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Journal articles on the topic 'Antacids'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ramadan, Mai, and Saba Turk. "Assessment of the Acid Neutralizing Capacity and Other Properties of Antacid Formulations Marketed in the Gaza Strip." Israa University Journal for Applied Science 6, no. 2 (2023): 97–110. http://dx.doi.org/10.52865/qchr1551.

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Background: Antacids are frequently used as over-the-counter (OTC) medications to reduce symptoms of dyspepsia and to neutralize stomach acidity. Evaluation of antacids efficacy depends on in vitro testing like acid neutralizing capacity (ANC) and acid neutralization potential (ANP). The purpose of this study was to examine ANC, ANP, and other characteristics of commercially available antacid formulations (both liquid and solid formulations) in the Gaza Strip. Methods: Both liquid (n=2) and solid (n=4) antacid formulations were acquired from the Gaza Strip’s central community pharmacies. Preli

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2

Sutphen, James L., Vivian L. Dillard, and Mary E. Pipan. "Antacid and Formula Effects on Gastric Acidity in Infants With Gastroesophageal Reflux." Pediatrics 78, no. 1 (1986): 55–57. http://dx.doi.org/10.1542/peds.78.1.55.

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A variety of peptic diseases are treated with antacids. Antacid dose requirements for young children have not been extensively evaluated. Moreover, the effects of formula feedings on antacid requirements are also unknown. We have investigated the effects of antacids and formula feedings on gastric acidity in infants less than 1 year of age. Small formula feedings of 15 mL/kg per feeding significantly improve antacid buffering of 0.5 mL/kg per dose of standard magnesium-aluminum hydroxide antacids.

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3

Garg, Vandana, Prashant Narang, and Ritu Taneja. "Antacids revisited: review on contemporary facts and relevance for self-management." Journal of International Medical Research 50, no. 3 (2022): 030006052210864. http://dx.doi.org/10.1177/03000605221086457.

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Heartburn and acid regurgitation are the typical symptoms of gastroesophageal reflux. Despite the availability of several treatment options, antacids remain the mainstay treatment for gastroesophageal reflux-related symptoms based on their efficacy, safety, and over-the-counter availability. Antacids are generally recommended for adults and children at least 12 years old, and the FDA recommends antacids as the first-line treatment for heartburn in pregnancy. This narrative review summarizes the mechanism, features, and limitations related to different antacid ingredients and techniques availab

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DEB, SIDDHARTHA. "Antacid Poisoning." Pediatrics 86, no. 2 (1990): 325. http://dx.doi.org/10.1542/peds.86.2.325.

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To the Editor.— Dr J. Brand and Dr F. Greer's discussion of a case of hypermagnesemia and intestinal perforation following antacid administration in a premature infant1 can be misleading to physicians who may need to use antacids for treating their patients. The patient in consideration was receiving 18 mL/kg/d of antacids. This is equivalent to more than a liter of antacids per day for an average adult weighing 60 kg. The management of bleeding of the upper gastrointestinal tract would include the use of H2 receptor blocking agents and usually 2 to 4 mL of antacids or more per kg per day to k

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5

Boya, Dina, and Jwan Ahmed. "Comparison of Acid-neutralizing capacity of antacids in Erbil City." Zanco Journal of Medical Sciences 25, no. 2 (2021): 586–90. http://dx.doi.org/10.15218/zjms.2021.023.

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Background and objective: Antacids are basic substances that can neutralize hydrochloric acid and reduce gastric acidity. They are over the counter drugs used to treat dyspepsia. The most commonly used antacids are sodium bicarbonate, magnesium hydroxide, aluminum hydroxide, and calcium carbonate. This study aimed to evaluate the effectiveness of antacids that are commonly used in Erbil city by finding their acid-neutralizing capacity. Methods: The method for acid-neutralizing capacity was adapted from pharmacopeia. The samples were prepared by dissolving the antacid in an excess amount of hyd

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6

Parakh, Rajendra Kumar, and Neelakanth S. Patil. "Anaesthetic antacids: a review of its pharmacological properties and therapeutic efficacy." International Journal of Research in Medical Sciences 6, no. 2 (2018): 383. http://dx.doi.org/10.18203/2320-6012.ijrms20180005.

