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Dissertations / Theses on the topic 'And drug formulations'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

Monteith, David. "Drug precipitation from injectable formulations." Thesis, University of Strathclyde, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428061.

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2

Santos, Paulo Antonio Fernandes Gomes. "Transdermal drug delivery using spray formulations." Thesis, University College London (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497653.

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3

Christy, R. K. "The physical chemistry of drug formulations." Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362185.

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4

Tandya, Andrian Chemical Sciences &amp Engineering Faculty of Engineering UNSW. "Dense gas particle processing for alternative drug delivery formulations." Awarded by:University of New South Wales. School of Chemical Sciences and Engineering, 2006. http://handle.unsw.edu.au/1959.4/25480.

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Pulmonary and oral drug administrations are usually the preferred methods of delivery of active pharmaceutical ingredients.Generally,pulmonary drug formulations are more attractive compared to oral formulations since they consist of micron-sized powders with high surface area thus having faster onset of action,as well as minimizing the drug dosage and side effects.Oral insulin formulations,if achievable,would provide an alternative to injectable insulin,as the common drawbacks of injectable insulin are the multiple daily injections and the possibility of skin infections at the injection site.

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5

Shehab, M. A. "Drug release from liquid filled capsule formulations." Thesis, De Montfort University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373432.

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6

Henriques, Neves Vieira R. I. "Volatile formulations for (trans) dermal drug delivery." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1393591/.

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Overcoming the excellent barrier properties of the human skin represents the major challenge of this route of delivery. The Metered dose transdermal spray (MDTS®) is a technology developed by Acrux Ltd (AUS). This passive delivery system has the potential to avoid skin irritation. An informed choice of solvents is one of the strategies to design efficient transdermal formulations. Therefore, it is the aim of this thesis to develop optimal volatile formulations and to investigate the enhancement effects of solvents on drug permeation through the skin. A secondary objective is to evaluate the in

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7

Paulsson, Mattias. "Controlled Release Gel Formulations for Mucosal Drug Delivery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5173-X/.

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8

Subramanian, Sneha. "Proliposome and prosurfactosome formulations for pulmonary drug delivery." Thesis, University of Central Lancashire, 2015. http://clok.uclan.ac.uk/16722/.

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This study aims to compare the efficiency of conventional liposomes and surfactant-enriched vesicles (surfactosomes) using the hydrophilic drug salbutamol sulphate (SBS) and the hydrophobic drug beclometasone dipropionate (BDP) for pulmonary delivery via nebulisation. Initially liposomes and surfactosomes with or without cholesterol were prepared using thin film method and were compared for their VMD, span and drug entrapment. Their drug retention on extrusion through 5µm, 2µm, 1µm and 0.4µm polycarbonate membrane using mini-extruder was also studied. It was observed that liposomes were more s

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9

Sutch, Jonathan C. D. "Optimising Microenvironmental pH and Drug Release from Formulations Containing a Weakly Basic Drug." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489694.

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The release ofpapaverine, a weakly basic drug, is pH dependent. To allow drug release throughout the changing pH milieu ofthe gastrointestinal tract, weak acid modifiers are often added to modify the microenvironmental pH. A technique to measure the microenvironmental pH by confocal microscopy (CLSMpH) has been optimised to allow accurate measurement in coated pellets. A central composite design was used to investigate the effect of formulation factors on drug release and CLSMpHÃ‚Â• Acid modifiers and fillers of varying solubility were also investigated. The solubility and proportion ofthe aci

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10

Marshall, D. J. "The use of accelerants in topical formulations." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234278.

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11

Wagner, Daniel. "Sustained release formulations for compounds underlying intestinal drug efflux." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=96927890X.

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12

Ng, Anna. "Taste-masked and controlled-release formulations of chloroquine." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267929.

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13

Ur-Rehman, Tofeeq. "Controlled release gel formulations and preclinical screening of drug candidates." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40489.

