Academic literature on the topic 'And zero order release'

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Journal articles on the topic "And zero order release"

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Kendall, M. J. "METOPROLOL—CONTROLLED RELEASE, ZERO ORDER KINETICS." Journal of Clinical Pharmacy and Therapeutics 14, no. 3 (1989): 159–79. http://dx.doi.org/10.1111/j.1365-2710.1989.tb00235.x.

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Vyavahare, N. R., M. G. Kulkarni, and R. A. Mashelkar. "Zero order release from swollen hydrogels." Journal of Membrane Science 54, no. 1-2 (1990): 221–28. http://dx.doi.org/10.1016/s0376-7388(00)82081-5.

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UCHIDA, Takahiro, Noboru SEKIYA, Yuka TOIDA, et al. "Zero-Order Release from Cylindrical Xerogel Preparation." CHEMICAL & PHARMACEUTICAL BULLETIN 47, no. 11 (1999): 1655–58. http://dx.doi.org/10.1248/cpb.47.1655.

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Varelas, Charalambos G., David G. Dixon, and Carol A. Steiner. "Zero-order release from biphasic polymer hydrogels." Journal of Controlled Release 34, no. 3 (1995): 185–92. http://dx.doi.org/10.1016/0168-3659(94)00085-9.

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Kuu, Wei-Youh, and Samuel H. Yalkowsky. "Multiple-Hole Approach to Zero-Order Release." Journal of Pharmaceutical Sciences 74, no. 9 (1985): 926–33. http://dx.doi.org/10.1002/jps.2600740904.

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Fina, Fabrizio, Alvaro Goyanes, Martin Rowland, Simon Gaisford, and Abdul W. Basit. "3D Printing of Tunable Zero-Order Release Printlets." Polymers 12, no. 8 (2020): 1769. http://dx.doi.org/10.3390/polym12081769.

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Zero-order release formulations are designed to release a drug at a constant rate over a prolonged time, thus reducing systemic side effects and improving patience adherence to the therapy. Such formulations are traditionally complex to manufacture, requiring multiple steps. In this work, fused deposition modeling (FDM) 3D printing was explored to prepare on-demand printlets (3D printed tablets). The design includes a prolonged release core surrounded by an insoluble shell able to provide zero-order release profiles. The effect of drug loading (10, 25, and 40% w/w paracetamol) on the mechanical and physical properties of the hot melt extruded filaments and 3D printed formulations was evaluated. Two different shell 3D designs (6 mm and 8 mm diameter apertures) together with three different core infills (100, 50, and 25%) were prepared. The formulations showed a range of zero-order release profiles spanning 16 to 48 h. The work has shown that with simple formulation design modifications, it is possible to print extended release formulations with tunable, zero-order release kinetics. Moreover, by using different infill percentages, the dose contained in the printlet can be infinitely adjusted, providing an additive manufacturing route for personalizing medicines to a patient.
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Saba, R. Shaikh* Pradnya Gangurde Shradha Kandalkar Kajal Choursiya Sheetal Gondkar Rishikesh Bachhav. "An Overview on Controlled Porosity Osmotic Tablet." International Journal of Pharmaceutical Sciences 2, no. 5 (2024): 1181–93. https://doi.org/10.5281/zenodo.11245201.

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Due to their incapacity to confine and localize the system at specific parts of the gastrointestinal tract, formulation scientists have faced difficulties in developing oral controlled release systems. A well-characterized dosage form that regulates medication intake into the body within the parameters of the intended release profile has been created using a variety of physical and chemical techniques. The most dependable method for delivering drugs under control is thought to be osmotic pumps. Drug release from ODDS is regulated and not influenced by the dissolution medium's pH or thermodynamics. Drug release from ODDS occurs according to zero order kinetics. Numerous formulation criteria, including solubility, the osmotic pressure of the core components, the size of the delivery orifice, and the type of rate-controlling membrane, affect how quickly a medication releases from an osmotic system. The medicine, osmogens, and excipients are contained in the core of the controlled porosity osmotic pump (CPOP), which is coated with a semipermeable membrane containing water soluble additives. Water soluble additives in CPOP dissolve when they come into contact with water, causing an in situ microporous membrane to develop. This paper provides an overview of osmosis, CPOP, its constituent parts, and its assessment.
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Hamdan Alkhraisat, Mohammad, Claus Moseke, Luis Blanco, Jake E. Barralet, Enrique Lopez-Carbacos, and Uwe Gbureck. "Strontium modified biocements with zero order release kinetics." Biomaterials 29, no. 35 (2008): 4691–97. http://dx.doi.org/10.1016/j.biomaterials.2008.08.026.

