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Journal articles on the topic 'And apigenin'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Shailendra, Boini, and Puligilla Shankaraiah. "Antioxidant and Alpha Amylase Inhibitory Activity of Apigenin in Alloxan Induced Diabetic Rats." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 12 (2024): 125–31. http://dx.doi.org/10.56557/upjoz/2024/v45i124111.

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Purpose: to study the antioxidant, inhibitory activity of alpha amylase, antidiabetic, effects of flavonoid Apigeninin in diabetic rats. Methods: The effect of Apigeninon on blood glucose and antioxidant activities were estimated in alloxan induced diabetic and treated rats. The α-amylase inhibitory activity in the serum was assessed after oral administration of 7thday, 14th day, and 21st days treatment of Apigenin. Results: The Apigenin was reduced the serum glucose, α-amylase levels and increased antioxidant levels significantly (P<0.05) in Apigenin alone and combination with Metformin tr

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2

Wang, Minqian, Jenni Firrman, LinShu Liu, and Kit Yam. "A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota." BioMed Research International 2019 (October 16, 2019): 1–18. http://dx.doi.org/10.1155/2019/7010467.

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Apigenin is a flavonoid of low toxicity and multiple beneficial bioactivities. Published reviews all focused on the findings using eukaryotic cells, animal models, or epidemiological studies covering the pharmacokinetics, cancer chemoprevention, and drug interactions of apigenin; however, no review is available on the antimicrobial effects of apigenin. Research proves that dietary apigenin passes through the upper gastrointestinal tract and reaches the colon after consumption. For that reason, it is worthwhile to study the potential interactions between apigenin and human gut microbiota. This

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Bian, Shichang, Hongjuan Wan, Xinyan Liao, and Weisheng Wang. "Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota." Mediators of Inflammation 2020 (October 5, 2020): 1–9. http://dx.doi.org/10.1155/2020/7141970.

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The flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin’s potential mechanism of action exerted through its effects upon gut microbiota. The size and quantity of tumors were reduced significantly in the apigenin treatment group. Using 16S rRNA high-throughput sequencing of fecal samples, the composition of gut microbiota was significantly affected by api

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Golonko, Aleksandra, Adam Jan Olichwier, Agata Szklaruk, et al. "Apigenin’s Modulation of Doxorubicin Efficacy in Breast Cancer." Molecules 29, no. 11 (2024): 2603. http://dx.doi.org/10.3390/molecules29112603.

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Apigenin, a naturally derived flavonoid, is increasingly being acknowledged for its potential therapeutic applications, especially in oncology. This research explores apigenin’s capacity to modulate cancer cell viability, emphasizing its roles beyond its minimal antioxidant activity attributed to its basic molecular structure devoid of hydroxyl groups. We investigated apigenin’s effects on two breast cancer cell lines, estrogen-dependent MCF-7 and non-estrogen-dependent MDA-MB-231 cells. Our findings reveal that apigenin exerts a dose-dependent cytotoxic and anti-migratory impact on these cell

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5

Sánchez-Marzo, Pérez-Sánchez, Ruiz-Torres, et al. "Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers." International Journal of Molecular Sciences 20, no. 9 (2019): 2148. http://dx.doi.org/10.3390/ijms20092148.

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Ultraviolet (UV) radiation, especially types A (UVA) and B (UVB), is one of the main causes of skin disorders, including photoaging and skin cancer. Ultraviolent radiation causes oxidative stress, inflammation, p53 induction, DNA damage, mutagenesis, and oxidation of various molecules such as lipids and proteins. In recent decades, the use of polyphenols as molecules with an antioxidant and anti-inflammatory capacity has increased. However, some of these compounds are poorly soluble, and information regarding their absorption and bioavailability is scarce. The main objective of this study was

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Lestari, Dwintha, Elin Yulinah Sukandar, and Irda Fidrianny. "IN SILICO STUDY OF APIGENIN AND APIGETRIN AS INHIBITOR OF 3-HYDROXY-3-METHYL-GLUTAYL-COENZYME A REDUCTASE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 11 (2017): 284. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.20493.

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Objective: The objectives of this research were to investigate in silico interaction between apigenin and apigetrin with 3-hydroxy-3-methyl-glutayl-coenzyme A (HMG Co-A) reductase, to find the most favorable binding site as well as to predict the binding mode.Materials and Methods: Docking calculation was performed by branded Sony Vaio PC Linux Ubuntu 14.04 LTS. The binding process based on the best docking result with HMG Co-A reductase was presented in two-dimensional diagram. Statin, atorvastatin, and R-mevalonate were used as standard.Results: Binding affinity and inhibition constant of R-

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7

Ivanov, Marija, Abhilash Kannan, Dejan S. Stojković, et al. "Flavones, Flavonols, and Glycosylated Derivatives—Impact on Candida albicans Growth and Virulence, Expression of CDR1 and ERG11, Cytotoxicity." Pharmaceuticals 14, no. 1 (2020): 27. http://dx.doi.org/10.3390/ph14010027.

