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Dissertations / Theses on the topic 'Angiogenic cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

A, Ahern Megan, Black Claudine P, Seedorf Gregory J, Baker Christopher D, and Shepherd Douglas P. "Hyperoxia impairs pro-angiogenic RNA production in preterm endothelial colony-forming cells." AMER INST MATHEMATICAL SCIENCES-AIMS, 2017. http://hdl.handle.net/10150/626103.

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Disruptions in the response of endothelial progenitor cells to changes in oxygen environment may present a possible mechanism behind multiple pediatric pulmonary disease models, such as bronchopulmonary dysplasia. Using high-throughput fixed single-cell protein and RNA imaging, we have created "stop-motion" movies of Thymosin. 4 (T beta 4) and Hypoxia Inducible Factor 1 alpha (HIF-1 alpha) protein expression and vascular endothelial growth factor (vegf) and endothelial nitric oxide synthase (eNOS) mRNA in human umbilical cord-derived endothelial colony-forming cells (ECFC). ECFC were grown in

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2

Foroni, Laura <1978&gt. "Resident angiogenic mesenchymal stem cells from multiorgan donor thoracic aortas." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/976/.

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Stem cells are one of the most fascinating areas of biology today, and since the discover of an adult population, i.e., adult Stem Cells (aSCs), they have generated much interest especially for their application potential as a source for cell based regenerative medicine and tissue engineering. aSCs have been found in different tissues including bone marrow, skin, intestine, central nervous system, where they reside in a special microenviroment termed “niche” which regulate the homeostasis and repair of adult tissues. The arterial wall of the blood vessels is much more plastic than ever before

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3

Milewski, Michael Edward. "The Angiogenic effect of Erythropoietin on Stem Cells In-Vitro." Master's thesis, Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/127595.

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Biology<br>M.S.<br>Angiogenesis is a normal and vital process that occurs during growth and development. Repair of bony defects, whether in the craniofacial complex or the alveolus, require an alloplastic or xenoplastic bone graft with angiogenic potential. This angiogenic potential is derived from existing blood vessels adjacent to the graft site. Improving the endogenous angiogenic potential with a molecule would drastically improve the survival rate of the bone graft material. This study was conducted to test the hypothesis that specific stem cell lines treated with erythropoietin, a positi

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4

Latham, Nicholas. "Second Generation Cardiac Cell Therapy: Combining Cardiac Stem Cells and Circulating Angiogenic Cells for the Treatment of Ischemic Heart Disease." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24293.

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Blood-derived circulatory angiogenic cells (CACs) and resident cardiac stem cells (CSCs) have both been shown to improve cardiac function after myocardial infarction (MI) but the superiority of either cell type has long been an area of speculation with no definitive head-to-head trial. In this study, we compared the paracrine profile of human CACs and CSCs, alone or in combination. We characterized the therapeutic ability of these cells to salvage myocardial function in an immunodeficient mouse model of MI by transplanting these cells as both single and dual cell therapies seven days after e

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Giordano, Céline. "Pre-Clinical Evaluation of Biopolymer Delivered Circulating Angiogenic Cells in Hibernating Myocardium." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20619.

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Vasculogenic cell-based therapy combined with tissue engineering is a promising revascularization strategy for patients with hibernating myocardium, a common clinical condition. We used a clinically relevant swine model of hibernating myocardium to examine the benefits of biopolymer-supported delivery of circulating angiogenic cells (CACs) in this context. Twenty-five swine underwent placement of an ameroid constrictor on the left circumflex artery (LCx). After 2 weeks, positron emission tomography measures of myocardial blood flow (MBF) and myocardial flow reserve (MFR) were reduced in the af

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6

Ward, K. L. "Analysing the angiogenic potential of mesothelial cells in vitro and in vivo." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3008101/.

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7

Webster, Katie Elizabeth. "Angiogenesis in endometriosis : the role of circulating angiogenic cells and the endometrium." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:33c8921c-8320-4559-8298-52d85c8a2987.

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Endometriosis is a common cause of subfertility and pelvic pain, affecting up to 10% of women of reproductive age. It is characterised by the presence of endometrial-like tissue outside the uterus. The development of the disease is still poorly understood and, currently, the diagnosis relies on visualisation of typical lesions during surgery. There is great interest in identifying biomarkers to assist in diagnosis and disease management. Blood vessel development is known to be a crucial feature of endometriosis, but the mechanisms involved in angiogenesis are not well described for this diseas

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8

Zhuge, Xin. "CXCL16 is a novel angiogenic factor for human umbilical vein endothelial cells." Kyoto University, 2005. http://hdl.handle.net/2433/144481.

