletal meshwork. Regulation of actin capping by CapZ may play a role in remodeling processes, therefore, CapZ dynamics are determined during rapid growth of cardiac cells in vitro. Neonatal rat ventricular myocytes were infected with adenovirus expressing green fluorescent protein-CapZ β1 and responded normally to hypertrophic stimuli. CapZ dynamics were analyzed by fluorescence recovery after photobleaching in cultured myocytes treated with endothelin-1 (100 nM) or phen

APA, Harvard, Vancouver, ISO, and other styles

22

Makhova, M. V., E. V. Shikh, V. V. Strakhov, et al. "Clinical and experimental rationale for using phenylephrine with hypromellose for the treatment of extra accommodation strain in patients with myopia." Russian Journal of Clinical Ophthalmology 23, no. 1 (2023): 33–38. http://dx.doi.org/10.32364/2311-7729-2023-23-1-33-38.

Full text

Abstract:

Aim: to perform a comparative analysis of the clinical efficacy of 2.5% phenylephrine with and without hypromellose for the treatment of extra accommodation strain in schoolchildren with myopia and to perform an experimental evaluation of the pharmacological effective of active ingredient of the finished dosage form (FDF) of preparations containing 2.5% phenylephrine with and without excipients. Patients and Methods: this clinical study enrolled 122 schoolchildren, 11–17 years old, with extra accommodation strain of various severity. The children were split into two groups. The group 1 patient

APA, Harvard, Vancouver, ISO, and other styles

23

Totuk, Ozgun Melike Gedar, Ayse Yagmur Kanra, and Umit Aykan. "Clinical value of phenylephrine testing in the upper and lower eyelids of patients with aponeurotic and congenital eyelid ptosis." International Journal of Ophthalmology 15, no. 9 (2022): 1444–52. http://dx.doi.org/10.18240/ijo.2022.09.06.

Full text

Abstract:

AIM: To characterize the phenylephrine test in aponeurotic and congenital eyelid ptosis, to determine the appropriate timing of the phenylephrine test, and to assess the responses of the upper and lower eyelids. METHODS: This was a retrospective analysis of 140 eyes of 87 patients (mean age 52.29±16.45y; 22 males, 65 females) with upper eyelid ptosis. Totally 88.6% had aponeurotic and 11.4% had congenital ptosis. For the evaluation of the responses of the upper and lower eyelids to topical 2.5% phenylephrine, the scleral show height, the marginal reflex distance (MRD) between the inferior marg

APA, Harvard, Vancouver, ISO, and other styles

24

Patel, Harsh B., and Paresh U. Patel. "RP-HPLC Method for Simultaneous Estimation of Ciprofloxacin and Phenylephrine in Combined Dosage Forms." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 4 (2014): 2631–37. http://dx.doi.org/10.37285/ijpsn.2014.7.4.4.

Full text

Abstract:

A new, simple, rapid, selective, precise and accurate gradient RP-HPLC method has been developed for simultaneous estimation of Ciprofloxacin and Phenylephrine Hydrochloride in combined dosage form. The separation was achieved by using Thermic Hypersil C column (250 mm x 4.6 mm, 5 µm particle size) coupled with a guard column of same material, in mobile phase Acetonitrile: Methanol: Phosphate Buffer pH 6 (10: 65: 25, v/v/v). The flow rate was 1.0 ml/min and the separated drugs were detected using UV detector at the wavelength of 220 nm. The analysis was performed at room temperature (37 ± 2 ºC

APA, Harvard, Vancouver, ISO, and other styles

25

Ballieu, Paul, Yasaman Besharatian, and Safdar Ansari. "Safety and Feasibility of Phenylephrine Administration Through a Peripheral Intravenous Catheter in a Neurocritical Care Unit." Journal of Intensive Care Medicine 36, no. 1 (2019): 101–6. http://dx.doi.org/10.1177/0885066619887111.