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Due to the high incidence of fungal infections worldwide, there is an increasing demand for the development of novel therapeutic approaches. A wide range of natural products has been extensively studied, with considerable focus on flavonoids. The antifungal capacity of selected flavones (luteolin, apigenin), flavonols (quercetin), and their glycosylated derivatives (quercitrin, isoquercitrin, rutin, and apigetrin) along with their impact on genes encoding efflux pumps (CDR1) and ergosterol biosynthesis enzyme (ERG11) has been the subject of this study. Cytotoxicity of flavonoids towards primar

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8

Charrière, Karine, Vincent Schneider, Manon Perrignon-Sommet, et al. "Exploring the Role of Apigenin in Neuroinflammation: Insights and Implications." International Journal of Molecular Sciences 25, no. 9 (2024): 5041. http://dx.doi.org/10.3390/ijms25095041.

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Neuroinflammation, a hallmark of various central nervous system disorders, is often associated with oxidative stress and neuronal or oligodendrocyte cell death. It is therefore very interesting to target neuroinflammation pharmacologically. One therapeutic option is the use of nutraceuticals, particularly apigenin. Apigenin is present in plants: vegetables (parsley, celery, onions), fruits (oranges), herbs (chamomile, thyme, oregano, basil), and some beverages (tea, beer, and wine). This review explores the potential of apigenin as an anti-inflammatory agent across diverse neurological conditi

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9

He, Xiangfei, Yibo Wen, Qingwei Wang та ін. "Apigenin Nanoparticle Attenuates Renal Ischemia/Reperfusion Inflammatory Injury by Regulation of miR-140-5p/CXCL12/NF-κB Signaling Pathway". Journal of Biomedical Nanotechnology 17, № 1 (2021): 64–77. http://dx.doi.org/10.1166/jbn.2021.3010.

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Apigenin as a natural flavonoid product has been proved previously to play a renoprotective effect during ischemia/reperfusion injury (IRI), but the particular mechanisms involving the positive effects of apigenin remain totally unclear. The study investigated apigenin's roles and underlying biological mechanisms in IR-induced acute kidney injury (AKI). Thirty-six mice received a right nephrectomy and clamping of the left renal artery for 30 minutes, and then perfusion for 24 h. Apigenin was loaded onto a biodegradable polymer carrier (nanoparticle) to enhance its bioavailability. Mice were su

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10

Abid, Rameesha, Shakira Ghazanfar, Arshad Farid, et al. "Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways." Molecules 27, no. 13 (2022): 4304. http://dx.doi.org/10.3390/molecules27134304.

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Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional activities that aid in the prevention of infectious diseases in many mammalian bodies and promote tumor growth inhibition. Apigenin is a flavonoid with low toxicities and numerous bioactive properties due to which it has been considered as a traditional medicine for decades. Apigenin shows synergistic effects in combined treatment with sorafenib in the HepG2 human cell line (HCC) in less time and statistically reduces the viability of tumor cells, migration, gene expression and apoptosis. The combinatio

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Tong, Xin, Rukiyah T. Van Dross, Adnan Abu-Yousif, Aubrey R. Morrison, and Jill C. Pelling. "Apigenin Prevents UVB-Induced Cyclooxygenase 2 Expression: Coupled mRNA Stabilization and Translational Inhibition." Molecular and Cellular Biology 27, no. 1 (2006): 283–96. http://dx.doi.org/10.1128/mcb.01282-06.

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ABSTRACT Cyclooxygenase 2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins, and COX-2 overexpression plays an important role in carcinogenesis. Exposure to UVB strongly increased COX-2 protein expression in mouse 308 keratinocytes, and this induction was inhibited by apigenin, a nonmutagenic bioflavonoid that has been shown to prevent mouse skin carcinogenesis induced by both chemical carcinogens and UV exposure. Our previous study suggested that one pathway by which apigenin inhibits UV-induced and basal COX-2 expression is through modulation of USF transcriptio

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12

Tsiailanis, Antonios D., Constantinos C. Tellis, Paraskevi Papakyriakopoulou, et al. "Development of a Novel Apigenin Dosage form as a Substitute for the Modern Triple Antithrombotic Regimen." Molecules 28, no. 5 (2023): 2311. http://dx.doi.org/10.3390/molecules28052311.

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The simultaneous administration of three antiplatelet agents has been proposed as an efficient strategy for the secondary prevention of atherothrombotic events and is included in the European guidelines. However, this strategy presented an increased risk of bleeding; therefore, the identification of new antiplatelet agents, with improved efficacy and diminished side effects, is of great importance. In silico studies, UPLC/MS Q-TOF plasma stability, in vitro platelet aggregation experiments, and pharmacokinetic studies were exploited. In the present study, it has been predicted that the flavono

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13

Uysal Yeler, Gülcan, and Zeynep Göktaş. "Luteolin ve Apigenin Fitokimyasallarının Meme Kanseri Üzerine Etkileri." Journal of Nutrition and Dietetics 52, no. 2 (2024): 71–80. http://dx.doi.org/10.33076/2024.bdd.1877.

