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Journal articles on the topic 'Annona muricata leaf extract and wistar rats'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Agossou Esse, Akotegnon Rodrigue, Savoeda Perside, Behanzin G. Justin, and Sezan Alphonse. "Evaluation of the antiproliferative activity of three types of Annona muricata extract in the traditional treatment of cervical cancer induced in Wistar rats." International Journal of Science and Research Archive 9, no. 1 (2023): 308–17. http://dx.doi.org/10.30574/ijsra.2023.9.1.0170.

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This study was concerned with the evaluation of the antiproliferative activity of Annona muricata in the traditional treatment of cervical cancer induced in Wistar rats. The aim of the present work was to compare the effect of ethyl, dichloromethane and ethyl acetate extracts of Annona muricata leaves to determine the most effective one on cervical cell differentiation in wistar rats. For this purpose, we made three extracts namely: ethyl extract, dichloromethane and ethyl acetate) from dried leaf powder of Annona muricata. The antiproliferative (anticancer) activity was evaluated by assaying

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A.A., Oladejo,, Okeke, C.B., Okeke C.M., et al. "Protective Effect of Annona muricata Leaf Extract against Electrolytes Imbalance in Wistar Rats Induced with Acute Myocardial Infarction." Journal of Advances in Medical and Pharmaceutical Sciences 26, no. 12 (2024): 120–28. https://doi.org/10.9734/jamps/2024/v26i12737.

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Annona muricata, a tropical fruit known for its medicinal properties, has been investigated for its potential cardioprotective effects, particularly in treating acute myocardial infarction (AMI), a critical condition caused by blocked coronary arteries. This study investigates protective effect of Annona muricata leaf extract against electrolytes imbalance in wistar rats induced with acute myocardial infarction. Thirty (30) wistar rats were randomly grouped into five classes (A, B, C, D and E) of six rats each. Groups A, B and C were pre-treated with 100mg/kg, 200mg/kg and 400mg/kg of Annona m

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Nze, P.O., O.E. Edebiri, O.H. Blackie, et al. "Protective Effects of Annona Muricata Leaf Extract on Semen Quality in Male Wistar Rats." Journal of Surgical Nursing and Post Operative Nursing Care 3, no. 2 (2025): 1–8. https://doi.org/10.5281/zenodo.15281266.

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<em>The aim of this study is to determine the protective effects of <strong>Annona Muricata</strong> leaf extract on semen quality in male wistar rats. A total of 78 adult male rats obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study</em><em>. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. </em><em>Prostate hyperplasia was induced in the rats via daily sub

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Nze, P.O., O.E. Edebiri, O.H. Blackie, et al. "Liver Protective Effects of Annona Muricata Leaf Extract in Male Wistar Rats." Advanced Research and Reviews in Geriatric Nursing & Health Sciences 2, no. 1 (2025): 36–45. https://doi.org/10.5281/zenodo.15087218.

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<em>Finding out how Annona Muricata leaf extract protects the liver in wistar rats is the goal of this study. A total of 78 adult male rats obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study</em><em>. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. </em><em>Prostate hyperplasia was induced in the rats via daily sub-cutaneous administration of testosterone

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Nweke, Elizabeth Obioma, and Frank Chinedu Akpuaka. "The effect of ethanolic extract of Annona muricata leaf on the basal ganglia." GSC Biological and Pharmaceutical Sciences 6, no. 3 (2019): 040–44. https://doi.org/10.5281/zenodo.4295852.

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<em>Annona muricata</em> (Linn.) is an evergreen tropical tree of the Annonaceae family that possesses phytotherapeutic bioactive compounds known as annonaceous acetogenins effective for the treatment of cancers and several diseases. This study investigated the effect of ethanolic extract of <em>Annona muricata </em>leaf on the basal ganglia. Twenty four (24) adult wistar rats were randomly divided into four groups (A, B, C & D) of six animals each. Group A served as the control and received 2 ml/kg of distilled water; the experimental groups B, C & D were orally adminis

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Nze, P.O., O.E. Edebiri, O.H. Blackie, et al. "Ameliorating Effects of Annona Muricata Leaf Extract on Hormonal Profile in Male Wistar Rats." Journal of Applied Nursing Research and Education 3, no. 2 (2025): 15–23. https://doi.org/10.5281/zenodo.15300873.

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<em>A total of 78 adult male rats obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study</em><em>. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. </em><em>Prostate hyperplasia was induced in the rats via daily sub-cutaneous administration of testosterone propionate (5 mg/kg body weight) for 28 days. Sixty rats used for this segment of the study were assigned

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Nze, P.O., O.E. Edebiri, O.H. Blackie, et al. "Renal Protective Function of Annona Muricata Leaf Extract in Male Wistar Rats." Journal of Trauma, Orthopaedic and Urological Nursing 3, no. 2 (2025): 1–9. https://doi.org/10.5281/zenodo.15130246.

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<em>The aims of this study is to determine the renal protective function of annona muricata leaf extract in male Wistar rats. A total of 78 adult male rats obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. Prostate hyperplasia was induced in the rats via daily sub-cutaneous administration of testosterone pr

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F.C., Chukwu,, Enemali, M.O., Oladejo, A.A., et al. "Cardio-protective Activities of Annona muricata Leaf Extract in Isoproterenol Myocardial Infarction-Induced Wistar Rats." Cardiology and Angiology: An International Journal 14, no. 1 (2025): 82–91. https://doi.org/10.9734/ca/2025/v14i1476.