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Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. In particular co-solvents (DMSO, ethanol), mucoadhesive polymers (chitosan, alginate) and salts (sodium tripolyphosphate, CaCl2) have been used to enhance the applications of poloxamer 407 (P407) formulations in preclinical animal studies. The impact of these additives on the micellization and

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14

Abdalghafor, H. M. "Mechanistic studies on topical drug delivery from liquid crystal formulations." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1426962/.

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The primary objective of this research was to investigate the possible effects of selected liquid crystal (LC) forming surfactants, namely ArlacelTM 2121, CrodafosTM CES and BrijTM system (BrijTM S721/ BrijTM S2) and selected oils, namely, Arlamol™ PS15E, Crodamol™ OP, Arlamol™ HD on formulation properties. The effects of the different excipients were monitored using the formulations thermal properties, water holding ability and ability to promote the permeation of ibuprofen (IBU and caffeine (CAF)) across silicone membranes. The melting endotherms of the ternary formulations containing 10% w/

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15

Guilbaud, Jean-Baptiste A. M. "Solid-state NMR studies of polymer-drug interactions in pharmaceutical formulations." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486441.

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The development of pharmaceuticals (both drugs and their formulations) requires the characterisation of the materials in their dispensed form. Solid-state NMR is particularly appropriate for studies of such system as it does not require any pre-treatment which might affect the material properties. This methodology also provides a molecular level understanding of intra- and intermolecular bonding as well as the dynamics in pharmaceutical formulations crucial for directing their physical properties, stability, bioavailability and release kinetics of a drug in a composite. Solid-state NMR spectro

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16

Alqurshi, Abdulmalik Abdulrahman M. "Design of freeze-dried formulations for the enhancement of drug release." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/design-of-freezedried-formulations-for-the-enhancement-of-drug-release(089bc9b7-00e2-40eb-98d6-a38078949bb6).html.

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A commonly used approach for the improvement of dissolution and disintegration is to render a poorly soluble drug into its amorphous or disordered form. However, such amorphous materials are physically unstable and are difficult to formulate into oral dosage forms due to their sensitivity to the physical and thermal processes that are involved in production. The first aim of work presented here was to produce the amorphous form of a drug in-situ within a capsule. The second aim was to develop a predominantly amorphous freeze-dried buccal tablet for the rapid delivery of emergency medicine. Nif

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17

Gong, Kenan. "Polymer-drug formulations for controlled release via supercritical fluid assisted impregnation." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497849.

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Poorly water-soluble drugs with limited absorption in the gastrointestinal tract commonly show increased bioavailability when drug dissolution is improved by conversion to the amorphous form or a reduction in particle size. In this study, different polymer matrices were employed to convert model drugs into the amorphous state.

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18

Da, Costa Mathews Claudia Cristina Magalhaes. "An investigation into polymeric excipient-drug compatibility in solid-liquid formulations." Thesis, University of Greenwich, 2007. http://gala.gre.ac.uk/6244/.

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The aim of the investigation was to develop a less empirical way of selecting an appropriate polymeric stabilising agent that would effectively maintain good dispersibility of a given drug substance with known physico-chemical properties. This was achieved by quantifying the adsorption of different polymers onto a range of drug substances from different solvent environments and to establish which physico-chemical properties of the polymers control their adsorption or non-adsorption onto a particular drug. The pharmaceutical actives, two proprietary compounds SB-223412, SB-204269 and loperamide

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19

Weight, Alisha K. (Alisha Kessel). "Enhancing pharmaceutical formulations to improve efficacy and delivery of drug molecules." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82323.

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Thesis (Ph. D. in Biological Chemistry)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Major impediments to the full utility of current and potential drugs include issues of resistance and delivery. To address these challenges, in this thesis two directions of research were pursued: (1) the use of multivalent polymeric inhibitors to overcome drug resistance in human and avian influenza and (2) low-viscosity, high-concentration protein suspensions for therapeutic antibody, in particular monocl

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20

Kulkarni, Chaitrali S. "Novel formulations of a poorly soluble drug using the extrusion process." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/7334.