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Son yıllarda fitokimyasalların sağlık ve hastalıklara karşı etkileri konusunda araştırmalar artmaktadır ve en çok araştırılan konulardan birisi kanserdir. Meme kanseri meme hücrelerinin anormal büyümesi ile karakterizedir ve hormon cevaplarına göre sınıflandırılmaktadır. Bu sınıflandırma tedavinin yönünü ve seyrini etkilemektedir. Luteolin ve apigenin flavonlar sınıfında yer alan fitokimyasallardır ve sebzelerle sıklıkla alınmaktadır. Hem luteolinin hem de apigeninin anti-kanser özellikleri araştırılmaktadır. Bu çalışmada luteolin ve apigenin fitokimyasallarının meme kanserini hangi biyokimyas

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14

BAUMANN, LESLIE S. "Apigenin." Skin & Allergy News 39, no. 3 (2008): 32. http://dx.doi.org/10.1016/s0037-6337(08)70149-9.

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15

Moore, Patrick, Rashida Ginwala, Nikil Revuri, et al. "Nutraceutical Apigenin: mechanism of action associated with its anti-inflammatory activity and regulation of dendritic cell metabolism." Journal of Immunology 198, no. 1_Supplement (2017): 219.12. http://dx.doi.org/10.4049/jimmunol.198.supp.219.12.

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Abstract Flavonoids have a range of biological activities, including anti-inflammatory, anti-carcinogenic, and neuroprotective effects. Apigenin, one such flavonoid abundant in certain plants, has been employed for centuries in the treatment of Parkinson’s, neuralgia, asthma and other diseases owing to the positive health effects attributed to this group of compounds. Due to Apigenin’s relative abundance and low intrinsic toxicity amongst flavonoids, it can be considered as a potential natural treatment for inflammatory disorders of the central nervous system (CNS), such as multiple sclerosis.

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16

Lau, Hazel, Hui Min Koh, Hiranya Dayal, Yi Ren, and Sam Fong Yau Li. "Optimisation of an Aglycone-Enhanced Celery Extract with Germinated Soy Supplementation Using Response Surface Methodology." Foods 10, no. 10 (2021): 2505. http://dx.doi.org/10.3390/foods10102505.

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In this study, the extraction conditions of bioactive aglycones from a celery extract supplemented with germinated soy were optimised by a response surface methodology. For subsequent enzymatic hydrolysis to enhance the apigenin content, increased production of its precursor apigetrin was firstly achieved through acidic extraction at optimal conditions, involving water at pH 1, at 75 °C for 2 h. Subsequently, a central composite design was conducted to analyse the pH (3–11) and temperature (25–35 °C) effects on the aglycone levels (apigenin, daidzein and genistein). The optimal extraction cond

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17

Xia, Feifei, Xin Li, Bin Wang, et al. "Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus." Applied and Environmental Microbiology 82, no. 1 (2015): 87–94. http://dx.doi.org/10.1128/aem.02581-15.

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ABSTRACTPneumonia is one of the most prevalentStaphylococcus aureus-mediated diseases, and the treatment of this infection is becoming challenging due to the emergence of multidrug-resistantS. aureus, especially methicillin-resistantS. aureus(MRSA) strains. It has been reported that LysGH15, the lysin derived from phage GH15, displays high efficiency and a broad lytic spectrum against MRSA and that apigenin can markedly diminish the alpha-hemolysin ofS. aureus. In this study, the combination therapy of LysGH15 and apigenin was evaluatedin vitroand in a mouseS. aureuspneumonia model. No mutual

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Allemailem, Khaled S., Ahmad Almatroudi, Hajed Obaid A. Alharbi, et al. "Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment." Biomedicines 12, no. 6 (2024): 1353. http://dx.doi.org/10.3390/biomedicines12061353.

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Apigenin is a powerful flavone compound found in numerous fruits and vegetables, and it offers numerous health-promoting benefits. Many studies have evidenced that this compound has a potential role as an anti-inflammatory and antioxidant compound, making it a promising candidate for reducing the risk of pathogenesis. It has also been found to positively affect various systems in the body, such as the respiratory, digestive, immune, and reproductive systems. Apigenin is effective in treating liver, lung, heart, kidney, neurological diseases, diabetes, and maintaining good oral and skin health.

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Rakesh, Davella, and Mamidala Estari. "Molecular Docking and Dynamic Simulation Studies of compounds from Rumex vesicarius against Maltase-Glucoamylase to treat type 2 DiabeteS." Annals of R.S.C.B 25, no. 6 (2022): 21067–77. https://doi.org/10.5281/zenodo.7069397.

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The growing number of diabetes cases in India has lately been worrisome, and the potential of certain herbal plants in Indonesia to be anti-diabetic medication candidates has to be appropriately addressed. The MaltaseGlucoamylase objective was investigated with the aim of molecular docking and dynamic simulations of Indiian herbal substances (Rumex vesicarius). In this study the patented medicine, Acarbose, has been utilised as a control. The findings indicate that the affinity to acarbosis (-9,35 and 8,75 kcal/mol respectively) is greater for all the luteoline and apigenin compounds. The stud

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Şanlı, Senem, and Craig Lunte. "Determination of eleven flavonoids in chamomile and linden extracts by capillary electrophoresis." Anal. Methods 6, no. 11 (2014): 3858–64. http://dx.doi.org/10.1039/c3ay41878b.

