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Prochásková, Jana. "Analytické CRM - přehled trhu a trendy." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-15566.
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Analytical CRM is a consistent suite of analytical applications that processes customer data stored in various information systems. The results are used to measure, predict and optimize customer relationships. The CRM applications market is growing despite the economic turmoil. The major trends are: CRM as a service, focus on customer retention and loyalty and last but not least achieving cost savings by effective targeting of marketing activities. The purpose of this paper is to define the business architecture of CRM systems and analytical CRM, analysis of the market and its trends, introduction of Good Data's approach to customer analytics and suggestions for possible extension of their Customer Analytics service.
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Šťavíková, Martina. "Analytical CRM: A Tool How To Manage Company's Profitability." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-12632.
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Cílem práce je nastínit možnosti využití analytického CRM k zvyšování ziskovosti společnosti. Analytický CRM se zabývá analýzou zákaznických dat, které slouží jako podpora pro operativní a strategické rozhodování firmy. Teoretická část práce se zabývá různými způsoby segmentace zákazníků, zákaznickými metrikami a způsoby, jak si udržet dobré zákazníky ve společnosti. Pro ucelený obraz o analytickém CRM také nastiňuje jeho technickou stránku, ve které popisuje nejčastěji využívané techniky při získávání dat. Praktická část práce byla vyhotovena ve spolupráci se společností Makro Cash & Carry. Popisuje nejdůležitější změny, které byly podniknuty k přeměně Makra z produktově na zákaznicky orientovanou společnost, a podrobněji se věnuje práci kontrolorů, jež se analytickým CRM ve firmě zabývají.
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Zvolánek, Tomáš. "Využití BI v řízení vztahů se zákazníky." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-124680.
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Thesis deals with systems for customer relationship management (CRM) and possibility of their expansion and extension using technologies of Business Intelligence (BI). The work focuses on a specific part of CRM - the so-called "analytical CRM" (aCRM). aCRM is examined comprehensively, i.e. in the whole range - from its history and reasons for use, through the problematic relations to other areas of business intelligence. Specification and realization of example aCRM using BI technology is included.
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Maňáková, Helena. "Kritéria úspěchu CRM ve formě SaaS v ČR." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-15817.
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Customer relationship management includes all the sophisticated methodologies. It is a comprehensive way to manage the relationships which company has with its customers. There is a fierce competiton between companies, small businesses have to compete on equal terms with large organizations. This situation leads to discussion about customer oriented approach and diligence to prevent the loss of customer portfolio. Increase in the knowledge of customers is a key point of success. Information technology boosts customer relationship management. Companies face expensiveness of technologies and they try to find cheaper and more reachable solution. To find and evaluate criteria of success of CRM Software-as-a-Service in Czech Republic is the objective of my thesis. The goal is to define a method on how to find aspects of success, to research and to evaluate the results. Thesis contains insight into levels of CRM, summary of criteria of CRM choice, description of SaaS technology, research, results and final conclusion.
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Wübben, Markus. "Analytical CRM developing and maintaining profitable customer relationships in non-contractual settings /." Wiesbaden : Gabler, 2009. http://site.ebrary.com/id/10281287.
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Wübben, Markus. "Analytical CRM : developing and maintaining profitable customer relationships in non-contractual settings /." Wiesbaden : Gabler, 2008. http://d-nb.info/989809811/04.
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Cazarini, Aline. "Auxílio do Data Warehouse e suas ferramentas à estratégia de CRM analítico." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/18/18140/tde-06052016-143213/.
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Atualmente, uma das grandes vantagens competitivas que uma empresa possui em relação a seu concorrente é a informação sobre seu cliente. As estratégias de Customer Relationship Management (CRM), propiciam o profundo conhecimento do cliente, para que a empresa possa tratá-lo de forma personalizada e reconhecê-lo como seu principal patrimônio. Segundo TAURION (2000) e DW BRASIL (2001), para suportar essa tecnologia, é necessário que as empresas possuam um repositório de dados históricos de clientes. O Data Warehouse (DW) possui diversas características que utilizam, de forma adequada e eficiente, ferramentas de desenvolvimento de modernos bancos de dados. Através da ferramenta Data Mining (DM), é possível descobrir novas correlações, padrões e tendências entre informações de uma empresa pela extração e análise dos dados do DW. A análise dos dados também pode ser feita através de sistemas On Line Analytical Proccess (OLAP), os quais ajudam analistas a sintetizar informações sobre as empresas, por meio de comparações, visões personalizadas, análise histórica e projeção de dados em vários cenários. Diante deste contexto, parece possível afirmar que o DW, juntamente com o OLAP, podem proporcionar grande suporte à estratégia de CRM. Desta forma, esta pesquisa apresenta como objetivo identificar e analisar as principais contribuições que o DW e suas ferramentas podem dar à estratégia CRM Analítico.Nowadays, the great competitive advantage that a company possesses in relation to your competitor is the information about its customer. The strategies of Customer Relationship Management (CRM) provide deep knowledge about the customer, so that the company can treat them in a personalized way and it recognizes them as its main patrimony. According to TAURION (2000) and DW BRASIL (2001), to support that technology, it is necessary that the companies possess a repository of customers\' historical data. Data Warehouse (DW) possesses several characteristics that use, in appropriate and efficient way, tools of development of modern databases and, through the too Data Mining (DM) discovers new correlations, pattems and tendencies among information of a company, for the analysis of the data of DW. The analysis of the data can also be made through the systems On Line Analytical Proccess (OLAP), which help analysts and executives to synthesize information on the companies, by means of comparisons, personalized visions, historical analysis and projection of data in several sceneries. In this context, it can be stated that DW and DM can provide great support to the strategy of CRM. Thus, this work presents as objective to identify the main contributions that DW and their tools can give to the strategy of Analytical CRM.
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Černý, Jiří. "Návrh zákaznické databáze." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228342.
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Diploma deals with project managament of market survey which is realized by small Czech trading company. Step by step it attends to questionaire design and how to use it, definition of information minimum, managing of market survey, design of information system modification, data processing by descriptive statistics usage.
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Демидова, Р. Э., and R. E. Demidova. "Автоматизация бизнес-процесса по работе с клиентами с применением CRM-системы : магистерская диссертация." Master's thesis, б. и, 2020. http://hdl.handle.net/10995/93437.
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В современном мире рынок фотографических услуг развивается семимильными шагами. Фотосалоны и фотостудии особенно актуальны среди начинающих бизнесменов. Чтобы повысить продажи, многие компании все чаще предлагают возможность записать клиента онлайн с помощью CRM. CRM-система актуальна по разным причинам: развитие бизнес-процессов, роли интернета и использование мобильных устройств в бизнесе, развитие и удешевление технологий обработки данных и ИТ-инфраструктуры. И, конечно же, большую роль сыграл тот факт, что технические возможности CRM-систем достигли совершенства. Они позволяют отследить путь покупателя с момента первого контакта с ним для перепродажи. Она создает технологию продаж, связывая рекламу, аналитические инструменты и саму систему продаж в единую систему. Результаты выпускной квалификационной работы будут использованы в фотостудии при внедрении CRM-системы AppEvent.In the modern world, the photographic services market is developing by leaps and bounds. Photo salons and photo studios are especially relevant among novice businessmen. To boost sales, many companies are increasingly offering the option to sign up a customer online using CRM. The CRM system is relevant for various reasons: the development of business processes, the role of the Internet and the use of mobile devices in business, the development and reduction of the cost of data processing technologies and IT infrastructure. And, of course, the fact that the technical capabilities of CRM systems have reached perfection played an important role. They allow you to track the path of the buyer from the moment of the first contact with him for resale. It creates sales technology by linking advertising, analytical tools and the sales system itself into a single system. The results of the final qualifying work will be used in the photo studio when implementing the AppEvent CRM system.
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Ferguson, Graham. "The effectiveness of cross-selling as a relationship marketing initiative : an exploration of analytical and commonsense prediction." UWA Business School, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0196.
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[Truncated abstract] Relationship marketing and some of its associated strategies, including customer relationship management (CRM), is an approach to marketing that is increasingly recognised as important by researchers and marketers. The approach suggests that marketers should focus on developing and maintaining strong relationships with existing customers in order to increase customer lifetime value (CLV) and to reduce the costs associated with constantly acquiring new customers. Advocates promote increased revenue per customer, increased products per customer (customer share), lower customer churn (higher retention) and increased chance that loyal customers will advocate on behalf of the organisation (positive word of mouth), as just some of the benefits of building relationships. While the concept of developing stronger relationships with customers appears convincing; the successful implementation of relationship marketing & CRM initiatives has been a challenge for many enterprises. There are many reasons cited for this including differing benchmarks for success, the range of relationship marketing activities available to marketers, customer differences and how marketers choose to model customer response. To cut through this complexity and to contribute to the field, the current study was carried out to explore, in detail, a single relationship marketing initiative being implemented in a large consumer oriented organisation. The goals of the current study were to see whether the introduction of a cross-selling initiative (CSI) helped front line employees to cross-sell additional products to existing customers during face-to-face interactions and whether the technique used to predict product adoption influenced the effectiveness of those cross-selling activities. Cross-selling refers to the promotion of additional products to existing customers. .... It was considered likely that retail employees would be more confident if they received a specific cross-selling recommendation for a customer and that the increased confidence would lead to increased cross-selling activity and better results. The results confirmed that: Retail employees were more likely to approach a customer with a cross-sell offer if they had a specific recommendation for that customer. Cross-sell offers based upon those recommendations were more likely to be successful. Logistic regression was a better technique for identifying customers likely to adopt the product than anecdotal modelling approaches. The current study makes an important contribution to marketers considering or engaging in customer relationship marketing by confirming the effectiveness of CSIs. Based upon the results, CSIs appear to offer marketers an effective tool to increase customer share thereby increasing revenue and potentially increasing customer loyalty, tenure and profitability. The study also illustrates that effective modeling reduces the chance of making superfluous cross-selling offers to customers thereby reducing the cost of cross-selling, enhancing the confidence of retail employees and minimising the risk of damaging existing relationships. Overall, the study illustrates that the potential for CSIs as a relationship marketing tool is substantial and should not be underestimated.