Full text

Abstract:

Background/Objective: Blood pressure optimization and maintenance of cerebral and spinal perfusion pressure are mainstays in the treatment of a neurocritically ill patient. Traditionally, central venous access has been required for vasopressor administration, with risk of inherent complications. The authors have previously reported pilot data on the safety of peripheral administration of phenylephrine in a neurocritical care unit. In this follow-up, we report the safety, feasibility, and potential efficacy of peripheral administration of low-concentration phenylephrine in a more robust cohort.

APA, Harvard, Vancouver, ISO, and other styles

26

Kamal, Rabia, Muhammad Arsalan Jamil, Shaista Uzair, and Syed Farjad Sultan. "Comparison Between Efficacy of Norepinephrine and Phenylephrine Boluses for Prevention of Spinal Anesthesia-Induced Hypotension in Obstetrical Patients Undergoing Emergency Cesarean Section." Biological and Clinical Sciences Research Journal 6, no. 4 (2025): 31–36. https://doi.org/10.54112/bcsrj.v6i4.1656.

Full text

Abstract:

Spinal anesthesia-induced hypotension (SAH) is a common complication during emergency cesarean sections, which can negatively affect both maternal and neonatal outcomes. This study aims to compare the efficacy of norepinephrine and phenylephrine boluses in preventing SAH in obstetric patients. Objective: To compare the efficacy of norepinephrine and phenylephrine boluses for preventing spinal anesthesia-induced hypotension (SAH) in obstetric patients undergoing emergency cesarean section. Methods: A double-blind randomized controlled trial was conducted at Dr. Ruth K.M. Pfau Civil Hospital Kar

APA, Harvard, Vancouver, ISO, and other styles

27

Goldberger, J. J., M. W. Ahmed, M. A. Parker, and A. H. Kadish. "Dissociation of heart rate variability from parasympathetic tone." American Journal of Physiology-Heart and Circulatory Physiology 266, no. 5 (1994): H2152—H2157. http://dx.doi.org/10.1152/ajpheart.1994.266.5.h2152.

Full text

Abstract:

Time and frequency domain measurements of heart rate variability have been used as indexes of parasympathetic tone. This study evaluates the effects of parasympathetic stimulation on these indexes. Ten normal subjects (5 females, 5 males; age 27.4 +/- 5.1 yr) were evaluated in the Clinical Research Center. Five-minute electrocardiographic recordings were obtained at baseline and during 1) combined alpha-adrenergic stimulation with baroreflex-increased cardiac parasympathetic activity produced by phenylephrine infusion; 2) parasympathetic blockade (atropine 0.04 mg/kg); and 3) isolated alpha-ad

APA, Harvard, Vancouver, ISO, and other styles

28

Kang, Hyun, Tae-Yun Sung, Young Seok Jee, et al. "A Comparison of Norepinephrine versus Phenylephrine to Prevent Hypotension after Spinal Anesthesia for Cesarean Section: Systematic Review and Meta-Analysis." Journal of Personalized Medicine 14, no. 8 (2024): 803. http://dx.doi.org/10.3390/jpm14080803.

Full text

Abstract:

Background: This systematic review and meta-analysis aimed to compare the effects of using phenylephrine or norepinephrine on the pH and base excess (BE) of the umbilical artery and vein in parturients undergoing cesarean section. Methods: The study protocol was registered in INPLASY. Independent researchers searched Ovid-Medline, Ovid-EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) databases and Google Scholar for relevant randomized controlled trials (RCTs). The primary outcome of this study was the umbilical artery (UA) or umbilical vein (UV) pH as neonatal condition at

APA, Harvard, Vancouver, ISO, and other styles

29

Detillieux, Karen A., Johanna T. A. Meij, Elissavet Kardami та Peter A. Cattini. "α1-Adrenergic stimulation of FGF-2 promoter in cardiac myocytes and in adult transgenic mouse hearts". American Journal of Physiology-Heart and Circulatory Physiology 276, № 3 (1999): H826—H833. http://dx.doi.org/10.1152/ajpheart.1999.276.3.h826.

