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Journal articles on the topic 'And Cross carmellose sodium'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Nitalikar, Manoj M., and Dinesh M. Sakarkar. "Formulation development and characterization of fast disintegrating tablets of Nimesulide." Stamford Journal of Pharmaceutical Sciences 4, no. 2 (2012): 25–28. http://dx.doi.org/10.3329/sjps.v4i2.10436.

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An attempt was made to prepare fast dissolving tablets of anti-inflammatory drug Nimesulide preparing by direct compression method. The superdisintegrants Cross-carmellose and Sodium starch glycolate were used in different concentrations. Twelve formulations using those superdisintegrants at different concentration levels were prepared to access their efficiency and critical concentration level. Different evaluation parameters for tablet were studied. Tablets containing Cross-carmellose showed superior organoleptic properties and excellent in-vitro drug release as compared to other formulation

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2

K., Ramanji Reddy* Dr.Chandaka Madhu Dr. Mohammed Omar Sachin Vanji Ahirrao P.Jhansi Lakshmi. "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF FEXOFENADINE HYDROCHLORIDE." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3230–42. https://doi.org/10.5281/zenodo.967492.

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In the present work, mouth dissolving tablets of fexofenadine HCl were designed with a view to enhance patient compliance by direct compression method. The present work studied the effect of superdisintegrants on release rate of fexofenadine HCl in the form of fast disintegrating tablet. For the present study range of superdisintegrants in their different concentrations, were used. The superdisintegrants used were Magnesium stearate, Microcrystalline Cellulose, Cross Povidone, Sodium Starch Glycolate,and Cross Carmellose Sodium. The blends were prepared by direct compression technique. The tab

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3

Sepuri, Vijayalaxmi and N. Umasri. "FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF TENOFOVIR DISOPROXIL FUMARATE (TDF) IMMEDIATE RELEASE TABLETS." Indo Am. J. P. Sci, 2017 04, no. 05 (2017): 1229–41. https://doi.org/10.5281/zenodo.583712.

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In the present work, an attempt has been made to develop immediate release tablets of Tenofovir Disoproxil Fumarate (TDF). In the present work Sodium starch glycollate and Cross carmellose sodium were employed as super disintegrating agents for the selected drug molecule.. All the formulations were prepared by wet granulation method. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Am

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Ahmed, Shahriar, Mehrina Nazmi, Ikramul Hasan, Sabiha Sultana, Shimul Haldar, and Md Selim Reza. "Fexofenadine HCl Immediate Release Tablets: In vitro Characterization and Evaluation of Excipients." Bangladesh Pharmaceutical Journal 16, no. 1 (2013): 1–9. http://dx.doi.org/10.3329/bpj.v16i1.14483.

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Fexofenadine HCl immediate release tablets were designed to increase the dissolution rate by using superdisintegrants. Different formulations of Fexofenadine HCl were prepared by direct compression method. These formulations were evaluated for hardness, thickness, friability, weight variation, disintegration time, and in vitro dissolution study. The drug release from the formulations were studied according to USP specification (USP paddle method at 50 rpm for 60 minutes) maintaining the temperature to 37°C. Sodium starch glycolate, cross carmellose sodium, crospovidone (kollidon CL), ludiflash

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5

Ponnaganti, Hyma, and Kaveri Anke. "FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF ACECLOFENAC BY DIRECT COMPRESSION METHOD." Journal of Advanced Scientific Research 13, no. 02 (2022): 142–48. http://dx.doi.org/10.55218/jasr.202213219.

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Nowadays, Oro dispersible tablets are gaining much importance because it is easily approachable and due to its patient compliance. In this study, Formulation and evaluation of one such tablets of Aceclofenac by direct compression method using super disintegrants like Cross carmellose sodium (CCS) was performed. Due to low water soluble property of aceclofenac, it has poor dissolution and bioavailability. In order to minimize this property OTD’s are prepared. ODT’s were prepared by direct compression method using super disintegrant i.e Cross Carmellose Sodium (CCS) in different concentrat

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Mane, Swapna, Ritesh Bathe, and Sandhyarani Awatade. "Formulation and Evaluation of Fast Disintegrating Tablets of Atenolol Using Natural and Synthetic Superdisintegrants." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 150–58. http://dx.doi.org/10.22270/jddt.v9i2-s.2476.

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Oral disintegrating tablet (ODT) is defined as “A solid dosage form containing medical substances or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue”. The aim of the present research is to formulate Atenolol fast disintegrating tablets. Atenolol is β1- cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension, angina pectoris, arrhythmias and myocardial infarction. It works by slowing down the heart and reducing the work load of the heart. The conventional tablets of atenolol are reported to exhibit f

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7

Kadu, B. M., S. Bhasme, R. D. Bawankar, and D. R. Mundhada. "Formulation and Evaluation of Rapimelt Tablet of Anti-Vertigo Drug (Lorazepam)." International Journal of PharmTech Research 13, no. 4 (2020): 341–49. http://dx.doi.org/10.20902/ijptr.2019.130405.

