Journal articles: 'And zero order release'

1

Kendall, M. J. "METOPROLOL—CONTROLLED RELEASE, ZERO ORDER KINETICS." Journal of Clinical Pharmacy and Therapeutics 14, no. 3 (1989): 159–79. http://dx.doi.org/10.1111/j.1365-2710.1989.tb00235.x.

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Vyavahare, N. R., M. G. Kulkarni, and R. A. Mashelkar. "Zero order release from swollen hydrogels." Journal of Membrane Science 54, no. 1-2 (1990): 221–28. http://dx.doi.org/10.1016/s0376-7388(00)82081-5.

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UCHIDA, Takahiro, Noboru SEKIYA, Yuka TOIDA, et al. "Zero-Order Release from Cylindrical Xerogel Preparation." CHEMICAL & PHARMACEUTICAL BULLETIN 47, no. 11 (1999): 1655–58. http://dx.doi.org/10.1248/cpb.47.1655.

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Varelas, Charalambos G., David G. Dixon, and Carol A. Steiner. "Zero-order release from biphasic polymer hydrogels." Journal of Controlled Release 34, no. 3 (1995): 185–92. http://dx.doi.org/10.1016/0168-3659(94)00085-9.

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Kuu, Wei-Youh, and Samuel H. Yalkowsky. "Multiple-Hole Approach to Zero-Order Release." Journal of Pharmaceutical Sciences 74, no. 9 (1985): 926–33. http://dx.doi.org/10.1002/jps.2600740904.

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Fina, Fabrizio, Alvaro Goyanes, Martin Rowland, Simon Gaisford, and Abdul W. Basit. "3D Printing of Tunable Zero-Order Release Printlets." Polymers 12, no. 8 (2020): 1769. http://dx.doi.org/10.3390/polym12081769.

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Zero-order release formulations are designed to release a drug at a constant rate over a prolonged time, thus reducing systemic side effects and improving patience adherence to the therapy. Such formulations are traditionally complex to manufacture, requiring multiple steps. In this work, fused deposition modeling (FDM) 3D printing was explored to prepare on-demand printlets (3D printed tablets). The design includes a prolonged release core surrounded by an insoluble shell able to provide zero-order release profiles. The effect of drug loading (10, 25, and 40% w/w paracetamol) on the mechanical and physical properties of the hot melt extruded filaments and 3D printed formulations was evaluated. Two different shell 3D designs (6 mm and 8 mm diameter apertures) together with three different core infills (100, 50, and 25%) were prepared. The formulations showed a range of zero-order release profiles spanning 16 to 48 h. The work has shown that with simple formulation design modifications, it is possible to print extended release formulations with tunable, zero-order release kinetics. Moreover, by using different infill percentages, the dose contained in the printlet can be infinitely adjusted, providing an additive manufacturing route for personalizing medicines to a patient.

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Saba, R. Shaikh* Pradnya Gangurde Shradha Kandalkar Kajal Choursiya Sheetal Gondkar Rishikesh Bachhav. "An Overview on Controlled Porosity Osmotic Tablet." International Journal of Pharmaceutical Sciences 2, no. 5 (2024): 1181–93. https://doi.org/10.5281/zenodo.11245201.

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Due to their incapacity to confine and localize the system at specific parts of the gastrointestinal tract, formulation scientists have faced difficulties in developing oral controlled release systems. A well-characterized dosage form that regulates medication intake into the body within the parameters of the intended release profile has been created using a variety of physical and chemical techniques. The most dependable method for delivering drugs under control is thought to be osmotic pumps. Drug release from ODDS is regulated and not influenced by the dissolution medium's pH or thermodynamics. Drug release from ODDS occurs according to zero order kinetics. Numerous formulation criteria, including solubility, the osmotic pressure of the core components, the size of the delivery orifice, and the type of rate-controlling membrane, affect how quickly a medication releases from an osmotic system. The medicine, osmogens, and excipients are contained in the core of the controlled porosity osmotic pump (CPOP), which is coated with a semipermeable membrane containing water soluble additives. Water soluble additives in CPOP dissolve when they come into contact with water, causing an in situ microporous membrane to develop. This paper provides an overview of osmosis, CPOP, its constituent parts, and its assessment.

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Hamdan Alkhraisat, Mohammad, Claus Moseke, Luis Blanco, Jake E. Barralet, Enrique Lopez-Carbacos, and Uwe Gbureck. "Strontium modified biocements with zero order release kinetics." Biomaterials 29, no. 35 (2008): 4691–97. http://dx.doi.org/10.1016/j.biomaterials.2008.08.026.

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Andjelić, Saša, Jenny Yuan, Dennis D. Jamiolkowski, et al. "Hydrophilic Absorbable Copolyester Exhibiting Zero-Order Drug Release." Pharmaceutical Research 23, no. 4 (2006): 821–34. http://dx.doi.org/10.1007/s11095-006-9664-3.