Full text

Abstract:

Fibroblast growth factor (FGF-2), a mitogenic, angiogenic, and cardioprotective agent, is reported to be released from the postnatal heart by a mechanism of transient remodeling of the sarcolemma during contraction. This release can be increased with adrenergic stimulation. RNA blotting was used to assess whether FGF-2 synthesis in neonatal rat cardiomyocytes might also be regulated by adrenergic stimulation. FGF-2 RNA levels were increased after treatment with norepinephrine for 6 h or with the α-adrenergic agonist phenylephrine for 48 h. To assess an effect on transcription, neonatal rat car

APA, Harvard, Vancouver, ISO, and other styles

30

Ngan Kee, Warwick D. "A Random-allocation Graded Dose–Response Study of Norepinephrine and Phenylephrine for Treating Hypotension during Spinal Anesthesia for Cesarean Delivery." Anesthesiology 127, no. 6 (2017): 934–41. http://dx.doi.org/10.1097/aln.0000000000001880.

Full text

Abstract:

Abstract Background Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However, the relative potencies of these two vasopressors have not been fully determined in this context. Methods In a random-allocation, graded dose–response study, 180 healthy patients undergoing spinal anesthesia for elective cesarean delivery received a single bolus of norepinephrine in one of six different doses ranging from 4 to 12 µ

APA, Harvard, Vancouver, ISO, and other styles

31

Polcz, Monica, Kyle M. Hocking, Devin Chang, et al. "A brief report on the effects of vasoactive agents on peripheral venous waveforms in a porcine model." JRSM Cardiovascular Disease 9 (January 2020): 204800402094085. http://dx.doi.org/10.1177/2048004020940857.

Full text

Abstract:

Objectives Non-invasive venous waveform analysis (NIVA) is a recently described, novel technique to assess intravascular volume status. Waveforms are captured with a piezoelectric sensor; analysis in the frequency domain allows for calculation of a “NIVA value” that represents volume status. The aim of this report was to determine the effects of vasoactive agents on the venous waveform and calculated NIVA values. Design Porcine experimental model. Setting Operating theatre. Participants A piezoelectric sensor was secured over the surgically exposed saphenous vein in eight anesthetized pigs. Ma

APA, Harvard, Vancouver, ISO, and other styles

32

Mink, S. N., P. Jha, R. Wang, et al. "Effect of Continuous Arteriovenous Hemofiltration Combined with Systemic Vasopressor Therapy on Depressed Left Ventricular Contractility and Tissue Oxygen Delivery in Canine Escherichia coli Sepsis." Anesthesiology 83, no. 1 (1995): 178–90. http://dx.doi.org/10.1097/00000542-199507000-00021.

Full text

Abstract:

Background In a previous study, we showed that continuous arteriovenous hemofiltration (CAVH) reversed the depression in left ventricular (LV) contractility in canine Escherichia coli sepsis by the removal of a circulating substance the molecular weight of which is less than 30,000. Despite the normalization of LV contractility, however, we were unable to demonstrate an improvement in systemic arterial blood pressure (BP), presumably because the mechanisms underlying the depression in LV contractility and the decrease in BP are different in sepsis. In the current study, we examined the effect

APA, Harvard, Vancouver, ISO, and other styles

33

Qi, Nan, David Lockington, Huiming Wang, Nicholas A. Hill, Kanna Ramaesh, and Xiaoyu Luo. "Modeling Floppy Iris Syndrome and the Impact of Phenylephrine on Iris Buckling." International Journal of Applied Mechanics 10, no. 05 (2018): 1850048. http://dx.doi.org/10.1142/s1758825118500485.

