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Journal articles on the topic '% and 2% ketoconazole'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

Scheinfeld, Noah S. "Xolegel (ketoconazole, 2%)." SKINmed 5, no. 5 (2006): 241. http://dx.doi.org/10.1111/j.1540-9740.2006.05928.x.

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Hameed, Sadia, Mohammad Majid Paracha, Farah Sagheer, Abdul Qayum Khan, and Sahibzada Mahmood Noor. "COMPARATIVE STUDY OF EFFICACY OF COMBINED TREATMENT WITH KETOCONAZOLE 2% CREAM AND ADAPALENE 0.1% GEL VS. KETOCONAZOLE 2% CREAM MONOTHERAPY IN PITYRIASIS VERSICOLOR." American Journal of Health, Medicine and Nursing Practice 7, no. 6 (2022): 33–40. http://dx.doi.org/10.47672/ajhmn.1029.

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Background: Pityriasis Versicolor (PV) is an infection of the superficial layers of skin caused by Malassezia yeasts. It is a non-contagious disease characterized by hypo and hyperpigmented macules on the body. Up to 40% of people face itching, decreased quality of life, social stigmatization, and embarrassment due to the lesions. Adapalene with Ketoconazole provides an efficient option for PV patients due to better toxicity profile and rapid action on the lesions. Objective: Comparison of efficacy of combined therapy with Ketoconazole 2% cream and adapalene 1% gel against Ketoconazole 2

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Kajal, Kosankar* Kamlesh Deore Sakshi Chavan Vaishnavi More Simran Chaudhari Komal Gawali. "Evaluation Of 1% And 2% Ketoconazole Shampoo." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 466–78. https://doi.org/10.5281/zenodo.15334729.

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Ketoconazole shampoo, an effective antifungal treatment, is widely used to combat dandruff, seborrheic dermatitis, and various other fungal infections. The active ingredient, ketoconazole, halts the growth of Malassezia, a common fungus associated with these scalp issues. Available in two strengths, 1% and 2%, the shampoo can be purchased over-the-counter in its 1% form, while the 2% formulation usually requires a prescription. These varying strengths cater to different levels of severity, with the 1% option being particularly popular for mild to moderate cases due to its accessibility and min

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HARMANYERİ, Yavuz, Coşkun ACAY, and Keramettin DOĞRUÖZ. "Seboreik Dermatit Tedavisinde, Topikal Ketokonazol Kullanımı." European Journal of Therapeutics 1, no. 1 (1990): 94–97. http://dx.doi.org/10.58600/eurjther.19900101-504.

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in our study, twenty patients (7 females and 13 males) with seborrhoeic dermatitis of the scalp were treated, in three randomized groups, tor o maximum eight weeks, with 1 % hydrocortisone, 2 & ketoconazole or 2 % ketoconazole + 1 % hydrocortisone. Patients who treated theese drugs, were followed tor three months. At the and of this study, either 2 % ketoconazole or 2 % ketoconazole + 1 % hydrocortisone were significantly better than 1 % hydrocortisone.

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Khozeimeh, Faezeh, Omid Savabi, Mohammad Ali Shahtalebi, and Mojtaba Noori. "Comparative Evaluation of Ketoconazole Tablet and Topical Ketoconazole 2% in Orabase in Treatment of Candida-Infected Denture Stomatitis." Journal of Contemporary Dental Practice 11, no. 2 (2010): 17–24. http://dx.doi.org/10.5005/jcdp-11-2-17.

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Abstract Aim Denture stomatitis is a common and recurring problem of denture wearers. Ketoconazole tablet is one of the antimycotic drugs that often has been used to treat this condition, but systemic use of this drug has some adverse effects that frequently lead to unfavorable compliance and treatment failure. This study was designed to compare the efficacy of topical ketoconazole 2% in orabase and ketoconazole tablet. Methods and Materials Thirty patients with denture stomatitis (positive culture) were divided into two groups. The first group received ketoconazole tablet (orally used 200 mg

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Parwarish and Rabia Ghafoor. "Comparative Study of Efficacy of Combined Treatment with Ketoconazole 2% Cream and Adapalene 0.1% Gel Versus Ketoconazole 2% Cream Monotherapy in Pityriasis Versicolor." Indus Journal of Bioscience Research 3, no. 5 (2025): 934–37. https://doi.org/10.70749/ijbr.v3i5.1702.