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NISHI, Tsugio, Shouji TANJI, Yuuichi KOIKE, and Akio EBIHARA. "A compartment model for a sustained release preparation with zero-order release." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 19, no. 4 (1988): 741–47. http://dx.doi.org/10.3999/jscpt.19.741.

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Ranga Rao, K. V., K. Padmalatha Devi, and P. Buri. "Cellulose Matrices for Zero-Order Release of Soluble Drugs." Drug Development and Industrial Pharmacy 14, no. 15-17 (1988): 2299–320. http://dx.doi.org/10.3109/03639048809152017.

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12

Wang, Zuwei, Mian Fu, Yuanpeng Wang, Qingbin Meng, Ying Guan, and Yongjun Zhang. "Injectable Carrier for Zero-Order Release of Salmon Calcitonin." ACS Biomaterials Science & Engineering 6, no. 1 (2019): 485–93. http://dx.doi.org/10.1021/acsbiomaterials.9b01680.

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Posey-Dowty, Jessica D., Thelma L. Watterson, A. Kent Wilson, Kevin J. Edgar, Michael C. Shelton, and Larry R. Lingerfelt. "Zero-order release formulations using a novel cellulose ester." Cellulose 14, no. 1 (2006): 73–83. http://dx.doi.org/10.1007/s10570-006-9079-7.

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Gargiulo, Nicola, Ilaria De Santo, Filippo Causa, Domenico Caputo, and Paolo Antonio Netti. "Confined mesoporous silica membranes for albumin zero-order release." Microporous and Mesoporous Materials 167 (February 2013): 71–75. http://dx.doi.org/10.1016/j.micromeso.2012.04.003.

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15

Vyavahare, N. R., M. G. Kulkarni, and R. A. Mashelkar. "Zero order release from glassy hydrogels. II. Matrix effects." Journal of Membrane Science 54, no. 1-2 (1990): 205–20. http://dx.doi.org/10.1016/s0376-7388(00)82080-3.

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16

Roorda, W. E., M. A. de Vries, L. G. J. de Leede, A. G. de Boer, D. D. Breimer, and H. E. Junginger. "Zero-order release of oxprenolol-HCl, a new approach." Journal of Controlled Release 7, no. 1 (1988): 45–52. http://dx.doi.org/10.1016/0168-3659(88)90079-x.

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17

Lee, Ping I., and Susan K. Lum. "Swelling-induced zero-order release from rubbery polydimethylsiloxane beads." Journal of Controlled Release 18, no. 1 (1992): 19–24. http://dx.doi.org/10.1016/0168-3659(92)90207-8.

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18

Fu, Mian, Xiaomei Zhuang, Tianhong Zhang, Ying Guan, Qingbin Meng, and Yongjun Zhang. "Hydrogen‐Bonded Films for Zero‐Order Release of Leuprolide." Macromolecular Bioscience 20, no. 9 (2020): 2000050. http://dx.doi.org/10.1002/mabi.202000050.

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19

Pudjiastuti, Pratiwi, Siti Wafiroh, Esti Hendradi, et al. "Disintegration, In vitro Dissolution, and Drug Release Kinetics Profiles of k-Carrageenan-based Nutraceutical Hard-shell Capsules Containing Salicylamide." Open Chemistry 18, no. 1 (2020): 226–31. http://dx.doi.org/10.1515/chem-2020-0028.

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AbstractThe release of drugs from solid drug delivery materials has been studied intently in recent years. Quantitative analyses achieved from in vitro dissolution becomes easier if a zero-order mathematical model is used. Non-gelatin nutraceutical hard-shell capsules of zero size (approximately 0.7-0.8 cm) were produced from carrageenan-based natural polymers, namely carrageenan-alginate (CA) and carrageenan-starch (CS). Disintegration, dissolution and zero-order drug release kinetics of hard-shell capsules containing 100 mg of salicylamide were studied. The disintegration time of CA and CS were observed to be less than 30 min for both CA and CS. In vitro dissolution profile showed that the percentage dissolution of CA capsules was better at pH 4.5, while that of CS was poor at pH 1.2, 4.5 and 6.8. Determination of drug release kinetics profiles of carrageenan-based hardshell capsules utilized the Noyes-Whitney and Peppas-Sahlin modification rules for zero-order. The drug release from carrageenan-based capsules followed zero-order kinetics, especially at pH 6.8, and was compared to the Higuchi model. Salicylamide in CA hard-shell capsules at a pH 6.8 had a release rate constant (kH) of 2.91 %(ppm/ ppm) min-1/2, while the release rate constant of CS was 0.36 %(ppm/ppm) min-1.

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20

Latif, Randa. "Zero-order release profile of metoclopramide hydrochloride sublingual tablet formulation." Pharmaceutical Development and Technology 18, no. 6 (2012): 1372–78. http://dx.doi.org/10.3109/10837450.2012.717950.

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21

Chen, Gan-Lin, and Wei-Hua Hao. "Factors Affecting Zero-Order Release Kinetics of Porous Gelatin Capsules." Drug Development and Industrial Pharmacy 24, no. 6 (1998): 557–62. http://dx.doi.org/10.3109/03639049809085658.

