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Dissertations / Theses on the topic 'Androgen deprivation'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 March 2023

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1

Lorch, Robert A. "MicroRNA regulation of prostate cancer desensitization to androgen receptor antagonist drugs during androgen deprivation therapy." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/462.

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The current standard treatment of prostate cancer by androgen deprivation therapy involves using drugs such as bicalutamide (Casodex) to antagonistically block androgen receptors that are normally present within prostate cells. Usually, the therapy is successful in the short run at limiting the growth of prostate cancer. However, in virtually all cases tumors begin to grow aggressively again after several months of treatment and new therapies must be started. The mechanism by which these prostate cells transform from androgen sensitive to androgen independent and anti-androgen resistant is unc

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2

Galvão, Daniel Abido. "Resistance exercise in men receiving androgen deprivation therapy for prostate cancer." Connect to thesis, 2006. http://portal.ecu.edu.au/adt-public/adt-ECU2006.0046.html.

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3

Gilbert, Stephen E. "Cardiovascular health in men on androgen deprivation therapy for prostate cancer." Thesis, Sheffield Hallam University, 2013. http://shura.shu.ac.uk/20685/.

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Androgen deprivation therapy (ADT) is a cornerstone treatment option for men with metastatic or locally advanced prostate cancer, however, treatment with ADT has been associated with increased incidence of adverse cardiovascular events. Strategies to investigate and monitor cardiovascular risk, as well as to reduce such treatment-related morbidity are urgently required in this population. Study 1 of this thesis investigated the differences in endothelial function between men with advanced prostate cancer treated with ADT and matched controls using a case-control design. Flow-mediated dilatatio

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4

Giannantoni-Ibelli, Gina. "Association Between Androgen Deprivation Therapy for Prostate Cancer and Alzheimer's Disease." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/6206.

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Alzheimer's disease (AD) is the most common progressive, neurodegenerative disease and form of dementia. The hallmarks of AD are extracellular accumulation of amyloid beta protein, resulting in neuritic, senile plaques and intracellular accumulation of tau protein. AD mainly arises from imbalance of amyloid beta protein production and its clearance in the brain. Testosterone modulates production of amyloid beta protein by decreasing its accumulation. Prostate cancer remains a substantial public health challenge in the United States. While androgen deprivation therapy (ADT) is an effective trea

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5

Galvao, Daniel A. "Resistance exercise in men receiving androgen deprivation therapy for prostate cancer." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2006. https://ro.ecu.edu.au/theses/64.

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This thesis encompasses two literature reviews (chapter 2 & 3) and two experimental chapters (4 and 5) examining the available literature on exercise and cancer, resistance training and its anabolic responses in older men and women, the side effects of Androgen Deprivation Therapy (ADT) for prostate cancer and finally, the role of resistance exercise as a clinical intervention to counteract such changes as an adjuvant therapy.

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6

Joshee, Paras. "Cognition in prostate cancer patients before undergoing androgen deprivation therapy and elderly males." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8853/.

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Deleterious cognitive effects of testosterone deprivation in prostate cancer (PC) patients undergoing androgen deprivation therapy have been reported. However, due to methodological limitations of past research, there is mixed consensus of the cognitive domains affected. The current study therefore aimed to assess cognition before ADT through a comprehensive battery of cognitive and neuroimaging investigations which previous undertakings have lacked. A cross sectional study of 30 ageing PC patients before ADT and 29 age and intelligence matched healthy controls underwent neuropsychological and

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Sarkar, Phoebe Lorraine. "Characterizing the role of insulin signalling in advanced prostate cancer." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/110524/2/Phoebe_Lorraine_Sarkar_Thesis.pdf.

