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Journal articles on the topic 'And Nanocochleates'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Harwalkar Mallappa S, Salunkhe Kishor S, Chintamani Ravindra B, and Raosaheb Sopanrao S. "Formulation and Evaluation of Lyophilized Nanocochleates of Paclitaxel – For Cancer Chemotherapy." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 2884–94. http://dx.doi.org/10.26452/ijrps.v11i3.2369.

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The nanocochleates are mainly prepared from the liposomes of active pharmaceutical ingredients (APIs) with the help of inactive ingredients like phosphatidylserine (PS) and calcium. The PS shows a considerable binding affinity towards calcium mainly due to the calcium’s tendency to lose part of its hydration shell and to displace water upon complexation. Due to neutralization of the electrostatic charge, calcium causes aggregation & fusion of liposomes composed PS with each other. It has been reported that ca++ has an affinity to form a more tightly packed & highly ordered and less hyd

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2

Samruddhi, More* Prajakta Kangutkar Shital Kamble Dr. D. R. Jadage. "Nanocochleates As a Novel Lipid-Based Nano Carrier for Enhanced Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1535–44. https://doi.org/10.5281/zenodo.15380480.

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As a type of lipid-based nanocarrier, nanocochleates have demonstrated great promise in improving drug delivery. They are made up of lipid bilayers that are rolled up into a cochleate structure, which provides a unique platform for encapsulating drugs. It has been demonstrated that nanocochleates improve drug stability, target specific tissues or cells, and provide controlled release of drugs. Because of their lipid-based composition, which makes them biocompatible and biodegradable, the use of nanocochleates for drug delivery has several benefits, such as increased efficacy, decreased side ef

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Kesharwani, Anubhav* Pandey Prince Ram Vishal. "Nanocochleates: A Novel Platform in Delivery Therapeutic Cargo." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3350–57. https://doi.org/10.5281/zenodo.15471652.

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This review article explores the exciting potential of nanocochleates as a novel drug delivery platform. Lipid-based drug delivery (LDDs) systems attract increasing interest in the pharmaceutical industry due to their advantages in solubility and bioavailability of poorly water-soluble drugs. Nanocochleates are the lipid based multi-layered spiral structure that resemble a small shell-like structure which is achieved through the interaction of negatively charged lipid and positively charged calcium ions which causes lipid bilayer to roll into cochlear-like structure. Due to these structures na

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Katoriya, V. S., G. S. Deokar, and S. J. Kshirsagar. "IONOTROPIC TRAPPING LECITHIN BASED CILOSTAZOL NANOCOCHLEATES FOR DRUG DELIVERY APPLICATIONS." INDIAN DRUGS 54, no. 09 (2017): 24–32. http://dx.doi.org/10.53879/id.54.09.10682.

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The nanocochleate drug delivery is based on encapsulating drugs in multilayered lipid crystal matrix (a cochleate) to potentially deliver the drug safely and effectively through the lipoidal membrane. Cilostazol is approved for the treatment of intermittent claudication and used as fibrinolytic agent, platelet aggregation inhibitor, bronchodilator agent, phosphodiesterase III Inhibitor and vasodilator agent. therefore, this drug delivery is suitable to deliver drug molecules into blood vessels. Formulations with lecithin showed good in vitro drug release, drug entrapment study results and the

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Sardar, Shelake* Aishwarya Ingrole Dr. Nilesh chougule. "Preparation Optimization And Evaluation Of Lenvatinib As A Nanocochleats." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 2136–42. https://doi.org/10.5281/zenodo.13131860.

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The objective of developing nanocochleates was to enhance drug bioavailability by improving solubility. Preformulation studies identified the drug and excipients through physical analysis methods. The drug's maximum wavelength was 254 nm in phosphate buffer pH 6.8, and 249 nm in methanol. Initially, liposomes were formed using the thin film hydration method, adjusting the cholesterol and lipid ratio. Subsequently, nanocochleates were produced using a trapping method. The formulation was optimized by considering the rotary evaporator speed, solvent system ratio and volume, hydration media pH, p

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GR1, Godge. "An Overview of Nanocochleates for Improving Oral Absorption Using a Phospolipid-Based Drug Delivery System." Bioequivalence & Bioavailability International Journal 8, no. 2 (2024): 1–11. http://dx.doi.org/10.23880/beba-16000236.

