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Journal articles on the topic 'Antagonistes AT₁'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Maillard, Marc P., Catherine Centeno, Åsa Frostell-Karlsson, Hans R. Brunner, and Michel Burnier. "Does protein binding modulate the effect of angiotensin II receptor antagonists?" Journal of the Renin-Angiotensin-Aldosterone System 2, no. 1_suppl (2001): S54—S58. http://dx.doi.org/10.1177/14703203010020010901.

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Introduction Angiotensin II AT 1-receptor antagonists are highly bound to plasma proteins (≥ 99%). With some antagonists, such as DuP-532, the protein binding was such that no efficacy of the drug could be demonstrated clinically. Whether protein binding interferes with the efficacy of other antagonists is not known. We have therefore investigated in vitro how plasma proteins may affect the antagonistic effect of different AT1-receptor antagonists. Methods A radio-receptor binding assay was used to analyse the interaction between proteins and the ability of various angiotensin II (Ang II) anta

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2

Lammek, Bernard, Yasushi Ito, Irene Gavras, and Haralambos Gavras. "Acylation of the N-Terminus of B2 Bradykinin Antagonists with Bulky Substituents Dramatically Increases Potency." Collection of Czechoslovak Chemical Communications 57, no. 9 (1992): 1960–66. http://dx.doi.org/10.1135/cccc19921960.

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While studying structural factors which can influence B2 antagonistic activity we designed and synthesized five new bradykinin (BK) antagonists. Two of them, namely Aaa[D-Arg0, Hyp3, D-Phe7, Leu8]BK and Aca[D-Arg0, Hyp3, D-Phe7, Leu8]BK are among the most potent B2-antagonists of exogeneous BK described to date. The remaining three analogs are also potent B2-antagonists. None of the new compounds contain Thi at position 5 and 8, a change that markedly reduces their cost. The new antagonists have obvious potential as valuable pharmacological tools in the investigation of the role of endogenous

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3

Adhi, Satriyo Restu, and Tarkus Suganda. "Potensi jamur rizosfer bawang merah dalam menekan Fusarium oxysporum f.sp. cepae, penyebab penyakit busuk umbi bawang merah." Kultivasi 19, no. 1 (2020): 1015. http://dx.doi.org/10.24198/kultivasi.v19i1.22877.

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Sari. Penyakit busuk umbi yang disebabkan oleh Fusarium oxysporum f.sp. cepae (Foc) merupakan salah satu penyakit penting pada bawang merah. Pengendalian penyakit busuk umbi yang ramah lingkungan adalah dengan menggunakan pengendalian biologis. Tujuan dari penelitian ini adalah untuk mendapatkan isolat jamur asal rizosfer tanaman bawang merah yang memiliki sifat antagonis terhadap Foc. Penelitian dilaksanakan di Laboratorium Fitopatologi Departemen Hama dan Penyakit Tumbuhan, Fakultas Pertanian, Universitas Padjadjaran, pada bulan November 2017 hingga Januari 2018. Tahapan penelitian ini terdi

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Berg, Gabriele, Christin Zachow, Jana Lottmann, Monika Götz, Rodrigo Costa, and Kornelia Smalla. "Impact of Plant Species and Site on Rhizosphere-Associated Fungi Antagonistic to Verticillium dahliae Kleb." Applied and Environmental Microbiology 71, no. 8 (2005): 4203–13. http://dx.doi.org/10.1128/aem.71.8.4203-4213.2005.

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ABSTRACT Fungi with antagonistic activity toward plant pathogens play an essential role in plant growth and health. To analyze the effects of the plant species and the site on the abundance and composition of fungi with antagonistic activity toward Verticillium dahliae, fungi were isolated from oilseed rape and strawberry rhizosphere and bulk soil from three different locations in Germany over two growing seasons. A total of 4,320 microfungi screened for in vitro antagonism toward Verticillium resulted in 911 active isolates. This high proportion of fungi antagonistic toward the pathogen V. da

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Mamphogoro, Tshifhiwa Paris, Casper Nyaradzai Kamutando, Martin Makgose Maboko, Olayinka Ayobami Aiyegoro, and Olubukola Oluranti Babalola. "Epiphytic Bacteria from Sweet Pepper Antagonistic In Vitro to Ralstonia solanacearum BD 261, a Causative Agent of Bacterial Wilt." Microorganisms 9, no. 9 (2021): 1947. http://dx.doi.org/10.3390/microorganisms9091947.

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Biological control of plant pathogens, particularly using microbial antagonists, is posited as the most effective, environmentally-safe, and sustainable strategy to manage plant diseases. However, the roles of antagonists in controlling bacterial wilt, a disease caused by the most devastating and widely distributed pathogen of sweet peppers (i.e., R. solanacearum), are poorly understood. Here, amplicon sequencing and several microbial function assays were used to depict the identities and the potential antagonistic functions of bacteria isolated from 80 red and green sweet pepper fruit samples

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DINAN, Laurence, Pensri WHITING, Jean-Pierre GIRAULT, et al. "Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor." Biochemical Journal 327, no. 3 (1997): 643–50. http://dx.doi.org/10.1042/bj3270643.