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Andjelić, Saša, Jenny Yuan, Dennis D. Jamiolkowski, et al. "Hydrophilic Absorbable Copolyester Exhibiting Zero-Order Drug Release." Pharmaceutical Research 23, no. 4 (2006): 821–34. http://dx.doi.org/10.1007/s11095-006-9664-3.

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NISHI, Tsugio, Shouji TANJI, Yuuichi KOIKE, and Akio EBIHARA. "A compartment model for a sustained release preparation with zero-order release." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 19, no. 4 (1988): 741–47. http://dx.doi.org/10.3999/jscpt.19.741.

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Dissertations / Theses on the topic "And zero order release"

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Sinha, Piyush M. "Nanoengineered implantable devices for controlled drug delivery." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1115138930.

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Zhi, Kaining. "Formulation and Fabrication of a Novel Subcutaneous Implant for the Zero-Order Release of Selected Protein and Small Molecule Drugs." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/482373.

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Pharmaceutical Sciences<br>Ph.D.<br>Diabetes is a leading cause of death and disability in the United States. Diabetes requires a lifetime medical treatment. Some diabetes drugs could be taken orally, while others require daily injection or inhalation to maximize bioavailability and minimize toxicity. Parenteral delivery is a group of delivery routes which bypass human gastrointestinal track. Among all the parenteral methods, we chose subcutaneous implant based on its fast act and high patient compliance. When using subcutaneous implant, drug release needs to be strictly controlled. There are three major groups of controlled release methods. Solvent controlled system is already used as osmotic implant. Matrix controlled system is used in Zoladex® implant to treat cancer. Membrane controlled systems is widely used in coating tablets, but not that popular as an implant. Based on the research reported by previous scientists, we decided to build a hybrid system using both matrix and membrane control to delivery human insulin and other small molecule drugs. Subcutaneous environment is different from human GI track. It has less tolerance for external materials so many polymers cannot be used. From the FDA safe excipient database, we selected albumin as our primary polymer and gelatin as secondary choice. In our preliminary insulin diffusion study, we successfully found that insulin mixed with albumin provided a slower diffusion rate compared with control. In addition, we added zinc chloride, a metal salt that can precipitate albumin. The insulin diffusion rate is further reduced. The preliminary study proved that matrix control using albumin is definitely feasible and we might add zinc chloride as another factor. In order to fabricate an implant with appropriate size, we use lyophilisation technology to produce uniformly mixed matrix. Apart from albumin and human insulin, we added sucrose as protectant and plasticizer. The fine powder after freeze-dry was pressed as a form of tablet. The tablets were sealed in Falcon® cell culture insert. Cell culture insert provide a cylinder shape and 0.3 cm2 surface area for drug release. Insulin release study provided a zero order kinetics from prototypes with zinc chloride or 0.4 micron pore size membrane. Caffeine was used as a model drug to investigate the releasing mechanism. Three pore size membranes (0.4, 3 and 8 micron) were tested with same formulation. While 0.4 micron prototypes provided the slowest release, 3 micron ones surprisingly released caffeine faster than 8 micron implants. We calculated the porosity with pore size and concluded that the percentage of open area on a membrane is the key point to control caffeine release. 0.4 micron membranes were used for future research. We increased the percentage of albumin in our excipient, and achieved a slower caffeine release. However, the zero order release could only last for 3 days. After we replaced sucrose with gelatin, a 5 day zero order release of caffeine was achieved. With all the results, we proposed our “Three Phase” drug release mechanism controlled by both membrane and matrix. Seven other small molecule drugs were tested using our prototype. Cloudy suspension was observed with slightly soluble drugs. We updated our “Three Phase” drug release mechanism with the influence of drug solubility. Data shows that releasing rate with same formulation and membrane follows the solubility in pH 7.4. This result proves that our prototype might be used for different drugs based on their solubility. Finally, with all the information of our prototype, we decided to build a “smart insulin implant” with dose adjustment. We proposed an electrical controlled implant with different porosity membranes. Solenoid was used as the mechanical arm to control membrane porosity. 3-D printing technology was used to produce the first real prototype of our implant. Finally, insulin implant with clinically effective insulin release rate was achieved.<br>Temple University--Theses
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Liu, Quan. "Development of a novel gastro-retentive delivery system using alfuzosin HCl as a model drug." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/80170.