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A. Rapimelt tablet of Lorazepam was prepared by direct compression method using Indion 414, Cross Carmellose Sodium and sodium starch glycolate as superdisintegrants with aim to get rapid onset of action, improve bioavailability and to give pleasant taste and better mouth feel. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and invitro dissolution time and were found to be within limits as per Indian Pharmacopoeia. FT-IR spectra of physical mixture of Lorazepam with Indion 414showedr

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8

Purkayastha, Hrishav Das, and Bipul Nath. "FORMULATION AND EVALUATION OF ORAL FAST DISINTEGRATING TABLET OF IBUPROFEN USING TWO SUPER DISINTEGRANTS." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 92. http://dx.doi.org/10.22159/20966.

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Objective: The aim of the present investigation was to design and evaluate orally disintegrating tablet (ODT) of Ibuprofen, a NSAID drug used for the treatment of arthritis with a view to improve its oral bioavailability. The focus of the current study was to develop ODT of Ibuprofen using super disintegrants for ease of administration and its physicochemical characterization.Methods: Tablets were made from blends by direct compression method. All the ingredients were passed through mesh no. 80. All the ingredients were co-ground in a pestle motor. The resulting blend was lubricated with magne

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9

Prasad, Garrepally. "Formulation and In Vitro Evaluation of Fast Dissolving Tablets for Albendazole." Journal of Clinical and Medical Case Reports and Reviews 1, no. 1 (2021): 1–3. http://dx.doi.org/10.59468/2837-469x/003.

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The present work is to study the effect of various superdisintegrants on drug (Albendazole) by direct compression methods. The tablets were prepared by four super disintegrants, e.g; sodium starch glycolate, cross carmellose, cross povidone and L- subsituated hydroxyl propyl cellulose. The blend was examined for angle of repose, bulk density, tapped density, compressibility index, and hausner ratio. The tablets were evaluated for hardness, drug content and friability were found satisfactory. Albendazole is a bitter in taste. To prevent bitter taste of the drug formulated with a sweetener (Aspa

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10

Prapti, J. Gawand1* Aashish Gorat2 Swara Gawand 3. Jyoti Gorad4 Vinay Ghumare5 Gangotri Yadav6 Ashish S. Jain7. "Design And Characterization Of Nutraceutical Antioxidant Oral Granules." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 875–82. https://doi.org/10.5281/zenodo.13941949.

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Granulation, or the agglomeration process that enlarges  patches, is one of the most important unit processes in the manufacturing of pharmaceutical lozenge forms, which are  substantially tablets and capsules. The purpose of this study was to develop and  estimate a nutraceutical formulation.The  granules were made using the wet granulation  system, with the active medicinal  element being an ethanolic excerpt of Lodhra( Symplocos racemosa) combined with sodium glycolate and cross carmellose sodium as disintegrants. The  grains were  estimated grounded

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11

Raghavender, Chenna 1. *. Y. Padmanabha Reddy 2. "FORMULATION AND EVALUATION OF CHRONOMODULATED DRUG DELIVERY OF NIMODIPINE." Journal of Pharma Research 7, no. 12 (2018): 305–13. https://doi.org/10.5281/zenodo.2616666.

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<strong><em>ABSTRACT</em></strong>   <strong><em>T</em></strong><em>he objective of this study was to design and developed a rupturable coating type of pulsatile press coated tablet, which releases drug early in the morning hours. This delivery system was helpful to control an early morning surge in Blood Pressure because cardiovascular events occur more frequently in the morning. This delivery system would be useful for the prevention of cardiovascular events in hypertensive patients. Initially core tablet was prepared by using Nimodipine as a drug, and different concentration of cross c

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12

Sunand, K., V. Sandhya, A. Swapna, K. Prasanth, A. Vijaya, and J. Geetha. "Formulation Design and in Vitro Evaluation of Oral Disintegrating Tablets of Selegiline." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 2, no. 04 (2017): 107–13. http://dx.doi.org/10.21477/ijapsr.v2i04.9603.

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In the present work, an attempt has been made to develop fast disintegrating tablets of Selegiline, were as sodium starch glycolate, cross povidone and cross carmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of drug molecule. Formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density and tapped density. The prepared tablets have shown good post compression parameters and they pas

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13

Lakshmi, P. K., D. Lavanya, and M. M. Husnien Ali. "Effect of synthetic super disintegrants and natural polymers in the preparation of donepezil hydrochloride fast disintegration films." International Current Pharmaceutical Journal 3, no. 3 (2014): 243–46. http://dx.doi.org/10.3329/icpj.v3i3.17892.

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The main aim of the present research was to develop a fast dissolving oral polymeric film with good mechanical properties, faster disintegration and dissolution when placed on tongue. Donepezil hydrochloride (DPH) is prescribed in the treatment of mild to moderate Alzheimers disease (AD). The polymers selected for preparing films were sodium alginate (SA), poly vinyl alcohol (PVA) and guar gum (GG). Three batches of films were prepared by solvent casting method with sodium alginate, sodium alginate & PVA and with the combination of sodium alginate & guar gum. From these three batches,

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14

Shahidulla, SM, and Tayyaba Jeelani. "Formulation and In-Vitro Evaluation of Taste Masked Fast Disintegrating Tablets of Labetalol Hydrochloride by Wet Granulation Technique." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 442–49. http://dx.doi.org/10.22270/jddt.v9i4-a.3506.

