Academic literature on the topic 'Anesthesia Memory Anesthetics Awareness'

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Journal articles on the topic "Anesthesia Memory Anesthetics Awareness"

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Dowd, Noreen P., Davy C. H. Cheng, Jacek M. Karski, David T. Wong, Jo A. Carroll Munro, and Alan N. Sandler. "Intraoperative Awareness in Fast-track Cardiac Anesthesia." Anesthesiology 89, no. 5 (1998): 1068–73. http://dx.doi.org/10.1097/00000542-199811000-00006.

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Background Fast-track cardiac anesthesia, using low-dose narcotics combined with short-acting anesthetic and sedative agents, facilitates early tracheal extubation after cardiac surgery. The incidence of awareness with this anesthetic technique has not been investigated previously. The purpose of this study was to prospectively investigate the incidence of intraoperative awareness with explicit memory of events during fast-track cardiac anesthesia. Methods Data were collected prospectively over a 4-month period from 617 consecutive adult patients undergoing cardiac surgery at a university hospital. All patients received a fast-track cardiac anesthetic regimen. Patients underwent a structured interview by a research nurse 18 h after extubation. A standard set of questions was asked during this interview to determine if the patient had explicit memory of any event from induction of anesthesia to recovery of consciousness. Results Nine patients did not complete a postoperative interview because of death (n = 7) or postoperative confusion (n = 2). The last memory before surgery reported in 420 (69.1%) patients was waiting in the holding area at the operating suite, and in the remaining 188 (30.9%) patients it was lying on the operating table before induction of anesthesia. Two patients (0.3%) had explicit memory of intraoperative events. One of the two patients also had explicit memory of pain. Neither patient reported adverse psychological sequelae. Conclusions The authors report an incidence of awareness in fast-track cardiac anesthesia of 0.3%. This is the lowest incidence of awareness currently reported during cardiac surgery. This low incidence of awareness may be related to the use of a balanced anesthetic technique involving the continuous administration of volatile (isoflurane) or intravenous (propofol) anesthetic agents before, during, and after cardiopulmonary bypass.
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Martin, Loren J., Gabriel H. T. Oh та Beverley A. Orser. "Etomidate Targets α5γ-Aminobutyric Acid Subtype A Receptors to Regulate Synaptic Plasticity and Memory Blockade". Anesthesiology 111, № 5 (2009): 1025–35. http://dx.doi.org/10.1097/aln.0b013e3181bbc961.

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Background The memory-blocking properties of general anesthetics have recently received considerable attention because of concerns related to intraoperative awareness and postoperative cognitive dysfunction. The goal of this study was to identify the mechanisms by which gamma-aminobutyric acid subtype A receptors that contain the alpha5 subunit (alpha5GABAARs) induce memory-blockade by etomidate and a pharmacologic strategy to reverse this impairment. Methods The effects of etomidate and the alpha5GABAAR-preferring inverse agonist L-655,708 on the plasticity of glutamatergic excitatory transmission in hippocampal slices and behavioral memory for spatial navigational and fear-associated memory tasks were studied in wild-type and null mutant mice for the gene that encodes the alpha5 subunit (Gabra5-/- mice). Long-term potentiation of field excitatory postsynaptic potentials was induced in CA1 pyramidal neurons following high-frequency stimulation of Schaffer collaterals. Memory performance was studied in contextual, cued, and trace fear conditioning assays and the Morris water maze. Results Robust synaptic plasticity induced by high-frequency stimulation and memory performance for contextual fear and spatial navigational memory were not influenced by a decrease in the function of alpha5GABAARs. Nevertheless, etomidate, via an increase in alpha5GABAAR activity, completely blocked long-term potentiation and impaired memory performance, and these effects were reversed by pretreatment with L-655,708. Conclusions The results provide the first proof of concept that memory blockade by a general anesthetic can be reversed by inhibiting the function of alpha5GABAARs. The findings suggest a mechanism and model for awareness during anesthesia.
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Sleigh, Jamie W., Kate Leslie, Andrew J. Davidson, et al. "Genetic Analysis of Patients Who Experienced Awareness with Recall while under General Anesthesia." Anesthesiology 131, no. 5 (2019): 974–82. http://dx.doi.org/10.1097/aln.0000000000002877.