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Dudek, Martin. "Trh CRM systémů a jeho vývoj." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-4884.
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The main aim of this diploma thesis is to create an overview of analytic CRM systems which are offered in the Czech Republic with the emphasis on systems which can be used for marketing processes of the firms. The overview contains the reflection of new trends in CRM systems and marketing and the development to the future. In the last decade there is a huge development of CRM systems, which are generally known as sales force automation and less as an instrument for marketing management of the companies. Last but not least CRM is mistaken with information systems, even if the CRM concept is known for a lot of years and was developed from marketing, which is very often forgotten. The topic of this diploma thesis is originally view on CRM from marketing perspective and creation of compact view of analytic CRM systems, which are offered in the Czech Republic. Emphasis is put on using of these systems for marketing management and the target is disproving the myths, which are spoken about CRM as well CRM systems. Orientation of this document is mainly on analytic CRM systems, which has the most development in the last decades and can be used very well for marketing functions in companies. There is also a large development of marketing and CRM systems. The target is also making a summary of these trends and makes a hypothesis if CRM systems are developed according the future of marketing, if the CRM systems manage the reaction on this things.
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Monteiro, Lidia Gimenez Simão Macul. "E-CRM e a influência da digital analytics." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/3/3136/tde-13072016-151725/.
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O mercado consumidor passou por diversas transformações ao longo do tempo devido principalmente à evolução tecnológica. A evolução tecnológica proporcionou ao consumidor a possibilidade de escolher por produtos e marcas, e permite a oportunidade de colaborar e influenciar a opinião de outros consumidores através do compartilhamento de experiências, principalmente através da utilização de plataformas digitais. O CRM (gerenciamento do relacionamento com o consumidor) é a forma utilizada pelas empresas para conhecerem o consumidor e criar um relacionamento satisfatório entre empresa e consumidor. Esse relacionamento tem o intuito de satisfazer e fidelizar o consumidor, evitando que ele deixe de consumir a marca e evitando que ele influencie negativamente outros consumidores. O e-CRM é o gerenciamento eletrônico do relacionamento com o consumidor, que possui todas as tradicionais características do CRM, porém com o incremento do ambiente digital. O ambiente digital diminuiu a distância entre pessoas e empresas e se tornou um meio colaborativo de baixo custo de interação com o consumidor. Por outro lado, este é um meio onde o consumidor deixa de ser passivo e se torna ativo, o que o torna capaz de influenciar não só um pequeno grupo de amigos, mas toda uma rede de consumidores. A digital analytics é a medição, coleta, análise e elaboração de relatórios de dados digitais para os propósitos de entendimento e otimização da performance em negócios. A utilização de dados digitais auxilia no desenvolvimento do e-CRM através da compreensão do comportamento do consumidor em um ambiente onde o consumidor é ativo. O ambiente digital permite um conhecimento mais detalhado dos consumidores, baseado não somente nos hábitos de compra, mas também nos interesses e interações. Este estudo tem como objetivo principal compreender como as empresas aplicam os conceitos do e-CRM em suas estratégias de negócios, compreendendo de que forma a digital analytics contribui para o desenvolvimento do e-CRM, e compreendendo como os fatores críticos de sucesso (humano, tecnológico e estratégico) impactam na implantação e desenvolvimento do e-CRM. Quatro empresas de diferentes segmentos foram estudadas através da aplicação de estudo de caso. As empresas buscam cada vez mais explorar as estratégias de e-CRM no ambiente digital, porém existem limitações identificadas devido à captação, armazenamento e análise de informações multicanais, principalmente considerando os canais digitais. Outros fatores como o apoio da alta direção e a compreensão de funcionários para lidar com estratégias focadas no consumidor único também foram identificados neste estudo. O estudo foi capaz de identificar as informações mais relevantes para a geração de estratégias de gerenciamento eletrônico do relacionamento com o consumidor e identificou os aspectos mais relevantes dos fatores críticos de sucesso.The consumer market has undergone several transformations over time mainly due to technological developments. Technological progress has given the consumer a choice of products and brands, allowing the opportunity to collaborate and influence the opinion of other consumers through the sharing of experiences, specially by the use of digital platforms. The CRM (customer relationship management) is the form used by companies to know the consumer and establish a satisfactory relationship between both. This relationship aims to satisfy and retain consumers, preventing it ceases to consume the brand and preventing it negatively influence on others. The e-CRM is the electronic management of the relationship with the consumer, which has all the traditional CRM features, which increase the digital environment. The digital environment reduced the distance between consumer and companies becoming a collaborative low-cost way of interaction with the consumer. On the other hand, this is a medium where the consumer is no longer passive and becomes active, which makes it able to influence not only a small group of friends, but a whole network of consumers. The digital analytics is the measurement, collection, analysis and preparation of digital data reports for the purposes of understanding and optimizing business performance. The use of digital data helps in the development of e-CRM through understanding consumer behavior in an environment where the consumer is active. The digital environment allows a more detailed knowledge of consumers, based not only on buying habits, but also on the interests and interactions. This study aims to understand how companies apply the concepts of e-CRM in their business strategies, including how the digital analytics contributes to the development of e-CRM, and understanding how the critical success factors (human, technological and strategic) impact in the implementation and development of e-CRM. Four companies from different segments were studied through study case application. Nowadays, Companies are increasingly looking to explore the e-CRM strategies in the digital environment, but there are limitations identified due to capture, storage and analysis of multi-channel information, especially considering digital channels. Other factors were also identified in this study, such as the support of senior management and the understanding of employees to deal with strategies focused on single consumer. The study was able to identify the most relevant information for the generation of electronic management strategies relationship with the consumer and identified the most relevant aspects of the critical success factors.
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Nebřenský, Aleš. "Analytické CRM v bankovnictví." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-6444.
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The thesis studies the topic of Business Intelligence applications specialized to enhance the analytical, planning and control capabilities of commercial banks in areas such as marketing, sales and customer care. The goal of the diploma work is to give a complex view on analytical CRM in the context of banking industry, to analyze the solution from different perspectives and to design functions, processes and data corresponding to a business model of commercial banking. The theoretical part of the work investigates the customer relationship management strategy, general principles of relationship marketing, current situation in the area of Customer Intelligence and keystones of IS/ICT applications which are applicable to implement the CRM strategy. The following chapters deal with the actual development in Czech banking industry, banking activities and IS/ICT application architecture in the context of banking industry. The main part of the work is focused on analysis and design of functions, processes and data of analytical CRM in the context of banking industry. The results of the analysis suggest implementing a propensity to buy model as an analytical CRM function applicable to manage customer acquisition and customer selection for direct marketing campaigns. Similarly, a function providing the probability of customer churn can be of great value for activities aimed at customer retention. The thesis contributes to the existing literature by designing input variables for propensity to buy modeling, customer retention modeling and customer segmentation. Additionally, the work introduces process models which define the main steps of data analysis and also the performance metrics for these processes. Finally, the part dedicated to data principles of analytical CRM contributes by designing key customer data aggregations and by analyzing different possibilities of data layer integration within the IS/ICT architecture of commercial banks.
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Wang, Qinke. "Analytical methods for VLSI module placement." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3211381.
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Thesis (Ph. D.)--University of California, San Diego, 2006.Title from first page of PDF file (viewed June 13, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 126-139).
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Bandegi, Sanaz. "INTERACTION OF FLUORESCENT LIPID DYES WITH LIPID VESICLES AND SUPPORTED LIPID BILAYERS AND THEIR APPLICATIONS." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/584744.
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ChemistryPh.D.
Lipophilic dye probes are widely used for labelling of cells, organelles, liposomes, viruses and lipoproteins. The lipophilic dye diffuses in the membrane and stains the cell and cells even tolerate the lipophilic dye in high concentration. The fluorescence of styryl dyes increases after insertion into the hydrophobic environment of the lipid membrane compared their fluorescence in the aqueous phase solution. The alkyl chains of the fluorescent styryl dye probe insert into membranes and are used to understand their biophysical properties and their behavior in lipid bilayers. The mechanism of incorporation of the dyes into cell membranes, or vesicle model systems, is not resolved. In this study we used a modified dialkylaminostyryl fluorescent lipid, 4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide (DiA), replacing the I- counterion with the Cl- anion to make DiA-Cl increase hydration of the polar head and to enable self-assembling in water and formation of vesicles. Vesicles composed of DMPC (1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine)/DiA, DPPC (1,2-dipalmitoyl-sn-glycero-3- phosphatidylcholine) /DiA, DSPC (1,2-distearoyl-sn-glycero-3- phosphatidylcholine) /DiA, DMPE (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine)/DiA, DPPE (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine)/DiA and DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine)/DiA have been prepared in mole ratios between 100/0 to 0/100, in order to investigate the effects of chain length and headgroup type on chain packing and phase separation in these mixed amphiphilic systems, using nanocalorimetry, dynamic light scattering and fluorescence data, as well as confocal laser scanning microscopy (CLSM) and cryo-transmission electron microscopy (Cryo-TEM). In addition, we report the self-assembly of DiA-Cl, to form H-aggregates of lipid bilayers in aqueous solution, beyond a critical vesicle concentration. Lipid bilayers can be fused onto silica nanoparticles (NPs) to form supported lipid bilayer (SLB)-NPs. (SLB)-NPs have a varous interdisciplinary applications from medicine to environmental fields and agriculture sciences. Here, the lipids on the nanoparticles were used for two applications. One was to adsorb polycyclic aromatic hydrocarbons (PAHs) from the environment and the other was as vehicles for foliar delivery of nutrients to plants. Silica SLB nanoparticles can increase the solubility of Benzo[a]Pyrene (BaP) in order to extract the BaP from soil for in situ biodegradation. Initial studies were begun on the effect of foliar application of silica SLBs nanoparticles on plants. The SLBs to be used were prepared using both 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and DiA, in order to determine whether the lipid increased the entry of the silica into the plant leaves and whether the lipids also entered.