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Pharmaceutics;<br>Ph.D.<br>The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gastro-retentive dosage forms have been the topic of interest in recent years as a practical approach in drug deliveries to the upper GI tract or for release prolongation and absorption. These dosage forms are particularly suitable for drugs that have local effects on the gastric mucosa in the stomach. Other candidates include drugs that are likely to be absorbed in the upper small intestine, or drugs that are unstable in basic environment of distal intestine and colon or those with low solubility at elevated pH conditions (i.e. weak bases). To develop a gastro-retentive delivery system the following steps were taken. First, to investigate the possible incompatibility issues between the model drug and excipients to be used for the delivery system. Stability and physicochemical properties of the active agent and its mixture with excipients were studied using analytical techniques such as Raman spectroscopy and Differential scanning calorimetry (DSC). No incompatibility issues were detected. Second, Kollidon SR as a relatively new release-rate controlling polymer was incorporated in the final formulation. For solid dosage form the ability of the final powder mix to flow well during manufacturing and the intrinsic characteristics that make it compressible are critical. The in-depth compaction study of Kollidon SR was assessed with the help of a compaction simulator. The flowability, swelling and erosion behavior together with release-rate retarding properties of Kollidon SR were also assessed. The final oral delivery system was based on Kollidon SR and Polyethylene Oxide (PEO) 303 as a monolithic matrix system. The noneffervescent monolithic matrix was made by direct compression. In vitro evaluation of the designed system released the active content in a near zero manner. The dosage form was bouyant in pH 2.0 acidic buffer with no floatation lag time which minimizes the possibility of early gastric emptying.
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Guzman, Cardozo Gustavo A. Guzman. "Bimodal Amphiphilic Polymer Conetworks: Structure-Property Characterization, Processing and Applications." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1471428782.

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Dekyndt, Bérengère. "La libération modifiée de principes actifs, développement de deux approches." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S005.

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Les thérapeutiques individualisées et ciblées se développent actuellement, les formes galéniques évoluent donc en parallèle pour contrôler la libération des principes actifs (PA) et les conduire au plus proche des sites d’intérêts. Les formes orales solides représentent les formulations galéniques les plus utilisées, faciles d’emploi, indolores et réduisant le risque d’infection. Lors de leur conception, il est aussi possible de moduler la libération du PA.Deux approches sont étudiées dans ce manuscrit, l’une correspond au ciblage de la libération d’un PA vers son site d’action thérapeutique qui est le colon, la seconde consiste à contrôler la libération du PA pour maintenir une concentration constante, minimiser les effets indésirables et les périodes de présence de concentrations sub-thérapeutiques au niveau du site d’action.Première approche :Les traitements des Maladies Inflammatoires Chroniques de l’Intestin (MICI) peuvent être significativement améliorées par une libération localisée du PA. Une des approches est l’utilisation d’enrobages composés de polysaccharides dégradés par les enzymes sécrétées par la microflore colique. Mais l’absence d’une méthode in vitro reproductible simulant les conditions physiologiques du colon et l’impact potentiel des traitements antibiotiques associées qui pourraient affecter la quantité et la qualité des bactéries présentes et des enzymes sécrétées est un obstacle à sa mise au point. L’objectif de l’étude était d’effectuer un screening de polysaccharides ayant un intérêt dans le développement de nouvelles formulations à libération colique. Après cette sélection, la libération des formulations retenues ont été évaluées par une méthode utilisant des selles de patients atteints de MICI traités ou non par antibiothérapie. Enfin, l’utilisation de mélanges bactériens pour un éventuel remplacement de l’utilisation de selles fraiches a été évaluée.Seconde approche : Les formes orales enrobées présentent un grand potentiel pour la libération contrôlée de PA. Néanmoins, il est difficile d’obtenir une libération à vitesse constante avec ce type de formulation. Ceci est généralement dû au rôle prédominant du transport de masse par diffusion, ce qui entraine, avec le temps, une diminution de la concentration en PA au cœur du système, donc une réduction du gradient de concentration qui est la force motrice de la libération du PA. Ce type de cinétique de libération peut être inapproprié pour un traitement médicamenteux sûr et efficace. Malgré l’importance pratique de ce défi crucial de formulation, étonnamment, peu de stratégies efficaces sont connues. Dans cette étude, une nouvelle approche, basée sur une succession de couches de PA et de polymères (initialement dépourvu de PA) présentant une distribution initiale de PA non homogène, associé à un effet de temps de latence et à une diffusion partielle initiale à travers le noyau de la minigranule. Des variations de type, de quantité, d’épaisseur et de séquence des couches de PA et de polymères ont été testées. Un système assez simple composé de quatre couches (deux couches de PA et deux couches de polymère) permettait d’aboutir à une libération relativement constante durant 8h<br>Individualized and targeted therapies are currently developed, therefore the dosage forms move in parallel to control the drug release and drive it nearest to interest sites. Solid oral dosage forms are the pharmaceutical formulations the most common, easy to use, painless and reducing the infectious risk. In these formulation designs, it is also possible to adjust the drug release.Two approaches are discussed in this manuscript, the first one targets the drug release to the therapeutic site of action which is the colon, and the second one consists on controlling the drug release to maintain a constant concentration, minimize side effects and periods of presence of sub-therapeutic concentrations at the site of action.The first approach:The treatment of colonic disease like Inflammatory Bowel Diseases (IBD), can be significantly improved via local drug delivery. One approach is to use polysaccharide coatings, which are degraded by enzymes secreted by the colonic microflora. However, the lack of a reliable in vitro test simulating conditions in a living colon and the potential impact of associated antibiotic treatments that could affect the quality and quantity of bacteria and enzymes secreted is an obstacle to its development. The aim of the study was to perform a screening of polysaccharides suitable for the development of new colonic release formulations. After this selection, the drug release of selected formulations were evaluated by a method using the stools of IBD patients treated or not with antibiotics. Finally, the use of bacterial mixtures substituting fresh fecal samples has been evaluated.The second approach: Coated pellets offer a great potential for controlling drug delivery systems. However, constant drug release rates are difficult to achieve with this type of dosage forms if the drug is freely water-soluble. This is because diffusional mass transport generally plays a major role and with time the drug concentration within the system decreases, resulting in decreased concentration gradients, which are the driving forces for drug release. This type of release kinetics might be inappropriate for an efficient and safe drug treatment. Despite the great practical importance of this potentially crucial formulation challenge, surprisingly little is yet known about efficient formulations. In this study, a novel approach is presented based on sequential layers of drug and polymer (initially free of drug) to provide a non-homogeneous initial drug distribution, combined with lag-time effects and partial initial drug diffusion towards the pellet’s core. By changing the type, number, thickness and sequence of the drug and polymer layers, a rather simple 4 layers system (2 drug and 2 polymer layers) allowed an about constant drug release during 8 h
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Vainio, Tanja 1974. "Intelligent order scheduling and release in a build to order environment." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/34780.