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Two triterpenoids, cucurbitacins B and D, have been isolated from seeds of Iberis umbellata (Cruciferae) and shown to be responsible for the antagonistic activity of a methanolic extract of this species in preventing the 20-hydroxyecdysone (20E)-induced morphological changes in the Drosophila melanogaster BII permanent cell line. With a 20E concentration of 50 nM, cucurbitacins B and D give 50% responses at 1.5 and 10 μM respectively. Both cucurbitacins are able to displace specifically bound radiolabelled 25-deoxy-20-hydroxyecdysone (ponasterone A) from a cell-free preparation of the BII cell

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7

Karunasinghe, Thamodini G., S. S. N. Maharachchikumbura, Rethinasamy Velazhahan, and Abdullah M. Al-Sadi. "Antagonistic Activity of Endophytic and Rhizosphere Fungi Isolated From Sea Purslane (Sesuvium portulacastrum) Against Pythium Damping off of Cucumber." Plant Disease 104, no. 8 (2020): 2158–67. http://dx.doi.org/10.1094/pdis-01-20-0003-re.

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This study was conducted to investigate the antagonistic activity of endophytic and rhizosphere fungi isolated from a medicinal plant, Sesuvium portulacastrum, against Pythium aphanidermatum, the cause of damping off of cucumber. A total of 40 endophytic and 19 rhizosphere fungi were isolated from S. portulacastrum. Three endophytic isolates and two rhizosphere isolates gave >50% suppression of P. aphanidermatum in the in vitro dual-culture tests. Scanning electron microscopic studies at the inhibition zone showed hyphae wall damage and abnormal mycelial growth of the genus Pythium. Molecul

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8

Beasley, D. R., D. C. Joyce, L. M. Coates, and A. H. Wearing. "Saprophytic microorganisms with potential for biological control of Botrytis cinerea on Geraldton waxflower flowers." Australian Journal of Experimental Agriculture 41, no. 5 (2001): 697. http://dx.doi.org/10.1071/ea00112.

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Saprophytic bacteria, yeasts and filamentous fungi were isolated from Geraldton waxflower flowers and screened to identify potential antagonism towards Botrytis cinerea. Isolates from other sources (e.g. avocado) were also tested. Isolates were initially screened in vitro for inhibition of B. cinerea conidial germination, germ tube elongation and mycelial growth. The most antagonistic bacteria, yeasts and fungi were selected for further testing on detached waxflower flowers. Conidia of the pathogen were mixed with conidia or cells of the selected antagonists, co-inoculated onto waxflower flowe

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Oro, Violeta, Jelena Boskovic, Slobodan Milenkovic, and Solveig Tosi. "Taxonomic diversity of fungi associated with some PCN populations from Serbia." Pesticidi i fitomedicina 27, no. 1 (2012): 41–47. http://dx.doi.org/10.2298/pif1201041o.

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Increased content of pesticides in food chain resulted in using microorganisms as agents of biological control. The potato cyst nematodes (PCN) - Globodera pallida and G. rostochiensis belong to the group of the most important parasites - the quarantine organisms. The external and internal area of a cyst harbor numerous fungal and bacterial species. The aim of this study was to identify antagonistic fungi associated with some PCN populations from Serbia. Fungal antagonists of potato cyst nematodes have not been previously investigated in our country. The diversity of PCN fungal antagonists is

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Samaneh, Samavat, Asghar Heydari, Hamid Reza Zamanizadeh, Saeed Rezaee, and Ali Alizadeh Aliabadi. "A comparison between Pseudomonas aureofaciens (chlororaphis) and P. fluorescens in biological control of cotton seedling damping-off disease." Journal of Plant Protection Research 54, no. 2 (2014): 115–21. http://dx.doi.org/10.2478/jppr-2014-0019.

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Abstract Due to the importance of the biological control of plant diseases, testing and introducing new biocontrol-active microorganisms is a major concern among plant pathologists. The causal agent of cotton seedling damping-off disease is Rhizoctonia solani. In this regard, we tried to investigate the antagonistic activities of Pseudomonas aureofaciens (chlororaphis) 30–84 (phenazine producing wild type and non-phenazine producing mutant) strains on R. solani, in comparison with some isolates of P. fluorescent under both in vitro (laboratory) and in vivo (greenhouse) conditions. In the labor

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11

ACHMAD, ACHMAD, and DEKA YULISMAN. "POTENSI DUA ISOLAT LOKAL Pleurotus sp. SEBAGAI ANTAGONIS TERHADAP Ganoderma sp." Jurnal Penelitian Tanaman Industri 17, no. 4 (2020): 174. http://dx.doi.org/10.21082/jlittri.v17n4.2011.174-178.