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A sensitive, dependable, simple and rapid method based on capillary electrophoresis with diode array detection (CE-DAD) was developed for identification and determination of eleven flavonoids (apigetrin, naringin, naringenin, catechin, galangin, apigenin, luteolin, quercetin, myricetin, kaempferol, and kaempferide) in chamomile and linden flower extracts.

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Salehi, Bahare, Alessandro Venditti, Mehdi Sharifi-Rad, et al. "The Therapeutic Potential of Apigenin." International Journal of Molecular Sciences 20, no. 6 (2019): 1305. http://dx.doi.org/10.3390/ijms20061305.

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Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human

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Farhana, Aisha, Abdullah Alsrhani, Yusuf Saleem Khan, Mohammad Salahuddin, Mohammed Ubaidullah Sayeed, and Zafar Rasheed. "Apigenin Provides Structural Protection to Human Fibrinogen against Nitrosative Stress: Biochemical and Molecular Insights." Biomolecules 14, no. 5 (2024): 576. http://dx.doi.org/10.3390/biom14050576.

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Background: Peroxynitrite (ONOO−) is an oxidant linked with several human pathologies. Apigenin, a natural flavonoid known for its health benefits, remains unexplored in relation to ONOO− effects. This study investigated the potential of apigenin to structurally protect fibrinogen, an essential blood clotting factor, from ONOO−-induced damage. Methods: Multi-approach analyses were carried out where fibrinogen was exposed to ONOO− generation while testing the efficacy of apigenin. The role of apigenin against ONOO−-induced modifications in fibrinogen was investigated using UV spectroscopy, tryp

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Ilic, Sanja, Sanja Djakovic, Jelena Cvejic, Mirjana Antov та Zoran Zekovic. "Bioconversion of apigenin-7-O-β-glucoside in aqueous two-phase system". Acta Periodica Technologica, № 36 (2005): 197–202. http://dx.doi.org/10.2298/apt0536197i.

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The study is concerned with the conversion of apigenin-7-O-?-glucoside into apigenin in polyethylene glycol 6000 / dextran 20000 aqueous two-phase system by ?-glucosidase. Apigenin was separated from apigenin-7-O-?-glucoside and ?-glucosidase by their partition into opposite phases. In 14% PEG / 22.5% DEX aqueous two-phase system obtained yield of apigenin in top phase was 108%.

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Torkin, Risa, Jean-François Lavoie, David R. Kaplan, and Herman Yeger. "Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma." Molecular Cancer Therapeutics 4, no. 1 (2005): 1–11. http://dx.doi.org/10.1158/1535-7163.1.4.1.

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Abstract Neuroblastoma is a pediatric tumor accounting for 15% of childhood cancer deaths and has a poor prognosis in children &gt; 1 year of age. We investigated the ability of apigenin, a nonmutagenic dietary flavonoid that has been shown to have antitumor effects in various tumor cell lines, to inhibit growth and induce apoptosis of the human neuroblastoma cell lines NUB-7, LAN-5, and SK-N-BE(2). Apigenin inhibited colony-forming ability and survival, and induced apoptosis of NUB-7 and LAN-5 cells. The presence of the C2-C3 double bond and the 4′-OH group on the flavonoid structure corr

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Zeng, Ping, Bin Liu, Qun Wang, et al. "Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/379538.

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Macrophage survival is believed to be a contributing factor in the development of early atherosclerotic lesions. Dysregulated apoptosis of macrophages is involved in the inflammatory process of atherogenesis. Apigenin is a flavonoid that possesses various clinically relevant properties such as anti-inflammatory, antiplatelet, and antitumor activities. Here we showed that apigenin attenuated atherogenesis inapoE-/-mice in anin vivotest.In vitroexperiments suggested that apigenin induced apoptosis of oxidized low density lipoprotein- (OxLDL-) loaded murine peritoneal macrophages (MPMs). Proteomi

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Wang, Bingyuan, Mingrui Zhang, Jiankang Guo, et al. "The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway." International Journal of Molecular Sciences 22, no. 22 (2021): 12209. http://dx.doi.org/10.3390/ijms222212209.

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Apigenin, a common dietary flavonoid abundantly present in a variety of fruits and vegetables, has promising anticancer properties. As an effector of apigenin in myoblasts, protein arginine methyltransferase 7 (Prmt7) is required for male germ cell development. However, whether apigenin may influence male reproductive health through Prmt7 is still unclear. To this end, mouse spermatogonia were treated with different concentrations (2.5 to 50 μM) of apigenin for 48 h, which showed that apigenin could cause reduced cell proliferation in conjunction with longer S phase and G2/M phase (with concen

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Ju, Sung Min, Jun Gue Kang, Jun Sang Bae, Hyun Ock Pae, Yeoung Su Lyu, and Byung Hun Jeon. "The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/186436.