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Background and Aim: Pityriasis versicolor is a frequent cutaneous superficial mycotic infection of Malassezia species manifesting as hypopigmented or hyperpigmented scaly macules. Although topical antifungals such as ketoconazole are often employed, relapse and partial resolution of skin color changes are common. Recent observations suggest that the concurrent use of antifungals with agents such as adapalene (a topical retinoid) might have the potential to improve the treatment effectiveness by stimulating epidermal turnover and antifungal penetration. The present study aimed to compare the ke

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Kaeser, Benoite, Hagen Zandt, Fabrice Bour, Elke Zwanziger, Christophe Schmitt, and Xiaoping Zhang. "Drug-Drug Interaction Study of Ketoconazole and Ritonavir-Boosted Saquinavir." Antimicrobial Agents and Chemotherapy 53, no. 2 (2008): 609–14. http://dx.doi.org/10.1128/aac.00769-08.

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ABSTRACT Saquinavir, a potent human immunodeficiency virus protease inhibitor, is extensively metabolized by CYP3A4. Saquinavir is coadministered with ritonavir, a strong CYP3A4 inhibitor, to boost its exposure. Ketoconazole is a potent CYP3A inhibitor. The objectives of this study were to investigate the effect of ketoconazole on the pharmacokinetics of saquinavir/ritonavir and vice versa using the approved dosage regimens of saquinavir/ritonavir at 1,000/100 mg twice daily and ketoconazole at 200 mg once daily. This was an open-label, randomized two-arm, one-sequence, two-period crossover st

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Cam, Van Tran, Thuong Nguyen Van, Khang Tran Hau, et al. "Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor." Open Access Macedonian Journal of Medical Sciences 7, no. 2 (2019): 272–74. http://dx.doi.org/10.3889/oamjms.2019.092.

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AIM: Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor. MATERIAL AND METHODS: A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 weeks (Category I), Itraconazole 200 mg daily for one week (category II); Ketoconazole 2% foam daily for 2 weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy. RESUL

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9

Trang, Lê Thị Minh, Vũ Huy Lượng та Đỗ Thị Thu Hiền. "HIỆU QUẢ ĐIỀU TRỊ BỆNH VIÊM DA DẦU Ở ĐẦU BẰNG DẦU GỘI KETOCONAZOLE 2% KẾT HỢP CALCIPOTRIOL VÀ BETAMETHASONE BÔI TẠI CHỖ". Tạp chí Da liễu học Việt Nam 34 (16 червня 2022): 5–14. http://dx.doi.org/10.56320/tcdlhvn.v34i.27.

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TÓM TẮT Mục tiêu: Đánh giá và so sánh hiệu quả điều trị bệnh viêm da dầu ở đầu mức độ trung bình đến rất nặng bằng dầu gội ketoconazole 2% kết hợp bôi tại chỗ calcipitriol và betamethasone với calcipitriol và betamethasone bôi tại chỗ đơn độc . Đối tượng và phương pháp: Thử nghiệm lâm sàng đối chứng ngẫu nhiên: 83 bệnh nhân viêm da dầu ở đầu mức độ từ trung bình đến rất nặng được phân ngẫu nhiên vào 2 nhóm: nhóm 1 sử dụng bôi tại chỗ calcipotriol và betamethasone kết hợp với dầu gội ketoconazol 2% trong 4 tuần sau đó duy trì dầu gội ketoconazole trong 4 tuần tiếp theo, nhóm 2 chỉ s

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Assegaf, Tengku SDIS, Nelva K. Jusuf, Yunita S. Pane, et al. "Anti-dandruff effects of butterfly pea flowers (Clitoria ternatea)-based shampoo: A pretest-posttest control study." Narra J 4, no. 2 (2024): e876. http://dx.doi.org/10.52225/narra.v4i2.876.

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Butterfly pea flower (Clitoria ternatea) may serve as an alternative anti-dandruff treatment; however, its effects on Malassezia spp. remain unexplored. The aim of this study was to explore the effects of C. ternatea as an herbal-based anti-dandruff treatment on Malassezia spp. DNA expression, plakoglobin levels, IL-8 levels, sebum levels, dandruff severity scores, adverse effects, and patient satisfaction. An experimental study with a pretest-posttest control design was conducted at Outpatient Clinic of Dermatology and Venereology, Arifin Achmad Hospital, Pekanbaru, Indonesia, from November 2

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Ketaren, Divanya Regatha, Suhartomi Suhartomi, Qori Fadillah, Joice Sonya Gani Panjaitan, Siti Syarifah, and Jenny Ria Sihombing. "PERBANDINGAN OBAT ANTI JAMUR KETOCONAZOLE DAN SALEP 2-4 PADA KASUS TINEA PEDIS DI TEMPAT PEMBUANGAN AKHIR SAMPAH TERJUN KOTA MEDAN." Kieraha Medical Journal 6, no. 2 (2024): 122–28. https://doi.org/10.33387/kmj.v6i2.9100.