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<p>ABSTRAK</p><p>Pleurotus sp. merupakan salah satu jamur yang lebih dikenalsebagai jamur pangan. Selain sebagai jamur pangan, jamur tersebut jugadilaporkan memiliki kemampuan antimikrobial. Dalam penelitian inidipelajari potensi isolat lokal Pleurotus sp. sebagai antagonis terhadapfungi patogen Ganoderma sp. yang merupakan penyebab penyakit pentingpada tanaman perkebunan terutama kelapa sawit. Penelitian dilakukan diLaboratorium Penyakit Hutan Fakultas Kehutanan IPB dari bulan Julisampai dengan Oktober 2004. Penelitian menggunakan dua isolat lokalPleurotus sp.1 dan Pleurotus

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12

Köhl, J., R. R. Bélanger, and N. J. Fokkema. "Interaction of Four Antagonistic Fungi with Botrytis aclada in Dead Onion Leaves: A Comparative Microscopic and Ultrastructural Study." Phytopathology® 87, no. 6 (1997): 634–42. http://dx.doi.org/10.1094/phyto.1997.87.6.634.

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The colonization of dead onion leaves by Botrytis aclada and the fungal antagonists Aureobasidium pullulans, Chaetomium globosum, Glio-cladium catenulatum, and Ulocladium atrum and the interactions between B. aclada and each of the four antagonists were studied at the microscopic and ultrastructural level. This approach was used in an attempt to understand the colonization pattern of these fungi and the nature of the biocontrol activity of the antagonists that have shown a potential to suppress spore production of Botrytis spp. on necrotic plant tissues. When applied alone, B. aclada and U. at

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13

Otto-Hanson, L. K., Z. Grabau, C. Rosen, C. E. Salomon, and L. L. Kinkel. "Pathogen Variation and Urea Influence Selection and Success of Streptomyces Mixtures in Biological Control." Phytopathology® 103, no. 1 (2013): 34–42. http://dx.doi.org/10.1094/phyto-06-12-0129-r.

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Success in biological control of plant diseases remains inconsistent in the field. A collection of well-characterized Streptomyces antagonists (n = 19 isolates) was tested for their capacities to inhibit pathogenic Streptomyces scabies (n = 15 isolates). There was significant variation among antagonists in ability to inhibit pathogen isolates and among pathogens in their susceptibility to inhibition. Only one antagonist could inhibit all pathogens, and antagonist–pathogen interactions were highly specific, highlighting the limitations of single-strain inoculum in biological control. However, t

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GUINEBRETIERE, M. H., C. NGUYEN-THE, N. MORRISON, M. REICH, and P. NICOT. "Isolation and Characterization of Antagonists for the Biocontrol of the Postharvest Wound Pathogen Botrytis cinerea on Strawberry Fruits." Journal of Food Protection 63, no. 3 (2000): 386–94. http://dx.doi.org/10.4315/0362-028x-63.3.386.

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Antagonistic bacteria and yeasts were isolated from the epiphytic flora of stored strawberry fruits and evaluated for their ability to protect strawberry fruit wounds after harvest against Botrytis cinerea. Among selected potential antagonists, three strains of Candida reukaufii (5L3, 10CL4, 10L2) and one strain of Candida pulcherima (10L8) still protected fruit wounds when applied at 103 CFU/wound, reducing lesion or conidiophore development. In the same conditions, two Enterobacteriaceae (10B1, 5B4) highly reduced pathogen development. Strain 5B4 was still highly inhibitory when inoculated a

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15

Dove, Stefan, Martin C. Michel, Sebastian Knieps, and Armin Buschauer. "Pharmacology and quantitative structure-activity relationships of imidazolylpropylguanidines with mepyramine-like substructures as non-peptide neuropeptide Y Y1 receptor antagonists." Canadian Journal of Physiology and Pharmacology 78, no. 2 (2000): 108–15. http://dx.doi.org/10.1139/y99-120.

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The design of non-peptide, Y1-selective antagonists of neuropeptide Y (NPY) as pharmacological tools is in progress and is increasingly important as therapeutic applications are expected. Starting from the potent histamine H2 agonist and weak NPY Y1 antagonist arpromidine, 16 imidazolylpropylguanidine derivatives were synthesized and tested for Y1 antagonistic activity (inhibition of NPY-stimulated Ca2+ increase in human erythroleukemic cells), where the pheniramine-like moiety of arpromidine was replaced with 2-pyridylaminoalkyl, benzyl-(2-pyridyl)aminoalkyl, and phenyl-(2-pyridyl)alkylaminoa

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Pal, P. K., A. Samii, M. Schulzer, E. Mak, and J. K. C. Tsui. "Head Tremor in Cervical Dystonia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 27, no. 2 (2000): 137–42. http://dx.doi.org/10.1017/s0317167100052240.

