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Dissertations / Theses on the topic 'Analytical Method Development and Validation'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Brown, Jared R. "Analytical Methods Development for High-Throughput Photochemisty With Led Arrays." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/32709.

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This thesis describes the design, construction, and evaluation of a series of LED array photolysis systems for high throughput photochemistry. Three generations of array systems of increasing sophistication are evaluated using calorimetric measurements and potassium tris(oxalato)ferrate(III) chemical actinometry. The results are analyzed using descriptive statistics and analysis of variance (ANOVA). The LEDs in the third generation array were shown to be statistically equivalent, with respect to light output, according to physical and chemical actinometry experiments. The third generation

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2

Malm, Mikaela. "Drug Analysis : Bioanalytical Method Development and Validation." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8547.

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This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. Developed bioanalytical methods are validated according to international guidelines. Eflornithine (DFMO) is a chiral drug, used for treating human African trypanosomiasis. A bioanalytical method for determination of DFMO enantiomers in plasma is presented. The enantiomers are detected by evaporative light-scatteri

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Lindholm, Johan. "Development and Validation of HPLC Methods for Analytical and Preparative Purposes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4442.

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Pingeon, Marine. "Development and validation of analytical methods for therapeutic drug monitoring." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4509.

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2017 - 2018<br>The U.S. Food and Drug Administration defines as Precision or Personalized Medicine (PM) an innovative therapeutic approach that tailors therapy and prevention on patients based on inter-individual variabilities in molecular or environmental features and in lifestyles. The major goals of PM are to maximize treatment efficacy and to reduce cost, toxicities and therapy failure rates by early identification of patients who might benefit or not of a specific treatment. In this scenario, therapeutic drug monitoring (TDM) is an important laboratory tool for PM because of the poss

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Holman, Miranda K., Dorcas Frempong, Stacy Brown, Steven Dinh, and Ashana Puri. "Development and Validation of a Liquid Chromatography-Mass Spectrometry Based Analytical Assay for Determination of Cromolyn Sodium in Skin Permeation Studies." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/45.

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Cromolyn sodium (CS) is a mast cell stabilizer which has been used to treat systemic mastocytosis, allergic- and exercise-induced asthma, and allergic reactions induced by atopic dermatitis. Presently, CS is administered orally and intranasally, and with a short half-life and poor absorption, 4 to 8 doses are required daily for treatment. Developing a transdermal product for CS would eliminate such drawbacks that lead to inconsistent patient dosing and provide sustained therapeutic effects when administered via skin. Our long-term goal is to determine the feasibility of delivering CS through s

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Jonsson, Ann-Sofie. "Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Cyclosporine A in Whole Blood." Thesis, Karlstad University, Division for Chemistry, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-5511.

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<p>Cyklosporin A (CsA) är en cyklisk polypeptid med molekylvikten är 1202.6 Da. Substansen har svampursprung (<em>Tolypocladium inflatum Gams)</em> och starka immunhämmande egenskaper. CsA används därför som immunsuppressivt läkemedel för att förhindra avstötning av transplanterade organ och benmärg, samt vid behandling av graft-versus-host-disease (transplantat-mot-värd-sjukdom). CsA har ett snävt terapeutiskt fönster, vilket betyder att skillnaden mellan effektivitet och toxicitet är liten. Biverkningarna av substansen är många och en del av dem allvarliga, såsom nedsatt njurfunktion och öka

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Amann, Laura. "Development and Validation of an Analytical Method for Phenolic Acid Extraction from Cereals and Quantification using HPLC-UV." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-77227.

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Cereals are rich in phenolic acids, a group of secondary plant metabolites that are associated with reduced risk of chronic diseases. The objective was to develop and internally validate a method for extraction and quantification of phenolic acids in cereals using HPLC-UV and to apply this method for quantification of the content of phenolic acids in several species of Swedish cereals. Different procedures for extraction of phenolic acids from cereal grains using acid or base hydrolysis with and without subsequent enzymatic treatment were tested. Both the extraction procedure and the chromatog

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8

Persson, Emelie. "Development and validation of a method for separation of pregabalin and gabapentin capsules using Near Infrared hyperspectral imaging." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-161108.

