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Journal articles on the topic 'And drug formulations'

Author: Grafiati

Published: 7 June 2025

Last updated: 17 July 2025

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1

Khan, Rahman Ullah, Shefaat Ullah Shah, Sheikh Abdur Rashid, et al. "Lornoxicam-Loaded Chitosan-Decorated Nanoemulsion: Preparation and In Vitro Evaluation for Enhanced Transdermal Delivery." Polymers 14, no. 9 (2022): 1922. http://dx.doi.org/10.3390/polym14091922.

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Nanoemulsions are promising drug delivery systems for the administration of poorly soluble drugs like lornoxicam (LRX) by oral or parenteral routes. Such formulations work perfectly for transdermal delivery of lornoxicam-type drugs. It has also been established that formulating such a delivery system is highly dependent on the presence, type, and concentration of excipients taking part in the formulation. The inherent characteristics of nanoemulsion (NE), i.e., smaller globule size and excipient nature, facilitate the drug’s passage through skin. The current study was aimed at the development

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Amarsing, Tadavi S., and Pawar S. Pandit. "Development of Nasal In-situ Gel Formulation of Fexofenadine HCl Using Gellan Gum (Gelerite®)." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 01 (2023): 54–60. http://dx.doi.org/10.25258/ijpqa.14.1.10.

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This study aimed to develop and assess an in-situ nasal gel containing fexofenadine hydrochloride for nasal administration by employing polymers with in-situ gelling characteristics. Formulations containing Gelerite, HPMC K4M and β-cyclodextrin were used to formulate in situ nasal gel. Formulations were liquid before administration and quickly converted to gel after nasal administration. The FTIR studies of drugs, polymers and physical mixtures of drug polymers were carried out. These research results indicated that, in comparison to pure drugs, there have been no considerable modifi cations i

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Akiro F., Tugonza. "Engineering Novel Drug Formulations: Challenges and Opportunities." NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY 6, no. 1 (2025): 20–26. https://doi.org/10.59298/nijpp/2025/612026.

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The development of novel drug formulations is a crucial aspect of pharmaceutical research, ensuring enhanced drug efficacy, bioavailability, and patient compliance. Despite significant advancements, challenges such as poor solubility, stability issues, and regulatory constraints continue to hinder the formulation of new drugs. This paper examines fundamental concepts in drug formulation, highlighting the limitations of conventional approaches and the emergence of advanced technologies, including nanotechnology-based formulations. Innovations in targeted delivery systems and the integration of

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Guggila Niharika, Mekala Pallavi, and Arumugam Yasodha. "Formulation and evaluation of Ebastine transferosomes." World Journal of Biology Pharmacy and Health Sciences 19, no. 1 (2024): 393–400. http://dx.doi.org/10.30574/wjbphs.2024.19.1.0446.

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The present study was focused on formulating and evaluating Ebastine containing Transferosomes formulation for in vitro studies. Transferosomes formulations were prepared by using cold method and were evaluated for in vitro characteristics, stability studies. Transferosomes formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that Transferosomes formulation was spherical in shape. Transferosomes containing lipid higher percentage of drug release after 8 h as compared to other formulations. F-2 formulation was found to be stable at the end of the s

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Gayathri, B. Leela, T. Pavani, P. Ram Prathap, et al. "Formulation and evaluation of dipotassium clorazepate topical gels." International Journal of Experimental and Biomedical Research 4, no. 1 (2025): 26–36. https://doi.org/10.26452/ijebr.v4i1.719.

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This investigation aimed to formulate and evaluate a topical gel containing dipotassium clorazepate. To achieve the desired drug release, a topical gel containing dipotassium clorazepate was synthesized using the dispersion method. Three different gelling agents, carbopol 934p, HPMC K100, and sodium alginate, were used in four different ratios. Twelve gel formulations of dipotassium clorazepate that had been prepared were assessed for stability, drug release kinetics, drug diffusion, pH measurement, viscosity, and drug content. Drug-polymer compatibility studies were done using the Fourier Tra

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Kadhum, Wesam R., Gerard Lee See, Muqdad Alhijjaj, et al. "Evaluation of the Skin Permeation-Enhancing Abilities of Newly Developed Water-Soluble Self-Assembled Liquid Crystal Formulations Based on Hexosomes." Crystals 12, no. 9 (2022): 1238. http://dx.doi.org/10.3390/cryst12091238.

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The present study aimed to develop polyethylene glycol–liquid crystals (PEG-LC) ointment formulations, assess their formulation characteristics, and establish their biocompatibility and impact on transdermal drug administration. PEG-LC formulations were prepared using a hydrophilic molecule, p-aminobenzoic acid (PAB). Formulation characterizations such as small-angle X-ray scattering, viscosity, pH, zeta potential, and the particle sizes of the formulations were examined to determine the physicochemical properties of the prepared formulations. The drug release profile of PEG-LC ointment formul

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Guggila, Niharika, Pallavi Mekala, and Yasodha Arumugam. "Formulation and evaluation of Ebastine transferosomes." World Journal of Biology Pharmacy and Health Sciences 19, no. 1 (2024): 393–400. https://doi.org/10.5281/zenodo.13789923.