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Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering; in conjunction with the Leaders for Manufacturing Program at MIT, 2004.<br>Includes bibliographical references (p. 75-76).<br>Dell's computer manufacturing process involves a complex system of material flow and assembly. This includes intelligent replenishment of sub-components from local warehouses according to the manufacturing schedule, just-in-time manufacturing of custom configured computer systems including hard-drive image and custom software download, packaging the unit for delivery, order accumulation, and finally, distribution and shipping to the customer. This thesis examines Dell's current order fulfillment process and suggests methods that can help Dell meet or exceed customers' delivery time air shipments to certain destinations could be converted to less expensive ground shipments. However, this is only possible when the entire fulfillment process is integrated in such a way that eligible ground shipments meet their appropriate shipping windows. This analysis shows that optimizing these windows not only requires an examination of the average cycle time in each phase but also of the impact that cycle time variations have on the expectations at minimum logistics cost in the just-in-time environment. By manufacturing and shipping products based on certain times of the day, success of this air-to-ground conversion strategy. Through the use of simulation models I found that the key factors in reducing logistics cost require setting appropriate scheduling rules for each order size and reducing the cycle time variation.<br>by Tanja Vainio.<br>S.M.<br>M.B.A.
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Azoza, M. A. "Disaggregation and order release in manufacturing systems." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378757.

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Aktug, Onur. "An Agent-based Order Review And Release System In Make-to-order Production." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/2/12605611/index.pdf.

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Workload control (WLC) systems constitute a framework mainly for the inputoutput control systems which regulate both jobs&rsquo<br>queues into the workshop and the flow of finished goods out of the workshop. This study is concerned with the job entry and release level of WLC which maintains a pool of unreleased jobs for the controlled release of jobs. While most of the studies in WLC concepts deal with the centralized workload control, our study decentralizes the job entry and release control and makes workstations more powerful in schedule decision making. Job&rsquo<br>s information is sent to the workstations by mediator which is the supervisor of the workstation. Both mediator and work stations are represented by agents in a distributed system. Jobs&rsquo<br>routing information is assumed to be known in advance. The developed system is verified and validated by means of test runs. Results are analyzed as well.
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Alsuhibany, Suliman Abdullah. "Quantitative analysis of the release order of defensive mechanisms." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2549.