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Seizures containing large numbers of units of narcotics, goods dangerous to health and doping are often sent to the Swedish National Forensic Centre (NFC). Only a fraction of these capsules or tablets can be analyzed, therefore the samples need to represent the whole seizure. If the samples show content variations, Near Infrared (NIR) spectroscopy in combination with hyperspectral imaging has been shown to be a promising tool to gauge the homogeneity in the seizures based on chemical content. The objective of this thesis was to further develop and then validate a method for the separation of p

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9

Jackson, Remonica, Mariah Huskey, and Stacy Brown. "Development and validation of a liquid chromatography-tandem mass spectrometric method for quantification of nicotine in e-cigarette liquids." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/238.

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Introduction. Popularity of electronic cigarettes (e-cigarettes) has increased dramatically in recent years, especially among adolescents. The most recent data from the National Institute on Drug Abuse (NIDA) cites that >16% of 12th graders have tried e-cigarettes, and >30% of those individuals will start smoking within 6 months1. E-cigarettes are available in a variety of ‘strengths’ indicating the labeled nicotine concentration in the product. In this project, we sought to investigate the accuracy of nicotine labeling found in some commercially available e-liquids. As such, we developed and

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10

Arnell, Robert. "Development and Validation of Methods for Characterization of Multi-Component Systems in Preparative LC." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7422.

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MASTROIANNI, RITA. "Development and validation of analytical methods based on mass-spectrometry for the determination of bioactive-molecules." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115202.

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FRIGERIO, GIANFRANCO. "DEVELOPMENT, VALIDATION, AND APPLICATION OF ANALYTICAL ASSAYS FOR THE HUMAN BIOMONITORING OF VOLATILE AND PERSISTENT ORGANIC COMPOUNDS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/816457.

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Il monitoraggio biologico è un utile approccio per valutare l'esposizione umana a sostanze inquinanti. Lo scopo di questo progetto è stato quello di sviluppare nuovi metodi analitici per il biomonitoraggio dell'esposizione umana a inquinanti organici volatili e persistenti, oltre alla loro applicazione a determinati gruppi di soggetti e ad un confronto tra diversi approcci (approcci mirati e non-mirati). Un metodo in spettrometria di massa tandem accoppiato con la cromatografia liquida in fase inversa (HPLC-MS/MS) è stato sviluppato per l'analisi di un totale di 17 acidi mercapturici urinari,

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Rodriguez, Frausto Heriberto. "Development and analytical validation of a gas chromatography-mass spectrometry method for the assessment of gastrointestinal permeability and intestinal absorptive capacity in dogs." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3257.

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Rowhani, Touraj. "Development and validation of an analytical method for determination of polyhexamethylene biguanide level in the presence of quaternary ammonium compounds in recreational water." Click here for download, 2006. http://wwwlib.umi.com/cr/villanova/fullcit?p1432527.

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Löfgren, Mikael. "Mätning av viskositet på stärkelse." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104924.

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Stärkelse används vid papperstillverkning för att öka styrkeegenskaperna hos pappret. Denna stärkelse kan av olika anledningar brytas ned och bli sämre, då främst på grund av bakterier. Detta kan leda till försämrad papperskvalitet och i värsta fall kassationer av slutprodukten. För att undersöka om stärkelsen blivit angripen av bakterier kan man göra en bakterieodling. Nackdelen med detta är att det tar väldigt lång tid innan man ser något resultat. En annan effekt av bakterierna är att stärkelsens viskositet blir lägre, dvs. vätskan blir mindre trögflytande. Detta är en parameter som kan mät

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LA, MAIDA NUNZIA. "Development and validation of analytical methods with hyphenated chromatographic techniques for the determination of NPS and drugs of abuse in biological matrices." Doctoral thesis, Università Politecnica delle Marche, 2022. https://hdl.handle.net/11566/299808.

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Sin dal 1990 l'apparizione sul mercato di nuove sostanze psicoattive (NPS) è un fenomeno mondiale sempre crescente. Ogni anno vengono introdotte nuove sostanze nel mercato della droga come alternative legali alle sostanze controllate dalla legge. L’identificazione di queste nuove sostanze in matrici biologiche rappresenta una continua sfida per i laboratori di analisi. È estremamente importante sviluppare metodologie analitiche in grado di identificare sostanze sconosciute consentendone il monitoraggio e fornendo informazioni scientifiche riguardo la farmacocinetica, possibili range di tossici

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Xu, Gang. "PART I. COMPREHENSIVE STUDY OF HERBAL MEDICINE FORMULA SHUANG HUANG LIAN BY UNTARGETED PROFILING WITH UHPLC-QTOF-MS AND NETWORK PHARMACOLOGYPART II. DEVELOPMENT OF UHPLC-MS/MS-BASED ASSAY FOR CARDIOLIPIN, A BIOMARKER OF HUMAN DISEASES." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1560269742841914.