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The majority of prostate cancer patients receiving hormone therapy become insulin resistant and studies show this metabolic dysfunction is associated with more rapid treatment failure, yet the effect of insulin on prostate cancer is not fully known. This thesis discovered the mechanisms by which insulin increases the propensity of prostate cancer cells to migrate which is required for cancer cells to disseminate and metastasise, giving a possible explanation for the more aggressive disease in prostate cancer patients with insulin resistance. The results provide a strong rationale for specifica

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8

Mennen-Winchell, Lori J. "Self-reported exercise and risk of osteoporosis in prostate cancer patients receiving androgen deprivation therapy." Thesis, Loma Linda University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3721215.

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<p> Prostate cancer is stimulated to grow in response to testosterone. Androgen deprivation therapy (ADT) leads to chemical castration and suppression of prostate cancer cell production. Testosterone levels less then 300ng/ml decreases bone mineral density and could result in osteoporosis. Studies have shown that during the first year of ADT, fracture risk, mainly in hips and spine increases about 50%. In men, 40% of hip fractures result in death. Exercise may reduce the risk of osteoporosis and thus contribute to the prevention of hip and other fractures. There is limited data regarding whet

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9

Shah, Syed Imran Ali. "Assessment of systemic effects of sex hormone alterations in androgen deprivation therapy for prostate cancer." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/42883.

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Sex hormonal variations cause bodily changes reflecting their systemic functions. This project was designed to define the influence of sex hormones on systemic function in men with prostate cancer (PC) receiving contemporary androgen deprivation therapy (ADT) with luteinising hormone-releasing hormone agonists (LHRHa). LHRHa induced suppression of sex hormones results in multiple serious toxicities of which the cognitive, skeletal and psychosocial aspects were addressed in this project. Acute castration appears to cause cognitive problems in some men with PC. In order to identify the neuropath

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10

Wiens, Kristin Patricia. "Dietary risk factors for bone loss among men undergoing androgen deprivation therapy for the treatment of prostate cancer." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/21737.

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Androgen deprivation therapy (ADT) is the preferred mode of treatment for patients with recurrence of prostate cancer (PC) following definitive treatment and locally advanced disease. With more men commencing ADT earlier in the treatment trajectory and for longer duration, the side effects of ADT are becoming more prevalent and of greater concern to clinicians. ADT can have serious adverse effects on bone mineral density (BMD) and metabolism, leading to the development of osteopenia or osteoporosis. This study was a cross-sectional investigation of dietary risk factors for bone loss, particula

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11

Chaplow, Zachary Lewis. "Effects of a Lifestyle Intervention on Change in Body Composition in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523462399213986.

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12

Ovtcharov, Slav. "Impact of TMPRSS2-ERG fusion gene on prostate cancer cell response to chemotherapy, radiotherapy and androgen deprivation therapy." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:f30bf48d-fff5-49e7-8258-107a500c8752.

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Many aspects of the mechanisms by which prostate cancer (PCa) progresses from being a confined tumour to advanced metastatic and castration-resistant disease remain unclear. The aim of this study is to evaluate in vitro the potential role of the fusion gene TMPRSS2-ERG in the response of PCa cells to ionising radiation (IR) and androgen deprivation therapy (ADT). This research focused on assessing the presence of the TMPRSS2-ERG transcript across various PCa cell lines and identifying any correlation between the TMPRSS2-ERG transcript and other genes, particularly genes related to DNA damage r

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13

Chiu, Helen Hoi-Lun. "Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation by NF-κB in prostate cancer cells". Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31584.

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Androgen deprivation therapy is an efficacious treatment for advanced prostate cancer (CaP) by inducing apoptosis of prostate cells. Despite the initial effectiveness of this systemic therapy, the cancer will inevitably recur and progress to an androgen-independent stage. The molecular mechanism by which some CaP cells may bypass the cell death induced by androgen deprivation is unclear. Emerging studies have highlighted the role of the inhibitor of apoptosis protein (lAP) family members in conferring an enhanced ability of malignant cells to survive in conditions normally resulting in cell de

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14

Rhee, Handoo V. "Androgen deprivation therapy (ADT), metabolic syndrome and metastatic prostate cancer: In vivo and in vitro assessments of effects of metformin." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/118290/2/Handoo%20Rhee%20Thesis.pdf.

