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Journal articles on the topic 'Animal studies dental implants'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Valdivia-Gandur, Iván, María Cristina Manzanares-Céspedes, Wilson Astudillo-Rozas, Oscar Aceituno-Antezana, Victòria Tallón-Walton, and Víctor Beltrán. "Simultaneous Osseo- and Odontointegration of Titanium Implants: Description of Two Cases in Human and Animal Models and Review of Their Experimental and Clinical Implications." Materials 17, no. 22 (2024): 5555. http://dx.doi.org/10.3390/ma17225555.

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Two cases of calcified bone and dental tissue integration with titanium implants are presented, along with a review of the literature on their experimental and clinical implications. First, histological analyses of a titanium implant extracted from a patient with iimplant disease revealed the integration of both dental and bone tissue on the implant’s surface. Secondly, a biocompatibility study in an animal model documented two implants in contact with tooth roots. Samples from both animal and human models demonstrated simultaneous osseointegration and dental tissue neoformation, with the latt

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Najeeb, Shariq, Zohaib Khurshid BDS, Sana Zohaib BDS, and Muhammad Sohail Zafar BDS. "Bioactivity and Osseointegration of PEEK Are Inferior to Those of Titanium: A Systematic Review." Journal of Oral Implantology 42, no. 6 (2016): 512–16. http://dx.doi.org/10.1563/aaid-joi-d-16-00072.

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Polyetheretherketone (PEEK) has been suggested as an alternative to replace titanium as a dental implant material. However, PEEK's bioactivity and osseointegration are debatable. This review has systematically analyzed studies that have compared PEEK (or PEEK-based) implants with titanium implants so that its feasibility as a possible replacement for titanium can be determined. The focused question was: “Are the bioactivity and osseointegration of PEEK implants comparable to or better than titanium implants?” Using the key words “dental implant,” “implant,” “polyetheretherketone,” “PEEK,” and

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López-Valverde, Nansi, Javier Flores-Fraile, Juan Manuel Ramírez, Bruno Macedo de Sousa, Silvia Herrero-Hernández, and Antonio López-Valverde. "Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review." Journal of Clinical Medicine 9, no. 7 (2020): 2047. http://dx.doi.org/10.3390/jcm9072047.

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Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Centr

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Arora, Himanshu, Anil Nafria, and Anup Kanase. "Rabbits as Animal Models in Contemporary Implant Biomaterial Research." World Journal of Dentistry 2, no. 2 (2011): 129–34. http://dx.doi.org/10.5005/jp-journals-10015-1069.

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ABSTRACT Development of an optimal interface between bone and orthopedic or dental implants has taken place for many years. In order to determine whether a newly developed implant material conforms to the requirements of biocompatibility, mechanical stability and safety, it must undergo rigorous testing both in vitro and in vivo. Results from in vitro studies can be difficult to extrapolate to the in vivo situation. For this reason the use of animal models is often an essential step in the testing of orthopedic and dental implants prior to clinical use in humans. This review discusses the reas

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Scarano, Antonio, Ahmad G. A. Khater, Sergio Alexandre Gehrke, Francesco Inchingolo, and Sergio Rexhep Tari. "Animal Models for Investigating Osseointegration: An Overview of Implant Research over the Last Three Decades." Journal of Functional Biomaterials 15, no. 4 (2024): 83. http://dx.doi.org/10.3390/jfb15040083.

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Dental implants and bone augmentation are among dentistry’s most prevalent surgical treatments; hence, many dental implant surfaces and bone grafts have been researched to improve bone response. Such new materials were radiologically, histologically, and histomorphometrically evaluated on animals before being used on humans. As a result, several studies used animals to evaluate novel implant technologies, biocompatibility, surgical techniques, and osseointegration strategies, as preclinical research on animal models is essential to evaluate bioactive principles (on cells, compounds, and implan

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Popescu, Sanda Mihaela, Horia Octavian Manolea, Oana Andreea Diaconu, et al. "Zirconia Biocompatibility in Animal Studies - A Systematic Review." Defect and Diffusion Forum 376 (July 2017): 12–28. http://dx.doi.org/10.4028/www.scientific.net/ddf.376.12.

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Zirconia is a metal used in dental implantology. Its biocompatibility was studied in vitro and in vivo, results of the studies being analyzed in reviews and meta analyses. The aim of this systematic review was to evaluate biocompatibility of zirconia in animal studies in vivo expressed as results of histomorphometric tests. Databases were searched from 1980 until February 2016, with different combination of the following MeSH terms: zirconium, biocompatibility, dental implants, in vivo, animal studies. Letters to the editors, case reports, commentaries, review articles and articles published i

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Erdogan, Özgür, Yakup Üstün, Ufuk Tatli, Ibrahim Damlar, and Kenan Daglıoglu. "A Pig Model for the Histomorphometric Evaluation of Hard Tissue Around Dental Implants." Journal of Oral Implantology 39, no. 5 (2013): 551–57. http://dx.doi.org/10.1563/aaid-joi-d-11-00009.

