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Dissertations / Theses on the topic 'Animal stroke models'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Yu, Xinge. "Stroke Study: Novel Animal Models and Innovative Treatment Strategy." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1450735023.

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2

Rakai, Brooke D., and University of Lethbridge Faculty of Arts and Science. "Experience dependent plasticity of stroke outcome." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2008, 2008. http://hdl.handle.net/10133/2518.

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Stroke outcome is highly variable. Experiments in this thesis test the hypothesis that experience prior to a stroke is an important variable in the manifestation of stroke. Optokinetic tracking was used to evaluate the effects of visual cortex stroke and MCA occlusion in rats. Normal laboratory rats showed a small, but significant decrease in tracking thresholds following visual cortex stroke. Animals with developmental visuomotor experience or reach training experience in adulthood, however, had tracking thresholds which were substantially increased, and the effects of visual cortex strokes w

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3

Sena, Emily Shamiso. "Systematic review and meta-analysis of animal models of acute ischaemic stroke." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4824.

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Ischaemic stroke is responsible for substantial death and disability and creates a huge financial burden for healthcare budgets worldwide. At present there are few effective treatments for acute stroke and these are urgently required. Increased understanding of the ischaemic cascade has generated interest in neuroprotection for focal cerebral ischaemia. However, treatment effects observed in of over 500 interventions in animal models have yet to be translated to the clinic. Systematic review and meta-analysis allows unbiased identification of all relevant data for a given intervention, gives a

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4

Rakers, Cordula Marijke [Verfasser]. "The role of glial calcium changes in animal models of stroke / Cordula Marijke Rakers." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1121105599/34.

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5

Marc, Vani. "Establishing a Model to Label and Stimulate Cells Active During Motor Behaviour." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38066.

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The remapping of cortical networks after stroke is hypothesized to be one of the mechanisms subserving functional recovery. Our understanding of cortical remapping remains limited due to the inability to resolve which cells are active while performing motor tasks with high temporal and spatial specificity. The experiments presented in the first chapter of this thesis evaluate the ability of the inducible Arc-CreERT2:Rosa-YFPf/f model to label cells in the motor cortex activated by a motor-related behaviour. Through the modification of previously published 4-hydroxytamoxifen treatment paradi

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6

Brevard, Mathew E. "Developing Compatible Techniques for Magnetic Resonance Imaging of Stroke Pathophysiology." Digital WPI, 2001. https://digitalcommons.wpi.edu/etd-theses/20.

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Stroke is the most prevalent neurological disease facing our nation today. Treatments, however, are few and insufficient at reducing the impact of this neurological condition. Experimental animal models are important to improving our understanding of stroke, and for developing new therapies to counter the pathology of stroke. Magnetic Resonance Imaging is the leading tool for the non-invasive investigation of stroke pathophysiology. While most MRI work in animals is conducted under anesthesia, anesthesia has profound effects on cerebral circulation and metabolism, and can affect stroke outcome

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7

Chan, Chu-fung, and 陳柱峰. "Neuroprotective effects of granulocyte-colony stimulating factor in a mice stroke model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B40687284.

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8

Kirkland, Scott, and University of Lethbridge Faculty of Arts and Science. "Modulation of recovery and compensation after stroke." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007, 2007. http://hdl.handle.net/10133/387.

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Stress has been shown to exacerbate cell death and cognitive deficits after ischemic injury in rodents, however, little is known of the effects of stress on motor recovery. The objective of this present thesis is to examine the effects of chronic stress on skilled motor recovery after devascularization lesion in rats. It was found that pre-lesion stress induced the most behavioural impairments, while post-lesion stress exacerbated infarct volume. The effects of chronic multiple stress on skilled motor recovery after lesion was also examined. Chronic multiple stress did not modulate skilled mot

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9

Silasi, Gergely, and University of Lethbridge Faculty of Arts and Science. "Novel treatments for inducing cortical plasticity and functional restitution following motor cortex stroke." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005, 2005. http://hdl.handle.net/10133/278.

