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Journal articles on the topic 'Angiotensin-1 converting enzyme'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Shaha, Kunal Bikram, Ashok Adhikari, Jung Rae Cho, Bimal Pandey, Yubaraj Sharma, and Sajjad Safi. "Angiotensin-Converting Enzyme Inhibitor / Angiotensin II Receptor Blocker in COVID-19: a Double-edged Sword or a Myth." Nepalese Medical Journal 3, no. 1 (2020): 309–12. http://dx.doi.org/10.3126/nmj.v3i1.28726.

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Angiotensin-converting enzyme-2 receptor has been unearthed as a prime site of entry of Severe Acute Respiratory Syndrome Coronavirus 2 owing to its strong affinity towards spike protein of Severe Acute Respiratory Syndrome Coronavirus 2, resulting in down-regulation of Angiotensin-converting enzyme -2 receptors and hyperstimulation of Angiotensin-converting enzyme-1 pathway. This proposed theory has led to the birth of a new controversy regarding the use of Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers in Coronavirus disease 2019 patients. A theory is against the use

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2

Ferrario, Carlos M. "Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7)." Hypertension 47, no. 3 (2006): 515–21. http://dx.doi.org/10.1161/01.hyp.0000196268.08909.fb.

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3

Chadwick, I. G., M. Kraskiewicz, W. W. Yeo, K. S. Higgins, P. R. Jackson, and L. E. Ramsay. "No Relation between Angiotensin-Converting Enzyme Gene Polymorphism and Dermal Responses to Bradykinin in Healthy Subjects." Clinical Science 91, no. 5 (1996): 617–20. http://dx.doi.org/10.1042/cs0910617.

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1. The dermal wheal response to bradykinin is increased by drugs which inhibit angiotensin-converting enzyme, and thus provides a measure of angiotensin-converting enzyme activity at the tissue level. An insertion/deletion polymorphism of the angiotensin-converting enzyme gene predicts serum angiotensin-converting enzyme activity, but its relation to angiotensin-converting enzyme activity in tissue is unclear. 2. The relations between angiotensin-converting enzyme genotype and wheal responses to intradermal bradykinin were studied in 105 healthy subjects: 30 of genotype DD, 51 of genotype ID a

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4

Ferrario, Carlos M., and Jasmina Varagic. "The ANG-(1–7)/ACE2/mas axis in the regulation of nephron function." American Journal of Physiology-Renal Physiology 298, no. 6 (2010): F1297—F1305. http://dx.doi.org/10.1152/ajprenal.00110.2010.

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The study of experimental hypertension and the development of drugs with selective inhibitory effects on the enzymes and receptors constituting the components of the circulating and tissue renin-angiotensin systems have led to newer concepts of how this system participates in both physiology and pathology. Over the last decade, a renewed emphasis on understanding the role of angiotensin-(1–7) and angiotensin-converting enzyme 2 in the regulation of blood pressure and renal function has shed new light on the complexity of the mechanisms by which these components of the renin angiotensin system

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5

Li, Ruyin, Tongtong Tang, Feifei Ma, et al. "Identification of Three Novel Angiotensin-I-Converting Enzyme Inhibitory Peptides from Cassia Obtusifolia Seeds and Evaluation of their Inhibition Mechanisms." Current Topics in Nutraceutical Research 22, no. 1 (2023): 108–15. http://dx.doi.org/10.37290/ctnr2641-452x.22:108-115.

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Angiotensin-I-converting enzyme inhibitory peptides were isolated from Cassia obtusifolia seeds by alcalase hydrolysis. Using ultrafiltration, the peptides were divided into four fractions (<1, 1–3, 3–5, >5 kDa). The fraction below 1 kDa exhibited the appropriate ACE inhibition (IC50 = 65.88 μg/mL), and was further purified by gel filtration chromatography, which displayed better angiotensin-I-converting enzyme inhibitory activity (IC50 = 53.67 μg/mL). The amino acid sequences of three novel angiotensin-I-converting enzyme inhibitory peptides were identified by liquid chromatography with

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6

Stevens, B. R., A. Fernandez, and C. del Rio Martinez. "Angiotensin converting enzyme in brush-border membranes of avian small intestine." Journal of Experimental Biology 135, no. 1 (1988): 1–8. http://dx.doi.org/10.1242/jeb.135.1.1.