Temple University--Theses
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Varma, Deepti. "EVALUATION OF THE OXIDATIVE METABOLITES OF ARACHIDONIC ACID AND THEIR IMPLICATION IN THE PROGRESSION OF INFLAMMATORY DISEASES: HYPERTENSION AND RHEUMATOID ARTHRITIS." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/282122.
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ChemistryPh.D.
Inflammation is implicated in diseases such as hypertension and rheumatoid arthritis (RA). A mechanistic understanding of inflammatory processes as it relates to the disease state and injury needs to be developed. Specifically, the role and modulation of inflammation needs to be assessed, as well as the mechanism that produces arachidonic acid (AA) metabolites (eicosanoids). Eicosanoids are specific biomarkers of inflammation. Their biosynthesis from arachidonic acid can be catalyzed by either free radicals or enzymes such as lipoxygenases (LOX), cyclooxygenase-2 (COX-2) and cytochrome P450. Depending on the pathway or parent molecule, different distributions of eicosanoids are found. The oxidation of AA gives hydroxyeicosatetraenoic acids (HETEs), dihydroxyeicosatetraenoic acids (DHETEs), epoxyeicosatetraenoic acids (EETs), prostaglandins (PGs), isoprostanes (Isops) and thromboxanes (TXs). It is our hypothesis that AA metabolites will help in understanding the progression of inflammatory diseases. To confirm this hypothesis, analytical methods including HPLC-UV and LC-MS were developed. The developed and validated HPLC method was applied to study the effect of acute exercise on prostanoids in hypertensive African American subjects. It was our theory that urinary 6-keto PGF1&alpha and 11-dehydro TXB2 can be used to assess the role of exercise in hypertension. Moreover, we assume that 8-iso PGF2 levels can be used as an indicator to determine the relationship of oxidative stress and endothelial dysfunction in hypertension. The HPLC method involved separating urinary 8-iso PGF2, PGE2, PGD2, PGF2, 6-keto PGF1&alpha and 11-dehydro TXB2 on a SymmetryShield Rp18 column (250mm ¡Á 4.6mm) by an isocratic elution of 17 mM phosphoric acid and acetonitrile in the ratio of 65:35 and at a flow rate of 1.3 ml/min. The wavelength used for detection was 196 nm. Specificity was confirmed by LC-MS. The method was fully validated and was found to be having sufficient sensitivity (limit of quantification - 7.5 ng - 30 ng) for many biological matrices and applications. The accuracy and precision were within bioanalytical method validation limits (90.3 to 112.8 % and RSD < 10%, respectively) and the method was linear over three orders of magnitude. In addition, a HPLC-UV method for the simultaneous determination of urinary creatinine and prostanoids was also developed and validated as it is necessary to monitor creatinine levels in addition to biomarkers when the measurement is done in urine. The method was found to be linear over three orders of magnitude and is sensitive enough for the analysis of creatinine and prostanoids in urine. The advantage of this method was that one can determine the levels of these prostanoids normalized by urinary creatinine in a single analysis and in less than 17 min. The LC- ESI (electrospray ionization) MS method, on the other hand was used to determine the role of HETEs in the initiation, progression and resolution phases of inflammation in RA. It is our assumption that 12/15 HETE can be used as novel targets for the treatment of RA. The separation was performed on a C18 column using a gradient elution of 0.1% formic acid in water and 0.1% formic acid in acetonitrile. The flow rate was 1 ml/min and the run time was 75 mins. The method was found to be specific, sensitive and precise. This LCMS method was also used to develop a retention model for complex regioisomers. Quantitative structure- (chromatographic) retention relationship (QSRR) was used to develop a predictive retention model for fatty acid metabolites. Retention behaviors of the lipid biomarkers were characterized by application of QSRR analysis utilizing Austin Model 1 mode semi-empirical computations. The retention data of these fatty acids were obtained from an RP-HPLC method utilizing a Symmetry C18 column under gradient elution. Molecular descriptors that take into account the polarity; chemical reactivity and hydrophobicity of the analytes were calculated using the semi-empirical AM1 mode. It is our hypothesis that QSRR will give insight into molecular mechanism of separation of lipid biomarkers operating in a given chromatographic system and can predict retention of a new analyte and/or to identify unknown analytes.
Temple University--Theses
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Haleem, Kirolos. "Comprehensive Analytical Investigation of the Safety of Unsignalized Intersections." Doctoral diss., University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2741.
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According to documented statistics, intersections are among the most hazardous locations on roadway systems. Many studies have extensively analyzed safety of signalized intersections, but did not put their major focus on the most frequent type of intersections, unsignalized intersections. Unsignalized intersections are those intersections with stop control, yield control and no traffic control. Unsignalized intersections can be differentiated from their signalized counterparts in that their operational functions take place without the presence of a traffic signal. In this dissertation, multiple approaches of analyzing safety at unsignalized intersections were conducted. This was investigated in this study by analyzing total crashes, the most frequent crash types at unsignalized intersections (rear-end as well as angle crashes) and crash injury severity. Additionally, an access management analysis was investigated with respect to the different median types identified in this study. Some of the developed methodological techniques in this study are considered recent, and have not been extensively applied. In this dissertation, the most extensive data collection effort for unsignalized intersections was conducted. There were 2500 unsignalized intersections collected from six counties in the state of Florida. These six counties were Orange, Seminole, Hillsborough, Brevard, Leon and Miami-Dade. These selected counties are major counties representing the central, western, eastern, northern and southern parts in Florida, respectively. Hence, a geographic representation of the state of Florida was achieved. Important intersections' geometric and roadway features, minor approach traffic control, major approach traffic flow and crashes were obtained. The traditional negative binomial (NB) regression model was used for modeling total crash frequency for two years at unsignalized intersections. This was considered since the NB technique is well accepted for modeling crash count data suffering from over-dispersion. The NB models showed several important variables affecting safety at unsignalized intersections. These include the traffic volume on the major road and the existence of stop signs, and among the geometric characteristics, the configuration of the intersection, number of right and/or left turn lanes, median type on the major road, and left and right shoulder widths. Afterwards, a new approach of applying the Bayesian updating concept for better crash prediction was introduced. Different non-informative and informative prior structures using the NB and log-gamma distributions were attempted. The log-gamma distribution showed the best prediction capability. Crash injury severity at unsignalized intersections was analyzed using the ordered probit, binary probit and nested logit frameworks. The binary probit method was considered the best approach based on its goodness-of-fit statistics. The common factors found in the fitted probit models were the logarithm of AADT on the major road, and the speed limit on the major road. It was found that higher severity (and fatality) probability is always associated with a reduction in AADT, as well as an increase in speed limit. A recently developed data mining technique, the multivariate adaptive regression splines (MARS) technique, which is capable of yielding high prediction accuracy, was used to analyze rear-end as well as angle crashes. MARS yielded the best prediction performance while dealing with continuous responses. Additionally, screening the covariates using random forest before fitting MARS model was very encouraging. Finally, an access management analysis was performed with respect to six main median types associated with unsignalized intersections/access points. These six median types were open, closed, directional (allowing access from both sides), two-way left turn lane, undivided and mixed medians (e.g., directional median, but allowing access from one side only). Also, crash conflict patterns at each of these six medians were identified and applied to a dataset including median-related crashes. In this case, separating median-related and intersection-related crashes was deemed significant in the analysis. From the preliminary analysis, open medians were considered the most hazardous median type, and closed and undivided medians were the safest. The binomial logit and bivariate probit models showed significant median-related variables affecting median-related crashes, such as median width, speed limit on the major road, logarithm of AADT, logarithm of the upstream and downstream distances to the nearest signalized intersection and crash pattern. The results from the different methodological approaches introduced in this study could be applicable to diagnose safety deficiencies identified. For example, to reduce crash severity, prohibiting left turn maneuvers from minor intersection approaches is recommended. To reduce right-angle crashes, avoiding installing two-way left turn lanes at 4-legged intersections is essential. To reduce conflict points, closing median openings across from intersections is recommended. Since left-turn and angle crash patterns were the most dominant at undivided medians, it is recommended to avoid left turn maneuvers at unsignalized intersections having undivided medians at their approach. This could be enforced by installing a left-turn prohibition sign on both major and minor approaches.Ph.D.
