Journal articles on the topic 'Annales maximi'

This article comments on: Marie-Pier Fournier, Maxime C. Paré, Valentina Buttò, Sylvain Delagrange, Jean Lafond and Annie Deslauriers, How plant allometry influences bud phenology and fruit yield in two Vaccinium species, Annals of Botany, Volume 126, Issue 5, 9 October 2020, Pages 825–835, https://doi.org/10.1093/aob/mcaa083

We show a correspondence between a classification of maximal abelian sub-algebras (MASAs) proposed by Jacques Dixmier (Dixmier 1954. Annals of Mathematics59 (2) 279–286) and fragments of linear logic. We expose for this purpose a modified construction of Girard's hyperfinite geometry of interaction (Girard 2011. Theoretical Computer Science412 (20) 1860–1883). The expressivity of the logic soundly interpreted in this model is dependent on properties of a MASA which is a parameter of the interpretation. We also unveil the essential role played by MASAs in previous geometry of interaction constructions.

Factio Liberalis hispana introducit in sua causa quaestionem religiosam anno 1899. Probabiliter sibi est unica subsistendi possibilitas impulsui Factionis Conservatoris, propinqui traditionalismo alphonsino a Leone XIII alito. Quapropter proponit legislationem quae praesertim privatae docentiae, fere exclusive rellgiosae, . vegilantiam statalem refert, ac maxime et vigilantiam institutorum perfectionis evangelicae. Haec omnia faciunt quaestionem iuridicam interpretationis articuli 29 in Concordato anno 1851 facto, qui ad litterum statum ad sustinendus institutos tres masculinos determinatos cogit, non ceterorum futuro constituto. Disputatio, primum inter liberales et traditionalistas, pervenit deinde diplomatica septembre anni 1901. Prosequitur non confecta post annos nunc examinatos. Pero hos annos novissima res publica, Sagasta praeside, ad vigilandos institutos quasdam promulgat cautiones, praesertim dispositionem regiam septembre anni 1901. Aplicatione autem ulteriori monstrat intentionem duntaxat politicam. Sunt cautiones quae ad opinionem destinantur, secreto autem cum Vaticano negotiatae. Ad hoc auctor consultavit fundos Archivi Generalis Ministerii Rerum Exteriorum, quod includit partem Archivi Legationis hispanae apud Vaticanum. Consultavit etiam documenta Archivi Aedis Regiae Matritensis, et litteras cottidianas varie intentionis, et annales rerum gestarum at que recentem

Abstract. Reducing methane emissions is essential to tackle climate change. Here, we address the problem of detecting large methane leaks using hyperspectral data from the Sentinel-5P satellite. For that we exploit the fine spectral sampling of Sentinel-5P data to detect methane absorption features visible in the shortwave infrared wavelength range (SWIR). Our method involves three separate steps: i) background subtraction, ii) detection of local maxima in the negative logarithmic spectrum of each pixel and iii) anomaly detection in the background-free image. In the first step, we remove the impact of the albedo using albedo maps and the impact of the atmosphere by using a principal component analysis (PCA) over a time series of past observations. In the second step, we count for each pixel the number of local maxima that correspond to a subset of local maxima in the methane absorption spectrum. This counting method allows us to set up a statistical a contrario test that controls the false alarm rate of our detections. In the last step we use an anomaly detector to isolate potential methane plumes and we intersect those potential plumes with what have been detected in the second step. This process strongly reduces the number of false alarms. We validate our method by comparing the detected plumes against a dataset of plumes manually annotated on the Sentinel-5P L2 methane product.

This paper develops an asymptotic theory for estimated change-points in linear and nonlinear time series models. Based on a measurable objective function, it is shown that the estimated change-point converges weakly to the location of the maxima of a double-sided random walk and other estimated parameters are asymptotically normal. When the magnitude d of changed parameters is small, it is shown that the limiting distribution can be approximated by the known distribution as in Yao (1987, Annals of Statistics 15, 1321–1328). This provides a channel to connect our results with those in Picard (1985, Advances in Applied Probability 17, 841–867) and Bai, Lumsdaine, and Stock (1998, Review of Economic Studies 65, 395–432), where the magnitude of changed parameters depends on the sample size n and tends to zero as n → ∞. The theory is applied for the self-weighted QMLE and the local QMLE of change-points in ARMA-GARCH/IGARCH models. A simulation study is carried out to evaluate the performance of these estimators in the finite sample.

