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Journal articles on the topic 'Anthelmintic action'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

André, Weibson Paz Pinheiro, Wesley Lyeverton Correia Ribeiro, Lorena Mayana Beserra de Oliveira, Iara Tersia Freitas Macedo, Fernanda Cristina Macedo Rondon, and Claudia Maria Leal Bevilaqua. "Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants." Acta Scientiae Veterinariae 46, no. 1 (2018): 14. http://dx.doi.org/10.22456/1679-9216.81804.

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Background: Gastrointestinal nematodes are one of the major health and economic problem of sheep and goats in the world. The control of these nematodes is carried out conventionally with synthetic anthelminths, which favored the selection of gastrointestinal nematode (GIN) populations multiresistant to anthelmintics. The emergence of anthelmintic resistance has stimulated the search for new alternatives to control small ruminant GIN, standing out the use of plants and their bioactives compounds, such as essential oils (EO). The objective of this review was to present the main characteristics a

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Martin, R. J., M. A. Valkanov, V. M. E. Dale, A. P. Robertson, and I. Murray. "Electrophysiology ofAscarismuscle and anti-nematodal drug action." Parasitology 113, S1 (1996): S137—S156. http://dx.doi.org/10.1017/s0031182000077945.

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SUMMARYThree groups of anthelmintic drugs act directly and selectively on muscle membrane receptors of parasitic nematodes. These groups of anthelmintics are: (1)The Nicotinic Agonists(levamisole, pyrantel, morantel and oxantel) that act on acetylcholine receptors of nematode somatic muscle; (2)The GAB A Agonist, piperazine, that acts on nematode muscle GABA receptors; and (3)The Avermectinsthat open glutamate gated Cl-channels on nematode pharyngeal muscle. The electrophysiology and pharmacology of muscle and neuromuscular transmission the nematode parasite,Ascaris suum, is outlined and effec

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De Graef, J., E. Claerebout, and P. Geldhof. "Anthelmintic resistance of gastrointestinal cattle nematodes." Vlaams Diergeneeskundig Tijdschrift 82, no. 3 (2013): 113–23. http://dx.doi.org/10.21825/vdt.v82i3.16703.

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Anthelmintic resistance of parasites in small ruminants, cattle and horses is increasing worldwide as a consequence of the over usage of the currently available products. In Belgium, Cooperia oncophora is the most common cattle nematode in which resistance, especially against macrocyclic lactones, occurs. Once resistance has been diagnosed, a change to another drug with a different mode of action is advised. However, effective anthelmintics will be hardly available in the near future. Therefore, it is important that farmers and veterinarians find a balance between achieving good parasite contr

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De Herdt, P., T. Timmerman, P. Defoort, K. Lycke, and R. Jaspers. "Fowl adenovirus infections in Belgian broilers: a ten-year survey." Vlaams Diergeneeskundig Tijdschrift 82, no. 3 (2013): 125–33. http://dx.doi.org/10.21825/vdt.v82i3.16704.

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Anthelmintic resistance of parasites in small ruminants, cattle and horses is increasing worldwide as a consequence of the over usage of the currently available products. In Belgium, Cooperia oncophora is the most common cattle nematode in which resistance, especially against macrocyclic lactones, occurs. Once resistance has been diagnosed, a change to another drug with a different mode of action is advised. However, effective anthelmintics will be hardly available in the near future. Therefore, it is important that farmers and veterinarians find a balance between achieving good parasite contr

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Fleming, J. T., H. A. Baylis, D. B. Sattelle, and J. A. Lewis. "Molecular cloning andin vitroexpression ofC. elegansand parasitic nematode ionotropic receptors." Parasitology 113, S1 (1996): S175—S190. http://dx.doi.org/10.1017/s0031182000077969.