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Labetalol Hydrochloride is a β-blocker generally indicated for the treatment of hypertension, and it is extensively metabolized due to the hepatic metabolism. In the present work, an attempt was made to mask the taste by Solid Dispersion technique, with a formulation into Fast Disintegrating dosage form, using superdisintegrants such as Cross carmellose sodium (CCS), crospovidone (CP) and sodium starch glycolate (SSG). The complexes of Labetalol hydrochloride with HP-β-CD (1:3 ratio) were prepared by Co-precipitation method. Using the drug HP-β-CD complex, Fast Disintegrating tablets were prep

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15

Sharma, Mahavir K., Rupa Singh, Tejas K. Patel, Bhavik Jani, and Dhairyashri Kher. "Formulation and Evaluation of Mouth Dissolving Tablet of Biperiden HCL for Treatments of Parkinson’s Disease." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1533–37. http://dx.doi.org/10.25258/ijddt.13.4.63.

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Seven formulations were developed using superdisintegrating substances like sodium starch glycolate, crospovidone, and cross-carmellose sodium at different concentrations. Three batches were created by employing varying concentrations of the super disintegration approach, utilizing sodium starch glycolate as the superdisintegrating agent. The batches underwent evaluation regarding sensory characteristics, firmness, breakability, weight consistency, disintegration time in a simulated environment, time is taken for wetting, laboratory tests on drug release within a controlled environment, and as

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16

Yadav, Somdutt, Naresh Kalra, and Pankaj Arora. "Formulation and Optimization of Fast Dissolving Tablets of Zidovudine." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1393–400. http://dx.doi.org/10.25258/ijpqa.15.3.47.

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Fast-dissolving tablets (FDTs) have emerged as a prominent alternative to conventional oral dosage forms, particularly for drugs requiring rapid onset of action. This study aims to formulate and optimize fast-dissolving tablets of zidovudine, an antiretroviral medication used in the treatment of HIV/AIDS. The primary objective was to enhance patient compliance by ensuring the tablet disintegrates and dissolves quickly in the oral cavity without the need for water. Using various superdisintegrants like sodium starch glycolate and cross-carmellose sodium into, multiple formulations were prepared

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17

Nandi, U., M. Dahiya, A. Prakash, R. Kumar, and G. N. Singh. "COMPATIBILITY STUDY OF ALOGLIPTIN BENZOATE WITH WIDELY USED PHARMACEUTICAL EXCIPIENTS FOR SOLID DOSAGE FORM." INDIAN DRUGS 55, no. 02 (2018): 20–26. http://dx.doi.org/10.53879/id.55.02.10907.

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Alogliptin is a new dipeptidyl peptidase-4 (DPP-4) inhibitor for oral diabetes care. The present study aims to evaluate the compatibility of alogliptin benzoate with the extensively used pharmaceutical excipients for solid dosage form. This can be achieved by applying Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA) techniques together with Fourier-Transform Infrared spectroscopy (FT-IR) as paired technique to aid in the interpretation of outcome. Chosen excipients were Cross carmellose sodium, microcrystalline cellulose, magnesium stearate, sodium starch glycolat

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C., Haranath* T. Srikanth M. Suresh Krishna G. Chaithanya Barghav C. Mahesh Reddy. "FORMULATION AND INVITRO EVALUATION OF FAST DISINTEGRATING TABLETS OF AN ANTI-INFLAMMATORY DRUG." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 10790–99. https://doi.org/10.5281/zenodo.3229226.

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<em>Oral disintegrating tablets are defined as the tablets that disperse or disintegrates in less than one minute in the mouth prior to being swallowed, which results in the rapid dissolution and absorption of the active pharmaceutical ingredient contained in the tablet, providing rapid onset of action. Aceclofenac is a poorly water-soluble drug. The solubility of the drug was enhanced by solid dispersion technique using mannitol as the carrier. In the present study, 9 formulations were developed by using different super disintegrants like cross povidone, sodium starchglycolate and cross carme

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Narasaiah, V. L., Ch Praneetha, P. Mallika, K. Pullamma, S. Shilpa, and P. V. V. Ramakrishna. "DESIGN AND CHARACTERIZATION OF ACECLOFENAC FAST DISSOLVING TABLETS USING SUPER DISINTEGRATING AGENTS." INDIAN DRUGS 51, no. 01 (2014): 34–40. http://dx.doi.org/10.53879/id.51.01.p0034.

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The aim of this project was to develop fast dissolving tablets (FDT) of aceclofenac by wet granulation using super disintegrating agents such as cross carmellose sodium (CCS), Crospovidone (CP) and sodium starch glycolate (SSG) were formulated and evaluated. The tablets evaluated for thickness, hardness, friability weight variation, drug content, water absorption ratio, wetting time, disintegration time and in vitro dissolution studies. The in vitro release studies were conducted in pH 7.4 phosphate buffer. Different release models like zero order, first order, Higuchi and Korsmeyer-Peppas wer

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Singh, Sudarshan, S. S. Shyale, and G. Bhosale. "Formulation and Evaluation of Mouth Dissolving Tablets of Piroxicam." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 3 (2015): 2941–46. http://dx.doi.org/10.37285/ijpsn.2015.8.3.8.