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Anaesthetic antacids, combination of antacids (Aluminium hydroxide, Magnesium hydroxide) with an anaesthetic (oxethazaine), is becoming a choice of physicians and is re-emerging across all types of GI disorders (esophagitis, peptic ulcer, duodenal ulcer, heartburn, gastritis, functional dyspepsia), despite the discovery of potent and efficacious acid suppressants like H2 receptor blockers and proton pump inhibitors (PPIs). The reason being that anaesthetic antacids increase the gastric pH and provide relief from pain for a longer period of duration at considerably a lower dosage. Furthermore,

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7

Watts, D. W. "In Vitro Buffering Capacities of Proprietary Non-Particulate Antacids Available in New Zealand." Anaesthesia and Intensive Care 22, no. 2 (1994): 184–86. http://dx.doi.org/10.1177/0310057x9402200212.

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Four commercially available non-particulate antacid preparations were titrated against 1M hydrochloric acid to assess buffering capacity as compared to 30 ml 0.3M sodium citrate solution. All antacids were used in the manufacturers “unit dose”. All antacids tested demonstrated some in vitro buffering capacity, and “Eno” (Reckitt and Colman) had a buffering capacity similar to that of sodium citrate. The retail cost per unit dose was established for each proprietary antacid and for sodium citrate. It was concluded that while proprietary antacids are cheaper per dose than sodium citrate, prepara

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8

Benjamin U Ebeshi, Samuel J Bunu, Hilda F Kpun, and Cynthia O Ezebube. "Analysis of gastrointestinal acid-neutralizing potency of some commercial antacid tablet formulations." GSC Biological and Pharmaceutical Sciences 19, no. 2 (2022): 008–13. http://dx.doi.org/10.30574/gscbps.2022.19.2.0159.

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In dyspepsia, formulations known as antacids are regularly used to alleviate symptoms as quickly as possible. Gastric contents are acidic; therefore, antacids are usually weak bases with the potential to neutralize excess acid and raise gastric pH accordingly. Acid-neutralizing capacity is what determines the effectiveness of an antacid. Some antacid tablets formulation from different manufacturers were tested for their acid-neutralizing capacity and effectiveness for patients in this study. The South-East region of Nigeria had pharmacies vending antacids of different brands. To remove potenti

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9

Benjamin, U. Ebeshi, J. Bunu Samuel, F. Kpun Hilda, and O. Ezebube Cynthia. "Analysis of gastrointestinal acid-neutralizing potency of some commercial antacid tablet formulations." GSC Biological and Pharmaceutical Sciences 19, no. 2 (2022): 008–13. https://doi.org/10.5281/zenodo.6627324.

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In dyspepsia, formulations known as antacids are regularly used to alleviate symptoms as quickly as possible. Gastric contents are acidic; therefore, antacids are usually weak bases with the potential to neutralize excess acid and raise gastric pH accordingly. Acid-neutralizing capacity is what determines the effectiveness of an antacid. Some antacid tablets formulation from different manufacturers were tested for their acid-neutralizing capacity and effectiveness for patients in this study. The South-East region of Nigeria had pharmacies vending antacids of different brands. To remove potenti

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10

Plotnikova, E. Y., and L. G. Vologzhanina. "Antacids and their role in treatment of digestive diseases in pregnant women." Herald of Pancreatic Club 47, no. 2 (2020): 82–88. http://dx.doi.org/10.33149/vkp.2020.02.10.

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Antacids are drugs that can neutralize or buffer the hydrochloric acid of the stomach without affecting its production. History of the clinical use of antacids dates back several centuries. The article discusses the advantages and disadvantages of modern antacids, provides a classification of drugs of this group, considers the mechanisms of their action, explains the term “acid-neutralizing activity”, lists indications for the use of antacids and possible adverse effects of antacid therapy. The results of various foreign and domestic studies on the use of acid-suppressive drugs, including anta

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11

Okhuelegbe, Eraga Sylvester, Idemili Nwachukwu Osita, and Iwuagwu Magnus Amara. "In vitro interaction between Zidovudine and some adsorptive antacids." Dhaka University Journal of Pharmaceutical Sciences 13, no. 1 (2015): 1–6. http://dx.doi.org/10.3329/dujps.v13i1.21853.