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Angiotensin converting enzyme activity was identified in brush-border membranes purified from the small intestinal epithelium of the common grackle, Quiscalus quiscula. Angiotensin converting enzyme was enriched 20-fold in the membrane preparation, compared with intestinal epithelial cell scrapes, and was coenriched with the brush-border markers, alkaline phosphatase and aminopeptidase N. The kinetics of hydrolysis of N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine (FAPGG) gave a Vmax of 907 +/− 41 units g-1 and a Km of 55 +/− 6 mumol l-1. The avian intestinal angiotensin converting enzyme

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7

Chappell, Mark C., Nancy T. Pirro, Angela Sykes, and Carlos M. Ferrario. "Metabolism of Angiotensin-(1–7) by Angiotensin-Converting Enzyme." Hypertension 31, no. 1 (1998): 362–67. http://dx.doi.org/10.1161/01.hyp.31.1.362.

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8

Praddaude, Françoise, Tuan Tran-Van, Jeannine Marchetti, Jean-Pierre Girolami, and Jean-Louis Ader. "Effects of Chronic Administration of an Angiotensin-Converting Enzyme Inhibitor on Angiotensin-Converting Enzyme Activity in the Pars Recta of Rabbits." Clinical Science 79, no. 1 (1990): 29–35. http://dx.doi.org/10.1042/cs0790029.

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1. To determine whether chronic angiotensin-converting enzyme inhibition induces a decrease in proximal tubular angiotensin-converting enzyme activity, urine and blood samples were collected in conscious New Zealand rabbits before and after 16 days administration in drinking water of low doses of captopril (2.6 ± 0.6 mg 24 h−1 kg−1), high doses of captopril (7.6 ± 0.9 mg 24 h−1 kg−1) or no captopril (controls). The kidneys were then removed and angiotensin-converting enzyme activity was determined in isolated pars recta of microdissected nephrons as pmol of tritiated hippurylglycylglycine subs

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9

Moniwa, Norihito, Jasmina Varagic, Stephen W. Simington, et al. "Primacy of angiotensin converting enzyme in angiotensin-(1–12) metabolism." American Journal of Physiology-Heart and Circulatory Physiology 305, no. 5 (2013): H644—H650. http://dx.doi.org/10.1152/ajpheart.00210.2013.

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Angiotensin-(1–12) [ANG-(1–12)], a new member of the renin-angiotensin system, is recognized as a renin independent precursor for ANG II. However, the processing of ANG-(1–12) in the circulation in vivo is not fully established. We examined the effect of angiotensin converting enzyme (ACE) and chymase inhibition on angiotensin peptides formation during an intravenous infusion of ANG-(1–12) in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). WKY and SHR were assigned to a short ANG-(1–12) infusion lasting 5, 15, 30, or 60 min ( n = 4–10 each group). In another exp

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10

Butler, R., A. D. Morris, and A. D. Struthers. "Angiotensin-Converting Enzyme Gene Polymorphism and Cardiovascular Disease." Clinical Science 93, no. 5 (1997): 391–400. http://dx.doi.org/10.1042/cs0930391.

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1. The crucial role played by the renin-angiotensin—aldosterone system in the cardiovascular system and the immense therapeutic potential of angiotensin-converting enzyme inhibitors and, more recently, angiotensin II receptor blocking agents, in both heart failure and post-myocardial infarction is becoming increasingly evident. Polymorphisms within the genes controlling this enzyme system are candidates for the elucidation of the pathogenesis of cardiovascular disease and this link is both intriguing and provocative. Recently, an association between a polymorphism of the angiotensin-converting

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11

Duggan, K. A., G. Hodge, M. M. Makarious, and J. A. Charlesworth. "Renoprotective Differences between Perindopril and Enalapril in the Diabetic Hypertensive Rat Do Not Reflect Glomerular Angiotensin-Converting Enzyme Activity." Clinical Science 94, no. 5 (1998): 511–16. http://dx.doi.org/10.1042/cs0940511.

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1. The various angiotensin-converting enzyme inhibitors have structural differences which affect their affinities for the catalytic sites on converting enzyme. We postulated that such differences might result in differences in renoprotective efficacy. We investigated this in the diabetic spontaneous hypertensive rat. We also investigated whether these differences might reflect variations in glomerular or plasma angiotensin-converting enzyme activity. 2. One week after induction of diabetes, rats were started on antihypertensive therapy: enalapril, 10 mg · day−1 · kg−1, or perindopril, 4 mg · d

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12

Danser, A. H. Jan, Murray Epstein, and Daniel Batlle. "Renin-Angiotensin System Blockers and the COVID-19 Pandemic." Hypertension 75, no. 6 (2020): 1382–85. http://dx.doi.org/10.1161/hypertensionaha.120.15082.

