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Dissertations / Theses on the topic 'And Rat aorta rings'

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Published: 14 March 2023

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1

Ghalb, Faraa Amer Ahmed. "IN VITRO FUNCTIONAL INTERPLAY BETWEEN PERIVASCULAR ADIPOSE TISSUE AND FLAVONOIDS: CRITICAL ROLE OF BETA3 RECEPTOR AND SUPEROXIDE ANION." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1207163.

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Flavonoids, a class of natural polyphenols abundantly present in our diet, have been shown to exert in vitro vasorelaxant activity. This was ascribed to a direct effect on the smooth muscle or factors released by the endothelium. Nowadays, perivascular adipose tissue (PVAT) is emerging as a fine regulator of blood vessel contractility. Therefore, it is conceivable to hypothesize that flavonoids vasoactivity may occur also through or is influenced, either positively or negatively, by PVATreleased factors. This hypothesis was assessed in vitro on rat aorta rings. Several flavonoids proved t

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2

Al-Zobaidy, Mohammed. "Differential actions of methlyarginines in the rat aorta." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3838/.

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The PhD project is about the Regulation of vascular tone by endothelium. It involves studying the effects of methylated arginine analogues such as monomethyl arginine (L-NMMA) and asymmetric dimethylarginine (ADMA) on nitric oxide (NO) activity in rat aorta using organ baths containing Krebs solution at 37 ˚C and gassed with 95% O2 and 5% CO2. These two inhibitors of endothelial nitric oxide synthase enzyme (eNOS) showed an anomalous action, as they inhibited basal NO activity (assessed by enhancement of phenylephrine-induced tone and by blocking relaxations produced by superoxide dismutase or

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3

藍志洪 and Chi-hung Nam. "Effect of cerivastatin on endothelial function in rat aorta." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B42575837.

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Nam, Chi-hung. "Effect of cerivastatin on endothelial function in rat aorta." Click to view the E-thesis via HKUTO, 2001. http://sunzi.lib.hku.hk/hkuto/record/B42575837.

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5

Vinh, Vu Huu. "Comparative contractile effects of halothane and sevoflurane in rat aorta." Kyoto University, 2001. http://hdl.handle.net/2433/150545.

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6

Gorp, Adrianus Wilhelmus van. "The relationship between structural and in vivo dynamic mechanical properties of the thoracic aorta in rats influence of ageing and hypertension /." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=7537.

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7

Rice, Kevin M. "Effects of aging on pressure-induced MAPK activation in the rat aorta." Huntington, WV : [Marshall University Libraries], 2005. http://www.marshall.edu/etd/descript.asp?ref=526.

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8

管漢偉 and Hon-wai Michael Koon. "Potentiating effects of platelet activating factor on endothelin-1 induced rat arota vasoconstriction." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31221014.

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9

Koon, Hon-wai Michael. "Potentiating effects of platelet activating factor on endothelin-1 induced rat arota vasoconstriction /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20565689.

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10

Ferreira, Iolanda João Mora Cruz de Freitas. "Pre and postjunctional effects of rosiglitazone on the isolated rat aorta and heart." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/61097.

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Ferreira, Iolanda João Mora Cruz de Freitas. "Pre and postjunctional effects of rosiglitazone on the isolated rat aorta and heart." Dissertação, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/61097.

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12

Li, Min. "Constrictor prostanoid-potentiated vascular contraction: regulation of endothelial and vascular smooth muscle mechanism by estrogen." Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/549.

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The objectives of this research were to elucidate the involvement of constrictor prostanoids in the vascular reactivity to vasopressin (VP) and the role of estrogen in the regulation of the constrictor prostanoid mechanism in the female rat. Aortas obtained from male, intact (InT)-, ovariectomized (OvX)- and OvX + estrogen-replaced (OvX+Est)-female rats were studied. Contractile responses to VP were examined in the presence of nonselective and selective cyclooxygenase (COX) inhibitors. Basal and VP-stimulated release of thromboxane A2 (TxA2) and prostacyclin (PGI2) from the aortic wall were m

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13

Manio, Michael Magtoto. "In vivo exposure to lipopolysaccharide unmasks contractions to the alpha2-adrenergic agonist dexmedetomidine in the rat aorta." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208015.