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Piroxicam, a non-steroidal anti-inflammatory agent, is widely used in rheumatoid arthritis, osteoarthritis, musculo-skeletal disorders, dysmenorrhoeal and post-operative pain. It has poor bioavailability due to its inherent properties. The objective of present study is to enhance water solubility of Piroxicam by solid dispersion technique and to develop novel method of preparing compressed tablets for Piroxicam with high porosity which dissolves rapidly in mouth, using camphor as sublimating agent and super disintegrants such as Crosscarmellose sodium and sodium starch glycollate. The tablets

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CHOURSIYA, ARTI, and DEEPIKA PANDIT. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LANSOPRAZOLE BY SOLUBILITY ENHANCEMENT TECHNIQUE." Current Research in Pharmaceutical Sciences 11, no. 2 (2021): 54–64. http://dx.doi.org/10.24092/crps.2021.110203.

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The present study was focused on preparation and evaluation of Lanzoprazole fast dissolving tablets. Lansoprazole (LAN) is a proton pump inhibitor drug and used for the treatment of gastric ulcer. Lansoprazole is acid labile drug and to avoid the acidic pH of the stomach LAN is formulated as oral fast dissolving tablets. Lansoprazole is the class II drug of the BCS classification and has a low aqueous solubility. Hence, to improve the solubility of the drug we have prepared Lansoprazole solid dispersion with poly ethylene glycol and complex with β cyclodextrin. Fast Dissolving tablets of LAN w

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Desu, Prasanna Kumar, Brahmaiah Bonthagarala, and Pasam Venkateswara Rao. "Formulation and evaluation of Nateglinide dispersible tablet by direct compression method." International Journal of Advances in Scientific Research 1, no. 1 (2015): 51. http://dx.doi.org/10.7439/ijasr.v1i1.1784.

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The study was carried to formulate and evaluate dispersible tablet dosage form obtaining Nateglinide.Nateglinideis adrugfor the treatment oftype 2 diabetes. The present study is an attempt to select best possible combination of diluents and disintegrates to formulate dispersible tablet of Nateglinide which disintegrates within few minutes thereby reducing the time of onset of action. Mannitol is selected as diluents, Sodium starch glycol ate, Cross-povidone, cross-carmellose sodium were selected as super disintegrates, citric acid and sodium bi carbonate is effervescent active ingredient in di

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Rao, Nagineni Sudarshan, Rama Rao Vadapalli, Brahmaiah Bonthagarala, Jalluri Charishma Vasavi, and Mallabathula Meghana. "Improving Solubility and Dissolution Characteristics of Dapoxetine Hydrochloride through the Liquisolid Compact Method." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–08. https://doi.org/10.25258/ijddt.15.2.7.

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This study aimed to enhance the solubility and dissolution properties of Dapoxetine hydrochloride (DXH) tablets by using of novel method i.e., liquisolid compact technology (LCT). A total of 9 formulations of DXH tablets were prepared by using carrier materials like microcrystalline cellulose and coating materials like lactose, silica, and starch. In out of nine formulations Super disintegrants like cross povidone (CP) in F1–F4 and Cross Carmellose Sodium in F5–F9 added. All formulations were evaluated for both pre compressional and post compressional evaluation parameters. Based on the evalua

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Avinash, B. Darekar, N. Jadhav Sonali, and B. Saudaga Ravindra. "Design Development and Evaluation of Bilayer Tablet Using Eprosartan Mesylate for the Treatment of Hypertension." International Journal of Current Pharmaceutical Review and Research 8, no. 4 (2017): 328–37. https://doi.org/10.5281/zenodo.12674990.

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The aim of present study is to formulate Eprosartan Mesylate sustained release (SR) and immediate release (IR) bilayertablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and HPMC K 100 M to control the releasepattern. The sustained release layer of Eprosartan Mesylate was prepared by using different grades of HPMC like, HPMCK-100, HPMC along with other excipients by direct compression technique. The immediate release layer of EprosartanMesylate was prepared by Cross carmellose sodium and Sodium starch glycolate by direct compression technique. Thepowders were evaluated fo

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Singh, Harmanpreet, Pooja Jaiswal, Suksham Gupta, and Simerjit Singh. "FORMULATION OF RIZATRIPTAN BENZOATE SUBLINGUAL TABLETS PREPARED BY DIRECT COMPRESSION WITH DIFFERENT BIOADHESIVE POLYMER: IN VITRO AND EX VIVO EVALUATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 16 (2017): 36. http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21334.

