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Journal articles on the topic 'Anethole'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Moreira-Junior, Luiz, Jose Henrique Leal-Cardoso, Antonio Carlos Cassola, and Joao Luis Carvalho-de-Souza. "State-Dependent Blockade of Dorsal Root Ganglion Voltage-Gated Na+ Channels by Anethole." International Journal of Molecular Sciences 25, no. 2 (2024): 1034. http://dx.doi.org/10.3390/ijms25021034.

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Anethole is a phenolic compound synthesized by many aromatic plants. Anethole is a substance that humans can safely consume and has been studied for years as a biologically active molecule to treat a variety of conditions, including nerve damage, gastritis, inflammation, and nociception. Anethole is thought to carry out its biological activities through direct interaction with ion channels. Anethole is beneficial for neurodegenerative Alzheimer’s and Parkinson’s diseases. Nevertheless, nothing has been investigated regarding the effects of anethole on voltage-gated Na+ channels (VGSCs), which

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2

Vendramin, Veronica, Antonio Pesce, and Simone Vincenzi. "Anethole Stability in Aniseed Spirits: Storage Condition Repercussions on Commercial Products." Beverages 7, no. 4 (2021): 73. http://dx.doi.org/10.3390/beverages7040073.

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Background: trans-anethole is the main component of anise, and its flavor is characteristic of all the aniseed spirits. It is known that trans-anethole oil/ethanol/water solution could result in the undesirable emulsion effect called the “ouzo effect”. Moreover, trans-anethole can undergo chemical decay, producing unhealthy compounds, mainly cis-anethole and para-anisaldehyde. In this work, the trans-anethole stability was challenged simulating commercial products’ long-term storage. Methods: Anethole standard solutions and two Italian aniseed spirits, namely Sambuca and Mistrà, were used to e

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3

Mohamed, Maged Elsayed, Mahmoud Kandeel, Hany M. Abd El-Lateef, Hossam S. El-Beltagi та Nancy S. Younis. "The Protective Effect of Anethole against Renal Ischemia/Reperfusion: The Role of the TLR2,4/MYD88/NFκB Pathway". Antioxidants 11, № 3 (2022): 535. http://dx.doi.org/10.3390/antiox11030535.

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Background: Anethole is the principle essential oil component of anise and fennel. Renal ischemia/reperfusion (RIR) is one of the utmost imperative reasons for acute kidney injury and often associated with high mortality rate. The aim of this study is to investigate the protective effect of anethole on RIR status, exploring the involved mechanisms. Methods: RIR was accomplished by bilateral renal pedicle clamping for 45 min, after which the clamps were removed to achieve the reperfusion phase. Rats were randomized into five groups; Sham, Sham + anethole, RIR, and finally RIR + anethole (125 mg

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4

Handayani, Desi Suci, Alfia Uke Tahara, Maulidan Firdaus, et al. "Synthesis and Characterization of Anethole-lauryl Methacrylate Copolymer via Cationic Polymerization." Molekul 18, no. 3 (2023): 360. http://dx.doi.org/10.20884/1.jm.2023.18.3.7078.

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The synthesis of anethole-lauryl methacrylate (LMA) copolymer had been carried out by cationic polymerization using BF3O(C2H5)2 as the initiator without the use of solvent at room temperature (28-30 °C) over atmospheric N2 conditions. Polymerization was conducted by varying LMA concentration i.e. 2%, 4%, and 6%, (w/w) with respect to the anethole weight. Structural determination of co-poly(anethole-LMA) was done using FTIR and 1H-NMR spectrophotometer. The relative molecular weight (Mv) of co-poly (anethole-LMA) was measured by an Ostwald Viscometer at room temperature. Morphological character

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5

Sittichok, S., Passara, H., Sinthusiri, J., et al. "Plant essential oils, trans-anethole and eugenol, for housefly knockdown and mortality." International Journal of Agricultural Technology 21, no. 2 (2025): 555–62. https://doi.org/10.63369/ijat.2025.21.2.555-562.

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The knockdown and mortality of some compounds from natural oils (trans-anethole, eugenol and a combination of trans-anethole and eugenol) against adult houseflies (Musca domestica) compared with cypermethrin was investigated. The knockdown and mortalities were highest at 100% of 1% trans-anethole with KT50= 31 min and LT50 = 31 min. The mortality index of trans-anethole was 82.1 times that of cypermethrin. In contrast, 1% eugenol had knockdown and mortality was 36% and 0.5% trans-anethole + 0.5% eugenol had knockdown and mortality of 68%, with mortality indexes of 1.6 and 3.2 times versus cype

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6

Hasegawa, Toshio, Haruna Seimiya, Takashi Fujihara, Noriko Fujiwara, and Hideo Yamada. "Aroma Profile of Star Anise and the Structure-odor Relationship of Anethole." Natural Product Communications 9, no. 2 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900230.

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Star anise is an important fragrance material that has a characteristic anise-like odor. Although the main component of star anise is ( E)-anethole, which accounts for over 90% of the constituents, the odor of ( E)-anethole is different from that of the material itself. Here, we examined the aroma profile of star anise. GC-MS analysis of star anise extracts showed that it contains many compounds with structures similar to ( E)-anethole. Our results indicate that ( E)-anethole is the key compound in the odor of star anise, but structurally similar compounds play an important role in creating it

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7

Korff, Marvin, Tiffany O. Paulisch, Frank Glorius, Nikos L. Doltsinis, and Bernhard Wünsch. "Photocatalytic Isomerization of (E)-Anethole to (Z)-Anethole." Molecules 27, no. 16 (2022): 5342. http://dx.doi.org/10.3390/molecules27165342.