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The in vitro interaction between zidovudine and three antacids and a commercial product was investigated. The extent of adsorption of zidovudine by the antacids, and the effects of the antacids on the disintegration time and dissolution of the drug from tablets were studied. Adsorption of the drug by the antacids followed the order; magnesium trisilicate > aluminium hydroxide > magnesium hydroxide. Retardation of dissolution amongst the antacids and commercial product was of the order; Jawasil® > magnesium trisilicate > aluminium hydroxide > magnesium hydroxide. Also, the degree

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12

Grunder, Gabriela, Yvonne Zysset-Aschmann, Florence Vollenweider, Thomas Maier, Stephan Krähenbühl, and Juergen Drewe. "Lack of Pharmacokinetic Interaction between Linezolid and Antacid in Healthy Volunteers." Antimicrobial Agents and Chemotherapy 50, no. 1 (2006): 68–72. http://dx.doi.org/10.1128/aac.50.1.68-72.2006.

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ABSTRACT Several antibiotics show significant pharmacokinetic interactions when they are given orally concomitantly with antacids. The objective of this study was to evaluate the effects of antacid (containing magnesium) on the pharmacokinetics of linezolid. A single dose of 600 mg linezolid was given orally alone and 10 min after administration of the antacid Maalox 70mVal, which contains 600 mg magnesium hydroxide and 900 mg aluminum hydroxide, to nine healthy males and nine healthy females in a crossover and randomized study. Linezolid plasma concentrations were determined by high-performan

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13

Dhawal, Pranjali P., and Siddhivinayak S. Barve. "Preliminary in-vitro evaluation of marketed formulations for antacid activity." International Journal of Basic & Clinical Pharmacology 9, no. 1 (2019): 57. http://dx.doi.org/10.18203/2319-2003.ijbcp20195764.

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Background: Hydrochloric acid (pH 1.5-3.5) being the major component of gastric acid is produced by parietal cells of stomach. Its secretion is a complex and relatively energetically expensive process. The preservation of acidity of stomach is evidently important because of its implications in peptic and duodenal ulceration.Methods: In the present study, we attempted to compare the activity of 13 (F1-F13) antacid formulations (5-liquid, 4- quick releases and 4- tablets) by using acid-base neutralization studies. Preliminary antacid test (PAT) was performed to define whether the given formulati

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14

Tsou, V. Marc, Rose M. Young, Michael H. Hart, and Jon A. Vanderhoof. "Elevated Plasma Aluminum Levels in Normal Infants Receiving Antacids Containing Aluminum." Pediatrics 87, no. 2 (1991): 148–51. http://dx.doi.org/10.1542/peds.87.2.148.

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Aluminum toxicity is a documented cause of encephalopathy, anemia, and osteomalacia. Excretion is primarily renal; therefore, patients with renal insufficiency are at risk for aluminum accumulation and toxicity. This has been demonstrated in uremic children treated with aluminum-containing antacids. The purpose of this study was to determine whether plasma aluminum levels were elevated in infants with normal renal function during prolonged aluminum-containing antacid use. Ten study infants (mean age = 5.8 months), who had been receiving antacids for at least 1 week, were compared with 16 contr

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15

Shinde, Ujwala A., Nisha S. Sharma, Pradnya R. Petkar, et al. "In vitro evaluation of raft-forming and non-raft forming antacids marketed in India." International Journal of Research in Medical Sciences 13, no. 4 (2025): 1488–94. https://doi.org/10.18203/2320-6012.ijrms20250970.