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This study aimed to evaluate the frontal bone of Swiss Domestic pigs as an animal model for the histologic-histomorphometric examination of bony tissue around dental implants. We inserted SLA surface implants 4.1 mm in diameter and 10 mm in length into the frontal bones of 9 Swiss-Domestic pigs. Histologic and histomorphometric studies were conducted on the undecalcified sections. Histologic examinations showed that the specimens contain a sufficient amount of bone to provide homogenous bone coverage for standard diameter dental implant placement. The mean bone to implant contact was 61.9% ± 8

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Wang, Yaling, Xianshuai Chen, Chunyu Zhang, et al. "Studies on the performance of selective laser melting porous dental implant by finite element model simulation, fatigue testing and in vivo experiments." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 233, no. 2 (2018): 170–80. http://dx.doi.org/10.1177/0954411918816114.

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Biomaterials have been widely used for stomatological reconstructive surgery in recent years. Many studies have demonstrated that the porous structure of an implant promotes bone ingrowth and its stiffness can be controlled via the design of the porosity. Although some researchers have paid attention to investigating the porous structure for dental implants, the biomechanical properties and osseointegration have not been well studied. In this study, finite element analysis and experiments have been used to evaluate the biomechanical performance and osseointegration of dental implants with poro

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Rismanchian, Mansour, Farshad Bajoghli, Tabakhian Gholamreza, and Mohamad Razavi. "Dental Implants: Early Versus Standard Two-Stage Loading (Animal Study)." Journal of Oral Implantology 40, no. 1 (2014): 84–92. http://dx.doi.org/10.1563/aaid-joi-d-10-00202.

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Direct bone formation on the implant surface is a treatment goal in implant dentistry. It was always thought that a healing period of 3 months for the lower jaw and 5–6 months for the upper jaw was required for osseointegration to occur. Recent studies, however, show that with the early loading protocol, osseointegration is possible as well. The goal of this study was to evaluate clinical, histologic, and histomorphometric parameters of implants with early loading protocols and implants that did not undergo the early loading protocol. In this experimental study, the first to the fourth premola

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Siddiqi, Allauddin, Abdul Samad Khan, and Sobia Zafar. "Thirty Years of Translational Research in Zirconia Dental Implants: A Systematic Review of the Literature." Journal of Oral Implantology 43, no. 4 (2017): 314–25. http://dx.doi.org/10.1563/aaid-joi-d-17-00016.

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Thirty years of transitional research in zirconia (Zr) ceramics has led to significant improvements in the biomedical field, especially in dental implantology. Oral implants made of yttria-tetragonal zirconia polycrystals (Y-TZP) because of their excellent mechanical properties, good biocompatibility, and esthetically acceptable color have emerged as an attractive metal-free alternative to titanium (Ti) implants. The aim of the review was to highlight the translation research in Zr dental implants that has been conducted over the past 3 decades using preclinical animal models. A computer searc

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Panda, Sourav, Margherita Tumedei, Sital Panda, et al. "The Biological Impact of Residual Aluminum Particles on Sand-Blasted Dental Implant Surfaces: A Systematic Review of Animal Studies." Applied Sciences 14, no. 17 (2024): 7745. http://dx.doi.org/10.3390/app14177745.

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(1) Background: The use of alumina particles for surface treatment of dental implants is a common practice aimed at enhancing osseointegration. However, the biological effects of residual alumina particles on implant surfaces remain a subject of debate. This systematic review evaluates the impact of residual alumina particles on the osseointegration, biocompatibility, and bacterial adhesion of dental implants based on available in vivo experimental animal studies. (2) Methods: A comprehensive literature search was conducted across PubMed, Web of Science, and Scopus to identify relevant studies

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Graves, Carmen V., Steve K. Harrel, Jeffrey A. Rossmann, et al. "The Role of Occlusion in the Dental Implant and Peri-implant Condition: A Review." Open Dentistry Journal 10, no. 1 (2016): 594–601. http://dx.doi.org/10.2174/1874210601610010594.

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Dental implants have become a widely used dental treatment approach. It is important to identify factors that can be detrimental to dental implants and the peri-implant complex. There is controversy regarding whether occlusion plays a role in the implant and peri-implant condition. The present study aims to review the scientific literature regarding this topic. Animal and human studies, and previous reviews on the topic are included and presented. There is a wide heterogeneity among study designs. Several articles demonstrated that occlusion and occlusion overload could detrimentally affect th

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Mele, Rocco E., Anthony Caiafa, and Gregori M. Kurtzman. "Dental Implants and Incisor Bridge Placement in a Dog." Journal of Veterinary Dentistry 33, no. 4 (2016): 249–58. http://dx.doi.org/10.1177/0898756416689348.