Full text

Abstract:

Abnormal iris movement (floppy iris syndrome) during intraocular surgery is associated with an increased risk of intraoperative complications. We have previously investigated this scenario with respect to intracameral air in corneal endothelial transplantation, and described the concept of iris buckling. As a number of clinical interventions are recommended for addressing floppy iris syndrome, we wished to evaluate the impact of intracameral phenylephrine on iris buckling and so refine our mathematical model. We considered the stability of an iris structure under a uniform pressure loading. We

APA, Harvard, Vancouver, ISO, and other styles

34

Zhang, Hongying, DaLiao Xiao, Lawrence D. Longo та Lubo Zhang. "Regulation of α1-adrenoceptor-mediated contractions of uterine arteries by PKC: effect of pregnancy". American Journal of Physiology-Heart and Circulatory Physiology 291, № 5 (2006): H2282—H2289. http://dx.doi.org/10.1152/ajpheart.00321.2006.

Full text

Abstract:

Protein kinase C (PKC) plays an important role in the regulation of uterine artery contractility and its adaptation to pregnancy. The present study tested the hypothesis that PKC differentially regulates α1-adrenoceptor-mediated contractions of uterine arteries isolated from nonpregnant (NPUA) and near-term pregnant (PUA) sheep. Phenylephrine-induced contractions of NPUA and PUA sheep were determined in the absence or presence of the PKC activator phorbol 12,13-dibutyrate (PDBu). In NPUA sheep, PDBu produced a concentration-dependent potentiation of phenylephrine-induced contractions and shift

APA, Harvard, Vancouver, ISO, and other styles

35

Joshi, Shailendra, William L. Young, Huang Duong, et al. "Intracarotid Nitroprusside Does Not Augment Cerebral Blood Flow in Human Subjects." Anesthesiology 96, no. 1 (2002): 60–66. http://dx.doi.org/10.1097/00000542-200201000-00016.

Full text

Abstract:

Background The recent resurgence of interest in the cerebrovascular effects of nitroprusside can be attributed to the possibility of using nitric oxide donors in treating cerebrovascular insufficiency. However, limited human data suggest that intracarotid nitroprusside does not directly affect cerebrovascular resistance. In previous studies, physiologic or pharmacologic reactivity of the preparation was not tested at the time of nitroprusside challenge. The authors hypothesized that if nitric oxide is a potent modulator of human cerebral blood flow (CBF), then intracarotid infusion of nitropru

APA, Harvard, Vancouver, ISO, and other styles

36

Olds, William J., Shankaran Sundarajoo, Mark Selby, Biju Cletus, Peter M. Fredericks, and Emad L. Izake. "Noninvasive, Quantitative Analysis of Drug Mixtures in Containers Using Spatially Offset Raman Spectroscopy (SORS) and Multivariate Statistical Analysis." Applied Spectroscopy 66, no. 5 (2012): 530–37. http://dx.doi.org/10.1366/11-06554.

Full text

Abstract:

In this paper, spatially offset Raman spectroscopy (SORS) is demonstrated for noninvasively investigating the composition of drug mixtures inside an opaque plastic container. The mixtures consisted of three components including a target drug (acetaminophen or phenylephrine hydrochloride) and two diluents (glucose and caffeine). The target drug concentrations ranged from 5% to 100%. After conducting SORS analysis to ascertain the Raman spectra of the concealed mixtures, principal component analysis (PCA) was performed on the SORS spectra to reveal trends within the data. Partial least squares (

APA, Harvard, Vancouver, ISO, and other styles

37

Jalili, Saeed, Mitra Hojatansari, and Somaye Abdollahi Sabet. "Comparison of the Effects of Norepinephrine and Phenylephrine Infusion in Preventing Hypotension during Spinal Anesthesia for Cesarean Delivery: A Randomized, Double-Blind Clinical Trial." Archives of Iranian Medicine 28, no. 3 (2025): 149–54. https://doi.org/10.34172/aim.33931.