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Background: Raft properties of alginate‐antacids may vary based on their formulation. This study compared the physicochemical characteristics such as raft properties of Digeraft Plus® versus four other raft-forming (brands A to D) and acid neutralizing properties of raft-forming antacids versus two non-raft forming (brands E, F) antacids marketed in India. Methods: The study assessed acid neutralizing capacity (ANC), and acid neutralizing potential (ANP) of the raft and non-raft forming antacids and the effect of raft structure on neutralization profile, raft strength, and raft resilience of t

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16

Lazarević, Slavica, Srđan Kosijer, Maja Đanić, et al. "In Vitro Evaluation of Drug–Drug Interaction Between Gliclazide and Antacids at the Absorption Level." Pharmaceuticals 18, no. 5 (2025): 684. https://doi.org/10.3390/ph18050684.

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Background: The antidiabetic drug gliclazide is often taken with antacids due to its gastrointestinal side effects. However, patients rarely report antacid use, making drug–drug interactions a potential cause of therapy failure. Therefore, this study aimed to investigate the in vitro effects of various antacids on gliclazide permeability and to explore the underlying mechanisms. Methods: The permeability of gliclazide alone and in the presence of antacids (sodium bicarbonate, calcium carbonate, aluminum hydroxide, hydrotalcite and calcium carbonate/magnesium carbonate) was investigated using t

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17

Savla, Hemali M., Isha V. Naik, Chandrashekhar Gargote, Nischal Shashidhar, Sneha Nair, and Mala D. Menon. "Physicochemical properties of various alginate-based raft-forming antacid products: a comparative study." International Journal of Basic & Clinical Pharmacology 10, no. 12 (2021): 1330. http://dx.doi.org/10.18203/2319-2003.ijbcp20214449.

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Background: Alginate-based, raft-forming antacid products with reflux suppressant activity are complex formulations expected to achieve effective raft formation and cause elimination or displacement of the acid pocket, which is typically manifested in gastroesophageal reflux disease (GERD).Methods: In the present study, six alginate-based raft-forming products commercially available in the Indian market were compared in terms of their acid neutralization properties, strength, resilience and structural and thermal properties of their rafts. Percent alginate content was also determined.Results:

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18

Uzunović, Alija, and Edina Vranić. "Influence of Type and Neutralisation Capacity of Antacids on Dissolution Rate of Ciprofloxacin and Moxifloxacin from Tablets." Bosnian Journal of Basic Medical Sciences 9, no. 1 (2009): 89–93. http://dx.doi.org/10.17305/bjbms.2009.2864.

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Dissolution rate of two fluoroquinolone antibiotics (ciprofloxacin and moxifloxacin) was analysed in presence/absence of three antacid formulations. Disintegration time and neutralisation capacity of antacid tablets were also checked. Variation in disintegration time indicated the importance of this parameter, and allowed evaluation of the influence of postponed antacid-fluoroquinolone contact. The results obtained in this study showed decreased dissolution rate of fluoroquinolone antibiotics from tablets in simultaneous presence of antacids, regardless of their type and neutralisation capacit

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19

D'arcy, P. F., and James C. Mcelnay. "Drug-Antacid Interactions: Assessment of Clinical Importance." Drug Intelligence & Clinical Pharmacy 21, no. 7-8 (1987): 607–17. http://dx.doi.org/10.1177/1060028087021007-806.

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Antacids and adsorbents are commonly used preparations that are generally considered to be pharmacologically inert and free from adverse effects. They may, however, interact with a diverse range of primary drugs and the sequelae can be disadvantageous to the efficacy of the primary medication. Many such reports in the literature are based on animal experiments, or on single-dose studies in healthy subjects. Some reports are anecdotal and are unconfirmed; others are based solely on in vitro evidence. Potentially important interactions have been suggested for a relatively small group of drugs: t

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20

Mostoufi, Azar, Neda Bavarsad, Sahar Aryanfar, and Abbas Akhgari. "New Natural Marine Antacid Drug from Cuttlebone." Pharmaceutical Sciences 24, no. 3 (2018): 227–34. http://dx.doi.org/10.15171/ps.2018.33.

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Background: Antacids are the most commonly used medications for fast symptomatic relief of gastric disorders. Because of adverse effects, low efficiency and the high cost of some chemical antacids, identifying a natural medicine with high efficiency and low cost seems useful. Therefore, the aim of the present study was to prepare antacid tablets from Cuttlefish bone and assessment of its antacid properties. Methods: 24 different formulations of cuttlefish bone were prepared by direct compression using different fillers (starch, cellulose, lactose, and mixture of those) in different ratios of t

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21

Trukhan, D. I., E. N. Degovtsov, and A. Yu Novikov. "Antacids in real clinical practice." Meditsinskiy sovet = Medical Council, no. 8 (May 19, 2023): 59–67. http://dx.doi.org/10.21518/ms2023-141.