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Objective: The current investigation deals with formulation and evaluation of fast disintegrating sublingual tablets of rizatriptan benzoate (RTB) to produce its intended therapeutic effect for acute treatment of migraine. When the drug is given by sublingual route, it overcomes the first pass metabolism and quick entry of drug in systemic circulation is obtained. It would result in fast pharmacological response hence faster relief from migraine which is an important criterion in migraine therapy.Methods: In this study, RTB sublingual tablets were prepared using direct compression process usin

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Patil, Swapnil S., Rohan D. Patil, Prakash V. Chavan, et al. "OPTIMIZATION AND CHARACTERIZATION OF FAST DISSOLVING TABLETS OF CANDESARTAN CILEXETIL PREPARED FROM SPHERICAL AGGLOMERATES." INDIAN DRUGS 61, no. 01 (2024): 46–52. http://dx.doi.org/10.53879/id.61.01.13910.

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The primary objective of this study was to develop a rapidly dissolving tablet containing an antihypertensive drug, candesartan cilexetil (CAND). The research work focused on improving solubility and in vitro dissolution of drugs using spherical agglomeration technique. Spherical agglomerates of CAND were developed using PVPK-30 as polymer and dichloromethane as bridging liquid. A spherical agglomerate of CAND was used to formulate fast dissolving tablet (FDT) with different superdisintegrants like Crospovidone and Cross carmellose sodium. The prepared powder blend was evaluated for different

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K, Venkatesh, Ramu B, and Rajkamal B. "Formulation and Evaluation of Risperidone Fast Disintegrating Tablets by Using Co- processed Superdisintegrants." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 334–42. https://doi.org/10.5281/zenodo.13754623.

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In the present work, an attempt has been made to develop fast disintegrating tablets of Risperidone. Novel method of co processed super disintegrates technology was employed to formulate the tablets. All the formulations were prepared by direct compression method using 8mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the

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M., Anusha, Varun Raj S., Krishna Srewe P.V., Divya Deepthi N., Evanjiline Ch., and Roopa Koteswari Ch. "Formulation and Development of Rosuvastatin Fast Dissloving Tablets using Natural Super Disintegrates." Research & Review: Drugs and Drugs Development 1, no. 2 (2019): 61–77. https://doi.org/10.5281/zenodo.3271091.

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<em>Rosuvastatin is in category of the drug class. It is used to treat high cholesterol and to block cardiovascular disease. The main aim of this study is to develop oral dispersible tablets of Rosuvastatin using different types of super disintegrates to enhance the disintegration and dissolution of Rosuvastatin to improve bioavailability of the drug. Many trials were made to prepare a satisfactory rosuvastatin oral dispersible tablet using direct compression and wet granulation method. Formulate tablets were examine with different parameters such as weight variation, hardness, friability, wet

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Rayakwar, Neetesh, and Yuvraj Singh Dangi. "Development and characterization of controlled release bilayered tablets of Citicoline sodium." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 125–31. http://dx.doi.org/10.22270/jddt.v9i2-s.2471.

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Objectives: The aim of present investigation was formulation development and evaluation of bi-layer tablets of citicoline sodium. Materials and Methods: An aqueous granulation process was adopted to formulate citicoline sodium (CTS) bilayer tablets. Wet granulation method has been utilized for the formulation of bilayer CTS tablet. Citicoline sodium, microcrystalline cellulose (pH 101 & 102), HPMC K4, K15, K-100, PVP K-30, Magnesium stearate, cross-carmellose sodium, sodium starch glycolate and red oxide were used for preparation. Pre-formulation studies of citicoline sodium and drug excip

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B. H. Al-Khedairy, Eman. "Effect of Additives on the Solubility and Dissolution of Piroxicam From Prepared Hard Gelatin Capsule." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 1 (2017): 117–22. http://dx.doi.org/10.31351/vol21iss1pp117-122.

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Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of musculo-skeletal and joint disorders. The problem with this drug is its poor solubility in water and hence poor bioavailability after oral administration. In order to improve its solubility and dissolution behavior, hydrophilic additives such as starch, lactose, superdisintegrants including crospovidone (C.P), cross carmellose sodium (CCS), and sodium starch glycolate (SSG) were physically dry mixed with the drug by simple trituration. The improvement in the solubility in 0.1 N HCl was obtained as the amount o

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Sharma, R. B., V. Arora, S. Arora, A. Kapila, and R. Sharma. "The effect of biomaterials of cross carmellose sodium and Eudragit S-100 as model polymers on colon targeted drug release in different dosage forms." Materials Today: Proceedings 48 (2022): 1638–44. http://dx.doi.org/10.1016/j.matpr.2021.09.526.

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Siddheshwar, Suhas Shivaji, Asmita Bhausaheb Ghorpade, Someshwar Dattatraya Mankar, and Santosh Bhausaheb Dighe. "Formulation and Drug Release Study of Rivaroxaban Oral Disintegrating Tablets Using Various Super-Disintegrants." International Journal of Experimental Research and Review 36 (December 30, 2023): 147–55. http://dx.doi.org/10.52756/ijerr.2023.v36.014.