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Natural product (E)-anethole was isomerized to (Z)-anethole in a photocatalytic reaction. For this purpose, a self-designed cheap photoreactor was constructed. Among 11 photosensitizers (organo and metal complex compounds), Ir(p-tBu-ppy)3 led to the highest conversion. Triplet energies of (E)- and (Z)-anethole were predicted theoretically by DFT calculations to support the selection of appropriate photosensitizers. A catalyst loading of 0.1 mol% gave up to 90% conversion in gram scale. Further additives were not required and mild irradiation with light of 400 nm overnight was sufficient. As a

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8

Ritter, Alessandra Mileni Versuti, Franciele Queiroz Ames, Fernando Otani, Rubia Maria Weffort de Oliveira, Roberto Kenji Nakamura Cuman, and Ciomar Aparecida Bersani-Amado. "Effects of Anethole in Nociception Experimental Models." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/345829.

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This study investigated the antinociceptive activity of anethole (anethole 1-methoxy-4-benzene (1-propenyl)), major compound of the essential oil of star anise (Illicium verum), in different experimental models of nociception. The animals were pretreated with anethole (62.5, 125, 250, and 500 mg/kg) one hour before the experiments. To eliminate a possible sedative effect of anethole, the open field test was conducted. Anethole (62.5, 125, 250, and 500 mg/kg) showed an antinociceptive effect in the writhing model induced by acetic acid, in the second phase of the formalin test (125 and 250 mg/k

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9

Li, Jiahang, Yingqiu Mao, and Wei Li. "Anethole suppresses the growth of human skin cancer cells by targeting microRNA498/STAT4 axis." Tropical Journal of Pharmaceutical Research 21, no. 11 (2023): 2391–96. http://dx.doi.org/10.4314/tjpr.v21i11.18.

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Purpose: To investigate the effects of anethole on human skin cancer cells. Methods: Cell viability was determined using CCK-8 and colony formation assay, while AO/EB and Annexin V/PI assays were used to assess apoptosis. The mRNA expressions of genes were assayed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Results: The growth of skin cancer cells was significantly reduced by anethole (p < 0.05). On the other hand, normal human skin cells were marginally affected by anethole. Furthermore, anethole significantly suppressed the colony formation poten

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10

Kumar, Venkata, and Maddula Venkateswarulu. "Anethole attenuates lung cancer progression by regulating the proliferation and apoptosis through AKT and STAT3 signaling." STEMedicine 4, no. 1 (2023): e153. http://dx.doi.org/10.37175/stemedicine.v4i1.153.

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Background: The main constituent of fennel, anethole, exerts beneficial effects in many diseases, including antiproliferative and tumoricidal capacities. This study aimed to investigate the effect of anethole on the human non-small cell lung cancer (NSCLC) cell line, A549, and the related molecular mechanisms. Methods: The proliferation was assessed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and colony formation assays. Apoptosis situation was determined using fluorescence-activated cell sorting and DNA fragmentation assay combined with immunoblotting assay probing-r

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Kumar, Venkata, and Maddula Venkateswarulu. "Anethole attenuates lung cancer progression by regulating the proliferation and apoptosis through AKT and STAT3 signaling." STEMedicine 4, no. 1 (2023): e153. http://dx.doi.org/10.37175/stemedicine.v4.i1.153.

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Background: The main constituent of fennel, anethole, exerts beneficial effects in many diseases, including antiproliferative and tumoricidal capacities. This study aimed to investigate the effect of anethole on the human non-small cell lung cancer (NSCLC) cell line, A549, and the related molecular mechanisms. Methods: The proliferation was assessed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and colony formation assays. Apoptosis situation was determined using fluorescence-activated cell sorting and DNA fragmentation assay combined with immunoblotting assay probing-r

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12

Pinheiro-Lustosa, Romário, Neide Maria Silva Gondim-Pereira, Sarah Aparecida dos Santos Alves, et al. "Effects of Anethole on Renal Function of Swiss Mice." Pharmaceuticals 18, no. 4 (2025): 541. https://doi.org/10.3390/ph18040541.

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Background/Objectives: Anethole, a terpenoid with several pharmacologic effects, is the major constituent of the essential oil of Croton zehntneri (EOCz), Pax & K. Hoffm, Euphorbiaceae. Due to the mild renal toxicity associated with high doses of EOCz, its potential therapeutic effects on several diseases, and the fact that its chemical composition consists of 80% anethole, the renal effects of anethole in mice were investigated. Methods: Mice were randomly divided into eight groups, dosed daily as follows: Group 1—CTRL (control; vehicle only); Groups 2—A100, 3—A1252x, and 4—A250 (dosed wi

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13

Chang, Wonseok, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, and Sun Seek Min. "Trans-Anethole Alleviates Trimethyltin Chloride-Induced Impairments in Long-Term Potentiation." Pharmaceutics 14, no. 7 (2022): 1422. http://dx.doi.org/10.3390/pharmaceutics14071422.

