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Journal articles on the topic 'Ann Lauterbach'

Author: Grafiati

Published: 11 December 2022

Last updated: 25 January 2023

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1

Hand, Dominic. "‘The whole fragment’: Fragments and ethics in the poetry of Ann Lauterbach." Frontiers of Narrative Studies 8, no. 1 (July 1, 2022): 51–77. http://dx.doi.org/10.1515/fns-2022-2014.

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Abstract This essay reads the poetry of Ann Lauterbach, from the 1990 s to the present day, tracing the development of her central poetic concept of ‘the whole fragment’. Via close readings of exemplary works, the analysis is supported by her theoretical writings, essays and correspondence, and by archival material. The essay evidences ‘the whole fragment’ as a poetic methodology focused on flaws, ruptures, and transformations. It considers how loss and otherness catalyse the aporetic proclivity of Lauterbach’s poetry in the 1990 s, and analyses emergent formal ‘constellations’ and ‘reels’ as manifestations of ‘the whole fragment’. It then isolates an ethical turn for ‘the whole fragment’ in her poetry of the 2000 s, and traces its renewal through her most recent publications, up to 2018. Following this, it makes several critical postulations. Referencing concepts from Maurice Blanchot and Emmanuel Levinas, it analyses Lauterbach’s responses to 9/11 and the Other, and evaluates her ethical poetry of ‘disaster’. The essay’s conclusion distinguishes Lauterbach’s developments from contemporary practices of the ‘open’ text or ‘poethics’, in order to demonstrate the integrity, importance, and distinctiveness of her œuvre in contemporary American poetry.

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2

Ferguson, Scott. "Ann Lauterbach: An Advance." Iowa Review 18, no. 3 (October 1988): 157–62. http://dx.doi.org/10.17077/0021-065x.3684.

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3

Haas-Lauterbach, Sigrid, Ulrike Immer, Mareike Richter, and Peter Koehler. "Gluten Fragment Detection with a Competitive ELISA." Journal of AOAC INTERNATIONAL 95, no. 2 (March 1, 2012): 377–81. http://dx.doi.org/10.5740/jaoacint.sge_haas-lauterbach.

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Abstract The second generation of a competitive ELISA for prolamin quantification based on the R5 antibody was studied for method performance and suitability to detect partially hydrolyzed prolamins in food. To be able to convert signal intensities to gluten concentrations, as required by the Codex Alimentarius Standard, a new calibrator consisting of a peptic-tryptic digest of wheat, rye, and barley prolamins was used for the first time. LOD and LOQ of the assay were 1.36 and 5.0 mg prolamin/kg food, respectively. Analysis of beer samples and a hydrolyzed wheat product showed that the assay provided significantly higher prolamin concentrations, compared to the sandwich ELISA based on the same antibody, which is only suitable for the detection of intact prolamins. Spiking experiments with defined concentrations of partially hydrolyzed prolamins gave recoveries ranging from 92 to 136%.

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4

Anonymous. "Edward C. Lauterbach, MD." Psychiatric Annals 32, no. 2 (February 2002): 91. http://dx.doi.org/10.3928/0048-5713-20020201-04.

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5

Rosenbrock, Rolf. "Laudatio für Prof. Karl Lauterbach Sc.D. anlässlich der Verleihung der Salomon Neumann Medaille der DGSMP." Das Gesundheitswesen 83, no. 03 (March 2021): 156–58. http://dx.doi.org/10.1055/a-1372-6382.

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ZusammenfassungDer Beitrag enthält die Laudatio anlässlich der Verleihung der Salomon-Neumann-Medaille 2020 der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP) an Prof. Karl Lauterbach.

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6

ZHANG, LIANG, and LI-BING ZHANG. "Leptochilus sarawakensis nom. nov. (Polypodiaceae) from Malaysia." Phytotaxa 379, no. 3 (November 29, 2018): 269. http://dx.doi.org/10.11646/phytotaxa.379.3.6.

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Recent molecular work has found that the fern genera Colysis C. Presl (1849: 146), Kontumia S.K. Wu & K.L. Phan (2005: 245), and Paraleptochilus Copeland (1947: 198) should be subsumed under Leptochilus Kaulfuss (1824: 147) (Dong et al. 2008, Kreier et al. 2008, Kim et al. 2012, Zhang et al. in press) so that Leptochilus can be maintained as monophyletic. The newly defined Leptochilus is then characterized by having an epiphytic habit, simple sterile leaves (except in Kontumia), and much contracted fertile leaves fully covered (except in Kontumia) with sori (acrostichoid sori). Following the results of a new molecular phylogeny (Zhang et al. in press) and morphological study nine new combinations in Leptochilus were made recently (Zhang et al. 2018) including L. fluviatilis (Lauterbach 1910: 507) Liang Zhang & Li Bing Zhang in Zhang et al. (2018: 173). However, the epithet “fluviatilis” is not available when Polypodium fluviatile Lauterbach in Winkler (1910: 507) is transferred to Leptochilus. Here we provide a new name for Polypodium fluviatile in Leptochilus.

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7

Hommel, Thomas. "Lauterbach: Startschuss für eRezept noch in diesem Jahr." DNP - Der Neurologe & Psychiater 23, no. 3 (June 2022): 66. http://dx.doi.org/10.1007/s15202-022-4906-8.