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The present study was focused on formulating and evaluating Ebastine containing Transferosomes formulation for <em>in vitro</em> studies. Transferosomes formulations were prepared by using cold method and were evaluated for <em>in vitro</em> characteristics, stability studies. Transferosomes formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that Transferosomes formulation was spherical in shape. Transferosomes containing lipid higher percentage of drug release after 8 h as compared to other formulations. F-2 formulation was found

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Malamatari, Maria. "The Importance of Drug Delivery in the Clinical Development and Lifecycle of Drug Products with Examples from Authorised Medicinal Products." Processes 11, no. 10 (2023): 2919. http://dx.doi.org/10.3390/pr11102919.

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Drug delivery systems (DDS) are formulations or devices that enable the introduction of a therapeutic into the body and its delivery to its target site, potentially enhancing its efficacy and safety. Advances in formulation approaches related to the enhancement of solubility, permeability and thus bioavailability of drugs have already been successfully implemented by the pharmaceutical industry. This review highlights the importance of formulations/DDS in the clinical development and the lifecycle of drug products. Examples from already authorised drug products have been used to showcase how t

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9

Ashok, Kumar Sharma, Pushpendra Singh Naruka Dr., Shankar Soni Mr., Mohit Khandelwal Mr., Shaneza Aman Ms., and Sharma Mukesh. "DEVELOPMENT AND EVALUATION HYDROGEL OF KETOCONAZOLE." International Journal of Current Pharmaceutical Review and Research 11, no. 3 (2019): 01–11. https://doi.org/10.5281/zenodo.12672946.

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The main aim of this study was to develop a topical drug delivery (Hydrogel) ofKetoconazole to reduce the dose of the active drug, to improve patient compliance, to avoidthe side effects and increase local onset absorption and action. Ketoconazole interfarewith 14-α sterol demethylase, a cytochrome P-450 enzyme essential for conversion oflanosterol to ergosterol. These turn in inhibition in synthesis of ergosterol and also enhancecellular permeability of fungus due to reduced amounts of ergosterol present in the fungal cellmembrane. Methods: Topical Hydrogel formulations development of K

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Shrestha, Hina, Rajni Bala, and Sandeep Arora. "Lipid-Based Drug Delivery Systems." Journal of Pharmaceutics 2014 (May 19, 2014): 1–10. http://dx.doi.org/10.1155/2014/801820.

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The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulations can be tailored to meet a wide range of product requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. These formulations

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Buruju Vennela, Arumugam Siva Kumar, Kassa Jyothi, and Arumugam Yasodha. "Development and characterization of Decitabine Niosomes." World Journal of Biology Pharmacy and Health Sciences 19, no. 1 (2024): 382–92. http://dx.doi.org/10.30574/wjbphs.2024.19.1.0445.

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The present study was focused on formulating and evaluating Decitabine containing niosomes formulation for In Vitro studies. Niosomal formulations were prepared by using different ratio of surfactant (Tween 80 and Tween 20) and cholesterol by thin film hydration method and were evaluated for In Vitro characteristics, stability studies. Span 20 containing niosomal formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that niosomal formulation was spherical in shape. Niosomes containing Tween 20 displayed higher percentage of drug release after 8 h a

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Ahmad, Muhammad Masood, Tanveer Ahmed Khan, and Kasatkin Valery. "PRELIMINARY STUDIES ON THE PHYSICAL PARAMETERS OF ORODISPERSIBLE TABLETS USING SUPERDISINTEGRANTS." Hamdard Journal of Pharmacy 1, no. 1 (2021): 23–31. http://dx.doi.org/10.61744/hjp.v1i1.57.

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There are various routes of drug administration available such as oral, sublingual, inhalation, and rectal. Among all, the oral route of drug administration is most widely used. Tablet is the most popular dosage form among all existing dosage forms. The most conventional tablets are immediate release but these tablets are only suitable for drugs with high solubility and high permeability. In this study, five different Orodispersible tablet formulations were prepared. Various Natural and Synthetic super disintegrants were used in all formulations including Plantago Ovata (F1), Sodium Alginate (

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Buruju, Vennela, Siva Kumar Arumugam, Jyothi Kassa, and Yasodha Arumugam. "Development and characterization of Decitabine Niosomes." World Journal of Biology Pharmacy and Health Sciences 19, no. 1 (2024): 382–92. https://doi.org/10.5281/zenodo.13789911.