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Hot melt extrusion has attracted recent interest from the pharmaceutical industry and academia as an innovative drug delivery technology. This novel technique has been shown to be a viable and robust method for preparing different drug delivery systems including pellets, implants, tablets, capsules and granules. The aim of this research was to understand hot melt extrusion processing and explore its pharmaceutical applications. Two applications of hot melt extrusion (HME) have been investigated to improve the properties of poorly soluble thermolabile drugs; polymeric solid dispersions and soli

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21

Russell, Danielle G. R. "Development of liquid formulations for targetted drug delivery to the oesophagus." Thesis, Aston University, 2006. http://publications.aston.ac.uk/11036/.

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22

Robertson, Debra Louise Norton. "Effect of carrier shape and texture on drug availability of aerosolised particles." Thesis, University of Bath, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389946.

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23

Quigley, Karen Josephine. "Factors influencing formation and the in vitro drug release from pellets containing chitosan." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266848.

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24

Barea, Matthew Ernest John. "An investigation into liposomal formulations for targeted drug delivery to the colon." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3430/.

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Recent studies have shown the numerous advantages associated with specific drug delivery to the colon, highlighting its favourable conditions and long transit time as the main advantages. A number of in vitro studies also show that the delivery of liposomes to the colon could provide further advantages due to bonding to the colonic mucosa in both healthy and inflamed regions. Despite these apparent advantages no oral liposomal formulation has been developed for targeted delivery to the colon as yet. Initially, experiments were conducted in which liposomes were directly coated with the pH respo

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25

Souto, Eliana Maria Barbosa. "SLN and NLC as drug carriers of clotrimazole for hydrogel topical formulations." Master's thesis, Porto : [Edição do Autor], 2003. http://hdl.handle.net/10216/63983.

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26

Souto, Eliana Maria Barbosa. "SLN and NLC as drug carriers of clotrimazole for hydrogel topical formulations." Dissertação, Porto : [Edição do Autor], 2003. http://catalogo.up.pt/F?func=find-b&local_base=UPB01&find_code=SYS&request=000095818.

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27

Ellison, Mark. "An investigation of the physicochemical and rheological properties of drug-gel formulations in relation to drug release mechanisms." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361471.

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28

Lim, Howard J. "Role of liposome mediated drug delivery and drug release in determining the therapeutic activity of liposomal formulations of mitoxantrone." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://hdl.handle.net/2429/10000.

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Although liposomal accumulation at the target site is an important issue, the critical parameter defining the activity of a liposomal formulation is drug release, a factor that includes where, when, and how fast the therapeutic agent dissociates from the liposomal carrier. This point was investigated using two liposomal formulations of the anti-cancer drug mitoxantrone. Mitoxantrone was encapsulated via a pH gradient method in liposomes prepared of 1,2 distearoyl-sn-glycero-3-phosphocholine (DSPC)/cholesterol (Choi) (55:45 mol ratio) or 1,2 dimyristoyl-sn-glycero-3-phosphocholine (DMPC)/

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29

Peagram, Rebecca Elizabeth. "Emulsion formulations as delivery systems for soluble protein subunit viral vaccines." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363615.

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30

Cabral, Renato Manuel Pereira. "Development of chitosan-based microparticles for pulmonary drug delivery." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10505.

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Dissertação para obtenção do Grau de Mestre em Engenharia Química e Bioquímica<br>In this work, novel chitosan (CHT) based microparticles were prepared using supercritical assisted atomization (SAA) and evaluated as potential carriers for sustained pulmonary drug delivery. CHT is a polysaccharide comprising of glucosamine and N-acetylglucosamine units, it is biodegradable, biocompatible and non-toxic being an interesting choice to be used as a drug carrier for inhalation therapy and belongs to the group of swellable polymers. By utilizing SAA, spherical microparticles containing a sharp parti

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31

Chaw, Cheng Shu. "The gastric emptying and drug absorption of liquid formulations of 4-aminosalicylic acid." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327130.