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This study aims to improve Rivaroxaban's solubility, dissolution, and bioavailability. Orally disintegrating tablets (ODTs) made with super-disintegrants like crospovidone, sodium starch glycolate, and cross-carmellose sodium will do this. Tablet preparation used direct compression and formulation optimization with design expert software. After a thorough factorial design and evaluation of pre- and post-compression parameters, the F3 batch, which contained Rivaroxaban (7.97%), Crospovidone (3.59%), Croscarmellose sodium (5.18%), Sodium Starch Glycolate (5.18%), Lactose Anhydrous (31.08%), Mann

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Anusha, B. H.*1 Nagendra R.2 Venkatesh3 Hanumanthachar Joshi K.4. "Formulation And Evaluation of Fast Disintegrating Tablet of Betaxolol Hydrochloride Using Super Disintegrants." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 362–76. https://doi.org/10.5281/zenodo.14050550.

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The study focused on developing a fast-disintegrating oral tablet of Betaxolol Hydrochloride aimed at treating hypertension through a direct compression method. Various formulations were tested using different concentrations of super disintegrants, with Microcrystalline cellulose serving as the diluent. Mannitol was utilized as a directly compressible diluent, while aspartame was chosen for its intense sweetness. Additionally, magnesium stearate and talc acted as lubricants, and aerosil was included to enhance flow properties. Pineapple flavor was added to improve the tablet's palatability. Th

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Kundawala, Aliasgar, Pratik Patel, Khushbu Chauhan, Anjali Desai, and Dhwani Kapadia. "Formulation and Optimization of Orodispersible Tablet of Loratadine Using Box Behnken Design." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 86–94. http://dx.doi.org/10.22270/jddt.v9i4-a.3402.

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In present study Orodispersible tablets (ORDT) of Loratadine were prepared and optimized. Solid dispersion of Loratadine- β cyclodextrin complex were prepared and used in preparation of Orodispersible tablets. Various super-disintegrating agent like Cross carmellose sodium, Cross povidone and Kyron T-314 were employed for faster disintegrating effect. The 24 factorial and Box-Behnken design were utilized to optimize the tablet formulation. The Orodispersible tablet of Loratadine was optimized by Box Behnken Design, where concentrations Kyron T-314, CRP and Pearlitol SD200 were employed and its

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Palival,, Sourabha, and Shailendra Kumar Modi. "Formulation and Evaluation of Metoclopramide Orodispersible Tablet." International Journal of Pharmaceutical Research and Applications 09, no. 05 (2024): 751–60. https://doi.org/10.35629/4494-0905751760.

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In the study all the formulation were subjected to physical parameters of tablets, like hardness, friability, weight variation, drug content of Metoclopramide hydrochloride. All the formulations resulted in acceptable limit except formulation MF3 and MF8 for hardness test marginally deviated. The final batch MF9 (contained Cross Carmellose Sodium 5.3%) can be considered as optimized batch as it has the disintegration time is minimum (26 sec) seems to be most promising formulation which gives the release up to 99.60% in 3min. The drug-excipients interaction studies were carried out by FTIR. No

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Arunkumar, Selvi, L. Srinivas, D. Satyavati, and C. Emmanuel. "Comparative Study of Antihypertensive Drugs Amlodipine Besylate /Metoprolol Succinate and Nebivolol Hydrochloride /Valsartan Combinations in Bilayer Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 529–39. http://dx.doi.org/10.22270/jddt.v9i4-s.3214.

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The present research is an approach to develop a formulation platform that shall help in minimizing the time and effort taken to develop a drug delivery system. Taking bilayer tablet technology as a representation for drug delivery system, well accepted antihypertensive drugs, Amlodipine besylate and Metoprolol succinate were considered as model drugs for the study. Initially the process variables like concentration of the disintegrants, Sodium starch Glycolate and cross carmellose sodium, Polymers HPMC K100M and K4M were standardized with these drugs so that the incorporation of a new combina

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Roy, Harekrishna, Sisir Nandi, Ungarala Pavani, Uppuluri Lakshmi, Tamma Saicharan Reddy, and Damarla Venkata Sri Gayatri. "Optimization and Quality by Design Approach for Piroxicam Fast Dissolving Tablet Formulations Using Box-Behnken Design." Current Drug Therapy 15, no. 2 (2020): 152–65. http://dx.doi.org/10.2174/1574885514666190409102614.

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Background: The present study deals with the formulation and optimization of piroxicam fast dissolving tablets and analyzes the impact of an independent variable while selecting the optimized formulation utilizing Quality by Design (QbD) and Box-Behnken Design (BBD). Methods: Seventeen formulations were prepared by direct compression technique by altering the proportion of cross carmellose sodium, spray dried lactose and hydro propyl methyl cellulose (HPMC K4M). The BBD statistical technique was used to optimize formulations and correlate the relationship among all the variables. Also, the pow

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Mohammad Gufran, Mohammad Faizan, Sailesh Kumar Ghatuary, Reena Shende, Prabhat Kumar Jain, and Geeta Parkhe. "Formulation, Development and Evaluation of Bilayer Floating Tablet of Gemfibrozil." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 574–78. http://dx.doi.org/10.22270/jddt.v9i4-s.3401.