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Tinea Pedis merupakan salah satu infeksi jamur superfisial kulit yang paling umum di seluruh dunia yang bersifat menular dan berulang. Infeksi ini sering kali tertular secara kontak langsung dengan spora organisme penyebab atau bagian kulit yang terinfeksi. Prevalensi global tinea pedis diperkirakan sekitar 3% dengan risiko seumur hidup mencapai 70%. Prevalensi pada remaja dan dewasa lebih tinggi dibandingkan pada anak-anak. Kejadian tertinggi terjadi antara usia 16 dan 45 tahun saat aktivitas tinggi. Tujuan penelitian ini adalah untuk melihat perbandingan efektivitas antara obat anti jamur ke

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Whitehouse, L. W., A. P. Pakuts, C. J. Paul, R. W. Mueller, and B. H. Thomas. "Hepatic effects of ketoconazole in the male Swiss Webster mouse: temporal changes in drug metabolic parameters." Canadian Journal of Physiology and Pharmacology 68, no. 8 (1990): 1136–42. http://dx.doi.org/10.1139/y90-170.

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There have been conflicting observations regarding the effects of ketoconazole on hepatic metabolism. The objectives of these studies were to determine whether ketoconazole was an enzyme inducer or inhibitor in the mouse and then to establish the time frame of these ketoconazole-induced enzyme changes. Ketoconazole was administered (150 mg/kg p.o. × 4 days) to male Swiss Webster mice. Biochemical observations over a period of 6 days following treatment indicated that ketoconazole had a temporal biphasic effect on the liver. Although liver weight and microsomal protein were elevated, all other

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Millikan, Randall, Luis Baez, Tarit Banerjee, et al. "Randomized phase 2 trial of ketoconazole and ketoconazole/doxorubicin in androgen independent prostate cancer." Urologic Oncology: Seminars and Original Investigations 6, no. 3 (2001): 111–15. http://dx.doi.org/10.1016/s1078-1439(00)00123-x.

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Sugiharta, Sudrajat, and Widia Ningsih. "Evaluasi Stabilitas Sifat Fisika Kimia Sediaan Krim Ketoconazole dengan Metode Stabilitas Penyimpanan Jangka Panjang." Majalah Farmasetika 6 (December 30, 2021): 162. http://dx.doi.org/10.24198/mfarmasetika.v6i0.36707.

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Mutu sediaan obat penting dipertahankan selama proses pembuatan, penyimpanan hingga digunakan. Stabilitas sediaan krim merupakan salah satu kriteria yang penting dari mutu sediaan tersebut karena akan berdampak pada efektifitas, keamanan dan mutu produk pada saat digunakan oleh masyarakat. Penelitian ini bertujuan untuk menguji stabilitas sifat fisika sediaan krim ketoconazole dengan metode stabilitas penyimpanan jangka panjang (real time). Penelitian menggunakan praeksperimental dengan rancangan one shot case study dengan pengujian stabilitas jangka panjang sediaan krim ketoconazole selama 42

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SK, Srivastava. "Development and Evaluation of Antifungal Efficacy of Ketoconazole Pharmacosome." Bioequivalence & Bioavailability International Journal 7, no. 2 (2023): 1–13. http://dx.doi.org/10.23880/beba-16000216.

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Pharmacosomes are neutral colloidal, lipid vesicular drug delivery system having both negative & positive charge that enhance the bioavailability of drugs by enhacing their solubility both in aqueous as well as non-aqueous phase, additionally reduce gastrointestinal toxicity of drug. Ketoconazole is an imidazole derivative agent which is used both in the treatment of topical or systematic fungal infections with fungi static activity against dermatophytes, yeasts and other pathogenic fungi. Ketoconazole is Biopharmaceutical classification system (BCS) class II drugs that display pH dependen

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Okello, D. O., and R. Goodgame. "KETOCONAZOLE FOR SUBCUTANEOUS PHYCOMYCOSIS." Lancet 332, no. 8616 (1988): 911. http://dx.doi.org/10.1016/s0140-6736(88)92517-2.

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17

Dandona, P., J. Mohiuddin, and H. G. Prentice. "KETOCONAZOLE AND ADRENOCORTICAL SECRETION." Lancet 325, no. 8422 (1985): 227. http://dx.doi.org/10.1016/s0140-6736(85)92073-2.

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Sadati, Maryam Sadat, Fateme Alesana, Maryam Hekmat, and Mohammad Mahdi Parvizi. "Efficacy of Topical Rosemary Extract Lotion Versus Topical 2% Ketoconazole Lotion in the Treatment of Seborrheic Dermatitis: A Double Blind Randomized Controlled Clinical Trial." Dermatology Practical & Conceptual 14, no. 4 (2024): e2024242. http://dx.doi.org/10.5826/dpc.1404a242.