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22

Birajdar, Mallinath S., and Jonghwi Lee. "Sonication-triggered zero-order release by uncorking core–shell nanofibers." Chemical Engineering Journal 288 (March 2016): 1–8. http://dx.doi.org/10.1016/j.cej.2015.11.095.

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23

Baveja, S. K., K. V. Ranga Rao та K. Padmalatha Devi. "Zero-order release hydrophilic matrix tablets of β-adrenergic blockers". International Journal of Pharmaceutics 39, № 1-2 (1987): 39–45. http://dx.doi.org/10.1016/0378-5173(87)90196-7.

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24

Shaik Sajid Ali, Madhu Gudipati, and Ramarao Nadendla. "Development and characterization of miconazole nitrate transfersomal gel." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 4 (2020): 109–16. http://dx.doi.org/10.33974/ijrpst.v1i4.200.

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Miconazole nitrate (MIC) is an antifungal drug used for the treatment of superficial fungal infections. However, it has low skin permeability. Hence, the basic idea behind the development of such a system, transfersomes is to maintain a sustain release of drug from the dosage form and for target delivery. Miconazole nitrate was formulated as transfersomes, half-life can be increased and the desired effect can be obtained. MIC transfersomes were prepared using a thin lipid film hydration technique. The prepared transfersomes were evaluated with respect to entrapment efficiency (EE%), particle size, and quantity of in vitro drug released to obtain an optimized formulation. The optimized formulation of MIC transfersomes was incorporated into a Carbapol 934 gel base which was for drug content, pH, spreadability, viscosity, in vitro permeation, and in vitro activity. The prepared MIC transfersomes had a high EE% ranging from 65.45% to 80.11%, with small particle sizes ranging from 368 nm to 931 nm. The in vitro release study suggested that there was an inverse relationship between EE% and in vitro release. In 24 hrs the drug release was observed ranging from 79.08% to 88.72%. The kinetic analysis of all release profiles was found to follow Higuchi’s diffusion model. All independent variables had a significant effect on the dependent variables (p-values < 0.05). Therefore, Miconazole nitrate in the form of transfersomes has the ability to penetrate the skin, overcoming the stratum corneum barrier. When the data subjected to zero order and first order kinetics model, a linear relationship was observed with high R2 values for zero order model as compared to first order model and suggested that the formulations followed zero order sustained release.

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25

Shaik, Ameer Pasha, and Sowmy Adapa. "Formulation and Evaluation of Phenylephrine Nasal Gels." International Journal of Clinical Pharmacokinetics and Medical Sciences 4, no. 1 (2024): 1–10. http://dx.doi.org/10.26452/ijcpms.v4i1.573.

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The primary objective of this study is to develop and evaluate phenylephrine nasal gels, aiming for stable blood levels with lower drug doses through consistent administration, avoiding first-pass hepatic metabolism. Compatibility among the drug, polymers, and lipids was confirmed using FTIR and DSC spectra. Phenylephrine nasal gels were formulated, and their clarity assessed. The gels (ONGF1-ONGF8) had pH values of 6.1-7.2, spreadability of 18.33-21.62 g/cm/sec, and viscosity of 934.2-966.2 centipoises. Drug concentration in these formulations varied from 85.52% to 98.88%, indicating acceptable medication content. Gel strength ranged from 64% to 95%. In-vitro drug release of phenylephrine showed 77% to 95% diffusion for ONGF1. The release kinetics followed first order, zero order, Higuchi model, and Korsemeyer-Peppas equations. Kinetic values for all formulations were tabulated. ONGF1 exhibited the most efficient release, with 95% of the drug released within 7 hours, demonstrating a diffusion mechanism followed by non-Fickian transport, adhering to both zero order and Korsemeyer-Peppas models.Top of Form

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26

Jaiseri, Dareena, Supusson Pengnam, Praneet Opanasopit, et al. "Novel propranolol-loaded gastro-floating 3D-printed devices with zero-order release kinetics." Pharmacia 71 (December 19, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133399.

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Currently, fused deposition modeling (FDM) is a 3D printing technology that has been most widely used to develop innovative drug delivery approaches for overcoming the limitations of oral drug administration. Propranolol has a short plasma half-life and is well soluble in acidic environments. Thus, this study aimed to develop a gastro-floating 3D printed device (GFD) to sustain the release of propranolol in the stomach as a gastro-retentive drug delivery system. The polylactic acid (PLA) was selected to fabricate the GFD. An air chamber was included in the interior construction of the GFD design for buoyancy. The number of open channels on the side wall of GFD was modified to regulate release. The propranolol gel formulation was composed of a mixture of propranolol and polyvinylpyrrolidone (PVP) at the weight ratio of 6:5 and was then loaded into GFDs using a syringe. GFD exhibited a floating ability of more than 24 h with low standard deviation (SD) values of weight variation and shape dimension. The propranolol release from GFD shows sustained release properties in the simulated gastric environment without lag time. The 4 and 5 channels of GFD exhibited sustained drug release for 6 h. In addition, the duration of sustained release for 8 h was achieved from the GFD with 2 and 3 channels. The kinetic release of propranolol from GFDs was the best fit with zero-order. Thus, the GFDs could be designed to control the drug release according to each patient, which has the potential for applying personalized gastro-retentive drug delivery in various medications. Graphical abstract

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27

Jaiseri, Dareena, Supusson Pengnam, Praneet Opanasopit, et al. "Novel propranolol-loaded gastro-floating 3D-printed devices with zero-order release kinetics." Pharmacia 71 (December 19, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133399.