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Veterinary dentistry has tended to follow the trends and advancements in the human dental field. As for any procedure performed on a patient, whether human or animal, an informed decision is based on the available evidence regarding treatment options. This is certainly true for the more involved treatments in veterinary dentistry which can include the disciplines of endodontics and dental implantology. A number of published case reports have been accepted by the specialty that endodontic therapy is indeed a predictable and a valuable service that can be offered to pet owners. Oral implantology

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Rayannavar, Sounyala, Sunil Kumar MV, Vignesh Kamath, Mahantesh Bembalgi, Namratha Nayak, and Praveen Jodalli. "Osseointegrative and antimicrobial properties of graphene oxide nano coated dental implants: A systematic review." F1000Research 13 (August 9, 2024): 281. http://dx.doi.org/10.12688/f1000research.148180.2.

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Introduction Osseointegration stands as a pivotal concept within the realm of dental implants, signifying the intricate process through which a dental implant integrates with the adjoining bone tissue. Graphene oxide (GO) has been shown to promote osseointegration, the process by which the implant fuses with the surrounding bone. The objective of this study was to assess the osseointegrative and antimicrobial properties of GO nano coated dental implants. Methods A systematic search was conducted using electronic databases (e.g., PubMed, Scopus, Web of Science) to identify relevant studies publ

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Rayannavar, Sounyala, Sunil Kumar MV, Vignesh Kamath, Mahantesh Bembalgi, Namratha Nayak, and Praveen Jodalli. "Osseointegrative and antimicrobial properties of graphene oxide nano coated dental implants: A systematic review." F1000Research 13 (April 17, 2024): 281. http://dx.doi.org/10.12688/f1000research.148180.1.

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Introduction Osseointegration stands as a pivotal concept within the realm of dental implants, signifying the intricate process through which a dental implant integrates with the adjoining bone tissue. Graphene oxide (GO) has been shown to promote osseointegration, the process by which the implant fuses with the surrounding bone. The objective of this study was to assess the osseointegrative and antimicrobial properties of GO nano coated dental implants. Methods A systematic search was conducted using electronic databases (e.g., PubMed, Scopus, Web of Science) to identify relevant studies publ

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Blanc-Sylvestre, Nicolas, Philippe Bouchard, Catherine Chaussain, and Claire Bardet. "Pre-Clinical Models in Implant Dentistry: Past, Present, Future." Biomedicines 9, no. 11 (2021): 1538. http://dx.doi.org/10.3390/biomedicines9111538.

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Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be u

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Tan, Sze Jun, Badiah Baharin, Nurulhuda Mohd, and Syed Nabil. "Effect of Anti-Diabetic Medications on Dental Implants: A Scoping Review of Animal Studies and Their Relevance to Humans." Pharmaceuticals 15, no. 12 (2022): 1518. http://dx.doi.org/10.3390/ph15121518.

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Animal studies have ascertained that hyperglycemia adversely affects bone metabolism and dental implant osseointegration. However, diabetic patients show low occurrence of unfavorable hard or soft peri-implant tissue changes, differences that are possibly due to treatment with anti-diabetic medications. This scoping review aimed to systematically examine the effects of these drugs on implant outcomes and explore the predictive modality of animal studies for clinical practice according to type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Three electronic databases (MEDLINE, E

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López-Valverde, Nansi, Beatriz Pardal-Peláez, Antonio López-Valverde, and Juan Manuel Ramírez. "Role of Melatonin in Bone Remodeling around Titanium Dental Implants: Meta-Analysis." Coatings 11, no. 3 (2021): 271. http://dx.doi.org/10.3390/coatings11030271.

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The theory, known as the “brain-bone axis” theory, involves the central nervous system in bone remodeling. The alteration of the nervous system could lead to abnormal bone remodeling. Melatonin produced by the pineal gland is a hormone that is characterized by its antioxidant properties. The aim of this meta-analysis was to examine the role of melatonin in the growth of new bone around titanium dental implants in vivo. A manual search of the PubMed and Web of Science databases was conducted to identify scientific studies published until November 2020. We included randomized clinical trials (RC

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Ihde, Stefan, and Łukasz Pałka. "Customer Complaints as an Evaluation Tool Assessing the Performance and Clinical Suitability of Different Implant Design." Applied Sciences 12, no. 22 (2022): 11394. http://dx.doi.org/10.3390/app122211394.

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During an assessment of dental implant design effectiveness, most of the data are acquired from clinical or animal studies performed by researchers and clinicians. In order to represent scientific significance, those studies have to be properly designed, focusing on a precisely chosen aspect with inclusion and exclusion criteria. The last of these, especially, can create major limitations for the data collection. In order to create a reliable, complete overview of different implant suitability, the data from a single customer can also be a valuable input in dental science. The aim of the study

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Jamal Sayed, Arshad. "Osseo-densification for preservation and compaction of alveolar bone in enhancing stability of dental implants: A systematic review." Journal of Medical pharmaceutical and allied sciences 13, no. 1 (2024): 6337–53. http://dx.doi.org/10.55522/jmpas.v13i1.5741.