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A novel approach to oral and systemic drug delivery is nanaocochleate. It is a brand-new lipid-based system that offers a distinct technological platform appropriate for the systemic and oral delivery of numerous compounds with significant biologically therapeutic properties, such as medications, genes, and vaccine antigens. The technology of nanocochleate formulation is especially useful for hydrophobic macromolecules and small molecules with low oral bioavailability, as well as those that are negatively or positively charged. Research on the proof-of-principle of cochleate-mediated oral deli

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Vajir, Shaikh* Dipak Bade Anuradha Salunkhe Pravin Patil Omkar Bhagat Ajinkya Nalawade Shivanjali Shelake. "An Overview of Nanocochleates for Improving Oral Absorption of Antifungal Drugs Using a Phospolipid-Based Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2387–98. https://doi.org/10.5281/zenodo.15421913.

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Nanaocochleate is a unique method of systemic and oral medication delivery. It is a novel lipid-based system that provides a unique technical platform suitable for the oral and systemic delivery of several substances with important medically therapeutic qualities, including genes, vaccine antigens, and pharmaceuticals. Hydrophobic macromolecules, tiny compounds with low oral bioavailability, and negatively or positively charged molecules are particularly well-suited for the technique of nanocochleate formulation. Clinically relevant, well-established medications that are now only provided by i

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Tilawat, Meena, and Smita Bonde. "Nanocochleates: A potential drug delivery system." Journal of Molecular Liquids 334 (July 2021): 116115. http://dx.doi.org/10.1016/j.molliq.2021.116115.

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9

Munot, Neha, Ujjwala Kandekar, Prabhanjan S. Giram, Kavita Khot, Abhinandan Patil, and Simona Cavalu. "A Comparative Study of Quercetin-Loaded Nanocochleates and Liposomes: Formulation, Characterization, Assessment of Degradation and In Vitro Anticancer Potential." Pharmaceutics 14, no. 8 (2022): 1601. http://dx.doi.org/10.3390/pharmaceutics14081601.

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Quercetin, a flavonoid, has antioxidant and anti-inflammatory properties and the potential to inhibit the proliferation of cancer, but its therapeutic efficacy is lowered due to poor solubility and bioavailability. Quercetin-loaded nanocochleates (QN) were developed using a trapping method by the addition of calcium ions into preformed negatively charged liposomes (QL) prepared by a thin-film hydration method. Liposomes were optimized by varying the concentration of Dimyristoyl phosphatidyl glycerol and quercetin by applying D-optimal factorial design using Design-Expert® software. Stable rods

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10

VP, Rawal, and Gangurde SA. "Study of Nootropic Effect of Improved Nano Formulation Version of Levodopa in a Rat Model of Parkinson’s Disease Induced by 6-Hydroxydopamine." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1560–65. http://dx.doi.org/10.25258/ijddt.14.3.43.

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Background: More studies on Parkinson’s disease (PD) symptoms have demonstrated that the condition is multifaceted. PD is associated with cognitive problems & motor impairments, which lower quality of life. 6-hydroxydopamine is a common rodent Parkinsonism neurotoxin. 6-OHDA may damage neurons by increasing oxidative stress from hydroxyl radical production during autoxidation. 6-OHDA and oxidative stress have been shown to impair memory in rats. Thus, 6-OHDA mimics rat Parkinsonian and cognitive decline. Objective: To construct a stable and easily administered nano-formulation with enhance

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11

Suresh, Kaviya, Devasena Srinivasan, Venkatesan Palanivel, and Anbarasan Balu. "Nanocochleates: Versatile Nanostructures for Enhanced Drug Delivery and Therapeutics." International Journal of Pharmaceutical Investigation 15, no. 1 (2024): 49–56. https://doi.org/10.5530/ijpi.20250082.

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12

Bhosale, Rohit R., H. V. Gangadharappa, D. V. Gowda, Riyaz Ali M. Osmani, and Rudra Vaghela. "A Review on Nanocochleates: The Inimitable Nanoparticulate Drug Carriers." Advanced Science, Engineering and Medicine 9, no. 5 (2017): 359–69. http://dx.doi.org/10.1166/asem.2017.2020.

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13

Vakhare, Aparna Gajanan, Vikrant P. Vankhade, Sandip C. Atram, Nishan N. Bobade, and Shrikant D. Pande. "Formulation and Evaluation of Liposomal Based Nanocochleate." Asian Journal of Pharmaceutical Research and Development 12, no. 4 (2024): 6–19. http://dx.doi.org/10.22270/ajprd.v12i4.1435.