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Stroke remains a leading cause of disability in the western world, with symptoms ranging in severity from mild congnitive or motor impairments, to severe impairments in both cognitive and motor domains. Despite ongoing research aimed at helping stroke patients the disease cannot be prevented or cured, therefore a large body of research has been aimed at identifying effective rehabilitative strategies. Based on our understanding of normal brain function, and the meachanisms mediating the limited spontaneous recovery that is observed following injury, factors that promote brain plasticity are li

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10

Gharbawie, Omar A., and University of Lethbridge Faculty of Arts and Science. "Modeling middle cerebral artery stroke in rats : an examination of the skilled reaching impairments." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006, 2006. http://hdl.handle.net/10133/388.

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Middle cerebral artery (MCA) stroke can produce chronic incapacitating motor impairments. Understanding the neural basis of the motor syndromes is complicated by the diversity of neural structures damaged but the problem can be addressed in laboratory rats by inducing selective infarcts. Nevertheless, the motor syndromes that ensue from stroke in rats remain poorly understood and undermine its potential as a model for clinical stroke. The objective of the present thesis was to document the skilled reaching impairments from neocortical and subcortical MCA infarcts in rats. In addition, the inte

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11

Gidyk, Darryl C. "Modulation of compensation and recovery in a rat model of motor cortex stroke : implications of transcranial direct current stimulation." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011, 2011. http://hdl.handle.net/10133/3236.

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The present thesis examines the effects of transcranial direct current stimulation and forelimb rehabilitation on motor recovery after stroke in rats. Post-stroke motor outcomes were quantified using an innovative battery of behavioural tests and high resolution, in vivo electrophysiology was employed to examine coherence of neural activity between hemispheres. It was shown that rats that received brain stimulation concurrently with forelimb rehabilitation displayed functional recovery, whereas rats that received rehabilitation alone partially regained motor function, but the improvements were

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12

Farr, Tracy Deanne, and University of Lethbridge Faculty of Arts and Science. "A mouse model for studying stroke induced impairments, recovery, and compensation in the motor cortex." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, 2003. http://hdl.handle.net/10133/156.

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Stroke is the third leading cause of death and survivors suffer motor impairments. The rodent sensorimotor system is similar to the human's, making rodents a good model to study the effects of stroke. Transgenic technology makes the mouse a desirable stroke model, however, there are few behavioural tests to assess behavioural outcome. This thesis evaluates mice subjected to permanent or temporary occlusion focal motor cortex strokes in a skilled reaching task. The first experiment documents changes in skilled movements in mice with a permanent occlusion focal motor cortex stroke. The second ex

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13

Karthikeyan, Sai Sudarshan. "Characterization of Spontaneous Motor Recovery and Changes in Plasticity-Limiting Perineuronal Nets Following Cortical and Subcortical Stroke." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36812.

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Stroke is a leading cause of neurological disability, often resulting in long-term motor impairments due to damage to the striatum and/or motor cortex. While both humans and animals show spontaneous recovery following stroke, little is known about how the injury location affects recovery and what causes recovery to plateau. This information is essential in order to improve current rehabilitation practice and develop new therapies to enhance recovery. In this thesis, we used endothelin-1 (ET-1), a potent vasoconstrictor, to produce focal infarcts in the forelimb motor cortex (FMC), the dorsolat

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14

Brodin, Camille. "De la paillasse au lit du patient, surmonter les problèmes de translation dans le domaine de l'AVC ischémique Single- and two- chain tissue plasminogen activator treatment differentially influence cerebral recovery after stroke Single- and two- chain tissue plasminogen activator treatment differentially influence cerebral recovery after stroke Cerebral blood flow correlates with ischemic brain lesion only when Stroke occurs awake: a preclinical model to bypass the translational roadblocks to clinic." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC427.

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Les défauts de translation des études précliniques vers les essais cliniques dans le domaine des AVC ischémiques et l'échec des développements thérapeutiques pourraient être expliqués par trois aspects : (1) le manque de compréhension des mécanismes des deux formes de rtPA, le traitement pharmacologique de l'AVC; (2) le manque d'outils adaptés d'imagerie de perfusion chez le petit animal et (3) l'influence de l'anesthésie sur l’effet des traitements testés dans les modèles animaux.Le tPA utilisé en clinique (Actilyse®) est un mélange de deux formes de tPA: une forme chaîne simple (sc-rtPA) et

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15

Jeffs, Graham J. "The effect of sodium/calcium exchanger 3 (NCX3) knockout on neuronal survival following global cerebral ischaemia in mice." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0063.