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Cardiovascular disease (CVD) is a severe heart condition characterized by impaired blood flow to the heart muscle, leading to tissue damage and dysfunction. Among different medicinal plants, Annona muricata is now becoming more attractive because of its therapeutic potentials, especially in the prevention and treatment of cardiovascular related disorders, particularly myocardial infarction. Hence, this study was carried out to evaluate the cardio-protective activity of Annona muricata in isoproterenol-induced myocardial infarction using animal model. Thirty (30) male wistar rats were randomly

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Nze, P.O., O.E. Edebiri, O.H. Blackie, et al. "Ameliorating Effects of Annona Muricata Leaf Extract on Hematological Parameters in Male Wistar Rats." Research and Reviews: Journal of Dermatology Nursing 2, no. 1 (2025): 34–39. https://doi.org/10.5281/zenodo.15146101.

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<em>This study aims to determine the ameliorating effects of annona muricata leaf extract in heamatological parameters in male wistar rats. A total of 78 adult male rats obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study</em><em>. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. </em><em>Prostate hyperplasia was induced in the rats via daily sub-cutaneous a

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Nze, P.O., O.E. Edebiri, O.H. Blackie, et al. "Ameliorating Effects of Annona Muricata Leaf Extract on Lipid Profile in Male Wistar Rats." Journal of Cardiovascular, Cardiopulmonary Rehabilitation Nursing 3, no. 1 (2025): 32–38. https://doi.org/10.5281/zenodo.15062691.

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<em>This study aims to determine the ameliorating effects of annona muricata leaf extract in lipid profile in male wistar rats. </em><em>A total of 78 adult male rats obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study</em><em>. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. </em><em>Prostate hyperplasia was induced in the rats via daily sub-cutaneous admi

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Edebiri, O.E., O.H. Blackie, M. Uwuigbe, et al. "Cardiomyocytes Modulating Effects of Annona Muricata (Soursop) Leaf Extract on Testosterone - Induced Benign Prostatic Hyperplasia In Male Wistar Rats." Journal of Cardiovascular, Cardiopulmonary Rehabilitation Nursing 3, no. 2 (2025): 1–10. https://doi.org/10.5281/zenodo.15221804.

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<em>This present study aimed to determined Cardiomyoctes modulating effects of annona muricata (soursop) leaf extract on testosterone – induced benign prostatic hyperplasia. </em><em>A total of 78 adult male rats obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study</em><em>. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. </em><em>Prostate hyperplasia

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Nze, P.O., O.E. Edebiri, O.H. Blackie, et al. "Ameliorating Effects of Annona Muricata Leaf Extract in Inflammatory Markers in Male Wistar Rats." Research and Reviews: Journal of Dermatology Nursing 2, no. 1 (2025): 26–33. https://doi.org/10.5281/zenodo.15081824.

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<em>This present study aimed to investigate the ameliorating effects of annona muricata leaf extract on inflammatory markers in male wistar rats. A total of 78 adult male rats obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study</em><em>. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. </em><em>Prostate hyperplasia was induced in the rats via daily sub-cutan

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Sovia, E., W. Ratwita, D. Wijayanti, and D. R. Novianty. "HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 3 (2017): 170. http://dx.doi.org/10.22159/ijpps.2017v9i3.16402.

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Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf eth

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Olude, Olayemi Mujidat, and Frank Osarumwense Omoregie. "Antioxidant potential of ethanol extract of Annona muricata leaves and its inhibitory effect on lipid peroxidation in 1,2-dimethylhydrazine induced colon carcinogenesis." Bio-Research 21, no. 3 (2023): 2079–90. http://dx.doi.org/10.4314/br.v21i3.2.

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Annona muricata, as it is scientifically called but known in most parts of Nigeria as soursop. A fruit tree with various therapeutic uses, the plant belongs to the family of Annonaceae and has several medicinal properties. The medicinal properties of Annona muricata are well known, and they can be used to treat a variety of illnesses and conditions. Effects of ethanol extract of Annona muricata leaves (EEAML) on the enzymatic antioxidants of the kidney and colon in Wistar rats induced with 1, 2 Dimethylhydrazine (DMH) at 25 mg/kg bodyweight s.c. were investigated in this study. Thirty-six male

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PRATAMA, RIFKY YOGA, NITA PRANITASARI, and DIAH PURWANINGSARI. "Pengaruh Ekstrak Daun Sirsak Terhadap Gambaran Histopatologi Pankreas Rattus Norvegicus Jantan yang Diinduksi Aloksan." Hang Tuah Medical journal 17, no. 2 (2020): 116. http://dx.doi.org/10.30649/htmj.v17i2.159.