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Dexmedetomidine is α2-adrenergic agent and commonly used in the intensive care setting. It is used primarily to sedate critically ill patients in various surgical, endoscopic and radiologic procedures. This medication gained superiority with other sedatives with a distinct advantage of less depression of the respiratory system. Although dexmedetomidine is often administered to septic patients, the vascular effect has not been fully studied in this clinical setting. In this thesis, rats were administered saline or bacterial lipopolysaccharide (LPS) 1, 10 and 20 mg/kg. Aortic rings were obtai

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14

Taylor, S. G. "The modulatory role of the vascular endothelium on spasmogenic and relaxant responses in rat aorta." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378822.

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15

Qu, Chen, and 屈晨. "Modulation of endothelium-dependent contractions by chronic inhibitionof nitric oxide synthase in the rat aorta." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290835.

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16

Little, Marie-Térèse E. "The ontogeny of acyl coenzyme A: cholesterol acyltransferase in rat liver, intestine, adipose tissue, and aorta." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29416.

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Epidemiological studies have shown that cholesterol is a major risk factor for the development of atherosclerosis. Since the atherosclerotic plaque develops over a long period interventions early in life may be of some benefit. In addition, it has been shown that the enzymes involved in cholesterol metabolism can be manipulated in early life. Therefore, studies of the developmental patterns of the key enzymes in cholesterol metabolism are of great importance. Acyl coenzyme A: cholesterol acyltransferase (ACAT) is the primary enzyme which catalyzes the conversion of free cholesterol to choleste

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17

Hussain, Monira Begum. "Characterisation of the #alpha#â†1-adrenoceptor subtypes in rat isolated aorta, mesenteric and pulmonary arteries." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286507.

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18

Qu, Chen. "Modulation of endothelium-dependent contractions by chronic inhibition of nitric oxide synthase in the rat aorta." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290835.

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19

Qu, Chen, та 屈晨. "The dual peroxisome proliferator-activated receptor α/[gamma] agonist Wy14643 improves endothelial function in the aorta of thespontaneously hypertensive rat". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46917561.

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20

Furutani, Hidekatsu. "Ca[2+] entry channels involved in contractions of rat aorta induced by endothelin-1, noradrenaline and vasopressin." Kyoto University, 2003. http://hdl.handle.net/2433/148772.

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21

Otto, Anne. "The protection of rosuvastatin and ramipril against the development of nitrate tolerance in the rat and mouse aorta." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210861.

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Organic nitrates, such as nitroglycerine (NTG), are widely used for their potent vasodilator capacity in the management of coronary artery disease and heart failure. Unfortunately, their beneficial effect is rapidly lost due to the development of nitrate tolerance, which is translated by an impaired vasorelaxation to NTG and an increased oxidative stress production. Although the mechanisms of the development of nitrate tolerance are still not fully elucidated, much interest has been focused in treating nitrate-receiving patients together with other drugs in order to overcome the development of

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22

Chrétien, Marc Laurent. "Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 (3-(5'-hydroxymethyl-2'furyl)-1-benzylindazole)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63282.pdf.

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23

Brawley, Lee. "Classical and atypical β-andrenoceptor subtypes mediating relaxation in rat isolated aorta : role of the endothelium/nitric oxide pathway". Thesis, Glasgow Caledonian University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313178.

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24

Baltzer, Wendy Irene. "The role of constrictor prostanoids in the development of aortic coarctation-induced hypertension in male and female rats." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/1525.

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Vascular reactivity to vasopressin and phenylephrine is potentiated by constrictor prostanoids (CP) in normotensive female (F) but not male (M) rat aorta and CP function is estrogen-dependent. This study investigated the effects of estrogen on CP function and arterial blood pressure (MAP) during development of aortic coarctation-induced hypertension (HT). M and F rats, (15-18 wks.) in four groups: normotensive (NT), hypertensive (HT), ovariectomized (OVX), and OVX estrogen-replaced (OE), underwent abdominal aortic coarctation or sham surgery (NT). At 14 days, SQ 29,548 (SQ, Thromboxane A2 (TXA