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9

Russell, Hugh. "Early angiogenic change in dental pulp stromal cells cultured on biomimetic matrices." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/13395/.

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Revascularisation of the devitalised root canal is the Holy Grail of Endodontics and is being hotly pursued by many teams of clinicians but has yet to be achieved. The overall aim of this work was to attempt to induce early angiogenesis in human dental pulp stromal cells (DPSCS) in vitro and in vivo using a biomimetic approach based on combining scaffolds comprised of ECM components with DPSCs as a first step towards a tissue engineering strategy for dental pulp regeneration. After isolating DPSCs using collagenase digest, they were cultured on 1% hyaluronic acid (HyA) or Types I and III colla

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10

Ostojic, Aleksandra. "Use of a Collagen I Matrix to Enhance the Potential of Circulating Angiogenic Cells (CACs) for Therapy." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/31931.

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Acute myocardial infarction (MI) is the end result of many cardiovascular diseases and is one of the leading causes of death in the western world. Cell therapy, using circulating angiogenic cells (CACs) or CD34+ cells from peripheral blood, is one approach under investigation for restoring blood flow and function to the ischemic heart. However, the numbers of CACs and CD34+ circulating cells are inversely proportional to the severity of cardiovascular disease and age; therefore, there is a need to increase their numbers and/or function for therapy. One possibility is to enhance the therapeutic

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11

Ye, Qinmao. "Exosomes Released from Multiple Myeloma Cells Influence the Angiogenic Function of Endothelial Cells by Regulating MicroRNA-29b." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1532474227694747.

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12

Angara, Kartik Prasad. "CXCR2 Expressing Tumor Cells Drive Vascular Mimicry in Anti-angiogenic Therapy Resistant Glioblastoma." Thesis, Augusta University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10839522.

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<p> Glioblastoma (GBM) is a hypervascular and hypoxic neoplasia of the central nervous system with an extremely high rate of mortality. Owing to its hypervascularity, anti-angiogenic therapies (AAT) have been used as an adjuvant to the traditional surgical resection, chemotherapy, and radiation to normalize blood vessels, control abnormal vasculatures and prevent recurrence. The benefits of AAT have been transient and the tumors were shown to relapse faster and demonstrated particularly high rates of AAT-induced therapy resistance due to activation of alternative neovascularization mechanisms.

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13

Farjood, Farhad. "Effect of Physical Stimuli on Angiogenic Factor Expression in Retinal Pigment Epithelial Cells." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7457.

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Age-related macular degeneration (AMD) is a major cause of blindness in adults. Abnormal growth of blood vessels in the eye during the course of AMD causes damage to the retina, resulting in irreversible blindness. The goal of this research was to determine whether physical pressure on retinal cells can contribute to the increased blood vessel formation. To replicate the tears in the cell layers, a micropatterning method was used as a means of detaching cells from each other. Two new devices were also developed to mimic slow and fast increases in mechanical pressure on cell layers of the eye.

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Lewis, Deana L. "Angiogenic Characteristics of Tumor-Associated Dendritic Cells in Ovarian and Breast Cancer Models." Ohio University Art and Sciences Honors Theses / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1462296303.

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15

Ramakrishnan, Devi Prasadh. "Mechanisms of Anti-Angiogenic Signaling by CD36." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1417004434.

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16

Pasupuleti, Vinay. "A novel peptide derived from the functional domain of AGGF1 has anti-angiogenic activity." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1310957711.

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Andriu, Alexandra. "Evaluating the utility of αvβ3 integrin antagonists to detect and treat angiogenic tumour cells". Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=240026.

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Tumour angiogenesis, the formation of new blood vessels within a tumour, is a hallmark of cancers, that allows them to grow beyond a critical size and to metastasize to other organs. As the key driver of tumour angiogenesis, αvβ3 integrin is both an established therapeutic target for anti-angiogenic drugs and a biomarker for imaging agents. Accurate detection of αvβ3 integrin in angiogenic tumours impacts patient prognosis and could report on therapy response. Over the last twenty years, novel αvβ3 integrin-targeted radiotracers have been developed for PET imaging of tumour angiogenesis. While

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18

Pranjol, Md Zahidul Islam. "Regulation of angiogenic processes in omental endothelial cells during metastasis of epithelial ovarian cancer." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/29914.