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8

Hommel, Thomas. "Lauterbach: Startschuss für eRezept noch in diesem Jahr." InFo Hämatologie + Onkologie 25, no. 6 (June 2022): 54. http://dx.doi.org/10.1007/s15004-022-9094-3.

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9

Coburn, Kerry L., Edward C. Lauterbach, Nash N. Boutros, Kevin J. Black, David B. Arciniegas, and C. Edward Coffey. "Drs. Coburn, Lauterbach, Boutros, Black, Arciniegas, and Coffey Reply." Journal of Neuropsychiatry and Clinical Neurosciences 22, no. 1 (January 2010): 123.e4. http://dx.doi.org/10.1176/jnp.2010.22.1.123.e4.

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10

Leimkugel, Frank. "Rezension: Christian Wilhelm Trommsdorff (1811-1884) von R. Lauterbach." Berichte zur Wissenschafts-Geschichte 25, no. 1 (March 2002): 39. http://dx.doi.org/10.1002/1522-2365(200203)25:1<39::aid-bewi39>3.0.co;2-2.

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11

Greene, Sandra E. "Christianity, Wealth, and Spiritual Power in Ghana by Karen Lauterbach." Ghana Studies 21, no. 1 (2018): 167–68. http://dx.doi.org/10.1353/ghs.2018.0015.

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12

González, Jorge M., and Paweł J. Domagała. "Castniidae of the Museum of Natural History of the University of Wrocław: new findings from Friedrich Wilhelm Niepelt’s collection with comments on Karl Adolf Georg Lauterbach and August Weberbauer." Nota Lepidopterologica 44 (April 23, 2021): 123–32. http://dx.doi.org/10.3897/nl.44.60261.

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Further results of our research into the Giant Butterfly-Moths (Castniidae) of the Museum of Natural History (University of Wrocław) are presented. Castniids of the Niepelt collection had previously been reviewed. However, while curating other sections of the Lepidoptera collection, we discovered 18 misplaced specimens belonging to nine taxa of Castniidae, several of them bearing typical labels by Niepelt. Among them, two are of particular interest, insofar as they are associated with the world-class botanists August Weberbauer (1871–1948) and Karl Adolf Georg Lauterbach (1864–1937).

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13

Feldman, David B. "Posttraumatic stress disorder at the end of life: Extant research and proposed psychosocial treatment approach." Palliative and Supportive Care 9, no. 4 (November 22, 2011): 407–18. http://dx.doi.org/10.1017/s1478951511000435.

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AbstractAccording to some estimates, 84% of people experience a traumatic event during their lives (Vrana & Lauterbach, 1994), and 15% to 24% then develop posttraumatic stress disorder (PTSD). Many carry with them lasting effects of trauma as they age and enter the last phase of life. PTSD manifests in unique ways at the end of life, possibly disrupting factors associated with a positive dying process, including social support, medical communication, life review, and acceptance of death. Terminally ill people with PTSD may suffer more emotional distress, lower quality of life, and poorer medical prognosis than those without PTSD. Unfortunately, healthcare providers may not be trained to address this issue. This article reviews the literature concerning how PTSD may affect the end of life and proposes an intervention model based on a palliative care philosophy.

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14

Engelhardt, Henriette. "Thomas Klein und Wolfgang Lauterbach (Hg.): Nichteheliche Lebensgemeinschaften. Analysen zum Wandel partnerschaftlicher Lebensformen." KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie 52, no. 4 (December 2000): 801–3. http://dx.doi.org/10.1007/s11577-000-0113-8.

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15

Joziasse, Heleen. "Faith in African Lived Christianity. Bridging Anthropological and Theological Perspectives, edited by Karen Lauterbach, Mika Vähäkangas." Exchange 50, no. 3-4 (December 14, 2021): 320–21. http://dx.doi.org/10.1163/1572543x-12341608.

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16

Wild-Wood, Emma. "Karen Lauterbach and Mika Vahangas (eds), Faith in Lived African Christianity: Anthropological and Theological Perspectives." Studies in World Christianity 28, no. 2 (July 2022): 250–51. http://dx.doi.org/10.3366/swc.2022.0395.

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17

Premawardhana, Devaka. "Faith in African Lived Christianity: Bridging Anthropological and Theological Perspectives, written by Lauterbach, Karen, and Mika Vähäkangas." Journal of Religion in Africa 52, no. 1-2 (June 3, 2022): 240–42. http://dx.doi.org/10.1163/15700666-12340229.

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18

Kaunda, Chammah J. "Faith in African Lived Christianity: Bridging Anthropological and Theological Perspectives, edited by Karen Lauterbach and Mika Vähäkangas." Mission Studies 38, no. 2 (September 28, 2021): 305–6. http://dx.doi.org/10.1163/15733831-12341746.

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19

Estrada-Carrasquillo, Wilmer. "Faith in African Lived Christianity: Bridging Anthropological and Theological Perspectives, by Karen Lauterbach and Mika Vähäkangas (eds.)." Pneuma 42, no. 3-4 (December 9, 2020): 564–66. http://dx.doi.org/10.1163/15700747-04203010.

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20

Heintze, Isolde. "Rolf Becker und Wolfgang Lauterbach (Hg.): Bildung als Privileg? Erklärungen und Befunde zu den Ursachen der Bildungsungleichheit." KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie 57, no. 3 (September 2005): 577–79. http://dx.doi.org/10.1007/s11577-005-0202-9.