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A higher implant failure rate may be associated with a lack of primary stability. Primary stability is a stationary, entirely mechanical parameter that determines when an implant is placed. Several methods have been developed to improve the primary implant's level of stability. However, Osseo-densification (OD) is a revolutionary implant preparation approach that addresses these issues and enhances the main stability of implants inserted into low-density bones. In light of this, the present systematic review was conducted to understand the Osseo-densification for preservation and compaction of

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Sadowsky, Steven J. "Zirconia Implants: A Mapping Review." Oral 4, no. 1 (2023): 9–22. http://dx.doi.org/10.3390/oral4010002.

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The advent of zirconia ceramics with excellent mechanical, biomechanical, and optical properties has made them attractive metal-free substitutes for titanium implants. Both animal and human studies have documented shortcomings with titanium implants. A mapping review of the current literature on three iterations of zirconia implant designs has been challenging due to heterogeneous success data and limited follow-up. Zirconia implants hold promise for a new generation of dental implants, but technical developments are needed for design and material enhancements that will need to be validated by

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Dantas, Telma, Sara Madeira, Michael Gasik, Paula Vaz, and Filipe Silva. "Customized Root-Analogue Implants: A Review on Outcomes from Clinical Trials and Case Reports." Materials 14, no. 9 (2021): 2296. http://dx.doi.org/10.3390/ma14092296.

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(1) It is estimated that 10% of the world’s population will need a dental implant in their lifetime. Despite all the advances in the comprehension of dental implant designs, materials and techniques, traditional implants still have many limitations. Customized root-analogue implants are, therefore, gaining increased interest in dental rehabilitation and are expected to not only preserve more hard and soft tissues but also avoid a second surgery and improve patient overall satisfaction. In this sense, the aim of this review was to collect and analyse the clinical trials and case reports on cust

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Hakim, Lotfollah Kamali, Tayebeh Ghasemi, Saeed Bashar, and Dorara Dortaj. "The Possible Role of Vitamin D Deficiency in Early Implant Failure." BioMed Research International 2021 (April 6, 2021): 1–7. http://dx.doi.org/10.1155/2021/6639523.

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Background. Dental implants are one of the most successful treatments for restoring tooth function and beauty. Identifying the causes of dental implant failure is useful and vital. This review was aimed at studying the possible role of vitamin D in early implant failure. Method and Material. This review was designed based on the PRISMA guideline. Data was collected using keywords including implant, vitamin D, deficiency, failure, dental, OR tooth in international databases including PubMed, Scopus, Web of Science, Cochrane, and Embase, until 2020. Based on the inclusion and exclusion criteria,

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Scarano, Antonio, Tiziana Orsini, Fabio Di Carlo, Luca Valbonetti, and Felice Lorusso. "Graphene-Doped Poly (Methyl-Methacrylate) (Pmma) Implants: A Micro-CT and Histomorphometrical Study in Rabbits." International Journal of Molecular Sciences 22, no. 3 (2021): 1441. http://dx.doi.org/10.3390/ijms22031441.

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Background—the graphene-doping procedure represents a useful procedure to improve the mechanical, physical and biological response of several Polymethyl methacrylate (PMMA)-derived polymers and biomaterials for dental applications. The aim of this study was to evaluate osseointegration of Graphene doped Poly(methyl methacrylate) (GD-PMMA) compared with PMMA as potential materials for dental implant devices. Methods—eighteen adult New Zealand white male rabbits with a mean weight of approx. 3000 g were used in this research. A total of eighteen implants of 3.5 mm diameter and 11 mm length in GD

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TORCATO, Leonardo Bueno, Paulo Renato Junqueira ZUIM, Daniela Atili BRANDINI, and Rosse Mary FALCÓN-ANTENUCCI. "Relation between bruxism and dental implants." RGO - Revista Gaúcha de Odontologia 62, no. 4 (2014): 371–76. http://dx.doi.org/10.1590/1981-8637201400040000032658.

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OBJECTIVE: The aim of this study was to gather information and discuss the predictability of implant-supported prostheses in patients with bruxism by performing a literature review. METHODS: In order to select the studies included in this review, a detailed search was performed in PubMed and Medline databases, using the following key words: bruxism, dental implants, implant supported prosthesis, and dental restoration failure. Items that were included are: case reports, randomized controlled trials, in vitro studies, literature and systematic reviews, with or without meta-analysis, of the last

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Varoni, Elena, Elena Canciani, Barbara Palazzo, et al. "Effect of Poly-L-Lysine coating on titanium osseointegration: from characterization to in vivo studies." Journal of Oral Implantology 41, no. 6 (2015): 626–31. http://dx.doi.org/10.1563/aaid-joi-d-13-00036.