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Epithelial ovarian cancer frequently metastasizes to the omentum, a process that requires pro-angiogenic activation of local microvascular endothelial cells (ECs) by tumour-secreted factors. We have previously shown that ovarian cancer cells secrete factors, other than vascular endothelial growth factor (VEGF), with possible roles in metastatic angiogenesis including the lysosomal proteases cathepsin L (CathL) and cathepsin D (CathD), and insulin-like growth factor binding protein 7 (IGFBP7). However, the mechanisms by which these factors may contribute to omental endothelial angiogenic change

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19

Ross, Mark D. "The influence of age, cardiorespiratory fitness, exercise and sedentary behaviours on circulating angiogenic cells and cell surface receptor expression." Thesis, Edinburgh Napier University, 2016. http://researchrepository.napier.ac.uk/Output/10295.

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Cardiovascular disease (CVD) is the biggest killer of people in western civilisation. Age is a significant risk factor for the development for CVD, and treatments and therapies to address this increased risk are crucial to quality of life and longevity. Exercise is one such intervention which has been shown to reduce CVD risk. Age is also associated with endothelial dysfunction, reduced angiogenic capabilities, and reduced ability to repair the vessel wall. Circulating angiogenic cells (CACs) are a subset of circulating cells which assist in the repair and growth of the vasculature and in the

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20

Hein, Melanie [Verfasser], and Manfred [Gutachter] Gessler. "Functional analysis of angiogenic factors in tumor cells and endothelia / Melanie Hein. Gutachter: Manfred Gessler." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1112040110/34.

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21

Yahyouche, Asma. "Evaluation of channels for angiogenic cells ingrowth in collagen scaffolds in vitro and in vivo." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:55835c59-0ef7-40ec-b5dd-f6ae901f1151.

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Pre-cellularised scaffolds are limited in volume due to the constraints of the time delay required for angiogenic cells ingrowth forming a vascular network and allowing for delivery of nutrients and waste exchange. Channels have the potential to improve the time taken for cellular penetration. The effectiveness of channels in improving angiogenic cells penetration was assessed in vitro and in vivo in porous 3-D collagen scaffolds. Initial studies conducted in vitro demonstrated that the scaffolds supported angiogenic cells ingrowth in culture and the channels improved the depth of penetration

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22

McGuire, David Robert. "Silencing Endothelial EphA4 Alters Transcriptional Regulation of Angiogenic Factors to Promote Vessel Recovery Following TBI." Thesis, Virginia Tech, 2020. http://hdl.handle.net/10919/99318.

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Traumatic brain injury (TBI) can cause a number of deleterious effects to the neurovascular system, including reduced cerebral blood flow (CBF), vascular regression, and ischemia, resulting in cognitive decline. Research into therapeutic targets to restore neurovascular function following injury has identified endothelial EphA4 receptor tyrosine kinase as a major regulator of vascular regrowth. The research outlined herein utilizes an endothelial-specific EphA4 knockout mouse model (KO-EphA4flf/Tie2-Cre) to determine the extent to which this receptor may influence vascular regrowth following T

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23

McEwan, Kimberly A. "Synthesis and Characterization of Tissue-engineered Collagen Hydrogels for the Delivery of Therapeutic Cells." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23935.

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The expanding field of tissue engineering provides a new approach to regenerative medicine for common ailments such as cardiovascular disease and type-I diabetes. Biomaterials can be administered as a delivery vehicle to introduce therapeutic cells to sites of damaged or diseased tissue. A specific class of biomaterials, termed hydrogels, is suitable for this application as they can provide a biocompatible, biodegradable scaffold that mimics the physical properties of the native soft tissue. Injectable hydrogels are increasingly being developed for biomedical applications due to their abili

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24

Zhang, Hua-Tang. "Transfection of angiogenic factors into human MCF-7 breast carcinoma cells : effects on growth in vivo." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308606.

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25

Sofrenovic, Tanja. "Evaluation of an Enhanced (Sialyl Lewis-X) Collagen Matrix for Neovascularization and Myogenesis in a Mouse Model of Myocardial Infarction." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22747.

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In cardiovascular disease the repair response is insufficient to restore blood flow, leading to the death of muscle and loss of tissue function. Therefore, strategies to augment the endogenous cell response and its effects may help improve tissue recovery and function. In this study we explored the use of tissue-engineered collagen matrices for augmenting endogenous regenerative processes after myocardial infarction. Treatment with the sLeX-collagen matrix reduced inflammation and apoptosis and had a positive regenerative effect on the infarcted mouse heart, through improved vascular density a

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26

Balaji, Swathi. "In situ tissue engineering using angiogenic peptide nanofibers to enhance diabetic wound healing." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291151135.