Introduction: Maximal oxygen uptake, VO2 & peak, among athletes is an important foundation for all training programmes to enhance competition performance. In Singapore, the VO2 & peak of athletes is apparently not widely known. There is also controversy in the modelling or scaling of maximal oxygen uptake for differences in body size – the use of ratio-scaling remains common but allometric scaling is gaining acceptance as the method of choice. Materials and Methods: One hundred fifty-eight male (age, 21.7 ± 4.9 years; body mass, 64.8 ± 8.6 kg) and 28 female (age, 21.9 ± 7.0 years; body mass, 53.0 ± 7.0 kg) athletes completed a maximal treadmill run to volitional exhaustion, to determine VO2 & peak. Results: VO2 & peak in L/min of female athletes was 67.8% that of male athletes (2.53 ± 0.29 vs. 3.73 ± 0.53 L/min), and VO2 & peak in mL/kg BM1.0/min of female athletes was 83.4% of male athletes (48.4 ± 7.2 vs. 58.0 ± 6.9 mL/kg BM1.0/min). Ratio-scaling of VO2 & peak did not create a size-free variable and was unsuitable as a scaling method. Instead, VO2 & peak, that was independent of the effect of body mass in male and female athletes, was best described using 2 separate and allometrically-derived sex-specific regression equations; these were VO2 & peak = 2.23 BM0.67 for male athletes and VO2 & peak = 2.23 BM0.24 for female athletes. Key words: Athletes, Maximal oxygen uptake, Scaling

Abstract. Deblurring is a vital image pre-processing procedure to improve the quality of images. It is a classical ill-posed problem. A new blind deblurring method based on image sparsity prior is proposed here. The proposed image sparsity prior combines patch-wise minimal and maximal pixels of latent image, and improves gradually the image sparsity during deblurring. An algorithm that is different with half quadratics splitting algorithm is applied under the maximum a posterior (MAP) framework. Experiment results demonstrate that the proposed method can keep more subtle texture and sharpened edges, reduce the artefacts in visual, and the corresponding evaluated indexes perform favourably against it of the state-of-the-art methods on synthesized, natural and remote sensing images (RSI) quantitatively.

This paper presents an automated approach to detect citrus trees from digitals surface models (DSMs) as a single source. The DSMs in this study are generated from Unmanned Aerial Vehicles (UAVs), and the proposed approach first considers the symmetric nature of the citrus trees, and it computes the orientation-based radial symmetry in an efficient way. The approach also takes into account the local maxima (LM) information to verify the output of the radial symmetry. Our contributions in this study are twofold: (i) Such an integrated approach (symmetry + LM) has not been tested to detect (citrus) trees (in orchards), and (ii) the validity of such an integrated approach has not been experienced for an input, e.g. a single DSM. Experiments are performed on five test patches. The results reveal that our approach is capable of counting most of the citrus trees without manual intervention. Comparison to the state-of-the-art reveals that the proposed approach provides notable detection performance by providing the best balance between precision and recall measures.

Abstract. Due to many problems such as diseases and pests, low fertility, and dehydration, trees need immediate actions to be taken in time of need. Since they are an important source of fruit, food, and nutrients consumed by humans, keeping track of the trees in orchards is a crucial issue in recent years. Today, drones equipped with multispectral cameras are used in precision agriculture, especially for monitoring and controlling trees. For this cause, two citrus orchards in Iran with an area of 9.2 and 2.67 hectares and a resolution of 3.6 and 0.68 cm were selected for the study area. In this study, First, tree extraction was conducted using four algorithms namely Local maxima, Image binarization, valley following, and watershed segmentation, and a proposed method that is based on the improvement of the watershed algorithm. This method achieved an overall accuracy of 87% and 81% in the two study regions which was higher than common methods. Secondly, the effect of the number of spectral bands on the accuracy of tree extraction was investigated. As a result, by adding of Red-Edge and NIR bands, the accuracy increased by about 5% and 7%. Therefore, experts suggested using NIR and Red-Edge bands besides RGB bands.

Abstract. Mapping and monitoring forest resources require collection of spatially explicit and timely remote sensing (RS) data. Although field measurements are still important, the RS-based forest inventory helps mapping large areas to be cheaper, faster, less labor intensive, and spatially more explicit. The single-photon laser (SPL) scanning data has been exploited for different forestry applications but lacks deep examination in mapping individual trees as well as being compared with ordinary laser scanning (Linear-mode, LML) data and different individual tree detection (ITD) methods. Hence, this research focuses on applying and comparing two datasets (SPL and LML) for extracting attributes of individual trees by applying two tree crown segmentation methods (local maxima and watershed segmentation) on both datasets. The results were validated over 49 field measured plots of different species, located in southern boreal forest.The SPL yielded more accurate results for both tree density and height estimation. Watershed segmentation method yielded more accurate results for tree density and height estimation in both LML and SPL datasets. Tree density was underestimated by 4.7% (rRMSE: 32.3%) for all species. Comparing tree density estimation of different species, it was most accurate in deciduous plots (rBias: −9.5, rRMSE: 17.0%). Tree height estimation with SPL explained the variations of field-measured height very well (R2 = 0.93), and was reliably accurate, underestimated by 3.4% (rRMSE: 7.0%). The mean tree height estimation was most accurate in pine plots (rBias: 4.9%, rRMSE: 1.1%). In this research, SPL represented reliable and usable point cloud data for estimating tree height and density.