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25

MagalhÃes, Pedro Jorge Caldas. "Estudo farmacologico do Ãleo essencial do Croton nepetaefolius Baill sobre os musculos lisos traqueal e vascular e sobre as propriedades eletrofisiologicas de neuronios fasicos de ganglio celiaco." Universidade Federal do CearÃ, 2002. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=50.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Estudo farmacolÃgico do Ãleo essencial de Croton nepetaefolius Baill. sobre o mÃsculo liso traqueal e vascular e sobre as propriedades eletrofisiolÃgicas de neurÃnios fÃsicos de gÃnglio celÃaco. Pedro Jorge Caldas MagalhÃes, Tese de Doutorado em Farmacologia, UFC, 2002. Croton nepetaefolius Baill Ã um arbusto aromÃtico do Nordeste brasileiro, conhecido como âmarmeleiro sabiÃâ, utilizado na medicina popular como antiespasmÃdico e carminativo. Os principais con

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Zhang, Xiao-feng. "Pharmacological Characterization of Ca^<2+> entry channels in ET-1-induced contraction in rat aorta using LOE 908 and SK&F 96365." Kyoto University, 1999. http://hdl.handle.net/2433/181252.

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27

Olah, Mark E. "Effects of calcium channel blockade and intracellular calcium antagonism on endothelium-dependent responses of the isolated rat aorta and influence of the endothelium on drug action /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487590702989006.

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28

Monteiro, Fábio de Souza. "Ação relaxante da fração de alcaloides totais obtida de Solanum paludosum Moric. envolve modulação positiva da via do óxido nítrico e dos canais de K+ em íleo de cobaia e aorta de rato." Universidade Federal da Paraíba, 2013. http://tede.biblioteca.ufpb.br:8080/handle/tede/6772.

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Made available in DSpace on 2015-05-14T12:59:47Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2456836 bytes, checksum: 09d3f72dc7985812ae8e5dab865bed8c (MD5) Previous issue date: 2013-02-19<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Solanum paludosum Moric. (Solanaceae), popularly known as "jurubeba roxa" in Brazil Northeast, is used as a substitute for Solanum paniculatum ( jurubeba-verdadeira ) in folk medicine to treat hypertension and gastrointestinal disorder. In previous studies performed by Monteiro (2009) with total alkaloid fraction obtained from th

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Medeiros, Marcos Antônio Alves de. "Investigação do efeito vasorelaxante e caracterização eletrofisiológica dos alcalóides curina e reticulina." Universidade Federal da Paraíba, 2009. http://tede.biblioteca.ufpb.br:8080/handle/tede/6829.

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Made available in DSpace on 2015-05-14T13:00:06Z (GMT). No. of bitstreams: 1 parte1.pdf: 1450137 bytes, checksum: 1838bf2efddf0ca147f276df88417bb6 (MD5) Previous issue date: 2009-09-24<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>It was been demonstrated that curine and reticuline, induced a vasodilator effect in the rat small mesenteric arteries through inhibition of voltage-gated Ca2+ channels (VGCC). These compounds, curine and reticuline were isolated from the root barks of Chondrondendron platyphyllum and Ocotea duckei Vattimo, respectively, therefore

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30

Playl, Lauren A. "Sry Transcript Expression in Five Adult Male Rat Tissues and Correlation with Acsl3 Transcript Expression." University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1290632541.

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31

Vasconcelos, Flavio de. "Efeitos de a e b-neurotoxinas da peçonha do escorpião Tityus serrulatus sobre a liberação de catecolaminas, pressão arterial, captação de neurotransmissores e concentração de cálcio em células de músculo liso de aorta de ratos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-21052007-095139/.

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Toxinas que atuam em canais para Na+ operados por voltagem são as principais responsáveis pelos efeitos tóxicos do envenenamento escorpiônico e podem ser divididas em duas classes: a- e b-neurotoxinas. TsTX-V e TsTX-I da peçonha de Tityus serrulatus (TsV) são, respectivamente, exemplos destas toxinas. Neste trabalho, foram avaliados os efeitos da TsV e destas toxinas sobre a pressão arterial média (PAM) e liberação de catecolaminas em ratos conscientes e não imobilizados, previamente cateterizados, bem como a captação de GABA, dopamina (DA) e glutamato (Glu) em sinaptosomas isolados de cérebro

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32

Barros, Ana Rodrigues. "Tributyltin (TBT) effects at a vascular level." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16393.