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<p><strong>ABSTRACT</strong></p><p> Diabetes melitus is a metabolic disorder characterized by an increase in blood glucose levels caused by disruption of the pancreas in producing insulin. Alloxan is a substrate that can trigger the condition of hyperglycemia which can cause diabetes because of its toxic nature to pancreatic beta cells. Damage to pancreatic beta cells is caused by Reactive Oxygen Species (ROS) which causes necrosis in the pancreatic beta cells. Soursop leaf extract (Annona muricata L.) has antioxidants such as flavonoids and tannins which can inhi

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Nze, P.O., A.A. Nwankwo, O.E. Edebiri, et al. "The Protective Effects of Annona Muricata (Soursop) Leaf Extract Against Testosterone – Induced Prostate Hyperplasia and Reproductive Dysfunction in a Male Rat Model." Journal of Trauma, Orthopaedic and Urological Nursing 3, no. 1 (2025): 53–69. https://doi.org/10.5281/zenodo.15074346.

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<em>In a male rat model, the purpose of this study was to examine the preventive effects of annona muricata leaf extract against testosterone-induced prostate enlargement and reproductive failure. </em><em>A total of 78 adult male rats was obtained from the laboratory animal production unit of the Department of Physiology, Abia State University, Uturu were used for the different segments of the study</em><em>. Eighteen of the rats were used for acute toxicity/lethal dose evaluation of the extract while the remaining sixty (60) were used for the testosterone-induced hyperplasia study. </em><em>

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Ejovwoke Marcellinus Arhoghro, Ebitimi Peter Berezi, Sylvanus Beredugo, and I Omeodu Steve. "Annona muricata (Soursop) leaves extract mitigates cyclophosphamide induced reproductive toxicity in male Wistar rats." World Journal of Advanced Pharmaceutical and Medical Research 4, no. 1 (2023): 007–16. http://dx.doi.org/10.53346/wjapmr.2023.4.1.0054.

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Background: Cyclophosphamide (CP) is an anticancer and immunosuppressive agent commonly used in men of reproductive age. Annona muricata(soursop) is a tropical plant with a widely acclaimed history of various therapeutic properties. Objective: This study was aimed at determining the effect of the ethanolic leaf extract of Annona muricata on the reproductive system of male rats treated with cyclophosphamide. Materials and Methods: Twelve (n-12) male wistar rats were randomly divided into three groups of four rats each. Group 1 served as control and received only feed and water. Group 2 was admi

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Abireh, Ifeanacho Ezeteonu, Chiadikobi Lawrence Ozoemena, and Alasia Moses Onisojime. "Annona Muricata ethanolic leaf extract potentiates cyclophosphamide-induced jejunal toxicity." EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH 11, no. 3 (2024): 361–66. https://doi.org/10.5281/zenodo.10806458.

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The practice of combination therapy of herbal concoctions with conventional medications is evident in Nigeria, however with numerous undesired effects. Annona muricata leaves alcohol-based concoctions have been deployed for the treatment of cancer and some other ailments, sometimes in combination with other cytotoxic drugs such as cyclophosphamide, thus, a heightened interest in understanding their possible synergism or mitigating effects in recent studies. Cyclophosphamide has been deemed cytotoxic and therefore in high  concentrations can result in devastating effects on normal tissues.

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Ajayi, Abigael A., Benjamin A. Ajayi, and Tolulope F. Ajayi. "Assessing the Impact of Annona muricata Aqueous Extract on Liver Enzymes in Wister Rats Exposed to Paracetamol Over Dose." International Journal of Biochemistry Research & Review 33, no. 5 (2024): 91–96. http://dx.doi.org/10.9734/ijbcrr/2024/v33i5879.

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Aims: This study examines the effect of the aqueous leaf extract of Annona Muricata on liver enzymes in wister rats using the spectrophotometric method. Methodology: 20 Wister rats were divided into groups A, B, C, and D, of 5 rats each, housed, fed, and the experimental groups administered treatments orally in distilled water (10 ml/kg) by means of orogastric cannula for 14 days. 500g of the plant powder was submerged for 72 hours 1500ml of distilled water. The sample was taken with a rotating evaporator, an electrical evaporator extraction apparatus. With water heated to 45°C, the solvent wa

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Olubodun, Stella Oghomwen, and Kingsley Chukwunonso Agu. "Influence of Annona muricata (Soursop) on Colorectal Tissues of Wistar Rats." Nigerian Journal of Physiological Sciences 37, no. 1 (2022): 127–35. http://dx.doi.org/10.54548/njps.v37i1.16.

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Annona muricata (AMC), is a tropical plant species of the Annonaceae family known for its medicinal uses in ameliorating and/or protecting several organs and tissues in the body. In this study we elucidated the influence of the methanol extracts of AMC leaf and stem bark on the biochemical and histological integrity of the colorectum. Different doses (100, 200, 400, 600, and 800mg of extract/kg body weight) of methanol extracts of the leaves and stembark were orally administered to adult male Wistar rats of average weight (100 - 150 g) for 28 days. At the end of the experimental period, the ra

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Victor, Okomayin, and P. Okolie N. "PROTECTIVE EFFECT OF METHANOL EXTRACT OF ANNONA MURICATA (SOURSOP) LEAVES AGAINST BROMATE-INDUCED KIDNEY AND LIVER DAMAGE IN WISTAR RATS." Acta Biology Forum 02, no. 02 (2023): 10–17. https://doi.org/10.5281/zenodo.8330121.