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Currently, proton pump inhibitors (PPIs), H2-histamine receptor blockers (H2-blockers), antacids, and anticholinergics are used to treat acid-dependent diseases of the gastrointestinal tract. PPIs are considered the most effective drugs for the treatment of acid-dependent diseases of the gastrointestinal tract. However, in real clinical practice, interest remains in the use of antacids in acid-dependent diseases. This is due to the fact that antacids not only adsorb hydrochloric acid in the gastric lumen (by buffering the HCl present in the stomach, without a significant effect on its producti

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Ogilvie, A. L., and Michael Atkinson. "Does Dimethicone Increase the Efficacy of Antacids in the Treatment of Reflux Oesophagitis?" Journal of the Royal Society of Medicine 79, no. 10 (1986): 584–87. http://dx.doi.org/10.1177/014107688607901009.

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Dimethicone is a common additive to antacids, although its value in the treatment of reflux oesophagitis is unproven. Its efficacy was assessed by comparing the effect of a dimethicone-containing antacid gel (Asilone Gel) with a simple antacid gel in a double-blind trial in 45 patients with reflux oesophagitis. Thirty-eight patients completed the eight-week course of therapy. Antacid therapy alone resulted in a significant improvement of both symptoms and oesophagitis in gastro-oesophageal reflux. The inclusion of dimethicone in the antacid gel preparation did not confer any benefit in terms o

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&NA;. "Antacids." Reactions Weekly &NA;, no. 544 (1995): 4. http://dx.doi.org/10.2165/00128415-199505440-00007.

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Ching, Chi-Kong, and Shiu-Kum Lam. "Antacids." Drugs 47, no. 2 (1994): 305–17. http://dx.doi.org/10.2165/00003495-199447020-00006.

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&NA;. "Antacids." Reactions Weekly &NA;, no. 629 (1996): 6. http://dx.doi.org/10.2165/00128415-199606290-00015.

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&NA;. "Antacids." Reactions Weekly &NA;, no. 865 (2001): 6–7. http://dx.doi.org/10.2165/00128415-200108650-00016.

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&NA;. "Antacids." Reactions Weekly &NA;, no. 878 (2001): 6. http://dx.doi.org/10.2165/00128415-200108780-00015.

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&NA;. "Antacids." Reactions Weekly &NA;, no. 1229 (2008): 4–5. http://dx.doi.org/10.2165/00128415-200812290-00009.

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&NA;. "Antacids." Reactions Weekly &NA;, no. 286 (1990): 4. http://dx.doi.org/10.2165/00128415-199002860-00005.

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&NA;. "Antacids." Reactions Weekly &NA;, no. 342 (1991): 4. http://dx.doi.org/10.2165/00128415-199103420-00007.

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&NA;. "Antacids." Reactions Weekly &NA;, no. 482 (1993): 6. http://dx.doi.org/10.2165/00128415-199304820-00020.

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BRAND, JOSEPH M., and FRANK R. GREER. "Hypermagnesemia and Intestinal Perforation Following Antacid Administration in a Premature Infant." Pediatrics 85, no. 1 (1990): 121–24. http://dx.doi.org/10.1542/peds.85.1.121.

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Antacid therapy is widely used prophylactically in pediatric intensive care units to prevent stress ulcers. It has also been used in the medical management of gastric bleeding in newborn infants.1,2 Complications of antacid therapy in the newborn infant have included hypotonia, asymptomatic hypermagnesemia without hypocalcemia, as well as aluminum-hydroxide bezoar formation.1-3 This is the first report in which a severe degree of these complications of magnesium-containing antacids is described that includes hypermagnesemia with hypocalcemia and in which a strong case is made against the use o

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Herman, Herman, and Sulfiyana H. Ambo Lau. "Level of public knowledge on the principle of DAGUSIBU in antacid drugs at thalhah pharmacy." Jurnal Ilmiah Kesehatan Sandi Husada 14, no. 1 (2025): 123–32. https://doi.org/10.35816/jiskh.v14i1.1260.