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Mestrado em Toxicologia e Ecotoxicologia<br>Organotins are an important class man made organometallic compounds and tributyltin (TBT) is one of the most studied chemicals within this class. TBT is a potent endocrine disruptor being also considered as an obesogenic, immunotoxic and neurotoxic compound. Humans were exposed to this and other organotin compounds as a consequence of their widespread commercial applications including plastic stabilizers, catalytic agents and industrial biocides. Their utilization as catalytic agents in the production of silicones leads to the presence of thes

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Veras, Robson Cavalcante. "Participação da via do óxido nítrico na resposta relaxante induzida por E- cinamaldeído-oxima em artéria mesentérica superior isolada de rato." Universidade Federal da Paraíba, 2009. http://tede.biblioteca.ufpb.br:8080/handle/tede/6737.

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Made available in DSpace on 2015-05-14T12:59:37Z (GMT). No. of bitstreams: 1 parte1.pdf: 2125844 bytes, checksum: f5e0174d3679c5bce4f74af8ed1b3d4f (MD5) Previous issue date: 2009-08-30<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Decreased availability of NO in the vasculature promotes the progression of cardiovascular diseases and oximes represents a NO-donor group capable of to restore this defictIn rat superior mesenteric arterial rings, as non-aromatic oximes: diacetylmonoxime and dimetylglycone-oxime, as aromatic oximes: benzofenone-oxime, 4-Cl-benzofenone

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BOULANGER, SAUNIER CHANTAL. "Phosphorylation d'une proteine de 16 kda par la proteine kinase dependant de l'amp cyclique et par la proteine kinase c dans la membrane plasmique des myocytes d'aorte de rat." Strasbourg 1, 1986. http://www.theses.fr/1986STR13158.

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35

Barandier, Christine. "Potentiel thérapeutique du manganèse et de l'un de ses dérivés synthétiques sur le système cardiovasculaire." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10238.

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Le present travail qui s'inscrit dans le cadre general des etudes consacrees a la protection pharmacologique des tissus cardiaque et vasculaire au cours de la reperfusion post-ischemique, comprend deux parties principales. La premiere a ete realisee sur un modele d'ischemie/reperfusion myocardique sur un modele experimental de coeur isole de rat. Les resultats sont exprimes en termes de donnees fonctionnelles, metaboliques et ultrastructurales. La seconde partie est une etude pharmacologique menee sur un modele d'anneaux d'aorte isolee de rat et comporte essentiellement des mesures de contract

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36

Khelili, Smaïl. "Synthèse et étude pharmacologique d'activateurs de canaux K+/ATP dérivés des 1,2,4-benzothiadiazine-1,1-dioxydes." Grenoble 1, 1993. http://www.theses.fr/1993GRE10210.

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Le but de cette these est de synthetiser et d'etudier les proprietes pharmacologiques d'activateurs potassiques sensibles a l'atp. Ces activateurs derivent de la 1,2,4-benzothiadiazine-1,1-dioxyde qui comporte un reste sulfonyluree sur differentes positions de cet heterocycle. Dans la premiere partie, nous abordons les proprietes pharmacologiques des canaux potassiques et leur classification, ainsi que celles des composes les plus importants modulant ces canaux. En particulier, nous decrivons les 1,2,4-benzothiadiazine-1,1-dioxydes et les sulfonylurees, dont nous rappelons egalement les method

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Dantas, Bruna Priscilla Vasconcelos. "Participação dos canaisTRP nos efeitos cardiovasculares induzidos por carvacrol em ratos." Universidade Federal da Paraíba, 2010. http://tede.biblioteca.ufpb.br:8080/handle/tede/6854.

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Made available in DSpace on 2015-05-14T13:00:13Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2275378 bytes, checksum: fcb4196c739d83997818dc074daf738f (MD5) Previous issue date: 2010-03-11<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The pharmacological effects of carvacrol, a monoterpenoid phenol, on the cardiovascular system were studied in normotensive rats, using in vivo and in vitro techniques. In superior mesenteric artery rings isolated from rats with functional endothelium carvacrol (10-8 - 3 ₓ 10-4 M) concentration-dependently relaxed phenylephrine-i

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Cheng, Yu-Wen, and 鄭幼文. "Polycyclic aromatic hydrocarbons-induced vasorelaxation in rat aorta." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/52390419926054837039.