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The present study investigated the protective effect of methanol leaf extract of <em>Annona muricata </em>(soursop) against bromate-induced kidney and liver damage in male albino Wistar rats. After acclimatization to laboratory conditions for 7 days, 36 rats were randomly and equally assigned to 6 groups. Five groups received bromate ion at a dose of 60 mg/kg body weight (bwt) via gavage. Bromate-exposed rats in the negative control (group II) were untreated, while 3 groups of bromate-exposed rats (III, IV, and V) were co-administered graded doses of <em>Annona muricata</em> extract (200, 300,

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Usunobun, Usunomena, and Ngozi Okolie. "Annona muricata prevent hepatic fibrosis by enhancing lysosomal membrane stability and suppressing extracellular matrix protein accumulation." International Journal of Medicine 4, no. 1 (2016): 10. http://dx.doi.org/10.14419/ijm.v4i1.5784.

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<p><strong>Background:</strong> Hepatic fibrosis is a pre-pathologic state of cirrhosis, which plays a pivotal role in the pathogenesis of hepatocellular carcinoma (HCC). This study was carried out to evaluate the hepatoprotective effect of <em>Annona muricata</em> leaves on extracellular matrix (ECM) accumulation, lysosomal membrane integrity and liver damage in dimethylnitrosamine (DMN)-induced fibrotic rats.</p><p><strong>Methods:</strong> Healthy adult male wistar rats were divided into four groups. Group I rats received normal saline a

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Agu, Kingsley C., and Stella O. Olubodun. "Biochemical influence of <i>Annona muricata</i> on the basal renal profile of healthy adult Wistar rats." Caliphate Journal of Science and Technology 5, no. 2 (2023): 239–45. http://dx.doi.org/10.4314/cajost.v5i2.20.

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Numerous ethnopharmacological benefits have been attributed to Annona muricata, including, wound healing, anti-arthritic, hypolipidemic, anti-inflammatory, anti-nociceptive, anti-hypertensive, hepatoprotective and antineoplastic effects. This study is a baseline investigation of the influence of A. muricata on renal profile of healthy adult Wistar rats. A total of 144 adult male Wistar rats of average weight (100 - 150 g) were randomly divided into six groups (1-6): Group 1 served as control (0 mg/kg), Groups 2, 3, 4, 5 and 6 were orally treated doses of methanol extracts of the leaf, stem-bar

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Oguekwe, OD, FN Oguwike, CM Nwozor, and NI Odikpo. "Comparative Study of the Effect of Aqueous Seed Extract of Tetracarpidium conophorum (Walnut) and Leaf Extract of Annona muricata (Soursop) on Calcium Level and the Lipid Profile of Male Wistar Rats." Greener Journal of Biomedical and Health Sciences 7, no. 1 (2024): 17–25. http://dx.doi.org/10.15580/gjbhs.2024.1.060624073.

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The study examined the lipid profile and calcium levels in male Wistar rats treated with Tetracarpidium conophorum and Annona muricata extracts. Twenty-Five (25) male Wistar rats weighing 150–170 g were randomly divided into five groups of five rats each. Groups A and B received 1000 and 500 mg/kg of aqueous seed extract of Tetracarpidium conophorum, respectively. Groups C and D received 1000 and 500 mg/kg aqueous leaf extracts of Annona muricata, respectively, and group E received feed and water only for 30 days. Data obtained for lipid profile (total cholesterol, low-density lipoprotein, hig

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Effect, of temperature on the morphology and cultural characteristics of Corynespora pathogen of cotton under South Gujarat of India. "Effect of temperature on the morphology and cultural characteristics of Corynespora pathogen of cotton under South Gujarat of India." Acta Biology Forum 02, no. 01 (2023): 10–17. https://doi.org/10.5281/zenodo.8077722.

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The present study investigated the protective effect of methanol leaf extract of Annona muricata (soursop) against bromate-induced kidney and liver damage in male albino Wistar rats. After acclimatization to laboratory conditions for 7 days, 36 rats were randomly and equally assigned to 6 groups. Five groups received bromate ion at a dose of 60 mg/kg body weight (bwt) via gavage. Bromateexposed rats in the negative control (group II) were untreated, while 3 groups of bromate-exposed rats (III, IV, and V) were coadministered graded doses of Annona muricata extract (200, 300, and 500 mg/kg bwt,

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Opara, P. O., V. H. A. Enemor, F. U. Eneh, and F. C. Emengaha. "Blood Glucose – Lowering Potentials of Annona muricata Leaf Extract in Alloxan–Induced Diabetic Rats." European Journal of Biology and Biotechnology 2, no. 2 (2021): 106–13. http://dx.doi.org/10.24018/ejbio.2021.2.2.178.