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Dependency on information technology (IT) and computer and information security (CIS) has become a critical concern for many organizations. This concern has essentially centred on protecting secrecy, confidentiality, integrity and availability of information. To overcome this concern, defensive mechanisms, which encompass a variety of services and protections, have been proposed to protect system resources from misuse. Most of these defensive mechanisms, such as CAPTCHAs and spam filters, rely in the first instance on a single algorithm as a defensive mechanism. Attackers would eventually break each mechanism. So, each algorithm would ultimately become useless and the system no longer protected. Although this broken algorithm will be replaced by a new algorithm, no one shed light on a set of algorithms as a defensive mechanism. This thesis looks at a set of algorithms as a holistic defensive mechanism. Our hypothesis is that the order in which a set of defensive algorithms is released has a significant impact on the time taken by attackers to break the combined set of algorithms. The rationale behind this hypothesis is that attackers learn from their attempts, and that the release schedule of defensive mechanisms can be adjusted so as to impair the learning process. To demonstrate the correctness of our hypothesis, an experimental study involving forty participants was conducted to evaluate the effect of algorithms’ order on the time taken to break them. In addition, this experiment explores how the learning process of attackers could be observed. The results showed that the order in which algorithms are released has a statistically significant impact on the time attackers take to break all algorithms. Based on these results, a model has been constructed using Stochastic Petri Nets, which facilitate theoretical analysis of the release order of a set of algorithms approach. Moreover, a tailored optimization algorithm is proposed using a Markov Decision Process model in order to obtain efficiently the optimal release strategy for any given model by maximizing the time taken to break a set of algorithms. As our hypothesis is based on the learning acquisition ability of attackers while interacting with the system, the Attacker Learning Curve (ALC) concept is developed. Based on empirical results of the ALC, an attack strategy detection approach is introduced and evaluated, which has achieved a detection success rate higher than 70%. The empirical findings in this detection approach provide a new understanding of not only how to detect the attack strategy used, but also how to track the attack strategy through the probabilities of classifying results that may provide an advantage for optimising the release order of defensive mechanisms.
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Ratsibi, Humbelani Edzani. "Laser drilling of metals and glass using zero-order bessel beams." University of the Western Cape, 2013. http://hdl.handle.net/11394/5428.

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>Magister Scientiae - MSc<br>This dissertation consists of two main sections. The first section focuses on generating zero order Bessel beams using axicons. An axicon with an opening angle y = 5⁰ was illuminated with a Gaussian beam of width ω₀ = 1.67 mm from a cw fiber laser with central wavelength λ = 1064 nm to generate zero order Bessel beams with a central spot radius r₀ = 8.3 ± 0.3 μm and propagation distance ½zmax = 20.1 ± 0.5 mm. The central spot size of a Bessel beam changes slightly along the propagation distance. The central spot radius r₀ can be varied by changing the opening angle of the axicon, y, and the wavelength of the beam. The second section focuses on applications of the generated Bessel beams in laser microdrilling. A Ti:Sapphire pulsed femtosecond laser (λ = 775 nm, ω₀ = 2.5 mm, repetition rate kHz, pulse energy mJ, and pulse duration fs) was used to generate the Bessel beams for drilling stainless steel thin sheets of thickness 50 μm and 100 μm and microscopic glass slides 1 mm thick. The central spot radius was r₀ = 15.9 ± 0.3 μm and ½zmax = 65.0 ± 0.5 mm. The effect of the Bessel beam shape on the quality of the holes was analysed and the results were discussed. It was observed that Bessel beams drill holes of better quality on transparent microscopic glass slides than on stainless steel sheet. The holes drilled on stainless steel sheets deviated from being circular on both the top and bottom surface for both thicknesses. However the holes maintained the same shape on both sides of each sample, indicating that the walls are close to being parallel. The holes drilled on the glass slides were circular and their diameters could be measured. The measured diameter (15.4±0.3 μm) of the hole is smaller than the diameter of the central spot (28.2 ± 0.1 μm) of the Bessel beam. Increasing the pulse energy increased the diameter of the drilled hole to a value close to the measured diameter of the central spot.
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Books on the topic "And zero order release"

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Osipov, Andrei, Vladimir Rokhlin, and Hong Xiao. Prolate Spheroidal Wave Functions of Order Zero. Springer US, 2013. http://dx.doi.org/10.1007/978-1-4614-8259-8.

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International Seminar on Advanced Nuclear Energy Systems Toward Zero Release of Radioactive Wastes (2000 Susono, Japan). Advanced nuclear energy systems toward zero release of radioactive wastes. Edited by Saito Masaki ed and Sawada Tetsuo ed. Pergamon, 2002.

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Swartz, S. Constraints on zero anaphora and word order in Warlpiri narrative text. Australian Aborigines and Islanders Branch, Summer Institute of Linguistics, 1991.

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Québec (Province). Direction de la probation., ed. The Community work order: A substitute for imprisonment. Ministère du solliciteur général, Direction de la probation, 1986.

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Legislation, Great Britain Parliament House of Commons Fourth Standing Committee on Delgated. Draft release of short-term prisoners on licence (amendment of requisite period) order 2002. Thursday 21 November 2002. Stationery Office, 2002.

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Great Britain. Parliament. House of Commons. Fourth Standing Committee on Delgated Legislation. Draft release of short-term prisoners on licence(amendment of requisite period)order 2003: Thursday 22 May 2003. The Stationery Office, 2003.

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Great Britain. Parliament. House of Commons. First Standing Committee on Delegated Legislation. Draft release of short-term prisoners on licence (Repeal of Age Restriction) Order 2003, Monday 23 June 2003. Stationery Office, 2003.