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Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Intraoperative awareness with recall while under apparently adequate general anesthesia is a rare, unexplained, and often very distressing phenomenon. It is possible that a relatively small number of genetic variants might underlie the failure of general anesthetic drugs to adequately suppress explicit memory formation and recall in the presence of apparently adequate anesthesia concentrations. Methods The authors recruited 12 adult patients who had experienced an episode of intraoperative awareness with recall (compared with 12 controls), performed whole exome sequencing, and applied filtering to obtain a set of genetic variants that might be associated with intraoperative awareness with recall. The criteria were that the variant (1) had a minor allele frequency less than 0.1% in population databases, (2) was within exonic or splicing regions, (3) caused a nonsynonymous change, (4) was predicted to be functionally damaging, (5) was expressed in the top 50% of genes expressed in the brain, and (6) was within genes in Kyoto Encyclopedia of Genes and Genomes pathways associated with general anesthesia, drug metabolism, arousal, and memory. Results The authors identified 29 rare genetic variants in 27 genes that were absent in controls and could plausibly be associated with this disorder. One variant in CACNA1A was identified in two patients and two different variants were identified in both CACNA1A and CACNA1S. Of interest was the relative overrepresentation of variants in genes encoding calcium channels and purinergic receptors. Conclusions Within the constraints of the filtering process used, the authors did not find any single gene variant or gene that was strongly associated with intraoperative awareness with recall. The authors report 27 candidate genes and associated pathways identified in this pilot project as targets of interest for future larger biologic and epidemiologic studies.
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Hauer, Daniela, Patrizia Ratano, Maria Morena, et al. "Propofol Enhances Memory Formation via an Interaction with the Endocannabinoid System." Anesthesiology 114, no. 6 (2011): 1380–88. http://dx.doi.org/10.1097/aln.0b013e31821c120e.

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Background Propofol is associated with postoperative mood alterations and induces a higher incidence of dreaming compared with other general anesthetics. These effects might be mediated by propofol's inhibitory action on fatty acid amide hydrolase, the enzyme that degrades the endocannabinoid anandamide. Because propofol is also associated with a higher incidence of traumatic memories from perioperative awareness and intensive care unit treatment and the endocannabinoid system is involved in regulating memory consolidation of emotional experiences, the authors investigated whether propofol, at anesthetic doses, modulates memory consolidation via an activation of the endocannabinoid system. Methods Male Sprague-Dawley rats were trained on an inhibitory avoidance task in which they received an inescapable foot shock upon entering the dark compartment of the apparatus. Drugs were administered intraperitoneally immediately or 30, 90, or 180 min after training. On the retention test 48 h later, the latency to reenter the dark compartment was recorded and taken as a measure of memory retention. Results The anesthetic doses of propofol administered after training significantly increased latencies of 48-h inhibitory avoidance performance (483.4 ± 181.3, 432.89 ± 214.06, 300 and 350 mg/kg, respectively; mean ± SD) compared with the corresponding vehicle group (325.33 ± 221.22, mean ± SD), which is indicative of stronger memory consolidation in propofol treated rats. Administration of a nonimpairing dose of the cannabinoid receptor antagonist rimonabant blocked the memory enhancement induced by propofol (123.39 ± 133.10, mean ± SD). Delayed administration of propofol 90 and 180 min after training or immediate posttraining administration of the benzodiazepine midazolam or the barbiturate pentobarbital did not significantly alter retention. Conclusions These findings indicate that propofol, in contrast to other commonly used sedatives, enhances emotional memory consolidation when administered immediately after a stressful event by enhancing endocannabinoid signaling.
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Guerra, Frank. "Memory and Awareness in Anesthesia." Anesthesia & Analgesia 71, no. 5 (1990): 571???572. http://dx.doi.org/10.1213/00000539-199011000-00034.