Department of Civil and Environmental Engineering
Engineering and Computer Science
Civil Engineering PhD
18
Rosquete, Ramon J. "Wakeboards : correlation of cognitive and analytical data on fins." Honors in the Major Thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1045.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Engineering and Computer Science
Mechanical Engineering
19
Fernando, L. Greshan. "Development of an analytical model for electrochemical machining (ECM) of an axisymmetric disk." Ohio : Ohio University, 1999. http://www.ohiolink.edu/etd/view.cgi?ohiou1175884893.
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Pesavento, Elena. "Analytical evaluation and application of tests for cointegration /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9984808.
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Baxter, Mathew. "Analytical solutions to nonlinear differential equations arising in physical problems." Doctoral diss., University of Central Florida, 2014. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6247.
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Nonlinear partial differential equations are difficult to solve, with many of the approximate solutions in the literature being numerical in nature. In this work, we apply the Homotopy Analysis Method to give approximate analytical solutions to nonlinear ordinary and partial differential equations. The main goal is to apply different linear operators, which can be chosen, to solve nonlinear problems. In the first three chapters, we study ordinary differential equations (ODEs) with one or two linear operators. As we progress, we apply the method to partial differential equations (PDEs) and use several linear operators. The results are all purely analytical, meaning these are approximate solutions that we can evaluate at points and take their derivatives.
Another main focus is error analysis, where we test how good our approximations are. The method will always produce approximations, but we use residual errors on the domain of the problem to find a measure of error.
In the last two chapters, we apply similarity transforms to PDEs to transform them into ODEs. We then use the Homotopy Analysis Method on one, but are able to find exact solutions to both equations.Ph.D.
Doctorate
Mathematics
Sciences
Mathematics
22
Ansong, Omari E. "Preparation and Evaluation of Novel Initiators for the Thermally Mild Living and Controlled Free Radical Polymerization of Methacrylates: Potential Application in Dental Composite Resins." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/17521.
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ChemistryPh.D.
A number of nitroxide adducts and N-acyloxytrialkylammonium salts were prepared, isolated, characterized and evaluated as initiators for the controlled and living free radical polymerization of methacrylate and dimethacrylate monomers under mildly thermal and photochemical conditions. The initiators and polymerization methods that were developed could potentially be used for improving resins employed in dental applications. Using very easy synthesis strategies, the following nitroxide initiators were prepared in high purity, isolated and characterized: 1-Benzoylperoxy-2,2,6,6-tetramethyl-piperidine (BPO/TEMPO), 1-(2'-Cyano-2'-propoxy)-2,2,6,6-tetramethylpiperidine (AIBN/TEMPO), 1,1-ditertbutyl-1-(1-methyl-1-cyanoethoxy)-amine (AIBN/DBN), 1,1-ditertbutyl-1-(benzoylperoxy)-amine (BPO/DBN) and 2,2,6,6,-tetramethyl-4-oxo-1-(1-methyl-1-cyanoethoxy)-piperidine (AIBN/4-OXO-TEMPO). Using H2SO4 additive and an improved unimolecular initiation in nitroxide mediated polymerization, living and controlled polymerization of methyl methacrylate (MMA), tri-ethylene glycol dimethacrylate (TEGDMA) and ethoxylated bisphenol A dimethacrylate (EBPADMA) were accomplished, for the first time ever for most of the initiators. Linear polymers (PMMA) were produced in high yield (93 %) under mildly thermal conditions (T = 70 oC) and with excellent attributes: (PDI = 1.04-1.26), Mn (87000), Tg (122-128 oC), Td (290-410 oC). Highly crosslinked polymers, poly(TEGDMA) and poly(EBPADMA), were produced in high yield (100 %) with Td (350-400 oC). The initiators were stable for a year and half at 0 oC. Two routes were investigated for the preparation of N-acyloxytrialkylammonium salts. The more efficient of these routes was used to make several novel analogs of the salts. The salts were evaluated for the free radical polymerization of MMA, TEGDMA and EBPADMA under mildly thermal (T = 60 oC) conditions with and without H2SO4 additive. Polymerization rate, yield and polymer attributes all improved upon application of H2SO4 additive. PMMA was produced with excellent attributes (PDI = 1.01-1.06), Mn (96,000-122000), Td (330-385) and Tg (127-134). Highly crosslinked poly(TEGDMA) and poly(EBPADMA) were produced with Td ranges of 300-374 oC and 375-411 oC respectively.
Temple University--Theses
23
Burkett, Jason Lee. "BENCHMARK STUDIES FOR STRUCTURAL HEALTH MONITORING USING ANALYTICAL AND EXPERIMENTAL MODELS." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2660.
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The latest bridge inventory report for the United States indicates that 25% of the highway bridges are structurally deficient or functionally obsolete. With such a large number of bridges in this condition, safety and serviceability concerns become increasingly relevant along with the associated increase in user costs and delays. Biennial inspections have proven subjective and need to be coupled with standardized non-destructive testing methods to accurately assess a bridge's condition for decision making purposes. Structural health monitoring is typically used to track and evaluate performance, symptoms of operational incidents, anomalies due to deterioration and damage during regular operation as well as after an extreme event. Dynamic testing and analysis are concepts widely used for health monitoring of existing structures. Successful health monitoring applications on real structures can be achieved by integrating experimental, analytical and information technologies on real life, operating structures. Real-life investigations must be backed up by laboratory benchmark studies. In addition, laboratory benchmark studies are critical for validating theory, concepts, and new technologies as well as creating a collaborative environment between different researchers. To implement structural health monitoring methods and technologies, a physical bridge model was developed in the UCF structures laboratory as part of this thesis research. In this study, the development and testing of the bridge model are discussed after a literature review of physical models. Different aspects of model development, with respect to the physical bridge model are outlined in terms of design considerations, instrumentation, finite element modeling, and simulating damage scenarios. Examples of promising damage detection methods were evaluated for common damage scenarios simulated on the numerical and physical models. These promising damage indices were applied and directly compared for the same experimental and numerical tests. To assess the simulated damage, indices such as modal flexibility and curvature were applied using mechanics and structural dynamics theory. Damage indices based on modal flexibility were observed to be promising as one of the primary indicators of damage that can be monitored over the service life of a structure. Finally, this thesis study will serve an international effort that has been initiated to explore bridge health monitoring methodologies under the auspices of International Association for Bridge Maintenance and Safety (IABMAS). The data generated in this thesis research will be made available to researchers as well as practitioners in the broad field of structural health monitoring through several national and international societies, associations and committees such as American Society of Civil Engineers (ASCE) Dynamics Committee, and the newly formed ASCE Structural Health Monitoring and Control Committee.M.S.
Department of Civil and Environmental Engineering
Engineering and Computer Science
Civil Engineering
24
Hill, Terrance J. "ANALYTICAL AND EXPERIMENTAL CHARACTERIZATION OF SOQPSK AND MULTI-H CPM IN A MULTIPATH CHANNEL." International Foundation for Telemetering, 2001. http://hdl.handle.net/10150/606446.
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International Telemetering Conference Proceedings / October 22-25, 2001 / Riviera Hotel and Convention Center, Las Vegas, NevadaShaped Offset QPSK (SOQPSK) has been shown to be nearly identical in performance to Feher-patented FQPSK, which is the Advanced Range Telemetry (ATRM) program's Tier I waveform. Multi-h CPM has been selected as the ARTM Tier II waveform, because it offers 50% better spectral efficiency than the Tier I waveform. Both the Tier I and Tier II waveforms must operate in a multipath channel in order to meet the range community's telemetry requirements. This paper presents an analytical and experimental characterization of SOQPSK and Multi-h CPM in the presence of multipath. Quantitative results are presented which demonstrate the relative robustness of the ARTM Tier I and Tier II waveforms, in channels representative of a typical range environment.
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Panigrahi, Debananda. "Developing analytical tools for a local agency pavement management system /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1426091.
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Liang, Xiaoping. "Analytical modeling of short channel effects in double gate MOSFET." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3204577.
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Thesis (Ph. D.)--University of California, San Diego, 2006.Title from first page of PDF file (viewed April 4, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Paul, Bryan. "Analytical And Experimental Study Of Monitoring For Chain-Like Nonlinear Dynamic Systems." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5686.
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Inverse analysis of nonlinear dynamic systems is an important area of research in the ?eld of structural health monitoring for civil engineering structures. Structural damage usually involves localized nonlinear behaviors of dynamic systems that evolve into different classes of nonlinearity as well as change system parameter values. Numerous parametric modal analysis techniques (e.g., eigensystem realization algorithm and subspace identification method) have been developed for system identification of multi-degree-of-freedom dynamic systems. However, those methods are usually limited to linear systems and known for poor sensitivity to localized damage. On the other hand, non-parametric identification methods (e.g., artificial neural networks) are advantageous to identify time-varying nonlinear systems due to unpredictable damage. However, physical interpretation of non-parametric identification results is not as straightforward as those of the parametric methods. In this study, the Multidegree-of-Freedom Restoring Force Method (MRFM) is employed as a semi-parametric nonlinear identification method to take the advantages of both the parametric and non-parametric identification methods. The MRFM is validated using two realistic experimental nonlinear dynamic tests: (i) large-scale shake table tests using building models with different foundation types, and (ii) impact test using wind blades. The large-scale shake table test was conducted at Tongji University using 1:10 scale 12-story reinforced concrete building models tested on three different foundations, including pile, box and fixed foundation. The nonlinear dynamic signatures of the building models collected from the shake table tests were processed using MRFM (i) to investigate the effects of foundation types on nonlinear behavior of the superstructure and (ii) to detect localized damage during the shake table tests. Secondly, the MRFM was applied to investigate the applicability of this method to wind turbine blades. Results are promising, showing a high level of nonlinearity of the system and how the MRFM can be applied to wind-turbine blades. Future studies were planned for the comparison of physical characteristic of this blade with blades created made of other material.M.S.