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During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19. This includes patients with hypertension, heart disease, diabetes mellitus, and clearly the elderly. Many of those patients are treated with renin-angiotensin system blockers. Because the ACE2 (angiotensin-converting enzyme 2) protein is the receptor that facilitates coronavirus entry into cells, the notion has been popularized that treatment with renin-angiotensin system blockers might incre

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13

Zietse, Robert, Frans H. Derkx, Willem Weimar, and Maarten A. Schalekamp. "Angiotensin-Converting Enzyme Inhibition Does Not Correct Early Defects in Renal and Vascular Permeability in Diabetes Mellitus." Clinical Science 94, no. 2 (1998): 165–73. http://dx.doi.org/10.1042/cs0940165.

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1. In diabetes mellitus a selective increase in the excretion of albumin generally precedes the occurrence of demonstrable loss of glomerular size-selectivity. However, even in this (microalbuminuric) phase of diabetic nephropathy a defect in glomerular barrier function can be demonstrated during infusion of atrial natriuretic peptide. 2. The aim of this study was to investigate whether angiotensin-converting enzyme inhibition could prevent the proteinuric response to atrial natriuretic peptide in these patients. We performed infusions of atrial natriuretic peptide (0.01 μg min−1 kg−1) in 10 p

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14

Hamaamin, Karmand Salih, and Naza Mohammed Ali Mahmood. "Anti-inflammatory Role of Blocking the Renin-angiotensin System: Future Prospective." Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) 3 (November 26, 2022): 75–81. http://dx.doi.org/10.54133/ajms.v3i.89.

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The renin-angiotensin system (RAS) was thought to be in charge of managing blood pressure and electrolytes. It has been established that angiotensin II is also responsible for controlling inflammation in addition to blood pressure and potassium levels. Angiotensin converting enzyme 2 (ACE2), angiotensins (1–7), angiotensins (1–9), and other additional RAS components have been identified, and have anti-angiotensin II effects. Both angiotensin receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEIs) are utilized as anti-hypertensive medications and protecting the heart and k

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15

Jiang, Fan, Jianmin Yang, Yongtao Zhang, et al. "Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets." Nature Reviews Cardiology 11, no. 7 (2014): 413–26. http://dx.doi.org/10.1038/nrcardio.2014.59.

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16

Cohall, Damian, Nkemcho Ojeh, Carlos M. Ferrario, O. Peter Adams, and Marcella Nunez-Smith. "Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?" Journal of the Renin-Angiotensin-Aldosterone System 21, no. 1 (2020): 147032032090818. http://dx.doi.org/10.1177/1470320320908186.

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Introduction: Low plasma renin activity hypertension is prevalent in Afro-Caribbean persons. Reduced angiotensin converting enzyme 2 activity from the counter angiotensin converting enzyme 2 /angiotensin-(1-7)/Mas receptor axis of the renin angiotensin aldosterone system has been reported in people with pre-hypertension, type 2 diabetes mellitus and chronic renal disease. This study investigates whether an imbalance in the regulatory mechanisms between the pressor arm of the renin angiotensin aldosterone system (angiotensin converting enzyme/angiotensin II/AT1 receptor) and the depressor axis

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17

Afifah, Nisa Nur, Yani Mulyani, and Ari Yuniarto. "Review: Pengaruh Tanaman Obat Yang Beraktivitas Hipertensi Terhadap Ekspresi Gen Reseptor ACE-1 dan ACE 2." Jurnal Mandala Pharmacon Indonesia 7, no. 1 (2021): 9–31. http://dx.doi.org/10.35311/jmpi.v7i1.64.

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Hipertensi adalah salah satu penyakit dengan angka kesakitan dan kematian yang terus meningkat, termasuk di Indonesia. Dalam mengatasi hipertensi obat-obatan seperti ACE inhibitor berperan dalam menurunkan tekanan darah diastol dan sistol, namun tanaman obat seperti ekstrak buah hawthorn, buah zaitun (Olea europaea L.), Hibiscus Sabdariffa, Allium Sativum dan Allium Cepa juga memiliki efek sebagai antihipertensi dengan harga yang relatif murah, mudah didapat, efek samping yang lebih rendah dibandingkan dengan obat sintesis atau kimia lainnya. Review jurnal ini ditujukan untuk mengetahui berbag

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18

Dettlaff-Pokora, Agnieszka, and Julian Swierczynski. "Dysregulation of the Renin-Angiotensin-Aldosterone System (RAA) in Patients Infected with SARS-CoV-2-Possible Clinical Consequences." International Journal of Molecular Sciences 22, no. 9 (2021): 4503. http://dx.doi.org/10.3390/ijms22094503.