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21

Süss, H., W. R. Müller-Stoll, and E. Mädel-Angeliewa. "Ein Rosaceen-Holz,Rosoxylon hassiacum sp. nova, gen. nov., aus dem Untermiozän von Lauterbach in Hessen (Deutschland)." Feddes Repertorium 110, no. 3-4 (June 1999): 153–60. http://dx.doi.org/10.1002/fedr.4921100302.

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22

Süss, H., W. R. Müller-Stoll, and E. Mädel-Angeliewa. "Ein Rosaceen-Holz, Rosoxylon hassiacum sp. nova, gen. nov., aus dem Untermiozän von Lauterbach in Hessen (Deutschland)." Feddes Repertorium 110, no. 3-4 (April 18, 2008): 153–60. http://dx.doi.org/10.1002/fedr.19991100302.

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23

Brosziewski, Achim. "Udo Kuckartz, Heiko Grunenberg und Andreas Lauterbach (Hg.): Qualitative Datenanalyse: computergestützt. Methodische Hintergründe und Beispiele aus der Forschungspraxis." KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie 58, no. 4 (December 2006): 741–42. http://dx.doi.org/10.1007/s11577-006-0279-9.

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24

Arndal, Steffen. "Manfred Engel (Hrsg.), Rilke-Handbuch. Leben ? Werk ? Wirkung. Unter Mitarbeit von Dorothea Lauterbach, Verlag J. B. Metzler, Stuttgart / Weimar 2004." Orbis Litterarum 62, no. 1 (February 2007): 83–88. http://dx.doi.org/10.1111/j.1600-0730.2007.00887.x.

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25

Joyce. "Stones of Law, Bricks of Shame: Narrating Imprisonment in the Victorian Age, edited by Jan Alber and Frank Lauterbach." Victorian Studies 52, no. 4 (2010): 653. http://dx.doi.org/10.2979/vic.2010.52.4.653.

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26

Lauriat, B. "MORTAR OF MORALS: Stones of Law, Bricks of Shame: Narrating Imprisonment in the Victorian Age. Edited by JAN ALBER and FRANK LAUTERBACH." Essays in Criticism 60, no. 4 (October 1, 2010): 361–67. http://dx.doi.org/10.1093/escrit/cgq015.

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27

Belkhiria, A., I. Bemromdhane, F. Medini, S. Elhecmi, and R. Labbene. "Dystonie et trouble bipolaire : quels liens ? À propos d’un cas." European Psychiatry 28, S2 (November 2013): 54–55. http://dx.doi.org/10.1016/j.eurpsy.2013.09.143.

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IntroductionLa dystonie est caractérisée par un trouble du tonus musculaire. Elle constitue un groupe hétérogène de mouvements anormaux dont la physiopathologie est actuellement mal comprise. Quelques études ont par ailleurs suggéré la comorbidité entre dystonie et troubles psychiatriques dont la maladie bipolaire. Nous rapportons le cas d’une patiente illustrant l’association entre les deux troubles. À travers une revue de la littérature, nous rapportons l’état actuel des connaissances sur cette comorbidité. Vignette cliniqueMlle L âgée de 33 ans a développé en 2008, une dystonie du tronc d’aggravation progressive. Le diagnostic de dystonie primitive idiopathique a été retenu et elle a été mise sous Levodopa. Elle a présenté en 2009 un premier accès maniaque probablement déclenché par la Levodopa puis une deuxième rechute maniaque en 2011 faisant porter le diagnostic de trouble bipolaire type I.DiscussionLes premiers cas de trouble bipolaire associé à la dystonie idiopathique ont été rapportés par Lauterbach et al. en 1992. La même équipe a retrouvé une prévalence de trouble bipolaire plus importante chez les patients atteints de dystonie primitive par rapport à des sujets contrôles. Les explications physiopathologiques sont multiples. En effet, quelques études ont montré un lien génétique commun entre les troubles de l’humeur et certaines formes de dystonie. D’autres auteurs ont avancé des hypothèses neurobiologiques impliquant la voie pallido-thalamo-corticale. Enfin, une dysrégulation du système dopaminergique pourrait être à l’origine de cette co-morbidité. ConclusionLes liens existants entre trouble bipolaire et dystonie doivent faire l’objet de plus de recherches, permettant ainsi une meilleure compréhension de la physiopathologie des deux troubles ainsi qu’une meilleure approche des malades.

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28

Nolte, Insa. "Karen Lauterbach, Christianity, Wealth, and Spiritual Power in Ghana. Basingstoke: Palgrave Macmillan (hb £89.99 – 978 3 319 33493 6). 2017, xvii + 221 pp." Africa 88, no. 4 (November 2018): 881–82. http://dx.doi.org/10.1017/s0001972018000542.

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29

Johnson, Frank. "The Chitlin’ Circuit and the Road to Rock & Roll. Preston Lauterbach. New York: W.W. Norton & Co., 2011. 338 pp. $26.95 cloth." Journal of Popular Culture 45, no. 3 (May 30, 2012): 667–69. http://dx.doi.org/10.1111/j.1540-5931.2012.00950_3.x.

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30

George, S. Elizabeth. "Gut reaction. “Intestinal Metabolism of Xenobiotics,” A.Sj. Koster, E. Richter, F. Lauterbach, and F. Hartmann (eds). New York: Gustav Fischer Verlag, 1989, 338 pp, $96.50." Environmental and Molecular Mutagenesis 15, no. 1 (1990): 67. http://dx.doi.org/10.1002/em.2850150109.