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27

Andrikopoulos, Petros. "The effect of ionic fluxes on cell signalling and the angiogenic properties of human umbilical vein vascular endothlial cells ( HUVECs) in vitro." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520939.

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28

Möller, Björn. "Human endometrial angiogenesis : an immunohistochemical study of the endometrial expression of angiogenic growth factors and their corresponding receptors /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3900.

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29

Deshane, Jessy S. "Regulation of HO-1 and its role in angiogenesis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/deshane.pdf.

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30

Lam, In Kei. "Anti-angiogenic activities of flavonoids from Pericarpium Citri Reticulatae on human umbilical vein endothelial cells (HUVECs) and zebrafish." Thesis, University of Macau, 2010. http://umaclib3.umac.mo/record=b2447360.

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31

Gourlaouen, Morgane. "Receptor internalisation in endothelial cells is required for signalling and angiogenesis in response to pro-angiogenic growth factors." Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545930.

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32

Chambers, Sarah Elizabeth Jane. "Analysis of the vasoreparative and anti-inflammatory potential of circulating angiogenic cells (CACS) for the treatment of diabetic retinopathy." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695297.

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Interest in regenerative medicine is increasing, in particular, the use of cell-based therapies for treatment of ischaemic diseases has renewed hope of finding a cure, beyond the treatment of symptoms. CAC-based cytotherapy significantly enhances vascular repair in the murine ischaemic retina and is mediated by paracrine release of angiogenic factors. This pro-angiogenic potential of CACs could be harnessed as a novel cellular therapy for the treatment of DR. However, CACs are dysfunctional in diabetes and raises concerns that exposure to the diabetic milieu alters CACs to a phenotype that cou

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33

Amirrasouli, Muhammad Mehdi. "Characterisation of cardiosphere derived cells : investigating hypoxic pre-conditioning on pro-angiogenic properties and tracking the cardiac fibroblast component." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2570.

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Coronary heart disease is still the leading cause of death in the UK, despite significant advances in clinical treatments. Stem cell transplantation has the potential to improve cardiac function and patient outcome, but optimal cell types, cell preparation methods and cell delivery routes are yet to be established. The heart contains a small population of progenitor cells that, in culture, contribute to spontaneously formed spheroids known as cardiospheres (Csphs). Following further culture, Csphs give rise to cardiosphere derived cells (CDCs). Both Csphs and CDCs show paracrine benefit includ

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34

Khalil, Alia. "Apolipoprotein L3 and Myeloperoxidase interfere with the angiogenic process via regulation of MAPK and Akt pathways." Doctoral thesis, Universite Libre de Bruxelles, 2017. https://dipot.ulb.ac.be/dspace/bitstream/2013/260994/4/thesis.pdf.

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Endothelial dysfunction is a broad term which implies alteration of the overall functions of endothelial cells, including impairment of the barrier functions, vasodilation, and disturbances in proliferative and angiogenic capacities, migratory as well as tube formation, and deterrence of leukocyte transmigration. Such a dysfunction is triggered by pro-inflammatory stimuli and has been associated to several pathological conditions including atherosclerosis. Myeloperoxidase is a heme peroxidase secreted by activated neutrophils at site of inflammation near blood vessels and plays an important ro

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35

Tang, Yubo. "Traditional Chinese Medicine extracts exert angiogenic and protective effects towards human endothelial progenitor cells: from cellular function to molecular pathway." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-144400.

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Despite intense research efforts, the repair of large bone defects is still not satisfactory and remains a major challenge in Orthopaedic Surgery. In this context bone tissue engineering has emerged as a promising strategy. However, one of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. Thus an active blood vessel network is an essential pre-requisite for scaffold constructs to integrate within existing host tissue. Currently, great efforts are made to address this problem employing

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Kolar, Mallappa K. "The use of adipose derived stem cells in spinal cord and peripheral nerve repair." Licentiate thesis, Umeå universitet, Anatomi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-89445.

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Clinically, injuries affecting the spinal cord or peripheral nerves can leave those affected with severe disability and, at present, there are limited options for treatment. Peripheral nerve injury with a significant gap between the proximal and distal stumps is currently treated with autologous nerve grafting but this is limited by availability of donor nerve and has associated morbidities. In contrast, injuries to the spinal cord lead to an inhibitory environment caused by the glial cells and thereby, limit potential axonal regeneration. This thesis investigates the effects of human adipose

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Chen, Lin Min. "Angiogenic activities of Drynaria fortunei-derived extract and isolated compounds on zebrafish in vivo and human umbilical vein endothelial cells in vitro." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690926.