Masters
Civil, Environmental, and Construction Engineering
Engineering and Computer Science
Civil Engineering; Structures and Geotechnical Engineering
28
Kovach, Jessica Lynn. "USING ANALYTICAL METHODOLOGIES TO ASSESS THE ORGANOLEPTIC CHARACTER OF CITRUS ESSENTIAL OIL." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/590546.
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ChemistryPh.D.
Essential oils are natural products used to flavor food and beverages. With the increase in nutrition conscious consumers, manufacturers of food additives and food products are faced with the challenge of making healthy alternatives. In particular, food products going to market with label claims stating reductions in sugar and salt, organic certified, organic compliant, and all natural; moreover the ingredients used in flavors must meet these label claims as well. More often than not, the challenge in using ingredients that follow these requirements is the pricing, the sourcing and the variability among those sources. Variability is common in the ingredients coming from nature such as fruits and plants because the area of cultivation can vary by the soil at the sight of planting and/or the climate in the region. Pricing is also problematic in naturally grown ingredients because it is a matter of supply and demand. Stock could be depleted from natural disasters, disease carrying pest(s), pests that consume the crop, and/or other causes for scarce supply of crop(s). Essential oils are natural byproducts of fruit, peels, and leaves from plants that contribute to flavor formulae for a large variety of food products. Because the essential oils are a crop based commodity, every variety has inherent differences based on the growing conditions and their ripening stages [1]. Nevertheless, each type of oil has marker chemicals that make up the majority of its composition; these marker chemicals have the tendency to degrade over time based on their interaction with light, oxygen exposure, and temperature. For companies that manufacture flavorings, understanding the variability among sources of essential oils as well as the possible degradants of essential oils is valuable information to obtain because it is possible the variants and degradants will negatively impact the flavor profile. Flavor is without question the most important attribute of the food we consume and by default stability of said flavor(s) need to be understood [30]. The content in this dissertation involves the stability analysis of a common essential oil, Oil Mandarin Italian Select, from Citrus Reticulata Blanco. It has known off notes that form from unknown causes. Most common is the plastic note that has formed in carbonated products like soda. Studying this particular essential oil in various conditions is intended to shed light on what those degradants are and under which conditions they form to give mandarin oil an off-note when applied to high acid and carbonated beverage applications. Once the note is reproduced, a correlation between analytical data and sensory interpretation of the oil will be developed. Mandarin essential oil being in the Citrus genus is traditionally analyzed via gas chromatography (GC) because of the high quantities of volatile constituents that give an oil high aroma activity. The volatile fraction of mandarin oil to be studied includes stability of methyl-N-methylanthranilate (MNMA), a major component giving mandarin its distinct grapey character, as well as gamma terpinene, thymol, sinensal, alpha pinene, beta pinene, myrcene, para cymene, alpha terpineol, and beta caryophyllene. Each of these ten compounds contributes to the unique flavor profile of mandarin oils when compared to orange and tangerine essential oils [1]. It was the common knowledge that para cymene can be perceived as rancid in aroma and the many interconversions the terpenes make that cause para cymene formation in Citrus oils, which made monitoring the changes of this chemical in the three stability environments crucial. Attention is being paid to para-cymene, as a specific marker of degradation in Citrus. The data obtained from the applied stability studies were challenging to understand as the marker chemicals are volatile and sensitive to chemical change. In this work the chemical changes and trends were analyzed under various storage conditions. Significant statistical analyses were employed to help define criteria of usability. The analyses were required because of natural variants and apparent inconsistencies of the data. Dixon Q Test and the Z Test were applied to determine outliers. Additionally, the Bland Altman method was applied to compare storage conditions and to determine if this statistical approach could be used to define significant changes in the marker chemical stability. The Bland Altman plots suggest that each component met the statistical limits of agreement, meaning the samplings were not significantly changing, statistically speaking. A final approach to assess the analytical data of the mandarin oil for significant change was the mass balance of each marker chemical from week 0 to week 24. Instrumental fluctuations have an acceptable range of +/- 20% in the industry; hence, a significant change criterion for a chemical in the mass balance must be one that exceeded +/- 20%. Unlike classical statistic methods, the mass balance was indicative that significant change had occurred to the compounds in the three studies. Upon sensory analysis of the oil samples, display of plastic note, oxidation, and overall loss of characteristic mandarin notes, the mass balance was found to correlate best to the significant change detected by sensory evaluation of the oil samplings. Due to the inadequate number of validated methods on Citrus essential oil research and the absence of large groupings of terpenes validated in a unified methodology, reconciliation of mass balance is an underutilized method of assessment in the literature. As a final assessment of the GC method validated, a product containing the selected mandarin oil was analyzed to evaluate the ability of the method to separate the oil components within a significantly more complicated matrix than the initial samples. The method was successful though not all marker chemicals were detected due to their low formulation concentration being below the level of detection of the method. This should not be seen as a failure of the method. For the major components of the essential oil studied, the method was quantitatively successful, meeting industry requirements.
Temple University--Theses
29
Sait, Hani. "Analytical and experimental study of thin film evaporation in heat pipes /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3164540.
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Rodrigues, Eunice Raquel Geraldes de Oliveira. "Desenvolvimento de Micro-sistemas Analíticos em Substratos Poliméricos com Detectores Ópticos Integrados." Tese, Faculdade de Farmácia da Universidade do Porto, 2010. http://hdl.handle.net/10216/63794.
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Rodrigues, Eunice Raquel Geraldes de Oliveira. "Desenvolvimento de Micro-sistemas Analíticos em Substratos Poliméricos com Detectores Ópticos Integrados." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2010. http://hdl.handle.net/10216/63794.
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Huiyong, Wang. "Novel improvements on the analytical chemistry of polycyclic aromatic hydrocarbons and their metabolites." Doctoral diss., University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4621.
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Parent PAH are relatively inert and need metabolic activation to express their carcinogenicity. By virtue of the rich heterogeneous distribution of metabolic products they produce, PAH provide a full spectrum of the complexity associated with understanding the initial phase of carcinogenesis. PAH metabolites include a variety of products such as expoxides, hydroxyl aromatics, quinines, dihydrodiols, dioepoxides, tetrols and water soluble conjugates. During the past decades tremendous efforts have been made to develop bio-analytical techniques that possess the selectivity and sensitivity for the problem at hand. Depending on the complexity of the sample and the relative concentrations of the targeted metabolites, a combination of sample preparation techniques is often necessary to reach the limits of detection of the instrumental method of analysis. The numerous preparation steps open ample opportunity to metabolite loss and collection of inaccurate data. Separation of metabolites has been accomplished via HPLC, capillary electrophoresis (CE) and GC-MS. Unfortunately, the existence of chemically related metabolic products with virtually identical fragmentation patterns often challenges the specificity of these techniques. This dissertation presents significant improvements in various fronts. Its first original component--which we have named solid-phase nano-extraction (SPNE)--deals with the use of gold nanoparticles (Au NPs) as extracting material for PAH. The advantages of SPNE are demonstrated for the analysis of PAH in water samples via both HPLC and Laser-Excited Time-Resolved Shpol'skii Spectroscopy (LETRSS). The same concept is then extended to the analysis of monohydroxy-PAH in urine samples via SPE- HPLC and In-Capillary SPNE-CE. The second original component of this dissertation describes the application of Shpol'skii Spectroscopy to the analysis of polar PAH metabolites.; Polycyclic aromatic hydrocarbons (PAH) are important environmental pollutants originating from a wide variety of natural and anthropogenic sources. Because many of them are highly suspect as etiological agents in human cancer, chemical analysis of PAH is of great environmental and toxicological importance. Current methodology for PAH follows the classical pattern of sample preparation and chromatographic analysis. Sample preparation pre-concentrates PAH, simplifies matrix composition, and facilitates analytical resolution in the chromatographic column. Among the several approaches that exist to pre-concentrate PAH from water samples, the Environmental Protection Agency (EPA) recommends the use of solid-phase extraction (SPE). High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) are the basis for standard PAH identification and determination. Ultraviolet (UV) absorption and room temperature fluorescence detection are both widely used in HPLC, but the specificity of these detectors is modest. Since PAH identification is solely based on retention times, unambiguous PAH identification requires complete chromatographic resolution of sample components. When HPLC is applied to "unfamiliar" samples, the EPA recommends that a supporting analytical technique such as GC-MS be applied to verify compound identification and to check peak-purity HPLC fractions. Independent of the volume of extracted water, the approximate time required to separate and determine the sixteen "priority pollutants" (EPA-PAH) via HPLC is approximately 60min. If additional GC-MS analysis is required for unambiguous PAH determination, the total analysis time will reach 2-3 hours per sample. If the concentrations of target species are found to lie outside the detector's response range, the sample must be diluted and the process repeated. These are important considerations when routine analysis of numerous samples is contemplated.; The outstanding selectivity and sensitivity for the direct analysis of PAH at trace concentration levels has made Shpol'skii spectroscopy a leading technique in environmental analysis. Unfortunately, the requirement of a specific guest-host combination--typically a non-polar PAH dissolved in an n-alkane-- has hindered its widespread application to the field of analytical chemistry. This dissertation takes the first steps in removing this limitation demonstrating its feasibility for the analysis of polar benzopyrene metabolites in alcohol matrixes.ID: 029094381; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Author's name on p. ii appears as Huiyong Wang.; Thesis (Ph.D.)--University of Central Florida, 2010.; Includes bibliographical references (p. 217-232).