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SUMMARYThe free living nematode,C. elegansis understood at a level of detail equalled by few other organisms, and much of the cell biology and sequence information is proving of considerable utility in the study of parasitic nematodes. Already,C. elegansprovides a convenient vehicle for investigating anthelmintic drug action and resistance mechanisms. Among the ionotropic receptors, with their important roles in the behaviour and development of the organism, are targets for anthelmintics. The subunits of nicotinic acetylcholine receptors ofC. elegansform a large and diverse multigene family. M

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Yesudanam, Sinchu, Aparna Raj A. S., Jothika J., R. S. Sreelakshmi, and Soniya M. Sunil. "Anthelmintic Screening of Hylocereus polyrhizus Rind Extracts." Journal of International Research in Medical and Pharmaceutical Sciences 19, no. 3 (2024): 1–8. http://dx.doi.org/10.56557/jirmeps/2024/v19i38812.

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The purpose of this study was to evaluate the rind extract of Hylocereus polyrhizus's anthelmintic efficacy. Ethanol and water were utilized to extract the powdered rind of H. polyrhizus. The phytochemical screening of H. polyrhizus ethanol extract (HPEE) and water extract (HPAE) was done. The adult motility assay and resistance-modifying study were then used to screen for the plant's anthelmintic properties against Eudrilus eugeniae. Due to its morphological and physiological resemblance to the human intestinal roundworm, Eudrilus eugeniae was chosen in the investigation. On E. eugeniae, HPEE

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Harnett, W. "The anthelmintic action of praziquantel." Parasitology Today 4, no. 5 (1988): 144–46. http://dx.doi.org/10.1016/0169-4758(88)90192-5.

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Hajnal, Kelemen, Mărcuțiu Petra Edina, Rausz Adrienn, and Papp Lajos-Attila. "Chemical and pharmacological characterization of anthelmintic benzimidazoles." Bulletin of Medical Sciences 94, no. 2 (2021): 88–96. http://dx.doi.org/10.2478/orvtudert-2021-0013.

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Abstract Benzimidazoles, which interfere with the complex life cycle of worms, are essential in the treatment of helminthiasis. Four benzimidazole antihelmintics have been used in human therapy: albendazole, mebendazole, thiabendazole, triclabendazole. The history, representatives, synthesis, physicochemical properties, structure-activity relationships of anthelmintic benzimidazoles are presented in the review, as well as the pharmacological properties and mechanism of action of these agents. In the last decade, benzimidazole carbamate-structured anthelmintics have also been studied for their

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Shelke, Pallavi Sitaram, Pradnya Nilesh Jagtap, and Prajakta Rohidas Tanpure. "In-vitro anthelmintic activity of Boswellia serrata and Aloe barbadensis extracts on Pheretima posthuma: Indian earthworm." International Journal of Research in Medical Sciences 8, no. 5 (2020): 1843. http://dx.doi.org/10.18203/2320-6012.ijrms20201939.

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Background: The development of anthelmintic resistance and the high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants as an alternative source of anthelmintics. In the current study, in- vitro experiments were conducted to determine the possible anthelmintic effects of crude aqueous and alcoholic extracts of the resins of Boswellia serrata and leaves of Aloe barbadensis on adult Indian earthworm (Pheretima posthuma).Methods: Various concentrations (50, 100, 150 mg/ml) of each extracts were tested and results were expressed in terms of time for paralysis and time

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Abongwa, Melanie, Richard J. Martin, and Alan P. Robertson. "A brief review on the mode of action of antinematodal drugs." Acta Veterinaria 67, no. 2 (2017): 137–52. http://dx.doi.org/10.1515/acve-2017-0013.

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Abstract Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since r

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Gudisa, Bereda. "Anthelmintic agents: vermicide and vermifuge." Insights in Biology and Medicine 6, no. 1 (2022): 001–8. http://dx.doi.org/10.29328/journal.ibm.1001020.

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Helminthiasis is also known as worm infection, is any macroparastic disease of humans and other animals in which a part of the body is infected with parasitic worms known as helminths. Anthelmintic agents are medicines that used for treatment and inhibition of parasitic infections caused by helminths; which involve both flat worms, such as, flukes and tapeworms and round worms, such as, nematodes. Anthelmintics are categorized into groups depending on the basis of their identical chemical structure and mode of action. Thiabendazole, mebendazole, and albendazole belong to benzimidazoles group o

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Mhlongo, Lindokuhle Christopher, Cresswell Mseleku, Thando Tenza, et al. "A Review of Ethnomedicinal Plants as Potential Anthelmintic Agents to Alternatively Control Gastrointestinal Nematodes of Ruminants in South Africa." Journal of Parasitology Research 2024 (January 16, 2024): 1–11. http://dx.doi.org/10.1155/2024/7955692.