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The blood glucose- lowering potentials of ethanol leaf extract of Annona muricata were studied. Thirty wistar albino rats were divided into six groups of five rats per group. Group 1 served as “Normal control” animals and received normal rat pellets and water. Diabetes mellitus was induced in Groups 2, 3, 4, and 5 by intraperitoneal injection of alloxan (130 mg/kg). Group 6 rats were administered with 400 mg/kg daily of the extract without induction; group 3 rats were treated with glibenclamide (5 mg/kg body weight), groups 4 and 5 received 200 mg/kg and 400 mg/kg body weight of A. muricata le

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Shobande, Elizabeth, and Kolawole Ajiboye. "Anti-tumour and Anti-inflammatory Effects of Fractions of Annona muricata leaf-extract on dimethylbenzanthracene-induced mammary tumours in Wistar rats." CURRENT TRENDS IN LIFE SCIENCES RESEARCH 1, no. 2 (2022): 133–40. http://dx.doi.org/10.61867/pcub.v1i2b.038.

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The major challenge concerning tumours and cancers is that they currently do not have a cure. The side effects from the available treatment options have made research gravitate towards phytotherapy. Annona muricata is one of the highly recommended plants due to its usage albeit in crude form in treating several diseases especially, tumours and cancer inclusive. However, the fraction of its extracts responsible for these effects, is still unknown. This study was designed to investigate the anti-tumour and anti-inflammatory effects of Hexane, ethyl-acetate, butanol and aqueous fractions of A. mu

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Nonso, Ezeokafor Emmanuel, Nnaemeka Wuraola Serah Nnaemeka Wuraola Serah, Njidea Constance Uchefuna, et al. "The Effect of Ethanolic Soursop Leaf Extract on Caffeine-Induced Anxiety in Female Wistar Rats." International Journal of Research and Scientific Innovation XI, no. XII (2024): 195–204. https://doi.org/10.51244/ijrsi.2024.11120020.

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Soursop is a tropical fruit tree that has gained attention for its potential health benefits, which are attributed to its rich phytochemical composition, including flavonoids. The present study investigates the effects of ethanolic extracts of soursop (Annona muricata) leaves on caffeine-induced anxiety in female Wistar rats. Caffeine, a widely consumed psychoactive stimulant, is known to induce anxiety-like behaviors, which can negatively impact overall well-being (Hughes & Hancock, 2017). The anxiolytic potential of soursop leaves, traditionally used in herbal medicine, is explored in th

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Sánchez-De-La-Rosa, Susana Vanessa, Blanca Patricia Lazalde-Ramos, Gabriela Morales-Velazquez, et al. "Evaluation of Genotoxic Effect and Antigenotoxic Potential against DNA Damage of the Aqueous and Ethanolic Leaf Extracts of Annona muricata Using an In Vivo Erythrocyte Rodent Micronucleus Assay." BioMed Research International 2022 (December 16, 2022): 1–15. http://dx.doi.org/10.1155/2022/9554011.

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Annona muricata have been extensively used in traditional medicine to treat multiple diseases, including cancers. This study evaluated the genotoxic potential and antigenotoxic activities of A. muricata aqueous and ethanolic leaf extracts by employing an in vivo erythrocyte rodent micronucleus assay. Different doses (187.5, 375, and 750 mg/kg) of both extracts were administered orally for 5 days alone and combined with cyclophosphamide (CP, 60 mg/kg) to BALB/c mice. Also, it was administered orally to Wistar rats for 5 days through the final stage of gestation. No genotoxic or cytotoxic effect

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ADELEYE, O. E., N. A. ABOAJAH, A. I. ADELEYE, et al. "ANNONA MURICATA LINN. ETHANOLIC LEAF EXTRACT AMELIORATES REPRODUCTIVE COMPLICATIONS IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS." Journal of Natural Sciences Engineering and Technology 18, no. 1 (2020): 166–75. http://dx.doi.org/10.51406/jnset.v18i1.2040.

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Diabetes mellitus is an endocrine and metabolic disorder of humans and animals characterized by hyperglycemia and low blood insulin levels or insensitivity of target organs to insulin and it’s a major health problem affecting patient’s quality of life due to its many complications. Infertility is one of the major secondary complications in diabetes. Although numerous drugs have been used for intervention studies on diabetes-induced infertility worldwide, there are currently no treatments for diabetes associated infertility in humans. This study was performed to investigate the effects of Annon

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Esther Ifeyinwa Etu, Nyejirime Young Wike, Kenneth Eze Etu, et al. "Evaluation of varying doses of ethanol leave extract of senna occidentalis, annona muricata and aju-mbaise on liver biochemical parameters and hematological indices in Wistar rats." GSC Biological and Pharmaceutical Sciences 29, no. 3 (2024): 311–21. https://doi.org/10.30574/gscbps.2024.29.3.0471.

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Purpose of the Research: This research evaluated the effect of varying doses of ethanol extract leaves of Senna occidentalis, Annona muricata, and Aju-mbaise on the liver biochemical parameters and hematological indices in Wistar rats. Scope of the experiment: Twenty Wistar rats weighing 120 g to 150 g were used. They were distributed into four groups, with five rats each. Group one served as a control and was given water and normal rat chow. Groups 2, 3, and 4 were given S. occidentalis, A. muricata, and A. mbaise extracts for 30 days, respectively. At the end of the experiment, blood samples

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Esther, Ifeyinwa Etu, Young Wike Nyejirime, Eze Etu Kenneth, et al. "Evaluation of varying doses of ethanol leave extract of senna occidentalis, annona muricata and aju-mbaise on liver biochemical parameters and hematological indices in Wistar rats." GSC Biological and Pharmaceutical Sciences 29, no. 3 (2024): 311–21. https://doi.org/10.5281/zenodo.14915644.