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Saribun, Daud S. Hubungan kandungan mineral-mineral ordo kisaran pendek (short range order minerals) dengan muatan titik nol (zero point of charge) pada andisol: Laporan penelitian. Fakultas Pertanian, Universitas Padjadjaran, 1997.

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Miller, George P. Chemical release and radiation effects (CRRES) data directory: Final report on NAS8-38609, delivery order #69 for the reporting period 02/24/93 - 04/24/93. National Aeronautics and Space Administration, 1993.

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United States. National Aeronautics and Space Administration., ed. Chemical release and radiation effects (CRRES) data directory: Final report on NAS8-38609, delivery order #69 for the reporting period 02/24/93 - 04/24/93. National Aeronautics and Space Administration, 1993.

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Book chapters on the topic "And zero order release"

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Talevi, Alan, and María Esperanza Ruiz. "Zero-Order Drug Release." In The ADME Encyclopedia. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84860-6_33.

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Talevi, Alan, and María E. Ruiz. "Zero-Order Drug Release." In The ADME Encyclopedia. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51519-5_33-1.

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Zhang, Xue, Xiao Liu, Ze-Hui Wei, and Yan-Ping Huang. "Special Control by Molecularly Imprinted Materials-Zero-Order Sustained Release, Enantioselective MIPs, and Self-Regulated Drug Delivery Microdevices." In Molecularly Imprinted Polymers as Advanced Drug Delivery Systems. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0227-6_3.

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Ark, Neelam. "Zero-Order Relationships." In Encyclopedia of Quality of Life and Well-Being Research. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-0753-5_3306.

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Ark, Neelam. "Zero-Order Relationships." In Encyclopedia of Quality of Life and Well-Being Research. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-17299-1_3306.

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Sutin, N. "Of Zero Order." In Inorganic Reactions and Methods. John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145302.ch14.

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Zohar, Danah. "A Quantum Global Order." In Zero Distance. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-7849-3_23.

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Mönch, Lars, John W. Fowler, and Scott J. Mason. "Order Release Approaches." In Operations Research/Computer Science Interfaces Series. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-4472-5_6.

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Dalton, Jeff. "Big Room Planning / Release Zero." In Great Big Agile. Apress, 2018. http://dx.doi.org/10.1007/978-1-4842-4206-3_17.

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Duka, Theodora, Kim Wolff, W. Wolfgang Fleischhacker, et al. "Zero-Order Elimination Kinetics." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1523.

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Conference papers on the topic "And zero order release"

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Bar, Noga, and Raja Giryes. "ZOQO: Zero-Order Quantized Optimization." In ICASSP 2025 - 2025 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). IEEE, 2025. https://doi.org/10.1109/icassp49660.2025.10887815.

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Deng, Yichuan, Zhihang Li, Sridhar Mahadevan, and Zhao Song. "Zero-th Order Algorithm for Softmax Attention Optimization." In 2024 IEEE International Conference on Big Data (BigData). IEEE, 2024. https://doi.org/10.1109/bigdata62323.2024.10825630.

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Li, Jian, Qiang Shao, Yuanquan Liu, Yiting Wang, and Yan Liu. "A Novel Smoothing Framework for Interval-zero-order Takagi-Sugeno Fuzzy Neural Networks: Combining Interval Analysis with Zero-order TS Systems." In 2024 International Conference on New Trends in Computational Intelligence (NTCI). IEEE, 2024. https://doi.org/10.1109/ntci64025.2024.10776123.

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An, Qi, Jianxiao Wang, Shengyu Wu, Weikai Ren, Ruanming Huang, and Gengyin Li. "Zero-Order Optimization in Security Constrained Power System Scheduling." In 2024 International Conference on Electrical, Computer and Energy Technologies (ICECET). IEEE, 2024. http://dx.doi.org/10.1109/icecet61485.2024.10698329.

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Yang, Bei, and Gang Liu. "Miniature Broadband Zero-Order Resonance Antenna for WiMAX Applications." In 2024 4th International Conference on Electronic Information Engineering and Computer Communication (EIECC). IEEE, 2024. https://doi.org/10.1109/eiecc64539.2024.10929220.

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Cheng, X., T. C. Ionescu, O. V. Iftime, and I. Necoara. "Moment matching for second-order systems with pole-zero placement." In 2024 IEEE 63rd Conference on Decision and Control (CDC). IEEE, 2024. https://doi.org/10.1109/cdc56724.2024.10886736.

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Wang, Qian, and Zhipeng Li. "True zero-order waveplates enabled by low-dimensional ferrocene crystals." In Smart Materials for Opto-Electronic Applications 2025, edited by Ivo Rendina, Lucia Petti, Domenico Sagnelli, and Giuseppe Nenna. SPIE, 2025. https://doi.org/10.1117/12.3056264.