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Clarin, Leona. "Development and validation of an ultrafiltration-UHPLC-MS/MS method for the quantification of unbound Beta-Lactam antibiotics cefotaxime, piperacillin, cloxacillin and flucloxacillin in plasma." Thesis, KTH, Tillämpad fysikalisk kemi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-287570.

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Infections in critically ill patients are a problem for the healthcare system and at any one time, 70 % of all intensive care unit (ICU) patients are treated with antibiotics. Antibiotics bind toproteins in the blood, but only unbound drug can diffuse over capillary membranes and bindto the targeted receptor. Standard protein binding percentages for antibiotics have been developed from studies on healthy volunteers and dosing regimens for patients are adapted accordingly. The determination of the total concentration of antibiotics in patients’ bloodsamples is, based on the standard percentages

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Huang, Qianyang. "Development and Validation of UPLC/MS/MS Methods for Quantification of Gangliosides in the Clinical Study of Ganglioside GM3 Synthase Deficiency." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1472042152.

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Hui, Yu. "Development, validation and application of analytical methods to measure prognostic biomarkers in patients receiving on-pump coronary artery bypass grafting surgery." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44155.

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Temporary interception and then re-infusion of oxygenated blood into heart during on-pump Coronary Artery Bypass Grafting (CABG) surgery causes ischemia-reperfusion injury (IRI). Propofol is an intravenous anesthetic agent that maybe potentially cardioprotective against IRI. This thesis presents the development, validation and application of analytical methods for monitoring propofol and a series of prognostic biomarkers in hope of identifying contributory factors to IRI and propofol cardioprotection. I developed a Capillary Electrophoresis (CE) method to quantify propofol concentrations in bl

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Lindegårdh, Niklas. "Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids." Doctoral thesis, Uppsala University, Analytical Chemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3346.

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<p>This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper.</p><p>Methods for the determination of atovaquone (ATQ) in plasma, whole blood and capillary blood applied onto sampling paper were developed and validated. </p><p>Automated solid-phase extraction (SPE) and liquid chromatography (LC) with UV absorbance detection was used to quantify ATQ. Venous blood contained higher leve

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Sia, Xin Rong. "Development of a rapid and in-field phenotyping tool for screening protein quality in soybeans (Glycine max) using a miniature near infrared sensor." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574800276913103.

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Schaefer, Cédric. "A Process Analytical Technology (PAT) approach involving near infrared spectroscopy to control the manufacturing of an active pharmaceutical ingredient : development, validation and implementation." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4375.

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Les entreprises pharmaceutiques ont progressivement adopté le concept de Process Analytical Technology (PAT) afin de contrôler et d'assurer en temps réel la qualité des produits pharmaceutiques au cours de leur production. Le PAT et un composant central du concept plus général de Quality-by-Design (QbD) promu par les agence régulatrices et visant à construire la qualité des produits via une approche scientifique et la gestion des risques.Une méthode basée sur la spectroscopie proche infrarouge (PIR) a été développée comme un outil du PAT pour contrôler en ligne la cristallisation d'un principe

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Schaefer, Cédric. "A Process Analytical Technology (PAT) approach involving near infrared spectroscopy to control the manufacturing of an active pharmaceutical ingredient : development, validation and implementation." Electronic Thesis or Diss., Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4375.

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Les entreprises pharmaceutiques ont progressivement adopté le concept de Process Analytical Technology (PAT) afin de contrôler et d'assurer en temps réel la qualité des produits pharmaceutiques au cours de leur production. Le PAT et un composant central du concept plus général de Quality-by-Design (QbD) promu par les agence régulatrices et visant à construire la qualité des produits via une approche scientifique et la gestion des risques.Une méthode basée sur la spectroscopie proche infrarouge (PIR) a été développée comme un outil du PAT pour contrôler en ligne la cristallisation d'un principe

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Samuelsson, Jörgen. "Development of Methods for Phase System Characterization in Liquid Chromatography." Doctoral thesis, Uppsala universitet, Ytbioteknik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8597.