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Rivastigmine is a parasympathomimetics and a reversible cholinesterase inhibitor. It inhibits both acetylcholinesterase and butylcholinesterase. It is used to treat mild to moderate dementia caused by Alzheimer's or Parkinson's disease. However, its bioavailability is about 36% due to hepatic first-pass metabolism. The plasma half-life of rivastigmine is approximately 1.5 hours. Rivastigmine tartrate-loaded nanococclets (RN) were developed using a trapping method by addition of calcium ions to preformed negatively charged liposomes (RL) prepared by thin film hydration method. Liposomes were op

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14

Machín, Laura, Beatriz Tamargo, Abel Piñón, et al. "Bixa orellana L. (Bixaceae) and Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae) Essential Oils Formulated in Nanocochleates against Leishmania amazonensis." Molecules 24, no. 23 (2019): 4222. http://dx.doi.org/10.3390/molecules24234222.

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Leishmaniasis is a group of neglected tropical diseases caused by protozoan parasites of the Leishmania genus. The absence of effective vaccines and the limitations of current treatments make the search for effective therapies a real need. Different plant-derived essential oils (EOs) have shown antileishmanial effects, in particular from Bixa orellana L. (EO-Bo) and Dysphania ambrosioides (L.) Mosyakin & Clemants (EO-Da). In the present study, the EO-Bo and EO-Da, formulated in nanocochleates (EO-Bo-NC and EO-Da-NC, respectively), were evaluated in vitro and in vivo against L. amazonensis.

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15

Zhong, Xiaoming, Bin Chen, and Zhiwen Yang. "Nanocochleates as the Potential Delivery Systems for Oral Antitumor of Hydroxycamptothecin." Journal of Biomedical Nanotechnology 14, no. 7 (2018): 1339–46. http://dx.doi.org/10.1166/jbn.2018.2572.

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16

Verekar, Rucheera, Sharvari Dessai, Muniappan Ayyanar, Sameer Nadaf, and Shailendra Gurav. "Nanocochleates: Revolutionizing lipid-based drug delivery with enhanced bioavailability, a review." Hybrid Advances 6 (August 2024): 100215. http://dx.doi.org/10.1016/j.hybadv.2024.100215.

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17

Asprea, Martina, Francesca Tatini, Vieri Piazzini, Francesca Rossi, Maria Bergonzi, and Anna Bilia. "Stable, Monodisperse, and Highly Cell-Permeating Nanocochleates from Natural Soy Lecithin Liposomes." Pharmaceutics 11, no. 1 (2019): 34. http://dx.doi.org/10.3390/pharmaceutics11010034.

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(1) Background: Andrographolide (AN), the main diterpenoid constituent of Andrographis paniculata, has a wide spectrum of biological activities. The aim of this study was the development of nanocochleates (NCs) loaded with AN and based on phosphatidylserine (PS) or phosphatidylcholine (PC), cholesterol and calcium ions in order to overcome AN low water solubility, its instability under alkaline conditions and its rapid metabolism in the intestine. (2) Methods: The AN-loaded NCs (AN–NCs) were physically and chemically characterised. The in vitro gastrointestinal stability and biocompatibility o

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18

Bothiraja, Chellampillai, Bhagwat D. Yojana, Atmaram P. Pawar, Karimunnisa S. Shaikh, and Uday H. Thorat. "Fisetin-loaded nanocochleates: formulation, characterisation,in vitroanticancer testing, bioavailability and biodistribution study." Expert Opinion on Drug Delivery 11, no. 1 (2013): 17–29. http://dx.doi.org/10.1517/17425247.2013.860131.

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19

Poudel, Ishwor, Raj Ahiwale, Atmaram Pawar, Kakasaheb Mahadik, and C. Bothiraja. "Development of novel biotinylated chitosan-decorated docetaxel-loaded nanocochleates for breast cancer targeting." Artificial Cells, Nanomedicine, and Biotechnology 46, sup2 (2018): 229–40. http://dx.doi.org/10.1080/21691401.2018.1453831.

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20

Tamargo Santos, Beatriz, Catherine Fleitas Pérez, Juan F. Infante Bourzac, et al. "Remote induction of cellular immune response in mice by anti-meningococcal nanocochleates - nanoproteoliposomes." Science of The Total Environment 668 (June 2019): 1055–63. http://dx.doi.org/10.1016/j.scitotenv.2019.03.075.