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ABSTRACT:Objective:To compare the clinical characteristics, natural history, and therapeutic outcome of patients with cervical dystonia (CD) with head tremor (HT+) and without head tremor (HT-).Methods:We prospectively evaluated 114 consecutive patients of CD over a 9-month period with a detailed questionnaire. Chi-square and t-tests were employed for statistical analysis.Results:Seventy-eight (68.4%) patients had head tremor and 27 of them (34.6%) had tremor as one of the first symptoms. Age at onset of symptoms were similar in HT+ and HT- groups; however there was a higher prevalence in wome

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17

Sarker, AM, N. Sultana, MR Islam, M. Rashid, and ZR Bhuian. "Efficacy of Some Rhizosphere Microorganisms in Controlling Fusarium Wilt of Tomato (Lycopersicon esculentum)." Agriculturists 11, no. 2 (2014): 96–103. http://dx.doi.org/10.3329/agric.v11i2.17494.

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An experiment was conducted at the Disease Diagnostic Laboratory and Net House of Plant Pathology Department, Sher-e-Bangla Agricultural University, Dhaka during July 2011 to June 2012 to investigate the efficacy of some antagonistic rhizosphere microorganisms against Fusarium oxysporum f. sp. lycopersici causing Fusarium wilt of tomato. Probable 20 antagonistic bacterial isolates and one antagonistic fungal isolate (Trichoderma harzianum) from rhizosphere soil were screened out against F. oxysporum f. sp. lycopersici. Out of 20 bacterial isolates, only four (Iso-1, Iso-2, Iso-3 and Iso-4) wer

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da Silva Ferreira, Natiele C., Luiz A. Alves, and Rômulo J. Soares-Bezerra. "Potential Therapeutic Applications of P2 Receptor Antagonists: From Bench to Clinical Trials." Current Drug Targets 20, no. 9 (2019): 919–37. http://dx.doi.org/10.2174/1389450120666190213095923.

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Background: Extracellular purines and pyrimidines have important physiological functions in mammals. Purines and pyrimidines act on P1 and P2 purinergic receptors, which are widely expressed in the plasma membrane in various cell types. P2 receptors act as important therapeutic targets and are associated with several disorders, such as pain, neurodegeneration, cancer, inflammation, and thrombosis. However, the use of antagonists for P2 receptors in clinical therapy, with the exception of P2Y12, is a great challenge. Currently, many research groups and pharmaceutical companies are working on th

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Kortenkamp, Andreas, Martin Scholze, and Sibylle Ermler. "Mind the gap: can we explain declining male reproductive health with known antiandrogens?" REPRODUCTION 147, no. 4 (2014): 515–27. http://dx.doi.org/10.1530/rep-13-0440.

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Several countries have experienced rises in cryptorchidisms, hypospadias and testicular germ cell cancer. The reasons for these trends are largely unknown, but Skakkebaek has proposed that these disorders form a testicular dysgenesis syndrome and can be traced to androgen insufficiency in foetal life. This suggests that antiandrogenic chemicals might contribute to risks, but few chemicals have been linked to these diseases in epidemiological studies. In animal studies with p,p′-dichlorodiphenyldichloroethylene, effects typical of disruptions of male sexual differentiation became apparent when

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Gebrewahd, Meressa Tsehaye. "Securitization and Militarization of The Border: Security Dilemma in Post-1998 Ethiopia and Eritrea." Afrika Tanulmányok / Hungarian Journal of African Studies 12, no. 4. (2019): 82–100. http://dx.doi.org/10.15170/at.2018.12.4.6.

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The post-1991 Ethiopia and Eritrea were hoped to become promising and exemplary states in Africa. But, after seven years of euphoria, national stability and security trapped both countries into a bloody conflict, and their relation is now in structural crisis: the ‘no war, no peace’ dilemma. Their security dilemmas are basically centered on the antagonistic foreign and national security as well as nation-building policies. The post-independence nation-building attempt to forge a militarized single national identity in Eritrea, under the motto of “one people, one heart” and the remaking of the

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Fenwick, Mark A., Yosef T. Mansour, Stephen Franks, and Kate Hardy. "Identification and Regulation of Bone Morphogenetic Protein Antagonists Associated with Preantral Follicle Development in the Ovary." Endocrinology 152, no. 9 (2011): 3515–26. http://dx.doi.org/10.1210/en.2011-0229.

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The TGFβ superfamily comprises several bone morphogenetic proteins (BMP) capable of exerting gonadotropin-independent effects on the development of small preantral follicles. In embryonic tissues, BMP concentration gradients, partly formed by antagonistic factors, are essential for establishing phenotypic fate. By examining the expression of candidate genes whose protein products are known to interact with BMP ligands, we set out to determine which antagonists would most likely contribute toward regulation of paracrine signaling during early follicle development. Juvenile mouse ovaries of 4, 8

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Perl, J. "Load Optimization in Endurance Sports by Means of Antagonistic Dynamical Models." IFAC Proceedings Volumes 45, no. 2 (2012): 810–13. http://dx.doi.org/10.3182/20120215-3-at-3016.00143.