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Apigenin is a member of the flavone subclass of flavonoids present in fruits and vegetables. Apigenin has long been considered to have various biological activities, such as antioxidant, anti-inflammatory, and antitumorigenic properties, in various cell types. Cisplatin was known to exhibit cytotoxic effect to renal cells by inducing apoptosis through activation of p53. The present study investigated the antiapoptotic effects of apigenin on the cisplatin-treated human renal proximal tubular epithelial (HK-2) cells. HK-2 cells were pretreated with apigenin (5, 10, 20 μM) for 1 h and then treate

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Lusiana Aprillia, Fendy Prasetyawan, Yuneka Saristiana, Ratna Mildawati, Chandra Arifin, and Abd Rofiq. "Pharmacokinetic Prediction Of Apigenin From Celer (Apium Graveolens L.) Using Pkcsm." Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan 1, no. 1 (2025): 16–24. https://doi.org/10.71417/galen.v1i1.3.

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Celery (Apium graveolensL.) is a plant that has various pharmacological activities. One of the main bioactive compounds in celery is apigenin. Understanding the pharmacokinetic properties of apigenin is very important in evaluating its effectiveness and safety as a drug candidate. This study aims to predict the pharmacokinetic properties of apigenin using the pkCSM computational approach. The prediction results show that apigenin has good intestinal absorption, but low water solubility. Distribution ability is moderate, with limited penetration into the central nervous system. Apigenin is not

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Liu, Limei, Dongdong Wei, Hongkun Xu, and Changhui Liu. "Apigenin ameliorates ocular surface lesions in a rat model of dry eye disease." European Journal of Inflammation 17 (January 2019): 205873921881868. http://dx.doi.org/10.1177/2058739218818681.

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To study the effects of apigenin on dry eye disease (DED) in rats. Rats were divided into six groups: (I) normal control group, (II) DED control group, (III) vehicle control group, (IV) DED + apigenin 10 mg/kg, (V) DED + apigenin 20 mg/kg, and (VI) DED + apigenin 50 mg/kg. Schirmer test, tear film break-up time (BUT), and corneal fluorescein staining were used to evaluate the effects of apigenin on the ocular surface. The related inflammatory cytokines were detected by enzyme-linked immunosorbent assay (ELISA). Histopathological examination and inflammatory index were also performed. The resul

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Li, Jie, Bingyong Mao, Xin Tang та ін. "Protective Effects of Naringenin and Apigenin in Ameliorating Skin Damage via Mediating the Nrf2 and NF-κB Pathways in Mice". Foods 12, № 11 (2023): 2120. http://dx.doi.org/10.3390/foods12112120.

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Naringenin and apigenin are common flavonoids derived from edible plants with the potential to alleviate inflammation and improve skin antioxidation. This study aimed to evaluate the effects of naringenin and apigenin on oleic acid-induced skin damage in mice and compare their underlying mechanisms of action. Triglycerides and non-esterified fatty acids were significantly decreased by naringenin and apigenin, while apigenin intervention resulted in a better recovery of skin lesions. Naringenin and apigenin improved the antioxidative abilities of the skin by increasing catalase and total antiox

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Kaewmanee, Mayurachat, Temduang Limpaiboon, and Nipaporn Ngernyuang. "Apigenin Induces Apoptosis and Inhibits Migration in Human Cholangiocarcinoma Cells." Toxics 13, no. 2 (2025): 112. https://doi.org/10.3390/toxics13020112.

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Cholangiocarcinoma (CCA) is a rare and highly aggressive cancer of the biliary tract, associated with poor clinical outcomes due to late diagnosis, extensive metastasis, drug resistance, and limited treatment options. Apigenin, a natural flavonoid, has been found to exhibit anticancer properties in several types of human cancer cells. Therefore, apigenin may be relevant to developing chemotherapeutic agents for cancer treatment. In this study, we examined the effects of apigenin on cell viability, cell cycle distribution, apoptosis, and cell migration in human CCA cell lines (KKU-M055) under i

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Farkas, Orsolya, Orsolya Palócz, Erzsébet Pászti-Gere, and Péter Gálfi. "Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/673847.

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Thein vitroanti-inflammatory effect of apigenin and its trimethylated analogue (apigenin-trimethylether) has been investigated in order to evaluate whether these flavonoids could attenuate LPS-induced inflammation in IPEC-J2 non-transformed intestinal epithelial cells. Levels of IL-6, IL-8, TNF-α, and COX-2 mRNA were measured as a marker of inflammatory response. The extracellular H2O2level in IPEC-J2 cells was also monitored by Amplex Red assay. Our data revealed that both compounds had significant lowering effect on the inflammatory response. Apigenin (at 25 μM) significantly decreased gene

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Saima, Saima, Irfan Anjum, Aisha Mobashar та ін. "Spasmolytic and Uroprotective Effects of Apigenin by Downregulation of TGF-β and iNOS Pathways and Upregulation of Antioxidant Mechanisms: In Vitro and In Silico Analysis". Pharmaceuticals 16, № 6 (2023): 811. http://dx.doi.org/10.3390/ph16060811.