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The aim of this thesis is first and foremost to improve the fundamental knowledge of nonlinear and preparative separation theory by focusing on some of the remaining “white spots” on the theoretical chromatographic map. Secondly, the acquired knowledge is used to develop, validate and execute new methods for phase characterization in liquid chromatography. The methodology used in this thesis is a combination of experiments, fundamental nonlinear theory and systematic computer simulations. A fundamental knowledge of the molecular interactions between the compounds to be separated and the separa

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Wei, Ruhan. "Part I: The role of RNase L in lipid homeostasis and the development of atherosclerosisPart II: The role of RNase L in lipopolysaccharide-induced lung inflammationPart III: Development of LC-MS/MS assay for GSK3 inhibitors in plasma." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu157902853120912.

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Arvidsson, Björn. "Quantitative Bioanalysis : Liquid separations coupled to targeted mass spectrometric measurements of bioactive compounds." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8581.

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Performing quantitative analysis of targeted bioactive compounds in biological samples, such as blood plasma, cerebrospinal fluid or extracts from pig liver, put high demands on the ruggedness of the method acquiring the results. In addition to the complexity of the sample matrix, the bioactive compounds targeted for analysis usually have low levels of natural abundance, further increasing the demand on the analytical method sensitivity. Furthermore, quantitation of analytes at trace levels in the presence of large amounts of interfering species in biofluids must aim for repeatable precision,

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Junior, Gilberto Ferreira Linhares. "Desenvolvimento e validaÃÃo de metodologia cromatogrÃfica para determinaÃÃo de bisfenol A em simulantes de alimentos de ensaios de migraÃÃo." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9483.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Este trabalho teve como objetivo o desenvolvimento e metodologia cromatogrÃfica para a determinaÃÃo de bisfenol A em quatro diferentes simulantes de alimentos utilizando cromatografia lÃquida de alta eficiÃncia e detector de arranjo de diodo (PDA) para suporte em enasios de migraÃÃo. Os simulantes utilizados foram A (Ãgua purificada), B (soluÃÃo aquosade Ãcido acÃtico a 3%), C (soluÃÃo aquosa de etanol a 10%) e D (soluÃÃo aquosa de etanol a 95%). A avaliaÃÃo preliminar das condiÃÃes de anÃlise foi conduzida com a finalidade de esta

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Gorityala, Shashank. "TARGETED AND UNTARGETED OMICS FOR DISEASE BIOMARKERS USING LC-MS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1547093694357568.

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Swiha, Stéphanie. "Optimisation du suivi de l'exposition aux hydrocarbures aromatiques polycycliques pendant la grossesse avec le développement et la validation de méthodes analytiques et biologiques Analysis of polycyclic aromatic hydrocarbons in human biological samples Development of an analytical method for the simultaneous quantitation of 24 regulated Polycyclic Aromatic Hydrocarbons (PAHs) in maternal and umbilical cord sera Validation of the analytical procedure for the determination of 22 regulated polycyclic aromatic hydrocarbons in maternal and umbilical cord sera." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB020.

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Les Hydrocarbures Aromatiques Polycycliques (HAP) sont principalement émis par les activités humaines et représentent l'un des principaux groupes de polluants dans l'air, les sols, les eaux et les aliments. Par conséquent, ils font l'objet d'une surveillance atmosphérique, et alimentaire. Cette étude s'attache au cas particulier de la femme enceinte et son fœtus. En effet, l'exposition pendant la grossesse est à l'origine de malformations fœtales, de prématurité et de troubles pouvant survenir ensuite chez l'enfant mais aussi chez l'adulte. À ce jour, seuls quelques HAP réglementés par l'envir

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Linhares, Junior Gilberto Ferreira. "Desenvolvimento e validação de metodologia cromatográfica para determinação de bisfenol A em simulantes de alimentos de ensaios de migração." reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/17524.

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LINHARES JUNIOR, Gilberto Ferreira. Desenvolvimento e validação de metodologia cromatográfica para determinação de bisfenol A em simulantes de alimentos de ensaios de migração. 2012. 101 f. : Dissertação (mestrado) - Universidade Federal do Ceará, Centro de Ciências Agrárias, Departamento de Tecnologia de Alimentos, Fortaleza-CE, 2012<br>Submitted by Nádja Goes (nmoraissoares@gmail.com) on 2016-06-08T15:09:14Z No. of bitstreams: 1 2012_dis_gflinharesjunior.pdf: 1691103 bytes, checksum: 0abb8d914beb4b36dee06bc962679c7b (MD5)<br>Approved for entry into archive by Nádja Goes (nmoraissoares@gmail.