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SARS-CoV-2 impairs the renin-angiotensin-aledosterone system via binding ACE2 enzyme. ACE2 plays a key role in the biosynthesis of angiotensin (1-7), catalyzing the conversion of angiotensin 2 into angiotensin (1-7) and the reaction of angiotensin synthesis (1-9), from which angiotensin is (1-7) produced under the influence of ACE (Angiotensin-Converting Enzyme). Angiotensin 2 is a potent vasoconstrictor and atherogenic molecule converted by ACE2 to reducing inflammation and vasodilating in action angiotensin (1-7). Angiotensin (1-9), that is a product of angiotensin 1 metabolism and precursor

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19

Feitosa, Lauro César Soares, Alécio Matos Pereira, Adeline Andrade Carvalho, Antônio de Sousa Junior, Kinulpe Honorato-Sampaio, and Amilton Paulo Raposo Costa. "Immunolocalization of angiotensin-(1-7), angiotensin II and angiotensin-converting enzyme 2 in goat ovary." Acta Veterinaria Brasilica 15, no. 3 (2021): 180–83. http://dx.doi.org/10.21708/avb.2021.15.3.9629.

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There is increasing evidence as to the participation of the ovarian renin-angiotensin system in important reproductive processes. The inhibition of the angiotensin-converting enzyme (ACE) caused an increase in the rate of ovulation and pregnancy in the artificial insemination protocol has fixed time (TFIA). This study aimed to investigate the presence and location of Ang II, Ang- (1-7) and ACE2 in goat ovaries and the possibility of the involvement of these peptides in previous results. Ten ovaries from goats were collected in a slaughterhouse, washed in buffered PBS, perfused with protease in

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20

Ozisik, Kanat, Muge Misirlioglu, Tulga A. Ulus, Serdar Tuncer, Mustafa Emir, and Fehmi Katircioglu. "Renin-Angiotensin System Polymorphisms and Coronary Artery Surgery Patients." Asian Cardiovascular and Thoracic Annals 13, no. 2 (2005): 153–56. http://dx.doi.org/10.1177/021849230501300212.

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The frequencies of angiotensin-converting enzyme gene insertion/deletion, angiotensinogen-M253T, and angiotensin II type 1 receptor-A1166C polymorphisms were analyzed in 105 patients undergoing coronary artery bypass grafting (group 1) and a control group of 105 non-cardiac patients (group 2). Blood samples were obtained for biochemical analyses and DNA extraction. Genotyping was performed by polymerase-chain-reaction-based restriction analysis. According to the angiotensin-converting enzyme gene insertion/deletion polymorphism, 36.3% of patients in group 1 and 30.7% in group 2 were homozygous

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21

Lage, Silvia G., Liliane Kopel, Caio C. J. Medeiros, Ricardo T. Carvalho, and Mark A. Creager. "Angiotensin II contributes to arterial compliance in congestive heart failure." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 4 (2002): H1424—H1429. http://dx.doi.org/10.1152/ajpheart.00820.2001.

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Arterial compliance is determined by structural factors, such as collagen and elastin, and functional factors, such as vasoactive neurohormones. To determine whether angiotensin II contributes to decreased arterial compliance in patients with heart failure, this study tested the hypothesis that administration of an angiotensin-converting enzyme inhibitor improves arterial compliance. Arterial compliance and stiffness were determined by measuring carotid artery diameter, using high-resolution duplex ultrasonography, and blood pressure in 23 patients with heart failure secondary to idiopathic di

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22

Wang, Jun Ming, Dirk Slembrouck, Junhui Tan, et al. "Presence of cellular renin-angiotensin system in chromaffin cells of bovine adrenal medulla." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 5 (2002): H1811—H1818. http://dx.doi.org/10.1152/ajpheart.01092.2001.

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The presence of a local renin-angiotensin system has been established in organs that serve as angiotensin targets. In this study, the expression of angiotensinogen mRNA and subcellular localization of renin, angiotensin-converting enzyme, and angiotensin II were investigated in bovine adrenal medullary cells in primary culture. By light microscopy, expression of angiotensinogen mRNA, immunoreactive renin, angiotensin-converting enzyme, and angiotensin II were readily detectable only in the chromaffin cells. The density distribution of renin and angiotensin II in sucrose gradients suggested a c

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23

Adhikari, Chandra Mani, Sujeeb Rajbhandari, Dipanker Prajapati, et al. "Medical Management of ST elevation Myocardial infarction - Where are we?" Nepalese Heart Journal 11, no. 1 (2014): 45–48. http://dx.doi.org/10.3126/njh.v11i1.10981.