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Small ruminant production is one of the most important animal productions for food security in the world, especially in the developing world. Gastrointestinal nematode (GIN) infection is a threat to this animal’s production. Conventional drugs that are used to control these parasites are losing their efficacy due to the development of resistant parasites. These drugs are not biologically degradable, taint meat products and are also expensive for communal farmers. Hence, research is now exploring ethnomedicinal anthelmintic plants for an alternative remedy. The objective of this paper was to re

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Malviya, Vedanshu. "Investigation of In-Vitro Antidiabetic Study, Antioxidant Activity and Anthelminthic Property of Various Extracts of Bitter Cumin Seeds." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 4 (2023): 6855–74. http://dx.doi.org/10.37285/ijpsn.2023.16.4.3.

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Background Bitter cumin (Centratherum anthelminticum (L.)) is a significant restorative plant. We examined the phenolic compounds, and antioxidants, hostile to hyperglycemic and anthelmintic properties of bitter cumin extracts in different in vitro models. Methods: Bitter cumin seeds were extracted with various solvents in their rising request of extremity, which incorporates chloroform, ethyl acetate, methanol, ethanol, and distilled water. The -amylase test and glucose take-up measure by yeast were used for the assessment of the antidiabetic property. Antioxidant agent acti

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Ahmad, Shahid. "PHYTOCHEMICALS AS ALTERNATIVE ANTHELMINTICS AGAINST POULTRY PARASITES: A REVIEW." Agrobiological Records 12 (June 2023): 34–45. http://dx.doi.org/10.47278/journal.abr/2023.015.

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Parasitic diseases causing considerable losses are one of the most common infections in humans, animals, and birds. This review emphasizes the devastation of the poultry industry by parasites and the use of bioactive components of plants as an alternative to control the damage. Synthetic medicines that are used in poultry as anthelmintic lead to the emergence of resistance in helminths as well as adversely affect birds and reduce their production. Different compounds are extracted from plants that show effective anthelmintic activity. Steroidal saponin alters the membrane permeability and inhi

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Martin, R. J. "Modes of action of anthelmintic drugs." Veterinary Journal 154, no. 1 (1997): 11–34. http://dx.doi.org/10.1016/s1090-0233(05)80005-x.

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Liu, Maoxuan, Sujogya Kumar Panda, and Walter Luyten. "Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes." Biomolecules 10, no. 3 (2020): 426. http://dx.doi.org/10.3390/biom10030426.

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Intestinal parasitic nematodes infect approximately two billion people worldwide. In the absence of vaccines for human intestinal nematodes, control of infections currently relies mainly on chemotherapy, but resistance is an increasing problem. Thus, there is an urgent need for the discovery and development of new anthelmintic drugs, especially ones with novel mechanisms of action. Medicinal plants hold great promise as a source of effective treatments, including anthelmintic therapy. They have been used traditionally for centuries and are mostly safe (if not, their toxicity is well-known). Ho

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Shanley, Harrison T., Tao Wang, Aya C. Taki, et al. "Advances in Anthelmintic Target Identification." International Journal of Molecular Sciences 26, no. 8 (2025): 3738. https://doi.org/10.3390/ijms26083738.

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Parasitic nematodes pose a significant threat to human and animal health, causing widespread morbidity and substantial socioeconomic losses globally. Despite the utility of anthelmintic drugs in parasite control, the emergence of widespread resistance necessitates the discovery of novel interventions. Advances through the use of whole-organism phenotypic screening have identified some promising nematocidal compounds, including nemacol, tolfenpyrad, UMW-9729, and ABX464. This article summarises efforts in this discovery, with a focus on Haemonchus contortus and Caenorhabditis elegans as model n

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Yempada, Praveena, Arya Lakshmi Marrisetti, and Ganga Rao Battu. "In silico, In vitro studies of Anti-Oxidant and Anthelminthic Abilities of Phytoconstituents from Rhynchosia cana (Wild.) DC." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 31, no. 1 (2022): 251–69. http://dx.doi.org/10.31351/vol31iss1pp251-269.