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21

Bothiraja, C., Neeti Rajput, Ishwor Poudel, S. Rajalakshmi, Bijoy Panda, and Atmaram Pawar. "Development of novel biofunctionalized chitosan decorated nanocochleates as a cancer targeted drug delivery platform." Artificial Cells, Nanomedicine, and Biotechnology 46, sup1 (2018): 447–61. http://dx.doi.org/10.1080/21691401.2018.1430584.

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22

Tilawat, Meena, and Smita Bonde. "Curcumin and quercetin loaded nanocochleates gel formulation for localized application in breast cancer therapy." Heliyon 9, no. 12 (2023): e22892. http://dx.doi.org/10.1016/j.heliyon.2023.e22892.

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23

Asprea, Martina, Isabella Leto, Maria Camilla Bergonzi, and Anna Rita Bilia. "Thyme essential oil loaded in nanocochleates: Encapsulation efficiency, in vitro release study and antioxidant activity." LWT 77 (April 2017): 497–502. http://dx.doi.org/10.1016/j.lwt.2016.12.006.

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24

Shanmugam, Thanigaivel, Nitin Joshi, Nadim Ahamad, Atul Deshmukh, and Rinti Banerjee. "Enhanced absorption, and efficacy of oral self-assembled paclitaxel nanocochleates in multi-drug resistant colon cancer." International Journal of Pharmaceutics 586 (August 2020): 119482. http://dx.doi.org/10.1016/j.ijpharm.2020.119482.

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25

Yücel, Çiğdem, Yeşim Altintaş, Zelihagül Değim, et al. "Novel Approach to the Treatment of Diabetes: Embryonic Stem Cell and Insulin-Loaded Liposomes and Nanocochleates." Journal of Nanoscience and Nanotechnology 19, no. 7 (2019): 3706–19. http://dx.doi.org/10.1166/jnn.2019.16321.

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26

Nadaf, Sameer, and Suresh Killedar. "Development and Validation of RP–HPLC Method for Estimation of Curcumin from Nanocochleates and Its Application in in–vivo Pharmacokinetic Study." Acta Chimica Slovenica 67, no. 4 (2020): 110–1110. http://dx.doi.org/10.17344/acsi.2020.5892.

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A reliable RP-HPLC analytical method with UV detection at 421 nm was developed and validated for the quantitative determination of curcumin from rat plasma after oral administration of curcumin loaded nanocochleates (CU-NC) to rats. The chromatographic separation was performed on HIQ SIL, C18 (250 mm × 4.6 mm) column using methanol and water (80:20 v/v) as mobile phase, at 1.0 mL/min flow rate. Validation parameters included linearity, accuracy, precision, and limit of quantitation and detection. Good linearity was obtained over the range of 2.5–100 μg/mL (R2 = 0.9979) of curcumin. The develop

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Kumar, Rachna M., Hitesh Kumar, Tanvi Bhatt, et al. "Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics." Pharmaceuticals 16, no. 2 (2023): 196. http://dx.doi.org/10.3390/ph16020196.

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Cancer is one of the major causes of mortality, globally. Cancerous cells invade normal cells and metastasize to distant sites with the help of the lymphatic system. There are several mechanisms involved in the development and progression of cancer. Several treatment strategies including the use of phytoconstituents have evolved and been practiced for better therapeutic outcomes against cancer. Fisetin is one such naturally derived flavone that offers numerous pharmacological benefits, i.e., antioxidant, anti-inflammatory, antiangiogenic, and anticancer properties. It inhibits the rapid growth

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Lipa Castro, Antonio, Sébastien Pomel, Catherine Cailleau, et al. "Pharmacokinetics, biodistribution, and activity of Amphotericin B-loaded nanocochleates on the Leishmania donovani murine visceral leishmaniasis model." International Journal of Pharmaceutics 624 (August 2022): 121985. http://dx.doi.org/10.1016/j.ijpharm.2022.121985.

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El-Melegy, Mohamed G., Hoda M. Eltaher, Ahmed Gaballah, and Amal H. El-Kamel. "Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal." European Journal of Pharmaceutics and Biopharmaceutics 168 (November 2021): 166–83. http://dx.doi.org/10.1016/j.ejpb.2021.08.020.