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EICH, E., I. L. REEVES, and R. L. KATZ. "Anesthesia, Amnesia, and the Memory/Awareness Distinction." Survey of Anesthesiology 30, no. 3 (1986): 128. http://dx.doi.org/10.1097/00132586-198606000-00021.

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Eich, Eric, John L. Reeves, and Ronald L. Katz. "Anesthesia, Amnesia, and the Memory/Awareness Distinction." Anesthesia & Analgesia 64, no. 12 (1985): 1143???1148. http://dx.doi.org/10.1213/00000539-198512000-00002.

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Gaya da Costa, Mariana, Alain F. Kalmar, and Michel M. R. F. Struys. "Inhaled Anesthetics: Environmental Role, Occupational Risk, and Clinical Use." Journal of Clinical Medicine 10, no. 6 (2021): 1306. http://dx.doi.org/10.3390/jcm10061306.

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Inhaled anesthetics have been in clinical use for over 150 years and are still commonly used in daily practice. The initial view of inhaled anesthetics as indispensable for general anesthesia has evolved during the years and, currently, its general use has even been questioned. Beyond the traditional risks inherent to any drug in use, inhaled anesthetics are exceptionally strong greenhouse gases (GHG) and may pose considerable occupational risks. This emphasizes the importance of evaluating and considering its use in clinical practices. Despite the overwhelming scientific evidence of worsening climate changes, control measures are very slowly implemented. Therefore, it is the responsibility of all society sectors, including the health sector to maximally decrease GHG emissions where possible. Within the field of anesthesia, the potential to reduce GHG emissions can be briefly summarized as follows: Stop or avoid the use of nitrous oxide (N2O) and desflurane, consider the use of total intravenous or local-regional anesthesia, invest in the development of new technologies to minimize volatile anesthetics consumption, scavenging systems, and destruction of waste gas. The improved and sustained awareness of the medical community regarding the climate impact of inhaled anesthetics is mandatory to bring change in the current practice.
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Yang, Wei, Mattia Chini, Jastyn A. Pöpplau, et al. "Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation." PLOS Biology 19, no. 4 (2021): e3001146. http://dx.doi.org/10.1371/journal.pbio.3001146.

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General anesthesia is characterized by reversible loss of consciousness accompanied by transient amnesia. Yet, long-term memory impairment is an undesirable side effect. How different types of general anesthetics (GAs) affect the hippocampus, a brain region central to memory formation and consolidation, is poorly understood. Using extracellular recordings, chronic 2-photon imaging, and behavioral analysis, we monitor the effects of isoflurane (Iso), medetomidine/midazolam/fentanyl (MMF), and ketamine/xylazine (Keta/Xyl) on network activity and structural spine dynamics in the hippocampal CA1 area of adult mice. GAs robustly reduced spiking activity, decorrelated cellular ensembles, albeit with distinct activity signatures, and altered spine dynamics. CA1 network activity under all 3 anesthetics was different to natural sleep. Iso anesthesia most closely resembled unperturbed activity during wakefulness and sleep, and network alterations recovered more readily than with Keta/Xyl and MMF. Correspondingly, memory consolidation was impaired after exposure to Keta/Xyl and MMF, but not Iso. Thus, different anesthetics distinctly alter hippocampal network dynamics, synaptic connectivity, and memory consolidation, with implications for GA strategy appraisal in animal research and clinical settings.
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Felipe, Bianca, Sofia Chane, Antonio De Mello, and Gabriela Mayrink. "Knowledge of Dental Students in Relation to Local Anesthetics and Associated Complications." International Journal of Medical and Surgical Sciences 2, no. 2 (2018): 461–67. http://dx.doi.org/10.32457/ijmss.2015.013.