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Helminthiasis is a significant economic burden on grazing cattle. Increased resistance to currently available synthetic anthelmintics used to treat helminthiasis, and anthelmintic residues in meat and dairy products pose a significant worldwide health threat. These obstacles require the development of new anthelmintics capable of combating drug resistance while also exhibiting improved safety profiles. Rhynchosia cana (Fabaceae) is a herb that has historically been used as a worm expeller. To evaluate the phytochemical profile and explore the anti-oxidant and anthelmintic effects of different

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Bespalova, N. S., T. A. Zolotykh, and E. O. Vozgorkova. "Therapeutic Efficiency of Domestic Moxidectins in the Cases of Dog's Dirofilariosis." Russian Journal of Parasitology 12, no. 3 (2018): 82–86. http://dx.doi.org/10.31016/1998-8435-2018-12-3-82-86.

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The purpose of the research is to determine the therapeutic efficiency of the moxidectin-based domestic anthelmintics and develop protocol of medical and preventive activities in dog's dirofilariasis under the conditions of Central Black Earth Region of Russia. Materials and methods. Blood from ill dogs infected naturally with both species of dirofilariases that was tested for presence of helminths' larvae by Millipore® (Ireland) membrane filter method served as the material for the research. Experimental groups were formed out of 76 infected with dirofilariasis dogs aged 1-14 years under the

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Jayawardene, K. L. T. Dilrukshi, Enzo A. Palombo, and Peter R. Boag. "Natural Products Are a Promising Source for Anthelmintic Drug Discovery." Biomolecules 11, no. 10 (2021): 1457. http://dx.doi.org/10.3390/biom11101457.

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Parasitic nematodes infect almost all forms of life. In the human context, parasites are one of the major causative factors for physical and intellectual growth retardation in the developing world. In the agricultural setting, parasites have a great economic impact through a reduction in livestock performance or control cost. The main method of controlling these devastating conditions is the use of anthelmintic drugs. Unfortunately, there are only a few anthelmintic drug classes available in the market and significant resistance has developed in most of the parasitic species of livestock. Ther

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Shuchi, Dave, Vishwakarma Urmila, Rai Gopal, Baghel Uttam Singh, and Kumar Prashant. "In Vitro Anthelmintic Activity of Crude Extracts of Melissa Officinalis Against Pheretima Posthuma." Biosciences Biotechnology Research Asia 21, no. 4 (2024): 1665–70. https://doi.org/10.13005/bbra/3334.

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ABSTRACT: Aims: A literature review indicated that there isn't a single scientific study on the anthelmintic properties of the aerial part of Melissa officinalis. The study's main aim is to determine the anthelmintic activity of fresh juice extract, methanolic extract, and volatile oil extract of Melissa officinalis using Pheretima Posthuma as a test worms’ method. Method and materials: The concentrations of the fresh juice extract, methanolic extract, and volatile oil extract of Melissa officinalis Linn. are 10 mg/ml, 20 mg/ml, 30 mg/ml, 40 mg/ml, and 50 mg/ml. Every extract was examined to a

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LECOVÁ, L., L. STUCHLÍKOVÁ, L. PRCHAL, and L. SKÁLOVÁ. "Monepantel: the most studied new anthelmintic drug of recent years." Parasitology 141, no. 13 (2014): 1686–98. http://dx.doi.org/10.1017/s0031182014001401.

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SUMMARYMonepantel (MOP), a new anthelmintic drug from a group of amino-acetonitrile derivatives, has been intensively studied during last years. Many authors examined this new drug from different perspectives, e.g. efficacy against different species and stages of parasites, mode of action, metabolism, pharmacokinetics, toxicity, resistance, ecotoxicity, etc. MOP is an anthelmintic for livestock (currently only sheep and goats), with molecular mode of action which is different to all other anthelmintics. MOP has a broad-spectrum of activity against gastrointestinal nematodes of sheep, including

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Jackson, Catherine A., Elise L. McKean, and John M. Hawdon. "Differential Emodepside Efficacy in Drug-Resistant and Drug-Susceptible Ancylostoma caninum Highlights Variability in Potassium Channel Activity." Tropical Medicine and Infectious Disease 10, no. 7 (2025): 181. https://doi.org/10.3390/tropicalmed10070181.