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Background and Aims: Despite well developed guidelines in the management of ST elevation myocardial infarction, registries worldwide have demonstrated incomplete implementation of evidence-based recommendations. Our study aims to assess the adherence of our practices to the recommended clinical guidelines, which is based on the discharge prescription in Shahid Gangalal National Heart Centre. Methods: Medical records of 495 ST elevation myocardial infarction patients discharged from our centre in between January 2012 to December 2012 were retrospectively reviewed. Results: Among the 495 patient

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24

Miesbach, Wolfgang. "Pathological Role of Angiotensin II in Severe COVID-19." TH Open 04, no. 02 (2020): e138-e144. http://dx.doi.org/10.1055/s-0040-1713678.

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AbstractThe activated renin–angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin–angiotensin system and is degraded by the angiotensin-converting enzyme 2 to angiotensin (1–7). The novel coronavirus infection (classified as COVID-19) is caused by the new coronavirus SARS-CoV-2 and is characterized by an exaggerated inflammatory response that can lead to severe manifestations such as acute respiratory distress syndrome, sepsis, and death in a proportion of patien

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25

Wulandani, Baiq Rani Dewi, Endang Sutriswati Rahayu, Yustinus Marsono, and Tyas Utami. "Aktivitas Antioksidan Danangiotensin-I Converting Enzyme Inhibitor oleh Yogurt dengan Ekstrak Daun Ficus glomerata Roxb." Agritech 37, no. 3 (2018): 246. http://dx.doi.org/10.22146/agritech.10846.

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Ficus glomerata Roxb has been known to have flavonoids. Flavonoids in plant are known for their antioxidant activity and ability to the Angiotensin Converting Enzyme I- inhibitor. This research started with extraction using water on the leaves of Ficus glomerata Roxb to obtained profile of phenolic compounds in the leaves of Ficus glomerata Roxb [gallic acid, flavonol (quercetin dan rutin), flavanol (catechin), dan flavanone]. The next stage was to prepare of yogurt starter inoculation and propagation of starter yogurt and yogurt- making process with the addition of the leaf extract of Ficus g

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26

Jullien, Nicolas, Anastasios Makritis, Dimitris Georgiadis, Fabrice Beau, Athanasios Yiotakis, and Vincent Dive. "Phosphinic Tripeptides as Dual Angiotensin-Converting Enzyme C-Domain and Endothelin-Converting Enzyme-1 Inhibitors." Journal of Medicinal Chemistry 53, no. 1 (2010): 208–20. http://dx.doi.org/10.1021/jm9010803.

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27

Oboh, Ganiyu, Ayokunle O. Ademosun, Adedayo O. Ademiluyi, Olasunkanmi S. Omojokun, Esther E. Nwanna та Kuburat O. Longe. "In Vitro Studies on the Antioxidant Property and Inhibition of α-Amylase, α-Glucosidase, and Angiotensin I-Converting Enzyme by Polyphenol-Rich Extracts from Cocoa (Theobroma cacao) Bean". Pathology Research International 2014 (8 вересня 2014): 1–6. http://dx.doi.org/10.1155/2014/549287.

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Background. This study sought to investigate the antidiabetic and antihypertensive mechanisms of cocoa (Theobroma cacao) bean through inhibition of α-amylase, α-glucosidase, angiotensin-1 converting enzyme, and oxidative stress. Methodology. The total phenol and flavonoid contents of the water extractable phytochemicals from the powdered cocoa bean were determined and the effects of the extract on α-amylase, α-glucosidase, and angiotensin-1 converting enzyme activities were investigated in vitro. Furthermore, the radicals [1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2..-azino-bis(3-ethylbenzthiazo

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Yamada, Kazuo, Shridhar N. Iyer, Mark C. Chappell, Detlev Ganten, and Carlos M. Ferrario. "Converting Enzyme Determines Plasma Clearance of Angiotensin-(1–7)." Hypertension 32, no. 3 (1998): 496–502. http://dx.doi.org/10.1161/01.hyp.32.3.496.

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MAIER, LISA A, MARY V RAYNOLDS, DAVID A YOUNG, ELIZABETH A BARKER, and LEE S NEWMAN. "Angiotensin-1 Converting Enzyme Polymorphisms in Chronic Beryllium Disease." American Journal of Respiratory and Critical Care Medicine 159, no. 4 (1999): 1342–50. http://dx.doi.org/10.1164/ajrccm.159.4.9806106.