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This thesis describes a translational research approach to identifying a cancer mechanism driven by metabolic syndrome. It examines the impact of androgen deprivation therapy, its association with metabolic syndrome and prostate cancer progression, and the therapeutic and metabolic benefits of adjuvant metformin. The study investigates with a randomized placebo controlled clinical trial, with characterization of the molecular mechanism of metformin in vitro using conditions to mimic physiological hormonal milieu.

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15

Winters, Erin. "Hot flashes in men with prostate cancer : prevalence, severity, and psychosocial correlates." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001632.

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16

Blood, Paul. "A population-based analysis of the risk of hip fracture in men with prostate cancer exposed to radiation and androgen deprivation therapy." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2390.

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Prostate cancer is frequently diagnosed in elderly men and, despite the largely unproven survival benefits of treatment, the majority receive treatment. Treatment options include surgery, radiation, and/or androgen deprivation therapy (ADT). Risks associated with treatment include hip fracture. Current understanding suggests that hip fracture is a frequent cause of morbidity and mortality in the elderly, and both radiation treatment and ADT can increase the risk of hip fracture. It is important to understand these risks so they can be minimized and the morbidity of treatment reduced. The obje

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17

Edmunds, Kim. "Cost-effectiveness of exercise medicine for prostate cancer." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2021. https://ro.ecu.edu.au/theses/2405.

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Background Androgen deprivation therapy (ADT) is associated with numerous adverse effects that impact on quality of life and contribute further to the cost burden of prostate cancer (PCa) via treatment and supportive care. Exercise medicine is effective in slowing PCa progression, reversing treatment adverse effects and improving quality of life and survival of patients, however, no economic analyses have been conducted to determine whether exercise is cost-effective in this population. Objectives Firstly, to examine the adverse effects of ADT for PCa and the evidence supporting the use of exe

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18

Dinh, Kathryn Tindell. "An Exploration of Risk Stratification for Active Surveillance and Androgen Deprivation Therapy Side Effects for Prostate Cancer Utilizing Data From the Surveillance, Epidemiology, and End Results Database." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:27007753.

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Part 1: Occult high-risk disease in clinically low-risk prostate cancer patients: Incidence and clinical predictors from SEER data Objective: First, to determine the incidence of pathologic upgrading and upstaging for contemporary, clinically low-risk patients and identify predictors of having occult, advanced disease to inform selection of patients for active surveillance. We will further consider the differing risk of upgrading at prostatectomy between clinically low-risk patients with ≥50% biopsy cores positive and other prostate cancer patients. Methods: For the first portion of the study

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19

Hammerer, Peter G., and Manfred P. Wirth. "Health-Related Quality of Life in 536 Long-Term Prostate Cancer Survivors after Treatment with Leuprorelin Acetate: A Combined Retrospective and Prospective Analysis." Karger, 2018. https://tud.qucosa.de/id/qucosa%3A70627.

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Introduction: We investigated the health-related quality of life (HRQoL) of long-term prostate cancer patients who received leuprorelin acetate in microcapsules (LAM) for androgen-deprivation therapy (ADT). Methods: The observational study was carried out by 30 office-based German urologists in 536 prostate cancer (PCa) patients treated for ≥5 years with LAM and in 116 patients of an age-matched control group (CG). Data on HRQoL and health status was collected prospectively using validated questionnaires QLQ-C30, QLQ-PR25 and Karnofsky Index. Data on effectiveness (clinical response, prostate

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20

Bousset, Laura. "Cancer de la prostate et mécanismes de résistance à la castration : étude du rôle des récepteurs nucléaires LXR." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAS016.