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Shabir, Ghulam. "Evaluation and application of best practice in analytical method validation." Thesis, University of Sunderland, 2008. http://sure.sunderland.ac.uk/3778/.

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The coherent body of research described in the existing published work is concerned with new assay method development and validation using novel systematic approaches for pharmaceutical and diagnostic compounds. The first stage of the research was to study how analytical method development and validation are typically carried out at present and to formulate this into a simple step-by-step approach. Such a template and protocol was not only used as the foundation of this research programme but could also serve as a simple systematic guide for other practitioners and those new to the field. Furt

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Schlipp, Katherine M. "Analytical method development a mathematical approach /." Electronic version (PDF), 2004. http://dl.uncw.edu/etd/2004/schlippk/katherinschlipp.pdf.

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Masterson, Rebecca A. (Rebecca Ann). "Development and validation of empirical and analytical reaction wheel disturbance models." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/80018.

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Sirhan, Muthana Mohammed. "Development of a new analytical method to diagnose tuberculosis." Thesis, Bangor University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664478.

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The main objective of the work was to develop a novel analytical tool, incorporating EVA-biosensor technology, for the diagnosis of TB, and this was achieved in three parts. The first target of the first part was the total synthesis of two novel diastereomers of α-methyl-trans-cyclopropane mycolic acids (I) and (11) present in. the cell wall of Mycobacterium avium complex and Mycobacterium Kansasii. The second target of the first part was the synthesis of four cord factors as derivatives of compounds (I) and (II), in order to understand their interaction with the immune system and for use in b

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Eklundh, Odler Tea. "Analytical Method Development of Fluorinated Silanes using Mass Spectrometry." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-71052.

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The aim of this study was to develop an analytical method for fluorinated silanes. Furthermore, as a secondary aim, to explore if there would be possible to detect 1H,1H,2H,2H-perfluorooctyl triethoxysilane (6:2 PTrEtSi) and 1H,1H,2H,2H-perfluorodecyl triethoxysilane (8:2 PTrEtSi) in two different matrices, sludge and cosmetic extract. The method development included experiments using LC-MS, LC-MS/MS, UPC2, GC-MS and APGC-MS/MS and was carried out using standards containing 6:2 PTrEtSi and 8:2 PTrEtSi. The analytical method that worked best for the compounds was GC-MS/MS and an analytical meth

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Svensson, Ulrika. "Blink behaviour based drowsiness detection : method development and validation /." [Linköping, Sweden] : Swedish National Road and Transport Research Institute, 2004. http://www.vti.se.

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Kannan, Srinivas Bharathwaj. "Development and validation of an analytical model for the notched pocket damper seal." [College Station, Tex. : Texas A&M University, 2003. http://hdl.handle.net/1969.1/117.

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Thesis (M.S.)--Texas A&M University, 2003.<br>"Major Subject: Mechanical Engineering" Title from author supplied metadata (record created on Jul. 18, 2005.) Vita. Abstract. Includes bibliographical references.

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Meneely, Julie Patricia. "Development and validation of rapid analytical techniques for the determination of trichothecine mycotoxins." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534609.

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Guedes, Jhonyson Arruda Carvalho. "Validation of analytical method employing quechers and gc-ms for multiresidue determination of pesticides in guava." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12267.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A goiaba Ã uma das frutas tropicais mais populares e de grande aceitaÃÃo no Brasil e no mundo. A fruta goiaba pode ser alvejada por diversas pragas, reduzindo consideravelmente o rendimento da produÃÃo ocasionando a escassez da fruta no mercado. Visando o aumento da produtividade e consequentemente atender a demanda da populaÃÃo sÃo empregadas elevadas quantidades de agrotÃxicos com o intuito de combater as possÃveis pragas que venham acarretar a deterioraÃÃo da fruta. Dessa maneira, o desenvolvimento de mÃtodos analÃticos para a

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Coffey, Chelsea M. "ANALYTICAL METHOD DEVELOPMENT FOR THE DETECTION AND ANALYSIS OF PROTEIN CARBONYLS." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3737.