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Introduction: Seborrheic dermatitis manifests as greasy, itchy lesions, commonly affecting sebum-rich areas like the scalp and face. Its prevalence is 11.6% in the general population, with various internal and environmental factors contributing to its development. Objectives: This study aimed to compare the efficacy of rosemary extract lotion in the treatment of seborrheic dermatitis in comparison with topical 2% ketoconazole lotion. Methods: This double-blind, randomized clinical trial included 42 patients with scalp seborrheic dermatitis, divided into rosemary and ketoconazole lotion groups.

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Hassan, Shahid, and Ashutosh Ranjan. "Therapeutic efficacy of topical luliconazole versus topical ketoconazole in the treatment of pityriasis versicolor patients: a hospital based comparative study." International Journal of Research in Dermatology 6, no. 2 (2020): 248. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20200606.

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<p class="abstract"><strong>Background:</strong> To evaluate the clinical efficacy of 1% topical luliconazole versus 2% topical ketoconazole in pityriasis versicolor patients.</p><p class="abstract"><strong>Methods:</strong> Mycological examination of all the pityriasis versicolor patient was done by using skin scrapings were collected from the skin lesions to prepare for 10% KOH mount, which was examined under the microscope to note the findings as KOH mount positive or negative for Malassezia fungi. KOH mount positive or negative was noted at 0 days,

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Mohite, Amruta, Anil S. Gugle, Rahul Kote, and Vikrant M. Jadhav. "A Comparative Study of Efficacy, Safety and Relapse Rate of Three Drugs; Systemic Ketoconazole, Systemic Itraconazole and Topical Oxiconazole in the Treatment of Pityriasis Versicolor." MVP Journal of Medical Sciences 2, no. 2 (2015): 76. http://dx.doi.org/10.18311/mvpjms/2015/v2/i2/778.

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<strong>Aim</strong>: The aim of our study was to evaluate the efficacy, safety and relapse rate of systemic Ketoconazole, systemic Itraconazole and topical Oxiconazole in the treatment of pityriasis versicolor. <strong>Study design</strong>: 94 patients who had pityriasis versicolor were included in the study. The patients were given Ketoconazole, Itraconazole and Oxiconazole randomly and were followed up at the interval of 15 days, 1 month and 3 months for assessement of clinical and mycological cure. <strong>Results</strong>: In assessment of clinical par

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Lee, J. S., R. A. Newman, S. M. Lippman, et al. "Phase I evaluation of all-trans retinoic acid with and without ketoconazole in adults with solid tumors." Journal of Clinical Oncology 13, no. 6 (1995): 1501–8. http://dx.doi.org/10.1200/jco.1995.13.6.1501.

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PURPOSE All-trans retinoic acid (RA) induces accelerated plasma all-trans RA clearance, presumably via cytochrome P450 enzymes. This accelerated metabolism has been shown to be inhibited in the short term by the cytochrome P450 inhibitor ketoconazole. This study was conducted to evaluate the efficacy of ketoconazole in maintaining plasma all-trans RA levels over time. PATIENTS AND METHODS Using a randomized crossover study design, we randomly assigned six patients to receive all-trans RA (45 mg/m2 orally twice per day for 14 days of a 21-day cycle) for cycle 1 and the same dose of all-trans RA

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Liu, Ping-Yen, Cheng-Han Lee, Li-Jen Lin, and Jyh-Hong Chen. "Refractory Anaphylactic Shock Associated with Ketoconazole Treatment." Annals of Pharmacotherapy 39, no. 3 (2005): 547–50. http://dx.doi.org/10.1345/aph.1e465.

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OBJECTIVE: To report a rare but severe reaction of refractory anaphylactic shock with ketoconazole treatment—associated hypotensive episodes in an elderly patient. CASE SUMMARY: A 72-year-old woman received antifungal therapy for her almost completely occluded cornea infected with Candida albicans. She was initially prescribed oral ketoconazole 200 mg twice daily. She developed hypotension over the first 2 days of therapy (BP 136/82 mm Hg at baseline; 90/50 mm Hg on day 2). Severe hypotension (BP 90/49 mm Hg) unresponsive to fluid therapy or high-dose dopamine developed on day 4 of therapy. An

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De Coster, R., M. C. Coene, C. Haelterman, D. Beerens, and N. Goeminne. "Effects of high-dose ketoconazole treatment on adrenal mineralocorticoid biosynthesis in dogs and rats." Acta Endocrinologica 115, no. 3 (1987): 423–31. http://dx.doi.org/10.1530/acta.0.1150423.