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Apigenin is a phytochemical obtained from Chamomilla recutita. Its role in interstitial cystitis is not yet known. The present study is aimed at understanding the uroprotective and spasmolytic effects of apigenin in cyclophosphamide-induced interstitial cystitis. The uroprotective role of apigenin was analyzed by qRT-PCR, macroscopic analysis, Evans blue dye leakage, histological evaluation, and molecular docking. The spasmolytic response was measured by adding cumulative concentrations of apigenin to isolated bladder tissue pre-contracted with KCl (80 mM) and carbachol (10−9–10−4) on non-incu

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Ji, Jie, Qiang Yu, Weiqi Dai та ін. "Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways". PPAR Research 2021 (28 січня 2021): 1–15. http://dx.doi.org/10.1155/2021/6651839.

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Objective. The aim of this study is to confirm the hepatocellular protective functions of apigenin and the molecular mechanism on liver fibrosis in mice. Methods. Carbon tetrachloride (CCl4) and bile duct ligature (BDL) mouse fibrosis models were used to investigate the effects of apigenin on liver fibrosis. Sixty-six male C57 mice were randomly divided into eight groups, including the vehicle group, CCl4 group, CCl4+L-apigenin (20 mg/kg) group, CCl4+H-apigenin (40 mg/kg) group, sham group, BDL group, BDL+L-apigenin(20 mg/kg) group, and BDL+H-apigenin(40 mg/kg) group. Serum liver enzymes (ALT

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Zhao, Lin, Yuqiong Pei, Guoxin Zhang, et al. "Efficient Synthesis and In Vitro Hypoglycemic Activity of Rare Apigenin Glycosylation Derivatives." Molecules 28, no. 2 (2023): 533. http://dx.doi.org/10.3390/molecules28020533.

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Apigenin is a natural flavonoid with significant biological activity, but poor solubility in water and low bioavailability limits its use in the food and pharmaceutical industries. In this paper, apigenin-7-O-β-(6″-O)-d-glucoside (AG) and apigenin-7-O-β-(6″-O-succinyl)-d-glucoside (SAG), rare apigenin glycosyl and succinyl derivatives formed by the organic solvent-tolerant bacteria Bacillus licheniformis WNJ02 were used in a 10.0% DMSO (v/v) system. The water solubility of SAG was 174 times that of apigenin, which solved the application problem. In the biotransformation reaction, the conversio

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Zhang, Erkang, Yani Zhang, Zhuoyan Fan, Lei Cheng, Shiwen Han, and Huilian Che. "Apigenin Inhibits Histamine-Induced Cervical Cancer Tumor Growth by Regulating Estrogen Receptor Expression." Molecules 25, no. 8 (2020): 1960. http://dx.doi.org/10.3390/molecules25081960.

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Apigenin is a natural flavone with anti-inflammatory and antioxidant properties and antitumor abilities against several types of cancers. Previous studies have found that the antitumor effects of apigenin may be due to its similar chemical structure to 17β-estradiol (E2), a main kind of estrogen in women. However, the precise mechanism underlying the antitumor effects of apigenin in cervical cancer remains unknown. On the other hand, there is increasing evidence that describes a histamine role in cancer cell proliferation. In this study, we examined whether apigenin can attenuate the effects o

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Kim, Yeojin, Jihyun Kim, Meitong He, Ahyoung Lee, and Eunju Cho. "Apigenin Ameliorates Scopolamine-Induced Cognitive Dysfunction and Neuronal Damage in Mice." Molecules 26, no. 17 (2021): 5192. http://dx.doi.org/10.3390/molecules26175192.

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We investigated the protective effect and mechanisms of apigenin against cognitive impairments in a scopolamine-injected mouse model. Our results showed that intraperitoneal (i.p.) injection of scopolamine leads to learning and memory dysfunction, whereas the administration of apigenin (synthetic compound, 100 and 200 mg/kg/day) improved cognitive ability, which was confirmed by behavioral tests such as the T-maze test, novel objective recognition test, and Morris water maze test in mice. In addition, scopolamine-induced lipid peroxidation in the brain was attenuated by administration of apige

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Xu, Xinrong, Min Li, Weiwei Chen, Haitao Yu, Yan Yang, and Li Hang. "Apigenin Attenuates Oxidative Injury in ARPE-19 Cells thorough Activation of Nrf2 Pathway." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/4378461.

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The current study was aimed at evaluating the therapeutic implication of apigenin and to elucidate the underlying mechanism. Thetert-butyl hydroperoxide (t-BHP) at 200 μM was used to induce oxidative stress-associated injury in ARPE-19 cells. Apigenin at concentrations less than 800 μM did not cause cytotoxic effects on ARPE-19 cells. Cell viability assay showed that apigenin at 200 μM significantly promoted cell survival int-BHP-treated ARPE-19 cells. Additionally, apigenin at 100 μM significantly protected ARPE-19 cells fromt-BHP-induced apoptosis. Molecular examinations demonstrated that ap

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Angelica, Neffa Syavella, and Dominikus Raditya Atmaka. "Studi Literatur: Efektivitas Fitokimia Apigenin dalam Penurunan Tekanan Darah." Media Gizi Kesmas 14, no. 1 (2025): 156–64. https://doi.org/10.20473/mgk.v14i1.2025.156-164.