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Dental implant prostheses cannot preclude a correct and stable implant osseointegration, which is still a challenge and greatly depends on biomaterial-cell interface. Titanium (Ti) coating using polyelectrolyte poly-L-lysine (PLL) may represent an interesting and simple approach, to provide a charged surface net able to improve cell adherence. However, in vitro and in vivo effects of Ti coated with PLL have been poorly investigated. The aims of the present study are (1) to obtain and characterize, chemically and physically, Ti disks coated with PLL (TiPLL); (2) to perform in vitro studies on o

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Aragoneses, Javier, Nansi Lopez Valverde, Manuel Fernandez-Dominguez, et al. "Relevant Aspects of Titanium and Zirconia Dental Implants for Their Fatigue and Osseointegration Behaviors." Materials 15, no. 11 (2022): 4036. http://dx.doi.org/10.3390/ma15114036.

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Osseointegration capacity and good mechanical behavior are key to the success of the dental implant. In many investigations, comparisons of properties are made using different dental implant designs and therefore the results can be influenced by the macrodesign of the dental implant. In this work, studies were carried out with the same dental implant model using different roughness and different materials—commercially pure titanium (grade 4) and zirconia. For this purpose, 80 smooth passivated titanium (Ti), 80 smooth zirconia (ZrO2), and 80 rough passivated titanium (Ti-R) dental implants wer

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Aragoneses, Javier, Nansi Lopez Valverde, Manuel Fernandez-Dominguez, et al. "Relevant Aspects of Titanium and Zirconia Dental Implants for Their Fatigue and Osseointegration Behaviors." Materials 15, no. 11 (2022): 4036. http://dx.doi.org/10.3390/ma15114036.

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Osseointegration capacity and good mechanical behavior are key to the success of the dental implant. In many investigations, comparisons of properties are made using different dental implant designs and therefore the results can be influenced by the macrodesign of the dental implant. In this work, studies were carried out with the same dental implant model using different roughness and different materials—commercially pure titanium (grade 4) and zirconia. For this purpose, 80 smooth passivated titanium (Ti), 80 smooth zirconia (ZrO2), and 80 rough passivated titanium (Ti-R) dental implants wer

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Rubnikovich, S. P., I. S. Khomich, and Yu L. Denisova. "Morphological changes in the bone tissue around dental implants after low-frequency low-intensity ultrasound applications." Proceedings of the National Academy of Sciences of Belarus, Medical series 17, no. 1 (2020): 20–27. http://dx.doi.org/10.29235/1814-6023-2020-17-1-20-27.

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The article presents the results of a histological study of morphological changes in bone tissue around established dental implants after exposure to low-intensity, low-frequency ultrasound during dental implantation. Histological studies of tibia bone blocks were conducted in three groups of laboratory animals around installed dental implants, which were subjected to different modes of ultrasonic exposure. In the course of studies, it was found that the processes of osseointegration of dental implants in animals of all groups occurred without staging. In the early stages, granulation tissue w

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Temiz, Mustafa, Ertunc Dayi, and Nesrin Saruhan. "Evaluation of Blood Titanium Levels and Total Bone Contact Area of Dental Implants." BioMed Research International 2018 (June 26, 2018): 1–7. http://dx.doi.org/10.1155/2018/4121639.

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The purpose of this study was to evaluate the effect of total implant-bone surface contact area of dental implants applied on partial or total edentulous patients on the increase in the level of blood titanium level. Changes of the blood titanium levels were evaluated after placement of the dental implants in 30 patients including 15 females and 15 males. Patients were divided into 3 groups as dental implants were applied on only maxilla, only mandible, or both of them. Taking into the consideration anatomic formation and prosthetic indication, dental implant-bone total contact area was calcul

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Tsikouris, Theodoros P. "The role of bisphosphonates in success and survival of dental implants - effects in osseointegration." Journal of Research and Practice on the Musculoskeletal System 4, no. 4 (2020): 125–29. http://dx.doi.org/10.22540/jrpms-04-125.

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The purpose of this study was to research published studies concerning the effect of bisphosphonates in the success and survival of dental implants. An electronic PubMed search was conducted and we have included clinical trials as well as reviews which include human and animal studies. The most common complication in the published literature for bisphosphonates and dental implants was found to be osteonecrosis of the jaw. As a result, we focused in non-osteonecrosis studies. The results of our review are mixed and there is lack of consensus concerning potential beneficial or detrimental effect

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Siddiqi, A., W. J. Duncan, R. K. De Silva, and S. Zafar. "One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study." BioMed Research International 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/6792972.

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Reports have documented titanium (Ti) hypersensitivity after dental implant treatment. Alternative materials have been suggested including zirconia (Zr) ceramics, which have shown predictable osseointegration in animal studies and appear free of immune responses. The aim of the research was to investigate the bone-to-implant contact (BIC) of one-piece Zr, compared with one-piece Ti implants, placed in the jaws and femurs of domestic sheep. Ten New Zealand mixed breed sheep were used. A One-piece prototype Ti (control) and one Zr (test) implant were placed in the mandible, and one of each impla

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Hasani-Sadrabadi, M. M., S. Pouraghaei, E. Zahedi, et al. "Antibacterial and Osteoinductive Implant Surface Using Layer-by-Layer Assembly." Journal of Dental Research 100, no. 10 (2021): 1161–68. http://dx.doi.org/10.1177/00220345211029185.

