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Relevant bibliographies by topics / Ancient rome

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Academic literature on the topic 'Ancient rome'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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Journal articles on the topic "Ancient rome"

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Frischer, Bernard. "Ancient Rome mapped." Antiquity 91, no. 360 (December 2017): 1659–62. http://dx.doi.org/10.15184/aqy.2017.192.

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When I first began my teaching career in 1976 at the University of California, Los Angeles, the subject of Roman topography was difficult to teach to English-speaking students. Most of the scholarship was written in Italian, and much of the rest was in French and German. Over the past 40 years the situation has changed significantly. We now have two useful introductory surveys in English: Coarelli'sRome and environs(2014) and Claridge'sRome: an Oxford archaeological guide(2010). We also have a host of monographic studies and, since 1988, innumerable articles and book reviews in theJournal of Roman Archaeology. Richardson's (1992)A new topographical dictionary of ancient Romeupdated the one venerable but antiquated English reference work that we had long had: Platner and Ashby's (1926)A topographical dictionary of ancient Rome. Meanwhile, at least for polyglot scholars, the situation became even more favourable with the appearance of Steinby's (1992–2001)Lexicon Topographicum Urbis Romae(LTUR), a collaborative work by a distinguished international team writing in Italian, French, German and English, with around 2300 individual entries on specific sites and monuments of the ancient city.

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Holleran, Claire. "Rome Awards: Shopping in ancient Rome." Papers of the British School at Rome 78 (November 2010): 311–12. http://dx.doi.org/10.1017/s006824620000101x.

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Cavanna, Andrea E. "Psychotherapy in ancient Rome." Cognitive Neuropsychiatry 25, no. 4 (June 22, 2020): 328–31. http://dx.doi.org/10.1080/13546805.2020.1784124.

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Corbeill, Anthony. ":Death in Ancient Rome." American Historical Review 113, no. 5 (December 2008): 1590–91. http://dx.doi.org/10.1086/ahr.113.5.1590.

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Kravchuk, Oleksiy, and Ivan Ostashchuk. "OATHS OF ANCIENT ROME." Visnyk of the Lviv University, no. 52 (2024): 138–46. http://dx.doi.org/10.30970/pps.2024.52.16.

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Newby, Zahra. "Rome Awards: Visualizing Greek athletics in ancient Rome." Papers of the British School at Rome 69 (November 2001): 407–8. http://dx.doi.org/10.1017/s0068246200001999.

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Tsapusova, Marina, and Anna Shmatova. "AGRICULTURAL DEVELOPMENT IN ANCIENT ROME." Agrarian History, no. 4 (2020): 10–16. http://dx.doi.org/10.52270/27132447_2020_4_10.

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Robinson, O. F., and Wilfred Nippel. "Public Order in Ancient Rome." American Journal of Legal History 41, no. 1 (January 1997): 160. http://dx.doi.org/10.2307/845495.

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Tara Mulder. "Adult Breastfeeding in Ancient Rome." Illinois Classical Studies 42, no. 1 (2017): 227. http://dx.doi.org/10.5406/illiclasstud.42.1.0227.

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Sprochi, Amanda K. "Sources: Artifacts from Ancient Rome." Reference & User Services Quarterly 54, no. 3 (2015): 58–59. http://dx.doi.org/10.5860/rusq.54n3.58b.

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Dissertations / Theses on the topic "Ancient rome"

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Toner, Jeremy Peter. "Leisure and ancient Rome." Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/272570.

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Bradley, M. "Concepts of colour in ancient Rome." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596850.