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Les formes avancées du cancer de la prostate sont classiquement traitées par hormonothérapie. Malheureusement, la plupart des patients, répondant initialement à la privation androgénique, font l’expérience d’une reprise de la croissance tumorale sous traitement qui progresse inévitablement vers un stade létal de la pathologie, le cancer de la prostate résistant à la castration (CRPC). Les altérations du métabolisme lipidique représentent une caractéristique clé des cellules tumorales prostatiques. Parmi ces anomalies, les tumeurs prostatiques accumulent de manière excessive du cholestérol. D

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21

McKenzie, Ian Robert. "The role of insulin in advanced prostate cancer." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/50662/1/Ian_McKenzie_Thesis.pdf.

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Advanced prostate cancer is a common and generally incurable disease. Androgen deprivation therapy is used to treat advanced prostate cancer with good benefits to quality of life and regression of disease. Prostate cancer invariably progresses however despite ongoing treatment, to a castrate resistant state. Androgen deprivation is associated with a form of metabolic syndrome, which includes insulin resistance and hyperinsulinaemia. The mitogenic and anti-apoptotic properties of insulin acting through the insulin and hybrid insulin/IGF-1 receptors seem to have positive effects on prostate tumo

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22

Maldonado, Pijoan Javier. "Escalada de dosis de radioterapia en combinación con deprivación androgénica en el tractamiento del cáncer de próstata de riesgo intermedio y alto." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/665829.

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En la última década, han surgido dos conceptos para mejorar el control local y los resultados para pacientes con cáncer de próstata localizado, a saber, la escalda de la dosis con nuevas tecnologías de radioterapia y el tratamiento combinado con la deprivación androgénica. Los estudios institucionales y multiinstitucionales de intensificación de la dosis de radioterapia en cáncer de próstata, han demostrado consistentemente una mejora en la supervivencia libre de enfermedad bioquímica y control local a medida que se administra una dosis creciente de radiación (≥75.6 Gy vs. 70.0 Gy). Esta mejo

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23

Scailteux, Lucie-Marie. "Evaluation de la sécurité d’emploi des médicaments modulant les androgènes dans les maladies prostatiques, une approche pharmaco-épidémiologique." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B006.

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Contexte : En France, le cancer de la prostate est une maladie fréquente de l’homme âgé et la première cause de cancer. Il est associé à une survie de 70 % à 10 ans. Différentes options thérapeutiques sont recommandées dans la prise en charge de ce cancer, parmi lesquelles l’hormonothérapie (ou thérapie par déprivation d’androgène, ADT). Le profil de sécurité de l’hormonothérapie et des différentes modalités qui la composent est remis en question depuis le milieu des années 2000 avec plusieurs auteurs ayant évoqué un sur-risque cardiovasculaire comparativement aux patients non traités. Les rés

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Johansson, Eva. "Quality of Life and Functional Outcomes in Men with Localized Prostate Cancer." Doctoral thesis, Uppsala universitet, Medicinska fakulteten, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158094.

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Quality-of-life and functional outcomes are important in the choice of treatment for men with localized prostate cancer. These issues were investigated in the present thesis. All living 400 men randomized to radical prostatectomy or watchful waiting from 1989 to 1999 in the Scandinavian Prostate Cancer Group Number 4 (SPCG-4) were included. An additional 281 men compromised an age-matched control group. Physical symptoms, symptom-induced stress, sense of well-being and self-assessed quality of life were evaluated by a study-specific questionnaire. Results showed that prostate cancer men, regar

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Klaff, Rami. "Disease-Specific Survival in Prostate Cancer Patients : Results from the Scandinavian Prostate Cancer Group (SPCG) Trial No. 5 and Regional Cancer Register Data." Doctoral thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132385.

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Introduction Prostate cancer (PCa) is the most common cancer among men in Sweden. The clinical course varies considerably, which makes it difficult to predict the prognosis in the individual case. In order to explore the early as well as the late course of the disease, large study groups and population-based cohorts are necessary. Aims To explore factors that influence the long-term outcome of men with low-risk tumours in a population-based register, to predict the long-term course, and to assess the mortality rate for men with prostate cancer (Paper I) To analyse long-term outcome and to inve

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Regis, Plácido Lucas. "Valor de la testosterona libre en el diagnóstico y seguimiento del cáncer de próstata." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/386533.