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<strong>Purpose of the Research:</strong> This research evaluated the effect of varying doses of ethanol extract leaves of <em>Senna occidentalis</em>, <em>Annona muricata,</em> and <em>Aju-mbaise</em> on the liver biochemical parameters and hematological indices in Wistar rats. <strong>Scope of the experiment:</strong> Twenty Wistar rats weighing 120 g to 150 g were used. They were distributed into four groups, with five rats each. Group one served as a control and was given water and normal rat chow. Groups 2, 3, and 4 were given <em>S. occidentalis, A

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Elmas, Özlem, Havva Hande Keser Şahin, Emrah Keskin, and Özlem Apsar Başaran. "Radioprotective Effects of Annona Muricata Leaf Extract in the Spinal Cord." Medical Journal of Western Black Sea 8, no. 2 (2024): 168–76. http://dx.doi.org/10.29058/mjwbs.1359185.

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Objective: The spinal cord is often involved in radiotherapy to treat malignancies and is considered as one of the most critical dose-limiting organs. Histopathological changes of radiation-induced spinal cord injury include gliosis, demyelination, and necrosis in the white matter, as well as vascular changes in both white and gray matter. All aerial parts of Annona muricata (AM) are used in traditional medicine practices, and previous studies revealed that AM leaf extract has radioprotective effect against gamma- irradiation. This study aimed to evaluate the possible protective effect of AM l

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Astini, Dewa Ayu Agung Alit Suka, I. Wayan Putu Sutirta Yasa, I. Made Jawi, I. Nyoman Wande, Putu Indah Budi Apsari, and Luh Gde Evayanti. "The Effect of Ethanolic Extract of Annona muricata L. Leaves on Cerebellum Neurons in Noise-Exposed Adult Wistar Rats." Biomedical and Pharmacology Journal 17, no. 4 (2024): 2693–707. https://doi.org/10.13005/bpj/3059.

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Noise is an environmental condition that we encounter in everyday life. The level of noise varies in certain environments, such as work environments, traffic on highways, noise in cafeterias, and others. This exposure can affect the coordination system in our body, such as the cerebellum. Soursop leaf extract has been widely used in traditional medicine, the antioxidant content in this extract has many health benefits. Soursop leaf extract (Annona muricata L.) can be useful as an anti-inflammatory, providing protection to nerve cells from free radicals, and other benefits. This study aims to t

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ARO, Ehimigbai, Emma-Egbumokei O, and Ohirhian J. "Effects of aqueous leaf extract of soursop fruit (Annona muricata) on the kidney of adult wistar rats." Journal of Pharmacognosy and Phytochemistry 14, no. 3 (2025): 586–91. https://doi.org/10.22271/phyto.2025.v14.i3g.15412.

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Ekweaga, E. C., F. O. Tobalu, A. R. Orheruata, O. I. Momodu, O. U. Idemudia, and A. B. Enogieru. "Preliminary Evidence Of Possible Neurotoxic Activity Of Aqueous Annona muricata (Soursop) Leaf Extract In The Cerebellum Of Adult Wistar Rats." Journal of Applied Sciences and Environmental Management 29, no. 2 (2025): 393–400. https://doi.org/10.4314/jasem.v29i2.7.

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Global trends show a rising adoption of plant-based diets due to their therapeutic benefits, however, studies show that some medicinal plants may induce neurotoxicity. Accordingly, this study investigated the preliminary evidence of possible neurotoxic activity of aqueous Annona muricata (Soursop) leaf extract (AMLE) on the cerebellum of adult Wistar rats using appropriate standard procedures after the cerebella were assayed for antioxidant enzymes activity, lipid peroxidation and histological changes. Findings revealed no significant difference (p>0.05) in the body, brain, cerebellar, rela

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Elmas, Ozlem, Havva Hande Keser Sahin, Berrak Guven, et al. "A focusing study on radioprotective and antioxidant effects of Annona muricata leaf extract in the circulation and liver tissue: Clinical and experimental studies." Open Chemistry 20, no. 1 (2022): 920–28. http://dx.doi.org/10.1515/chem-2022-0206.

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Abstract Objectives This study investigates the effect of Annona muricata (AM) leaf extract against irradiation-induced damage by the evaluation of hepatic tissue and the levels of oxidative and inflammatory stress in the circulation. Methods An experimental study with 37 female Wistar albino rats randomized into four groups (controls and three intervention groups) was performed. The first interventional group (group 2) received 300 mg/kg of AM leaf extract by oral gavage once a day for 9 days, group 3 received a single dose of whole-body radiation (8.3 Gy) after a 9-day oral gavage treatment

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Odera, Sarah King Chinwuko, and Lasbrey Asomugha Azuoma. "The impact of administration of Annona muricata leaf on estrogen and progesterone functions following mercury-induced toxicity in adult female Wistar rats." World Journal of Advanced Research and Reviews 21, no. 2 (2024): 1277–82. https://doi.org/10.5281/zenodo.14028113.