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Pons, Maria J., Cláudia Gomes, Ruth Aguilar, et al. "Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru." Public Library of Science, 2017. http://hdl.handle.net/10757/622210.

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Analysis of immune responses in Bartonella bacilliformis carriers are needed to understand acquisition of immunity to Carrion’s disease and may allow identifying biomarkers associated with bacterial infection and disease phases. Serum samples from 144 healthy subjects from 5 villages in the North of Peru collected in 2014 were analyzed. Four villages had a Carrion’s disease outbreak in 2013, and the other is a traditionally endemic area. Thirty cytokines, chemokines and growth factors were determined in sera by fluorescent bead-based quantitative suspension array technology, and analyzed in re

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Möller, Björn. "Human Endometrial Angiogenesis : An Immunohistochemical Study of the Endometrial Expression of Angiogenic Growth Factors and Their Corresponding Receptors." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3900.

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<p>The human endometrium undergoes dramatic changes in morphology and function during the menstrual cycle. Recurrent angiogenesis (the formation of new blood vessels) is of utmost importance for oxygen supply and nourishment of the rapidly growing endometrial tissue. </p><p>The importance of some growth factors known to stimulate new blood vessel formation both in vivo and in vitro in non-uterine tissues, for endometrial angiogenesis, was studied. Further, the possible relationship between the patterns of expression of some angiogenic growth factors and bleeding disturbances during the use of

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Haidar, Mariam [Verfasser], and Frauke von [Akademischer Betreuer] Versen-Höynck. "Vitamin D improves the angiogenic properties of endothelial progenitor cells / Mariam Haidar. Klinik für Frauenheilkunde und Geburtshilfe der Medizinischen Hochschule Hannover. Betreuer: Frauke von Versen-Höynck." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2014. http://d-nb.info/106067632X/34.

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Descamps, Betty. "Etude des propriétés angiogéniques du système Wnt/Frizzled : implication du récepteur Frizzled 4 dans la morphogénèse artérielle." Thesis, Bordeaux 2, 2009. http://www.theses.fr/2009BOR21670/document.

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De plus en plus d’études impliquent la signalisation Wnt/Frizzled (Wnt/Fzd) dans la formation des vaisseaux. La première partie de ce manuscrit démontre d’ailleurs que la signalisation Wnt, via son régulateur sFRP1 et un de ses ligands, Wnt4, potentialise les effets angiogéniques des cellules souches mésenchymateuses lors de l’angiogénèse. Le récepteur Frizzled4 (Fzd4), lui, est impliqué dans le développement vasculaire de la rétine puisque la délétion du gène fzd4 révèle une malformation du réseau vasculaire rétinien secondaire et tertiaire. Le but de ce travail a été d’étudier l’implication

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O'Rourke, Fiona [Verfasser], Ingo [Akademischer Betreuer] Ebersberger, Eckhard [Akademischer Betreuer] Boles, Volker [Akademischer Betreuer] Müller, and Volkhard A. J. [Akademischer Betreuer] Kempf. "Interactions of Bartonella henselae with myeloid angiogenic cells and consequences for pathological angiogenesis / Fiona O'Rourke. Betreuer: Ingo Ebersberger ; Eckhard Boles. Gutachter: Volker Müller ; Volkhard A. J. Kempf." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2015. http://d-nb.info/1080033920/34.

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Al-Delfi, Ibtesam. "The potential application of canine and human mesenchymal stem cells for the treatment of spinal cord injury : an in vitro examination of their neurotrophic and angiogenic activities." Thesis, Aston University, 2017. http://publications.aston.ac.uk/33385/.

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Traumatic spinal cord injury (SCI) is a devastating event. It causes severe damage to the nervous tissue which can be associated with partial or complete loss of movement and sensation. Recent studies suggested that the benefits of stem cell transplants for SCI may not be restricted to cell restoration alone, e.g. to replace damaged neurons, but also may be due to their capacity to stimulate endogenous cells at wound sites through paracrine activity. Mesenchymal stem/stromal cells (MSCs), in particular, are thought to have anti-inflammatory, neuroprotective, neurotrophic and angiogenic effects

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Vilsmaier, Theresa [Verfasser], and Udo [Akademischer Betreuer] Jeschke. "Influence of circulating tumour cells on the immune response of T-Lymphocytes and Angiogenic cytokines in sera of patients with the primary diagnosis of breast cancer before treatment / Theresa Vilsmaier ; Betreuer: Udo Jeschke." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1192215427/34.