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Osseointegration of dental, craniofacial, and orthopedic implants is critical for their long-term success. Multifunctional surface treatment of implants was found to significantly improve cell adhesion and induce osteogenic differentiation of dental-derived stem cells in vitro. Moreover, local and sustained release of antibiotics via nanolayers from the surface of implants can present unparalleled therapeutic benefits in implant dentistry. Here, we present a layer-by-layer surface treatment of titanium implants capable of incorporating BMP-2–mimicking short peptides and gentamicin to improve t

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González-Valls, Georgina, Elisabet Roca-Millan, Juan Manuel Céspedes-Sánchez, Beatriz González-Navarro, Aina Torrejon-Moya, and José López-López. "Narrow Diameter Dental Implants as an Alternative Treatment for Atrophic Alveolar Ridges. Systematic Review and Meta-Analysis." Materials 14, no. 12 (2021): 3234. http://dx.doi.org/10.3390/ma14123234.

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To determine the marginal bone loss and the survival, success and failure rates of narrow dental implants, a systematic literature search was carried out in the MEDLINE (Pubmed), Cochrane, Scopus, and Scielo databases for articles published between 2010 and 2021. The exclusion criteria were: systematic reviews, case reports, expert opinions; animal studies; samples of less than 10 subjects; follow-up periods of less than 36 months; smokers of minimum 10 cigarettes/day; and articles about mini-implants for orthodontic anchorage. Meta-analyses were performed to assess marginal bone loss and impl

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Cruz, Ronaldo Silva, Cleidiel Aparecido Araujo Lemos, Hiskell Francine Fernandes Oliveira, Victor Eduardo de Souza Batista, Eduardo Piza Pellizzer, and Fellippo Ramos Verri. "Comparison of the Use of Titanium–Zirconium Alloy and Titanium Alloy in Dental Implants: A Systematic Review and Meta-Analysis." Journal of Oral Implantology 44, no. 4 (2018): 305–12. http://dx.doi.org/10.1563/aaid-joi-d-17-00233.

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The aim of this study was to compare the values of bone-implant contact (BIC) and removal torque (RTQ) reported in different animal studies for titanium–zirconium (TiZr) and titanium (Ti) dental implants. This review has been registered at PROSPERO under number CRD42016047745. We undertook an electronic search for data published up until November 2017 using the PubMed/Medline, Embase, and The Cochrane Library databases. Eligibility criteria included in vivo studies, comparisons between Ti and TiZr implants in the same study, and studies published in English that evaluated BIC and RTQ. After in

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Debajyoti, Datta, Nandi Ranjita, Goel Preeti, Das Samiran, Majumdar Sayan, and Roy Shubhabrata. "Ultraviolet photofunctionalization: A review." Journal of Orofacial Rehabilitation 4, no. 1 (2024): 17–21. https://doi.org/10.5281/zenodo.11045896.

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<strong>Abstract</strong> <strong>Objective</strong>: Greater biologic capabilities in implant surfaces are required to address the challenges and rising expectations in implant therapy. <strong>Background:</strong> The results of current in vitro and in vivo investigations on titanium's ultraviolet (UV) photofunctionalization are compiled in this article. <strong>Method:</strong> The term "UV photofunctionalization" describes a comprehensive phenomenon of surface alteration of titanium after exposure to UV light, encompassing modifications to physicochemical properties and enhancements to bio

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Gomes, Francisco Isaac Fernandes, Maria Gerusa Brito Aragão, Vicente de Paulo Teixeira Pinto, et al. "Effects of Nonsteroidal Anti-inflammatory Drugs on Osseointegration: A Review." Journal of Oral Implantology 41, no. 2 (2015): 219–30. http://dx.doi.org/10.1563/aaid-joi-d-13-00125.

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The purpose of this study was to review the effects of nonsteroidal anti-inflammatory drugs on osseointegration and determine whether they cause failures in dental implants and whether patients who use them chronically can receive dental implants safely. A bibliographic electronic search was performed using the Cochrane Library, PubMed, and Medline databases, selecting articles published between January 1982 and December 2012. The search included the following keywords, either alone or combined: “nonsteroidal anti-inflammatory drugs,” “dental implants,” “bone healing,” and “osteoprogenitor cel

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López-Valverde, Nansi, Bruno Macedo-de-Sousa, Antonio López-Valverde, and Juan Manuel Ramírez. "Effectiveness of Antibacterial Surfaces in Osseointegration of Titanium Dental Implants: A Systematic Review." Antibiotics 10, no. 4 (2021): 360. http://dx.doi.org/10.3390/antibiotics10040360.