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Abstract. At high doses, ketoconazole blocks both testicular and adrenal androgen biosyntheses and partially inhibits the glucocorticoid production. To investigate the effects of this imidazole derivative on the mineralocorticoid biosynthesis, 7 male mongrel dogs received a single oral dose of 15 mg/kg of ketoconazole or placebo, in a cross-over way. From 2 to 4 h after treatment, an iv infusion of angiotensin II (10 ng/kg per min) was performed. Ketoconazole treatment significantly blunted the aldosterone and cortisol increment, whereas 18-hydroxycorticosterone, corticosterone, 11-deoxycortic

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Annisa, Viviane, Teuku Nanda Saifullah Sulaiman, Akhmad Kharis Nugroho, and Agung Endro Nugroho. "A novel formulation of ketoconazole entrapped in alginate with anionic polymer beads for solubility enhancement: Preparation and characterization." Pharmacia 70, no. (4) (2023): 1423–38. https://doi.org/10.3897/pharmacia.70.e108120.

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Ketoconazole has low solubility in intestinal pH, whereas drug absorption is largest in the small intestine, which can reduce the bioavailability of the drug. Alginate can be combined with a suitable polymer and cross-linked with divalent ions and another polymer to enhance the solubility of the drug. Ketoconazole could be loaded into a matrix polymer consisting of alginate and anionic polymer through hydrogen bonds formed with the N atom of the ketoconazole. The method employed to produce ketoconazole beads involved ionic gelation with CaCl<sub>2</sub> as a cross- linking agent, and various p

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Sharp, Nicholas J. H., and Martin Sullivan. "Use of ketoconazole in the treatment of canine nasal aspergillosis." Journal of the American Veterinary Medical Association 194, no. 6 (1989): 782–86. https://doi.org/10.2460/javma.1989.194.06.782.

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Summary Fifteen dogs with nasal aspergillosis were treated with ketoconazole (5 mg/kg of body weight, q 12 h, po) for 2 to 18 weeks. Four dogs whose conditions deteriorated during treatment received ketoconazole for less than the prescribed 6 weeks. Six months or more later, only 47% of the dogs were determined to be disease-free, on the basis of no fungal growth on culture. It was concluded that ketoconazole at this dosage is a useful treatment for canine nasal aspergillosis, but is no more effective than thiabendazole.

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McLelland, J., and S. Shuster. "Topical ketoconazole does not potentiate oral cyclosporin A in allergic contact dermatitis." Acta Dermato-Venereologica 72, no. 4 (1992): 285. http://dx.doi.org/10.2340/0001555572285.

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Cyclosporin A is an effective drug but its use is limited by its side effects. Since oral ketoconazole inhibits the metabolism of oral cyclosporin, we set out to find out whether topical ketoconazole would enhance the effect in the skin of oral cyclosporin. Five patients with contact allergic dermatitis (CAD) were given a 6-day course of cyclosporin (1 mg/kg/day) and applied 2% ketoconazole cream to an area on one arm and the inert base to the other. Serial dilutions of the relevant allergen were applied to the arms at 3 days for 48 hours, and the responses were measured objectively a day late

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Zhao, Tingting, Dalong Wang, Shan Zhao, et al. "Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 2." Current Drug Metabolism 22, no. 5 (2021): 391–98. http://dx.doi.org/10.2174/1389200222666210210115509.

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Background: Both clotrimazole and ketoconazole have been verified to have an inhibitory effect on CYP3A4. hCE2 is an enzyme closely related to the side effects of several anti-cancer drugs. However, the interactions between hCE2, clotrimazole, and ketoconazole remain unclear. Objective: The objective of this study was to investigate and compare the inhibition behaviors of the two antifungal agents, ketoconazole and clotrimazole, on the human liver microsome hCE2 and to explore their underlying mechanism. Methods: The inhibitory effects were investigated in human liver microsomes (HLMs) using f

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Rolz-Cruz, Gabriela, and Alexa B. Kimball. "Ketoconazole 2% foam for treatment of seborrheic dermatitis." Expert Review of Dermatology 3, no. 1 (2008): 15–21. http://dx.doi.org/10.1586/17469872.3.1.15.

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Piepponen, T., R. Suhonen, T. Rantanen, K. Blomqvist, R. Pajarre, and L. Lehtonen. "Treatment of dandruff with a ketoconazole 2% shampoo." Journal of Dermatological Treatment 3, no. 3 (1992): 119–23. http://dx.doi.org/10.3109/09546639209088704.

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Aljabre, Salih H. M. "Trichoptilosis Caused by Misuse of Ketoconazole 2% Shampoo." International Journal of Dermatology 32, no. 2 (1993): 150–51. http://dx.doi.org/10.1111/j.1365-4362.1993.tb01462.x.