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Cerebral ischaemia is a leading cause of disability and death world-wide. The only effective treatments are thrombolytic therapy (plasminogen activator; tPA) and hypothermia (33?C). However, tPA has limited clinical application due to its short therapeutic time window and its specific application in thrombo-embolic stroke. Moderate hypothermia (33?C) is only being used following cardiac arrest in comatose survivors. Hence more treatments are urgently required. The first step in developing new treatments is the identification and characterisation of a potential therapeutic target. Since brain d

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16

Ferreira, Guilherme José Bolzani de Campos. "Modelo experimental de acidente vascular encefálico (AVE)." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-24032008-141559/.

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Foi desenvolvido um modelo experimental de Acidente Vascular Encéfalo Isquêmico (AVE) em suínos utilizando seis animais jovens, oriundos de granjas da região da Grande São Paulo, com 20kg de peso vivo em média, sendo todas fêmeas e hígidas. Estes foram submetidos a sedação com Quetamina (5mg/kg), Midazolan (0,5mg/kg) e Fentanil (0,005mg/kg) por via intramuscular e posteriormente intubados via oro - traqueal. A manutenção anestésica foi realizada utilizando isoflurano (vaporizador calibrado a 1,5%). Puncionou-se uma veia auricular para fluido e medicação de emergência se necessário. Os animais

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17

Bailey, Emma Louise. "Pathophysiology of lacunar stroke : ischaemic stroke or blood brain barrier dysfunction?" Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6529.

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Lacunar strokes account for approximately a quarter of all ischaemic strokes and traditionally are thought to result from occlusion of a small deep perforating arteriole in the brain. Lacunar infarcts can be up to 2cm in diameter and are found in deep brain structures such as the thalamus and internal capsule. Despite their prevalence and specific accompanying clinical syndromes, the cause of lacunar stroke and its associated vascular pathology remain unclear. Many hypotheses as to the cause exist, which fall broadly into two categories; firstly, a direct occlusion via emboli or thrombus usual

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18

Basuodan, Reem Mohammed A. "Modelling perinatal stroke and stem cell grafting in a neonatal rat : modelling and treating perinatal stroke in an animal model." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4088.

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Perinatal ischemic stroke (PIS) in humans occurs mostly at full term and is a significant cause of hemiplegic cerebral palsy. A suitable animal model is needed to test early intervention therapies. Firstly, we developed and compared two PIS Models; middle cerebral artery occlusion (MCAO) at the level of the temporal bone, and the injection of reversible vasoconstrictor endothelin-1 (ET-1) into the sensorimotor cortex (SMC), at postnatal day (P) 12. Appropriate sham procedures were performed. Animals underwent behavioural testing (cylinder and grid walking tests) at P35-40 followed by immunohis

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19

Casals, Juliana Barbosa. "Modelo de acidente vascular encefálico em coelho para o uso de terapia celular." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-04042012-161055/.

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O Acidente Vascular Encefálico (AVE) é a segunda causa de morte mundial, anualmente mais de 20 milhões de indivíduos são acometidos por esta patologia, 5 milhões destes vão a óbito. No Brasil, é a principal causa de morte. Pesquisas demonstram que é crescente o uso de inúmeros modelos animais validos em pesquisas que buscam terapias funcionais para os Acidentes Vasculares. Numerosas espécies são usadas, ratos, coelhos, caninos, suínos, ovelhas e espécies de primatas. Um grande número de estudos tem sido realizado com células-tronco de diferentes fontes em diferentes modelos animais de lesão me

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20

Maillé, Sébastien. "Homeostatic-like Potentiation of the Aversive Habenulo-raphe Pathway in an Animal Model of Post-stroke Depression." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37287.

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Stroke is the third leading cause of death and the primary cause of adult long-term disability in Canada. Despite advances in rehabilitation research, stroke survivors experience an unusually high incidence of depressive symptoms which undermine recovery outcomes by reducing patient motivation levels. Human and animal studies have linked the incidence of post-stroke depression and the extent of prefrontal cortex (PFC) damage. The PFC and the lateral habenula (LHb) are limbic structures that are strongly connected to the serotonergic dorsal raphe nucleus (DRN), a key neuronal hub for mood regul

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21

Fadhel, Zainab. "Stroke-induced stem cells proliferation in normal versus diabetic mice and pharmacological regulation." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-36776.