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Trans-anethole is an aromatic compound that has been studied for its anti-inflammation, anticonvulsant, antinociceptive, and anticancer effects. A recent report found that trans-anethole exerted neuroprotective effects on the brain via multiple pathways. Since noxious stimuli may both induce neuronal cell injury and affect synaptic functions (e.g., synaptic transmission or plasticity), it is important to understand whether the neuroprotective effect of trans-anethole extends to synaptic plasticity. Here, the effects of trimethyltin (TMT), which is a neurotoxic organotin compound, was investiga

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14

Sousa, Marcimar Silva, Bruna Farias Brito, Marco Aurélio Schiavo Novaes, et al. "Effect of adding anethole to the cryopreservation medium (powdered coconut water) on morphology, kinetics, and oxidative stress of buck sperm." Semina: Ciências Agrárias 42, no. 6 (2021): 3235–46. http://dx.doi.org/10.5433/1679-0359.2021v42n6p3235.

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The quality of post-thawing goat sperm is critical to the success of artificial insemination protocols and may be influenced by extenders, cryoprotectants, and antioxidant substances. Therefore, the objective of this study was to evaluate the effects of the antioxidant anethole on goat sperm diluted in preservation medium based on powdered coconut water (ACP-101c) and frozen. For that, each ejaculate was submitted to the following treatments: ACP-101c (control); control plus supplementation with 30, 300, or 2000 μg/mL anethole. The samples were thawed and evaluated for morphology, kinetics, me

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15

Elkady, Ayman I. "Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis." Anti-Cancer Agents in Medicinal Chemistry 18, no. 2 (2018): 216–36. http://dx.doi.org/10.2174/1871520617666170725165717.

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Background: Prostate cancer-associated mortality is increasing at an alarming rate, which highlights the inevitability for unearthing novel agent for the management of this disease. Anethole, a major constituent of Foeniculum vulgare (fennel) essential oil, is widely used in folk medicine; it possesses anti-oxidant, antiinflammatory, anti-proliferative and tumoricidal potentialities. Objective: The current research was conducted to assess the impact of anethole on prostate cancer cell line, PC- 3, and to delineate the molecular mechanism of action. Methods: To achieve this aim, the growth-inhi

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16

Sabahi, Qodratollah, Mollah Md Hamiduzzaman, Juan S. Barajas-Pérez, Jose M. Tapia-Gonzalez, and Ernesto Guzman-Novoa. "Toxicity of Anethole and the Essential Oils of Lemongrass and Sweet Marigold to the Parasitic Mite Varroa destructor and Their Selectivity for Honey Bee (Apis mellifera) Workers and Larvae." Psyche: A Journal of Entomology 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/6196289.

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This study examined the toxicity of anethole and that of the essential oils of lemongrass (Cymbopogon citratus) and sweet marigold (Tagetes lucida) to the mite Varroa destructor and to honey bee workers and larvae. Anethole was the most toxic compound to V. destructor (LC50: 304.9 μg/ml), whereas Tagetes oil was the least toxic (LC50: 1256.27 μg/ml). The most and least toxic compounds to worker bees were anethole and Tagetes oil with LD50s of 35942 and 85381 μg/ml, respectively. For larvae, Tagetes oil was the most toxic compound (LD50: 9580.7 μg/ml) and anethole the least toxic (LD50: 14518.0

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17

Yuepeng Cao, Qin Zhong, Fang Tang, Xueming Yao, Zhengqi Liu, and Xiaodong Zhang. "Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRs/MyD88 pathway." Allergologia et Immunopathologia 50, no. 6 (2022): 107–14. http://dx.doi.org/10.15586/aei.v50i6.682.

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Objective: To assess the effects of anethole on monosodium urate (MSU)-induced inflammatory response, investigate its role in acute gouty arthritis (AGA), and verify its molecular mechanism. Methods: Hematoxylin and eosin staining assay and time-dependent detection of degree of ankle swelling were performed to assess the effects of anethole on joint injury in MSU-induced AGA mice. Enzyme-linked-immunosorbent serologic assay was performed to demonstrate the production levels of inflammatory factors (interleukin 1β [IL-1β], interleukin 6 [IL-6], interleukin 8 [IL-8], tumor necrosis factor α [TNF

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18

Semlali, Abdelhabib, Ikram Ajala, Sarra Beji, Mohammed Mousa Al-Zharani та Mahmoud Rouabhia. "Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways". Pharmaceuticals 16, № 5 (2023): 700. http://dx.doi.org/10.3390/ph16050700.

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Cisplatin is a common drug used to treat patients with oral squamous cell carcinoma. However, cisplatin-induced chemoresistance poses a major challenge to its clinical application. Our recent study has shown that anethole possesses an anti-oral cancer effect. In this study, we examined the combined effect of anethole and cisplatin on oral cancer therapy. Gingival cancer cells Ca9-22 were cultured in the presence of various concentrations of cisplatin with or without anethole. The cell viability/proliferation and cytotoxicity were evaluated, respectively, by MTT, Hoechst staining, and LDH assay

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19

Kwiatkowski, Paweł, Bartosz Wojciuk, Iwona Wojciechowska-Koszko, et al. "Innate Immune Response against Staphylococcus aureus Preincubated with Subinhibitory Concentration of trans-Anethole." International Journal of Molecular Sciences 21, no. 11 (2020): 4178. http://dx.doi.org/10.3390/ijms21114178.