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The present study was focused on formulating and evaluating Decitabine containing niosomes formulation for <em>In Vitro </em>studies. Niosomal formulations were prepared by using different ratio of surfactant (Tween 80 and Tween 20) and cholesterol by thin film hydration method and were evaluated for <em>In Vitro </em>characteristics, stability studies. Span 20 containing niosomal formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that niosomal formulation was spherical in shape. Niosomes containing Tween 20 displayed higher

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14

Allegaert, Karel. "Drug formulations." Biomedical & Life Sciences Collection 2024, no. 10 (2024): e1006563. http://dx.doi.org/10.69645/squg7671.

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Shekh, Binyamin, and Revathi A. Gupta. "Formulation and Optimization of Liquisolid Compact for Enhancing Dissolution Properties of Polyphenol Stilbenoid- Resveratrol." Journal of Drug Delivery and Therapeutics 12, no. 6-S (2022): 65–72. http://dx.doi.org/10.22270/jddt.v12i6-s.5707.

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Resveratrol is a class II drug in the Biopharmaceutics Classification System (BCS) with poor water solubility (0.03 mg/ml) and high permeability. Liquisolid system is an innovative technique used for enhancing dissolution rate and bioavailability of poorly soluble drugs. The present study demonstrated that Resveratrol loaded SNEDDS and Liquisolid compacts were successfully developed. Ten SNEDDS formulation were formulated with different ratio oil, surfactant and co-surfactant. Out of ten formulations four were selected based on dilution and self-emulsification time. Out of four formulations F4

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Thamanna, P., and Prasanth M. L. Lal. "Comparative review on polyherbal and monoherbal cosmetic formulations." i-manager's Journal on Chemical Sciences 3, no. 1 (2023): 32. http://dx.doi.org/10.26634/jchem.3.1.19379.

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This comparative review explores the characteristics and benefits of polyherbal and monoherbal cosmetic formulations. Formulations containing two or more herbs are called polyherbal formulations. Drug formulation in Ayurveda is based on the use of a single drug or more than one drug. A monoherbal formulation contains only one herb. The problem of polyherbal formulation occurs due to sources and manufacturing processes, patients, drug-herb interaction, toxicity, and improper manufacturing. Polyherbal formulations mean the use of more than one herb in a therapeutic preparation. In Ayurveda, mult

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Ravichandran, Vasanthan, Minjong Lee, Thuy Giang Nguyen Cao, and Min Suk Shim. "Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy." Applied Sciences 11, no. 19 (2021): 9336. http://dx.doi.org/10.3390/app11199336.

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Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives. Recently, various PS-based formulations have been developed for safe and efficient drug delivery. This review introduces the general features of PSs and PS-based drug carriers, summarizes recent progress in the development of PS-based drug formulations, and discusses the physicochemical properties, biological safety, P-glycoprotein inhibitory properties, and therapeutic applicatio

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Shilakari Asthana, Gyati, Parveen Kumar Sharma, and Abhay Asthana. "In VitroandIn VivoEvaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin." Scientifica 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/6492953.

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The present study was focused on formulating and evaluating clarithromycin (CLR) containing niosomal formulation forin vitroandin vivopharmacokinetic behavior. Niosomal formulations (empty and drug loaded) were prepared by using different ratio of surfactant (various Span grades 20, 40, 60, and 80) and cholesterol by thin film hydration method and were evaluated forin vitrocharacteristics, stability studies, andin vivostudy. Dicetyl phosphate (DCP) was added to the niosomal formulation. Various pharmacokinetic parameters were determined from plasma of male SD rats. Span 60 containing niosomal

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Ren, Ping, Theresa Chan, Wen-Cheng Yang, et al. "Effect of the Similarity of Formulations and Excipients of Approved Generic Drug Products on In Vivo Bioequivalence for Putative Biopharmaceutics Classification System Class III Drugs." Pharmaceutics 15, no. 9 (2023): 2366. http://dx.doi.org/10.3390/pharmaceutics15092366.

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One of the potential essential factors that restricts generic industry from applying the Biopharmaceutics Classification System (BCS) Class III biowaiver is adherence to the stringent formulation criteria for formulation qualitative (Q1) sameness and quantitative (Q2) similarity. The present study has investigated formulations and excipients from 16 putative BCS Class III drug substances in a total of 19 drug products via 133 approved abbreviated new drug applications (ANDAs) containing in vivo bioequivalence (BE) studies in human subjects during the time period from 2006 to 2022. We included

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Barber, Bryce W., Camille Dumont, Philippe Caisse, George P. Simon, and Ben J. Boyd. "A 3D-Printed Polymer–Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations." Pharmaceutics 13, no. 12 (2021): 2107. http://dx.doi.org/10.3390/pharmaceutics13122107.