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Environmental toxicants have been linked to female reproductive dysfunction resulting from oxidative stress. The study assesses the impact of ethanolic leaf extract of <em>Annona muricata</em> (EAM) on ovarian and uterine function following mercury-induced toxicity in female Wistar rats. The study involved 40 female Wistar rats, each weighing 114–156g, divided into eight groups of five animals each. Group A received feed and water only; group B received 500 mg/kg of EAM only; and group C received 25 mg/kg of mercury chloride (HgCl<sub>2</sub>). Groups D and E received 100 mg/kg

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Odera, Sarah King Chinwuko, and Lasbrey Asomugha Azuoma. "The Impact of administration of Annona muricata leaf on estrogen and progesterone functions following mercury-induced toxicity in adult female Wistar rats." World Journal of Advanced Research and Reviews 21, no. 2 (2024): 1357–63. https://doi.org/10.5281/zenodo.14029072.

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Environmental toxicants have been linked to female reproductive dysfunction resulting from oxidative stress. The study assesses the impact of ethanolic leaf extract of <em>Annona muricata</em> (EAM) on ovarian and uterine function following mercury-induced toxicity in female Wistar rats. The study involved 40 female Wistar rats, each weighing 114–156g, divided into eight groups of five animals each. Group A received feed and water only; group B received 500 mg/kg of EAM only; and group C received 25 mg/kg of mercury chloride (HgCl<sub>2</sub>). Groups D and E received 100 mg/kg

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Gbenga, Ojuolape, Muhammed Ola, Ajayi Samuel, and Afodun Adam. "Histochemical Evaluation of Some of the Effects of Annona muricata Leaf Extract on Dermatophytosis in Wistar Rats: A Pilot Study." Journal of Advances in Medical and Pharmaceutical Sciences 8, no. 3 (2016): 1–9. http://dx.doi.org/10.9734/jamps/2016/26247.

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Nai, Tika Hamidah Apriliana, Retno Yulianti, Wahyunia Likhayati Septiana, and Yuni Setyaningsih. "COMPARISON OF THE EFFECTIVENESS OF PHYSICAL TRAINING AND EXTRACT OF SOURSOP LEAF TO HISTOPATHOLOGY OF ABDOMINAL AORTA FOAM CELLS IN HIPERCOLESTEROLEMIA-DIABETES RAT." Acta Biochimica Indonesiana 3, no. 1 (2020): 37–50. http://dx.doi.org/10.32889/actabioina.v3i1.48.

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Background: Diabetes mellitus has become a public health problem globally. Type 2 diabetes mellitus, caused by lifestyle and high lipid diet, is the most common form. Hypercholesterolemia-diabetes is able to create endothelial injury that results in formation of atherosclerosis, starting with formation of foam cells. Objective: This research aimed to see the effectiveness of physical training and soursop (Annona muricata) leaves extract in lowering the amount of foam cells.Methods: This research was an experimental study which used the post test-only control group design with 35 Wistar strain

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Odera Sarah King Chinwuko and Azuoma Lasbrey Asomugha. "The Impact of administration of Annona muricata leaf on estrogen and progesterone functions following mercury-induced toxicity in adult female Wistar rats." World Journal of Advanced Research and Reviews 21, no. 2 (2024): 1357–63. http://dx.doi.org/10.30574/wjarr.2024.21.2.0545.

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Environmental toxicants have been linked to female reproductive dysfunction resulting from oxidative stress. The study assesses the impact of ethanolic leaf extract of Annona muricata (EAM) on ovarian and uterine function following mercury-induced toxicity in female Wistar rats. The study involved 40 female Wistar rats, each weighing 114–156g, divided into eight groups of five animals each. Group A received feed and water only; group B received 500 mg/kg of EAM only; and group C received 25 mg/kg of mercury chloride (HgCl2). Groups D and E received 100 mg/kg and 500 mg/kg of EAM for 4 weeks an

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SETON, Santorin, Omédine KOUKOUI, Jean Baptiste AMAGBEGNON, et al. "Toxicological and anti-hyperglycemic studies of five plants used for the treatment of type 2 diabetes in Benin." Journal of Drug Delivery and Therapeutics 12, no. 5-S (2022): 47–53. http://dx.doi.org/10.22270/jddt.v12i5-s.5629.

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In Benin as in the African sub-region, the burden of Non-Communicable Diseases (NCDs) and the threats they represent constitute a major public health problem which hinders their economic and social development. NCDs kill 36 million people each year and 80% of deaths occur in developing countries, including Benin. The objective of our work is to evaluate the acute, subacute toxicity and the anti-hyperglycemic activity of five plants listed through an ethno pharmacological survey which is used for the treatment of type 2 diabetes in Benin. The acute toxicity test was conducted on male and female

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Ibezute, Albert, Sese-Owei Ekaye, and Fortune Adike. "Comparative Analysis of the Chemo-therapeutic Potential of Dialium guineense (Wild) and Annona muricata L. Leaf Extract on Dumpsite Leachate Induced Hepatoxicity in Wistar Rats." Asian Journal of Biology 5, no. 3 (2018): 1–8. http://dx.doi.org/10.9734/ajob/2018/35887.