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The study aimed to analyze morphological and functional changes of Staphylococcus aureus cells due to trans-anethole (a terpenoid and the major constituent of fennel, anise, or star anise essential oils) exposition, and their consequences for human neutrophils phagocytic activity as well as IL-8 production (recognized as the major chemoattractant). The investigation included the evaluation of changes occurring in S. aureus cultures, i.e., staphyloxanthin production, antioxidant activities, cell size distribution, and cells composition as a result of incubation with trans-anethole. It was found

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Asadian, Maryam, Hashem Yaghoubi, Fariba Mahmoudi, and Khadijeh Haghighat Gollo. "Effect of Trans-Anethole on Gene Expression of Steroidogenic Enzymes in the Ovary of Polycystic Ovary Syndrome Model Rate." Galen Medical Journal 11 (December 13, 2022): e2219. http://dx.doi.org/10.31661/gmj.v11i.2219.

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Background: The process of steroidogenesis is crucial to the normal function of the ovaries. In individuals with polycystic ovary syndrome (PCOS), the activity of related enzymes in this process is disrupted. In the present study, the effect of trans-anethole was investigated on gene expression of steroidogenesis enzymes in PCOS model rats. Materials and Methods: In this experimental study, thirty female rats were divided into six groups (n=5 per group). Fifteen PCOS rats in three groups received intraperitoneal injections of distilled water, 50, and 80 mg/kg of trans-anethole, respectively. A

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DUȚĂ, Denisa Eglantina, Alina CULEȚU, Mioara NEGOIȚĂ, and Valentin Ionescu. "Quantification of Anethole in Fennel and Anise Essential Oils using Gas Chromatography and 1H-NMR-Spectroscopy." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Food Science and Technology 76, no. 2 (2019): 105. http://dx.doi.org/10.15835/buasvmcn-fst:2019.0020.

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Nine essential oils from fennel (seeds and herbs) and anise (seeds) from different origins were analysed for density, refractive index and for a complete composition through GC-MS and 1H-NMR-spectroscopy. Anethole was the main compound identified in fennel and anise essential oils. Anethole content varied between 30 – 90% in fennel oils and between 80 – 99% in anise oils; anethole is often used as flavouring substance in foods with a good antimicrobial activity also. A positive correlation was found between anethole content determined by GC-MS and 1H-NMR (r = 0.8567 for fennel oils and r = 0.6

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22

Aboelhadid, Shawky M., Waleed M. Arafa, Abdel-Azeem S. Abdel-Baki, et al. "Acaricidal activity of Foeniculum vulgare against Rhipicephalus annulatus is mainly dependent on its constituent from trans-anethone." PLOS ONE 16, no. 12 (2021): e0260172. http://dx.doi.org/10.1371/journal.pone.0260172.

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Globally, the economic losses due to hard ticks infestation and the control of the associated diseases have been calculated at USD $13.9–18.7 billion per year. The economic impact is related to its direct damage to the skins, blood loss, anemia, severe immunological reactions and indirect losses that related to the effects of hemoparasites, cost of treatment for clinical cases and expenses incurred in the control of ticks. The current study evaluated the acaricidal activities of fennel Foeniculum vulgare essential oil and its main components; trans-anethole and fenchone; against R. annulatus.

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Kochan, Ewa, Piotr Szymczyk, Łukasz Kuźma, et al. "The Increase of Triterpene Saponin Production Induced by Trans-Anethole in Hairy Root Cultures of Panax quinquefolium." Molecules 23, no. 10 (2018): 2674. http://dx.doi.org/10.3390/molecules23102674.

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In vitro cultivation is an effective way to increase pharmaceutical production. To increase ginsenoside production in hairy root cultures of American ginseng, the present study uses trans-anethole as an elicitor. The content of nine triterpene saponins was determined: Rb1, Rb2, Rb3, Rc, Rd, Rg1, Rg2, Re and Rf. Trans-anethole was found to stimulate saponin synthesis regardless of exposure time (24 and 72 h). Twenty-four hour exposure to 1 μmol trans-anethole in the culture medium resulted in the highest increase of total saponin content (twice that of untreated roots), and optimum accumulation

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Bonetti, Carla Indianara, Jackeline Joyce da Silva Moreira, Edvalkia Magna Teobaldo da Rocha, et al. "Trans-anethole, the major constituent of the essential oil of anise, improves the antiarthritic effects of methotrexate in rats." Research, Society and Development 11, no. 10 (2022): e197111032582. http://dx.doi.org/10.33448/rsd-v11i10.32582.

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The aim of this study was to evaluate the effect of trans-anethole in combination with methotrexate, compared to monotherapy with trans-anethole or methotrexate, on inflammatory parameters and oxidative stress of arthritic rats. The experimental model of arthritis induced by Freund's complete adjuvant (AIA) in rats was used. Treatment with trans-anethole and methotrexate, in combination or monotherapy, was started on the day of AIA induction and continued for 21 days. The association of anethole (62.5 mg/Kg) to methotrexate (6 mg/Kg) therapy was able to further reduce both the oxidative stress

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Dindar, Mahsa, Seyed Mahdi Banan Khojasteh, Hatam Ahmadi, Homiera Hatami Nemati та Fariba Mahmoudi. "Investigating the effect of trans-anethole on the expression changes of TNF-α, resistin, and chemerin genes in visceral adipose tissue caused by estradiol valerate injection in female wistar rats". Medical Journal of Tabriz University of Medical Sciences 47, № 1 (2025): 41–51. https://doi.org/10.34172/mj.025.33564.