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30

Ahmad, Sarfaraz, Jasmina Varagic, Jessica L. VonCannon, et al. "Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme." Biochemical and Biophysical Research Communications 478, no. 2 (2016): 559–64. http://dx.doi.org/10.1016/j.bbrc.2016.07.100.

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Takemoto, Masao, Kensuke Egashira, Hideharu Tomita, et al. "Chronic Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade." Hypertension 30, no. 6 (1997): 1621–27. http://dx.doi.org/10.1161/01.hyp.30.6.1621.

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Millar, Evelyn A., Gordon T. McInnes та Neil C. Thomson. "Investigation of the Mechanism of β2-Agonist-Induced Activation of the Renin—Angiotensin System". Clinical Science 88, № 4 (1995): 433–37. http://dx.doi.org/10.1042/cs0880433.

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1. We have previously described activation of the renin—angiotensin system in asthma, and also by high-dose nebulized β2-agonists. In this study we sought to determine the mechanism responsible. 2. The influence of the angiotensin-converting enzyme inhibitor, lisinopril, on the response of the renin—angiotensin system and serum potassium to nebulized salbutamol was investigated in a randomized, double-blind, crossover study in eight healthy volunteers using a factorial block design. On study days, subjects received lisinopril 20 mg orally or identical placebo tablets followed 3 h later by nebu

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Kluskens, Leon D., S. Adriaan Nelemans, Rick Rink, et al. "Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog." Journal of Pharmacology and Experimental Therapeutics 328, no. 3 (2008): 849–54. http://dx.doi.org/10.1124/jpet.108.146431.

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34

Wapstra, Frits H., Harry Van Goor, Gerjan Navis, Paul E. De Jong, and Dick De Zeeuw. "Antiproteinuric Effect Predicts Renal Protection by Angiotensin-Converting Enzyme Inhibition in Rats with Established Adriamycin Nephrosis." Clinical Science 90, no. 5 (1996): 393–401. http://dx.doi.org/10.1042/cs0900393.

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1. The mechanism of renal protection by angiotensin-converting enzyme inhibition is still the subject of debate. Inhibition of proteinuria might play a role. If so, a good antiproteinuric response to angiotensin-converting enzyme inhibition should predict subsequent protection against renal structural damage. This hypothesis has not been tested in models where treatment is started after the renal disease is well established, i.e. models that mimic the clinical situation. 2. We therefore investigated this hypothesis in 96 male Wistar rats with established adriamycin nephrosis. Reduction of prot

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Szentes, Veronika, Gabriella Kovács, and Csaba András Dézsi. "Domestic practice of antihypertensive treatment of diabetic hypertensive patients." Orvosi Hetilap 155, no. 43 (2014): 1695–700. http://dx.doi.org/10.1556/oh.2014.29988.

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Diabetes mellitus as comorbidity is present in 20–25% of patients suffering from high blood pressure. Because simultaneous presence of these two diseases results in a significant increase of cardiovascular risk, various guidelines focus greatly on the anti-hyperintensive treatment of patients with diabetes. Combined drug therapy is usually required to achieve the blood pressure target value of <140/85 mmHg defined for patients with diabetes, which must be based on angiotensin converting enzyme-inhibitors or angiotensin receptor blockers. These can be/must be combined with low dose, primaril

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Nussberger, J., D. B. Brunner, B. Waeber, J. Biollaz, and Hans R. Brunner. "Lack of angiotensin I accumulation after converting enzyme blockade by enalapril or lisinopril in man." Clinical Science 72, no. 3 (1987): 387–89. http://dx.doi.org/10.1042/cs0720387.

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1. In nine normal volunteers, a series of five venous blood samples was obtained before and up to 24 h after converting enzyme inhibition by a single oral dose of enalapril or lisinopril. Plasma renin activity and blood angiotensin I were measured. 2. A close linear relationship was found between the increase in plasma renin activity and the increase in blood angiotensin I. 3. The linear correlation between plasma renin activity and blood angiotensin I remained after converting enzyme inhibition. 4. Thus, the rise in angiotensin I after inhibition of the conversion of angiotensin I to angioten

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Lu, XinZheng, Yi Gu, Xiao-Hui Yang, et al. "Correlation between plasma-soluble angiotensin-converting enzyme 2, anti- angiotensin-converting enzyme 2, and angiotensin-(1–7) in patients with chronic heart failure." Cardiology Plus 4, no. 1 (2019): 22. http://dx.doi.org/10.4103/cp.cp_3_19.