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Desde que Huggins y Hodges en 1941 describieran la hormono dependencia del cáncer de próstata, la elevación de los niveles de testosterona en suero ha sido relacionada con la carcinogénesis prostática. Sin embargo, el papel de la testosterona en la neoplasia de la próstata es controvertida. La testosterona en suero se encuentra unida mayoritariamente a la hormona transportadora de esteroides sexuales y a la albúmina, y solamente, entre un 1 y 2% circula en forma de testosterona libre, isoforma biológicamente activa. Los pacientes con cáncer de próstata avanzado sometidos a terapia de de

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Servián, Vives Pol. "Clinical significance of prostatic proliferative inflammatory atrohpy." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/386532.

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La atrofia proliferativa inflamatoria (PIA) se ha relacionado con la carcinogénesis prostática. El epitelio proliferativo en la lesión PIA podría progresar a neoplasia intraepitelial prostática de alto grado (HGPIN), adenocarcinoma o ambos. Sin embargo, se conoce poco acerca del significado clínico de detectar PIA en biopsias prostáticas (BPs) negativas. Se realizó una revisión de la literatura actual(1rartículo). Objetivos: 1)Determinar la incidencia de PIA en BPs con y sin cáncer de próstata (CaP) y en prostatectomías radicales (PRs), su asociación con HGPIN y agresividad tumoral(2ºartículo

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Wang, Wei-Na, and 王維那. "A cost-outcome analysis of androgen deprivation therapy and androgen deprivation therapy combine radiotherapy for locally advanced prostate cancer." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/28097547706589051855.

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碩士<br>高雄醫學大學<br>醫務管理學研究所碩士在職專班<br>99<br>Purpose 1. Comparison of androgen deprivation therapy to androgen deprivation therapy with radiation therapy at the patient characteristics and hospital characteristics of the different medical treatment. 2. Comparison of androgen deprivation therapy to androgen deprivation therapy with radiation therapy at the cost difference. 3. Comparison of combined androgen deprivation therapy and differences in the effect of radiation therapy. 4. Androgen deprivation therapy to androgen deprivation therapy with radiation therapy Comparison of cost-effectiveness an

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Wilke, Derek R. "Preferences for short- versus long term androgen deprivation in prostate cancer survivors." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=362404&T=F.

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Hwang, Olivia Rachel, and 黃珞薇. "Risk of Comorbidities in Advanced Prostate Cancer Patients Receiving Androgen Deprivation Therapy." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/cw8k6w.

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Maturi, M. Brigida. "Cost-effectiveness of Intermittent versus Continuous Androgen Deprivation Therapy in Advanced Prostate Cancer." Thesis, 2012. http://hdl.handle.net/1807/33443.

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Background: Androgen deprivation therapy (ADT) has known adverse effects (AEs). Intermittent (INT) ADT may reduce AEs, improve quality of life, and lower costs compared to continuous (CONT) treatment. Objective: To evaluate the cost-effectiveness of INT vs CONT ADT in men with advanced prostate cancer. Methods: A lifetime Markov individual simulation model was developed to evaluate the incremental cost per quality adjusted life month (QALM) of INT vs CONT ADT. Results: INT dominated CONT ADT (mean total costs $94,460 vs $109,431; mean total QALMs 47.0 vs 46.4). INT ADT resulted in less time on

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Chiang, Szu-Yu, and 姜思羽. "Assessing Effectiveness and Safety of Androgen Deprivation Therapy in Patients with Prostate Cancer in Taiwan." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/77091402812039115846.