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30

Pham, T. T. H., G. Barratt, J. P. Michel, P. M. Loiseau, and M. Saint-Pierre-Chazalet. "Interactions of antileishmanial drugs with monolayers of lipids used in the development of amphotericin B–miltefosine-loaded nanocochleates." Colloids and Surfaces B: Biointerfaces 106 (June 2013): 224–33. http://dx.doi.org/10.1016/j.colsurfb.2013.01.041.

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31

Tamargo, Beatriz, Lianet Monzote, Abel Piñón, et al. "In Vitro and In Vivo Evaluation of Essential Oil from Artemisia absinthium L. Formulated in Nanocochleates against Cutaneous Leishmaniasis." Medicines 4, no. 2 (2017): 38. http://dx.doi.org/10.3390/medicines4020038.

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Shapira, Iuliana, Daniel R. Budman, Thomas Bradley, and Richard Gralla. "Evolving lipid-based delivery systems in the management of neoplastic disease." Oncology Reviews 2, no. 2 (2011): 113. http://dx.doi.org/10.4081/oncol.2009.113.

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Drug delivery systems for the therapeutic use of cytotoxic chemotherapy are an essential aspect of successful treatment and remain under active evaluation. Such systems offer advantages such as they can change the pharmacologic and pharmacodynamic properties of an active drug in preclinical screens to meet the needs of therapy in humans. For example, unstable or insoluble agents can be formulated in a manner to allow effective exposure in the tumor. Liposomal delivery systems are the most mature with regulatory approval for several liposomal preparations. The liposome is attractive as the char

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Silva, Vitória Regina Pereira da, Natália Ornelas Martins, Carolina Ramos dos Santos, et al. "Annatto (Bixa orellana)-Based Nanostructures for Biomedical Applications—A Systematic Review." Pharmaceutics 16, no. 10 (2024): 1275. http://dx.doi.org/10.3390/pharmaceutics16101275.

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Plants are a source of valuable organic chemical compounds with complex structures rich in therapeutic activities. The encapsulation of compounds in nanostructured systems is an alternative to avoid limitations, such as instability and low solubility, and to promote therapeutic use. The objective of the present review was to summarize the data in the literature on the physicochemical characteristics, biomedical efficacy, and toxicity of nanostructures containing extracts and oils obtained from annatto (Bixa orellana). For this, searches were conducted in the CINAHL, LILACS, Embase, FSTA, MEDLI

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Tamargo, S. B., T. Bui Thanh, M. Pérez, et al. "Nanocochleates containing N-Octylglicoside extracted Vibrio cholerae antigens elicited high vibriocidal antibodies titers after intragastric immunization in a mice model." Microbial Pathogenesis 156 (July 2021): 104902. http://dx.doi.org/10.1016/j.micpath.2021.104902.

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35

Nadaf, Sameer J., and Suresh G. Killedar. "Curcumin nanocochleates: Use of design of experiments, solid state characterization, in vitro apoptosis and cytotoxicity against breast cancer MCF-7 cells." Journal of Drug Delivery Science and Technology 47 (October 2018): 337–50. http://dx.doi.org/10.1016/j.jddst.2018.06.026.

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Nadaf, Sameer J., and Suresh G. Killedar. "Nanoliposome Precursors for Shape Modulation: Use of Heuristic Algorithm and QBD Principles for Encapsulating Phytochemicals." Current Drug Delivery 17, no. 7 (2020): 599–612. http://dx.doi.org/10.2174/1567201817666200512102532.

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Background: Screening of multiple methods is worthless for formulators due to material losses, wastage of time, and expenditures. It is imperative to make a quick decision. Objective: The present investigation describes the systematic approach to select the best suitable method for the development of nanoliposomes (NL), the precursor of nanocochleates encapsulating curcumin using Analytic Hierarchy Process (AHP). Methods: Pair-wise comparison matrices were used to achieve the overall priority weight and ranking for the selection of appropriate technique. Furthermore, Plackett-Burman screening

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Molaveisi, Mohammad, Ya Zhao, Li Li, and Qilong Shi. "Co-delivery of phycocyanin and astaxanthin using nanocochleates as a novel delivery vehicle: Effects of pigment concentration on physicochemical, structural, and in vitro digestion properties." Journal of Food Engineering 403 (January 2026): 112746. https://doi.org/10.1016/j.jfoodeng.2025.112746.

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Wakchaure, Snehal M., and Manjusha P. Mhaske. "Nanocochleate: A review." World Journal of Pharmaceutical Sciences 09, no. 11 (2021): 87–94. http://dx.doi.org/10.54037/wjps.2021.91105.