Abstract. This paper presents and extends an approach for the detection of pedestrians in unstructured point clouds resulting from single MLS (mobile laser scanning) scans. The approach is based on a neural network and a subsequent voting process. The neural network processes point clouds subdivided into local point neighborhoods. The member points of these neighborhoods are directly processed by the network, hence a conversion in a structured representation of the data is not needed. The network also uses meta information of the neighborhoods themselves to improve the results, like their distance to the ground plane. It decides if the neighborhood is part of an object of interest and estimates the center of said object. This information is then used in a voting process. By searching for maxima in the voting space, the discrimination between an actual object and incorrectly classified neighborhoods is made. Since a single labeled object can be subdivided into multiple local neighborhoods, we are able to train the neural network with comparatively low amounts of labeled data. Considerations are made to deal with the varying and sparse point density that is typical for single MLS scans. We supplement the detection with a 3D tracking which, although straightforward, allows us to deal with objects which are occluded for short periods of time to improve the quality of the results. Overall, our approach performs reasonably well for the detection and tracking of pedestrians in single MLS scans as long as the local point density is not too low. Given the LiDAR sensor we used, this is the case up to distances of 22 m.

Abstract. In various studies trees have been extracted and their conditions have been examined through different detection algorithms from two main data sources including (a) point cloud and (b) raster data. The output of tree extraction is the input of the next processing steps, and the importance of these outputs is proved more than before. Tree Extraction (TE) has many applications in biomass estimation, CHM extraction, etc. All of which require high accuracy and the correct position of the trees. therefore, in this study, a comparison between tree extraction algorithms in two common sources of data has been conducted. As for the raster data, all bands are first co-registered. Afterward, the trees are separated from the background by using image processing techniques such as changing the image color space and weighted averaging on different bands. Finally, TE algorithms such as watershed segmentation, valley following, local maxima, and image binarization were applied. As for the point cloud data, TE can be conducted in the object space to compensate for the methods used in the raster space with object detection algorithms e.g., the coherence between the two trees, etc. which have been discussed in detail in this paper. In the object space, three algorithms, region-based, surface normal, and Euclidean segmentation, were implemented and discussed on the same raster data set in the photogrammetric point cloud. The results show the higher accuracy of the region-based algorithm in object-space by more than 26% in comparison with the valley following algorithm in image space.

Seven new species of the subfamily Neanurinae from north-western Iran are described and illustrated in detail. Endonura agnieskaesp. nov. differs from the most similar congener, E. reticulata (Axelson, 1905), in chaetotaxic details and the arrangement of tubercles on the dorsal side of the body. Endonura annaesp. nov. can be easily recognised by its wide labrum, the absence of chaetae C on the head and the presence of a toothed claw. Endonura schwendingerisp. nov. is especially distinctive due to the absence of chaetae A and Ocp on the head and the presence of the male ventral organ. Deutonura brevisetasp. nov. is related and most similar to D. persica Smolis, Shayanmehr & Yoosefi-Lafooraki, 2018, described recently and known from Mazandran Province in Iran. The new species can be easily distinguished by the following set of features: dark pigmented body, presence of chaetae C and Dl3 on the head, absence of microchaetae on the furca rudimentary, presence of thickened macrochaetae on dorsal side of body and absence of cryptopygy. The main characteristics of Deutonura sengletisp. nov. include a white body with dark pigmented eyes, the fusion of tubercles Di and De on the first thoracic segment and the presence of the male ventral organ. Deutonura iranicasp. nov. is superficially similar to D. gibbosa Porco, Bedos & Deharveng, 2010, a species known from the Alps and Jura in Europe, but it differs in the body colour and the number of labial chaetae and chaetae (L+So) on the head. Paravietnura rostratasp. nov., the first member of this enigmatic and intriguing genus known from Iran, is characterised by an unusually elongate ogival labrum and extreme reduction of dorsal chaetotaxy. Furthermore, new records of several other species of the subfamily: Cryptonura maxima Smolis, Falahati & Skarżyński, 2012; C. persica Smolis, Falahati & Skarżyński, 2012; Deutonura persica; Endonura longirostris Smolis, Shayanmehr, Kuznetsova & Yoosefi-Lafooraki, 2017; E. paracentaurea Smolis, Shayanmehr, Kuznetsova & Yoosefi-Lafooraki, 2017; Neanura deharvengi Smolis, Shayanmehr & Yoosefi-Lafooraki, 2018; N. muscorum (Templeton, 1835) and Protanura papillata Cassagnau & Delamare Deboutteville, 1955 are given. The present study is based on the rich material collected by Antoine Senglet and loaned by Peter J. Schwendinger.