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31

Owusu-Ansah, David, and Emmanuel Akyeampong. "Religious Pluralism and Interfaith Coexistence: Ecumenicalism in the Context of Traditional Modes of Tolerance." Legon Journal of the Humanities 30, no. 2 (December 31, 2019): 1–18. http://dx.doi.org/10.4314/ljh.v30i2.1.

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In many parts of the developing world, religion is singled out as the cause for violent clashes. At the 2007 TrustAfrica workshop in Dakar, the conference of religious leaders, scholars, and experts from 12 African countries and the Diaspora explored this concern under the theme "Meeting the Challenges of Religion and Pluralism in Africa." It was observed that religiously justified conflicts were often the repackaging of community concerns regarding issues of social, economic, and political injustices, inequities and exclusions. Consequently, a project on “religious pluralism and interfaith coexistence in Ghana” was funded in 2008 as part of the efforts to examine the role of local traditions as a foundation to interfaith dialogue. Earlier in 2005, a similar project on the theme of Islam and tolerance, with funding from Harvard and Michigan State University, was conducted in Ghana. Several issues emerging from the field conversations are pertinent to topics of how history shaped Muslim relations with their non-Muslim hosts in West Africa. It is often argued in the literature that Islam’s inherently adoptive attitude toward African religious culture made it possible for Muslims and their non-Muslim hosts to co-exist. However, this research contends that, in the case of Ghana, it was the traditional local culture as defined by indigenous religious values that shaped and moderated the environment that sustained peaceful interreligious relations. The authors express concern that as the country experiences rapid urbanization, Westernization, proliferation of charismatic churches and aggressive Christian evangelization, the traditional values that underpinned pluralism and peace in historic times might be threatened (George Bob-Milliar and Karen Lauterback, 2018).

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32

Bridge, Helen. "A Companion to the Works of Rainer Maria Rilke by Erika A. Metzger, Michael M. Metzger, Rainer Maria RilkeRilke-Handbuch: Leben, Werk, Wirkung by Manfred Engel, Dorothea Lauterbach." Modern Language Review 101, no. 2 (2006): 585–87. http://dx.doi.org/10.1353/mlr.2006.0092.

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33

Roccati, G. Matteo. "Pierre Kunstmann, Achim Stein (éd.), Le Nouveau Corpus d’Amsterdam, Actes de l’atelier de Lauterbad, 23-26 février 2006." Studi Francesi, no. 163 (LV | I) (May 1, 2011): 147–48. http://dx.doi.org/10.4000/studifrancesi.5872.

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34

Raguz, Josipa, Theresa Kleissner, Sandra Rosskopf, Mohamed Habbeddine, Katharina Lechner, Valentin Just, Donna Edwards, et al. "Abstract 2048: In vitro and in vivo characterization of non-oncolytic engineered arenavirus vectors for cancer immunotherapy." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2048. http://dx.doi.org/10.1158/1538-7445.am2022-2048.

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Abstract Cytotoxic CD8+ T cells are paramount for effective cancer immunotherapy. We engineered two distantly related arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PICV), encoding the same non-oncogenic HPV16 E7E6 fusion protein to effectively mount and maintain tumor specific CD8+ T cell responses. The designated vectors, HB-201 (LCMV) and HB-202 (PICV), are currently in an ongoing Phase I/II open labelled clinical trial of HB-201 single vector therapy and HB-202/HB-201 alternating two-vector therapy in patients with treatment-refractory HPV16+ cancers (NCT04180215). To characterize the immunogenic properties of both vectors, we designed a comprehensive set of preclinical and translational experiments utilizing human PBMCs, artificial APCs and HPV16 E6 and E7 specific reporter T cells. This was done in conjunction with a preclinical model for HPV16 associated cancer (TC-1). HB-201 (LCMV) and HB-202 (PICV) surrogate vectors encoding GFP readily infected human monocytes, plasmacytoid dendritic, and conventional dendritic cells. In addition, HB-201 and HB-202 vectors successfully induced antigen presentation of E7 and E6 epitopes as evidenced by TCR reporter cells. Innate immune cell activation and cytokine responses to HB-202 were slightly lower compared to HB-201, findings which are consistent with different memory profiles of E7 specific CD8+ T cells in non-tumor bearing mice. In a therapeutic setting of the TC-1 tumor model, both vectors were comparably effective, showing major infiltration of CD8+ T cells into the tumor microenvironment, tumor growth delay and a significantly prolonged survival already after a single administration. In this data set we have confirmed the strong immunogenicity of the engineered arenavirus platform leading to efficient tumor control in a relevant mouse model for HPV16+ cancers, which further supports the clinical development of our novel arenavirus platform. Citation Format: Josipa Raguz, Theresa Kleissner, Sandra Rosskopf, Mohamed Habbeddine, Katharina Lechner, Valentin Just, Donna Edwards, Igor Matushansky, Christoph Lampert, Klaus K. Orlinger, Henning Lauterbach. In vitro and in vivo characterization of non-oncolytic engineered arenavirus vectors for cancer immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2048.

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35

Gupta, M. A., and B. Vujcic. "1078 Sleep Problems In Posttraumatic Stress Disorder (PTSD) In A Nationally Representative Us Sample Before And After Controlling For Comorbid Depression: Results From A Nationally Representative US Sample." Sleep 43, Supplement_1 (April 2020): A410—A411. http://dx.doi.org/10.1093/sleep/zsaa056.1074.