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23

PRAZDNOVA, E. V., A. V. GOROVTSOV, V. A. CHISTYAKOV, N. G. VASILCHENKO, and L. E. KUKHARENKO. "THE INFLUENCE OF SOIL TYPE AND PRECEDING CROP ON THE SUPPRESSION OF FUSARIUM BY INDIGENOUS SPORE-FORMING BACTERIA." Periódico Tchê Química 16, no. 33 (2019): 225–40. http://dx.doi.org/10.52571/ptq.v16.n33.2019.240_periodico33_pgs_225_240.pdf.

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Restoring and improving soil fertility, increasing the productivity of cultivated plants is one of the objectives of agricultural production. The aim of the present work was to study the antagonistic interactions between the soil bacteria of the order Bacillales and phytopathogenic fungi. The spore-forming soil bacteria attract increasing interest as biocontrol agents, but little is known about the influence of local soil conditions on the development of antagonism in indigenous bacterial strains. This can lead to unsuccessful attempts of bacterial antagonists isolation. To determine the seque

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&NA;. "Looking at novel calcium antagonists." Inpharma Weekly &NA;, no. 855 (1992): 10. http://dx.doi.org/10.2165/00128413-199208550-00016.

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HANK6OSLASH9, E. "Calcium antagonists at high altitude." American Journal of Hypertension 8, no. 4 (1995): 74A. http://dx.doi.org/10.1016/0895-7061(95)97638-8.

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Ding, Haiming, Adlina Mohd Yusof, Shankaran Kothandaraman, et al. "Localization of CaSR Antagonists in CaSR-expressing Medullary Thyroid Cancer." Journal of Clinical Endocrinology & Metabolism 98, no. 11 (2013): E1722—E1729. http://dx.doi.org/10.1210/jc.2013-1756.

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Objective: Image-based localization of medullary thyroid cancer (MTC) and parathyroid glands would improve the surgical outcomes of these diseases. MTC and parathyroid glands express high levels of calcium-sensing receptor (CaSR). The aim of this study was to prove the concept that CaSR antagonists specifically localize to CaSR-expressing tumors in vivo. Design: We synthesized two isomers of a known CaSR calcilytic, Calhex 231, and four new analogs, which have a favorable structure for labeling. Their antagonistic activity was determined using immunoblots demonstrating decreased ERK1/2 phospho

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Nara-Kusuma, Anak Agung Ngurah, Yan Ramona, and Meitini Wahyuni Proborini. "IDENTIFICATION OF MICROBES ANTAGONISTIC AGAINST Fusarium oxysporum ISOLATED FROM RHIZOSPHERE ZONE OF WATERMELON." Jurnal Biologi Udayana 22, no. 2 (2018): 71. http://dx.doi.org/10.24843/jbiounud.2018.v22.i02.p04.

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This research was aimed to isolate and identify microbes which antagonistic against Fusarium oxysporum, the causative agent of vascular wilt in watermelon plants. The antagonistic microbes were isolated from soil samples collected from rhizosphere of watermelon farm located at west Sanur village, South Denpasar, Bali. Isolation of fungi and bacteria were conducted on potato dextrose agar medium (PDA) and nutrient agar medium (NA), respectively. Fungal isolates were then observed under light microscope for its morphological characteristics before identification using a reference book. Bacterial

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Kamykowski, Jeffrey, Peter Carlton, Siddharth Sehgal та Brian Storrie. "Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet α-granules". Blood 118, № 5 (2011): 1370–73. http://dx.doi.org/10.1182/blood-2011-01-330910.

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Abstract Platelets are small anucleate blood cells that aggregate to seal leaks at sites of vascular injury and are important in the pathology of atherosclerosis, acute coronary syndromes, rheumatoid arthritis, cancer, and the regulation of angiogenesis. In all cases, platelet aggregation requires release of stored proteins from α-granules. However, how proteins with potentially antagonistic functions are packaged within α-granules is controversial. One possibility is the packaging of functional agonists and antagonists into different α-granule populations. By quantitative immunofluorescence c

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Siapera, Eugenia, and Michael Theodosiadis. "(Digital) Activism at the Interstices: Anarchist and Self-Organizing Movements in Greece." tripleC: Communication, Capitalism & Critique. Open Access Journal for a Global Sustainable Information Society 15, no. 2 (2017): 505–23. http://dx.doi.org/10.31269/triplec.v15i2.768.