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Multi-anthelmintic resistance in hookworms poses a significant challenge to both human and veterinary health, underscoring the need for novel treatment strategies. In this study, we evaluated the in vitro efficacy of three anthelmintics—pyrantel, ivermectin, and emodepside—against L3 larvae of drug-susceptible (WMD) and triple-anthelmintic-resistant (BCR) isolates of Ancylostoma caninum. While pyrantel was largely ineffective and ivermectin induced high mortality in both isolates, emodepside displayed a surprising trend: the drug-resistant BCR isolate was more susceptible than the drug-suscept

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PATHAK, K. M. L., and M. B. CHHABRA. "Medicinal plants as alternative to anthelmintics for livestock : An overview with particular reference to Indian subcontinent." Indian Journal of Animal Sciences 84, no. 4 (2014): 335–49. http://dx.doi.org/10.56093/ijans.v84i4.39822.

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In livestock farming helminthiasis remains a major constraint to productivity, performance and profitability. Anthelmintics have been in use since long to combat the problem, but the emergence of anthelmintic resistance, particularly in gastrointestinal (g.i.) parasites has compelled a relook at alternative control strategies. The application of ethno-veterinary practices and plant derivatives as deworming agents is gaining popularity worldwide. The acceptability of this approach depends on the scientific validation of the plant products for their anthelmintic properties. Several controlled st

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Rosli, Kasah Syahirah Shahlehi Mark I.R. Petalcorin Mohamed M.M. Najim Osumanu Haruna Ahmed Liza Nuriati Lim Kim Choo Shamsiah Sekot. "Potential anthelminthic properties of selected medicinal plants in Brunei Darussalam: a phytochemical review." Journal of Wildlife and Biodiversity 8, no. 3 (2024): 88–110. https://doi.org/10.5281/zenodo.11181258.

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Parasitic infections caused by nematode parasites are a challenge which causes significant threats to animal health, which results in economic losses. Medicinal plants have been utilised for generations as traditional remedies against various diseases due to the presence of bioactive compounds in the plants. This article reviews four selected plant species in Brunei: <em>Azadirachta indica</em>, <em>Andrographis paniculata</em>, <em>Clitoria ternatea,</em> and <em>Litsea elliptica</em> to unravel their potential in combating helminthic infections, considering both their historical significance

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Kanifnath, Nanvare* Samruddhi Rajpure Ulka Mote. "Anti-Helminthic Syrup by Herbal Extract." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1130–40. https://doi.org/10.5281/zenodo.15355115.

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Helminthiasis is a most common parasitic infection in the world. It may produce a serious risk to public health. Anthelmintic activity in paediatrics refers to use of drugs to treat parasitic worm infections in children. The various types of marketing preparations are available in the market. Finding innovative anthelmintics with a unique mode of action is imperative as a side effect and developing resistance to already prescribed anthelmintic medication pose a serious threat. Hence, the current study was carried out with aim to prepare and evaluate the anthelmintic activity with pineapple ext

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Шняк, E. Shnyak, Кедик, et al. "Prolonged forms of anthelmintic drugs." Russian Journal of Parasitology 3, no. 4 (2016): 539–46. http://dx.doi.org/10.12737/23080.

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Purpose of the research — to conduct analysis of the status and perspective of application of prolonged forms of anthelmintic drugs in veterinary. Materials and methods. On the topic of development and application of prolonged forms of anthelmintic in veterinary was conducted the analysis of 27 literature sources including 23 foreign authors. Were analyzed the data about kinetics of avermectins and praziquantel in the animals body and comparative results about dependence and correlation of pharmacokinetic parameters with their anthelmintics efficiency. The results and discussion. P

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Evarist Asiimwe, Erick Nyakundi Ondari, Grace Akinyi Odongo, and Ronald Kyobe Kimanje. "Determination of phytochemicals and anthelmintic activity of Rytigynia kigeziensis Verdc extracts using Eudrilus eugeniae model." World Journal of Advanced Research and Reviews 17, no. 3 (2023): 147–56. http://dx.doi.org/10.30574/wjarr.2023.17.3.0320.