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Titanium (Ti) dental implant failure as a result of infection has been established at 40%, being regarded as one of the most habitual and untreatable problems. Current research is focused on the design of new surfaces that can generate long-lasting, infection-free osseointegration. The purpose of our study was to assess studies on Ti implants coated with different antibacterial surfaces, assessing their osseointegration. The PubMed, Web of Science and Scopus databases were electronically searched for in vivo studies up to December 2020, selecting six studies that met the inclusion criteria. Th

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Krautwald, Lisa, Ralf Smeets, Carolin Stolzer, et al. "Osseointegration of Zirconia Implants after UV-Light or Cold Atmospheric Plasma Surface Treatment In Vivo." Materials 15, no. 2 (2022): 496. http://dx.doi.org/10.3390/ma15020496.

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The influence of UV light and non-thermal plasma on the osseointegration of yttria-stabilized zirconia implants (Y-TZP) comparing the two methods is unclear. The aim of this study was to show the influence of these methods on the osseointegration of dental zirconia implants in an animal model. A total of 54 implants were either untreated, treated with UV light (UV), or non-thermal oxygen plasma for 12 min and inserted into the parietal bones of six domestic pigs. The animals were sacrificed after a healing interval of two, four, and nine weeks. The degree of osseointegration was determined usi

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Anesi, Alexandre, Mattia Di Bartolomeo, Arrigo Pellacani, et al. "Bone Healing Evaluation Following Different Osteotomic Techniques in Animal Models: A Suitable Method for Clinical Insights." Applied Sciences 10, no. 20 (2020): 7165. http://dx.doi.org/10.3390/app10207165.

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Osteotomy is a common step in oncological, reconstructive, and trauma surgery. Drilling and elevated temperature during osteotomy produce thermal osteonecrosis. Heat and associated mechanical damage during osteotomy can impair bone healing, with consequent failure of fracture fixation or dental implants. Several ex vivo studies on animal bone were recently focused on heating production during osteotomy with conventional drill and piezoelectric devices, particularly in endosseous dental implant sites. The current literature on bone drilling and osteotomic surface analysis is here reviewed and t

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Anjum, Shamaa, and Arvina Rajasekar. "Surface Modification of Dental Implants - A Review." Journal of Evolution of Medical and Dental Sciences 10, no. 17 (2021): 1246–50. http://dx.doi.org/10.14260/jemds/2021/265.

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The use of dental implants for the replacement of missing teeth has increased in the last 30 years. The success rates for implant placement depend on a series of both biological and clinical steps which starts with primary stability that is being provided by the amount, quality and the distribution of bone within the proposed implant site. The most important factor in implant osseointegration is surface roughness, which shows increased osteoblast activity at 1 to 100 μm of the surface roughness when compared to a smooth surface. Rough surfaces have excellent osseointegration than smooth surfac

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Najeeb, Shariq, Zohaib Khurshid, Jukka Pekka Matinlinna, Fahad Siddiqui, Mohammad Zakaria Nassani, and Kusai Baroudi. "Nanomodified Peek Dental Implants: Bioactive Composites and Surface Modification—A Review." International Journal of Dentistry 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/381759.

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Purpose. The aim of this review is to summarize and evaluate the relevant literature regarding the different ways how polyetheretherketone (PEEK) can be modified to overcome its limited bioactivity, and thereby making it suitable as a dental implant material.Study Selection. An electronic literature search was conducted via the PubMed and Google Scholar databases using the keywords “PEEK dental implants,” “nano,” “osseointegration,” “surface treatment,” and “modification.” A total of 16in vivoandin vitrostudies were found suitable to be included in this review.Results. There are many viable me

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Steflik, D. E., M. J. Song, A. L. Sjsk, et al. "HVEM studies of the calcified bone interface with endosteal dental implants." Proceedings, annual meeting, Electron Microscopy Society of America 49 (August 1991): 36–37. http://dx.doi.org/10.1017/s042482010008448x.

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Previous studies have suggested the prerequisite of bone interfacing successful endosteal dental implants. This is the concept of osseointegration of dental implants within the jaw. However, the ultrastructure of the actual bone interface is largely unknown. This current study is planned to elucidate with correlative high-voltage electron microscopy (HVEM) and conventional electron microscopy (TEM), the morphology of the interface of the support tissues to endosteal dental implants. All ultrastructural protocols involve undecalcified tissue sectioning.After 2 months healing following extractio

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Aramburú, Jaime Sarda, Sergio Alexandre Gehrke, Berenice Anina Dedavid, Tiago Luis Eilers Treichel, and Ney Luis Pippi. "Correlation of Fracture Resistance of Dental Implants and Bite Force in Dogs described in the literature: An In Vitro Study." Journal of Veterinary Dentistry 38, no. 2 (2021): 75–80. http://dx.doi.org/10.1177/08987564211044940.

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Dental implants are not routinely used for rehabilitation in veterinary dentistry. For some veterinarians, further studies are necessary to be considered for clinical use in animals. The objective of the present in vitro study was to evaluate static fatigue of dental implants and to correlate that with the bite strength of dogs described in the literature. Sixty implants and abutments were used with the smallest diameter of each brand of implant utilized in the study. Three groups ( n = 20) were created on the basis of the implant diameter, all with external hex connector: 3.30 mm (group 1), 4

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Jang, Min-Ho, Young-Bum Park, Jae-Sung Kwon, Yeun-Ju Kim, and Jae-Hoon Lee. "Osseointegration of Plasma Jet Treated Titanium Implant Surface in an Animal Model." Materials 14, no. 8 (2021): 1942. http://dx.doi.org/10.3390/ma14081942.