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32

Owen, J. W. "Magnetic microbubbles : investigation and design of new formulations for targeted therapy." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:47537fb2-76e2-4e84-94bf-1530c57ff25a.

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Targeted therapy is a significant area of research in pharmaceutical and biomedical science. Its overall aim is to achieve maximum impact on malignant cells with minimum side effects to healthy tissue. In this thesis the capabilities of magnetic microbubbles as targeted therapeutic delivery vehicles are explored. New characterisation techniques were developed in order to understand and improve the current magnetic microbubble formulation. Electron microscopy was used to analyse the nanoscale structure of microbubble shells and observe nanoparticles attached to the shell surface. A new flow pha

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33

Jones, Tanya. "Development of a Novel Implant for Drug Delivery." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/367574.

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Background and aim: In situ gelling formulations are liquids that undergo a phase transition to form semi-solid gel structures within the physiological environment. Sustained release of drug products can therefore be delivered via injectable in situ gelling formulations where the gel formed in vivo acts as a drug reservoir, releasing drug via diffusion and/or degradation of the gel. Due to limitations of previously described in situ gelling formulations, the current research project aimed to address these issues and develop a biocompatible injectable in situ gelling formulation/s containing a

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34

Utting, Anita A. "Liquid filled hard gelatin capsules : an investigation of thermosoftened drug/poloxamer solid dispersion formulations in relation to drug release mechanisms." Thesis, University of Sunderland, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327315.

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35

Sek, Leab 1973. "An in vitro model of lipid digestion for assessing the oral bioavailability enhancement potential of lipidic formulations." Monash University, Dept. of Pharmaceutics, 2002. http://arrow.monash.edu.au/hdl/1959.1/8215.

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36

Eriksson, Johnny. "Dissolution rate of poorly soluble drugs : Potential influence on dissolution rate using calcium sulfate as carrier in drug formulations." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-65816.

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37

Bahl, Paul. "Development of medicated chewing gum formulations for the delivery of a poorly soluble drug." Thesis, University of Huddersfield, 2015. http://eprints.hud.ac.uk/id/eprint/25435/.

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The concept of chewing gum for medical purposes provides discrete, convenient administration, the potential for buccal absorption and the avoidance of first pass metabolism or gastrointestinal degradation. This work contributes to the limited information available on the release of poorly soluble drugs from medicated chewing gum formulations. Lansoprazole was chosen as a model drug due to its poor solubility and instability (under acidic conditions), thus a chewing gum formulation would be of particular benefit avoiding gastrointestinal degradation. The solubility and stability of lansoprazole

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38

Petersson, Karsten. "Combined formulations based on prodrugs and in situ gelling systems : design and pharmaceutical chemical characterisation /." [Cph.] : The Danish University of Pharmaceutical Sciences, Department of Pharmaceutics, 2004. http://www.dfh.dk/phd/defences/karstenpetersson.htm.

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39

Bello, Hussaini. "Physiochemical and drug release properties of liquisolid formulations in comparison to their physical mixture counterparts." Thesis, University of Wolverhampton, 2018. http://hdl.handle.net/2436/621794.

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Various techniques have been used for modifying the release properties of drugs over the past years. Techniques such as liquisolid technology have raised a lot of interest in many researchers which can be employed to enhance or sustain dissolution. Various liquisolid (LS) tablets of diltiazem containing Polysorbate 80 as a non-volatile solvent for sustained release were prepared. PolyoxTM is an attractive pharmaceutical polymer used in controlled release dosage forms mainly because of its insensitivity to the pH of the biological medium and ease of production. The aim of this study was to inve

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40

Lee, Ryan Thomas. "Modulation of Keratin Biomaterial Formulations for Controlled Mechanical Properties, Drug Delivery, and Cell Delivery Applications." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1385549579.