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3D printing is a rapidly growing area of interest within pharmaceutical science thanks to its versatility in creating different dose form geometries and drug doses to enable the personalisation of medicines. Research in this area has been dominated by polymer-based materials; however, for poorly water-soluble lipophilic drugs, lipid formulations present advantages in improving bioavailability. This study progresses the area of 3D-printed solid lipid formulations by providing a 3D-printed dissolvable polymer scaffold to compartmentalise solid lipid formulations within a single dosage form. This

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Raouf, Abdur, Fahad Pervaiz, Hafiz Muhammad Usman Abid, et al. "ITRACONAZOLE SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM: A COMPREHENSIVE STUDY ON BCS CLASS II DRUG TRANSFORMATION FOR OPTIMAL ORAL DELIVERY." Insights-Journal of Health and Rehabilitation 3, no. 3 (Health & Rehab) (2025): 255–72. https://doi.org/10.71000/cv3d6d35.

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Background: Itraconazole, a BCS Class II antifungal agent, exhibits poor water solubility and variable oral bioavailability, limiting its therapeutic efficacy. Self-nanoemulsifying drug delivery systems (SNEDDS) have emerged as an effective strategy for improving drug dissolution and absorption. By enhancing solubility and ensuring rapid drug release, SNEDDS formulations offer a promising alternative to conventional dosage forms. This study focuses on the development and evaluation of an optimized SNEDDS formulation for itraconazole to improve its oral bioavailability and therapeutic potential

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Ubhe, Anand, and Gerard G. M. D’Souza. "Preparation and Evaluation of Polymeric Microparticles of Human Recombinant IL-1 Receptor Antagonist by Spray Drying." Drug Delivery Letters 10, no. 4 (2020): 308–13. http://dx.doi.org/10.2174/2210303110999200727171802.

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Background: Formulating protein drugs into delivery systems with high drug loading is particularly challenging. Another major hurdle for formulation processes generally used for protein drugs is their scalability. In this article, we present the application of spray drying to prepare polymeric microparticles of human recombinant IL-1 receptor antagonist (IL-1 ra). Objective: The objective of this study was to formulate polymeric microparticles entrapping a therapeutic protein, human recombinant IL-1 ra using a spray drying process. Methods: IL-1 ra was formulated using three polymers viz. gela

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Dhiman, Jasmine, and Priya Sharma. "Optimizing Liposomal Drug Delivery for Enhanced Efficacy in Skin Cancer Treatment: A Comprehensive Experimental Investigation." Journal of Drug Delivery and Therapeutics 14, no. 6 (2024): 87–97. http://dx.doi.org/10.22270/jddt.v14i6.6566.

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Skin cancer is a prevalent global health issue, necessitating ongoing research into innovative treatment approaches. This study focuses on assessing the effectiveness of a liposomal formulation to enhance skin cancer treatment and demonstrates its technological viability. A comprehensive literature review establishes the context by examining current skin cancer treatments and the role of liposomal formulations in dermatological therapies. The research objectives are clearly outlined, detailing the liposomal formulation's characteristics and experimental methodologies. Results from the study, i

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Kuldeep Bairwa, Amit Jain. "Formulation and characterization of medicated chewing gum containing zingiberine for treatment of throat infections." Tuijin Jishu/Journal of Propulsion Technology 44, no. 3 (2023): 4764–69. http://dx.doi.org/10.52783/tjjpt.v44.i3.2644.

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The objective of this work was to formulate zingiberine as medicated chewing gum for improving its bioavailability. The objective was achieved by isolating zingiberine form ginger oil and formulating chewing gum using zein as the gum base by melting method. The formulation of ZCGs was achieved using melting method. Zein was used as the gum base, glycerine as the plasticizer, sucrose and mannitol as the sweeteners and peppermint oil as the flavoring agent. The amount of drug contained in the formulations was uniform in all the formulations and ranged from 94.4 to 96.2%. Release of drug from ZCG

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Priya, B. Panchal G. N. Dhembre* U. T. Jadhao S. T. Thoke D. A. Rathod S. A. Wathore V. R. Kauthekar. "Development And Evaluation Of Orodispersible Film Of Telmisartan." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 1652–61. https://doi.org/10.5281/zenodo.14000663.

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The objective of this research work was the Development and evaluation of Orodispersible film of Telmisartan as model drug. This formulation was aimed to deliver the quick onset of action of drug Telmisartan in the management of hypertension, so as to enhance patient’s compliance. The orodispersible film of Telmisartan was prepared by solvent casting method. Orodispersible film of Telmisartan was formulated using two different film forming agent HPMC E5 and Pullulan along with crosspovidone as a superdisintegrant.Total six formulations were developed using varying concentration of film f

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Nakka, Samantha A. Jayasree Praneetha. D. *. "FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF METOCLOPRAMIDE HYDROCHLORIDE." Journal of Scientific Research in Pharmacy 09, no. 08 (2020): 13–18. https://doi.org/10.5281/zenodo.7626012.