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This thesis is an attempt to understand how Romans of the early empire categorised, organised and applied colours. The study of colour has become familiar territory in recent anthropology, linguistics, art history and archaeology. Classicists, however, have traditionally subordinated the study of colour to form. By drawing together evidence and ideas floated by contemporary philosophers, elegists, epic writers, historians and satirists, this research reinstates colour as an essential informative unit for the classification and evaluation of the Roman world. It also demonstrates that the question of what colour is and how it functions - as well as how it could be abused and mislead the senses - were high on the Roman intellectual agenda. Chapter one examines a range of Roman responses to the rainbow, the locus classicus of colour discrimination and explores how Romans discussed and interpreted this difficult phenomenon. It then demonstrates that such discussion was deeply embedded in a Greek and Hellenistic philosophical tradition which was concerned with the relationship between perception, the physical world, and knowledge. It explores the impact of these debates on Roman discussions of color, and examines key passages on colour from Lucretius, Cicero, Pliny the Elder and Aulus Gellius. The aim of the chapter is to reach an understanding of the scope and nature of concepts of color in early imperial Rome, and the differences between Latin color and our notion of “colour”. Chapter two demonstrates that the Romans had a handful of colours which were primarily displayed and formulated on the body. This chapter studies Roman interpretations of natural skin, hair and eye colour and the strong ties that existed between these categories and behaviour, character and origin, as well as the interpretation of colour changes in the form of blushing and blanching. It then moves on to consider the manipulation of colour through cosmetics and costume dyes, and the ethical problems this generated. The chapter finishes with sea-purple dye (purpura) and argues that this artificial cosmetic colour was an ancient paradigm for the development of “abstract” colours. Chapter three studies the distribution and interpretation of colour in the Roman urban landscape. Discourse on the landscape and architecture of imperial Rome was deeply concerned with the accurate evaluation of the objects one perceived; uiridis and caeruleus, for example, were primarily properties of plants and deep water (rather than abstract colours). The cultural effort that made these colour-object connections, however, is best demonstrated by a consideration of how Romans made sense of a wide range of colourful marbles from all over the empire, classified by origin, rather than (as we normally do) by colour. I finish by comparing responses to two important phases of Roman urban development, that of Augustan Rome and that of Neronian Rome (in particular the Domus Aurea) and explore, from the point of view of colour, some of the philosophical problems that accompanied advanced artistic and architectural techniques and resources.

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McKinnon, Emily Grace. "Ovid's Metamorphoses: Myth and Religion in Ancient Rome." Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1483.

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The following with analyze Ovid’s Metamorphoses, a collection of myths, as it relates to mythology in ancient Rome. Through the centuries, the religious beliefs of the Romans have been distorted. By using the Metamorphoses, the intersection between religion and myth was explored to determine how mythology related to religion. To answer this question, I will look at Rome’s religious practices and traditions, how they differed from other religions and the role religion played in Roman culture, as well as the role society played in influencing Ovid’s narrative. During this exploration, it was revealed that there was no single truth in Roman religion, as citizens were able to believe and practice a number of traditions, even those that contradicted one another. Furthermore, the Metamorphoses illustrated three integral aspects of Roman religious beliefs: that the gods existed, required devotion, and actively intervened in mortal affairs.

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Mackenzie, Vanessa E. "Egypt, Rome and Aegyptophilia : rethinking Egypt's relationship with ancient Rome through material culture." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/50218/.

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This thesis is concerned to demonstrate that Egypt had an important part to play in the formation of the Roman empire. There is a tendency for Classical scholarship to discuss Rome’s relationship with Egypt in terms which fall very far short of the way in which Rome’s encounters with Greek culture are treated. Within scholarship today, any perceived problems with Egypt are still often overstated, while any respect which the Romans may have held for Egyptian culture is dismissed, underplayed or only grudgingly accepted. I intend to re-appraise certain aspects of Egyptian/Egyptianising material culture in order to demonstrate that while some areas of the Roman literary corpus are scattered with apparently derogatory remarks about Egypt, the material evidence tells a quite different story. The aim of this thesis is to examine Egyptian/Egyptianising material culture in order to put the evidence of written texts into a fuller cultural context and perspective. I shall take a chronological approach and intend to focus primarily on artefacts found in the public sphere. The exception will be Chapter Four in which I shall discuss notions about Egypt in the private sphere. The final Chapter will conclude with Hadrian’s era in which the Villa at Tivoli may be seen as an expression of the merging of aspects of both public and private. Octavian’s so-called ‘propaganda’ campaign is central to the question of how scholarship deals with encounters between Egypt and Rome. After Egypt’s incorporation into the new empire of Rome, it was not in Octavian’s interests to continue a hostile disparagement of the country, given his status as pharaoh. I will argue that Octavian set in motion a rehabilitation of the country’s reputation by a policy of appeasement towards Egypt and by incorporating aspects of Egypt’s culture into Rome. It is my contention that Egypt had a greater role to play in the ideology of Rome’s empire, particularly through its first Emperor, than modern scholarship allows. I conclude that the ‘question of Egypt’ while complex, fluid and often contradictory, nevertheless was very much less negative than modern scholarship portrays.