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Background. Polycystic ovary syndrome (PCOS) is one of the endocrine diseases of the reproductive system, with a prevalence of 5‒10% in women, and one of its symptoms is an increase in the serum amount of pro-inflammatory adipokines from adipose tissue. Methods. This study was performed on six groups of 6 female rats, including a sham group, an estradiol valerate experimental group that received a concentration of 2 mg per kg of estradiol valerate, and two trans-anethole experimental groups that received concentrations of 50 mg/kg and 80 mg/kg of trans-anethole. The other groups were two exper

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Najdoska, Menče, Jane Bogdanov, and Zoran Zdravkovski. "TLC and GC-MS Analyses of Essential Oil Isolated from Macedonian Foeniculi fructus." Macedonian Pharmaceutical Bulletin 56 (2011): 29–36. http://dx.doi.org/10.33320/maced.pharm.bull.2010.56.004.

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The essential oil of Foeniculi fructus, the ripe fruit from the plant Foeniculum vulgare Mill. ssp. vulgare var. dulce Batt. and Trab. (sweet fennel, македонски анасон) was isolated and the main components were identified and quantified using thin-layer chromatography (TLC) and gas chromatography and mass spectrometry (GC-MS). The Aetherloeum Foeniculi had pale yellow color and characteristic pleasant odor and was obtained in 3.2% yield (by weight from the plant fruits). The main components of the oil were: trans-anethole, 1, (70%), p-anisaldehyde, 2, (19%) estragole, 3, (6%) and anisacetone,

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Barbosa-Ferreira, Bianca de Sousa, Francisca Edilziane Rodrigues da Silva, Yuri de Abreu Gomes-Vasconcelos, et al. "Anethole Prevents the Alterations Produced by Diabetes Mellitus in the Sciatic Nerve of Rats." International Journal of Molecular Sciences 25, no. 15 (2024): 8133. http://dx.doi.org/10.3390/ijms25158133.

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Anethole is a terpenoid with antioxidant, anti-inflammatory, and neuronal blockade effects, and the present work was undertaken to study the neuroprotective activity of anethole against diabetes mellitus (DM)-induced neuropathy. Streptozotocin-induced DM rats were used to investigate the effects of anethole treatment on morphological, electrophysiological, and biochemical alterations of the sciatic nerve (SN). Anethole partially prevented the mechanical hyposensitivity caused by DM and fully prevented the DM-induced decrease in the cross-sectional area of the SN. In relation to electrophysiolo

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Iftitah, Elvina Dhiaul, Warsito Warsito, Vivi Nurhadianty, Fitri Ariadna Sodi Miranda, and Rafika Nur Hafidah. "Extraction of <i>trans</i>-Anethole from Star Anise (<i>Illicium verum</i>) Using Combination of Microwave, Ultrasonic, and Enzyme Assisted Methods and Evaluation of Their Antibacterial Activity." Indonesian Journal of Chemistry 24, no. 2 (2024): 325. http://dx.doi.org/10.22146/ijc.79341.

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This study examines the efficiency of non-conventional extraction methods to obtain trans-anethole from Illicium verum using single and combination extraction techniques: microwave assisted extraction (MAE), ultrasound-assisted extraction (UAE), and enzyme assisted extraction (EAE) employing lipase from Aspergillus oryzae. All extraction methods were conducted using 96% ethanol (1:5 w/v) with varying time durations. The resulting product was an oleoresin, subsequently analyzed and separated using thin liquid chromatography (TLC) and column chromatography employing a solvent mixture of toluene

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Reyes-Camacho, David, José F. Pérez, Ester Vinyeta, Tobias Aumiller, Jan D. Van der Klis, and David Solà-Oriol. "Prenatal Exposure to Innately Preferred D-Limonene and Trans-Anethole Does Not Overcome Innate Aversion to Eucalyptol, Affecting Growth Performance of Weanling Piglets." Animals 11, no. 7 (2021): 2062. http://dx.doi.org/10.3390/ani11072062.

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In the present research, two studies were performed to determine the effects of specific botanical compounds (BCs) on the innate feed preference and feed intake of piglets, as follows: Exp. 1 studied the innate feed preferences of post-weaning piglets using a double-choice feeding test. A total of 828 weaned piglets were distributed into 36 pens (23 pigs/pen) and assigned to three dietary pair choice feeding options (n = 12): unsupplemented prestarter diets (reference) versus reference plus D-limonene, trans-anethole, or eucalyptol. Piglets showed a preference for diets with D-limonene (53.8%)

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Anjos, J. C., F. L. N. Aguiar, N. A. R. Sá, et al. "Anethole improves blastocysts rates together with antioxidant capacity when added during bovine embryo culture rather than in the in vitro maturation medium." Zygote 27, no. 6 (2019): 382–85. http://dx.doi.org/10.1017/s0967199419000443.

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SummaryWe performed the exposure of bovine oocytes to anethole during in vitro maturation (0 or 300 µg/ml), during in vitro embryo production (0, 30, 300 or 2000 µg/ml), or during both periods to determine the rates of 2−4 cells embryos, blastocysts rates and cells numbers, as well as the production of reactive oxygen species (ROS). Bovine ovaries (n = 240) were collected from a local abattoir after slaughter and cumulus–oocyte complexes (COCs) with homogeneous and non-dark cytoplasm, surrounded by two or more compact layers of cumulus cells, and an intact zona pellucida were selected for in v

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KUSUMANINGSIH, TRIANA, DESI SUCI HANDAYANI, and ANDI MAKRUF. "Synthesis of perfume compound etil p-anisat from anethole." Biofarmasi Journal of Natural Product Biochemistry 2, no. 2 (2004): 58–63. http://dx.doi.org/10.13057/biofar/f020203.