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The paper traces the history and evolution of the anarchist and self-organising movements in Greece, paying attention to their communicative practices and their implications for political praxis. After years of repression, and following the hegemony of the social democratic Pasok, and subsequently Syriza, the movements are currently coming to their own. Beginning with a brief history of the movements and more broadly of the left in Greece, the paper focuses on the current moment, determined by three events: the revolt of 2008, the movement of the squares in 2011, and the rise and u-turn of Syr

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Kolyvas, Efthymios, and Anthony Tzes. "Model based design of antagonistic shape memory alloy spring devices." Journal of Intelligent Material Systems and Structures 29, no. 12 (2018): 2619–40. http://dx.doi.org/10.1177/1045389x18770880.

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Shape memory alloy actuated devices employing a network of antagonistic components can reach an equilibrium of the internal forces by multiple sets of individual force magnitudes. In networks of star topologies particularly, the actuators are placed radially with one end connected at a common node. The ability to produce multiple sets of force equilibria suggests then that similar motions of the common node correspond to different thermomechanical paths. Two factors linked to this behavior are examined in this work, namely the initial design of the antagonistic system and the operational profi

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Asano, Masayuki, Hiroe Sawai, Chie Hatori, Noriaki Inamura, Tatsujiro Fujiwara, and Kunio Nakahara. "Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on guinea-pig tracheal smooth muscle bradykinin receptors." Canadian Journal of Physiology and Pharmacology 76, no. 10-11 (1998): 1051–55. http://dx.doi.org/10.1139/y98-098.

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It is speculated that bradykinin may play an important role in asthma. Thus, bradykinin receptor antagonists may have therapeutic potential against asthma. Orally active bradykinin antagonists would be more desirable for the treatment of the disease. In the present study, we examined the effects of a novel, potent, selective, and orally active nonpeptide bradykinin B2 receptor antagonist, FR167344 (N-[N-[3-[(3-bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]- 2,4-dichlorophenyl]-N-methylaminocarbonylmethyl]-4-(dimethylaminocarbonyl)cinnamylamide hydrochloride), on guinea-pig tracheal smooth

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Sabogal Venegas, John Edison. "Las apuestas étnicas por la paz: antagonismos democráticos y diálogos sociales reticulares." REVISTA CONTROVERSIA, no. 214 (August 11, 2020): 15–48. http://dx.doi.org/10.54118/controver.vi214.1199.

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Este artículo presenta una reconstrucción interpretativa de la incidencia de las organizaciones indígenas y afrodescendientes en el proceso de negociación de paz de La Habana. A partir del análisis de los diferentes repertorios de acción y de las dinámicas antagónicas que los liderazgos étnicos construyeron para hacer visibles sus demandas y propuestas, se propone una reflexión sobre las posibilidades que brindan los diálogos sociales reticulares para la construcción de paz. Reconociendo el rol de las articulaciones políticas que condujeron a nivel nacional a la conformación de la Comisión Étn

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SPEDDING, MICHAEL. "Antagonists and Activators at Calcium Channels." Annals of the New York Academy of Sciences 522, no. 1 Calcium Antag (1988): 248–58. http://dx.doi.org/10.1111/j.1749-6632.1988.tb33362.x.

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Susman, Ed. "Critical finger pointed at calcium antagonists." Inpharma Weekly &NA;, no. 1258 (2000): 11–12. http://dx.doi.org/10.2165/00128413-200012580-00025.

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Tsekhmister, G. V., A. S. Kyslynska, and A. A. Pavlenko. "ANTAGONISTIC ACTIVITY OF SOIL MICROORGANISMS AS AN EFFECTIVE MEANS OF PLANT PROTECTION AGAINST ACCREMONIOSIS." Agriciltural microbiology 30 (December 3, 2019): 46–53. http://dx.doi.org/10.35868/1997-3004.30.46-53.

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Objective. Screening of microorganisms — antagonists of the phytopathogenic fungus Acremonium cucurbitacearum. Methods. The antagonistic activity of microorganisms was investigated by the method of mixed (counter) cultures on wort agar. The appearance and type of relationships were registered using Simonian and Mamikonian modified scale. The primary screening of A. cucurbitacearum 502 antagonists was performed by the delayed antagonism method. Morphological and cultural characteristics of Triсhoderma sp. 017 were studied on wort agar. The fungus was grown for 10 days. Results. Almost all of th

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Martins, Káthia Santana, Lorena Tirza de Assis Magalhães, Jeferson Geison de Almeida, and Fábio Alessandro Pieri. "Antagonism of Bacteria from Dog Dental Plaque against Human Cariogenic Bacteria." BioMed Research International 2018 (November 4, 2018): 1–6. http://dx.doi.org/10.1155/2018/2780948.

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Dental caries are a process of demineralization and destruction of human teeth. They originate through many factors and are associated with biofilm formation, which consists of bacteria adhered to the teeth that form a structurally and functionally organized mass called dental plaque. Both the presence ofStreptococcus mutansand the frequent consumption of sucrose correlate with a higher prevalence of caries in humans. In dogs, however, the incidence of this disease is low, due to factors such as differences in dental microbiota and/or their low consumption of sucrose. This work evaluated the a

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Lyousfi, Nadia, Rachid Lahlali, Chaimaa Letrib, et al. "Improving the Biocontrol Potential of Bacterial Antagonists with Salicylic Acid against Brown Rot Disease and Impact on Nectarine Fruits Quality." Agronomy 11, no. 2 (2021): 209. http://dx.doi.org/10.3390/agronomy11020209.