Background:Telemedicine has found wider application in chronic diseases for encouraging tight home-monitoring in order to improve patients’ outcome (Smolen et al. 2017).In previous studies, a high feasibility and high patient-satisfaction rate was found as well as the evidence for a superior or equal effectiveness of telemedicine compared to the standard face-to-face approach, however the results were weakened by some methodological biases and wide heterogeneity of interventions, thus preventing to draw definitive conclusions (Piga et al. 2017; Najm, Gossec, et al. 2019).Objectives:In rheumatoid arthritis (RA), telemedicine may allow a tight control of disease activity while reducing hospital visits. We developed a smartphone application connected with a physician’s interface to monitor RA patients. We aimed to assess the performance of this e-Health solution in comparison with routine practice in the management of patients with RA.Methods:A 6-month pragmatic, randomized, controlled, prospective, clinical trial was conducted in RA patients with high to moderate disease activity starting a new Disease Modifying Anti-Rheumatic Drug (DMARD) therapy. Two groups were established: “connected monitoring” and “conventional monitoring”. The primary outcome was the number of physical visits between baseline and 6 months. Secondary outcomes included adherence, satisfaction, changes in clinical, functional, and health status scores (SF-12).Results:Of the 94 randomized patients, 89 completed study: 44 in the “conventional monitoring” arm and 45 in the “connected monitoring” arm. The total number of physical visits between baseline and 6 month was significantly lower in the “connected monitoring” group (0.42 ± 0.58 versus 1.93 ± 0.55; p<0.05). No differences between groups were observed in the clinical and functional scores. A better quality of life for SF-12 subscores (Role-Physical, Social-Functioning and Role-Emotional) were found in the “connected monitoring” group.Conclusion:According to our results, a connected monitoring reduces the number of physical visits while maintaining a tight control of disease activity and improving quality of life in patients with RA starting a new treatment.References:[1] Najm, Aurelie, Laure Gossec, Catherine Weill, David Benoist, Francis Berenbaum, and Elena Nikiphorou. 2019. “Mobile Health Apps for Self-Management of Rheumatic and Musculoskeletal Diseases: Systematic Literature Review.”JMIR MHealth and UHealth7 (11): e14730.https://doi.org/10.2196/14730.[2] Piga, Matteo, Ignazio Cangemi, Alessandro Mathieu, and Alberto Cauli. 2017. “Telemedicine for Patients with Rheumatic Diseases: Systematic Review and Proposal for Research Agenda.”Seminars in Arthritis and Rheumatism47 (1): 121–28.https://doi.org/10.1016/j.semarthrit.2017.03.014.[3] Smolen, Josef S, Robert Landewe, Johannes Bijlsma, Gerd Burmester, Katerina Chatzidionysiou, Maxime Dougados, Jackie Nam, et al. 2017. “EULAR Recommendations for the Management of Rheumatoid Arthritis with Synthetic and Biological Disease-Modifying Antirheumatic Drugs: 2016 Update.”Annals of the Rheumatic Diseases76 (6): 960–77.https://doi.org/10.1136/annrheumdis-2016-210715.Disclosure of Interests:None declared