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Fontenault, Jeremy, Tara Franey, and Matt Horn. "Assessing Potential Impacts to Waterways From Small Volume Releases Originating From Facilities or Equipment." In 2020 13th International Pipeline Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/ipc2020-9377.

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Abstract The pipeline industry strives for continuous improvement and reaching zero incidents. The risks associated with below grade pipelines are typically assessed in detail as part of operators’ pipeline integrity management program. However, the level of risk associated with above grade facilities and equipment is often not investigated to the same level. As part of an effort, with an anonymous pipeline operator, to refine the calculated risks associated with these facilities and valve sites, a focus was made on enhancing the consequence calculations with more accurate site-specific information. An approach was developed to assess whether smaller volume releases from these locations may impact nearby waterways following a release. The operator identified 150 sites throughout North America where releases had the potential to contaminate a waterbody. In order to confirm/disprove this potential impact to water, hypothetical releases of multiple hydrocarbon products were simulated using oil spill modeling tools to assess the potential overland and downstream transport and fates of the released products. Hypothetical release scenarios were simulated until all of the modeled oil had been released and had either adhered to the land surface, filled a depression in the land surface, and/or evaporated to the atmosphere; or when oil was predicted to enter a perennial waterbody (stream or lake). The goal was to assess the potential for each release to reach a waterbody. A single release was simulated for each site based on a historical maximum volume for a release associated with the specific equipment type (e.g. valves) that could be released over a 24-hour period. Releases were simulated using conditions selected to produce reasonable, conservative results to maximize the potential for the largest volume of oil to enter a waterbody. These conditions were based on the spring season, where rivers and streams would be under some of the highest flow conditions, intermittent streams and waterbodies would contain water feeding larger water bodies, cool air temperatures would reduce evaporative losses, and no snow cover maximize overland transport. This screening level analysis allowed for identification of each location’s potential to reach a nearby waterbody under the conservative set of conditions and assumptions. By eliminating sites where oil would not reach a waterbody, the operator was able to focus efforts on the highest consequence areas in order to complete more detailed field-level analysis. In regard to spill modeling, more detailed analyses could be conducted in the future to predict the range of possible outcomes from other types of releases and using more site-specific and season-specific data. As an example, slower releases/leak rates, enhanced evaporative losses, a range of environmental conditions, and/or losses to infiltration could be assessed to bound the range of potential impacts.
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Rangel-Vázquez, Norma-Aurea, Nancy Delgadillo-Armendariz, and Jonathan Kalla. "Study of the Adsorption of Glibenclamide/Metformine in Hydrogels Using PM6 Model." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6935.

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In the present work the physical-chemical and energetic properties of the molecules of hydrogels about chitosan crosslinking with genipin were studied in the adsorption process of Metformine and Glibenclamide. The analysis was done by means of PM6 model in order to obtain the necessary data base to establish their potential use as transdermal controlled release systems. Currently, the drugs (metformine and glibenclamide) are administered orally, however, there are already several oral medications that have been presented as transdermal administration systems (SAT), with great advantages, such as patient comfort and zero order release. Drugs before mentioned, are especially important in chronic diseases such as type 2 diabetes.
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Medina, Lior, Rivka Gilat, and Slava Krylov. "Bow Actuator: Low Voltage Switching in Electrostatically Actuated Bistable Beams." In ASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/detc2018-85534.

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Curved bistable beams subjected to transverse loading may exhibit latching, namely remain in their buckled state under zero force. Under such circumstances, an opposite force is required for snapping-back (release) of the beam to its initial configuration. For an electrostatically actuated beam, two electrodes located at either side of the beam may therefore be required for bidirectional actuation. In this study, a new snapping and release procedures, are considered. The approach involves the preloading of the beam using an electrostatic force in the direction opposite to the beam desired movement, followed by a sudden release of the voltage. We show, by means of a reduced order (RO) model, resulting from the Galerkin decomposition, that such an actuation paradigm can not only be used to release a beam from its latched position, but can also create a snap-through response at a significantly low voltage.
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Reports on the topic "And zero order release"

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Messerly, M. Zero-Order Phased Fiber Arrays. Office of Scientific and Technical Information (OSTI), 2010. http://dx.doi.org/10.2172/974858.

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Dixit, S., D. Kalantar, and R. Lyons. Impact of zero order unconverted light on beam pointing. Office of Scientific and Technical Information (OSTI), 1999. http://dx.doi.org/10.2172/13900.

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Gue, Kevin R., and Erdem Ceven. Wave Release Strategies to Improve Service in Order Fulfillment Systems. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada584663.

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Raubenheimer, T. O. NLC ZDR: Zero Order Design Report for the NEXT Linear Collider (Volume 1). Office of Scientific and Technical Information (OSTI), 2018. http://dx.doi.org/10.2172/1454144.