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Formulation development is an important part of drug design and development. Bioavailability and bioequivalence are totally dependent on formulation development. Now-a-days formulation development is done by following QbD (Quality by Design).The aim of present study is to formulate Gemfibrozil (Gem) sustained release (SR) and immediate release (IR) bilayer tablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and HPMC K 100 M to control the release pattern. The sustained release layer of Gem was prepared by using different grades of HPMC like, HPMC K-15, HPMC K-4 along with

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Kamal, Kamal Kant, Ashutosh Sharma, Mayank Bansal, and Vishal Choudhary. "Design and evaluation of bi-layered tablet of Ramipril and hydrochlorothiazide for the Treatment of hypertension." Journal of Biomedical and Pharmaceutical Research 14, no. 3 (2025): 38–41. https://doi.org/10.32553/jbpr.v14i3.1320.

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Hypertension is a widespread cardiovascular disease that requires effective management through combination therapy. The complexity of hypertension necessitates a multifaceted approach, often involving the concurrent administration of multiple antihypertensive agents. This study aims to design, formulate, and evaluate bi-layered tablets of Ramipril and Hydrochlorothiazide, leveraging the benefits of sequential drug release and stability enhancement. The bi-layer tablet formulation comprises an immediate-release layer for rapid therapeutic onset and a sustained-release layer for prolonged plasma

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Pavlović, Nebojša, Isidora Anastasija Bogićević, Dragana Zaklan, et al. "Influence of Bile Acids in Hydrogel Pharmaceutical Formulations on Dissolution Rate and Permeation of Clindamycin Hydrochloride." Gels 8, no. 1 (2022): 35. http://dx.doi.org/10.3390/gels8010035.

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Clindamycin hydrochloride is a widely used antibiotic for topical use, but its main disadvantage is poor skin penetration. Therefore, new approaches in the development of clindamycin topical formulations are of great importance. We aimed to investigate the effects of the type of gelling agent (carbomer and sodium carmellose), and the type and concentration of bile acids as penetration enhancers (0.1% and 0.5% of cholic and deoxycholic acid), on clindamycin release rate and permeation in a cellulose membrane in vitro model. Eight clindamycin hydrogel formulations were prepared using a 23 full f

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Trofimiuk, Monika, Małgorzata Sznitowska, and Katarzyna Winnicka. "Oral Gels as an Alternative to Liquid Pediatric Suspensions Compounded from Commercial Tablets." Pharmaceutics 16, no. 9 (2024): 1229. http://dx.doi.org/10.3390/pharmaceutics16091229.

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The aim of the study was to propose pharmacy-compounded oral gels as a new and alternative dosage form that is attractive to children as having a better masking taste than syrups and reducing the risk of spilling. The application and physical properties of the gels prepared with cellulose derivatives (hydroxyethylcellulose and carmellose sodium) or carbomers were evaluated. The results of the study showed the most suitable consistency, viscosity, and organoleptic properties for gels prepared with carbomer and cellulose derivatives at concentrations of 0.75% and 2.0%, respectively. The microbia

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Kejdušová, Martina, Jakub Vysloužil, Kateřina Kubová, et al. "Antimicrobial Properties of Microparticles Based on Carmellose Cross-Linked by Cu2+Ions." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/790720.

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Carmellose (CMC) is frequently used due to its high biocompatibility, biodegradability, and low immunogenicity for development of site-specific or controlled release drug delivery systems. In this experimental work, CMC dispersions in two different concentrations (1% and 2%) cross-linked by copper (II) ions (0.5, 1, 1.5, or 2.0 M CuCl2) were used to prepare microspheres with antimicrobial activity againstEscherichia coliandCandida albicans, both frequently occurring pathogens which cause vaginal infections. The microparticles were prepared by an ionotropic gelation technique which offers the u

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KUWAMURA, Yuki, Shinji NITO, and Yoshiaki KAWAI. "Morphological Changes in Hepatic Ito Cells after Parenteral Treatment with Carmellose Sodium in Rats." Experimental Animals 46, no. 3 (1997): 191–95. http://dx.doi.org/10.1538/expanim.46.191.

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Gazikalovic, Emilija, Dusan Obrenovic, Zivorad Nidzovic, and Olivera Colic. "Manufacture of tetracaine hydrochloride lozenges preparation by direct compression and wet granulation methods." Vojnosanitetski pregled 59, no. 6 (2002): 621–24. http://dx.doi.org/10.2298/vsp0206621g.

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The results of quality testing of lozenges made by direct compression and by wet granulation procedure (Ph. Jug. IV) are presented. The aim was to determine hardness, friability and disintegration of the lozenges. Considering the fact that the produced tetracaine hydrochloride lozenges were not transported, but were made according to the needs of the Clinic of Gastroenterology, Military Medical Academy, time of disintegration, not hardness and friability, was the priority in making a choice of formulation. That is why tetracaine hydrochloride lozenges made with 3.5% solution of carmellose sodi

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B. Borse, Laxmikant, Atul R. Bendale, Sandhya L. Borse, Vaishali D. Naphade, and Anil G. Jadhav. "Formulation and Evaluation of Mouth Dissolving Tablet Rivaroxaban and its Validation." Biosciences Biotechnology Research Asia 19, no. 4 (2022): 943–54. http://dx.doi.org/10.13005/bbra/3043.