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Abstract Introduction The impact of psychiatric comorbidities on sleep disturbances in PTSD have been studied in the National Comorbidity Survey (NCS)(Leskin GA, 2002) and the NCS-replication (Lauterbach D, 2011) studies. We examined sleep problems in PTSD before and after controlling for comorbid depressive disease, in the National Ambulatory Medical Care Survey(NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS) which use a multi-stage probability design to collect nationally representative data on health care visits. Methods We examined patient visits(1995-2015) from NAMCS/NHAMCS with a PTSD diagnosis (ICD-9-CM 309.81). Both NAMCS/NHAMCS allow ≥3 reasons for visit(RFV) and ≥3 physician-assigned diagnoses (using ICD9-CM codes). The following variables were created: ‘Insomnia’: ICD9-CM codes 307.41,307.42,780.51,RFV 11351; ‘Sleep Disturbance’(SD): ICD-9CM codes 780.5, 780.50, 780.59; ‘Nightmares’: ICD9-CM code 307.4, RFV 11353; Obstructive sleep apnea (OSA): ICD-CM codes 327.23,780.57, RFV 11355, checklist; and ‘Depression’: ICD9-CM codes 296.2, 296.3, 296.82, 311, 296.20-296.36, 300.4. Results There were an estimated 37,262,245±3,203,047 (unweighted count or UWC=3,995; 66.4%±1.8% female;.mean±age: 40.39 ± 0.56 years; ‘Depression’ was comorbid with 37.7%±1.5% cases) PTSD patients visits. All sleep variables accounted for 11.2%±1.2% (UWC=303) of PTSD visits with their individual frequencies as follows: ‘Insomnia’6.5%±1.1%(UWC=153); ‘Nightmares’: 1.9%±0.4%(UWC=74); ‘SD’: 2.0%±0.3%(UWC=67); OSA: 1.3%±0.3%(UWC=27). Logistic regression analysis using PTSD versus all other patient visits as dependent variable revealed the following sleep predictors of PTSD after controlling for age and sex and: (i) before controlling for ‘Depression’: ‘Insomnia’: OR=7.16, (95%CI 4.78-10.73); ‘SD’: OR=4.43(95%CI 2.55-7.71); ‘Nightmares’:OR=104.29 (95%CI56.65-192.02); ‘OSA’: OR=1.71(95%CI 0.94-3.12); and (ii) after controlling for ‘Depression’: ‘Insomnia’: OR=2.88 (95%CI 1.87-4.42); ‘SD’: OR=2.84 (95%CI 1.73-4.67); and ‘Nightmares’: OR=58.33(95%CI 26.39-128.94); and ‘OSA’: OR=2.02(95%CI 1.14-3.57). Conclusion In a nationally representative sample, the association of PTSD with insomnia, sleep disturbance and nightmares remained significant, albeit decreased, after controlling for the confounding effect of comorbid depression; however the association of PTSD with OSA emerged only after the effect of depression was controlled for. Support None

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36

Evdokimova, O. V., V. A. Zhadnov, Oussema Elmi, and A. O. Burshinov. "Psychological and Behavioral Features of Patients with Pharmacoresistant Epilepsy." NAUKA MOLODYKH (Eruditio Juvenium) 10, no. 4 (December 31, 2022): 381–90. http://dx.doi.org/10.23888/hmj2022104381-390.

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INTRODUCTION: Pharmacoresistant epilepsy (PRE) is diagnosed in 30% of all patients with epilepsy, causing disorders in psychological and social well-being, as well as the development of intrapersonal conflicts and psychological defense mechanisms. The psychotraumatic role of the epilepsy diagnosis is deepened by restrictions in the daily and professional activities of patients. AIM: To analyze the psychological and behavioral characteristics of patients with PRE compared with patients with successfully controlled seizures. MATERIALS AND METHODS: We studied 60 patients diagnosed with epilepsy aged 20 to 75 years, who were divided to 2 groups: 30 patients with pharmacoresistant epilepsy and 30 patients with successfully controlled seizures. The following psychometric methods were used in the study: Eysenck's test; Strelau test; Freiburg Multivariate Personality Inventory (FPI); Toronto alexithymic scale; T. Bant's scale of manipulative attitude; test ‘Tendency to self-destruction’; test of intrapersonal conflicts by V. Lauterbach; questionnaire ‘Types of behavior in conflict’ by K. Thomas – R. Kilman. Statistical differences between the groups were assessed using non-parametric statistics; differences were considered significant at p < 0.05. RESULTS: The patients with PRE showed a higher level of anxiety and alexithymia, a lower level of spontaneous and reactive aggression and tranquility compared to the patients of the control group. Patients with PRE show a higher tendency to manipulative behavior and a lower tendency to self-destructive behavior than patients with successful seizure control. The spectrum of intrapersonal conflicts in patients with PRE is represented by an imbalance between the needs for dominance, achievements, independence and passive avoidance, submission, unrealized opportunities. In interpersonal conflicts, these patients are prone to avoidant behavior, while patients in the control group demonstrate the flexibility of behavior using all possible behavioral strategies. In general, patients with PRE have psychological and behavioral characteristics typical of patients with epilepsy, but expressed to a greater extent. However, in patients with PRE, we found a lower level of aggression and a lower tendency to self-destructive behavior than in patients with successfully controlled seizures, which can be explained by the compensating impact of persistent seizures on high aggressiveness, as well as a behavioral strategy that manifests itself in low compliance with a simultaneous tendency to manipulative behavior when interacting with a doctor. CONCLUSION: The conducted study revealed psychological and behavioral features of patients with PRE, causing significant psychological and social maladaptation requiring correction by medical professionals and psychologists. The research of the psychological characteristics of patients with epilepsy seems promising to us for optimizing an individual treatment strategy.