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Latar Belakang : Tekanan darah tinggi atau hipertensi termasuk penyakit tidak menular, namun penyakit tersebut merupakan salah satu penyebab utama kematian di dunia. WHO (World Health Organization) tahun 2023 menyatakan bahwa orang dewasa yang menderita hipertensi sebesar 46% dan sebagian besar tidak menyadarinya. Salah satu penanganan hipertensi adalah dengan menggunakan non-farmakologi yakni flavonoid jenis apigenin. Apigenin memiliki aktivitas antioksidanm anti-inflamasi, dan anti-apoptosis. Tujuan : Penelitian ini bertujuan untuk mengkaji bagaimana efektivitas apigenin terhadap penurunan t

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Ünal, Ali, Özge Göktepe, Melisa Çetinkaya, and Yusuf Baran. "Determination of the therapeutic effects of apigenin on chronic myeloid leukemia stem cells; a mechanistic approach." Journal of Current Hematology & Oncology Research 2, no. 2 (2024): 24–27. http://dx.doi.org/10.51271/jchor-0032.

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Aims: Chronic myeloid leukemia (CML) is a type of leukemia characterized by the Philadelphia (Ph) chromosome encoding the BCR-ABL protein. Significant success has been achieved in the treatment of CML with the development of agents that target this protein and inhibit its activity, but the resistance that develops in patients against these drugs limits absolute success. One of the main reasons for the resistance problem is the ineffectiveness of current therapies for CML stem cells. Apigenin (4',5,7- trihydroxyflavone) is a flavanoid found in various vegetables and fruits and has the effects o

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Kim, Hyun Ju, and Mok-Ryeon Ahn. "Apigenin Suppresses Angiogenesis by Inhibiting Tube Formation and Inducing Apoptosis." Natural Product Communications 11, no. 10 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101005.

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Apigenin has been reported to exert angiogenic and anticancer activities in vitro. The mechanism of inhibition of angiogenesis by apigenin, however, has not been well-established. In this study, we investigated whether apigenin not only inhibited tube formation but also induced apoptosis in human umbilical vein endothelial cells (HUVECs). Furthermore, strong antiangiogenic activity of apigenin was observed in the in vivo assay using chick embryo chorioallantoic membrane (CAM). We also analyzed changes in survival signals and the apoptotic pathway through Western blotting. The results indicate

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Suvarna, Vasanti, Shrutee Pawar, and Janavi Sosa. "Analytical Methods for Determination of Apigenin - An Update." International Journal of Health Sciences and Research 14, no. 8 (2024): 174–207. http://dx.doi.org/10.52403/ijhsr.20240825.

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Apigenin is a flavone abundantly present in various plants such as cherries, broccoli, legumes, parsley, and chamomile. In present article different analytical methods reported in various scientific studies for quantification and detection of apigenin in different formulations are presented. Various databases such as Science Direct, Pubmed Medical Subject Headings and Google scholar were used to retrieve the journal articles. Reported analytical methods for apigenin includes HPLC, UHPLC, HPTLC, TLC, GC, and capillary electrophoresis with MS, UV, PDA, and DAD detection. HPLC- MS was found to be

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Li, Ningning, Zhan Wang, Tao Sun, Yanfei Lei, Xianghua Liu, and Zhenzhen Li. "Apigenin Alleviates Renal Fibroblast Activation through AMPK and ERK Signaling Pathways In Vitro." Current Pharmaceutical Biotechnology 21, no. 11 (2020): 1107–18. http://dx.doi.org/10.2174/1389201021666200320140908.

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Objective: Renal fibrosis is a common pathway leading to the progression of chronic kidney disease. Activated fibroblasts contribute remarkably to the development of renal fibrosis. Although apigenin has been demonstrated to play a protective role from fibrotic diseases, its pharmacological effect on renal fibroblast activation remains largely unknown. Materials and Methods: Here, we examined the functional role of apigenin in the activation of renal fibroblasts response to transforming growth factor (TGF)-β1 and its potential mechanisms. Cultured renal fibroblasts (NRK-49F) were exposed to ap

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Shi, Yihua, Kai Lian, and Jiguang Jia. "Apigenin Suppresses the Warburg Effect and Stem-like Properties in SOSP-9607 Cells by Inactivating the PI3K/Akt/mTOR Signaling Pathway." Evidence-Based Complementary and Alternative Medicine 2022 (March 9, 2022): 1–10. http://dx.doi.org/10.1155/2022/3983637.

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Osteosarcoma (OS) is a prevalent primary malignant bone tumor that commonly occurs in children and adolescents. Apigenin (4′,5,7-trihydroxyflavone) is one of the most researched phenolic compounds that exhibits antitumor effects in several cancers. The aim of the current study was to investigate the effect and underlying mechanisms of apigenin on OS. To address this, OS cells (SOSP-9607) were treated with different concentrations of apigenin. The proliferation, migration, invasion, stem-like properties, and Warburg effect of apigenin-treated OS cells were evaluated. Apigenin was found to suppr

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Fossatelli, Laura, Zaira Maroccia, Carla Fiorentini, and Massimo Bonucci. "Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction." International Journal of Molecular Sciences 25, no. 1 (2023): 251. http://dx.doi.org/10.3390/ijms25010251.