Ph.D.
Doctorate
Department of Chemistry
Sciences
33
Siggelkow, Lena. "Analytical and empirical analyses on fixed asset write-offs." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-116920.
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The objective of the International Financial Reporting Standards (IFRS) is to provide useful information to the users of financial statements to assist in making economic decisions. To be useful, information has to be relevant and reliable, but the reliability of information suffers when the guidelines for the reporting of specific issues are not clear and managerial discretion arises. Write-offs are one of those accounting issues that are regularly related to earnings management. By now it is seen as common knowledge that write-offs, especially those on goodwill, do not reflect declines in asset value; rather, they are used as a device to manipulate financial reports. However, there is a striking lack of grounded theoretical research that can confirm this assessment. The aim of this dissertation is to provide valuable analytical and empirical insights on fixed asset write-offs under IFRS. In a first step, the practical implementation of IAS 36 in Europe has to be analyzed, which is best done empirically. Based on the findings from these empirical surveys, the most substantial questions remaining are subject to an in-depth analytical discussion. Since IAS 36 entails different measurement issues that have their origins in finance theory, this dissertation also aims to introduce some basic techniques from theoretical finance to accounting research. Lastly, as the analyses presented in this dissertation do not cover all open questions on fixed asset write-offs, the author hopes to encourage further research on this important topic.
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Sistani, Habiballah. "DESIGN, DEVELOPMENT AND APPLICATION OF ANALYTICAL APPARATUSES FOR LASER ELECTROSPRAY MASS SPECTROMETRY ANALYSIS." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/600064.
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ChemistryPh.D.
With any analytical technique, there are inherent deficiencies that can be improved upon for optimizing sensitivity, ease of analysis, reproducibility, etc. The unifying goal of this work is the design and implementation of apparatuses to improve the capabilities of laser-electrospray hybrid based mass spectrometry techniques, with laser electrospray mass spectrometry (LEMS) serving as the experimental subject for projects discussed in this thesis. In LEMS, ~60 fs laser pulses centered at 800 nm are used to vaporize the analyte from a surface into the gas phase without the need for a matrix. The laser-vaporized analytes are then captured by an electrospray source and detected via a mass spectrometer. The dried droplet technique is the most common method of sample preparation for LEMS analysis where aliquots of sample are deposited onto a substrate followed by drying at room temperature. While the dried droplet technique is convenient, a spatially inhomogeneous distribution of analytes is deposited which results in high laser shot to shot signal variance, consequently resulting in high variances between replicate samples. To increase the homogeneity of the sample deposited, an electrospray deposition (ESD) device was built and used for deposition of samples of Victoria blue on stainless steel or indium tin oxide (ITO) slides. LEMS measurements of the ESD-prepared films on both substrates were comparable and revealed lower average relative standard deviations (RSD) for measurements within-film (20.9%) and between-films (8.7%) in comparison to dried droplets (75.5% and 40.2%, respectively). The mass spectral response for ESD samples on both substrates was linear (R2 > 0.99), enabling quantitative measurements over the selected range of 7.0 × 10−11 to 2.8 × 10−9 mol, as opposed to the dried droplet samples where quantitation was not possible (R2 = 0.56). Another major limitation in all laser-ESI hybrid systems is that the sample must be in close proximity to the mass spectrometer inlet. In order to transfer laser ablated materials via an electrospray source, the electrospray needle must be close enough to the high voltage inlet to produce charge separation, generate a Taylor cone and ultimately, charged droplets. This short distance (on the order of mm) restricts the size and geometry of the samples to be analyzed. This dissertation details the design of a novel remote sampling device for LEMS analysis. The vaporization process takes place inside a controlled gas flow compartment of a sample chamber where a nitrogen carrier gas is applied coaxially to the vaporization plume providing confined radial expansion dynamics of the particles. Vaporized particles are then transported through a tube and enter the nebulizing gas sheath of an electrospray ionization (ESI) needle where capture and post-ionization of the analyte occurs. Analysis of four selected pharmaceutical compounds revealed enhanced sensitivity and improved reproducibility of remote LEMS when compared to conventional LEMS measurements. This dissertation also explores the possibility of using a nanosecond laser as a means to vaporize samples from stainless steel and glass slides for LEMS analysis. Wet samples of myoglobin on stainless steel were successfully vaporized by ns laser pulses while irradiation of myoglobin on glass did not result in vaporization. In a comparison study, fs laser pulses were able to vaporize wet myoglobin from both substrates. To achieve vaporization from glass, surfactant-free gold nanostars (GNS) were successfully used as a matrix for desorption and detection of myoglobin using ns-LEMS. This dissertation also reports the first synthesis of gold nanostars (GNS) exploiting the conversion of dual microplasma generated Au clusters to GNS in aqueous solutions of KAuCl4 containing small amounts of AgNO3, without addition of a surfactant or a stabilizing agent. The single-cell dual microplasma source is also a novel apparatus. Primary experiments using dual microplasma processing yielded various sized spherical gold nanoparticles (AuNPs) with polydispersity index (PDI) of 0.29. By kinetic control of post microplasma reduction, monodispersed nanospheres were produced with PDI of 0.06. An important discovery was the excess amount of hydrogen peroxide produced during microplasma process, making the production of GNS possible.
Temple University--Theses
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Campbell, Katharine. "AN ANALYTICAL UNDERSTANDING OF ADMINISTRATIVE PRACTICES MINIMIZING VICARIOUS TRAUMATIZATION IN DOMESTIC VIOLENCE ORGANIZATIONS I." Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2497.
Full textAbstract:
Working within the field of domestic violence can result in the occurrence of vicarious traumatization. The literature supports that collegial support and supervision are effective tools organizations can implement to assist in minimizing vicarious trauma. This study, guided by constructive self development theory and feminist theory, examines whether the level of vicarious trauma is impacted by knowledge base, collegial support, and supervision. Staff within certified shelters in the state of Florida were surveyed using a research designed instrument and the Trauma and Attachment Belief Scale. A total of 112 participants were recruited using the Tailor Design Method of surveying. Findings indicate that uniquely none of the independent variables significantly impacted vicarious trauma symptoms. However, collectively knowledge base, collegial support and supervision did impact minimizing vicarious trauma. Further, five of the ten subscales of vicarious trauma showed a statistically significant relationship with the independent variables. Implications for domestic violence agencies, practitioners, and future research are drawn.Ph.D.
Other
Health and Public Affairs
Public Affairs PhD
36
Sweet, Erik. "ANALYTICAL AND NUMERICAL SOLUTIONS OF DIFFERENTIALEQUATIONS ARISING IN FLUID FLOW AND HEAT TRANSFER PROBLEMS." Doctoral diss., University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2585.
Full textAbstract:
The solutions of nonlinear ordinary or partial differential equations are important in the study of fluid flow and heat transfer. In this thesis we apply the Homotopy Analysis Method (HAM) and obtain solutions for several fluid flow and heat transfer problems. In chapter 1, a brief introduction to the history of homotopies and embeddings, along with some examples, are given. The application of homotopies and an introduction to the solutions procedure of differential equations (used in the thesis) are provided. In the chapters that follow, we apply HAM to a variety of problems to highlight its use and versatility in solving a range of nonlinear problems arising in fluid flow. In chapter 2, a viscous fluid flow problem is considered to illustrate the application of HAM. In chapter 3, we explore the solution of a non-Newtonian fluid flow and provide a proof for the existence of solutions. In addition, chapter 3 sheds light on the versatility and the ease of the application of the Homotopy Analysis Method, and its capability in handling non-linearity (of rational powers). In chapter 4, we apply HAM to the case in which the fluid is flowing along stretching surfaces by taking into the effects of "slip" and suction or injection at the surface. In chapter 5 we apply HAM to a Magneto-hydrodynamic fluid (MHD) flow in two dimensions. Here we allow for the fluid to flow between two plates which are allowed to move together or apart. Also, by considering the effects of suction or injection at the surface, we investigate the effects of changes in the fluid density on the velocity field. Furthermore, the effect of the magnetic field is considered. Chapter 6 deals with MHD fluid flow over a sphere. This problem gave us the first opportunity to apply HAM to a coupled system of nonlinear differential equations. In chapter 7, we study the fluid flow between two infinite stretching disks. Here we solve a fourth order nonlinear ordinary differential equation. In chapter 8, we apply HAM to a nonlinear system of coupled partial differential equations known as the Drinfeld Sokolov equations and bring out the effects of the physical parameters on the traveling wave solutions. Finally, in chapter 9, we present prospects for future work.Ph.D.
Department of Mathematics
Sciences
Mathematics PhD
37
Coenen, Olivier J. M. D. "Modeling the vestibulo-ocular reflex and the cerebellum : analytical & computational approaches /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9935445.
Full text
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Russell, Gregory T. "Development of an analytical model for pitch link loads of bearingless main rotors." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2007. http://wwwlib.umi.com/cr/syr/main.
Full text
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Rex, Matthew. "ROOM TEMPERATURE FLUORESCENCE SPECTROSCOPY AS A TOOL FOR THE FORENSIC TRACE ANALYSIS OF TEXTILE FIBERS." Doctoral diss., University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4355.