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Osseointegration of titanium implant is important for the success of both dental and medical implants. Previous studies have attempted to improve osseointegration by considering the use of plasma jet technology, where information with animal models and parameters related to osseointegration is still lacking. Therefore, this study investigated the effects of non-thermal atmospheric pressure plasma jet (NTAPPJ) treatment on titanium implants in terms of osseointegration in mongrel dogs. A total of 41 implants; 21 NTAPPJ treated and 20 control, were placed in the maxilla and mandible of six mongr

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Bacci, Christian, Claudia Schiazzano, Ezio Zanon, Edoardo Stellini, and Luca Sbricoli. "Bleeding Disorders and Dental Implants: Review and Clinical Indications." Journal of Clinical Medicine 12, no. 14 (2023): 4757. http://dx.doi.org/10.3390/jcm12144757.

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Background: Bleeding disorders can be divided into three categories: congenital coagulation disorders (CCDs), antiplatelet-induced bleeding disorders (APBDs) and anticoagulant-induced bleeding disorders (ACBDs). Implant placement can be challenging in these kinds of patients. The aim of this study is to provide evidence on implant surgery in patients with bleeding disorders and to generate some practical recommendations for clinicians. Material and Methods: Pubmed/MEDLINE, Scopus, Web of Science and Cochrane Library databases were screened. The latest search was performed in July 2022. Case re

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Rubnikovich, S. P., and I. S. Khomich. "Evaluation of histological changes in peri-implant bone tissue after ultrasound application at early healing stages." Stomatologist. Minsk, no. 3(30) (September 2018): 38–42. http://dx.doi.org/10.32993/stomatologist.2018.3(30).1.

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The aim was to study the nature of the morphological changes over time in the bone tissue around the implants under the influence of low-intensity pulsed ultrasound in the experiment. Materials and methods. Experimental studies were carried out on rabbits of the chinchilla breed, with dental implants installed in the tibia – two experimental groups with ultrasound and one control group. The animals were withdrawn from the experiment at 1, 2, 4 and 8 weeks and histological examination of the sections of peri-implant tissues was carried out. Results. The processes of osseointegration of dental i

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Kalburgi, Veena, and Surabhi Amborkar. "Comprehensive Approaches to Managing Ridge Atrophy with Basal Implants: A Systematic Review." Journal of Head & Neck Physicians and Surgeons 13, no. 1 (2025): 41–49. https://doi.org/10.4103/jhnps.jhnps_135_24.

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ABSTRACT Introduction: Dental implants are a transformative solution for tooth loss, with basal implantology providing a reliable alternative for patients with severe bone resorption or poor bone quality. Unlike conventional implants, basal implants anchor in dense cortical bone, enabling immediate functionality and eliminating the need for invasive procedures such as grafting or sinus lifts. Materials and Methods: A systematic review following PRISMA and Cochrane Collaboration guidelines was conducted to evaluate the clinical effectiveness and patient satisfaction associated with basal implan

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Rajaraman, Vaishnavi, Deepak Nallaswamy, Dhanraj M. Ganapathy, and Saloni Kachhara. "Osseointegration of Hafnium when Compared to Titanium - A Structured Review." Open Dentistry Journal 15, no. 1 (2021): 137–44. http://dx.doi.org/10.2174/1874210602115010137.

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Aim: This systematic review was conducted to analyse osseointegration of hafnium over conventional titanium. Materials and Methods: Search methodology was comprehended using PICO analysis and a comprehensive search was initiated in PubMed Central, Medline, Cochrane, Ovid, Science Direct, Copernicus and Google Scholar databases to identify the related literature. Randomised control trials, clinical studies, case control studies and animal studies were searched for osseointegration of hafnium coated titanium implants versus conventional titanium implants. Timeline was set to include all the manu

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Labidi, Amel, Sana Bekri, Lamia Mansour, and Sonia Ghoul-Mazgar. "Implants Placement in Contact with Dental Tissue: A Potential Paradigm Shift? Systematic Literature Review." European Journal of Dentistry 13, no. 04 (2019): 642–48. http://dx.doi.org/10.1055/s-0039-1697213.

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AbstractThe aim of this study was to explore the literature for clinical and histological data of an unconventional treatment with implants placement in contact with dental tissue (IPICDT) and to try to clarify its indications and surgical procedure particularities.Relevant publications published until May 2019 on the IPICDT were thoroughly reviewed. Search strategy was developed using a controlled vocabulary combination.Medline’s exploration and manual research identified 397 articles; 15 of these were selected after screening. IPICDT was indicated in three clinical situations: impacted teeth

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