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碩士<br>高雄醫學大學<br>藥學系臨床藥學碩士班<br>105<br>Background and objective: Hormone therapy, known as androgen deprivation therapy (ADT), is one of the treatment options for prostate cancer patients. ADT includes surgical bilateral orchiectomy and medical therapy. In several studies, ADT was found to increase the risk of diabetes and cardiovascular disease, including myocardial infarction and stroke. Furthermore, there are few studies evaluating the effectiveness and safety of ADT in Taiwanese population. Our study aimed to evaluate the effectiveness and safety of medical androgen deprivation therapy in pa

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Geng, Jiun-Hung, and 耿俊閎. "Association analysis of Wnt pathway gene on clinical outcomes in prostate cancer patients receiving androgen-deprivation therapy." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/80712294420825500230.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>103<br>Approximately 10% to 20% of newly diagnosed prostate cancer patients presented with advanced disease and androgen deprivation therapy (ADT) is the most common first-line treatment for advanced prostate cancer. However, many patients on ADT progress to castration-resistant prostate cancer (CRPC) within 2–3 years. Once CRPC develops, patient’s life expectancy is approximately 16–18 months. A few parameters, including prostate specific antigen (PSA) doubling time, PSA nadir, PSA level at ADT initiation, clinical stage and Gleason score, have been reported as use

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Murphy, Robyn Marie. "THE PHYSIOLOGICAL AND PSYCHOSOCIAL EFFECTS OF A 16-WEEK COMBINED AEROBIC AND RESISTANCE EXERCISE PROGRAM IN MEN RECEIVING ANDROGEN DEPRIVATION THERAPY FOR PROSTATE CANCER." 2011. http://hdl.handle.net/10222/13338.

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Objectives: Men who receive androgen deprivation therapy (ADT) for prostate cancer (PCa) are at risk of several adverse effects that can be detrimental to both their physical and mental health. Common adverse effects include weight gain, muscle wasting, cardiovascular morbidity, fatigue and impaired quality of life (QOL). This study tested whether a combined aerobic and resistance exercise program can alleviate some of these symptoms in men receiving ADT. Design: Men with PCa, aged 50-80 years, receiving ADT were recruited to participate in this prospective randomized controlled trial. Subject

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Cordia, Igor [Verfasser]. "Docetaxel in the management of PSA progression following primary androgen deprivation for prostate cancer / vorgelegt von Igor Cordia." 2009. http://d-nb.info/996274405/34.

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Wu, Fang-Jen, and 吳芳仁. "Investigation of Fall Risk and a Herpes Zoster Attack in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8p9gy3.

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Huang, Yu-Ting, and 黃郁庭. "Evaluation of Health-related Quality of Life of Androgen Deprivation Therapy in Patients with Prostate Cancer in Taiwan." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2cyuw3.

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碩士<br>高雄醫學大學<br>藥學系臨床藥學碩士班<br>106<br>Background and study aim: Prostate cancer (PC) is one of the common cancer among Taiwanese male. Current treatments, such as radical prostatectomy (RP), radiation therapy (RT), androgen deprivation therapy (ADT), and chemotherapy, for PC can provide quite long-term survival to patients. However, long-term therapies might induce several adverse effects, and might affect health-related quality of life (HRQoL). The aim of the study was to assess the HRQoL between ADT users and non-user in PC. Besides, PC patients’ quality of life evaluation was few in Asia. Me

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Post, Hunter. "Left Ventricular Strain and Strain Rate Responses to Submaximal Exercise in Prostate Cancer Patients Treated with Androgen Deprivation Therapy." Thesis, 2018. http://hdl.handle.net/2097/39102.

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Master of Science<br>Department of Kinesiology<br>Carl Ade<br>Background: Androgen Deprivation Therapy (ADT) is a commonly used treatment for prostate cancer with controversy currently surrounding its association with long-term cardiovascular disease risk. Therefore, the aim of the current investigation was to non-invasively measure left ventricular mechanics at rest and during submaximal exercise in human prostate cancer survivors with and without a history of ADT. Methods: Eighteen prostate cancer survivors, 9 with a history of ADT and 9 matched (1:1) non-ADT controls, completed the protoc

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Lam, Teresa. "Androgen deprivation therapy for prostate cancer : novel mechanisms of testosterone action and the benefits of home-based progressive resistance training." Thesis, 2021. http://hdl.handle.net/1959.7/uws:59637.