Full textAbstract:
ABSTRACT Trace textile fiber evidence is found at numerous crime scenes and plays an important role in linking a suspect to the respective scene. Several methods currently exist for the analysis of trace fiber evidence. Microscopy provides information regarding the fibers material, color and weave. For more detailed chemical analysis chromatographic methods are employed and for discrimination between dyes, liquid chromatography coupled with mass spectrometry (LC-MS) is currently the method providing the most discrimination. These methods have primarily focused on the dyes used to color the fibers and have not investigated other components that can potentially discriminate among fibers. This dissertation deals with investigations into the fluorescence of the fiber dyes, (contaminants?) and the fibers themselves, as well as methodology for discriminating between fibers using fluorescence. Initial systematic analysis was conducted on dye standards and extracts taken from fibers colored with the respective dyes of interest. Absorbance, excitation and fluorescence spectra were compared between standards and extracts to determine the optimal area of the fiber to investigate: dyes, fluorescent impurities or the whole fiber. High performance liquid chromatography investigations were performed to give detailed information on the number of dye and fluorescent components present in extracts. Our investigations then focused on the best room-temperature fluorescence (RTF) data format for analysis and discrimination of fiber samples. An excitation emission matrix (EEM) was found to give the greatest amount of spectral information and provide the highest level of discrimination. Successful discrimination between non similar and similar fibers was achieved with the aid of Chemometric analysis. The level of discrimination obtained via RTF-EEM spectroscopy was sufficient to differentiate among fibers obtained from two separate cloths of the same material and colored with the same dye reagent. Final studies deal with examining exposure of the fiber to various environmental contaminants. Clothing fibers are typically exposed to myriad numbers of contaminants, from food stains to cigarette smoke. The challenge then becomes detecting fluorescence signals from trace amounts of these environmental contaminants. We demonstrate the detection and classification of polycyclic aromatic hyrdrocarbons (PAH) present on fibers after exposure to cigarette smoke. This dissertation also investigates the change in fluorescence emission after laundering fibers numerous times. The main drawback of chemical analysis of fibers is the destructive nature of the methods. To extract a dye or contaminant from a fiber essentially destroys the evidence. This leaves the investigator without their original sample in the courtroom. This also provides a finite amount of sample for testing and analysis. This is true of chromatographic methods and for the method detailed in this dissertation which makes use of extracts taken from fiber samples. Lastly, we propose an instrumental setup coupling a microscope to a spectrofluorimeter for the purpose of taking EEM directly from a fiber sample. This setup makes use of the superior optics of the microscope for focusing excitation light onto the fiber sample. Initial studies have been performed on extracts from a single textile fiber and EEM collected from said fiber.Ph.D.
Department of Chemistry
Sciences
Chemistry PhD
40
Ferreira, Roberta Borges. "Estratégias analíticas para determinação de fósforo por espectrometria de absorção atômica com fonte contínua de alta resolução /." Araraquara : [s.n.], 2009. http://hdl.handle.net/11449/97846.
Full textAbstract:
Orientador: José Anchieta Gomes NetoBanca: Pedro Vitoriano Oliveira
Banca: Marcia Andreia Mesquita Silva da Veiga
Resumo: Foi desenvolvido um método para a determinação espectrométrica de fósforo em insumos agroindustriais. O método está baseado na determinação por Espectrometria de Absorção atômica com Fonte Contínua de Alta Resolução (HR-CS AAS) utilizando a linha atômica 213,618 nm e bandas de 246,400 nm e 324,616 nm. Foram estudadas as melhores condições para a análise via absorção pelas bandas de PO e da linha de P atômica. Para a primeira, a melhor forma de análise foi utilizar a chama oxidante ar / acetileno, já para a última situação a atomização foi pela utilização de uma chama oxidante de acetileno / óxido nitroso. As melhores condições de funcionamento, tais como altura do queimador, fluxo de gases e taxa de aspiração da amostra foram definidas, sendo seus valores ideais para cada comprimento de onda respectivamente: 246,400 nm (9 mm - 0,186 - 5 mL min-1), para 324,616 nm (8 mm - 0,170 - 5 mL min-1) e de 213,618 nm (4 mm - 0,450 - 5 mL min-1). Boa linearidade foinobtida para o intervalo de concentração 250 - 4000 mg L-1 P usando o modo de integração do sinal de absorbância CP ± 2 (5 pixels), utilizando-se os sais Na2HPO3.5H2O, NaH2PO4, NH4H2PO4 e H3PO4. Os resultados mostraram que era irrelevante a natureza dos compostos para obter um padrão de P. Quatro diferentes modos de integração de absorbância foram avaliados: CP ± 1 (3 pixels), CP ± 2 (5 pixels), CP ± 3 (7 pixels) e CP ± 4 (9 pixels). Foi observado que a sensibilidade (inclinação da curva e massa característica) melhoraram com o aumento do número de pixels. O método de determinação de P pelo HR-CS FAAS em insumos agroindustriais foi comparada com a titulação. A exatidão e precisão foram de acordo com 95% de confiança, o desvio padrão relativo (RSD) obtido foi de 2,0%. Boas recuperações, cerca de 98%, foi obtida a partir de testes de adição e recuperação.
Abstract: It was developed a method for spectrometry determination of phosphorus in agroindustrial products. The method is based on the determination by high-resolution continuum source flame atomic absorption spectrometry technique (HR-CS FAAS) using the atomic line 213,618 nm and bands of 246,400 nm and 324,616 nm. It was studied the best conditions for the analysis, for the absorption by bands of PO and the line of P atomic. To the first the best form of analysis would be using an oxidizing air/acetylene flame for analyte atomization and the last an oxidizing acetylene/nitrous oxide flame. The best operating conditions was defined as the burner high, the gas flow rate and aspiration rate of the sample. The values for these operations conditions are respectively: to 246,400 nm ( 9 mm - 0,186 - 5 mL min-1), to 324,616 nm ( 8 mm - 0,170 - 5 mL min-1) and to 213,618 nm ( 4 mm - 0,450 - 5 mL min-1). Good linearity was obtained for the concentration range 250 - 4000 mg L-1 P using the wavelength integrate absorbance in CP ± 2 (5 pixels), using the salts Na2HPO3.5H2O, NaH2PO4, NH4H2PO4 e H3PO4. The results showed that the was irrelevant to the nature of the compound to obtain a standard of P. Four different wavelength integrated absorbance were evaluated: CP ± 1 (3 pixels), CP ± 2 (5 pixels), CP ± 3 (7 pixels) and CP ± 4 (9 pixels). It was observed that the sensitivity (slope and characteristic mass) improved with increased number of pixels. The method of analysis of P by HR-CS FAAS in agroindustrial products was compared with the titration. The accuracy and precision was agreement at 95% confidence level, the relative standard deviation (RSD) obtaneid was 2,0%. Good recoveries, about 98%, was obtained using test of addition and recovery.
Mestre
41
Ferreira, Roberta Borges [UNESP]. "Estratégias analíticas para determinação de fósforo por espectrometria de absorção atômica com fonte contínua de alta resolução." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/97846.
Full textAbstract:
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Foi desenvolvido um método para a determinação espectrométrica de fósforo em insumos agroindustriais. O método está baseado na determinação por Espectrometria de Absorção atômica com Fonte Contínua de Alta Resolução (HR-CS AAS) utilizando a linha atômica 213,618 nm e bandas de 246,400 nm e 324,616 nm. Foram estudadas as melhores condições para a análise via absorção pelas bandas de PO e da linha de P atômica. Para a primeira, a melhor forma de análise foi utilizar a chama oxidante ar / acetileno, já para a última situação a atomização foi pela utilização de uma chama oxidante de acetileno / óxido nitroso. As melhores condições de funcionamento, tais como altura do queimador, fluxo de gases e taxa de aspiração da amostra foram definidas, sendo seus valores ideais para cada comprimento de onda respectivamente: 246,400 nm (9 mm – 0,186 – 5 mL min-1), para 324,616 nm (8 mm – 0,170 – 5 mL min-1) e de 213,618 nm (4 mm – 0,450 – 5 mL min-1). Boa linearidade foinobtida para o intervalo de concentração 250 – 4000 mg L-1 P usando o modo de integração do sinal de absorbância CP ± 2 (5 pixels), utilizando-se os sais Na2HPO3.5H2O, NaH2PO4, NH4H2PO4 e H3PO4. Os resultados mostraram que era irrelevante a natureza dos compostos para obter um padrão de P. Quatro diferentes modos de integração de absorbância foram avaliados: CP ± 1 (3 pixels), CP ± 2 (5 pixels), CP ± 3 (7 pixels) e CP ± 4 (9 pixels). Foi observado que a sensibilidade (inclinação da curva e massa característica) melhoraram com o aumento do número de pixels. O método de determinação de P pelo HR-CS FAAS em insumos agroindustriais foi comparada com a titulação. A exatidão e precisão foram de acordo com 95% de confiança, o desvio padrão relativo (RSD) obtido foi de 2,0%. Boas recuperações, cerca de 98%, foi obtida a partir de testes de adição e recuperação.