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Currently, fused deposition modeling (FDM) is a 3D printing technology that has been most widely used to develop innovative drug delivery approaches for overcoming the limitations of oral drug administration. Propranolol has a short plasma half-life and is well soluble in acidic environments. Thus, this study aimed to develop a gastro-floating 3D printed device (GFD) to sustain the release of propranolol in the stomach as a gastro-retentive drug delivery system. The polylactic acid (PLA) was selected to fabricate the GFD. An air chamber was included in the interior construction of the GFD design for buoyancy. The number of open channels on the side wall of GFD was modified to regulate release. The propranolol gel formulation was composed of a mixture of propranolol and polyvinylpyrrolidone (PVP) at the weight ratio of 6:5 and was then loaded into GFDs using a syringe. GFD exhibited a floating ability of more than 24 h with low standard deviation (SD) values of weight variation and shape dimension. The propranolol release from GFD shows sustained release properties in the simulated gastric environment without lag time. The 4 and 5 channels of GFD exhibited sustained drug release for 6 h. In addition, the duration of sustained release for 8 h was achieved from the GFD with 2 and 3 channels. The kinetic release of propranolol from GFDs was the best fit with zero-order. Thus, the GFDs could be designed to control the drug release according to each patient, which has the potential for applying personalized gastro-retentive drug delivery in various medications. Graphical abstract

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28

Parimi, Ravi, Rama Rao Vadapalli, and K. E. Pravallika. "Development and Optimization of Wax Matrix Tablets of Levetiracetam for Zero-order Controlled Release." International Journal of Pharmaceutical Sciences and Drug Research 13, no. 03 (2020): 246–52. http://dx.doi.org/10.25004/ijpsdr.2021.130302.

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The major objective of this work was to develop once-daily, extended-release tablets with zero-order drug release for levetiracetam using the wax matrix as the release retarding element. Extending drug release for highly water-soluble drugs is always a challenge. In this work, levetiracetam, a highly soluble drug, was chosen for which extended-release matrix tablets were developed using different waxes such as Compritol ATO 888, Imwitor 491, tristearin, and cetylpalmitateas rate controlling materials taken in different amounts. PEG 6000 was used to regulate water availability inside the wax matrix, and lactose was used as a pore-forming agent to aid the release of the drug from the wax matrix. Tablets were prepared by embedding the drug into the molten wax, followed by solidification, sieving, mixing with other excipients, and finally compression. The prepared tablets were tested for hardness, tensile strength, friability, drug content, and drug release studies. Type of wax, amount of wax, and PEG 6000 were optimized to achieve controlled drug release for about 24 hours. All the tablets showed good tensile strength in the range of 0.59–0.70 N/mm2, packing fraction in the range of 0.85–0.92, and friability in the range of 0.42–55%, indicating their solid physical integrity. The drug release studies indicated that the tablets prepared with tristearin showed better control among the waxes taken. The tablets containing 150mg of tristearin, 50mg of PEG 6000, and 50 mg of lactose showed controlled drug release for 24 hours with the zero-order release.

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29

Gierszewska, Magdalena, Jadwiga Ostrowska-Czubenko, and Ewelina Chrzanowska. "CHARACTERISTICS OF ASCORBIC ACID RELEASE FROM TPP-CROSSLINKED CHITOSAN/ALGINATE POLYELECTROLYTE COMPLEX MEMBRANES." Progress on Chemistry and Application of Chitin and its Derivatives XXIII (September 10, 2018): 76–87. http://dx.doi.org/10.15259/pcacd.23.007.

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Chitosan/alginate polyelectrolyte complex membranes (Ch/Alg) additionally cross-linked with tripolyphosphate (TPP) and containing ascorbic acid (AA) were prepared. The dynamic swelling behaviour of Ch/Alg/TPP and ascorbic acid release from the membrane were characterised in different buffer solutions. It has been found that the pH of the buffer solution affects the swelling and release behaviour of AA. Ascorbic acid release, observed over a period of 360 min, exhibited a biphasic pattern, characterised by a fast initial burst release, followed by a slow, sustained release. Different mathematical models were used to study the kinetics and transport mechanism of AA from Ch/Alg/TPP hydrogels. Drug release data were fitted to the zero order kinetic model and first order kinetic model. To characterise the drug mechanism, the release data were fitted to the Higuchi and Korsmeyer-Peppas equations. The initial burst AA release followed zero order kinetics and was quasi-Fickian in nature. The second step of AA release followed first order kinetics.