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Introduction: Antacids are commonly used over-the-counter medications for treating gastritis, yet public knowledge regarding their proper use remains limited. The DAGUSIBU (Obtain, Use, Store, Dispose) campaign by the Indonesian Pharmacists Association aims to improve rational drug use among the community. However, initial observation at Thalhah Pharmacy in Makassar revealed a lack of counseling related to DAGUSIBU principles. This study aims to assess the level of public knowledge regarding the DAGUSIBU principles related to antacid use at Thalhah Pharmacy. Method: This was a descriptive stud

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Auclair, Barbara, David E. Nix, Rodney D. Adam, Gordon T. James, and Charles A. Peloquin. "Pharmacokinetics of Ethionamide Administered under Fasting Conditions or with Orange Juice, Food, or Antacids." Antimicrobial Agents and Chemotherapy 45, no. 3 (2001): 810–14. http://dx.doi.org/10.1128/aac.45.3.810-814.2001.

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ABSTRACT This study was conducted in order to (i) determine the effect of food, orange juice, or antacids on the absorption of a single oral 500-mg dose of ethionamide (ETA) in healthy volunteers, including an assessment of bioequivalence, and (ii) determine ETA population pharmacokinetic (PK) parameters. The pharmacokinetics of ETA in serum was determined for 12 healthy males and females in a randomized, four-period crossover study. Volunteers received single 500-mg doses of ETA either on an empty stomach (reference) or with food, orange juice, or antacids. Serum samples were collected for 48

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Yulian, Agung, Beta Ria Yunita, Desti Nadia, et al. "Analysis of antacid tablets using the alkalimetric titration method." Asian Journal of Analytical Chemistry 1, no. 1 (2023): 25–31. http://dx.doi.org/10.53866/ajac.v1i1.284.

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Titrimetry is a quantitative analysis concerned with measuring the volume of a solution of known concentration required to react with the substance to be determined. On the other hand, alkalimetry determines the levels of acidic compounds that are reacted with essential standard solutions. Antacids can treat stomach disorders resulting from excess stomach acid production. The active ingredient is a mixture of magnesium hydroxide and aluminum hydroxide which is a weak base that reacts with acids. This study aims to determine whether the levels of antacid tablets in several pharmacies in Bandar

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Priyoherianto, Andri, Erna Fitriany, Deny Budi Legowo, and Sih Wahyuni Raharjeng. "Non-Medical Students Knowledge at Universitas Pesantren Tinggi Darul Ulum Jombang among the Use of Antacids From May to June 2023." Journal Pharmasci (Journal of Pharmacy and Science) 9, no. 1 (2024): 79–86. https://doi.org/10.53342/pharmasci.v9i1.353.

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ABSTRACT Antacids are stomach acid neutralizing drugs that are efficacious for relieving stomach ulcer pain. It is a gastric pain medicine or gastritis which is quite easy to get by every individual. This study aims to describe the knowledge of the use of antacid drugs in non-health students. Conducted at the Faculty of Teacher Training and Education, Mathematics Study Program, Pesantren Tinggi Darul Ulum University, Jombang. This research is a quantitative research with descriptive method. The data was obtained using an instrument in the form of a questionnaire sheet with a sample of 59 stude

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Aghayere, G. E., H. A. Okeri, and H. O. Abanum. "Comparative Assessment of the Acid-Neutralizing Capacity, Price and selected Physical Properties of different Antacids Suspensions available in Benin City, Edo State, Nigeria." Journal of Basic and Social Pharmacy Research 2, no. 4 (2022): 11–21. http://dx.doi.org/10.52968/27451777.