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Tawfik, KhaledM, WaleedA Mahmmoud, and AmiraG E. Ali. "Ketoconazole 2% cream versus a combination of ketoconazole 2% cream and adapalene 0.1% gel in the treatment of pityriasis versicolor." Al-Azhar Assiut Medical Journal 20, no. 1 (2022): 100. http://dx.doi.org/10.4103/azmj.azmj_97_21.

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Rizwan, Muhammad, Amanat Ali, Najia Ahmad, and Moizza Tahir. "Topical Betamethasone Valerate 0.1% W/V vs. Topical Ketoconazole 2% W/V: A Comparison of Efficacy in Patients of Seborrheic Dermatitis." Pakistan Armed Forces Medical Journal 72, no. 3 (2022): 1082–85. http://dx.doi.org/10.51253/pafmj.v72i3.7430.

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Objective: To compare the efficacy of topical Betamethasone valerate 0.1% w/v and topical Ketoconazole 2% w/v in patients of seborrheic dermatitis. Study Design: Comparative prospective study. Place and Duration of Study: Department of Dermatology, Pak Emirates Military Hospital Rawalpindi Pakistan from Feb to Aug 2019. Methodology: A total of 80 patients of both genders with seborrheic dermatitis were included. Patients were divided into two groups randomly, with 40 patients in each group. Group-A patients were given topical Betamethasone valerate 0.1% w/v, while patients in

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Wei, Jianming, Yu Li, Li Zhang, et al. "Effectiveness of Chuzhi Shengfa Tablets Combined with Ketoconazole Shampoo and Chuzhi Shengfa Tablets Combined with 5% Minoxidil Foam in the Treatment of Male Androgenetic Alopecia." Journal of Clinical and Nursing Research 8, no. 9 (2024): 201–7. http://dx.doi.org/10.26689/jcnr.v8i9.8394.

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Objective: To investigate the clinical efficacy and safety of Chuzhi Shengfa Tablets combined with ketoconazole shampoo and Chuzhi Shengfa Tablets combined with 5% minoxidil foam in the treatment of male androgenetic alopecia. Methods: From July 2022 to July 2023, 120 male patients with androgenetic alopecia were selected from our Department of Dermatology and randomly divided into Control Group 1, Control Group 2, Observation Group 1, and Observation Group 2, with 30 patients in each group. Control Group 1 was treated with ketoconazole shampoo, Control Group 2 with 5% minoxidil foam, Observat

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Reina, L. Jimenez, A. Leal-Cerro, J. Garcia, P. P. Garcia-Luna, R. Astorga, and G. Bernal. "In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome." Acta Endocrinologica 121, no. 2 (1989): 185–90. http://dx.doi.org/10.1530/acta.0.1210185.

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Abstract. The direct effects of ketoconazole on the secretion of ACTH by human pituitary adenoma cells from 2 patients with Nelson's syndrome were studied in vitro. Stereologically quantified, intracellular changes affect the surface density of the endoplasmic reticulum (it decreased by 73%), the volume density of the secretion granules (it decreased by 49%), and the volume density of lysosomes (it decreased by 67%). The hormone released in the culture medium decreased depending on the doses of ketoconazole used; 10 μmol/l decreased ACTH levels by 31%. These data show that ketoconazole induce

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Aldhalimi, Muhsin A., Najah R. Hadi, and Fadaa A. Ghafil. "Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice." ISRN Pharmacology 2014 (March 9, 2014): 1–5. http://dx.doi.org/10.1155/2014/575423.

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Recently topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia. Minoxidil is a vasodilatory medication used primarily as antihypertensive drug. It was discovered to have the side effect of hair growth and reversing baldness. Tretinoin is commonly used topically for acne treatment and in the treatment of photoaging. It is used by some as hair loss treatment. Objective. To compare the stimulatory effect of Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on hair growth in a mouse model. Materials and Methods. Coat hairs on the dorsal s

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El-Mofty, Hala Mohamed, Mohamad Amr Salah Eddin Abdelhakim, Mohamed Farid El-Miligi, Mohamed A. El-Nabarawi, and Islam Ahmed Hamed Khalil. "A New Combination Formula for Treatment of Fungal Keratitis: An Experimental Study." Journal of Ophthalmology 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/173298.