BackgroundThe European League Against Rheumatism (EULAR)1 recently provided updated guidelines regarding the initiation and modification of disease-modifying antirheumatic drug (DMARD) therapy in patients with Rheumatoid Arthritis (RA). Therefore, real-world evidence studies are warranted to provide insights into first-line DMARD utilization and durability of response in the second-line setting.ObjectivesTo analyze RA treatment patterns in real-world data and compare durability of response between second-line DMARDs + anti-TNF (TNFi) therapies vs. TNFi monotherapy.MethodsElectronic health records (EHRs) from a large health system in the Northeast US were used to identify RA patients. Lines of therapy were defined based on confirmed prescriptions for DMARDs and TNFi therapies. Time to next treatment (TTNT) was the primary outcome to estimate durability of response. Time-to-event analyses were performed using Kaplan-Meier and log-rank test methods. In addition, a Cox Proportional-Hazards (CoxPH) model was used to evaluate covariates as independent predictors of disease progression.ResultsOur study cohort consisted of 8,040 patients who had at least one line of therapy for RA. Conventional synthetic DMARDs (csDMARDs) were the predominant first line of therapy in this dataset (71.3%), followed by TNFi alone (11.1%) or TNFi combined with csDMARD (9.1%) (Figure 1).For patients who had csDMARD as their first line of therapy, 22.93% progressed to second line treatment. Among them 36.2% patients were TNFi with or without in combination with csDMARDs. In the second-line, TNFi + csDMARDs were associated with a longer TTNT (median time: 13.1 months vs 6.1 months, P < 0.005) compared to TNFi monotherapy. The multiple variable CoxPH model (adjusted for age, gender, and race) demonstrated that second-line TNFi + csDMARDs had a lower hazard rate when compared to TNFi monotherapy (HR = 0.74, 95% CI: 0.36 - 1.12, p < 0.005).ConclusionWe demonstrated the first comprehensive treatment sequencing patterns in RA from a real-world setting. As a second-line therapy for patients with inadequate response to csDMARDS, the TNFi + csDMARDs combination may improve duration of response when compared to TNFi monotherapy. Results from this study will inform future sequencing strategies to improve patient outcomes.References[1]Smolen, Josef S., Robert B. M. Landewé, Johannes W. J. Bijlsma, Gerd R. Burmester, Maxime Dougados, Andreas Kerschbaumer, Iain B. McInnes, et al. 2020. “EULAR Recommendations for the Management of Rheumatoid Arthritis with Synthetic and Biological Disease-Modifying Antirheumatic Drugs: 2019 Update.” Annals of the Rheumatic Diseases 79 (6): 685–99.Disclosure of InterestsLei Ai: None declared, Mitchell Higashi: None declared, Kyeryoung Lee: None declared, Zongzhi Liu: None declared, Lan Jin: None declared, Kalpana Raja: None declared, Yun Mai: None declared, Tomi Jun: None declared, William Oh Consultant of: JanssenPfizer, Aviva Beckmann: None declared, Emilio Schadt: None declared, Zachary Schadt: None declared, Rick Wallsten: None declared, Ediz Calay: None declared, Andrew Kasarskis: None declared, Qi Pan: None declared, Eric Schadt Speakers bureau: Eli Lilly, Consultant of: SAB of Eli LillyCelgene, Xiaoyan Wang: None declared

Background:Previously, the results of phase II AURORA clinical study of levilimab in subjects with active rheumatoid arthritis (RA) have been reported1. Here we report topline 24-weeks results of preliminary primary efficacy and safety analysis of phase 3 double-blind, placebo-controlled randomized clinical study (SOLAR).Objectives:To confirm that levilimab in combination with methotrexate is superior to placebo in combination with methotrexate in achieving ACR20 at week 12 and low disease activity (LDA) at week 24 in subjects with methotrexate (MTX) resistant active RA.Methods:The study is ongoing at 21 clinical