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<strong><em>ABSTRACT</em></strong> <strong> Recent advances in novel drug delivery aims to enhance the safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. One such approach is oral disintegrating tablets. Oro-dispersible tablets are a suitable means of drug delivery system for better patient compliance, rapid onset of action, increased bioavailability. The purpose of the present research was to formulate and evaluate the mouth disintegrating tablets of metoclopramide hydrochloride. Metoclopramide

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Singh, Pritam. "PREPARATION, CHARACTERIZATION AND DISSOLUTION STUDY OF SPRAY DRIED SOLID DISPERSIONS OF SIMVASTATIN WITH PVP K25 AND AEROSIL 200." Journal of Medical pharmaceutical and allied sciences 10, no. 6 (2021): 3806–12. http://dx.doi.org/10.22270/jmpas.v10i6.1374.

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BCS class II is well-known for the drugs, having poor aqueous solubility and high permeability. Simvastatin is also categorized as BCS class II, suffering from poor aqueous solubility, affecting its bioavailability. In an attempt to resolve this problem, solid dispersions of simvastatin were prepared by spray-drying method. Solid dispersions of simvastatin with PVP K25 and aerosol in ratio (1:1:1 to 1:5:1) and without aerosil 200 (1:1 to 1:5) were prepared by spray drying method. The dissolution test showed the enhancement of dissolution as compared to the pure drug and nearly equal to markete

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Efendy Goon, Danial, Siti Hamimah Sheikh Abdul Kadir, Normala Ab Latip, Sharaniza Ab. Rahim, and Musalmah Mazlan. "Palm Oil in Lipid-Based Formulations and Drug Delivery Systems." Biomolecules 9, no. 2 (2019): 64. http://dx.doi.org/10.3390/biom9020064.

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Palm oil is natural oil packed with important compounds and fatty acids ready to be exploited in lipid-based formulations and drug delivery. Palm oil and palm kernel oil contain long-chain and medium-chain triglycerides, respectively, including phytonutrients such as tocotrienol, tocopherol and carotenes. The exploitation of these compounds in a lipid-based formulation would be able to address hydrophobicity, lipophilicity, poor bioavailability and low water-solubility of many current drugs. The utilisation of palm oil as part of the drug delivery system seemed to improve the bioavailability a

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Ashok, Kumar Sharma, and Singh Naruka Pushpendra. "DESIGN, DEVELOPMENT AND EVALUATION OF BIGEL BASED DELIVERY OF AMPHOTERICIN-B AND MICONAZOLE IN THE TREATMENT OF FUNGAL." International Journal of Current Pharmaceutical Review and Research 14, no. 01 (2022): 72–81. https://doi.org/10.5281/zenodo.12666156.

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The main aim of present study was to develop a recent advanced Bigel topical drug deliveryof Amphotericin-B and Miconazole to improve patient compliance, to avoid the side effects,first pass metabolism and increase local onset absorption and action. polyene antifungals,amphotericin B associates with ergosterol, the main component of fungal cell membranes,forming a transmembrane channel that acts as monovalent ion (K+, Na+, H+ and Cl−)leakage, which is the primary effect resulting in fungal cell death. Miconazole interfare with14-α sterol demethylase, a cytochrome P-450 enzyme essen

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Grüne, Linda, and Heike Bunjes. "Solubility of Poorly Soluble Drugs in Phosphatidylcholine-Based Drug Delivery Systems: Comparison of the Loading Capacity in the Bulk Formulation and Its Dispersed State." Pharmaceuticals 17, no. 3 (2024): 400. http://dx.doi.org/10.3390/ph17030400.

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The aim of this study was to determine the drug loading capacity of phosphatidylcholine-based formulations for four poorly water-soluble drug substances (clofazimine, fenofibrate, artemether, cannabidiol). Two self-dispersing lipid formulations were investigated, which consisted of soybean phospholipids, medium-chain triglycerides and ethanol with a different phospholipid–oil ratio. The direct loading of the bulk formulation was conducted with dual centrifugation, which proved to be a suitable method for screening experiments with the highly viscous formulations. To estimate possible precipita

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Srinivasan, Uma Shankar Marakanam, Vishnu Vishnu, Sharmila Sharmila, and Amod Kumar. "FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE TOPICAL GEL FOR WOUND INFECTIONS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 369. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26150.

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Objective: The objective of this research work was to formulate and evaluate topical gel loaded with cefixime trihydrate, a third-generation cephalosporin antibiotic for the treatment of bacterial wound infections.Methods: The cefixime trihydrate gel was formulated using polymers such as Carbopol 940 and hydroxypropyl methylcellulose E4M in varying concentrations. Three different formulations were prepared and characterized physically for color, syneresis, spreadability, pH, drug content, and rheological properties. In vitro drug release in phosphate buffer pH 7.4 and antibacterial study were

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Mohanan, Shan, Nabeela Rasheed, and Bimal Raj K S. "FORMULATION AND EVALUATION OF ANTIMICROBIAL GELS FOR THE TREATMENT OF PARONYCHIA." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 161. http://dx.doi.org/10.22159/ijap.2018v10i6.28266.