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38

Clarke, Nicola E., and Anthony J. Turner. "Angiotensin-Converting Enzyme 2: The First Decade." International Journal of Hypertension 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/307315.

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The renin-angiotensin system (RAS) is a critical regulator of hypertension, primarily through the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin-converting enzyme (ACE) mediating an increase in blood pressure. The discovery of ACE2, which primarily metabolises Ang II into the vasodilatory Ang-(1-7), has added a new dimension to the traditional RAS. As a result there has been huge interest in ACE2 over the past decade as a potential therapeutic for lowering blood pressure, especially elevation resulting from excess Ang II. Studies focusing on ACE2 have

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Nalesnik, E. O. "Angiotensin-converting enzyme: a well-known stranger. Part I." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 29, no. 4 (2023): 353–70. http://dx.doi.org/10.18705/1607-419x-2023-29-4-353-370.

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The angiotensin-converting enzyme (ACE) was discovered in 1956 and has been actively studied to date. It has a unique structure of two homologous domains, each containing a catalytic zinc ion. Domains have different substrate specificity. In terms of function, ACE is a zinc metallopeptidase widely present on the surface of endothelial and epithelial cells. The gene encoding ACE is located on the long arm of chromosome 17 (17q23) and is 21 kb long, including 26 exons and 25 introns. The structure of ACE may be the result of an ancient gene duplication that occurred approximately 700 million yea

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Chenna, Avantika, Venu Madhav Konala, Subhasish Bose, et al. "Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade." Case Reports in Nephrology 2020 (June 29, 2020): 1–8. http://dx.doi.org/10.1155/2020/8811931.

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The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage. There have been controversial hypotheses raised regarding the safety of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in COVID-19 (coronavirus disease 2019). We present the case series of four patients (2 men and 2 women; 1 Caucasian and 3 African Americans; two survived and two died) with confirmed COVID-19, presenting with respiratory sym

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Baltatu, Ovidiu, Mihai Todiras, and Michael Bader. "Vasorelaxation to Angiotensin I After Angiotensin Converting Enzyme Inhibition." Hypertension 36, suppl_1 (2000): 695. http://dx.doi.org/10.1161/hyp.36.suppl_1.695-c.

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P14 We aimed at studying the vasoactive function of angiotensin I (Ang I) degradation products in the absence of tissue ACE (angiotensin-converting enzyme) activity. The effect of Ang I on captopril (10 -5 M)-treated rat aortic rings pre-contracted with phenylephrine (Phe, 10 -7 M) was studied. Mechanism of action of Ang I degradation products were analyzed using Ang-receptor antagonists [D-Ala 7 - Ang-(1-7), A779 - Ang-(1-7)-selective; PD123319, PD - AT 2 receptor specific; Sar 1 -Thr 8 -Ang II, sarthran - nonspecific), bradykinin B 2 receptor antagonist (HOE140) and inhibitors of neutral end

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Morawietz, H., W. Goettsch, M. Szibor, et al. "Angiotensin-converting enzyme inhibitor therapy prevents upregulation of endothelin-converting enzyme-1 in failing human myocardium." Biochemical and Biophysical Research Communications 295, no. 5 (2002): 1057–61. http://dx.doi.org/10.1016/s0006-291x(02)00799-4.

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Gokhale, Nikhil H., and J. A. Cowan. "Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: toward dual-action therapeutics." JBIC Journal of Biological Inorganic Chemistry 11, no. 7 (2006): 937–47. http://dx.doi.org/10.1007/s00775-006-0145-2.

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GUAZZI, Marco, and Piergiuseppe AGOSTONI. "Angiotensin-converting enzyme inhibition restores the diffusing capacity for carbon monoxide in patients with chronic heart failure by improving the molecular diffusion across the alveolar capillary membrane." Clinical Science 96, no. 1 (1999): 17–22. http://dx.doi.org/10.1042/cs0960017.

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Conductance of alveolar capillary membrane (DM) and capillary blood volume (VC) are the subcomponents of the pulmonary diffusing capacity for carbon monoxide (DLco). In chronic heart failure, stress failure of the membrane provides a mechanism for reduced DM and subsequent impairment of DLco. Angiotensin-converting enzyme inhibition improves DLco in patients with chronic heart failure. This study was aimed at investigating which of the two subcomponents of DLco is affected by angiotensin-converting enzyme inhibitors. Twenty-seven patients with NYHA class II to III chronic heart failure (group

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Trevisan, Andrea, Ornella Troso, and Stefano Maso. "Recovery of Biochemical Changes Induced by 1, 2-Dichloro propane in Rat Liver and Kidney." Human & Experimental Toxicology 10, no. 4 (1991): 241–44. http://dx.doi.org/10.1177/096032719101000402.