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30

Khoder, Mouhamad, Henry Gbormoi, Ali Ryan, Ayman Karam, and Raid Alany. "Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads." Pharmaceutics 11, no. 2 (2019): 83. http://dx.doi.org/10.3390/pharmaceutics11020083.

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In this study, bovine serum albumin (BSA) and alginate (ALG) conjugates were synthesized by the Maillard reaction in order to evaluate their potential to develop controlled release drug delivery systems. The progress of the Maillard reaction was evidenced using ultraviolet (UV) absorbance, determination of BSA remaining free amino groups, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). BSA-ALG conjugates possessed enhanced and tunable viscosity, foamability and foam stability. Foam generated from BSA-ALG conjugate solution was used to prepare floating gastroretentive calcium ALG beads. Unlike traditional ALG beads, BSA-ALG foam beads were able to float and sustain the ciprofloxacin (CIP) release in gastric medium. Interestingly, intestinal beads made of ALG, BSA-ALG physical mixture and BSA-ALG conjugate resulted in different release rates and orders of indomethacin (IND) in simulated intestinal fluids; while beads based on a physical mixture of BSA-ALG resulted in a first order sustained release profile, both systems based on ALG and BSA-ALG conjugate displayed zero order sustained release profiles with IND being released at a slower rate from the conjugate beads.

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Ranjeet, Singh* Dr. Amit Chaudhary. "Coating Techniques for Sustained Release Pellet Dosage Forms: Strategies for Achieving Zero-Order Release Kinetics." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 477–83. https://doi.org/10.5281/zenodo.15334874.

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The pursuit of zero-order drug release has become a key objective in the design of sustained release (SR) oral dosage forms, aiming to maintain constant plasma drug levels and enhance therapeutic efficacy. Pellet-based multiparticulate systems offer significant advantages in controlled drug delivery, including uniform distribution in the gastrointestinal tract, reduced risk of dose dumping, and flexible formulation design. Central to achieving desired release profiles is the application of functional polymer coatings that regulate drug diffusion. This review comprehensively explores coating techniques for sustained release pellets, with a particular focus on strategies that enable zero-order kinetics. It covers the principles of pelletization, polymer selection, coating technologies, and formulation innovations. Special emphasis is placed on multi-layer coating designs, the use of pore-forming agents, and osmotically driven mechanisms. Recent advances such as nanocoating, 3D printing, and Quality by Design (QbD) approaches are also discussed. The review concludes with an overview of current challenges and future directions in achieving consistent, predictable, and patient-centric drug delivery through advanced coating technologies.

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Rajeswari, Saripilli, Sravya Kudamala, and Kollapalli Venkata Ramana Murthy. "DEVELOPMENT, FORMULATION AND EVALUATION OF A BILAYER GASTRIC RETENTIVE FLOATING TABLETS OF RANITIDINE HCL AND CLARITHROMYCIN USING NATURAL POLYMERS." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 9 (2017): 164. http://dx.doi.org/10.22159/ijpps.2017v9i9.20290.

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Objective: Bilayer gastric retentive floating tablets (BGRFT) with ranitidine HCl and clarithromycin using natural gums have been developed to prolong the gastric residence time and increase drug bioavailability. Literature review revealed no published studies on the present study.Methods: Immediate release (IR) layer prepared by using different diluents and super disintegrants like sodium starch glycolate, crosscarmellose sodium and crospovidone. Controlled released (CR) layer prepared by using neem gum, damar gum and copal gum. Prepared tablets were evaluated for in vivo and in vitro buoyancy, in vitro dissolution studies and fourier transformation-infrared spectroscopy (FTIR). Drug release was evaluated with zero and first order for release kinetics, Higuchi, Hixson-Crowell erosion models for release mechanism.Results: Prepared IR layer followed first order rate kinetics and CR layer followed zero order rate kinetics with non-Fickian diffusion mechanism. BGRFT also showed similar results as that of the individual layer. Optimized formulations were characterized by FTIR studies and found no interactions between drug and polymer.Conclusion: The results demonstrate the feasibility of the model in the development of BGRFT. BGRFT enhanced the drug release and finally the bioavailability of clarithromycin when compared with commercial tablet (Biomycin 250). The present study could establish the suitability of neem gum as CR polymer in the design of BGRFT.

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33

Reddy, Penaka Nomika, P. Venkata Anudeep, Venugopalaiah Penabaka, and Yadala Prapurna Chandra. "Formulation and evaluation of hydrogel beads of flecainide." International Journal of Experimental and Biomedical Research 3, no. 4 (2024): 59–67. https://doi.org/10.26452/ijebr.v3i4.669.