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Objective: The aim of the study was to design and develop a gel based drug delivery system containing combinational drugs (ketoconazole, neomycin sulphate and diclofenac) for the effective treatment of Paronychia.Methods: The drugs used are ketoconazole, neomycin sulphate and diclofenac. The first two drugs provide an antifungal and antibacterial action and the last drug with a pain relieving effect. Two formulations of gels F1 and F2 were prepared using polymers like carbopol 934 and xanthan gum respectively. The amounts of drugs and other ingredients were kept as constant in both formulation

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Salfi, Roshan, Fatima Shireen, and Makula Ajitha. "Optimization of Repaglinide Osmotic Drug Delivery System Using Two Different Techniques." International Journal of Pharmaceutical Sciences and Drug Research 14, no. 01 (2022): 29–36. http://dx.doi.org/10.25004/ijpsdr.2022.140104.

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The current study aimed to formulate an elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) based drug delivery system for controlled release of an anti-diabetic agent, repaglinide is expected to provide sustained release. EOP and PPOP method prepared repaglinide tablets by wet granulation technique. EOP designed 15 formulations F1-F15 and 14 formulations were done by PPOP method. All the formulations were evaluated for various physicochemical parameters and in-vitro dissolution studies. The release data was fitted into mathematical kinetic modeling studies to check the release mec

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MOURTAS, SPYRIDON, JOHN MAO, CHRISTOPHE C. PARSY, RICHARD STORER, PAVLOS KLEPETSANIS, and SOPHIA G. ANTIMISIARIS. "LIPOSOMAL GELS FOR VAGINAL DELIVERY OF THE MICROBICIDE MC-1220: PREPARATION AND IN VIVO VAGINAL TOXICITY AND PHARMACOKINETICS." Nano LIFE 01, no. 03n04 (2010): 195–205. http://dx.doi.org/10.1142/s1793984410000225.

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MC-1220 is a highly potent and selective non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV. The objective is to develop formulations for the vaginal delivery of MC-1220 and characterize them in vitro and in vivo (drug uptake, pharmacokinetics, toxicokinetics and vaginal irritation/inflammation). Due to the low aqueous solubility of MC-1220, emulsion-type and liposomal formulations of MC-1220 were developed. After rheological property adjustment (by gelling agents), the toxicity of two types of vaginal formulations of MC-1220 (emulsion [E] and liposomal [LIP] formulations) at 0.1% (

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Akhlaq, Muhammad, Abul Kalam Azad, Shivkanya Fuloria, et al. "Fabrication of Tizanidine Loaded Patches Using Flaxseed Oil and Coriander Oil as a Penetration Enhancer for Transdermal Delivery." Polymers 13, no. 23 (2021): 4217. http://dx.doi.org/10.3390/polym13234217.

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Transdermal drug delivery is important to maintain plasma drug concentrations for therapeutic efficacy. The current study reports the design, formulation, and evaluation of tizanidine transdermal patches formulated using chitosan and thiolated chitosan, ethyl cellulose (EC), polyvinylpyrrolidone (PVP), and Eudragit RL100 in different ratios. The tizanidine patches were formulated using flaxseed oil and coriander oil in the concentrations of 1% v/w, 2% v/w, 3% v/w, 4% v/w, 5% v/w, and 10% v/w. The patches were subjected to characterization of physicochemical property (thickness, weight uniformi

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Neha, Yadav, Vijay Singh Kavita, Bansal Mayank, and Gupta Manoj. "Design, Development and Evaluation of Bigel-Based Drug Delivery of Amphotericin-B." International Journal of Current Pharmaceutical Review and Research 15, no. 05 (2023): 173–80. https://doi.org/10.5281/zenodo.12608885.

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AbstractTopical administration is applied to deliver a drug instantaneously at the point of application,so enough drugs is depleted into the systemic circulation to cause medicinal effects. Todevelop an effective drug absorption through an intact skin, several topical preparations areused one of that is “Gels”. Gels basically used for the purpose of topical dosage form a lotwhich is to deliver drug across a localized area of the skin. The main aim of present studywas to develop a recent advanced Bigel topical drug delivery of Amphotericin-B to improvepatient compliance, to avoid th

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Justen, Anna, Gerhard Schaldach, and Markus Thommes. "Insights into the Mechanism of Enhanced Dissolution in Solid Crystalline Formulations." Pharmaceutics 16, no. 4 (2024): 510. http://dx.doi.org/10.3390/pharmaceutics16040510.

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Solid dispersions are a promising approach to enhance the dissolution of poorly water-soluble drugs. Solid crystalline formulations show a fast drug dissolution and a high thermodynamic stability. To understand the mechanisms leading to the faster dissolution of solid crystalline formulations, physical mixtures of the poorly soluble drugs celecoxib, naproxen and phenytoin were investigated in the flow through cell (apparatus 4). The effect of drug load, hydrodynamics in the flow through cell and particle size reduction in co-milled physical mixtures were studied. A carrier- and drug-enabled di

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R Lisha Rani, V Gayathri, N Audinarayana, Babu BK, and D Jothieswari. "Formulation characterization and evaluation of In-Situ nasal gels of amitriptyline." World Journal of Advanced Research and Reviews 26, no. 1 (2025): 2428–39. https://doi.org/10.30574/wjarr.2025.26.1.1034.