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41

Grove, Mette. "Development and characterisation of lipid-based formulations for oral delivery of poorly soluble drug substances /." Cph. : The Danish University of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, 2006. http://www.dfuni.dk/index.php/Mette_Grove/3071/0/.

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42

Depreter, Flore. "Development of dry powder formulations of proteins for inhalation." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209719.

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A number of therapeutic proteins are used for long in clinical practice. These include for example insulin, calcitonine, growth hormone, and parathyroid hormone for the treatment of various systemic disorders, as well as protein antigens in vaccine formulations. Due to the recent developments in biochemical engineering and in the comprehension of the physiopathology of many diseases, peptides and proteins are expected to become a drug class of increasing importance. Recently, novel biological drugs have for example been developed such as monoclonal antibodies, antibody fragments, soluble recep

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43

Rojas, Labanda Paula Elena. "CO2-expanded solvents, promising green solvents for preparing effective formulations of poorly soluble actives." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/289637.

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La industria farmacéutica hoy en día tiene que afrontar varios retos ya que el 40\% de los compuestos resultantes de los programas de selección combinatorios son insolubles en agua. Como consecuencia, estas moléculas presentan dificultades a la hora de ser procesadas. Una de las estrategias más implementadas para aumentar la velocidad de disolución de estos nuevos fármacos es su formulación como microparticulas. Las propiedades de los ingredientes activos están directamente relacionadas con las características de las partículas tales como el tamaño, la forma, la estructura cristalina y la morf

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44

Ørskov, Christensen Janne. "Evaluation of an in vitro lipid digestion model : testing poorly soluble drug substances and lipid-based formulations /." [Cph.] : Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/jannechristensen.htm.

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45

Östh, Karin. "The Horizontal Ussing Chamber Method in Studies of Nasal Drug Delivery : Method Development and Applications Using Different Formulations." Doctoral thesis, Uppsala University, Department of Pharmacy, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2874.

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<p>The results from this thesis leads to the following conclusions; HUM is a useful tool that fills a gap in the in vitro methods previously available to study nasal drug delivery. Using HUM, the pig respiratory nasal mucosa can obtain acceptable viability and retain it longer than the period of time needed for a transport experiment. HUM has proven to be an appropriate tool for the study of liquids in low volume, gels, both unmodified and with controlled release properties, and particle suspensions. The potential local toxicity of formulations such as controlled release gels and surfactants c

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46

Mofidfar, Mohammad. "POLYMERIC NANOFIBER/ANTIMICROBIAL FORMULATIONS USING A NOVEL CO-EXTRUSION APPROACH COMPARED WITH ELECTROSPINNING FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1482512576465589.

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47

Khoshakhlagh, Pooneh [Verfasser]. "FaSSIF-C, a Cholesterol containing biorelevant intestinal model medium for development and test of oral drug formulations / Pooneh Khoshakhlagh." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/1080335692/34.

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48

Nykänen, Pirjo. "Development of multiple-unit oral formulations for colon-specific drug delivery using enteric polymers and organic acids as excipients." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/nykanen/.

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49

Shriky, Banah. "Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17364.

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This study seeks to develop smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems owing its low gelation concentration and ease of modification the system properties through excipients addition. The matrix properties were studied through a series of thermal, rheological and structural (SAXS/SANS) experiments as a function of concentration and shear rate, covering both static and dyna

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50

Tuli, Rinku. "Studies on the surface properties of biodegradable polymer carriers in respiratory delivery of drug from Dry Powder Inhaler formulations." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53295/1/Rinku_Tuli_thesis.pdf.

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Dry Powder Inhaler (DPI) technology has a significant impact in the treatment of various respiratory disorders. DPI formulations consist of a micronized drug (<5ìm) blended with an inert coarse carrier, for which lactose is widely used to date. DPIs are one of the inhalation devices which are used to target the delivery of drugs to the lungs. Drug delivery via DPI formulations is influenced by the physico-chemical characteristics of lactose particles such as size, shape, surface roughness and adhesional forces. Commercially available DPI formulations, which utilise lactose as the carrier, are

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