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Introduction: Stroke is caused from the occlusion of any cerebral artery leading to cerebral ischemia, brain damage and consequent neurological impairments and disability. The primary causes of mortality in western populations is stroke. Diabetes type 2 is a high risk factor for stroke. Stroke leads to an observable increase of neural stem cell proliferation in the subventricular zone and enhances neurogenesis in the adult rodent and human brain which suggest a mechanism contributing to stroke recovery. Neurogenesis in type 2 diabetes patients is impaired. However, whether stroke-induced neuro

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22

Romanelli, Elisa [Verfasser], and Hans [Akademischer Betreuer] Straka. "In vivo insights into the pathogenesis of demyelinaton in multiple sclerosis and its animal model / Elisa Romanelli ; Betreuer: Hans Straka." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1122435762/34.

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23

Durand, Anne. "Caractérisation par IRM précoce de la synergie tPA - inhibiteur du TAFI dans un modèle d'ischémie focale thromboembolique murin." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10320/document.

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L'efficacité du rtPA dans le traitement de l’ischémie aigue est bien reconnue avec des effets secondaires graves nécessitant l’évaluation d’autres stratégies. Un modèle d’ischémie cérébrale focale a été décrit, réalisé par injection in situ de thrombine. Dans notre première étude, nous avons utilisé l’imagerie par résonance magnétique multimodale pour documenter les lésions et les zones de pénombre dans ce modèle. Malgré une occlusion de l’artère reproductible et une hypoperfusion marquée chez tous les sujets, une reperfusion spontanée est constatée dans 38% des cas, rendant l’IRM incontournab

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24

Wells, Adam James. "A surgical model of middle cerebral artery occlusive stroke in the sheep." Thesis, 2014. http://hdl.handle.net/2440/91277.

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Background: Stroke is an acute neurological injury secondary to vascular pathology, and is the second biggest killer of Australians and the leading cause of adult disability. The rationale of current therapy for occlusive stroke is rapid reperfusion of the ischaemic brain to limit the size of the injury. However, there are no standard neuroprotective therapies that have proven to be beneficial in clinical stroke, despite in excess of 1000 novel drugs showing promise in preclinical rodent studies. The consistent failure of clinical translation in rodent models suggests that they are perhaps not

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25

Winderlich, Joshua Nathan. "Molecular and Cellular Investigations Relating to Neuroplasticity in Stroke." Thesis, 2018. http://hdl.handle.net/2440/127109.

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Stroke is a leading cause of death and the leading cause of adult neurological disability in Australia. The interventions currently available for the management of stroke include intravenous thrombolysis, thombectomy, decompressive hemicraniectomy, antithrombotic therapy, stroke unit care and rehabilitation. The aims of these interventions are to reduce the amount of damage caused by stroke and to support recovery. Currently, there is no method to reverse the damage caused by stroke. The pattern of functional recovery following stroke reveals a critical period of enhanced neuroplasticity. This

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26

Murtha, Lucy. "The effects and mechanisms of therapeutic hypothermia on intracranial pressure regulation following ischaemic stroke in rats." Thesis, 2015. http://hdl.handle.net/1959.13/1310597.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Background: Intracranial pressure (ICP) rises to dangerous levels 2‐5 days after large ischaemic stroke. ICP following small stroke is not routinely monitored, although animal data suggests ICP rises 24 hours following small experimental stroke. Cerebral oedema has been thought to be the primary cause for ICP elevation. This assumption may have risen because ICP has only been monitored in patients with large infarct and oedema volumes. Since small ischaemic infarcts cause less cerebral swelling, ICP elevation may be the result of a different m

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27

"Potential of serotonin in stem cell technology and therapy in a mouse ischemic stroke model." 2012. http://library.cuhk.edu.hk/record=b5549580.