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Apigenin is one of the most widespread flavonoids in the plant kingdom. For centuries, apigenin-containing plant preparations have been used in traditional medicines to treat diseases that have an inflammatory and/or degenerative component. In the 1980s, apigenin was proposed to interfere with the process of carcinogenesis. Since then, more and more evidence has demonstrated its anticancer efficacy, both in vitro and in vivo. Apigenin has been shown to target signaling pathways involved in the development and progression of cancer, such as PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, NF-κB, and Wnt/β-ca

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Shetti, P. P., S. Gudasi, and M. Kubade. "Apigenin in Apigenin Nanoliposomes: Development and Validation of an Analytical Technique Based on HPTLC." Research Journal of Biotechnology 20, no. 2 (2024): 13–19. https://doi.org/10.25303/202rjbt013019.

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Apigenin is a flavonoid found in various fruits and vegetables, aimed at its extensive array of biological actions such as anti-oxidant, anti-viral, antibacterial, anti-inflammatory, including chemo preventive property. Therefore, this study aimed to develop, describe and evaluate apigenin nanoliposomes. In this study, ethanol injection method was employed to formulate apigenin nanoliposomes. The quantification of apigenin in the nanoliposomes was carried out using a HPTLC analysis technique. The defined standards were followed in development and validation of the approach based on ICH guideli

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Wibawa, Teguh Hafiz Ambar, Eva Maria Widyasari, Iswahyudi Iswahyudi, et al. "PREPARASI SENYAWA ANTI KANKER APIGENIN BERTANDA RADIOIODIUM-131 UNTUK STUDI BIOAKTIVITAS." Jurnal Sains dan Teknologi Nuklir Indonesia 21, no. 1 (2020): 49. http://dx.doi.org/10.17146/jstni.2020.21.1.5788.

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PREPARASI SENYAWA ANTI KANKER APIGENIN BERTANDA RADIOIODIUM-131 UNTUK STUDI BIOAKTIVITAS. Apigenin merupakan senyawa flavonoid yang mempunyai potensi sebagai senyawa anti kanker, anti oksidan, dan anti inflamasi dengan toksisitas intrinsik yang rendah. Untuk mengetahui bioaktivitas apigenin, dapat dilakukan radioiodinasi kemudian dilanjutkan dengan studi praklinis menggunakan hewan uji. Pada penelitian ini dilakukan preparasi apigenin bertanda radioiodium-131 menggunakan metode kloramin-T dan optimasi berbagai parameter serta kondisi penandaan. Hasil optimasi diperoleh formula dan kondisi pena

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Liu, Danjie, Renjun Peng, Zhongmin Chen, et al. "The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury." Dose-Response 20, no. 3 (2022): 155932582211137. http://dx.doi.org/10.1177/15593258221113791.

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Radiation-induced intestinal injury (RIII) restricts the therapeutic efficacy of radiotherapy in abdominal or pelvic malignancies. Also, intestinal injury is a major cause of death following exposure to high doses of radiation in nuclear accidents. No safe and effective prophylactics or therapeutics for RIII are currently available. Here, we reported that the apigenin, a natural dietary flavone, prolonged the survival in c57 mice after lethal irradiation. Apigenin pretreatment brought about accelerated restoration of crypt-villus structure, including enhanced regenerated crypts, more different

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Shanaida, Mariia, Olesia Palamar, and Olena Holembiovska. "Chromatographic Profile of Polyphenols in the Agastache foeniculum (Pursh) Kuntze Herb: Evaluation of Optimal Extraction Efficiency." Biomedical and Pharmacology Journal 17, no. 1 (2024): 63–69. http://dx.doi.org/10.13005/bpj/2834.

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During its triple extraction, the HPLC analysis revealed polyphenols' contents in the A. foeniculum herb. Several hydroxycinnamic acids (rosmarinic, chlorogenic, ferulic and caffeic) and flavonoids (apigenin, apigenin-7-O-glucoside, hyperoside, quercitrin, rutin and quercetin) were identified in the A. foeniculum herb. It was established that rosmarinic acid followed by apigenin-7-O-glucoside and apigenin were the predominant compounds of the A. foeniculum raw material. The content of rosmarinic acid as the major compound during the primary, secondary and tertiary extraction decreased in the f

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Sharma, Ajay, Abdul Ghani, Katrin Sak, et al. "Probing into Therapeutic Anti-cancer Potential of Apigenin: Recent Trends and Future Directions." Recent Patents on Inflammation & Allergy Drug Discovery 13, no. 2 (2019): 124–33. http://dx.doi.org/10.2174/1872213x13666190816160240.

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Background: Natural products represent a therapeutic option for the treatment of inflammation- associated diseases. Flavonoids which are one of the special categories of such natural products, have previously shown promising therapeutic potential. Objectives: The current review discusses the synthetic preview and anti-inflammatory potential of apigenin along with the underlying molecular mechanism in chronic human diseases especially cancer. In addition, the relevant patents on the therapeutic potential of apigenin have also been mentioned. Methods: A literature search was carried out using Pu

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