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Local anesthesia is the most frequently performed procedure for all dentists and, despite their possible complications, often aspects such as dosage, contraindications and systemic effects are neglected. The objectives of this study are to evaluate prospectively the knowledge of undergraduate students for the technical, dosage and indication of local anesthetics in daily dental practice, in addition to clinical observation of possible complications from anesthesia. Questionnaires were distributed to students asking about the procedure undertaken, anesthetic volume used, because of the choice of the anesthetic, anesthetic dosage calculation, habit of relating the patient's weight dosage with the dosage being applied, habit of observing the reflux in cartridge in the anesthetic infiltration act and adverse effects on patients, type of anesthetic technique performed and expected time to onset of action of the drug. At the end of this study, we intend to be a greater awareness of students (undergraduates) about the systemic effects of local anesthetics in patients, and possibly decrease the expenses of the institution with excessive use of anesthetic cartridges arising from incorrect anesthetic technique. The vast majority of undergraduate students have no knowledge about the type of anesthesia to be used, the amount to be administered and the anesthetic action time. The awareness of students about the dosage of anesthetics and their systemic problems, reduces waste and the cost of the institution by the indiscriminate use of anesthetics, therebycontributing to improve the clinical management of students at graduation.
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Dissertations / Theses on the topic "Anesthesia Memory Anesthetics Awareness"

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Barr, Gunilla. "Novel neurophysiological monitors of the transition from wakefulness to loss of consciousness during anaesthesia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-597-2/.

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Books on the topic "Anesthesia Memory Anesthetics Awareness"

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Memory during general anaesthesia: Variations in stimulus characteristics. Eburon P&L, 1995.

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Suppressing the mind: Anesthetic modulation of memory and consciousness. Humana, 2010.

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Peter, Sebel, Bonke Benno 1951-, and Winograd Eugene, eds. Memory and awareness in anesthesia. PTR Prentice Hall, 1993.

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1951-, Bonke Benno, Bovill J. G, Moerman N, and International Symposium on Memory and Awareness in Anaesthesia (3rd : 1995 : Rotterdam, Netherlands), eds. Memory and awareness in anaesthesia III. Van Gorcum, 1996.

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Ghoneim, Mohamed M., M.D., ed. Awareness during anesthesia. Butterworth-Heinemann, 2001.

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Bovill, James Gardiner. Memory and Awareness in Anaesthesia III: Proceedings of the Third International Symposium on Memory and Awareness in Anaesthesia, Rotterdam, June 1995. Van Gorcum and Comp BV, 1996.

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Schulz, Christian M. Situation Awareness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199366149.003.0007.

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In anesthesia, situation awareness (SA) represents the degree to which an anesthetist perceives the information in her or his environment, comprehends the patient’s situation, and projects the patient’s situation into the future. There are three levels of SA: perception, comprehension, and projection. After perception, basic information has to be integrated, and several cognitive mechanisms enable correct, complete, and quick development of SA. These processes require long-term memory content such as mental models, similar (prototypical) situations that have been experienced earlier, automaticity, and medical knowledge including guidelines and algorithms. Several tools have the potential to provide qualitative and quantitative assessment of SA in anesthesia, including goal-directed task analysis (GDTA) and SA error taxonomy. In this chapter, the role of SA in anesthesia is illustrated, and factors are described that have the potential for either enhancing or hindering the development of adequate SA.
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1951-, Bonke Benno, Fitch W, Millar Keith 1950-, and International Symposium on Memory and Awareness in Anaesthesia (1st : 1989 : Glasgow, Scotland), eds. Memory and awareness in anaesthesia. Swets & Zeitlinger, 1990.

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Rosen, M. Consciousness, Awareness, and Pain in General Anesthesia. Butterworth-Heinemann, 1987.

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1927-, Rosen M., and Lunn John N, eds. Consciousness, awareness, and pain in general anaesthesia. Butterworths, 1987.

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Book chapters on the topic "Anesthesia Memory Anesthetics Awareness"

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Wang, Michael. "Memory, Awareness and Intravenous Anesthetics." In Total Intravenous Anesthesia and Target Controlled Infusions. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47609-4_43.

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