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博士<br>國立臺灣大學<br>毒理學研究所<br>87<br>The use of transporting vehicles has facilitated the improvement of human life since industrial revolution. However, the pollutant from the exhaust of vehicles have created a serious health problem especially in urban cities, including the cardiovascular diseases. For example, carbon monooxide, carbon dioxide and some polycyclic-aromatic hydrocarbons (PAHs), such as benzo(a)pyrene, dimethylbenzo(a)anthracene, and 3-methylchlorolanthracene, have been shown to induce artherosclerosis in animals. However, the studies concerning the effect of low-molecular weight po

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Tseng, Hsiang-Wen, and 曾湘文. "The Vasorelaxing Mechanisms of Rutamarin Alcohol in Rat Thoracic Aorta." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/94664114157860004755.

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碩士<br>國立陽明大學<br>藥理學研究所<br>89<br>Abstract We have examined both the hypotensive effect and the mechanisms of vasorelaxation of rutamarin alcohol (RA), a dihydrofuranocoumarins compound isolated from Ruta graveolens L. of Rutaceae. Intravenous bolus injections of RA (0.25-1.25 mg/kg) in anesthetized Sprage-Dawley rats produced dose-dependent hypotensive effects. In isolated rat thoracic aorta rings with or without endothelium, RA (10-7 ~ 10-4 M) relaxed phenylephrine (PE, 10-6M)- or KCl (60 mM)-induced vasocontractions. The vasorelaxing effect was greater for intact than for endot

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Novýsedláková, Alena. "The in vitro effects of selected isoflavonoids on isolated rat aorta." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-370988.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Alena Novýsedláková Supervisor: PharmDr. Jana Pourová, PhD. Title of Thesis: In vitro effects od selected isoflavonoids on isolated rat aorta Abstract: The aim of this study was to determine whether the selected isoflavonoids are able to vasodilate aorta, what structural features might be responsible for a relaxing activity and estimate the mechanism of action. The experiment we carried out the classical in vitro method on the isolated rat aorta, and the results evaluated by th

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Lin, Chung-Yin, and 林聰穎. "Synthesis and Vasorelaxant Activity of Naphthopyrans on Isolated Rat Thoracic Aorta." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/13148980448419198809.

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碩士<br>中國文化大學<br>應用化學研究所<br>88<br>Potassium channel openers, such as cromakalim, are potent smooth muscle relaxants which have been shown to have potential therapeutic application in a variety of cardiovascular and bronchopulmonary diseases, particularly in asthma, hypertension, and urinary incotinence. Cromakalim, the first benzopyran type potassium channel opener, was found as a potent antihypertensive agent in 1986. After that there have been numerous reports on modification of substituents at different positions of benzopyran ring, but few reports on modification of the benzopyran nucleus

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Ku, Tse-Cheng, and 顧澤承. "Vascular effects of Apocynum venetum leaf extract in rat thoracic aorta." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/92440536478474846608.

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碩士<br>中國醫藥大學<br>基礎醫學研究所碩士班<br>99<br>Abstract Apocynum venetum, also known as luobuma, has been used as the sole ingredient in antihypertensive tea in China. In our preliminary study, we found Apocynum venetum leaf extract (AVLE) could elicit vasorelaxation but at high dosage of AVLE could reverse the AVLE- evoked vasorelaxation. In this study, we investigate the vascular tension effect of this herb extract in isolated rat thoracic aorta. AVLE 10 µg/ml and carbachol (CCh) could elicit endothelium- dependent vasorelaxation. AVLE has shown the long-lasting vasodilatation which that effect could i

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趙俊迪. "Studies of The Vasodilating Effect of Berberine in Rat Denuded Aorta." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/28437504607721097696.