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Oxidative stress can result in changes to many biomolecules and also affect their activities. We are interested in protein carbonylation, a type of unnatural oxidation which has been associated with numerous degenerative disease states and is also a consequence of the natural aging process. Protein carbonyls are stable species, but countless analytical barriers exist in terms of their identification. Thus, the main goal of this work was to develop and optimize analytical methods that could be used to help us better understand which, where, and how proteins are being carbonylated. Initial studi

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Keefer, Keaton Andrew. "DEVELOPMENT AND VALIDATION OF AN ANALYTICAL CHARGE-HOLD-VENT MODEL FOR CRYOGENIC TANK CHILLDOWN." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1364996750.

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Jones, Cameron Bennion. "Development and Validation of a Vibration-Based Sound Power Measurement Method." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/9260.

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The International Organization for Standardization (ISO) provides no vibration-based sound power measurement standard that provides Precision (Grade 1) results. Current standards that provide Precision (Grade 1) results require known acoustic environments or complex setups. This thesis details the Vibration Based Radiation Mode (VBRM) method as one approach that could potentially be used to develop a Precision (Grade 1) standard. The VBRM method uses measured surface velocities of a structure and combines them with the radiation resistance matrix to calculate sound power. In this thesis the VB

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Najafi, Asadolahi Azadeh. "CFD simulation of Taylor flow in microchannels : method development and validation." Thesis, The University of Sydney, 2012. http://hdl.handle.net/2123/17836.

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Mileo, Marianna Correia AragÃo. "Saxitoxins GTX 2.3, EC 1.2 2.3 DCGTX in public water supply: stability and validation of analytical method." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11899.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>The water quality of reservoirs for water supply has been compromised due to eutrophication. Eutrophication favors the proliferation of cyanobacteria, and therefore cyanotoxins that can be produced and released at any stage of cell growth of cyanobacteria. When these are in excess toxins in reservoirs and fountains, represent a hazard to public health and may cause poisoning in humans and animals. Due to several published reports that indicate fatal poisoning caused by cyanotoxins in Brazil and the world, the Brazilian health aut

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Finnon, Yvonne Susanne. "Development of an analytical method for the organic impurity profiling of amphetamine." Thesis, University of Strathclyde, 2005. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21604.

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Bian, Juan. "Liquid Chromatography and Mass Spectrometry Based Analytical Method Development Towards Fast and Sensitive Analysis." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1557242729134942.

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Levin, Anders, and Jörgen Johannesson. "Validation and verification of a third degree optimization method." Thesis, Växjö University, School of Mathematics and Systems Engineering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-25.

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<p>Denna kombinerade magisteruppsats i matematik och datalogi handlar om en metod för att hitta ett lokalt minimum för en unimodal funktion inom ett intervall genom användning av ett femtegradspolynom. Femtegradspolynomet skapas med hjälp av interpolation baserad på funktionsvärdena samt första och andra derivatans värden i intervallets ändpunkter. I rapporten härleds matematiskt att metoden konvergerar, följt av ett bevis för att metoden konvergerar med en konvergenshastighet av tre. Slutligen testas metoden mot två referensmetoder för att se användningsbarheten. För detta beskrivs vissa mjuk

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Baby, André Rolim. "Desenvolvimento e avaliação da estabilidade de formulações cosméticas anticelulíticas contendo o extrato comercial de Trichilia catiguá Adr. Juss (e) Ptychopetalum olacoides Bentham, padronizado em flavonóides totais." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-04102007-192348/.

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A hidrolipodistrofia ginóide, popularmente denominada de celulite, é caracterizada como um processo distrófico que produz alterações estruturais dos elementos presentes na pele, como: modificações no tecido conjuntivo, comprometimento da microcirculação periférica cutânea, hipertrofia e hiperplasia dos adipócitos e edema. Os flavonóides são utilizados como substâncias ativas em preparações anticelulíticas por reduzirem a permeabilidade capilar. Os objetivos estabelecidos para esta pesquisa foram: (1) desenvolver emulsões cosméticas com finalidades anticelulíticas; (2) validar metodologia analí

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Wilson, James Harris. "Development and validation of a laminate flooring system sound quality test method." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29660.

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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Cunefare, Kenneth A.; Committee Member: Qu, Jianmin; Committee Member: Ryherd, Erica. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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