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Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in the embryonic neural development and adult neurogenesis. But the effects of 5-HT on stem cells are not fully known. In this study, the effects and underlying signal pathways of 5- HT on proliferation and neural differentiation of mouse embryonic stem (ES) cells, neural progenitor (NP) cell line C 17.2 and embryonic neural stem (NS) cells were explored. Molecular analysis, immunostaining and western blotting revealed that NP/NB cells expressed the rate-limiting enzyme tryptophan hydroxylase (TPH) and produced endogenous 5-H

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28

"Baicalin-mediated neuronal induction of neural stem cells and improvement of cognitive function in a mouse stroke model." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074973.

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Baicalin, which is a flavonoid, was previously shown to exert neuroprotective effects against ischemic injury and oxidative insults. In this study, baicalin was found to induce neuronal differentiation on both C17.2 NSC and primary mouse NSC originated from hippocampuses of E14.5 mouse embryos. The baicalin-mediated differentiation of C17.2 NSC was noted in dose- and time-dependent manners. Baicalin-treated NSC displayed long processes of neurites. The gene expression of neuronal markers, NF-L, TUBB3 and MAP2 was also significantly increased after treated with 20 to 50 muM baicalin on C17.2 NS

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29

CHEN, CHUNG-JEN, and 陳中仁. "Feline Acute Ischemic Stroke: Animal Model Development & Its Application In Magnetic Resonance Imaging." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/43731659889878530089.

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碩士<br>國立中興大學<br>獸醫學系<br>85<br>Magnetic resonance imaging (MRI) offers better soft tissue contrast than most other diagnostic imaging techniques. For this reason, it is fast becoming one of the most important clinical imaging techniques for the diagnosis of central nervous system in recent years. An appropriate animal model is essential for the study of etiology of all diseases. Further more, the brain ischemia and acute stroke is has become the leading cause of death in Taiwan recently. Yet

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30

Che-Chuan, Wang, and 王哲川. "Therapeutic evaluation of agmatine in middle cerebral artery occlusion induced stroke animal model : the rule of aquaporin 4." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/01789995492031301378.

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碩士<br>南台科技大學<br>生物科技系<br>97<br>Cerebral edema contributes to morbidity and mortality in stroke. The regulation of water balance in the brain is crucial. A disruption in this equilibrium causes an increase in brain water content that significantly contributes to the pathophysiology of traumatic brain injury, hydrocephalus, and a variety of neurological disorders. The discovery of the aquaporin (AQP) family of membrane water channels has provided important new insights into the physiology and pathology of brain water homeostasis. A number of recent studies are described in the review that demons

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31

Bugă, Ana-Maria [Verfasser]. "Cellular and molecular mechanisms underlying brain plasticity after stroke in animal model : role of aging / vorgelegt von: Ana-Maria Buga." 2008. http://d-nb.info/994739184/34.

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32

Keum, Sehoon. "Genetic Modifiers in Response to Ischemia." Diss., 2010. http://hdl.handle.net/10161/2291.

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<p>In a mouse model of ischemic stroke, infarct volume is highly variable and strain dependent, but the natural genetic determinants responsible for this difference remain unknown. To identify genetic determinants regulating ischemic neuronal damage and to dissect apart the role of individual genes and physiological mechanisms in infarction in mice, we performed forward genetic mapping analyses of surgically induced cerebral infarct volume. We have identified multiple quantitative trait loci (QTL) that modulate infarct volume, with a major locus (<italic>Civq1 </italic>) on chromosome 7 accoun

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33

Alves, Rita Beatriz Ruivo. "Mapping microstructural dynamics in a mouse stroke model using advanced diffusion MRI." Master's thesis, 2020. http://hdl.handle.net/10451/47972.

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Tese de mestrado integrado em Engenharia Biomédica e Biofísica (Sinais e Imagens Médicas), Universidade de Lisboa, Faculdade de Ciências, 2020<br>O acidente vascular cerebral (AVC) corresponde a uma das principais causas de morte e invalidez a nível mundial, sendo o AVC isquémico o mais predominante, perfazendo mais de 80% dos casos. Este traduz-se no bloqueio de um ou mais vasos sanguíneos devido à formação de coágulos, comprometendo a oxigenação no local e o fornecimento de nutrientes como consequência da redução do fluxo sanguíneo. O único tratamento aceite para o AVC baseia-se na administr

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