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Background: Patients are often faced with the challenge of choosing an antacids suspension that will provide effective and prompt relief from excessive gastric acid secretion. Objective: The aim was to evaluate acid-neutralizing capacity (ANC), price and selected physical properties of twenty (20) brands of antacids suspensions from pharmacies in Benin metropolis, Nigeria. Materials and Methods: United States Pharmacopeia assay method was used to determine the ANC. Visual inspection, pH, relative density and flow times were determined using standard methods. Results: The ANC of all the brands

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&NA;. "Antacids interaction." Reactions Weekly &NA;, no. 443 (1993): 5. http://dx.doi.org/10.2165/00128415-199304430-00009.

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&NA;. "Antacids/sucralfate." Reactions Weekly &NA;, no. 446 (1993): 5. http://dx.doi.org/10.2165/00128415-199304460-00012.

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Maton, Paul N., and Michael E. Burton. "Antacids Revisited." Drugs 57, no. 6 (1999): 855–70. http://dx.doi.org/10.2165/00003495-199957060-00003.

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&NA;. "Antacids abuse." Reactions Weekly &NA;, no. 341 (1991): 3. http://dx.doi.org/10.2165/00128415-199103410-00007.

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Uryu, Kiyoaki, Yoshinori Imamura, Rai Shimoyama, et al. "Stepwise prolongation of overall survival from first- to third-generation EGFR-tyrosine kinase inhibitors in non-small cell lung cancer and the prognostic impact of concomitant antacids." JCO Oncology Practice 19, no. 11_suppl (2023): 530. http://dx.doi.org/10.1200/op.2023.19.11_suppl.530.

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530 Background: The introduction of new-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has afforded promising overall survival (OS) outcomes in clinical trials for non-small cell lung cancer (NSCLC). However, given the high cost associated with these agents, the extent of their adoption and the resulting impact on OS in real-world clinical settings remains uncertain. Concomitant use of antacids reportedly decreases the absorption of first-generation EGFR-TKIs, accompanied by a reduction in OS. Although concomitant antacids do not reduce the absorption of s

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Anil Trailokya, Dr Abhijit, Dr Amar Shirsat, Dr Shaijesh Wankhede, Avinash Talware, and Rahul Raj. "Alginates: Solution for non-cardiac heartburn." Gastroenterology & Hepatology: Open access 15, no. 5 (2024): 157–61. https://doi.org/10.15406/ghoa.2024.15.00594.

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Heartburn is the most common symptom presented by patients in clinical practice. Causes of heartburn ranging from cardiac origin (heart attack) to acid reflux. Different acid suppressing agents like antacids, H2 blockers, PPIs (Proton pump inhibitors) are commonly used. Alginate-based raft-forming products have been used for many years in the management of heartburn and acid reflux disorders and are widely available worldwide. They are commonly used to alleviate symptoms of acid reflux disorders, working through a mechanism distinct from conventional antacids. In the presence of stomach acid,

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Musfiroh, Ida, Aliya Nur Hasanah, Gia A. Faradiba, Ida Ayumiati, Mutakin Mutakin, and Muchtaridi Muchtaridi. "Modification of Extraction Methods on Determining Simeticone Suspension Using FTIR Method." Indonesian Journal of Pharmaceutical Science and Technology 6, no. 3 (2019): 125. http://dx.doi.org/10.24198/ijpst.v6i3.22355.

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Antacids dosage form are a class of drugs used to chemically bind and neutralize stomach acid. Simethicone is one of the antacids that works as an antiflatulant. In an effort to guarantee the quality of a preparation, a valid analysis method is needed that meets the validation parameters. This study aims to modified of extraction method of the simethicone content of suspension samples using the FTIR method. The methods include simethicone modification of extraction from suspension preparations with toluene solvents and hydrochloric acid (2:5) 3.35. Validation methods include: determination of

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Nakamura, Takeaki, Ryosuke Watanabe, Takahiro Yamamura, et al. "Retrospective analysis of drug intake affecting the intestinal microbiota and the therapeutic effects of chemotherapy on gastric cancer." Journal of Clinical Oncology 41, no. 4_suppl (2023): 379. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.379.