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Miano, Daniele. "The cult of Virtues in Archaic and Mid-Republican Rome." Doctoral thesis, Scuola Normale Superiore, 2013. http://hdl.handle.net/11384/85657.

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In my thesis I study the origin and historical development at Rome of the cults of Virtues, namely divinities such as Fortuna, Ops, Salus, Victoria, Concordia, etc. Because of the close connection between these cults and the related concepts, I show that the study of these cults is an extremely important tool for investigating and understanding the process of identity-construction in Rome. An important part of my thesis is the study of modern scholarship. I carefully reviewed all the relevant scholarship starting from the 19th century, showing how the way the cults of virtues were explained and represented was heavily influenced by great Enlightenment myths and, in particular, by an evolutionist view of ancient religion. Even when evolutionism was seriously questioned by anthropologists, an evolutionist framework continued to be used for decades by specialists of Roman religion. If we look at Greek and Latin texts, we find out that the cult of virtues was explained as a purely religious phenomenon, whereas personifications existed as a rhetorical and literary technique, which consisted in creating fictional characters to move the audience of a performance. I argue that, without a specific reference to a cult, most literary evidence is useless to draw any reliable information about the cults of Virtues. In the analysis of ancient evidence I focus on three periods, choosing four case studies. The first is the archaic period (6th century BC): I demonstrate that Fortuna and Ops were not agrarian divinities and that their cult played an important role in establishing the political identity of the community. The second is 350–260 BC: I show that the introduction of the cults of Salus and Victoria was part of the process by which the emergent patrician-plebeian nobility attempted to legitimise its own rule. This pattern continues in the final period covered by this research, that of the Punic Wars, in which the cults of Salus and Victoria continue their development. The main conclusions of my thesis are as follows: 1) the cults of Virtues are a characteristic of Roman religion since the beginning of the historical evidence. Therefore, they cannot be used to formulate any evolutionistic or Hellenocentric argument on the history of Roman religion; 2) the (mostly epigraphic) Italian evidence shows that the cults were spread over a huge area already from the Mid-Republican period, both under Roman influence and independently. This suggests that processes of identity-construction built around the cults of Virtues occurred in other Italian cities and communities; 3) from 4th century BC Roman politicians founding temples dedicated to Virtues tried to establish a personal connection with that virtue. These connections, and the ways they are contested by others, are usually implicit rather than explicit. I believe that this depends on the competitiveness of Roman politics; 3) the foundation of the temples of Salus and Victoria do not favour the creation of exemplary stories centred around the founders, and this happens only for characters related to the far past, e.g. Servius Tullius and Fortuna.

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Sarefield, Daniel Christopher. "Burning knowledge : studies of bookburning in ancient Rome /." Download pdf, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092663236.

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Rutgers, Leonard Victor. "The Jews in late ancient Rome : evidence of cultural interaction in the Roman diaspora /." Leiden ; New York ; Köln : E.J. Brill, 1995. http://catalogue.bnf.fr/ark:/12148/cb35749789s.

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Oxley, Eden Grace. "DAUGHTERS OF ROME." Ohio University Honors Tutorial College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1307996002.

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Mohr, Kyle A. "The Mechanics of Imperialism in the Ancient World." Miami University Honors Theses / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1210189238.

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Brousseau, Eric. "«Politics and policy: Rome and Liguria 200-172 B.C." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95100.