It was developed a method for spectrometry determination of phosphorus in agroindustrial products. The method is based on the determination by high-resolution continuum source flame atomic absorption spectrometry technique (HR-CS FAAS) using the atomic line 213,618 nm and bands of 246,400 nm and 324,616 nm. It was studied the best conditions for the analysis, for the absorption by bands of PO and the line of P atomic. To the first the best form of analysis would be using an oxidizing air/acetylene flame for analyte atomization and the last an oxidizing acetylene/nitrous oxide flame. The best operating conditions was defined as the burner high, the gas flow rate and aspiration rate of the sample. The values for these operations conditions are respectively: to 246,400 nm ( 9 mm – 0,186 – 5 mL min-1), to 324,616 nm ( 8 mm – 0,170 - 5 mL min-1) and to 213,618 nm ( 4 mm – 0,450 - 5 mL min-1). Good linearity was obtained for the concentration range 250 – 4000 mg L-1 P using the wavelength integrate absorbance in CP ± 2 (5 pixels), using the salts Na2HPO3.5H2O, NaH2PO4, NH4H2PO4 e H3PO4. The results showed that the was irrelevant to the nature of the compound to obtain a standard of P. Four different wavelength integrated absorbance were evaluated: CP ± 1 (3 pixels), CP ± 2 (5 pixels), CP ± 3 (7 pixels) and CP ± 4 (9 pixels). It was observed that the sensitivity (slope and characteristic mass) improved with increased number of pixels. The method of analysis of P by HR-CS FAAS in agroindustrial products was compared with the titration. The accuracy and precision was agreement at 95% confidence level, the relative standard deviation (RSD) obtaneid was 2,0%. Good recoveries, about 98%, was obtained using test of addition and recovery.
42
Enlow, Charles Alva. "The thirteen barcarolles for piano by Gabriel Fauré : an analytical and interpretive study /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004199.
Full text
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Fu, Hsueh-Hung. "Analytical and computational modeling of the mechanical response of polycrystalline and nanocrystalline metals /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3099911.
Full text
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Kelly, Annela Rämmer. "Weakly analytic vector-valued measures /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9821334.
Full text
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Di, Marzo Giuseppe. "Advanced Analytics per il Marketing: clustering dei clienti fidelizzati." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
Find full textAbstract:
Questo elaborato descrive un progetto di cluster analysis svolto in Iconsulting per un’azienda di fashion retail.
Lo scopo di questo progetto è clusterizzare i clienti fidelizzati dell’azienda di fashion retail e testare varie piattaforme che permettono analisi avanzate, in particolare il clustering.
Le clusterizzazioni sono state effettuate tramite il linguaggio R, sono stati sperimentati diversi algoritmi di clustering, tenendo in considerazione effcienza e qualità del risultato.
K-means è stato considerato il più adatto degli algoritmi sperimentati.
È stata svolta una piccola analisi sugli outliers, sempre utilizzando R, che ha portato a importanti riflessioni sul trattamento delle quantità monetarie.
È stata sviluppata ed implementata in R una metrica di qualità basata sul coeffciente di silhouette a complessità temporale lineare; tale metrica è stata utilizzata per scegliere, a partire da diverse clusterizzazioni effettuate con k-means e variando il numero di cluster, la clusterizzazione a qualità massima.
I clienti fidelizzati sono stati clusterizzati diverse volte considerando ogni volta diversi aspetti delle loro abitudini d’acquisto, data l’impossibilità di trattare il cliente al massimo livello di dettaglio.
Ogni clusterizzazione è stata realizzata applicando ripetutamente l’algoritmo k-means al dataset preparato variando il k da 2 a 10, scegliendo poi il risultato a qualità massima.
Le clusterizzazioni ottenute risultano soddisfacenti ed informative e verranno utilizzate per successive campagne di marketing e di CRM.
46
Santos, Marina. "ANALYTICAL POTENTIAL OF POLYMERIZED LIPOSOMES BOUND TO LANTHANIDE IONS FOR QUALITATIVE AND QUANTITATIVE ANALYSIS OF PROTEINS." Doctoral diss., University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2587.
Full textAbstract:
One of the intriguing features of biological systems is the prevalence of highly selective and often very strong interactions among different cellular components. Such interactions play a variety of organizational, mechanical, and physiological roles at the cellular and organism levels. Antigen-antibody complexes are representative examples of highly selective and potent interactions involving proteins. The marked specificity of protein-antibody complexes have led to a wide range of applications in cellular and molecular biology related research. They have become an integral research tool in the present genomic and proteomic era. Unfortunately, the production of selective tools based on antigen-antibody interactions requires cumbersome protocols. The long term goal of this project explores the possibility of manipulating liposomes to serve as the chemical receptors ("artificial antibodies") against selected proteins. Cellular lipids (e.g., lipid rafts) are known to facilitate highly selective binding of proteins on cell membranes. The binding of proteins to cell membranes can be envisaged to be modulated via interactions between polar (charged) and non-polar head groups of lipids and the complementary amino acid residues of proteins. Their interaction is facilitated by a combination of van der Waals, electrostatic, hydrogen bonding and hydrophobic forces. A further interesting aspect of the above interaction is the "fluidity" of the membrane resident lipids, which can migrate from other regions to further enhance the complementary interactions of proteins on the initially "docked" membrane surface. With these features in mind, the end goal of this project is expected to deliver lipid-based chemical receptors "synthetically" designed against proteins to function as "artificial antibodies". Protein sensing will be accomplished with lipid receptors assembled in templated polymerized liposomes. The research presented here specifically focus on the analytical aspects of protein sensing via polymerized liposome vesicles. Lanthanide ions (Eu(III) and Tb(III)) are incorporated into polymerized liposome with the expectation to "report" quantitative and qualitative information on the interacting protein. Our proposition is to extract quantitative and qualitative information from the luminescence intensity and the luminescence lifetime of the lanthanide ion, respectively. A thorough investigation is presented regarding the analytical potential of these two parameters for protein sensing. Two chemometic approaches - namely partial least squares (PLS-1) and artificial neural networks (ANN) - are compared towards quantitative and qualitative analysis of proteins in binary mixtures.Ph.D.
Department of Chemistry
Sciences
Chemistry: Ph.D.
47
Santos, Marina. "ANALYTICAL POTENTIAL OF POLYMERIZED LIPOSOMES BOUND TO LANTHANIDE IONS FOR QUALITATIVE AND QUANTITATIVE ANALYSIS OF PROTEINS." Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2588.
Full textAbstract:
One of the intriguing features of biological systems is the prevalence of highly selective and often very strong interactions among different cellular components. Such interactions play a variety of organizational, mechanical, and physiological roles at the cellular and organism levels. Antigen-antibody complexes are representative examples of highly selective and potent interactions involving proteins. The marked specificity of protein-antibody complexes have led to a wide range of applications in cellular and molecular biology related research. They have become an integral research tool in the present genomic and proteomic era. Unfortunately, the production of selective tools based on antigen-antibody interactions requires cumbersome protocols. The long term goal of this project explores the possibility of manipulating liposomes to serve as the chemical receptors ("artificial antibodies") against selected proteins. Cellular lipids (e.g., lipid rafts) are known to facilitate highly selective binding of proteins on cell membranes. The binding of proteins to cell membranes can be envisaged to be modulated via interactions between polar (charged) and non-polar head groups of lipids and the complementary amino acid residues of proteins. Their interaction is facilitated by a combination of van der Waals, electrostatic, hydrogen bonding and hydrophobic forces. A further interesting aspect of the above interaction is the "fluidity" of the membrane resident lipids, which can migrate from other regions to further enhance the complementary interactions of proteins on the initially "docked" membrane surface. With these features in mind, the end goal of this project is expected to deliver lipid-based chemical receptors "synthetically" designed against proteins to function as "artificial antibodies". Protein sensing will be accomplished with lipid receptors assembled in templated polymerized liposomes. The research presented here specifically focus on the analytical aspects of protein sensing via polymerized liposome vesicles. Lanthanide ions (Eu3+ and Tb3+) are incorporated into polymerized liposome with the expectation to "report" quantitative and qualitative information on the interacting protein. Our proposition is to extract quantitative and qualitative information from the luminescence intensity and the luminescence lifetime of the lanthanide ion, respectively. A thorough investigation is presented regarding the analytical potential of these two parameters for protein sensing. Two chemometic approaches - namely partial least squares (PLS-1) and artificial neural networks (ANN) - are compared towards quantitative and qualitative analysis of proteins in binary mixtures.Ph.D.
Department of Chemistry
Sciences
Chemistry: Ph.D.
48
Elias, Ricardo. "A VIRTUAL REALITY VISUALIZATION OFAN ANALYTICAL SOLUTION TOMOBILE ROBOT TRAJECTORY GENERATIONIN THE PRESENCE OF MOVING OBSTACLES." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2438.
Full textAbstract:
Virtual visualization of mobile robot analytical trajectories while avoiding moving obstacles is presented in this thesis as a very helpful technique to properly display and communicate simulation results. Analytical solutions to the path planning problem of mobile robots in the presence of obstacles and a dynamically changing environment have been presented in the current robotics and controls literature. These techniques have been demonstrated using two-dimensional graphical representation of simulation results. In this thesis, the analytical solution published by Dr. Zhihua Qu in December 2004 is used and simulated using a virtual visualization tool called VRML.M.S.E.E.
School of Electrical Engineering and Computer Science
Engineering and Computer Science
Electrical Engineering MSEE
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Chen, Yanwei. "Analytical and statistical modeling to evaluate effectiveness of stream restoration in reducing stream bank erosion." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2005. http://wwwlib.umi.com/cr/syr/main.
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Ip, Louisa Pui Sum. "An analytical and simulation study of wireless ad hoc networks with and without cooperation." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3404152.
Full textAbstract:
Thesis (Ph. D.)--University of California, San Diego, 2010.Title from first page of PDF file (viewed June 10, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (leaves 87-91).