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Edwards, Donna, Michael Schwendinger, Kia Katchar, Katia Schlienger, Klaus Orlinger, Igor Matushansky, and Henning Lauterbach. "Abstract 3284: HB-201 and HB-202, an arenavirus-based immunotherapy, induces tumor T cell infiltration in patients with HNSCC and other HPV16+ tumors." Cancer Research 82, no. 12_Supplement (June 15, 2022): 3284. http://dx.doi.org/10.1158/1538-7445.am2022-3284.

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Abstract Background: Human Papillomavirus 16 (HPV16) is the most common etiologic agent of HPV-associated cancers. Treatment options are limited for patients with HPV16+ recurrent or metastatic cancers. HPV16 E7 and E6 oncogenes constitute attractive immunotherapeutic targets. HB-201 and HB-202 are live-attenuated replicating vectors based on LCMV and PICV arenaviruses, respectively, that express the same non-oncogenic HPV16 E7E6 fusion protein for induction of tumor specific T cell responses. Methods: A Phase I/II open labelled clinical trial of HB-201 single vector therapy and HB-202/HB-201 alternating two-vector therapy in patients with treatment-refractory HPV16+ cancers is currently ongoing (NCT04180215). To assess circulating E6/E7 specific T cell responses, IFN-γ enzyme-linked immunospot (ELISpot) and intracellular cytokine staining were performed on pre- and post-treatment peripheral blood mononuclear cells (PBMCs). Evaluation of T cell infiltration and PD-L1 status in tumor bed was performed on paired tissue biopsies from a subset of patients by multiplex immunofluorescence. Results: Single vector therapy (HB-201) and alternating two-vector therapy (HB-202/HB-201) rapidly induce high E6/E7 specific T cell levels, reaching up to ~40% of the circulating CD8+ T cell pool. Alternating two-vector therapy seems to maintain E6/E7 specific T cell responses better in continuous dosing compared to single vector therapy. Furthermore, we demonstrate tumor tissue T cell infiltration in more than 50% of patient samples analyzed. Currently, in depth sequencing of paired biopsies is underway to characterize the tumor microenvironment in response to HB-201 and HB-202/HB-201 treatment. Conclusion: In this updated dataset, we show that HB-201 and HB-202/HB-201, rapidly induce unprecedented E6/E7 specific T cell levels in circulation following a single dose. Furthermore, these data are seen in conjunction with a pronounced increase of post-treatment CD8+ T cells in tumor, suggesting E6/E7 specific T cell infiltration. Our arenavirus vectors expressing the E7E6 fusion antigen demonstrate an attractive and safe therapy for patients with treatment refractory HPV16+ cancers. The ability of replicating arenavirus vectors to incorporate a broad range of antigens and the potent T cell inducing capacity provide a strong rationale to apply this novel therapy to other cancers. Citation Format: Donna Edwards, Michael Schwendinger, Kia Katchar, Katia Schlienger, Klaus Orlinger, Igor Matushansky, Henning Lauterbach. HB-201 and HB-202, an arenavirus-based immunotherapy, induces tumor T cell infiltration in patients with HNSCC and other HPV16+ tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3284.

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Hinterberger, M., J. Medina-Echeverz, M. Testori, M. Geiger, R. Giessel, B. Bathke, R. Kassub, et al. "P04.02 A novel cancer immunotherapy combines rMVA-CD40L with tumor targeting antibodies." Journal for ImmunoTherapy of Cancer 8, Suppl 2 (October 2020): A37.1—A37. http://dx.doi.org/10.1136/jitc-2020-itoc7.71.