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This study focuses on creating and assessing hydrogel beads containing Flecainide. Hydrogels are polymer networks that absorb and retain significant amounts of water. Within this network, hydrophilic groups become hydrated in aqueous environments, forming a hydrogel structure. The primary goal was to evaluate the formulation of hydrogel beads with Flecainide. Preliminary studies, including solubility and UV analysis, confirmed the formulation's requirements. FTIR spectra indicated no interaction between Flecainide and the polymers, suggesting that the distribution of Flecainide within the beads was appropriate and within acceptable limits.Additionally, the study demonstrated that as the polymer concentration increases, the amount of medication released decreases. The Flecainide hydrogel beads exhibited controlled and extended drug release in vitro. The dissolution data for the optimal formulation (F12) were analyzed using three kinetic models: the Higuchi and Korsmeyer-Peppas equations, zero-order, and first-order kinetics. The r² value for the optimized formulation F12 is 0.974, indicating compliance with zero-order release kinetics. Furthermore, the Korsmeyer-Peppas analysis supports the mechanism of drug release. For formulation F12, the "n" value is 1.021, indicating a supercase transport mechanism.

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34

D. Shivhare, Umesh, Vikrant P. Dorlikar, Kishore P. Bhusari, Vijay B. Mathur, and Bhiku N. Mirani. "Effect of Polymeric Compositions on Pharmacotechnical Properties of Carvedilol Transdermal Film." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (2009): 457–64. http://dx.doi.org/10.37285/ijpsn.2009.2.1.10.

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Transdermal films of carvedilol were prepared by using Eudragit RL100 (ERL100) either alone or in combination with Eudragit RS100 (ERS100), hydroxypropyl methylcellulose K 15 LV (HPMC), and ethyl cellulose (EC). The drug release was extended over a period of 24 h from all formulations. The formulation A5 showed 98.33 cumulative % drug releases in 24 h and followed zero order kinetics. The drug transport mechanism was observed to be Fickian. The cumulative % drug diffused through artificial permeation membrane (cellophane A 393) from same formulation was 100.52 % over a 12 h. The mechanism of dug release was governed by Peppas model and the drug diffusion rate followed zero order kinetics. The formulation A5 comprising of polymers ERL 100, ERS 100, EC and HPMC in 7:1:1:1 ratio fulfills the requirement of good TDDS.

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35

Urbaniak, Tomasz, Yauheni Milasheuski, and Witold Musiał. "Zero-Order Kinetics Release of Lamivudine from Layer-by-Layer Coated Macromolecular Prodrug Particles." International Journal of Molecular Sciences 25, no. 23 (2024): 12921. https://doi.org/10.3390/ijms252312921.

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To reduce the risk of side effects and enhance therapeutic efficiency, drug delivery systems that offer precise control over active ingredient release while minimizing burst effects are considered advantageous. In this study, a novel approach for the controlled release of lamivudine (LV) was explored through the fabrication of polyelectrolyte-coated microparticles. LV was covalently attached to poly(ε-caprolactone) via ring-opening polymerization, resulting in a macromolecular prodrug (LV-PCL) with a hydrolytic release mechanism. The LV-PCL particles were subsequently coated using the layer-by-layer (LbL) technique, with polyelectrolyte multilayers assembled to potentially modify the carrier’s properties. The LbL assembly process was comprehensively analyzed, including assessments of shell thickness, changes in ζ-potential, and thermodynamic properties, to provide insights into the multilayer structure and interactions. The sustained LV release over 7 weeks was observed, following zero-order kinetics (R2 > 0.99), indicating a controlled and predictable release mechanism. Carriers coated with polyethylene imine/heparin and chitosan/heparin tetralayers exhibited a distinct increase in the release rate after 6 weeks and 10 weeks, respectively, suggesting that this coating can facilitate the autocatalytic degradation of the polyester microparticles. These findings indicate the potential of this system for long-term, localized drug delivery applications, requiring sustained release with minimal burst effects.

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H. Takahashi, Suelen, Luiz M. Lira, and Susana I. Córdoba de Torresi. "Zero-Order Release Profiles from A Multistimuli Responsive Electro-Conductive Hydrogel." Journal of Biomaterials and Nanobiotechnology 03, no. 02 (2012): 262–68. http://dx.doi.org/10.4236/jbnb.2012.322032.

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Madgulkar, Ashwini, Shivajirao Kadam, and Varsha Pokharkar. "Development of trilayered mucoadhesive tablet of itraconazole with zero-order release." Asian Journal of Pharmaceutics 2, no. 1 (2008): 57. http://dx.doi.org/10.4103/0973-8398.41568.

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NISHI, TSUGIO. "Compartment model for slow release preparations accompanied with zero order dissolution." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 18, no. 1 (1987): 53–54. http://dx.doi.org/10.3999/jscpt.18.53.

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Zhi, Bin, and Yu Mao. "Vapor-Deposited Nanocoatings for Sustained Zero-Order Release of Antiproliferative Drugs." ACS Applied Bio Materials 3, no. 2 (2020): 1088–96. http://dx.doi.org/10.1021/acsabm.9b01044.

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Zhao, Ya-nan, Qingping Yuan, Chong Li, Ying Guan, and Yongjun Zhang. "Dynamic Layer-by-Layer Films: A Platform for Zero-Order Release." Biomacromolecules 16, no. 7 (2015): 2032–39. http://dx.doi.org/10.1021/acs.biomac.5b00438.