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Stephen Dyson's The Creation of the Roman Frontier employs various anthropological models to explain the development of Rome's republican frontiers. His treatment of the Ligurian frontier in the second century BC posits a Ligurian policy' crafted largely by the Senate and Roman frontier tacticians' (i.e. consuls). Dyson consciously avoids incorporating the pressures of domestic politics and the dynamics of aristocratic competition. But his insistence that these factors obscure policy continuities is incorrect. Politics determined policy. This thesis deals with the Ligurian frontier from 200 to 172 BC, years in which Roman involvement in the region was most intense. It shows that individual magistrates controlled policy to a much greater extent than Dyson and other scholars have allowed. The interplay between the competing forces of aristocratic competition and Senatorial consensus best explains the continuities and shifts in regional policy.
The Creation of the Roman Frontier, l'uvre de Stephen Dyson, utilise plusieurs modèles anthropologiques pour illuminer le développement de la frontière républicaine. Son traitement de la frontière Ligurienne durant la deuxième siècle avant J.-C. postule une politique' envers les Liguriennes déterminer par le Sénat et les tacticiens de la frontière romain' (les consuls). Dyson fais exprès de ne pas tenir compte des forces de la politique domestique et la compétition aristocratique. Mais son insistance que ces forces cachent les continuités de la politique Ligurienne est incorrecte. Ce thèse évalue les développements dans la Ligurie entre les années 200 et 172 avant J.-C.les trentes ans pendant lesquelles les romains faisaient de la guerre à presque chaque année en Ligurie. La thèse montre que les individus influençaient la politique plus souvent et plus fortement que Dyson et autres historien(ne)s concèdent. Les continuités et changement dans la politique régionale sont mieux expliqués selon un cadre qui prend compte de la tension entre la compétition aristocratique et le consensus Sénatorial.

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Books on the topic "Ancient rome"

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Simon, James. Ancient Rome. New York: Knopf, 1990.

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Benoit, Peter. Ancient Rome. New York: Children's Press, 2012.

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Mack, Lorrie. Ancient Rome. New York, N.Y: DK, 2009.

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Macdonald, Fiona. Ancient Rome. Thaxden, Essex: Miles Kelly, 2014.

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Malam, John. Ancient Rome. Oxford: Raintree, 2008.

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Simon, Adams. Ancient Rome. London: Kingfisher, 2007.

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P, Saller Richard, ed. Ancient Rome. Mankato, Minn: Capstone Press, 2004.

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Philip, Steele. Ancient Rome. San Diego, CA: Silver Dolphin Books, 2001.

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Sheehan, Sean. Ancient Rome. Austin, Tex: Raintree-Steck Vaughn, 2000.

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Malam, John. Ancient Rome. Chicago, Ill: Raintree, 2008.

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Book chapters on the topic "Ancient rome"

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Rossi, Corinna. "Ancient Rome." In Egypt, Greece, and Rome, 87–115. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003255314-5.

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Gates, Charles, and Andrew Goldman. "Rome." In Ancient Cities, 378–97. 3rd ed. London: Routledge, 2024. http://dx.doi.org/10.4324/9780429278815-25.

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Rossi, Corinna. "Ancient Egypt." In Egypt, Greece, and Rome, 27–53. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003255314-3.

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Rossi, Corinna. "Ancient Greece." In Egypt, Greece, and Rome, 54–86. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003255314-4.

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Kumar, Rakesh. "Ancient Rome I." In Social Formations in the Medieval World, 1–50. London: Routledge India, 2024. http://dx.doi.org/10.4324/9781003478331-1.

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Kumar, Rakesh. "Ancient Rome II." In Social Formations in the Medieval World, 51–91. London: Routledge India, 2024. http://dx.doi.org/10.4324/9781003478331-2.

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Fuhrer, Therese. "Philosophy in Rome." In Ancient Philosophy, 545–76. First [edition]. | New York : Routledge, 2017.: Routledge, 2017. http://dx.doi.org/10.4324/9781315179339-15.