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Synthesis of ethyl p-anisate from anethole has been done. Ethyl p-anisate is ester compound which can use as perfume component. p-anisic acid was synthesized from anethole (1 mole) which oxidised by KMnO4 (3 moles) at 40oC for 2 hours. Esterification with ethanol carried out at 78,5oC for 6 hours. Identification and determination structure compound of product synthesis used spectroscopic methods (GC, GC-MS and IR). Anethole has been isolated from anise oil as 90,3%. p-Anisic acid and ethyl p-anisate as synthesized products got 45% and 79,9% respectively.

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Lena, Jean-Baptiste, Alexander M. van Herk, and Satyasankar Jana. "Effect of anethole on the copolymerization of vinyl monomers." Polymer Chemistry 11, no. 35 (2020): 5630–41. http://dx.doi.org/10.1039/d0py00833h.

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Copolymerization behavior of Anethole with common vinyl monomers, determination of reactivity ratios via nonlinear least square method and the effect of Anethole on molecular weight and branching of copolymers produced via batch and semi-batch processes were reported.

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Hammache, Meriem, Sara Benchekroun, Abdullah Alamri, et al. "Modulation of signature cancer-related genes in oral cancer cells (Ca9-22) by anethole treatment: Insights into therapeutic potential." PLOS ONE 19, no. 12 (2024): e0315085. https://doi.org/10.1371/journal.pone.0315085.

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To explore an alternative strategy to chemotherapy to combat oral cancer, natural products and their derivates constitute one promising approach. In the last previous study, we have demonstrated the potential anti-tumor properties of anethole; an aromatic compound abundantly present in nature that serves as a major active ingredient found in plants like anise and fennel. In the current study, we aimed to investigate how this molecule inhibits oral cancer cell proliferation and induces apoptosis. This will be carried out by a transcriptomic study of its effects on the expression profile of cell

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Ghasemi-Dehnoo, Maryam, Amir Abbas Safari, Mohammad Rahimi-Madiseh, Zahra Lorigooini, Mohammad Taghi Moradi, and Hossein Amini-Khoei. "Anethole Ameliorates Acetic Acid-Induced Colitis in Mice: Anti-Inflammatory and Antioxidant Effects." Evidence-Based Complementary and Alternative Medicine 2022 (April 6, 2022): 1–7. http://dx.doi.org/10.1155/2022/9057451.

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Anethole has possessed anti-inflammatory and antioxidant responses in numerous studies. Oxidative stress has a pivotal role in the pathophysiology of colitis. The current study is designed to determine the effect of anethole on acetic acid-induced colitis in mice in view of its possible anti-inflammatory and antioxidant properties. In this study, 48 mice were grouped into 6 groups (n = 8), and colitis was induced with 0.2 ml of 7% acetic acid. Mice received intraperitoneally (i.p.) for 7 constant days normal saline and/or anethole at doses of 31.25, 62.5, 125, and 250 mg/kg, respectively. Afte

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Khan, M. Masroor A., Zake M. Azam, and Samiullah Samiullah. "Changes in the essential oil constituents of fennel (Foeniculum vulgare) as influenced by soil and foliar levels of N and P." Canadian Journal of Plant Science 79, no. 4 (1999): 587–91. http://dx.doi.org/10.4141/p98-090.

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In a split-plotfield trial, the effect of foliar (F) application of 0 or 20 kg N, 2 kg P or 20 kg N + 2 kg P ha−1.was studied on the composition (analysed by GLC) and yield of fennel essential oil constituents grown with two soil (S) levels (60 kg N + 27 kg P and 90 kg N + 0 kg P ha−1). Camphene and dfenchone, both being bicyclic monoterpenes, and d-α-pinene, another bicyclic monoterpene showed a similar trend (R = 0.87) and their contents were maximum with FN20P2 at both soil levels. Methylchavicol and anethole (Phenylpropanoids) exhibited parallel trends (R = 0.56), with the control giving h

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Kirgiafini, Dimitra, Argyris Serafim, Urania Menkissoglu-Spiroudi, Trifone D’Addabbo, Nikolaos Tsiropoulos, and Nikoletta Ntalli. "Nematicidal trans-Anethole Blends Paralyzing Meloidogyne incognita." Agriculture 14, no. 6 (2024): 889. http://dx.doi.org/10.3390/agriculture14060889.

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Nematodes have a negative impact on crop production and yield. The use of synthetic formulations to control plant parasitic nematodes carries both environmental and human health risks. As these agrochemicals are gradually being phased out, recent research has been focused on finding more environmentally friendly, plant-based alternatives. This study aims to investigate the effectiveness of botanicals, used alone or in artificial blends, in paralyzing Meloidogyne incognita second-stage juveniles (J2s) immersed in test solutions or exposed to vapors. We tested thymol, trans-anethole, and two lav

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Raman, S., M. Asle-Rousta, and M. Rahnema. "Protective effect of fennel, and its major component trans-anethole against social isolation induced behavioral deficits in rats." Physiology International 107, no. 1 (2020): 30–39. http://dx.doi.org/10.1556/2060.2020.00012.

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AbstractSocial isolation damages the nervous system by weakening the antioxidant system and leading to behavioral disorders. Fennel (Foeniculum vulgare Mill.) is an herbal plant that has antioxidant and neuroprotective properties. The objective of this study was to evaluate the effect of fennel methanol extract and its major component trans-anethole on spatial learning and memory, anxiety and depression in male rats exposed to social isolation stress.Rats were divided into six groups of Control (C), Fennel (F), trans-Anethole (A), Isolation, Isolation-F and Isolation-A. The rats were kept in t

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Moradi Vastegani, Sadegh, Seyed Esmaeil Khoshnam, Samireh Ghafouri, Nima Bakhtiari, Yaghoob Farbood та Alireza Sarkaki. "Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson’s disease of male rats". PLOS ONE 18, № 11 (2023): e0294612. http://dx.doi.org/10.1371/journal.pone.0294612.