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Yu, Deng-Guang, Xiao-Yan Li, Xia Wang, Wei Chian, Yao-Zu Liao, and Ying Li. "Zero-order drug release cellulose acetate nanofibers prepared using coaxial electrospinning." Cellulose 20, no. 1 (2013): 379–89. http://dx.doi.org/10.1007/s10570-012-9824-z.

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Vyavahare, N. R., M. G. Kulkarni, and R. A. Mashelkar. "Matrix systems for zero-order release: facile erosion of crosslinked hydrogels." Polymer 33, no. 3 (1992): 593–99. http://dx.doi.org/10.1016/0032-3861(92)90737-h.

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Zhan, Xiaoping, Sijing Chen, Guochun Tang, and Zhenmin Mao. "Two new types of copolymer membranes controlling clonidine zero-order release." Journal of Applied Polymer Science 106, no. 5 (2007): 3016–22. http://dx.doi.org/10.1002/app.26954.

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Das, Utpal, Shimul Halder, Abul Kalam Lutful Kabir, Harun Or Rashid, and Abu Shara Shamsur Rouf. "Development and in vitro Evaluation of Sustained Release Matrix Tablets of Indapamide from Methocel® K15 MCR and K100 LVCR." Dhaka University Journal of Pharmaceutical Sciences 10, no. 2 (2012): 87–92. http://dx.doi.org/10.3329/dujps.v10i2.11785.

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Indapamide, a low-dose thiazide-type diuretic, is used for the treatment of essential hypertension. In this study, we developed an indapamide sustained release formulation using Methocel K15 MCR (a modified hydroxypropyl methylcellulose), Methocel K100 LVCR (a modified hydroxypropyl methylcellulose), magnesium stearate, talc and starch 1500 by direct compression. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity etc. The tablets were subjected to thickness, weight variation test, hardness, friability and in vitro release studies. The in vitro dissolution study was carried out in the gastric medium (pH 1.3) for first two hours and then in the intestinal medium (pH 6.8) for 22 hours using United States Pharmacopoeia (USP) 22 paddle-type dissolution apparatus. The granules showed satisfactory flow properties, compressibility index etc. All the tablets complied with pharmacopoeial specifications. The results of dissolution studies indicated that the formulation F-5 and F-7 (up to 75.36 % drug release in 12 hours) could extend the drug release up to 12 hours. The drug release patterns were simulated in different kinetic orders such as Zero Order release kinetics, First Order release kinetics, Higuchi release kinetics, Korsmeyer-Peppas release kinetics and Hixson-Crowell release kinetics to assess the release mechanism. From the study we observed that Higuchi release kinetics was the predominant release mechanism than Zero Order and First Order kinetics. The drug release mechanism from the matrix tablets was found to be non Fickian mechanism. DOI: http://dx.doi.org/10.3329/dujps.v10i2.11785 Dhaka Univ. J. Pharm. Sci. 10(2): 87-92, 2011 (December)

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B., Divya* J. Sreekanth D. Satyavati. "FORMULATION AND EVALUATION PARAMETERS OF EXTENDED-RELEASE TABLETS OF ILAPRAZOLE BY USING NATURAL AND SYNTHETIC POLYMERS." Journal of Pharma Research 05, no. 12 (2016): 256–67. https://doi.org/10.5281/zenodo.6413946.

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ABSTRACT Ilaprazole is a Proton Pump Inhibitor (PPI), an anti-acidic drugused in the treatment of dyspepsia, peptic and duodenal ulcer disease, gastroesophageal reflux disease (GERD).Ilaprazole at oral doses of 10 mg has shown higher suppression of gastric acid secretion and more prolonged plasma half-life, and similar safety compared to 20 mg omeprazole. Elimination half-life for Ilaprazole ranged from 4.7 to 5.3 h, Administration of Ilaprazole in an extended-release dosage form would be more desirable by maintaining the plasma drug concentrations at a prolonged period of time. It will be more beneficial in maintaining nocturnal gastric pH<4. The main objective to formulate and evaluate extended-release matrix tablets of Ilaprazole by wet granulation technique by using natural polymers and synthetic polymers. The granules were evaluated by angle of repose, Bulk and Tapped density, Hausner’s ratio, Carr’s index. The tablets were subjected to Thickness, Weight variation, Drug content, Hardness, Friability and In-vitro drug release studies. The Physicochemical properties of tablets were found within the limits. In-vitro dissolution study was carried out for first 2 hrs in 0.1N Hcl and remaining 10 hrs in 6.8 PH Phosphate buffer as a dissolution medium. Based on the results F-21 (Drug: Eudragit RSPO ratio 1:2) formulation was chosen as a best among all the formulations in the point of drug release and mechanism. The release mechanisms were explored and explained with Zero order, First order, Higuchi, Peppas. Keywords: Ilaprazole, wet granulation technique, Eudragit RSPO, Zero-order Kinetics

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Kusum, ,., Avinash Kumar Gupta, Manish Kumar Gupta, and Vijay Sharma. "A Review on Formulation and Evaluation of Sustained Release Tablet of Devilproex Sodium." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 660–62. http://dx.doi.org/10.22270/jddt.v9i4.3067.