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Objective. To formulate and evaluate slow release ketoconazole and ketorolac to treat fungal keratitis and associated inflammation.Methods. Experimental study with the following outcome measures.Pharmaceutical Evaluation. Mucoadhesive gels containing ketoconazole and ketorolac were used.Microbiological in vitroevaluationwas performed using cup method.In vivo evaluationwas performed on 24 rabbits divided into 2 groups, 12 rabbits each, group A (fast release formula; 6 times daily) and group B (slow release formula; 3 times daily). Each group was divided into two subgroups (6 rabbits each). Both

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KARL STALLA, GÜNTER, JOHANNA STALLA, MARTIN HUBER, et al. "Ketoconazole Inhibits Corticotropic Cell Functionin Vitro*." Endocrinology 122, no. 2 (1988): 618–23. http://dx.doi.org/10.1210/endo-122-2-618.

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Whitehouse, L. W., A. Menzies, R. Mueller, and R. Pontefract. "Ketoconazole-induced hepatic phospholipidosis in the mouse and its association with de-N-acetyl ketoconazole." Toxicology 94, no. 1-3 (1994): 81–95. http://dx.doi.org/10.1016/0300-483x(94)90030-2.

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Palócz, Orsolya, Orsolya Farkas, Paul Clayton, and György Csikó. "Changes in cytochrome P450 gene expression and enzyme activity induced by xenobiotics in rabbits in vivo and in vitro." World Rabbit Science 25, no. 2 (2017): 173. http://dx.doi.org/10.4995/wrs.2017.4574.

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As considerable inter-species differences exist in xenobiotic metabolism, developing new pharmaceutical therapies for use in different species is fraught with difficulties. For this reason, very few medicines have been registered for use in rabbits, despite their importance in inter alia meat and fur production. We have developed a rapid and sensitive screening system for drug safety in rabbits based on cytochrome P450 enzyme assays, specifically CYP1A1, CYP1A2 and CYP3A6, employing an adaptation of the luciferin-based clinical assay currently used in human drug screening. Short-term (4-h) cul

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White, M. C., and P. Kendall-Taylor. "ADRENAL HYPOFUNCTION IN PATIENTS TAKING KETOCONAZOLE." Lancet 325, no. 8419 (1985): 44–45. http://dx.doi.org/10.1016/s0140-6736(85)90988-2.

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Buchi, Kenneth N., Philip D. Gray, and Keith G. Tolman. "Ketoconazole hepatotoxicity: An in vitro model." Biochemical Pharmacology 35, no. 16 (1986): 2845–47. http://dx.doi.org/10.1016/0006-2952(86)90204-2.

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Siddik, Muhammad Baihaqi, Lia Yulia Budiarti, and Edyson Edyson. "PERBANDINGAN EFEKTIVITAS ANTIFUNGI ANTARA EKSTRAK METANOL KULIT BATANG KASTURI DENGAN KETOKONAZOL 2% TERHADAP Candida albicans IN VITRO." Berkala Kedokteran 12, no. 2 (2016): 271. http://dx.doi.org/10.20527/jbk.v12i2.1877.

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Abstract: Candida albicans is the most common cause of candidacies. Ketoconazole is one of the main options treatment of candidiasis, but is reported to have experienced resistance and hepatotoxic. Extract methanol bark of kasturi contains the same active substance with, Mango that is phenolic groups, terpenoids, and saponins that are antifungal. The purpose of this study was to determine differences in the concentration of the methanol extract of the bark of kasturi with ketoconazole 2% against Candida albicans in vitro. This study was true laboratory experimental by using randomize post test

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Pangesty, Vika, Ika Dyah Kurniati, and Kanti Ratnaningrum. "Effectiveness of Bitter melon (Momordica charantia L) Extract on Growth of Trichopyton rubrum: In Vitro Study." MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan 10, no. 1 (2023): 19. http://dx.doi.org/10.26714/magnamed.10.1.2023.19-26.

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Trichophyton rubrum is type of fungus that most often causes superficial fungal infections. Development of herbal ingredients as antifungal therapy is carried out to find alternative therapies for fungal infections. Bitter melon contains various compounds that have potential to be used as antifungals, including flavonoids and saponins. The aim of this study was to determine the effect of bitter melon extract (Momordica charantia L) on the growth of Trichopyton rubrum. This study used bitter melon extract at concentrations of 5%, 25%, 50%, 75% and 100%. Ketoconazole concentrations of 2% was use

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Mohamed, Amal, Aza Hassan, Magdy Amer, and El-Said Abdel-Aziz. "The effects of oral ketoconazole and griseofulvin on the fertility of male rabbits." Mansoura Veterinary Medical Journal 21, no. 2 (2020): 32–38. http://dx.doi.org/10.35943/mvmj.2020.21.2.0203.