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Introduction Anethole is the main compound of the essential oil of anise and several other plants, which has antioxidant, anti-inflammatory, and neuroprotective properties. Oxidative stress is considered as an important factor in the pathogenesis of PD. In the present study, we aimed to investigate the effects of anethole against rotenone-induced PD. Methods Male Wistar rats were randomly divided into six groups. Control group received DMSO + sunflower oil, model group received rotenone (2 mg/kg, s.c, daily for 35 days), positive control group received L-Dopa, and test groups received anethole

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Šunić, Ljubomir, Zoran S. Ilić, Ljiljana Stanojević, et al. "Comparison of the Essential Oil Content, Constituents and Antioxidant Activity from Different Plant Parts during Development Stages of Wild Fennel (Foeniculum vulgare Mill.)." Horticulturae 9, no. 3 (2023): 364. http://dx.doi.org/10.3390/horticulturae9030364.

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The study was conducted to determine fennel essential oil (FEO) yield, composition, and antioxidant activity during four different maturation stages of umbels with seeds (1st stage: immature-pasty; 2nd stage: premature-waxy; 3rd stage: mature-fully ripe; and 4th stage: seeds only), and leaves of wild fennel (Foeniculum vulgare Mill. subsp. vulgare) from the Montenegro coast. The maximum oil yield was found in premature umbels at the waxy stage (4.76 mL/100 g p.m.) and in fully ripe umbels in the early fruiting stage (5.16 mL/100 g p.m.). Fully ripe seeds contained the lowest FEO (mL/100 g p.m.

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Ueda, Yuki, Yuhei O. Tahara, Makoto Miyata, et al. "Involvement of a Multidrug Efflux Pump and Alterations in Cell Surface Structure in the Synergistic Antifungal Activity of Nagilactone E and Anethole against Budding Yeast Saccharomyces cerevisiae." Antibiotics 10, no. 5 (2021): 537. http://dx.doi.org/10.3390/antibiotics10050537.

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Nagilactone E, an antifungal agent derived from the root bark of Podocarpus nagi, inhibits 1,3-β glucan synthesis; however, its inhibitory activity is weak. Anethole, the principal component of anise oil, enhances the antifungal activity of nagilactone E. We aimed to determine the combinatorial effect and underlying mechanisms of action of nagilactone E and anethole against the budding yeast Saccharomyces cerevisiae. Analyses using gene-deficient strains showed that the multidrug efflux pump PDR5 is associated with nagilactone E resistance; its transcription was gradually restricted in cells t

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Seo, Jeong Won, Sarmin Ummey Habiba, Yeasmin Akter Munni, et al. "Protective Effects of Anethole in Foeniculum vulgare Mill. Seed Ethanol Extract on Hypoxia/Reoxygenation Injury in H9C2 Heart Myoblast Cells." Antioxidants 13, no. 10 (2024): 1161. http://dx.doi.org/10.3390/antiox13101161.

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Background: Active compounds from plants and herbs are increasingly incorporated into modern medical systems to address cardiovascular diseases (CVDs). Foeniculum vulgare Mill., commonly known as fennel, is an aromatic medicinal plant and culinary herb that is popular worldwide. Methods: Protective effects against cellular damage were assessed in the H9C2 cardiomyocyte hypoxia/reoxygenation (H/R) experimental model. The identities of phytochemicals in FVSE were determined by GC-MS analysis. The phytochemical’s potential for nutrients and pharmacokinetic properties was assessed by ADMET analysi

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Pencheva, Martina, Maria Nikolova, Stanka Damianova, Mariya Dushkova, Nikolay Menkov, and Albena Stoyanova. "Inhibitory Effect of Fennel Fruit Essential Oil and Its Main Component Anethole of Corrosion on Steel Plates in 1 M HCL." Applied Sciences 14, no. 16 (2024): 7240. http://dx.doi.org/10.3390/app14167240.

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Corrosion worldwide causes large losses of metal, which is why various ways are being sought to slow it down. The aim of this study was to investigate the inhibitory effect of fennel fruit essential oil (Foeniculum vulgare Mill.) and its main component anethole. The inhibitory effect of three different concentrations of the fennel essential oil and anethole (1.0 mL/L, 1.5 mL/L, and 2.5 mL/L) in a solution of 1 M HCl at 298 K for 6 h on a sheet of low-carbon steel was investigated. The inhibitory effect was established using gravimetric methods evaluating weight loss, corrosion rate, and inhibi

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Dias, Marcelle L., Alexander M. Auad, Milena C. Magno, Tiago T. Resende, Marcy G. Fonseca, and Sandra E. B. Silva. "Insecticidal Activity of Compounds of Plant Origin on Mahanarva spectabilis (Hemiptera: Cercopidae)." Insects 10, no. 10 (2019): 360. http://dx.doi.org/10.3390/insects10100360.