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Raubenheimer, T. O. NLC ZDR: Zero Order Design Report for the NEXT Linear Collider (Volume 2). Office of Scientific and Technical Information (OSTI), 2018. http://dx.doi.org/10.2172/1454145.

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Ammer, J. R. Identification of data gaps found during the development of a zero-order model for a fluidized-bed retort/combustion process. Office of Scientific and Technical Information (OSTI), 1986. http://dx.doi.org/10.2172/6107518.

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Venedicto, Melissa, and Cheng-Yu Lai. Facilitated Release of Doxorubicin from Biodegradable Mesoporous Silica Nanoparticles. Florida International University, 2021. http://dx.doi.org/10.25148/mmeurs.009774.

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Cervical cancer is one of the most common causes of cancer death for women in the United States. The current treatment with chemotherapy drugs has significant side effects and may cause harm to healthy cells rather than cancer cells. In order to combat the potential side effects, nanoparticles composed of mesoporous silica were created to house the chemotherapy drug doxorubicin (DOX). The silica network contains the drug, and a pH study was conducted to determine the conditions for the nanoparticle to disperse the drug. The introduction of disulfide bonds within the nanoparticle created a framework to efficiently release 97% of DOX in acidic environments and 40% release in neutral environments. The denotation of acidic versus neutral environments was important as cancer cells are typically acidic. The chemistry was proved with the incubation of the loaded nanoparticle into HeLa cells for a cytotoxicity report and confocal imaging. The use of the framework for the anticancer drug was shown to be effective for the killing of cancerous cells.
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Tosi, R., R. Codina, J. Principe, R. Rossi, and C. Soriano. D3.3 Report of ensemble based parallelism for turbulent flows and release of solvers. Scipedia, 2022. http://dx.doi.org/10.23967/exaqute.2022.3.06.

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In this work we focus on reducing the wall clock time required to compute statistical estimators of highly chaotic incompressible flows on high performance computing systems. Our approach consists of replacing a single long-term simulation by an ensemble of multiple independent realizations, which are run in parallel with different initial conditions. A failure probability convergence criteria must be satisfied by the statistical estimator of interest to assess convergence. Its error analysis leads to the identification of two error contributions: the initialization bias and the statistical error. We propose an approach to systematically detect the burn-in time in order to minimize the initialization bias, accompanied by strategies to reduce simulation cost. The framework is validated on two very high Reynolds number obstacle problems of wind engineering interest in a high performance computing environment.
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Brozovsky, Johannes, Odne Oksavik, and Petra Rüther. Temperature measurements in the air gap of highly insulated wood-frame walls in a Zero Emission Building. Department of the Built Environment, 2023. http://dx.doi.org/10.54337/aau541595903_2.

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Especially for wooden wall constructions, ventilated rain-screen walls have been used for many decades to prohibit moisture-induced damage. The air gap behind the façade cladding provides drainage, enhances ventilation, and thus facilitates drying of wetted façade components. The conditions in the air gap behind different cladding materials, however, are still an object of research. In the presented study, the interim findings after more than two years of ongoing measurements in the air gap behind different cladding materials of a zero-emission office building in the high-latitude city of Trondheim, Norway are presented. The results provide valuable insight into the temperature conditions in the air gap of ventilated claddings in order to determine the in-use conditions of building materials and develop improved testing schemes. The results indicate that the air and surface temperature in the air cavity of the walls is strongly influenced by the solar radiation incidence on the facades. Both the highest and lowest values were observed on the roof with 81 °C and -21.9 °C, respectively, at the back side of the building integrated photovoltaic modules, resulting in a total temperature range of almost 103 °C.
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Brozovsky, Johannes, Odne Oksavik, and Petra Rüther. Temperature measurements in the air gap of highly insulated wood-frame walls in a Zero Emission Building. Department of the Built Environment, 2023. http://dx.doi.org/10.54337/aau541595903.

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Especially for wooden wall constructions, ventilated rain-screen walls have been used for many decades to prohibit moisture-induced damage. The air gap behind the façade cladding provides drainage, enhances ventilation, and thus facilitates drying of wetted façade components. The conditions in the air gap behind different cladding materials, however, are still an object of research. In the presented study, the interim findings after more than two years of ongoing measurements in the air gap behind different cladding materials of a zero-emission office building in the high-latitude city of Trondheim, Norway are presented. The results provide valuable insight into the temperature conditions in the air gap of ventilated claddings in order to determine the in-use conditions of building materials and develop improved testing schemes. The results indicate that the air and surface temperature in the air cavity of the walls is strongly influenced by the solar radiation incidence on the facades. Both the highest and lowest values were observed on the roof with 81 °C and -21.9 °C, respectively, at the back side of the building integrated photovoltaic modules, resulting in a total temperature range of almost 103 °C.
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