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Objectives: To investigate possible side effects of ketoconazole and griseofulvin on fertility of clinically healthy male rabbits. Design: Randomized controlled experimental study. Animals: Thirty mature male rabbits. Procedures: Rabbits were randomly allocated into three equal sized groups (10 animals each). The first group served as a control group (received no treatment), the second group received griseofulvin (25 mg/kg B.W) orally for 30 days, and the third group received ketoconazole (50 mg/kg B.W) orally for 30 days. Semen samples were collected after 1 day, 1 week and 2 weeks post-admin

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Moriello, Karen A. "In vitro efficacy of shampoos containing miconazole, ketoconazole, climbazole or accelerated hydrogen peroxide against Microsporum canis and Trichophyton species." Journal of Feline Medicine and Surgery 19, no. 4 (2016): 370–74. http://dx.doi.org/10.1177/1098612x15626197.

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Objectives The objective was to evaluate the antifungal efficacy of shampoo formulations of ketoconazole, miconazole or climbazole and accelerated hydrogen peroxide wash/rinse against Microsporum canis and Trichophyton species spores. Methods Lime sulfur (1:16)-treated control, enilconazole (1:100)-treated control, accelerated hydrogen peroxide (AHP 7%) 1:20 and a 1:10 dilution of shampoo formulations of miconazole 2%, miconazole 2%/chlorhexidine gluconate 2–2.3%, ketoconazole 1%/chlorhexidine 2%, climbazole 0.5%/chlorhexidine 3% and sterile water-untreated control were tested in three experim

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Greer, Donald L. "Successful treatment of tinea capitis with 2% ketoconazole shampoo." International Journal of Dermatology 39, no. 4 (2000): 302–4. http://dx.doi.org/10.1046/j.1365-4362.2000.00885.x.

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Cauwenbergh, Geert, Piet De Doncker, Peter Schrooten, and Hugo Degreef. "Treatment of Dandruff With a 2% Ketoconazole Scalp Gel." International Journal of Dermatology 25, no. 8 (1986): 541. http://dx.doi.org/10.1111/j.1365-4362.1986.tb00877.x.

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Mota, Crystiane Rodrigues Araújo, Karla Carvalho Miranda, Janine de Aquino Lemos, et al. "Comparison of in vitro activity of five antifungal agents against dermatophytes, using the agar dilution and broth microdilution methods." Revista da Sociedade Brasileira de Medicina Tropical 42, no. 3 (2009): 250–54. http://dx.doi.org/10.1590/s0037-86822009000300003.

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The purpose of this study was to compare the agar dilution and broth microdilution methods for determining the minimum inhibitory concentration (MIC) of fluconazole, itraconazole, ketoconazole, griseofulvin and terbinafine for 60 dermatophyte samples belonging to the species Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum canis. The percentage agreement between the two methods, for all the isolates with < 2 dilutions that were tested was 91.6% for ketoconazole and griseofulvin, 88.3% for itraconazole, 81.6% for terbinafine and 73.3% for fluconazole. One hundred percent agre

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Davey, Kate G., Ann D. Holmes, Elizabeth M. Johnson, Adrien Szekely, and David W. Warnock. "Comparative Evaluation of FUNGITEST and Broth Microdilution Methods for Antifungal Drug Susceptibility Testing of Candida Species and Cryptococcus neoformans." Journal of Clinical Microbiology 36, no. 4 (1998): 926–30. http://dx.doi.org/10.1128/jcm.36.4.926-930.1998.

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The FUNGITEST method (Sanofi Diagnostics Pasteur, Paris, France) is a microplate-based procedure for the breakpoint testing of six antifungal agents (amphotericin B, flucytosine, fluconazole, itraconazole, ketoconazole, and miconazole). We compared the FUNGITEST method with a broth microdilution test, performed according to National Committee for Clinical Laboratory Standards document M27-A guidelines, for determining the in vitro susceptibilities of 180 isolates ofCandida spp. (50 C. albicans, 50C. glabrata, 10 C. kefyr, 20C. krusei, 10 C. lusitaniae, 20C. parapsilosis, and 20 C. tropicalisis

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Sun, Xianyun, Kangji Wang, Xinxu Yu, et al. "Transcription Factor CCG-8 as a New Regulator in the Adaptation to Antifungal Azole Stress." Antimicrobial Agents and Chemotherapy 58, no. 3 (2013): 1434–42. http://dx.doi.org/10.1128/aac.02244-13.

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ABSTRACTAntifungal azoles are widely used for controlling fungal infections. Fungi are able to change the expression of many genes when they adapt to azole stress, and increased expression of some of these genes can elevate resistance to azoles. However, the regulatory mechanisms behind transcriptional adaption to azoles in filamentous fungi are poorly understood. In this study, we found that deletion of the transcription factor geneccg-8, which is known to be a clock-controlled gene, madeNeurospora crassahypersensitive to azoles. A comparative genome-wide analysis of the responses to ketocona

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