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BackgroundVirus-based vaccines and appropriate costimulation potently enhance antigen-specific T cell immunity against cancer. In the present study, we exploit both innate and adaptive immune responses triggered by a novel recombinant modified vaccinia virus Ankara (rMVA) encoding a Tumor-Associated Antigen (TAA) and the costimulatory CD40L against solid tumors in combination regimes to overcome tumor-induced resistance to immunotherapy.Material and MethodsSubcutaneous murine tumors were induced in C57BL/6 or Balb/c mice using syngeneic tumor cell lines. When tumors were established (60–80 mm3) mice were intravenously injected with rMVA-CD40L. Tumor growth monitoring and immune cell analysis was performed.ResultsTherapeutic treatment with rMVA-CD40L resulted in the control of established tumors in several independent tumor models. This antitumor effect was based on the generation of non-exhausted, systemic tumor-specific cytotoxic CD8+ T cells that was essential for therapeutic efficacy. Strikingly, rMVA-CD40L also induced strong NK cell activation and enhanced cytotoxicity. Moreover, the combination of rMVA-CD40L and tumor targeting antibodies resulted in increased therapeutic antitumor efficacy. This therapeutic combination relied on Fcγ receptor-expressing immune cells as well as on NK cells.ConclusionWe describe a novel and translationally relevant therapeutic synergy between viral vaccination and CD40L costimulation. We show strengthened antitumor immune responses when both rMVA-CD40L-induced innate and adaptive immune mechanisms are exploited by combining immunotherapeutic regimes, such as TAA targeting antibodies. This finding could have a direct positive impact in therapeutic regimens where TAA targeting antibodies could be employed.Disclosure InformationM. Hinterberger: A. Employment (full or part-time); Significant; Bavarian Nordic. J. Medina-Echeverz: A. Employment (full or part-time); Significant; Bavarian Nordic. M. Testori: A. Employment (full or part-time); Significant; Bavarian Nordic. M. Geiger: A. Employment (full or part-time); Significant; Bavarian Nordic. R. Giessel: A. Employment (full or part-time); Significant; Bavarian Nordic. B. Bathke: A. Employment (full or part-time); Significant; Bavarian Nordic. R. Kassub: A. Employment (full or part-time); Significant; Bavarian Nordic. F. Gräbnitz: A. Employment (full or part-time); Significant; Bavarian Nordic. G. Fiore: A. Employment (full or part-time); Significant; Bavarian Nordic. S. Wennier: A. Employment (full or part-time); Significant; Bavarian Nordic. P. Chaplin: A. Employment (full or part-time); Significant; Bavarian Nordic. M. Suter: A. Employment (full or part-time); Significant; Bavarian Nordic. H. Hochrein: A. Employment (full or part-time); Significant; Bavarian Nordic. H. Lauterbach: A. Employment (full or part-time); Significant; Bavarian Nordic.

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Strauss, Judith, Marilies Scheinost, Theresa Kleissner, Diana Reckendorfer, Kimberly Pojar, Mohamed Habbeddine, Sarah Ahmadi-Erber, et al. "Abstract 4198: Evaluation of a cancer immunotherapy with engineered arenavirus vectors and 4-1BB agonists in a preclinical tumor model." Cancer Research 82, no. 12_Supplement (June 15, 2022): 4198. http://dx.doi.org/10.1158/1538-7445.am2022-4198.

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Abstract T cells play a central role in immune responses against cancer. Within the tumor, however, T cells are exposed to a plethora of inactivating factors causing various degrees of dysfunction, changes in metabolism and a generally reduced cellular fitness, eventually leading to tumor progression. To prevent or delay the onset of exhaustion and instead augment effector functions and persistence of functional T cells, costimulatory factors and cytokines are needed. Targeting 4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily, has been shown to represent a promising strategy for inducing an activating signal in CD8+ T cells, resulting in increased pro-inflammatory cytokine secretion, cytotoxic function, and survival. Engineered arenavirus vectors based on lymphocytic choriomeningitis virus (LCMV) or Pichinde virus (PICV) have been shown previously to induce massive infiltration of tumor antigen specific CD8+ T cells into the tumor in several preclinical cancer models. To investigate whether enhanced co-stimulation via 4-1BB further improves T cell responses and/or tumor control, combination therapies with replicating LCMV based vectors (artLCMV) and 4-1BB agonists were explored. A single intravenous treatment of artLCMV encoding the tumor associated antigens (TAA) gp70 or Trp2 in B16.F10 tumor bearing mice induced TAA specific CD8+ T cells in both the periphery and the tumor, resulting in tumor growth delay and some complete responses. Combining artLCMV with agonistic anti-4-1BB significantly improved tumor control and increased the number of complete responders. Analysis of tumor infiltrating lymphocytes revealed higher absolute numbers of TAA specific CD8+ T cells in the combination group compared to the artLCMV alone group. Analyses of the TAA specific cells revealed that more cells expressed granzyme B, Ki67 and Bcl-XL when co-stimulated with anti-4-1BB compared to the group treated with artLCMV alone. Importantly, encoding 4-1BBL in addition to a TAA in artLCMV revealed similar outcomes as just summarized for the combination with agonistic antibodies. Overall, these experiments confirmed the strong antigenicity and T cell inducing capacity of the engineered arenavirus platform, leading to efficient tumor control in a stringent mouse model. Combination with 4-1BB agonists, either in form of antibodies or encoded within the vector genome, was shown to further augment TAA-specific T cell responses within the tumor, leading to better tumor growth control and a higher rate of complete responders. Citation Format: Judith Strauss, Marilies Scheinost, Theresa Kleissner, Diana Reckendorfer, Kimberly Pojar, Mohamed Habbeddine, Sarah Ahmadi-Erber, Daniela Deutschmann, Sarah Schmidt, Josipa Raguz, Igor Matushansky, Christoph Lampert, Klaus K. Orlinger, Henning Lauterbach. Evaluation of a cancer immunotherapy with engineered arenavirus vectors and 4-1BB agonists in a preclinical tumor model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 4198.

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Harvey, Mark S., Andrew D. Austin, and Mark Adams. "The systematics and biology of the spider genus Nephila (Araneae:Nephilidae) in the Australasian region." Invertebrate Systematics 21, no. 5 (2007): 407. http://dx.doi.org/10.1071/is05016.