sites in Russia and Belarus. All randomized subjects have completed 24 weeks of study between November 2019 and January 2021.154 adults, aged ≥18 years with the diagnosis of RA (ACR 2010) for at least 24 weeks, and confirmed disease activity at screening despite treatment with MTX for the last 12 weeks (in a stable dose 15-25 mg/week, for at least 4 weeks) were randomly assigned (2:1) to receive either levilimab (162 mg, SC, QW) + MTX (n=102) or placebo + MTX (n=52). The randomization and treatment allocation were carried out by a central computer-based system. Subjects, caregivers, and those assessing the outcomes were blinded to group assignment.The hypothesis of superiority of levilimab over placebo was tested for two co-primary efficacy outcomes: proportion of subjects who achieved ACR20 at week 12 and proportion of subjects who achieved LDA of RA (DAS28-CRP <3.2) at Week 24 of the study.For ethical reasons, subjects who haven’t achieved minimal clinical response at week 12 (≥20% reduction in the number of tender/swollen joints; 66/68) received rescue therapy at the discretion of the Investigator, and all subsequent efficacy assessments for those were considered missing.For the primary efficacy analysis, subjects with missing data due to study discontinuation or rescue therapy prescription were considered non-responders (non-responder imputation, NRI). Otherwise, the analysis was performed on observed cases.Safety was assessed through monitoring of adverse events (AEs).Results:The primary analysis was based on 149 randomized subjects (n=99 and n = 50) for ACR20 and 154 randomized subjects (n= 102 and n = 52) for LDA.70/99 (71%) of subjects who received levilimab and 20/50 (40%) who received placebo achieved ACR20 response at week 12. The difference in proportion was 30% with a lower bound of 97.5% CI 12.8%; p=0.0003 (Pearson’s chi-squared test).53/102 (52%) of subjects received levilimab and 3/52 (6%) received placebo achieved LDA at week 24. The difference in proportion was 46% with a lower bound of 97.5% CI 31.2 %; p<0.0001 (Pearson’s chi-squared test).The safety population included all subjects, who received investigational product (n=154).The most common adverse events (reported in ≥5% of subjects) in levilimab and placebo arms, respectively were: blood cholesterol increase (19% vs. 10%), ALT increase (11% vs. 8%), lymphocyte count decrease (9% vs. 8%), blood bilirubin increase (11% vs. 0%), blood triglycerides increase (9% vs. 2%), AST increase (7% vs. 4%), IGRA with M.tuberculosis antigen positive (5% vs. 6%), ANC decrease (8% vs. 0%). No deaths were occurred.Conclusion:The study confirmed superior efficacy of levilimab + MTX over placebo + MTX in subjects with MTX resistant active RA. No new safety signals were detected.Trial registration: Clinicaltrials.gov identifier NCT04397562References:[1]Mazurov V, Zotkin E, Ilivanova E, et al. FRI0114 EFFICACY OF LEVILIMAB, NOVEL MONOCLONAL ANTI-IL-6 RECEPTOR ANTIBODY, IN COMBINATION WITH METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS: 1-YEAR RESULTS OF PHASE 2 AURORA STUDY. Annals of the Rheumatic Diseases 2020;79:637-638.Acknowledgements:We thank all contributors to the SOLAR clinical trialDisclosure of Interests:V Mazurov: None declared, Maxim Korolev: None declared, Alena Kundzer: None declared, Nikolaj Soroka: None declared, Aleksander Kastanayan: None declared, Tatyana Povarova: None declared, Tatyana Plaksina: None declared, Olga Antipova: None declared, Diana Kretchikova: None declared, Svetlana Smakotina: None declared, Oksana Tciupa: None declared, Tatiana Raskina: None declared, Tatyana Kropotina: None declared, Olga Nesmeyanova: None declared, Tatiana Popova: None declared, Ekaterina Dokukina Employee of: JSC BIOCAD, Aleksandra Plotnikova Employee of: JSC BIOCAD, Anton Lutskii Employee of: JSC BIOCAD, Arina Zinkina-Orihan Employee of: JSC BIOCAD