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Helminthic infections are among the global public health problems. Due to high cost of standard drugs and resistance, rural dwellers use herbal preparations. However, efficacy and mechanisms of action remains elusive. In Uganda, Rytigynia kigeziensis is one of the commonly used anthelmintic herbs. The current study sought to determine the effect of phytochemicals in R. kigeziensis from the stem bark against E. eugeniae model for application as anthelmintic. The anthelmintic activity was carried out by time of paralysis and time of death at various at concentrations (15, 25, 50 and 100 mg/ml).

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Evarist, Asiimwe, Nyakundi Ondari Erick, Akinyi Odongo Grace, and Kyobe Kimanje Ronald. "Determination of phytochemicals and anthelmintic activity of Rytigynia kigeziensis Verdc extracts using Eudrilus eugeniae model." World Journal of Advanced Research and Reviews 17, no. 3 (2023): 147–56. https://doi.org/10.5281/zenodo.8123247.

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Helminthic infections are among the global public health problems. Due to high cost of standard drugs and resistance, rural dwellers use herbal preparations. However, efficacy and mechanisms of action remains elusive. In Uganda, <em>Rytigynia kigeziensis</em> is one of the commonly used anthelmintic herbs. The current study sought to determine the effect of phytochemicals in <em>R. kigeziensis</em> from the stem bark against E. eugeniae model for application as anthelmintic. The anthelmintic activity was carried out by time of paralysis and time of death at various at conce

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Bibik, Nacheva, Grebenshchikov, Nesterok, and Dodonov. "BASES FOR METHODOLOGICAL APPROACHES TO FORECASTING OF PATHOGENESIS PROCESSES IN THE TREMATODE BODY AFTER ANIMAL CHEMOTHERAPY." THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL, no. 21 (May 29, 2020): 57–62. http://dx.doi.org/10.31016/978-5-9902341-5-4.2020.21.57-62.

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The prospect of effective deworming is associated with the study of the mechanism of action of anthelmintics on helminths, its organs and tissues. The long-term use of methodological approaches using histological, histochemical and morphometric methods for studying organs and tissues of different types of trematodes (fascioli, euritrem, opisthorchia, dicrocelia, paramphistoma, etc.) after the anthelmintics action is effective, since it allows you to establish the mechanism and drug action on helminths. Using these methods, morphophysiological shifts were identified in the organs and tissues of

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Liu, Maoxuan, Jing-Guang Lu, Ming-Rong Yang, Zhi-Hong Jiang, Xiaochun Wan, and Walter Luyten. "Bioassay-Guided Isolation of Anthelmintic Components from Semen pharbitidis, and the Mechanism of Action of Pharbitin." International Journal of Molecular Sciences 23, no. 24 (2022): 15739. http://dx.doi.org/10.3390/ijms232415739.

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Parasitic helminths continue to pose problems in human and veterinary medicine, as well as in agriculture. Semen pharbitidis, the seeds of Pharbitis nil (Linn.) Choisy (Convolvulaceae), is a well-known traditional Chinese medicinal botanical preparation widely used for treating intestinal parasites in China owing to its desirable efficacy. However, the anthelmintic compounds in Semen pharbitidis and their mechanism of action have not been investigated yet. This study aimed to identify the compounds active against helminths from Semen pharbitidis, and to establish the mechanism of action of the

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Gorbatov and Chulkina. "ANTHELMINTIC FOR MIXED PARASITOSIS." THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL, no. 23 (April 18, 2022): 135–41. http://dx.doi.org/10.31016/978-5-6046256-9-9.2022.23.135-141.