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Gates, Charles, and Andrew Goldman. "Rome after Augustus." In Ancient Cities, 451–81. 3rd ed. London: Routledge, 2024. http://dx.doi.org/10.4324/9780429278815-29.

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Dillon, Matthew, and Lynda Garland. "Early Republican Rome." In The Ancient Romans, 1–39. First edition. | New York : Routledge Taylor & Francis Ltd, 2021.: Routledge, 2021. http://dx.doi.org/10.4324/9781315678498-1.

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Wróblewski, Bartłomiej. "Ancient Greece and Rome." In State Liability and the Law, 13–20. London: Routledge, 2023. http://dx.doi.org/10.4324/9781003327103-3.

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Conference papers on the topic "Ancient rome"

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Halapsis, Alex. "SACRED POWER IN ANCIENT ROME." In TENDENZE ATTUALI DELLA MODERNA RICERCA SCIENTIFICA. European Scientific Platform, 2020. http://dx.doi.org/10.36074/05.06.2020.v4.22.

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Para, Iulia. "FEMININE SOCIAL STATUS IN ANCIENT ROME." In 6th SWS International Scientific Conference on Social Sciences ISCSS 2019. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sws.iscss.2019.5/s18.036.

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Ukhanova, Elena. "New data on the typology of ancient Slavonic mineas of the X – XIth centuries." In Tenth Rome Cyril-Methodian Readings. Indrik, 2020. http://dx.doi.org/10.31168/91674-576-4.34.

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The report is devoted to the structure and composition features of the of the ancient Slavic worship Minea in the light of the newly obtained data on the decoding of the Khludov glagolitic palimpsest of XI century (SHM, Khlud. 117) – the oldest Minea of the 11th century.

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Para, Iulia. "WOMEN, POLITICS AND IMMORALITY IN ANCIENT ROME." In 6th SWS International Scientific Conference on Social Sciences ISCSS 2019. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sws.iscss.2019.5/s18.039.

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"Female Statues in Ancient Greece and Rome." In 2017 International Conference on Financial Management, Education and Social Science. Francis Academic Press, 2017. http://dx.doi.org/10.25236/fmess.2017.30.

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Donina, Ludmila. "Correlation of semantic difference and grammatical variation in medieval text." In Tenth Rome Cyril-Methodian Readings. Indrik, 2020. http://dx.doi.org/10.31168/91674-576-4.07.

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In this article factual information by XVth century ancient writing «Hellenic and Roman Chronicle» is analysed and presented. The focus of the paper is on the Medieval theory of «words» and formationing of the paradigm of nouns.

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Trofimov, Artem. "Multilingualism in the heroic poem by Feofan Prokopovich “Epinicion”." In Tenth Rome Cyril-Methodian Readings. Indrik, 2020. http://dx.doi.org/10.31168/91674-576-4.32.

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The paper focuses on three versions of Feofan Prokopo-vich’s heroic poem “Epinikion” (in Slavonic, Polish and Latin). These different versions are analyzed in their correlation with Russian and European linguistic and cultural context. Differences in the functioning of ancient and chistian cultural elements of the three texts have been revealed in the research.

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Bryzgalov, M. A. "POZZOLANS OF ANCIENT ROME AND MODERN CONCRETE MIXES." In НАУКА, ИННОВАЦИИ И ТЕХНОЛОГИИ: ОТ ИДЕЙ К ВНЕДРЕНИЮ. Комсомольск-на-Амуре: Комсомольский-на-Амуре государственный университет, 2022. http://dx.doi.org/10.17084/978-5-7765-1502-6-2022-289.

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Sovrlić, Milica. "PROFESSION AND SERVICES OF ARCHITECTS IN ANCIENT ROME." In International scientific conference challenges and open issues of service law. Vol. 2. University of Kragujevac, Faculty of law, 2024. http://dx.doi.org/10.46793/xxmajsko2.215s.