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The main aim of the present work is to formulate and evaluate Amitriptyline In-Situ Nasal gels. To achieve more constant blood levels with lower dosage of drugs by continuous drug input and by passing hepatic first pass metabolism and consequent degradation. In FTIR & DSC spectra there is no incompatibility between pure drug, polymers & lipids. The Formulation of Amitriptyline hydrochloride In-Situ Nasal gels, The evaluation of Amitriptyline hydrochloride In-Situ Nasal gels. Carbopol containing gels were found to be sparkling and transparent Poloxamer, Hydroxy Propyl Methyl cellulose g

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Özakın, Süleyman. "pH effect on paraben stability for parenteral drug formulation." Journal of Research in Pharmacy 29, no. 1 (2025): 280–86. https://doi.org/10.12991/jrespharm.1643757.

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The pH optimization and EDTA are widely used in pharmaceutical formulations. The aim of the research work was to evaluate the pH effect and develop a including stable paraben pharmaceutical product. pH of final product is most important critical quality attributes (CQA). Variability pH of formulation is affecting paraben stability. Therefore, chemical stability may affect paraben assay, so this CQA was be evaluated throughout parenteral formulation. A total of four formulations were designed to the stability study. To improve the stability of paraben formulations (T1-T4) were evaluated with di

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Khobragade, Deepak S., K. Vighneshwar, and Mrunali S. Potbhare. "Development and Evaluation of Novel Multi-unit Pellet System Formulation of Metoprolol Succinate for Extended Release." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1219–27. http://dx.doi.org/10.25258/ijddt.12.3.49.

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Metaprolol succinate is a highly water-soluble drug with extensive first-pass metabolism. It needs to be administered about 3-4 times a day for optimum therapeutic effect. Conventional extended-release formulations are available but have their own disadvantages. The study was to designed formulate and evaluate the prolonged-release compressed multiple-unit pellet system of Metoprolol succinate. MUPS are novel formulations with benefits of both single and multi unit dosage forms and can provide extended drug delivery release profile and increase the efficiency profile of the drug. Metaprolol su

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Tay, Erin, Tri-Hung Nguyen, Leigh Ford, et al. "Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure." Pharmaceutics 12, no. 1 (2019): 17. http://dx.doi.org/10.3390/pharmaceutics12010017.

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Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation. Isolation of ionizable drugs as low melting, lipophilic salts or ionic liquids (ILs) provides one means to enhance drug solubility in LBFs. However, whether different ILs benefit from formulation in different LBFs is largely unknown. In the current studies, lumefantrine was isolated as a number of different lipophilic salt/ionic liquid forms and performance was assessed after form

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Volitaki, Charitini, Andrew Lewis, Duncan Q. M. Craig, and Asma Buanz. "Electrospraying as a Means of Loading Itraconazole into Mesoporous Silica for Enhanced Dissolution." Pharmaceutics 16, no. 8 (2024): 1102. http://dx.doi.org/10.3390/pharmaceutics16081102.

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Mesoporous silica particles (MSPs) have been investigated as potential carriers to increase the apparent solubility and dissolution rate of poorly water-soluble drugs by physically stabilising the amorphous nature of the loaded drug. In preparing such systems, it is recognized that the loading method has a critical impact on the physical state and performance of the drug. To date, there has been very limited investigation into the use of electrospraying for loading drugs into mesoporous silica. In this study, we further explore the use of this approach, in particular as a means of producing am

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Kumar, Akepati Sravan, B. Jagadeesh Babu, B. Nageswara Naik, and M. Pradeep Kumar. "Formulation and evaluation of miconazole-loaded nanosponges for topical delivery." International Journal of Experimental and Biomedical Research 4, no. 1 (2025): 16–25. https://doi.org/10.26452/ijebr.v4i1.701.

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In this work, nanosponges were made by solvent evaporation and mixed with miconazole to form a gel. Utilizing the solvent evaporation method, the formulations for the Nanosponges were created with PVA functioning as a co-polymer and rate-retarders HP-? Cyclodextrin and HPMC K4M. FTIR (Fourier Transform Infra-Red) spectroscopy was employed to ascertain the drug's compatibility with those in the formulation. We examined the surface form, yield of manufacture, and efficacy of drug entrapment in nanosponges. The Nanosponges' shape and surface morphology were investigated using scanning electron mi

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Vadgama, Vishalkumar K., and Vishal L. Gaekwad. "Cost minimization analysis of generic and innovator formulations of antihypertensive drugs." International Journal of Basic & Clinical Pharmacology 8, no. 12 (2019): 2625. http://dx.doi.org/10.18203/2319-2003.ijbcp20195268.