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ABSTRACT: The foremost intention of present research was the preparation and assessment of mouth dissolving formulation Rivaroxaban and its validation. During present work, this tablet was formulated by straight compression technique by means of Cros-carmellose sodium and Sodium starch glycolate as super-disintegrants (concentration of 2, 4, 6%) and Avicel 102 as a binder. The formulated preparations were exposed to different consideration parameters like hardness test, friability test, disintegration test, release of drug and content of drug. The calibration curve of API using solvent phospha

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Sánchez-González, José-María, Carmen Silva-Viguera, María Carmen Sánchez-González, et al. "Tear Film Stabilization and Symptom Improvement in Dry Eye Disease: The Role of Hyaluronic Acid and Trehalose Eyedrops versus Carmellose Sodium." Journal of Clinical Medicine 12, no. 20 (2023): 6647. http://dx.doi.org/10.3390/jcm12206647.

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This study evaluated the effectiveness of hyaluronic acid and trehalose (HA/trehalose) eyedrops in managing dry eye disease (DED) symptoms by measuring tear stability and administering a DED questionnaire. Sixty patients were treated with either HA/trehalose eyedrops (Tear A) or carmellose sodium eyedrops (Tear B) as controls. The tear breakup time (TBUT) and non-invasive breakup time (NIBUT) were monitored, and patients completed the standard patient evaluation of eye dryness (SPEED) questionnaire. After two months of twice-daily applications, patients treated with the HA/trehalose eyedrops d

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Volodymyr, Yakovenko, Orlenko Dmytro, and Vyshnevska Liliia. "Study of structural and mechanical properties of bases in the development of dental gel with combined composition." ScienceRise: Pharmaceutical Science, no. 5(21) (October 31, 2019): 35–41. https://doi.org/10.15587/2519-4852.2019.182398.

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<strong>Aim.</strong> The development of the composition of the dental gel for the treatment of infectious and inflammatory diseases of the oral cavity, taking into account the physicochemical properties of the active pharmaceutical ingredients, namely the justification of the type and concentration of the gelling agent and other excipients. <strong>Methods</strong>. The determination of organoleptic characteristics, uniformity of gel samples, pH of aqueous extract, and structural viscosity index was carried out according to the methods of the State Pharmacopoeia of Ukraine. Rheological s

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Birsan, Magdalena, Nela Bibire, Alina Diana Panainte, et al. "The Influence of the Preparation Method on the Characteristics of a New Cosmetic Gel Based on Hyaluronic Acid and Matrix-Forming Polymers." Materiale Plastice 57, no. 2 (2019): 123–30. http://dx.doi.org/10.37358/mp.20.2.5358.

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Because hyaluronic acid (HA) cosmetic gels are the most commonly used gels in the cosmetic industry, the purpose of this study was to develop a new gel formulation of HA in carboxymethyl cellulose sodium (Carmellose, CMC Na), prepared in three different ways and to characterize the gel obtained in terms of texture, pH, thixotropy and decide which preparation method is optimal for obtaining a cosmetic gel. The gel formulations were prepared by dispersing CMC Na in water and glycerol and mixing it in three different ways with HA (at the same time, after gelling and 24 h after gel preparation). T

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Di Palma, Cristina, Fabiana Micieli, Barbara Lamagna, et al. "Schirmer Tear Test Value and Corneal Lesions’ Incidence during General Anesthesia for Non-Ophthalmic Surgery in Non-Brachycephalic Dogs: A Pilot Study Comparing Three Different Lubricant Eye Drop Formulations." Veterinary Sciences 7, no. 1 (2020): 25. http://dx.doi.org/10.3390/vetsci7010025.

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Aim of this blinded, prospective, randomized clinical study was to compare three different lubricant eye drops (LED) in healthy adult dogs undergoing general anaesthesia (GA) for non-ophthalmic surgery. Tear production rate was monitored by means of Schirmer tear test-1 (STT-1), and incidence of post-operative corneal abrasions/ulcerations was detected by corneal staining. A complete ophthalmic examination was performed before premedication, at extubation time and 24 h after GA in twenty-five non-brachycephalic dogs (fifty eyes) undergoing elective orthopaedic or spinal surgery procedures. Dog

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Ashok Munde, Akanksha. "Artificial tears for dry eye: A review." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 592–602. https://doi.org/10.35629/4494-0906592602.

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Artificial tears are essential for managing dry eye disease, but they also aid in corneal abrasion and wound healing, managing pain and inflammation, treating conjunctivitis and keratitis, rewetting and removing contact lenses, and eliminating foreign bodies. A systematic review of randomized controlled trials (PROSPERO registration CRD42022369619) aimed at evaluating the effectiveness of artificial tears in individuals with dry eye to guide prescribing decisions, utilizing Web of Science, PubMed, and Medline databases, revealed 64 pertinent articles. There is strong evidence that artificial t

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