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Tang, Yubo [Verfasser], Maik Akademischer Betreuer] Stiehler, Angela [Akademischer Betreuer] Jacobi, Michael [Akademischer Betreuer] [Gelinsky, and Klaus-Peter [Akademischer Betreuer] Günther. "Traditional Chinese Medicine extracts exert angiogenic and protective effects towards human endothelial progenitor cells: from cellular function to molecular pathway / Yubo Tang. Gutachter: Michael Gelinsky ; Klaus-Peter Günther. Betreuer: Maik Stiehler ; Angela Jacobi." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://d-nb.info/1068447044/34.

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Ding, Haixia. "Effet de la radiothérapie sur la libération de microvésicules tumorales par des cellules de glioblastome." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0197.

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Dans le glioblastome (GBM), la radiothérapie est un outil thérapeutique essentiel. Néanmoins, la récidive post-irradiation est quasiment inévitable, en raison de l’émergence d'une sous-population de cellules cancéreuses particulièrement radiorésistantes présentant une meilleure capacité proliférative, invasive et pro-angiogénique. Notre étude in vitro a cherché à déterminer comment les cellules cancéreuses survivantes à l’irradiation pouvaient affecter la fonction des cellules tumorales voisines et les cellules endothéliales non irradiées, en focalisant notre attention sur l’échange des signau

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Agra, Isabela Karine Rodrigues. "Expressão de células natural killer e suas citocinas em gestações gemelares complicadas com pré-eclâmpsia." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12062018-130315/.

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OBJETIVOS: Comparar a expressão placentária de células natural killer deciduais (dNK), e a expressão sérica e placentária de suas citocinas reguladoras em gestações gemelares com pré-eclâmpsia (grupo pré-eclâmpsia, GPE) e sem comorbidades (grupo-controle, GC). MÉTODOS: Estudo transversal do tipo caso-controle, desenvolvido na Clínica Obstétrica do HC-FMUSP no período de julho de 2015 a junho de 2017. Foram obtidas amostras das regiões deciduais placentárias, para avaliação, por meio de técnica de imuno-histoquímica, da expressão de células dNK e suas interleucinas (IL) 10, 12 e 15, em paciente

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Farrar, Charlotte Elizabeth. "Molecular regulation of angiogenesis by protese-activated receptors (PARS): differential utilisaton of cyclooxygenase-2 and peroxisome proliferator-activated receptor." Thesis, Royal Veterinary College (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618320.

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Pimentel, Thaís Valéria Costa de Andrade. "Influência de fatores de crescimento pró-angiogênicos na manutenção das características de células progenitoras mesenquimais derivadas do tecido adiposo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17153/tde-02022016-100332/.

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A manutenção do estado progenitor durante o cultivo de células mesenquimais progenitoras derivadas do tecido adiposo (MSCs-TA), caracterizado pelo potencial de diferenciação e da capacidade de autorrenovação, é atualmente um dos maiores desafios da terapia celular. Sabendo da influência da angiogênese no desenvolvimento de tecidos de origem mesenquimal, avaliamos se um ambiente pro-angiogênico mimetizado em cultura forneceria condições para manutenção de um estado progenitor durante o processo de expansão celular. Utilizando como modelo de um ambiente pró-angiogênico o cultivo no meio EGM-2, o

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Taylor-Marchetti, Melissa. "Cellules endothéliales circulantes et progéniteurs endothéliaux circulants : biomarqueurs de l'angiogénèse tumorale et des traitements anti-angiogéniques et anti-vasculaires." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00794880.

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Malgré l'efficacité thérapeutique avérée des agents anti-angiogéniques et des agents anti-vasculaires (VDA), le mécanisme d'action précis des stratégies ciblant les vaisseaux sanguins tumoraux, les raisons de leur efficacité ainsi que les mécanismes de résistance à ces drogues sont encore mal compris. Il est rapidement apparu essentiel d'identifier des biomarqueurs capables de refléter l'angiogénèse tumorale ou les effets sur la vascularisation tumorale de ces traitements. Compte tenu de leur importance dans des pathologies vasculaires, les cellules endothéliales matures circulantes (CEC) et l

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