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The main objective of this study was to evaluate the ability of both antagonistic bacteria Bacillus amyloliquefaciens (SF14) and Alcaligenes faecalis (ACBC1) used in combination with salicylic acid (SA) to effectively control brown rot disease caused by Monilinia fructigena. Four concentrations of salicylic acid (0.5%, 2%, 3.5%, and 5%) were tested under in vitro and in vivo conditions. Furthermore, the impact of biological treatments on nectarine fruit parameters’ quality, in particular, weight loss, titratable acidity, and soluble solids content, was evaluated. Regardless of the bacterium, t

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Hoyer, Inna, Ann-Karin Haas, Annika Kreuchwig, Ralf Schülein, and Gerd Krause. "Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists." Biochemical Society Transactions 41, no. 1 (2013): 213–17. http://dx.doi.org/10.1042/bst20120319.

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The TSHR (thyrotropin receptor) is activated endogenously by the large hormone thyrotropin and activated pathologically by auto-antibodies. Both activate and bind at the extracellular domain. Recently, SMLs (small-molecule ligands) have been identified, which bind in an allosteric binding pocket within the transmembrane domain. Modelling driven site-directed mutagenesis of amino acids lining this pocket led to the delineation of activation and inactivation sensitive residues. Modified residues showing CAMs (constitutively activating mutations) indicate signalling-sensitive positions and mark p

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Abu-Khalaf, Nawaf. "Sensing tomato’s pathogen using Visible/Near infrared (VIS/NIR) spectroscopy and multivariate data analysis (MVDA)." مجلة جامعة فلسطين التقنية خضوري للأبحاث 3, no. 1 (2015): 12–22. http://dx.doi.org/10.53671/ptukrj.v3i1.35.

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Quality of agricultural products is a very important issue for consumers as well as for farmers in relation to price, health and flavour. One of the factors that determine the quality is the absence of pathogens that can cause diseases for products and also for consumers. An advanced method to sense pathogens and their antagonists is the use of Visible/Near Infrared (VIS/NIR) spectroscopy. In this paper, the VIS/NIR spectroscopy, with the help of two techniques of multivariate data analysis (MVDA); namely principal component analysis (PCA) and support vector machine (SVM)-classification; showe

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Abu-Khalaf, Nawaf. "Sensing tomato’s pathogen using Visible/Near infrared (VIS/NIR) spectroscopy and multivariate data analysis (MVDA)." مجلة جامعة فلسطين التقنية للأبحاث 3, no. 1 (2015): 12–22. http://dx.doi.org/10.53671/pturj.v3i1.35.

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Quality of agricultural products is a very important issue for consumers as well as for farmers in relation to price, health and flavour. One of the factors that determine the quality is the absence of pathogens that can cause diseases for products and also for consumers. An advanced method to sense pathogens and their antagonists is the use of Visible/Near Infrared (VIS/NIR) spectroscopy. In this paper, the VIS/NIR spectroscopy, with the help of two techniques of multivariate data analysis (MVDA); namely principal component analysis (PCA) and support vector machine (SVM)-classification; showe

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Benyagoub, Mohammed, Nicole Benhamou, and Odile Carisse. "Cytochemical Investigation of the Antagonistic Interaction Between a Microsphaeropsis sp. (Isolate P130A) and Venturia inaequalis." Phytopathology® 88, no. 7 (1998): 605–13. http://dx.doi.org/10.1094/phyto.1998.88.7.605.

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In an attempt to better understand the mode of action of the antagonistic fungus Microsphaeropsis sp., the interaction between this fungus and Venturia inaequalis was studied, using both light and electron microscopy. Cytological observations indicated that the antagonistic interaction between the two fungi likely involves a sequence of events, including (i) attachment and local penetration of Microsphaeropsis sp. into V. inaequalis hyphae; (ii) induction of host structural response at sites of potential antagonist entry; (iii) alteration of host cytoplasm; and (iv) active multiplication of an

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Miranda, C. M. S., L. M. Farias, M. A. R. Carvalho, et al. "Purification and partial characterization of a bacteriocin isolated from Bacteroides ovatus H47." Canadian Journal of Microbiology 39, no. 2 (1993): 169–74. http://dx.doi.org/10.1139/m93-023.