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In Rome, constantly growing and prosperous, there was many opportunities for the development of architecture. The skill of construction was first demonstrated in public construction, where the generosity of the emperors allowed the architect to create amazing buildings in terms of utility, beauty, and monumentality, but also in the private sector where the architects deftly realised all the ideas of the owners. The paper examines the profession of architect as well as the services provided by architects

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Rozhdestvenskaya, Milena. "On the functionality of apocryphal stories in medieval Russian bookishness." In Tenth Rome Cyril-Methodian Readings. Indrik, 2020. http://dx.doi.org/10.31168/91674-576-4.27.

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The functions of the biblical Slavic-Russian apocrypha in manuscript collections depend on their perception by the ancient Russian scribes and the literary context of the manuscript. Cognitive, interpretative, magical, historical functions are associated with different genre forms, both book and folk. Particularly considered is the «apocryphal riddle» of two brothers from the manuscript of the XVIth century Stockholm Royal Library and manuscripts of the XVIIIth century collections of the Library of the Russian Academy of Sciences (St. Petersburg).

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Reports on the topic "Ancient rome"

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Strachan, Denis M., and Eric M. Pierce. Ancient Glass: A Literature Search and its Role in Waste Management. Office of Scientific and Technical Information (OSTI), July 2010. http://dx.doi.org/10.2172/1009767.

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Buchan, K. L., and R. E. Ernst. Paleoproterozoic dyke swarms and large igneous provinces of northern Canada and their use in understanding extension, rifting, and paleocontinental reconstructions. Natural Resources Canada/CMSS/Information Management, 2024. http://dx.doi.org/10.4095/332506.

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Giant mafic dyke swarms and related large igneous provinces play an important role in the understanding of the tectonic evolution of ancient continents and supercontinents. The information available for well dated Paleoproterozoic dyke swarms and large igneous provinces in northern Canada is summarized in this synthesis, with an emphasis on their age, geographic distribution, paleomagnetism, and potential linkages to coeval magmatic events. Their tectonic settings, with a focus on links to rifting and continental breakup, are also discussed. Finally, the use of giant dyke swarms and large igneous provinces for testing paleocontinental reconstructions is considered, based mainly on paleomagnetism or on matching coeval magmatic events or sequences of magmatic events (magmatic barcoding) between cratons.

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Hulen, J. B., J. W. Collister, and D. K. Curtiss. The role of active and ancient geothermal processes in the generation, migration, and entrapment of oil in the basin and Range Province, western USA. Final technical report. Office of Scientific and Technical Information (OSTI), June 1997. http://dx.doi.org/10.2172/534485.

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Hayward, N., and S. Paradis. Geophysical reassessment of the role of ancient lineaments on the development of the western margin of Laurentia and its sediment-hosted Zn-Pb deposits, Yukon and Northwest Territories. Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/330038.

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The role of crustal lineaments in the development of the western margin of Laurentia, Selwyn basin and associated sediment-hosted Zn-Pb deposits (clastic-dominated, Mississippi-Valley-type) in Yukon and NWT, are reassessed through a new 3-D inversion strategy applied to new compilations of gravity and magnetic data. Regionally continuous, broadly NE-trending crustal lineaments including the Liard line, Fort Norman structure, and Leith Ridge fault, were interpreted as having had long-standing influence on craton, margin, and sedimentary basin development. However, multiple tectonic overprints including terrane accretion, thrust faulting, and plutonism obscure the region's history. The Liard line, related to a transfer fault that bounds the Macdonald Platform promontory, is refined from the integration of the new geophysical models with published geological data. The geophysical models support the continuity of the Fort Norman structure below the Selwyn basin, but the presence of Leith Ridge fault is not supported in this area. The ENE-trending Mackenzie River lineament, traced from the Misty Creek Embayment to Great Bear Lake, is interpreted to mark the southern edge of a cratonic promontory. The North American craton is bounded by a NW-trending lineament interpreted as a crustal manifestation of lithospheric thinning of the Laurentian margin, as echoed by a change in the depth of the lithosphere-asthenosphere boundary. The structure is straddled by Mississippi Valley-type Zn-Pb occurrences, following their palinspastic restoration, and also defines the eastern limit of mid-Late Cretaceous granitic intrusions. Another NW-trending lineament, interpreted to be associated with a shallowing of lower crustal rocks, is coincident with clastic-dominated Zn-Pb occurrences.