BackgroundPreviously, 24-week results of phase III double-blind, placebo-controlled randomized clinical study (SOLAR) of levilimab in subjects with active rheumatoid arthritis (RA) proved a superiority of levilimab over placebo1. Here we present 1-year efficacy and safety data of the open-label period of the SOLAR study.ObjectivesTo evaluate the efficacy and safety of levilimab in combination with methotrexate (MTX) in subjects with MTX resistant active RA.MethodsThe study was conducted at 21 clinical sites in Russia and Belarus. All randomized subjects had completed the study between November 2019 and October 2021.154 adults, aged ≥ 18 years with confirmed diagnosis of RA1 were randomly assigned (2:1) to receive either levilimab, 162 mg, SC (LVL QW) + MTX (n=102) or placebo (PBO) + MTX (n=52).After W24 of the study all subjects continued to receive open label levilimab +MTX. Subjects who had achieved DAS28-CRP ≤ 2.6 at W24 were switched to maintenance (Q2W) regimen of levilimab + MTX at W28: LVL QW/Q2W arm (n=27) and PBO/LVL Q2W arm (n=1). Those with DAS28-CRP > 2.6 at W28 continued with levilimab QW regimen + MTX: LVL QW/QW arm (n=75) and PBO/LVL QW arm (n=51).The efficacy analysis was done in a population of all randomized subjects (n=154). Those with missing data due to study discontinuation or rescue therapy prescription were considered non-responders. Otherwise, the analysis was performed on complete cases.Safety was assessed through monitoring of adverse events (AEs) in a population of those, who received at least one dose of LVL (n=152). Two subjects randomized to receive placebo were discontinued within first 24 weeks of the study, thus did not received any dose of levilimab and were excluded from safety analysis.ResultsObviously, better response to the treatment was observed in LVL QW/Q2W arm as it was composed of those who had reached DAS28-CRP ≤ 2.6 at W24. At this time point 15/27 (55.6%) of them achieved ACR70; 23/27 (85.2%) achieved DAS28-CRP remission (< 2.6) and 7/27 (25.9%) achieved ACR/EULAR2011 remission of RA. After switching to LVL Q2W, rates of ACR70 and DAS28-CRP < 2.6 did not significantly changed until W52: 17/27 (63.0%) and 21/27 (77.8%), respectively, yet the proportion of subject with ACR/EULAR 2011 remission further increased and reached 12/27 (44.4%).LVL QW/QW arm was diminished by subjects who had achieved high response to treatment at W24 and composed LVL QW/Q2W arm. Thus, the ACR70, and remissions rate in this arm were close to zero at W24. However, continuation of LVL QW in those who had not achieved DAS28-CRP ≤ 2.6 at W24 induced ACR70 response in 37/75 (36.0%), DAS28-CRP remission in 35/75 (46.7%) and ACR/EULAR 2011 remission in 8/75 (10.7%) at W52.The most common adverse events (reported in ≥5% of subjects) were blood cholesterol increase (30.3%), ALT increase (23.0%), lymphocyte count decrease (17.1%), ANC decrease (16.4%). blood triglycerides increase (13.8%), bilirubin increase (11.2%), AST increase (9.9%), WBC decrease (9.9%), IGRA with M.tb antigen positive (7.2%) and injection site reactions (5.9%). No deaths were occurred.ConclusionOpen label period confirmed the lasting efficacy and safety of levilimab in combination with MTX in subjects with MTX resistant active RA and suggested the possibility of switching to maintenance (Q2W) regimen of levilimab in those who achieved remission of RA at week 24.Trial registration: Clinicaltrials.gov identifier NCT04397562References[1]Mazurov V, Korolev M, Kundzer A, et al POS0624 EFFICACY AND SAFETY OF LEVILIMAB IN COMBINATION WITH METHOTREXATE IN SUBJECTS WITH ACTIVE RHEUMATOID ARTHRITIS: PHASE III, DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED TRIAL Annals of the Rheumatic Diseases 2021;80:550-551.AcknowledgementsWe thank all contributors to the SOLAR clinical trialDisclosure of InterestsV Mazurov: None declared, Maxim Korolev: None declared, Andrei Pristrom: None declared, Alena Kundzer: None declared, Nikolaj Soroka: None declared, Aleksander Kastanayan: None declared, Tatyana Povarova: None declared, Tatyana Plaksina: None declared, Olga Antipova: None declared, Diana Kretchikova: None declared, Svetlana Smakotina: None declared, Oksana Tciupa: None declared, Ekaterina Puntus: None declared, Tatiana Raskina: None declared, Ludmila Shilova: None declared, Tatyana Kropotina: None declared, Olga Nesmeyanova: None declared, Tatiana Popova: None declared, Irina Vinogradova: None declared, Iulia Linkova Employee of: JSC BIOCAD, Aleksandra Plotnikova Employee of: JSC BIOCAD, Polina Pukhtinskaia Employee of: JSC BIOCAD, Arina Zinkina-Orikhan Employee of: JSC BIOCAD, Anna Eremeeva Employee of: JSC BIOCAD, Anton Lutckii Employee of: JSC BIOCAD