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Bilia, Anna Rita, Vieri Piazzini, Martina Asprea, Laura Risaliti, Giulia Vanti, and Maria Camilla Bergonzi. "Plants Extracts Loaded in Nanocarriers: An Emergent Formulating Approach." Natural Product Communications 13, no. 9 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300914.

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Over the millennia, plants have represented for Humankind the main source of food, but also a vast resource to maintain health, for prophylactic properties or to cure human and animal diseases. Presently, between 65 and 80% of populations in developing countries use medicinal plants as therapeutic remedies for their primary healthcare and in Europe and USA there is an increasing demand of botanical products both on the form of food supplements and herbal medicinal products. Botanicals on the market are mainly based on traditional (infusions or decoctions), conventional (using organic solvents)

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Eskandarynasab, Maryam, Shahroo Etemad-Moghadam, Mojgan Alaeddini, et al. "Novel osteoprotective nanocochleate formulation: A dual combination therapy-codelivery system against glucocorticoid induced osteoporosis." Nanomedicine: Nanotechnology, Biology and Medicine 29 (October 2020): 102273. http://dx.doi.org/10.1016/j.nano.2020.102273.

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41

Campo, Silvia, Brunilde Arseni, Stefania Rossi, et al. "Efficacy of a Nanocochleate-Encapsulated 3,5-Diaryl-s-Triazole Derivative in a Murine Model of Graft-Versus-Host Disease." Transplantation 86, no. 1 (2008): 171–75. http://dx.doi.org/10.1097/tp.0b013e31817ba761.

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NAYEK, SUJIT, ABHIRAMI VENKATACHALAM, and SANGEETA CHOUDHURY. "RECENT NANOCOCHLEATE DRUG DELIVERY SYSTEM FOR CANCER TREATMENT: A REVIEW." International Journal of Current Pharmaceutical Research, November 15, 2019, 28–32. http://dx.doi.org/10.22159/ijcpr.2019v11i6.36359.

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Nanocochleates are at the forefront of the fast-growing nanotechnology sector in the delivery of drugs for cancer. This nanotechnology is the use of the cationic and anionic encapsulated drug that has poor oral bioavailability. Nanocochleate is a lipid-based drug delivery in the liposomal vesicles that is converted by calcium divalent cation into nanocochleate. Nanocochleates technology use encapsulations of the anticancer agent, which have low solubility, oral bioavailability and low permeability. This paper shows and provides an overview of the benefits of nanocochleates, drug delivery mecha

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Dr., Meghana R. Babar Naveena. V. Vengala Juhi Singh. "SERRATIOPEPTIDASE LOADED NANOCOCHLEATE: NOVEL APPROACH FOR TRANSDERMAL DRUG DELIVERY SYATEM." September 28, 2020. https://doi.org/10.5281/zenodo.4056525.

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<em>Objective: Nanoochleates are tubular or cockle shaped structures derived from liposomes. Although investigated for several applications to be administered by oral and parenteral route, the potential of cochleates in topical drug delivery remains unexplored. The present study is a comprehensive report aimed at ascertaining the role of cochleates in topical delivery of drugs.Methods involved development and evaluation of lipoid S 75 based nanocochleate formulation of serratiopeptidase. A 2<sup>3</sup> factorial design was utilized to optimize nanocochleate formulation and to study effect of

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44

Mali, A. J., P. A. Joshi, C. Bothiraja, and A. P. Pawar. "Fabrication and application of dimyristoyl phosphatidylcholine biomaterial-based nanocochleates dry powder inhaler for controlled release resveratrol delivery." Future Journal of Pharmaceutical Sciences 7, no. 1 (2021). http://dx.doi.org/10.1186/s43094-021-00189-4.

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Abstract Background Resveratrol, a bioactive phytoconstituent, is used to treat chronic respiratory diseases. However, its clinical application was hampered due to its poor bioavailability. In the present study, controlled release of resveratrol loaded nanocochleate-based dry powder inhaler was investigated to improve its biopharmaceutical properties for pulmonary drug delivery. The in vivo toxicity study was performed in the healthy male albino Wistar rats by intracheal administration. Results Resveratrol loaded nanocochleate-based dry powder inhaler was prepared by lyophilizing the resveratr

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Sharma, Rahul, Ashwini Deshpande, and Abhishek Kanugo. "Formulation Optimization and Evaluation of Nanocochleate Gel of Famciclovir for the Treatment of Herpes Zoster." Recent Patents on Nanotechnology 16 (June 22, 2022). http://dx.doi.org/10.2174/1872210516666220622115553.