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Background: Hypertension, a chronic condition requiring lifelong care, affects approximately 25.3% Indian population. Average annual hypertension management cost which also includes medication cost varies from Rs. 4042 to 7621, amounting up to 40% of total household income of few families. Selection of a different brand or generic formulation may have an immense impact on total expenditure for treatment of hypertension. Present study aims at determining cost variability and cost analysis of various single drug antihypertensive formulations available in Indian market.Methods: One most prescribe

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Ansari, Mojabir Hussen. "Preclinical Drug Development Process: Formulation and Development Aspects." International Journal of Medical & Pharmaceutical Sciences 13, no. 03 (2023): 01–10. http://dx.doi.org/10.31782/ijmps.2023.13301.

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Drug discovery and development process aims to make available new pharmacological entities to prevent, treat, mitigate or cure disease in a safe and effective manner. It involves rigorous testing and optimization of selected compounds to identify the drug that is most effective. Drug development starts with a target identification and validation, followed by drug candidate (hits) discovery, and lead drug (compound with favourable pharmaceutical, safety, efficacy and pharmacokinetic profile) selection and optimization then preclinical research, clinical research, FDA drug review, FDA post-marke

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Agubata, Chukwuma. "Self-Emulsifying Formulations: A Pharmaceutical Review." Journal of Drug Delivery and Therapeutics 10, no. 3 (2020): 231–40. http://dx.doi.org/10.22270/jddt.v10i3.3981.

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The oral route of drug delivery is commonly utilized for administration of medicines and is particularly preferred for the treatment of many chronic diseases which require continuous ingestion over a reasonably prolonged period of time. However the oral delivery of lipophilic drugs presents a major obstacle because of their low aqueous solubility. The aqueous solubility of a drug is a crucial determinant of its dissolution rate, absorption and bioavailability. Drugs with relatively high intrinsic lipophilicity can be dissolved in appropriate mixtures of oils/lipids, surfactants, cosolvents whi

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Gupta, Nitin, Giriraj T. Kulkarni, Pravin Kumar, and Rajendra Awasthi. "Grewia asiatica Mucilage: A Smart Gelling Polymeric Material for Pharmaceutical Applications In Vitro Studies." Current Materials Science 12, no. 2 (2020): 117–26. http://dx.doi.org/10.2174/2666145412666191125124644.

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Background: Natural plant-based materials have several advantages. They are biodegradable, biocompatible, non-toxic, cost-effective, environment friendly, easily available, and can undergo chemical modification. Objective: Grewia asiatica extracts contain various phytoconstituents and have therapeutic benefits such as antimicrobial and anti-diabetic properties. They form colloidal dispersions and make a highly viscous gel in water. Considering these properties of Grewia asiatica mucilage, the present work was aimed to investigate its application in the formulation of gel for the topical delive

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Moribe, Kunikazu, Waree Limwikrant, Kenjirou Higashi, and Keiji Yamamoto. "Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives." Journal of Drug Delivery 2011 (April 26, 2011): 1–9. http://dx.doi.org/10.1155/2011/138929.

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Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients. In addition to drug solubilization, drug nanoparticle formation was observed using ascorbyl glycoside. Hydrophobic ascorbic acid derivatives such as ascorbyl mono- and di-n-alkyl fatty acid derivatives are used either as drugs or carrier components. Ascorbyl n-alkyl fatty acid derivatives have been formulated as antioxidants or

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Miyamoto, Kahori, Tomomi Akita, and Chikamasa Yamashita. "Radiolabeling Method for Lyophilizate for Dry Powder Inhalation Formulations." Pharmaceutics 14, no. 4 (2022): 759. http://dx.doi.org/10.3390/pharmaceutics14040759.

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Human lung deposition data is non-mandatory for drug approval but very useful for the development of orally inhaled drug products. Lung deposition of inhaled drugs can be quantified by radionuclide imaging, for which one of the first considerations is the method used to radiolabel formulations. In this study, we report the development of a radiolabeling method for lyophilizate for dry powder inhalation (LDPI) formulations. TechneCoatTM is one method that can radiolabel drug particles without using solvents. In this method, particles are radiolabeled with a dispersion of 99mTc-labeled nanoparti

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Pallavi, T., G. S. Sharma, B. Rama, L. Jyothi Rani, and B. Rajkamal. "Formulation and evaluation of floating bilayer tablets of epleronone." World Journal of Pharmaceutical Sciences 10, no. 04 (2022): 08–17. http://dx.doi.org/10.54037/wjps.2022.100402.

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Gastro retentive drug delivery systems have been widely used to prolong retention of dosage forms in stomach. Among the various approaches, the floating bilayer tablets formulation offers sustained drug release as well as prolonged gastric retention, along with the added advantage of liquid oral dosage form. The present study was an attempt to formulate and evaluate floating bilayer tablets of Epleronone by using various polymers like guar gum, ethyl cellulose, SSG, CCS. The prepared floating Bilayered tablets were evaluated for hardness, Weight variation, thickness, friability, drug content u

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