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Five species of the nephilid genus Nephila Leach are found in the Australasian region, which for the purposes of this study was defined as Australia and its dependencies (including Lord Howe I., Norfolk I., Christmas I., Cocos (Keeling) Is), New Guinea (including Papua New Guinea and the Indonesian province of West Papua), Solomon Is, Vanuatu, New Caledonia, Fiji, Tonga, Niue, New Zealand and other parts of the south-west Pacific region. All species are redescribed and illustrated. Nephila pilipes (Fabricius) occurs in the closed forests of eastern and northern Australia, New Guinea, Solomon Is and Vanuatu (through to South-East Asia); N. plumipes (Latreille) is found in Australia (including Lord Howe I. and Norfolk I.), New Guinea, Vanuatu, Solomon Is and New Caledonia; N. tetragnathoides (Walckenaer) inhabits Fiji, Tonga and Niue; N. antipodiana (Walckenaer) occurs in northern Australia (as well as Christmas I.), New Guinea and Solomon Is (through to South-East Asia); and N. edulis (Labillardière) is found in Australia (including Cocos (Keeling) Is), New Guinea, New Zealand and New Caledonia. Epeira (Nephila) walckenaeri Doleschall, E. (N.) hasseltii Doleschall, N. maculata var. annulipes Thorell, N. maculata jalorensis Simon, N. maculata var. novae-guineae Strand, N. pictithorax Kulczyński, N. maculata var. flavornata Merian, N. pictithorax Kulczyński, N. maculata var. flavornata Merian, N. maculata piscatorum de Vis, and N. (N.) maculata var. lauterbachi Dahl are proposed as new synonyms of N. pilipes. Nephila imperialis var. novaemecklenburgiae Strand, N. ambigua Kulczyński, N. sarasinorum Merian and N. celebesiana Strand are proposed as new synonyms of N. antipodiana. Meta aerea Hogg, N. meridionalis Hogg, N. adelaidensis Hogg and N. meridionalis hermitis Hogg are proposed as new synonyms of N. edulis. Nephila picta Rainbow is removed from the synonymy of N. plumipes and treated as a synonym of N. edulis, and N. nigritarsis insulicola Pocock is removed from the synonymy of N. plumipes and treated as a synonym of N. antipodiana. Allozyme data demonstrate that N. pilipes is distinct at the 80% FD level from N. edulis, N. plumipes and N. tetragnathoides. Nephila plumipes and N. tetragnathoides, deemed to represent sister-taxa owing to the shared presence of a triangular protrusion of the male pedipalpal conductor, were found to differ at 15% FD in the genetic study. No genetic differentiation was found between 10 populations of N. edulis sampled across mainland Australia. Species of the genus Nephila have been extensively used in ecological and behavioural studies, and the biology of Nephila species in the Australasian region is extensively reviewed and compared with studies on Nephila species from other regions of the world.

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"Herbert-Lauterbach-Preis 2009." Zeitschrift für Orthopädie und Unfallchirurgie 147, no. 01 (February 23, 2009): 5. http://dx.doi.org/10.1055/s-0029-1202234.

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"Preisverleihung - Herbert-Lauterbach-Preis 2007." Zeitschrift für Orthopädie und Unfallchirurgie 145, no. 06 (December 21, 2007): 696. http://dx.doi.org/10.1055/s-2007-1019440.

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"Einmal mit dem Gesundheitsminister, Herrn Lauterbach, tauschen!" Endo-Praxis 38, no. 04 (December 2022): 168. http://dx.doi.org/10.1055/a-1776-3407.

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"Duo Plast applies BASF's antistatic additive to stretch film, approved for use in potentially explosive areas." Additives for Polymers 2022, no. 3 (March 1, 2022). http://dx.doi.org/10.12968/s0306-3747(22)70059-0.

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The PE blown film “Duo Ex-Tra”, by film manufacturer Duo Plast AG in Lauterbach, Germany, is equipped with the static dissipative additive Elastostat®. This creates the first stretch film suitable for use in potentially explosive atmospheres. The newly developed film avoids the ignition source electrostatics. This should ensure that stretched pallet units no longer pose an explosion hazard.

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"Bundesgesundheitsminister Prof. Lauterbach ernennt die Beauftragten seines Geschäftsbereichs." GesundheitsRecht 21, no. 2 (February 1, 2022): r12. http://dx.doi.org/10.9785/gesr-2022-210203.

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"Preis der Vereinigung Berufsgenossenschaftlicher Kliniken 2005 (Herbert-Lauterbach-Preis)." Zeitschrift für Orthopädie und ihre Grenzgebiete 144, no. 01 (February 23, 2006): 13. http://dx.doi.org/10.1055/s-2006-933572.

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"Preis der Vereinigung Berufsgenossenschaftlicher Kliniken 2006 (Herbert-Lauterbach-Preis)." Zeitschrift für Orthopädie und ihre Grenzgebiete 144, no. 03 (July 4, 2006): 243. http://dx.doi.org/10.1055/s-2006-947122.

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"Preis der Vereinigung Berufsgenossenschaftlicher Kliniken 2005-03-24 (Herbert-Lauterbach-Preis)." Zeitschrift für Orthopädie und ihre Grenzgebiete 143, no. 02 (April 29, 2005): 137. http://dx.doi.org/10.1055/s-2005-868441.

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Polack, Emmanuelle. "Iris Lauterbach, Der Central Collecting Point in München: Kunstschutz, Restitution, Neubeginn (Veröffentlichun." Perspective, March 17, 2016. http://dx.doi.org/10.4000/perspective.6184.

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"BM Lauterbach stellt Krankenhaus-Kommission vor – Expertinnen und Experten erarbeiten Reform-Empfehlungen." GesundheitsRecht 21, no. 6 (June 1, 2022): r44. http://dx.doi.org/10.9785/gesr-2022-210603.

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