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Background: Herpes zoster is a viral infection triggered due to the reactivation of the varicella-zoster virus in the posterior dorsal root ganglion. Herpes zoster infections occur mostly in the facial, cervical and thoracic region of the body beginning with pain and resulted in the vesicular eruption. Recently, this infection is observed during the Covid-19 pandemic and also after the induction of mRNA-based vaccine for coronavirus at an extended level. Nanocochleates are cylindrical (cigar-shape) microstructure lipid-based versatile carriers for the drug delivery systems. Famciclovir is an a

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Rub, Rukhsana, Neha Munot, and Akshay Wadate. "Improved Efficacy and Stability of Silymarin Loaded Nanocochleates Over Liposomes for the Treatment of Skin Diseases." Journal of Pharmaceutical Research International, August 21, 2021, 163–76. http://dx.doi.org/10.9734/jpri/2021/v33i41b32355.

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Aim: Silymarin, a complex polyphenolic component mixture with anti-oxidant, anti-inflammatory, and membrane-stabilizing property is being investigated in several dermatological conditions. Present research aims to evaluate potential of silymarin loaded nanocochleates and liposomal topical application for treating chronic skin diseases. Study Design: Silymarin loaded liposomes and nanocochleates were formulated and optimized using Design Expert software. Different invitro and exvivo tests were performed to compare their performance. Place and Duration of Study: The study was conduct

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Bhosale, Rohit R., Dhanashri D. Chavan, and Bhagyesh U. Janugade. "Current Perspectives on Extensive Applications of Nanocochleates-based Drug Delivery." Current Nanomedicine 14 (May 28, 2024). http://dx.doi.org/10.2174/0124681873299928240516161243.

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Abstract: Enhancing therapeutic efficacy stands as a pivotal concern across various medical conditions. Traditional therapeutic approaches have encountered limitations in addressing numerous issues. Over the recent years, the integration of nanotechnology has successfully overcome these obstacles, ushering in a new era of advanced treatment modalities. One notable stride has been the utilization of lipid-based nanocarriers, which have demonstrated substantial improvements in therapeutic outcomes. Among these innovative drug delivery systems (lipid-based), nanocochleates have emerged as the foc

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Liu, Min, Xiaoming Zhong, and Zhiwen Yang. "Chitosan functionalized nanocochleates for enhanced oral absorption of cyclosporine A." Scientific Reports 7, no. 1 (2017). http://dx.doi.org/10.1038/srep41322.

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Abstract It remains a significant challenge to overcome the poor permeability of cyclosporine A and enhance its oral absorption. In this study, we have identified a positively charged chitosan that is able to induce coiling up of anionic lipids to form nanocochleates with an average size of 114.2 ± 0.8 nm, without the need for calcium ions. These functional chitosan-induced nanocochleates enhanced gastrointestinal absorption of cyclosporine A, up to a 3-fold increase in oral bioavailability. A fluorescence-labeling study confirmed that absorption mainly occurred in the duodenum and jejunum. Tr

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Srinivas, Dr Martha, Markad Pranali Sampat, Pawar Pratiksha Baburao, and Dr Vishal Bharat Babar. "A Novel Drug Delivery: Nanocochleates." International Journal of Pharmaceutical Sciences Review and Research 84, no. 6 (2024). http://dx.doi.org/10.47583/ijpsrr.2024.v84i06.012.

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Somnath, Gore Aarti, Gondkar Tejas Sandip, and Manjusha P. Mhaske. "Nanocochleate A Novel Drug Delivery System." Research Journal of Pharmaceutical Dosage Forms and Technology, March 10, 2025, 63–68. https://doi.org/10.52711/0975-4377.2025.00009.

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The current situation offers a variety of lipid-based nanocarrier technologies. Multi-layered cochleates stand out among these lipid-based nanocarriers as an innovative nanocarrier system for hydrophilic and hydrophobic medicines with enhanced drug permeability, stability, and dose reduction. Additionally, it aids in site-specific medication delivery with fewer side effects and increases the oral bioavailability of hydrophilic and hydrophobic medicines. There are numerous ways to create nanocochleates, and they can be utilized to deliver a wide range of active compounds for a wide range of app

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