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379 Background: Administration of some medications, such as antibiotics, antacids, and probiotic supplementation, may affects the treatment outcomes of immune checkpoint inhibitors (ICIs), through the change of gut microbiota in cancer patients. Even when ICIs are combined with cytotoxic chemotherapy (Chemo), a use of such medications is expected to be a potential biomarker. However, the impacts of medications that affect gut microbiota on the efficacy of Chemo alone is unclear. Methods: We retrospectively analyzed patients who received fluoropyrimidines and platinum-based therapy for advanced

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Mr., Akash D. Surve Ms. Pooja K. Khanzode Mr. Prathamesh S. Shinde Ms. Samiksha M. Pakhare Mr. Shyam G. Rekhe Prof. Rahul V. Jadhav Dr. K. Raja. Rajeswari. "Preparation And Evaluation Of Polyherbal Antacid Powder." International Journal of Pharmaceutical Sciences 2, no. 6 (2024): 317–27. https://doi.org/10.5281/zenodo.11492352.

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Polyherbal antacid formulations have gained popularity due to their potential synergistic effects and perceived safety compared to single-herb formulations. This abstract explores the preparation and formulations of polyherbal antacid tablets or powders, emphasizing the selection of herbs based on their traditional use and scientific evidence supporting their efficacy in alleviating gastrointestinal discomfort. The process involves selecting appropriate herbs, standardizing their constituents, and formulating them into tablets or powders using suitable excipients to ensure stability, bioavaila

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Prasad, Varpe*. "To In Vitro Assessment and Evaluation Liquorice Root Extract for Antacid Activity." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 738–47. https://doi.org/10.5281/zenodo.15596075.

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Gastroesophageal reflux disease and peptic ulcers are common gastrointestinal disorders often treated with synthetic antacids. However, prolonged use of these agents can lead to adverse effects, prompting the search for safer, plant-based alternatives. In this study, the in vitro antacid activity of liquorice (Glycyrrhiza glabra) root extract was evaluated using a simulated gastric acid neutralization model. The extract was prepared using hydroalcoholic solvent extraction and subjected to phytochemical screening, revealing the presence of flavonoids, glycyrrhizin, and saponins—compounds

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Surdea-Blaga, Teodora, Ion Băncilă, Daniela Dobru, et al. "Mucosal Protective Compounds in the Treatment of Gastroesophageal Reflux Disease. A Position Paper Based on Evidence of the Romanian Society of Neurogastroenterology." Journal of Gastrointestinal and Liver Diseases 25, no. 4 (2016): 537–46. http://dx.doi.org/10.15403/jgld.2014.1121.254.dea.

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Background & Aims: Gastroesophageal reflux disease (GERD) therapy is challenging and suppression of acid secretion or prokinetics do not cure all cases. Some drugs with protective action on the esophageal mucosa have been used alternatively or in association with proton pump inhibitors (PPIs) and/or prokinetics. The Romanian Society of Neurogastroenterology undertook an Evidence-Based analysis, from which this position paper evolved. Methods: We performed a systematic literature search in PubMed until October 2015, using the terms: sucralfate, guaiazulene, gaiazulene, dimethicone, al

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Peloquin, Charles A., Amy E. Bulpitt, George S. Jaresko, Roger W. Jelliffe, Gordon T. James, and David E. Nix. "Pharmacokinetics of Pyrazinamide under Fasting Conditions, with Food, and with Antacids." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 18, no. 6 (1998): 1205–11. http://dx.doi.org/10.1002/j.1875-9114.1998.tb03138.x.

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Study Objectives. To determine intrasubject and intersubject variability in, and the effects of food and antacids on, the pharmacokinetics of pyrazinamide (PZA).Design. Randomized, four‐period, crossover phase I study.Subjects. Fourteen healthy men and women volunteers.Interventions. Subjects ingested single doses of PZA 30 mg/kg under fasting conditions twice, without a high‐fat meal and with an aluminum‐magnesium antacid. They also received standard dosages of isoniazid, rifampin, and ethambutol.Measurements and Main Results. Serum was collected for 48 hours and assayed by gas chromatography

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JACOBS, M. G., P. R. CROCKER, W. G. BOWSHER, and H. N. WHITFIELD. "Beware of Antacids!" British Journal of Urology 66, no. 6 (1990): 661. http://dx.doi.org/10.1111/j.1464-410x.1990.tb07207.x.

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