ABSTRAK Penelitian ini bertujuan untuk memetakan penelitian-penelitian sebelumnya tentang audit syariah dan perannya dalam meningkatkan kepatuhan syariah di lembaga keuangan syariah (LKS). Penelitian ini juga menguraikan tantangan yang dihadapi oleh LKS dan solusi dalam mengimplementasikan audit syariah. Sebanyak 308 publikasi diperoleh dari database Google scholar, Emerald Insight, Research Gate, Crossref, Microsoft Academic and Pubmed yang diakses dengan perangkat lunak Publish or Perish (PoP) dalam kurun waktu 2008-2021. Studi ini menerapkan analisis bibliometrik menggunakan VOSviewer, yang mengubah metadata publikasi menjadi visualisasi sesuai dengan co-occurrence. Hasil penelitian ini menemukan bahwa audit syariah telah diterapkan di beberapa negara yang didominasi oleh Malaysia. Sebagian besar praktik audit syariah merupakan bagian dari fungsi audit internal. Audit syariah diidentifikasi sebagai mekanisme untuk memastikan kepatuhan syariah. Tantangan utama dalam pelaksanaan audit syariah antara lain: kurangnya kerangka dan standar audit syariah yang menyebabkan perselisihan di antara praktisi LKS, kurangnya auditor syariah yang berkualitas yang memiliki pengetahuan syariah yang memadai dan terlatih dengan baik, audit syariah dianggap menciptakan masalah inefisiensi. Peran komite tata kelola syariah dan dewan pengawas syariah direkomendasikan agar lebih optimal untuk memastikan efektivitas audit syariah. Penelitian ini memberikan pembahasan komprehensif tentang audit syariah, perannya dalam meningkatkan kepatuhan syariah, tantangan dan solusi yang ditawarkan belajar dari berbagai negara. Kata Kunci: Audit syariah, kepatuhan syariah, lembaga keuangan syariah, bibliometrik. ABSTRACT This study aimed to map out previous studies on sharia auditing and its role in improving sharia compliance in Islamic financial institutions (IFIs). It also outlined the challenges faced by IFIs and solutions in implementing shariah audit. A total of 308 publications were obtained from the Google scholar database, Emerald Insight, Research Gate, Crossref, Microsoft Academic and Pubmed which were accessed using the Publish or Perish (PoP) software in the 2008-2021 period. This study finds that sharia audits have been implemented in several countries, dominated by Malaysia. Most shariah audit practices are part from internal audit function of IFIs. Sharia audit is identified as a mechanism to assure shariah compliance. The main challenges in implementing sharia audit include: a lack of framework and standard of shariah audit that led to dispute among IFIs practitioners, a lack of qualified shariah auditors who have an adequate shariah knowledge and well trained , shariah audit identifed creating an efficiency issue. The role of the shariah governance committee and the shariah supervisory board may be optimized to ensure the effectiveness of shariah audit. 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RECONSTRUÇÃO DE MAXILA ATRÓFICA UTILIZANDO ENXERTO ÓSSEO AUTÓGÊNO DE CRISTA ILÍACA – RELATO DE CASO CLÍNICO Autores: José Mário FRAIZ; Nelson Luis Barbosa REBELLATO; Delson João COSTA; Paulo Roberto MÜLLER; Ricardo PASQUINE. Universidade Federal do ParanáCurso de Pós Graduação em Cirurgia e Traumatologia Buco-Maxilo-Facias Área de Abrangência: Cirurgia e Implantodontia A reabilitação oral de pacientes com maxilas atróficas tem sido bastante discutida na literatura. Esse trabalho apresenta a técnica de reconstrução de maxila atrófica, através de enxertia óssea utilizando osso ilíaco. Uma quantidade mínima de tecido ósseo é necessária para a inserção e manutenção da estabilidade do implante, após a perda dos dentes o processo alveolar maxilar sofre progressiva e irreversível reabsorção, tanto vertical quanto horizontal, podendo atingir um estágio de pneumatização do seio maxilar. Isso contra-indica a instalação de implantes. A literatura sugere que quando há a pneumatização acentuada do seio maxilar e há reabsorção de rebordo alveolar, a técnica de sinus Lift, introduzida primeiramente por TANTUM em 1970, e revisada por MISCH na década de 80, é indicada. Dentre as áreas doadoras, que podem ser crista óssea do ilíaco, calota craniana, costela e tíbia, a crista óssea do ilíaco tem sido uma das opções de escolha por apresentar baixo índice de complicações pós-operatórias, baixa morbidade e menor reabsorção pós-cirúrgica. Esta técnica permite, após seis meses da cirurgia, a instalação de implantes osseointegrados para posterior reabilitação protética. O presente trabalho apresenta um caso clínico de enxertia ósseo de crista ilíaca em maxila atrófica para posterior reabilitação com implantes. Palavras-chave: enxerto ósseo; reabilitação bucal; cirurgia; implantes dentários.Referências Bibliográficas: 1-ABRAHAMS, J. J.; HAYT,M.W.; ROCK, R. Sinus lift procedure of the maxilla in patients with inadequate bone for dental implants: radiographic appearance. Audio journal review-General surgery, Nova York, v. 174, p.1289-1292, 2000.2-AJEN, S. A. Análise por tomografia computadorizada do enxerto autógeno na cirurgia de “sinus lift”. Revista brasileira de radiologia, São Paulo, v. 38, n.1, p.25-31. 2005.3-BEZERRA, F. J. B.; LENHARO, A. Terapia clínica avançada em implantodontia. São Paulo, Artes Médicas, 2002.4- BREINE, U. & BRÅNEMARK, P.I. Reconstruction of alveolar jaw bone. An experimental and clinical study of immediate and preformed autologous bone grafts in combination with osseointegrated implants. Scandinavian journal of plastic and reconstructive surgery and hand surgery. Supplementum, Stockolmo, p. 14: 23-48, 1980.5- FUGAZZOTTO PA, VLASSIS J. LONG. Term success of sinus augmentation using various surgical approaches and grafting materials. International Journal of Oral and Maxillofacial Implants, Lombard/IL, p.13, 52 -58, 19986- HARBON, S.; CHARTOUNI, M. & RICBOURG, B. Morbidity of iliac bone grafts. A study a propos of 100 consecutive cases. Annales de chirurgie plastique et esthetique, Paris, p. 36, 45- 50, 1991.7-LIM, T. J.; CSILLAG, A.; IRINAKIS, T.; NOKIANI, A.; WIEBE, C.B. Intentional angulation of an implant to avoid a pneumatized maxillary sinus: a case report. Journal of the Canadian dental association, Toronto, v. 70, n.3, p.164-16, 2004.8- MISCH, C.M. RIGDE. Augmentation using mandibular ramus bone grafts for the placement of dental implants: presentation of a technique. Practical periodontics and aesthetic dentistry, Nova York, p. 127-135, 1996.9-NEVES. Jornal Brasileiro de Implantodontia oral. Otimização da estética: uma abordagem dos tecidos mole e duro. Belo Horizonte: Traccio arte e design, 2002.10- RAGHOEBAR GM, BROUWER TJ, REINTSEMA H, VAN OORT, RP. Augmentation of the maxillary sinus floor with autogenous bone for the placement of endosseous implants. Journal of Oral and Maxillofacial Surgery, Filadélfia, p. 51, 1198 -1203, 1993.11- WHEELER SL, HOLMO RE, CALHOUN CJ. Six-year clinical and histologic study of sinus-lift grafts. International Journal of Oral and Maxillofacial Implants, Lombard/IL ,p.-11,26 -34, 1996.