Full text

Abstract:

Background: Hypotension following spinal anesthesia is one of the most common complications of cesarean delivery, posing significant risks to both maternal and fetal health. The use of vasopressors is a primary method for the prevention and management of hypotension. Objective: This study aimed to compare the efficacy of norepinephrine and phenylephrine infusion in preventing hypotension in patients undergoing cesarean section under spinal anesthesia. Methods: In this randomized, double-blind clinical trial, 90 pregnant women at 37 weeks of gestation scheduled for elective cesarean delivery we

APA, Harvard, Vancouver, ISO, and other styles

38

Sanchaniya, Pinak M., Falgun A. Mehta, and Nirav B. Uchadadiya. "Development and Validation of an RP-HPLC Method for Estimation of Chlorpheniramine Maleate, Ibuprofen, and Phenylephrine Hydrochloride in Combined Pharmaceutical Dosage Form." Chromatography Research International 2013 (July 24, 2013): 1–6. http://dx.doi.org/10.1155/2013/424865.

Full text

Abstract:

The objective of this paper is to develope a simple, precise, accurate, and reproducible reversed phase high performance liquid chromatographic method for the quantitative determination of chlorpheniramine maleate, ibuprofen, and phenylephrine hydrochloride in combined pharmaceutical dosage form. Analysis was carried out using acetonitrile : mathanol : phoshphate buffer (50 : 20 : 30, v/v/v, pH 5.6) mobile phase at 1.0 mL/min flow rate and Sunfire C 18 column (5 μm × 250 mm × 4.6 mm) as stationary phase with detection wavelength of 220 nm. The retention times of chlorpheniramine maleate (CPM),

APA, Harvard, Vancouver, ISO, and other styles

39

Gioia, Marco, Maddalena De Bernardo, Sergio Pagliarulo, et al. "Evaluation of Tropicamide–Phenylephrine Mydriatic Eye Drop Instillation on Choroidal Thickness." Journal of Clinical Medicine 12, no. 19 (2023): 6355. http://dx.doi.org/10.3390/jcm12196355.

Full text

Abstract:

The purpose of this study is to evaluate choroidal thickness (ChT) at the subfoveal and peripheral level after the instillation of 0.5% tropicamide + 10% phenylephrine 9 hydrochloride eye drops by using OCT scans in enhanced depth image (EDI) mode. In total, 53 patients (30 males and 23 females) were involved, and the mean age was 25.62 ± 2.41 (age range: 23–36). The dominant eye was treated with tropicamide + phenylephrine (Visumidriatic Fenil 100 mg/mL + 5 mg/mL, Visufarma) while the nondominant eye was used as the control. An OCT analysis was performed on both eyes before and 30 min after t

APA, Harvard, Vancouver, ISO, and other styles

40

Al-Ezzy, Yehya K., Adnan R. Mahdi, and Suham T. Ameen. "Preparation of New Molecularly Imprinted Polymers and its Use in the Selective Extraction For Determination Phenylephrine Hydrochloride at Pharmaceuticals." International Journal of Drug Delivery Technology 9, no. 04 (2019): 651–59. http://dx.doi.org/10.25258/ijddt.9.4.23.

Full text

Abstract:

This study was aimed at four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using phenylephrine hydrochloride (PPH) as the template, methyl methacrylate (MMA) as monomer as well as trimethylol propane tri methacrylate (TMPTMA) and ethylene glycol dimethacrylate (EGDMA) as cross linkers respectively and benzoyl peroxide as initiator. The same composition was used in the preparation of non-imprinted polymers (NIPs), but without the template (Phenylephrine hydrochloride). For the preparation of membranes, different plasticizers were used in t

APA, Harvard, Vancouver, ISO, and other styles

41

Bhattarai, Mukem, Hema Basnett, Ateeb Das, et al. "Simultaneous Estimation of Paracetamol, Phenylephrine Hydrochloride and Triprolidine Hydrochloride by Second Order Derivative Spectroscopy." Asian Journal of Chemistry 31, no. 12 (2019): 2931–36. http://dx.doi.org/10.14233/ajchem.2019.22244.