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Prabowo, Erik, Neni Susilaningsih, Catharina Suharti, et al. "Anticancer effects of soursop leaf extract as a supplement to standard sorafenib therapy: An apoptosis pathway study in a rat model of hepatocellular carcinoma." Electronic Journal of General Medicine 22, no. 4 (2025): em670. https://doi.org/10.29333/ejgm/16568.

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<b>Background:</b> Hepatocellular carcinoma (HCC), the most common primary liver cancer, remains a leading cause of cancer-related deaths worldwide, particularly in regions with a high prevalence of chronic liver diseases. Its increasing incidence is driven by rising rates of cirrhosis due to viral hepatitis, alcohol abuse, and non-alcoholic fatty liver disease. Despite advancements, HCC is often diagnosed at advanced stages, limiting curative treatment options. Sorafenib, a tyrosine kinase inhibitor, is the standard treatment for advanced HCC, but its modest efficacy and significa

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Natacha, Aivodji, Ahokpe Melanie, Justin Behanzin, and Sezan Alphonse. "Evaluation of the toxicity of Annona muricata leaf extracts on liver and kidney function and investigation of acute and subacute toxicity in Wistar rats." American Journal of PharmTech Research 8, no. 1 (2018): 189–217. http://dx.doi.org/10.46624/ajptr.2018.v8.i1.013.

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Adeoye, Ayodeji David, Kosisochukwu Angel Amadike, Bayo Olufunso Adeoye, Oyetola Tolulope Oyebanjo, and Lola Adeola Adelakin. "Effect of Ethanol Extract of Annona muricata on Lipopolysaccharide Induced Neuroinflammation in Wistar Rats." Scholars International Journal of Anatomy and Physiology 6, no. 10 (2023): 153–61. http://dx.doi.org/10.36348/sijap.2023.v06i10.002.

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Introduction: Annona muricata is a lowland tropical fruit bearing tree of the Annonaceae family which can be found in the rainforest of Africa, South America, and Southeast Asia. It is commonly known as soursop, graviola, guanabana, or brazillian pawpaw. It has a large, glossy, dark green leaves with edible, green heart-shaped fruit. The leathery skin of the fruit is covered with soft, curved spines each of which may contain 55-170 black seeds distributed in a creamy white flesh with a characteristic aroma and flavour. Objectives: The study aims to investigate the effect of ethanol extract of

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Ehiremen, S. E., G. I. Iyare, and N. T. Omorodion. "Restorative effect of <i>Annona muricataextract</i> on histomorphology of testicular tissue of cadmium tumor induced albino rats." Journal of Health, Applied Sciences and Management 7, no. 2 (2024): 66–80. http://dx.doi.org/10.4314/johasam.v7i2.6.

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Cadmium is a harmful heavy metal that is widely distributed in the environment. This study aimed to investigate the effects of Annona muricata seed extract on cadmium-induced testicular toxicity in adult male Wistar rats. A total of 35 adult male Wistar rats were randomly divided into five groups (A–E)) of 7 rats each. Group A (the control group) received distilled water only; group B-E received 2 mg/kg of cadmium (S.C.) and 100 mg/kg body weight of Annona muricata, 2 mg/kg of cadmium (S.C.) and 200 mg/kg body weight of Annona muricata, and 2 mg/kg of cadmium and 300 mg/kg body weight of Annon

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Fakunle P. B., Ehiremen Samuel, Odubela Kayode, and Bamgbose Kehinde. "Assessment of Protective Roles of Aqueous Seed Extract of Sour-Sop (Annona muricata) in Cerebellum Following Cadmium-induced Neurotoxicity of Adult Wistar Rats." Asian Journal of Research in Medical and Pharmaceutical Sciences 13, no. 1 (2024): 9–20. http://dx.doi.org/10.9734/ajrimps/2024/v13i1243.

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Cadmium, a deleterious heavy metal that pervades the environment, has the potential to accumulate in the body and cause health complications. In the domain of traditional medicine, medicinal plants have been employed to combat the toxicity of heavy metals and treating of many diseases in traditional medicine. Aim: To access the protective impact of Annona muricata seed extract on cadmium-triggered neurotoxicity in the cerebellum of albino wistarrat. Place of Study: Department of Anatomy, Faculty of Basic Medical Sciences Olabisi Onabanjo University, Ogun State between June 2022 and

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Adeyemo, Racheal O., Chukwugozie N. Okwuosa, Abraham O. Asuku, Michael B. Adeyemo, and Sodiq A. Agoro. "Biochemical and Toxicological Evaluation of Stem Bark Extract of Annona muricata in Male Wistar Rat." INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH 7, no. 2 (2022): 1–8. http://dx.doi.org/10.56201/ijhpr.v7.no2.2022.pg1.8.

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This study was designed to evaluate the biochemical and toxicological properties of stem bark extract of Annona muricata in twelve (12) male Wistar rats, weighing 190-220g. The rats were grouped into three (3), A-C. Group A served as normal control while groups B and C were given different graded doses of methanol extract of Annona muricata (MEAM) stem bark orally (1000mg/kg and 2000mg/kg respectively) at once daily for 21 days. 5mls of blood were collected aseptically for the determination of alanine transaminase (ALT), aspartate transaminase (AST), total white blood cell counts (TWBCC), pack

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