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Hulen, J. B. Assessing the role of ancient and active geothermal systems in oil-reservoir evolution in the eastern Basin and Range province, western USA. Annual progress report, June 1, 1992--May 31, 1993. Office of Scientific and Technical Information (OSTI), July 1993. http://dx.doi.org/10.2172/10169872.

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Chamovitz, Daniel A., and Albrecht G. Von Arnim. eIF3 Complexes and the eIF3e Subunit in Arabidopsis Development and Translation Initiation. United States Department of Agriculture, September 2009. http://dx.doi.org/10.32747/2009.7696545.bard.

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Abstract:

The original working hypothesis of our proposal was that The “e” subunit of eIF3 has multiple functions from both within the nucleus and in the cytoplasm. Within this model, we further hypothesized that the “e” subunit of eIF3 functions in translation as a repressor. We proposed to test these hypotheses along the following specific aims: 1) Determine the subcellular localization of the interaction between eIF3e and other eIF3 subunits, or the COP9 signalosome. 2) Elucidate the biological significance of the varied subcellular localizations of eIF3e through generating Arabidopsis eIF3e alleles with altered subcellular localization. 3.) Purify different eIF3e complexes by tandem affinity purification (TAP). 4) Study the role of eIF3e in translational repression using both in vitro and in planta assays. eIF3 is an evolutionarily ancient and essential component of the translational apparatus in both the plant and animal kingdoms. eIF3 is the largest, and in some ways the most mysterious, of the translation factors. It is a multi-subunit protein complex that has a structural/scaffolding role in translation initiation. However, despite years of study, only recently have differential roles for eIF3 in the developmental regulation of translation been experimentally grounded. Furthermore, the roles of individual eIF3 subunits are not clear, and indeed some, such as the “e” subunit may have roles independent of translation initiation. The original three goals of the proposal were technically hampered by a finding that became evident during the course of the research – Any attempt to make transgenic plants that expressed eIF3e wt or eIF3e variants resulted in seedling lethality or seed inviability. That is, it was impossible to regenerate any transgenic plants that expressed eIF3e. We did manage to generate plants that expressed an inducible form of eIF3e. This also eventually led to lethality, but was very useful in elucidating the 4th goal of the research (Yahalom et al., 2008), where we showed, for the first time in any organism, that eIF3e has a repressory role in translation. In attempt to solve the expression problems, we also tried expression from the native promoter, and as such analyzed this promoter in transgenic plants (Epel, 2008). As such, several additional avenues were pursued. 1) We investigated protein-protein interactions of eIF3e (Paz-Aviram et al., 2008). 2) The results from goal #4 led to a novel hypothesis that the interaction of eIF3e and the CSN meets at the control of protein degradation of nascent proteins. In other words, that the block in translation seen in csn and eIF3e-overexpressing plants (Yahalom et al., 2008) leads to proteasome stress. Indeed we showed that both over expression of eIF3e and the csn mutants lead to the unfolded protein response. 3) We further investigated the role of an additional eIF3 subunit, eIF3h, in transalational regulation in the apical meristem (Zhou et al., 2009). Epel, A. (2008). Characterization of eIF3e in the model plant Arabidopsis thaliana. In Plant Sciences (Tel Aviv, Tel Aviv University). Paz-Aviram, T., Yahalom, A., and Chamovitz, D.A. (2008). Arabidopsis eIF3e interacts with subunits of the ribosome, Cop9 signalosome and proteasome. Plant Signaling and Behaviour 3, 409-411. Yahalom, A., Kim, T.H., Roy, B., Singer, R., von Arnim, A.G., and Chamovitz, D.A. (2008). Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translation. Plant J 53, 300-311. Zhou, F., Dunlap, J.R., and von Arnim, A.G. The translation initiation factor subunit eIF3h is .1 involved in Arabidopsis shoot apical meristem maintenance and auxin response. (submitted to Development).

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