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1 Biochemical changes in male, Wistar rats, treated with different doses of 1,2-dichloropropane (50-500 mg kg-1 body weight), were investigated at the end of a 4-week treatment and after a 4-week recovery period. 2 The behaviour of Phase I and Phase II metabolic steps and of the angiotensin converting enzyme activity of the renal proximal tubule brush border were determined. 3 Phase II is more affected by the solvent than Phase I metabolism, and liver metabolism is more affected than the kidney. 4 Angiotensin converting enzyme activity from the proximal tubule brush border appears to be the mo

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Bennett, Michael A., and Herbert Thurston. "Effect of Angiotensin-Converting Enzyme Inhibitors on Resistance Artery Structure and Endothelium-Dependent Relaxation in Two-Kidney, One-Clip Goldblatt Hypertensive and Sham-Operated Rats." Clinical Science 90, no. 1 (1996): 21–29. http://dx.doi.org/10.1042/cs0900021.

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1. This study was designed to examine the effect of angiotensin-converting enzyme inhibitors on resistance artery structure and endothelium-dependent relaxation in Goldblatt two-kidney, one-clip hypertensive rats. Four weeks after clipping, hypertensive and sham rats were treated with either perindopril (1 mg day−1 kg−1) or quinapril (3 or 30mg day−1 kg−1). After 6 weeks mesenteric resistance arteries were mounted in a myograph for measurements of vascular structure. The endothelium-dependent relaxation response to acetylcholine and bradykinin and the response to the nitric oxide donor sodium

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Ali, Sajid, Muhammad Tariq Mehr, Muhammad Bilal, Muhammad Zubair, Ahmad Shamim Khan, and Noreen Mehmood. "Angiotensin 1 Converting Enzyme Encoding Gene Polymorphism in Renal Patients." Pakistan Journal of Medical and Health Sciences 16, no. 8 (2022): 890–93. http://dx.doi.org/10.53350/pjmhs22168890.

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Background: Angiotensin I is converted to angiotensin II by an angiotensin-converting enzyme, which is an important component of renin-angiotensin framework. Multifactorial chronic kidney disease includes risk factors such as hypertension, obesity, inherited factors, and diabetes. A genetic factor associated with premature signs of renal failure is predominantly increased arterial hypertension and albumin excretion, which add to the pathophysiological movement of disintegration in renal capacity. This enzymatic assay aimed to detect ACE levels in various renal patients compared with controls t

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Zaheer, Sarah, Jenifer M. Brown, Molly Connors, Jonathan S. Williams, Gail K. Adler, and Anand Vaidya. "Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion." International Journal of Endocrinology 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/4138783.

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Background. Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion. Objective. To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in participants with and without primary hyperparathyroidism (P-HPT). Methods. An open-label, single-arm, pilot study whereby participants with and without P-HPT had PTH were evaluated before and after 1 week of maximally tolerated lisinopril therapy. Results. A total of 12 participants with, and 15 participants without, P-HPT successfully completed the protoc

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Ferreira, Anderson J., Robson A. S. Santos, and Mohan K. Raizada. "Angiotensin-(1-7)/Angiotensin-Converting Enzyme 2/Mas Receptor Axis and Related Mechanisms." International Journal of Hypertension 2012 (2012): 1–2. http://dx.doi.org/10.1155/2012/690785.

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Bernardi, Stella, Wendy C. Burns, Barbara Toffoli, et al. "Angiotensin-converting enzyme 2 regulates renal atrial natriuretic peptide through angiotensin-(1–7)." Clinical Science 123, no. 1 (2012): 29–37. http://dx.doi.org/10.1042/cs20110403.

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Deficiency of ACE2 (angiotensin-converting enzyme 2), which degrades Ang (angiotensin) II, promotes the development of glomerular lesions. However, the mechanisms explaining why the reduction in ACE2 is associated with the development of glomerular lesions have still to be fully clarified. We hypothesized that ACE2 may regulate the renoprotective actions of ANP (atrial natriuretic peptide). The aim of the present study was to investigate the effect of ACE2 deficiency on the renal production of ANP. We evaluated molecular and structural abnormalities, as well as the expression of ANP in the kid

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