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碩士<br>高雄醫學大學<br>醫學研究所<br>82<br>Berberine, an alkaloid isolated from the Chinese herb Huanglian (the rhizome of Coptis Chinensis Franch) has been reported to have a vasodilating effect in rats and dogs. The vasodilating effect of berberine was assessed by adding phenylephrine (PE) or high potassium in the presence of various concentration of berberine. The effect of berberine on PE-sensitive Ca store was evaluated by adding PE to aorta in Ca-free solution. A7r5 smooth muscle cells with whole-cell patch clamp technique were used to study the effect of berberine on Ica, L of smooth muscle cell

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Huang, Tung-Yi, and 黃東益. "The Endothelial [Ca2+]i Signaling and Vascular Responsiveness in Rat Aorta In Situ." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/u9nv5a.

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博士<br>國立成功大學<br>基礎醫學研究所<br>90<br>Endothelial cells are heterogeneous in their surface receptors, signaling pathways, intrinsic genetic programs and physiological functions. Microvascular endothelium cultured from the brain, liver and other organs each expresses distinct patterns of cell surface markers, protein transporters, and intracellular enzymes. Many human vascular diseases are restricted to specific types of vessels. More and more evidence have shown that the preferential occurrences of vascular diseases might result from certain molecules expressed at particular endothelium. Althou

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Hsiao, Shih-Hao, and 蕭士豪. "Effects of Acrylamide on Isolated Rat Aorta and Mouse Phrenic-nerve Diaphragm Toxicity." Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107NCHU5252009%22.&searchmode=basic.

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碩士<br>國立中興大學<br>食品安全研究所<br>107<br>Purpose: Acrylamide (AA) can be formed during high-temperature frying or baking in the presence of both free asparagine and reducing sugars. It is known that AA displays genotoxicity, carcinogenicity, neurotoxicity and reproductive toxicity in laboratory animals. However, the related mechanisms of acrylamide-induced vasotoxicity and neuro-muscular toxicity are still unclear. This aim of this study was to investigate the possible mechanisms of vasotoxicity and neuro-muscular toxicity of acrylamide. Method: Vascular toxicity was studied by using an isolated rat

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Beránková, Anna. "Účinky vybraných látek in vitro na izolované aortě potkana." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380482.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Anna Beránková Supervisor: PharmDr. Jana Pourová, Ph.D. Title of diploma thesis: The in vitro effects of selected substances on isolated rat aorta Flavonoids are a numerous group of secondary plant metabolites. Flavonoid compounds are substances widely extended in nature and many of them have a positive influence on human health, primarily for their vasodilatory, antioxidant and anti- inflammatory effects. Three substances were selected for this diploma theses: two substances of isoflavono

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Chin, Trow-Wey, and 秦作威. "Transendothelial Transport of Low Density Lipoprotein (LDL) in Association with Cell Death in Rat Aorta." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/51704901055395896259.

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Hsun-HaoYeh та 葉訓豪. "Interleukin-1β-Induced Cellular Senescence of Vascular Smooth Muscle Cells Derived from Rat Abdominal Aorta". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/r9baw3.

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Sloukgi, Tatiana. "Účinky vybraných flavonolygnanů silymarinu ex vivo na izolované aortě potkana." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-412345.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Tatiana Sloukgi Supervisor: PharmDr. Jana Pourová, Ph.D. Title of Diploma Thesis: The effect of Silymarin Flavonolignans and their sulfated conjugates on blood vessels ex vivo. Silymarin flavonolignans have recently shown some positive effects on the cardiovascular system. In this work, we studied the vasodilatory effect on rat aorta ex vivo of three silymarin conjugates, silybin A-20-sulfate, silybin B-20-sulfate and 2,3- dehydrosilychristin-19-O-sulfate, and one parent flavonolignan 2,3-

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Yen-Cheng, Shih, and 施彥丞. "The role of AMP-activated kinase in the alpha-lipoic acid-induced vasodilation in rat aorta." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/13267739156004999613.

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碩士<br>國防醫學院<br>藥理學研究所<br>98<br>AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis. Recently, some research reported that it could regulate the vasomotion of vascular smooth muscle. Alpha-lipoic acid, a medicine used to treat diabetic neuropathy, has been found it could affect activity of AMPK in hypothalamus, skeletal muscle, and adipose tissue. However, there is no study to investigate whether AMPK involves the vasomotion induced by alpha-lipoic acid in vascular smooth muscle. Thus, the aim of our study was to investigate the effect and po

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