Full text

Abstract:

A simple, sensitive and reproducible second order derivative UV spectrophotometric method was developed for simultaneous estimation of mixture of paracetamol, phenylephrine hydrochloride and triprolidine hydrochloride in the tablet dosage form. The method utilizes second order derivative technique, which helps to isolate the individual peaks of the mixture drugs and overcome the problem of merging of mixture peaks with each other. For quantification of paracetamol, phenylephrine hydrochloride and triprolidine hydrochloride wavelength selected were 244, 276 and 297 nm, respectively. The method

APA, Harvard, Vancouver, ISO, and other styles

42

LORD, S. W., R. H. CLAYTON, M. C. S. HALL, et al. "Reproducibility of three different methods of measuring baroreflex sensitivity in normal subjects." Clinical Science 95, no. 5 (1998): 575–81. http://dx.doi.org/10.1042/cs0950575.

Full text

Abstract:

1.Baroreflex sensitivity is a useful tool for investigating cardiovascular reflexes in a number of clinical settings. Several different methods of measuring baroreflex sensitivity are available. In order to determine a clinically useful non-invasive method of measuring baroreflex sensitivity we compared two methods (spectral analysis and the Valsalva manoeuvre) with regard to reproducibility, agreement with a standard invasive method (phenylephrine infusion) and failure rate. 2.Twenty-six healthy subjects aged 22 to 63 years attended on three separate occasions for measurement of baroreflex se

APA, Harvard, Vancouver, ISO, and other styles

43

Nishimura, Kanami, and Katsuaki Ito. "Pharmacological analysis of tonic contraction induced by phenylephrine in rat aorta." Japanese Journal of Pharmacology 49 (1989): 314. http://dx.doi.org/10.1016/s0021-5198(19)56777-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Birkett, C. L., C. A. Ray, E. A. Anderson, and R. F. Rea. "A signal-averaging technique for the analysis of human muscle sympathetic nerve activity." Journal of Applied Physiology 73, no. 1 (1992): 376–81. http://dx.doi.org/10.1152/jappl.1992.73.1.376.

Full text

Abstract:

We present a signal-averaging technique for analysis of human muscle sympathetic nerve activity (SNA). Nerve traffic was averaged by coupling signal acquisition to electrocardiographic R waves. The amplitude of the averaged waveform was multiplied by the number of R waves sampled to provide a measure of SNA in arbitrary units. This was compared with SNA measured by manual digitization of hard-copy records. In nine volunteers, SNA was increased or decreased with stepwise infusions of nitroprusside or phenylephrine: there were 10 5-min periods of data in each subject. Across all subjects, the co

APA, Harvard, Vancouver, ISO, and other styles

45

Panerai, R. B., M. A. James, and J. F. Potter. "Impulse response analysis of baroreceptor sensitivity." American Journal of Physiology-Heart and Circulatory Physiology 272, no. 4 (1997): H1866—H1875. http://dx.doi.org/10.1152/ajpheart.1997.272.4.h1866.

Full text

Abstract:

The impulse response function (IRF) can express the dynamic relationship between systolic arterial pressure (SAP) and pulse interval (PI) and, consequently, represents an alternative method to assess baroreceptor sensitivity (BRS) in humans. Five normotensive and 13 hypertensive subjects (age 68 +/- 5 yr, range 60-74 yr) were studied at rest in the supine position during baseline conditions and after injections of phenylephrine and sodium nitroprusside. SAP and PI signals were derived from multiple 5-min noninvasive recordings of arterial blood pressure (Finapres) and electrocardiogram. Standa

APA, Harvard, Vancouver, ISO, and other styles

46

Muneer, Khawer, Hina Khurshid, and Venkatesh H. K. "Comparison of Phenylephrine and Ephedrine in the Treatment of Hypotension and Its Effects on the Foetus after Subarachnoid Block for Caesarean Section." Journal of Evolution of Medical and Dental Sciences 10, no. 44 (2021): 3775–80. http://dx.doi.org/10.14260/jemds/2021/763.