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A new intracellular bacteriocin isolated from a human fecal strain of Bacteroides ovatus was partially purified through ammonium sulfate precipitation, ion exchange chromatography, gel filtration, and preparative polyacrylamide gel electrophoresis (PAGE). The bacteriocin is stable at a pH range of 3–10, at 60 °C for 24 h, and at −70 °C for 6 months. It is inactivated by proteolytic enzymes. The molecular weight, estimated by sodium dodecyl sulfate – PAGE, is 78 kDa. Fifty strains of the Bacteroides fragilis group were isolated from fecal samples, and 41 of the isolates were shown to produce an

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Wang, Mukuo, Shujing Hou, Yu Wei, Dongmei Li, and Jianping Lin. "Discovery of novel dual adenosine A1/A2A receptor antagonists using deep learning, pharmacophore modeling and molecular docking." PLOS Computational Biology 17, no. 3 (2021): e1008821. http://dx.doi.org/10.1371/journal.pcbi.1008821.

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Adenosine receptors (ARs) have been demonstrated to be potential therapeutic targets against Parkinson’s disease (PD). In the present study, we describe a multistage virtual screening approach that identifies dual adenosine A1 and A2A receptor antagonists using deep learning, pharmacophore models, and molecular docking methods. Nineteen hits from the ChemDiv library containing 1,178,506 compounds were selected and further tested by in vitro assays (cAMP functional assay and radioligand binding assay); of these hits, two compounds (C8 and C9) with 1,2,4-triazole scaffolds possessing the most po

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Cheney, P. D., E. E. Fetz, and S. S. Palmer. "Patterns of facilitation and suppression of antagonist forelimb muscles from motor cortex sites in the awake monkey." Journal of Neurophysiology 53, no. 3 (1985): 805–20. http://dx.doi.org/10.1152/jn.1985.53.3.805.

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Patterns of excitatory and inhibitory effects were produced in antagonistic forelimb muscles by single intracortical microstimuli (S-ICMS) applied to motor cortex sites in macaque monkeys performing ramp-and-hold wrist movements. Stimulus-triggered averages (stimulus-TAs) of rectified electromyographic (EMG) activity revealed poststimulus facilitation and/or suppression in identified flexor and extensor muscles of the wrist and fingers. At 22 cortical sites the action potentials of single cells were also recorded and used to compute spike-triggered averages (spike-TAs) of covarying muscles. Th

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Papkou, Andrei, Thiago Guzella, Wentao Yang, et al. "The genomic basis of Red Queen dynamics during rapid reciprocal host–pathogen coevolution." Proceedings of the National Academy of Sciences 116, no. 3 (2018): 923–28. http://dx.doi.org/10.1073/pnas.1810402116.

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Red Queen dynamics, involving coevolutionary interactions between species, are ubiquitous, shaping the evolution of diverse biological systems. To date, information on the underlying selection dynamics and the involved genome regions is mainly available for bacteria–phage systems or only one of the antagonists of a eukaryotic host–pathogen interaction. We add to our understanding of these important coevolutionary interactions using an experimental host–pathogen model, which includes the nematode Caenorhabditis elegans and its pathogen Bacillus thuringiensis. We combined experimental evolution

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Ilham, Barakat, Chtaina Noureddine, Grappin Philippe, et al. "Induced Systemic Resistance (ISR) in Arabidopsis thaliana by Bacillus amyloliquefaciens and Trichoderma harzianum Used as Seed Treatments." Agriculture 9, no. 8 (2019): 166. http://dx.doi.org/10.3390/agriculture9080166.

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The Trichoderma fungal species and the bacteria Bacillus species were described as inducers of plant systemic resistance in relation to their antagonistic activity. The objective of this study was to evaluate the effect of selected strains of Bacillus amyloliquefaciens (I3) and Trichoderma harzianum (A) on inducing systemic resistance in Arabidopsis thaliana as a model for plant molecular genetics. The microorganisms were identified and were confirmed for their antagonistic potential in vitro and in vivo in previous studies. In order to explore this mechanism, two mutants of A. thaliana carryi

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Baraldi, Pier, Francesco Virgilio, and Romeo Romagnoli. "Agonists and Antagonists Acting at P2X7 Receptor." Current Topics in Medicinal Chemistry 4, no. 16 (2004): 1707–17. http://dx.doi.org/10.2174/1568026043387223.

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Alexander, Stephen P. H. "Flavonoids as antagonists at A1 adenosine receptors." Phytotherapy Research 20, no. 11 (2006): 1009–12. http://dx.doi.org/10.1002/ptr.1975.

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Carroll, F. Ivy. "Antagonists at Metabotropic Glutamate Receptor Subtype 5." Annals of the New York Academy of Sciences 1141, no. 1 (2008): 221–32. http://dx.doi.org/10.1196/annals.1441.015.

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Lohse, M. J., K. N. Klotz, K. H. Jakobs, and U. Schwabe. "Barbiturates Are Selective Antagonists at A1Adenosine Receptors." Journal of Neurochemistry 45, no. 6 (1985): 1761–70. http://dx.doi.org/10.1111/j.1471-4159.1985.tb10532.x.

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