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An appropriately designed drug delivery system can be a major step towards solving these two problems. This technique for the drug administration is termed as ‘sustained release’ or ‘controlled release. Drugs with dosage not exceeding 125mg – 325mg are more suited as extended release products in order to limit the size of the delivery system. In the case of soluble matrix the matrix swells or dissolves. These matrices then undergo surface erosion with little or no bulk erosion. Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. One of its most important characteristics is the high gelation velocity and viscosity, which has a significant effect on the release kinetics of the incorporated drug. It was proven that HPMC at high concentration promoted the drug release approaching to a zero-order release kinetic because of its gelation properties Keywords: HPMC, Divalproex sodium, sustained release and zero-order release kinetic

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Cheung, Wing K., B. Michael Silber, and Avraham Yacobi. "Pharmacokinetic Principles in the Design of Immediate-Release Components in Sustained-Release Formulations with Zero-Order Release Characteristics." Journal of Pharmaceutical Sciences 80, no. 2 (1991): 142–48. http://dx.doi.org/10.1002/jps.2600800211.

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V., Viswanath*and D. Anusha. "FORMULATION DEVELOPMENT AND EVALUATION STUDIES IN IN-VITRO OF ECONAZOLE NITRATE TRANSFEROSOMAL GEL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 08 (2019): 15245–56. https://doi.org/10.5281/zenodo.3376716.

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Econazole nitrate is mainly used in the treatment of fungal infections. The basic idea behind the development of such a system is to maintain a sustain release of drug from the dosage form and for target delivery. Econazole nitrate has short half life (4hrs) when Econazole nitrate was formulated as transferosomes, half life can be increased and the desired effect can be obtained. In the research work an attempt was made to formulate and evaluated the transferosomal gel for sustained effect. Estimation of Econazole nitrate was carried out by U.V spectrophotometer at λ max 271.5 nm using water as solvent, which had a good reproducibility and this method was used entire study. Formulations were prepared by using soya lecithin as a lipid polymer and solvent such has ethanol the size of transferosomes, morphology, entrapment efficiency, solubility studies and drug release were evaluated. Entrapment efficiency ranging from 65.45 to 80.11% was obtained. Particle size of transferosomes was found to be in the range of 368 to 931 nm. In 24 hrs the drug release was observed ranging from 79.08% to 88.72%. Drug release from the gel was observed that 79.90%. In order to reduce the probable mechanism of drug from the dosage form, the result of in vitro dissolution studies were fitted to various kinetics equations. When the data subjected to zero order and first order kinetics model, a linear relationship was observed with high R2 values for zero order model as compared to first order model and suggested that the formulations followed zero order sustained release. Key words: Transferosomes, Econazole nitrate, Soya lecithin, Sustain release, Zero order.

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Liao, Yongfang, Zizhen Ye, Meng Qian, et al. "Photoactive NO hybrids with pseudo-zero-order release kinetics for antimicrobial applications." Organic & Biomolecular Chemistry 18, no. 28 (2020): 5473–80. http://dx.doi.org/10.1039/d0ob00564a.

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Park, Jin Su, Myung-Chul Gil, Young Ho Cho, and Gye Won Lee. "Formulation and Dissolution Behavior of a New OROS Tablet containing Sarpogrelate Hydrochloride." Yakhak Hoeji 67, no. 6 (2023): 360–71. http://dx.doi.org/10.17480/psk.2023.67.6.360.

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Sarpogrelate hydrochloride (SGH) is a drug that improves ischemic symptoms such as ulcers, pain, and feeling of cold caused by chronic arterial occlusion, and has a short half-life of 0.6 to 0.8 hours. Also, reference drug (SarpodipilⓇ SR tablet) is affected by drug release depending on pH. To overcome this, the osmotic controlled release oral delivery system (OROS) utilizes push-pull osmotic pump (PPOP) technology that can achieve zero-order drug release over 24 hours by osmotic pressure. OROS tablet is double-layer tablet consisting of a drug layer (L200-PEO) and a push layer (H5,000- PEO). OROS tablet coated with a semi-permeable film has a orifice of a certain size made by a laser drill, so that the drug is released at a constant rate. The dissolution of the OROS tablet was not affected by the amount of sodium chloride in the drug layer and the number of orifice, but was affected by amount of coating, cellulose acetate (CA) : polyethylene glycol 3350 (PEG 3350) ratio and the size of orifice. Accordingly, as the amount of coating increased and PEG 3350 decreased, the dissolution rate decreased. The developed OROS tablet (formulation C), unlike the reference drug, is not affected by pH, showing high similarity factors of 76.0, 86.1, and 91.2 at pH 1.2, pH 4.0, and pH 6.8 when compared to distilled water. In conclusion, we developed OROS tablet containing SGH, showing zero-order release that continuously releases the drug for 24 hours regardless of pH, and confirmed the factors affecting dissolution.

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Journal articles on the topic 'And zero order release'

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