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Testosterone is a key anabolic hormone which has a major role in the regulation of muscle mass and function, glucose and fat metabolism, mental well-being and general health. Androgen deprivation therapy (ADT) is a common treatment modality in men with prostate cancer. In reducing testosterone to castrate levels, it offers a unique model to study the physiological effects of testosterone. Testosterone is known to act on multiple pathways which regulates muscle mass, fibre hypertrophy and protein turnover. Protein is hydrolysed into amino acids which are then available for synthesis of new pro

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"Drug Modeling Dynamics in the Treatment of Prostate Cancer." Master's thesis, 2020. http://hdl.handle.net/2286/R.I.63019.

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abstract: Efforts to treat prostate cancer have seen an uptick, as the world’s most commoncancer in men continues to have increasing global incidence. Clinically, metastatic prostate cancer is most commonly treated with hormonal therapy. The idea behind hormonal therapy is to reduce androgen production, which prostate cancer cells require for growth. Recently, the exploration of the synergistic effects of the drugs used in hormonal therapy has begun. The aim was to build off of these recent advancements and further refine the synergistic drug model. The advancements I implement come by address

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Wibowo, Erik. "MODULATION OF SEXUAL AND SLEEP FUNCTIONS BY ESTROGEN IN CASTRATED MALE RATS AS A MODEL FOR PROSTATE CANCER PATIENTS ON ANDROGEN DEPRIVATION THERAPY." 2013. http://hdl.handle.net/10222/36281.

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Advanced prostate cancer (PCa) patients are offered androgen deprivation therapy (ADT) to control their cancer’s growth. ADT impairs sexual function and the sleep patterns of ADT patients. Since ADT deprives patients of estrogen, and supplemental estrogen reduces such problems in menopausal women, I studied whether administering estrogen reduces these problems for castrated male rats as a model for PCa patients on ADT. First, I tested how early versus late estradiol treatment after castration influenced rats’ sexual behaviour. Estradiol increases mounting behaviour to comparable levels regardl

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"Comparative effectiveness of primary androgen deprivation therapy versus conservative management and radical prostatectomy among clinically localized prostate cancer patients in SEER-MEDICARE data 1998-2007." Tulane University, 2012.

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Tsai, Yi-Hsun, and 蔡易訓. "The association between androgen-deprivation therapy in prostate cancer and cardiovascular risk, and explore the impact of chronic pulmonary disease in advanced prostate cancer in Taiwan." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/61815476067278155224.

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碩士<br>高雄醫學大學<br>臨床藥學研究所<br>100<br>BACKGROUND: The study aims to analyze the association between androgen deprivation therapy (ADT) and cardiovascular risk and investigate whether chronic pulmonary disease will affect the prognosis of prostate cancer in Taiwan. METHODS: The study can be divied into two parts. The first part is to investigate the association between ADT and cardiovascular risk, and the second part is to investigate the impact of chronic pulmonary disease in prostate cancer. The observational cohort study used data sourced from Longitudinal health Insurance Database (L

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"Applications of the Droop Cell Quota Model to Data Based Cancer Growth and Treatment Models." Doctoral diss., 2015. http://hdl.handle.net/2286/R.I.29732.

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abstract: The phycologist, M. R. Droop, studied vitamin B12 limitation in the flagellate Monochrysis lutheri and concluded that its specific growth rate depended on the concentration of the vitamin within the cell; i.e. the cell quota of the vitamin B12. The Droop model provides a mathematical expression to link growth rate to the intracellular concentration of a limiting nutrient. Although the Droop model has been an important modeling tool in ecology, it has only recently been applied to study cancer biology. Cancer cells live in an ecological setting, interacting and competing with normal a

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