Full text

Abstract:

BACKGROUND Subarachnoid block has been widely used for caesarean sections and is found to be safe. Hypotension being the most common complication may adversely affect both the mother and foetus. Different measures used to treat this hypotension include preloading with crystalloids/colloids and treatment with vasopressors. The standard choice of vasopressor agents such as ephedrine and phenylephrine is still a controversial issue. It is therefore important to compare the efficacy of the two drugs in the prevention and treatment of maternal hypotension after subarachnoid block and particularly a

APA, Harvard, Vancouver, ISO, and other styles

47

Lieberman, Jeremy A., John Feiner, Russ Lyon, and Mark D. Rollins. "Effect of Hemorrhage and Hypotension on Transcranial Motor-evoked Potentials in Swine." Anesthesiology 119, no. 5 (2013): 1109–19. http://dx.doi.org/10.1097/aln.0b013e31829d4a92.

Full text

Abstract:

Abstract Background: Transcranial motor-evoked potentials (TcMEPs) monitor spinal cord motor tract integrity. Using a swine model, the authors studied the effects of vasodilatory hypotension, hemorrhage, and various resuscitation efforts on TcMEP responses. Methods: Twelve pigs were anesthetized with constant infusions of propofol, ketamine, and fentanyl. Animals were incrementally hemorrhaged, until bilateral tibialis anterior TcMEP amplitude decreased to less than 40% of baseline or until 50% of the blood volume was removed. Mean arterial pressure (MAP), cardiac output (CO), and oxygen deliv

APA, Harvard, Vancouver, ISO, and other styles

48

Besard, M., V. Bafort, M. Wolfskeil, A. Moerman, S. De Hert, and C. Vanpeteghem. "Influence of continuous administration of phenylephine versus dobutamine on paraspinal oxygen saturation." Acta Anaesthesiologica Belgica 73, Supplement 1 (2022): 33–43. http://dx.doi.org/10.56126/73.s1.28.

Full text

Abstract:

Introduction: This randomized controlled trial evaluates the effect of continuous administration of phenylephrine versus dobutamine on paraspinal oxygenation, measured by near-infrared spectroscopy (NIRS). Paraspinal NIRS-monitoring evaluates the spinal oxygenation in an indirect, continuous and real-time manner. The influence of these drugs on the paraspinal oxygenation is unknown, but can be highly relevant during major aortic repair. Methods: This dissertation discusses a preliminary data analysis concerning the first twenty patients included. Phenylephrine or dobutamine were administered c

APA, Harvard, Vancouver, ISO, and other styles

49

Kee, Warwick D. Ngan, Kim S. Khaw, and Floria F. Ng. "Prevention of Hypotension during Spinal Anesthesia for Cesarean Delivery." Anesthesiology 103, no. 4 (2005): 744–50. http://dx.doi.org/10.1097/00000542-200510000-00012.

Full text

Abstract:

Background Many methods for preventing hypotension during spinal anesthesia for cesarean delivery have been investigated, but no single technique has proven to be effective and reliable. This randomized study studied the efficacy of combining simultaneous rapid crystalloid infusion (cohydration) with a high-dose phenylephrine infusion. Methods Nonlaboring patients scheduled to undergo elective cesarean delivery received an intravenous infusion of 100 mug/min phenylephrine that was started immediately after spinal injection and titrated to maintain systolic blood pressure near baseline values u

APA, Harvard, Vancouver, ISO, and other styles

50

Saha, Prerona, Chandita Konwar, Aditya Pandey, and Prabal Bharali. "Comparison of the effect of intravenous phenylephrine and norepinephrine boluses for post-spinal hypotension on neonatal outcome in elective caesarean section: A randomised controlled trial." Indian Journal of Anaesthesia 68, no. 4 (2024): 348–53. http://dx.doi.org/10.4103/ija.ija_920_23.

Full text

Abstract:

Background and Aims: There is limited data on the effects of norepinephrine on neonatal outcomes and maternal complications relative to other vasopressors. The study aimed to compare neonatal outcomes and maternal complications after bolus intravenous doses of phenylephrine and norepinephrine for post-spinal hypotension in elective caesarean section women. Methods: This randomised study was done on 100 elective caesarean section women under spinal anaesthesia. Block randomisation divided women into two groups to receive intravenous phenylephrine 50 μg bolus (Group A) or norepinephrine 5 μg bol

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!