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The damage caused by spittlebugs varies according to the species of grass, and the losses can reach alarming levels. Measures for population control are currently restricted to the use of resistant grasses and the diversification of pastures. Therefore, alternative control measures are necessary, such as the use of botanical insecticides. The aim of this study was to evaluate the insecticidal activities of thymol, carvacrol, eugenol, cinnamaldehyde, and trans-anethole on Mahanarva spectabilis eggs, nymphs, and adults under laboratory conditions. In the egg tests, treatments with eugenol, carva

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Kostić, Igor, Slobodan Milanović, Miroslav Kostić, et al. "Antifeeding, Toxic, and Growth-Reducing Activity of trans-Anethole and S-(+)-Carvone against Larvae of the Gypsy Moth Lymantria dispar (L.)." Agronomy 12, no. 12 (2022): 3049. http://dx.doi.org/10.3390/agronomy12123049.

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Botanicals, such as essential oils (EO) and their compounds, are considered a viable eco-friendly alternative to synthetic insecticides, which threaten human health and ecosystem functioning. In the present study, we explored the potential use of two EO compounds, trans-anethole (phenylpropanoide) and S-(+)-carvone (monoterpene ketone), against gypsy moth larvae (GML), a serious pest of deciduous forests and orchards. GML feeding, survival, molting, and nutritional physiology were assessed at different compound concentrations and compared with the effects of the commercial botanical product Ne

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ÖZEL, ABDULHABIP. "ANISE (PIMPINELLA ANISUM): CHANGES IN YIELDS AND COMPONENT COMPOSITION ON HARVESTING AT DIFFERENT STAGES OF PLANT MATURITY." Experimental Agriculture 45, no. 1 (2009): 117–26. http://dx.doi.org/10.1017/s0014479708006959.

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SUMMARYThis study investigated the effects of harvesting at different plant maturation stages on the yield and component compositions of aniseed. It was carried out on the Harran Plain (Sanliurfa, Turkey) in the 2002 and 2003 growing seasons. A randomized complete block design was used. The plants were harvested at 10 different growth stages and determinations were made of the yields of seed, the essential oil and its main component (E)-anethole, the weight of 1000 seeds, the number of umbels per plant, the number of seedless umbels per plant and number of seeds per umbel. Statistical analyses

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Dawidar, A. Mahmoud, M. Mahmoud Abou-Elzahab, M. Abdel-Mogib, Kh Hussien, and M. El-Hoseiny Mostafa. "Photo-Oxygenation of Trans Anethole." International Journal of Science and Engineering Applications 4, no. 5 (2015): 294–98. http://dx.doi.org/10.7753/ijsea0405.1012.

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SHIGEMOTO, Tadashi, and Kazuhiko ITOH. "Synthesis of anethole from propylphenol." NIPPON KAGAKU KAISHI, no. 6 (1990): 702–4. http://dx.doi.org/10.1246/nikkashi.1990.702.

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Wisniewski, Edirlene Sara, Bruno Ambrósio da Rocha, Eduardo Alexandre Loth, et al. "Effect of anethole and anethole+itraconazole assiciantion on experimental arthritis induced by Paracoccidioides brasiliensis." Research, Society and Development 13, no. 3 (2024): e11013345343. http://dx.doi.org/10.33448/rsd-v13i3.45343.

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In this study, the effect of treatment with anethole (AN) and the combination anethole+itraconazole (AN+IT) compared to IT, on infectious arthritis induced by Paracoccidiodes brasiliensis, was evaluated. The animals were treated for 14 days at doses of anethole (AN - 62.5, 125 and 250 mg/kg), itraconazole (IT - 12.5, 25 and 50 mg/kg) and the combination of anethole+itraconazole (AN+ IT - 62.5 and 12.5 mg/kg). The parameters evaluated were: the development of knee edema, the number of leukocytes recruited into the joint cavity, the body weight of the animals, the walking capacity, the plasmatic

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Van, Dinh Thuy, Pham The Chinh, Pham Thi Tham, Mai Thanh Nga, and Thongsaving Ounkuea. "Chemical components as a potential resource for synthesis of organic compounds and anti-inflammatory activity of essential bark oil of Illicium verum." Research Journal of Chemistry and Environment 28, no. 1 (2023): 68–72. http://dx.doi.org/10.25303/281rjce68072.

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In this work, the essential bark oil (EBO) of Illicium verum cultivated at Cao Bang in Vietnam obtained by hydro-distillation was investigated for its chemical composition by gas chromatography-mass spectrometry (GC-MS). Trans-anethole (78.6%), estragole (13.7%), linalool (2.1%) and eucalyptol (2.0%) were determined to be the main components among 14 identified compounds, which accounted for 96.4% of the total EBO. Anti-inflammatory activity of EBO was evaluated by inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. EBO exhibited an interesting in

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Santos, Hélcio S., Gilvandete M. P. Santiago, João P. P. de Oliveira, Angela M. C. Arriaga, Délcio D. Marques, and Telma L. G. Lemos. "Chemical Composition and Larvicidal Activity against Aedes Aegypti of Essential Oils from Croton Zehntneri." Natural Product Communications 2, no. 12 (2007): 1934578X0700201. http://dx.doi.org/10.1177/1934578x0700201208.

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The chemical composition of the essential oils from leaves, stalks and inflorescences of Croton zehntneri obtained by hydrodistillation were analyzed by GC-MS and CG-FID. E-Anethole was the main component of the essential oils of all plant parts. Essential oils of leaves, stalks, inflorescences and E-anethole were tested at different concentrations against instar III larvae of Aedes aegypti and showed LC50 values of 56.2 ± 0.3, 51.3 ± 0.3, 57.5 ± 0.1 and 69.2 ± 0.5 μg/mL, respectively.

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