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The antiparasitic program, which provides specific treatment and prevention regimens for fascioliasis, dictyoculosis, strongylatosis of the gastrointestinal tract and other parasitoses is the most effective link aimed primarily at removing helminths and preventing infection. Taking into account the total economic damage when helminthofauna in animals is represented simultaneously by parasitic species, it is necessary to be armed with anthelmintics of a wide spectrum of action. With their help, it is possible to carry out preventive measures most effectively and forced deworming, taking into ac

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Dye-Holden, L., and R. J. Walker. "Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action?" Parasitology 101, no. 2 (1990): 265–71. http://dx.doi.org/10.1017/s0031182000063320.

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The mechanism underlying the ability of the anthelmintic avermectin to paralyse the nematode Ascaris is not yet fully understood. Using conventional two-electrode electrophysiological recording techniques we have demonstrated that micromolar concentrations of ivermectin block the inhibitory GABA response on the muscle cells of the parasitic nematode Ascaris. The ability of a number of avermectin derivatives to act as receptor antagonists for the Ascaris muscle GABA receptor has been determined. This provides useful information to compare with the in vivo anthelmintic potency of these compounds

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MARTIN, R. J., and A. P. ROBERTSON. "Electrophysiological investigation of anthelmintic resistance." Parasitology 120, no. 7 (2000): 87–94. http://dx.doi.org/10.1017/s0031182099005715.

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It is pointed out that two of the three major groups of anthelmintic act by opening membrane ion-channels. It is appropriate, therefore, to use electrophysiological methods to study the properties of the sites of action of these drugs and the changes in the properties of these receptor sites associated with resistance. This paper describes the use of the patch- clamp technique to observe the currents that flow through the levamisole-activated channels as they open and close in levamisole-sensitive and levamisole-resistant isolates. It was found that, on average, the proportion of time the chan

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Emelyanova, Nadezhda B., Olga P. Kurnosova, and Mikhail V. Arisov. "Herbal Remedies with Anthelmintic Action. Myth or Reality." Russian Journal of Parasitology 13, no. 3 (2019): 82–87. http://dx.doi.org/10.31016/1998-8435-2019-13-3-82-87.

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Köhler, Peter. "The biochemical basis of anthelmintic action and resistance." International Journal for Parasitology 31, no. 4 (2001): 336–45. http://dx.doi.org/10.1016/s0020-7519(01)00131-x.

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Klyueva, A. K., A. A. Deltsov, and K. O. Belova. "The current state of the pharmaceutical market for anthelmintic drugs for veterinary use." Veterinariya, Zootekhniya i Biotekhnologiya 1, no. 9 (2021): 37–44. http://dx.doi.org/10.36871/vet.zoo.bio.202109005.

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This paper presents an analysis of the range of veterinary medicines registered in the territory of the Russian Federation and used for the prevention and treatment of helminthiasis. The Russian Federation is a leader in the development and production of anthelmintic medicines registered on its territory. Antiparasitic medicines used for the prevention and treatment of helminthiasis are divided according to the spectrum of action depending on the class of helminths. It was revealed that the majority of medicines (89 medicines – 58,17%) have a wide spectrum of action. Of these, 62 medicines (40

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Kumar, Neeraj, Sapna Chaudhar, Bhawani Shankar Verma, et al. "Design, Synthesis, And Biological Activity Of Some Novel Quinoline Derivatives." Journal of Neonatal Surgery 14, no. 7 (2025): 662–69. https://doi.org/10.63682/jns.v14i7.6078.

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Here, some novel quinoline derivatives are presented in an effort to synthesise some molecules with strong antioxidant activity. First, 7-methyl or 8-methyl substituted 2-cholro-3-formylquinolines (Ia, b) were made utilising the Vilsemeir-Hack reagent method. Additional substitutions of 7-methyl or 8-methyl Compound (I) reacted with 4M HCl upon microwave irradiation to produce 2-hydroxy quinoline-3-carbaldehyde (IIa, b). Subsequent treatment with various substituted hydrazides produced the new Schiff bases of quinoline III (a-f). TLC and melting point were used to assess the synthesised compou

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Shanley, Harrison T., Aya C. Taki, Joseph J. Byrne, et al. "A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity." Pharmaceuticals 15, no. 2 (2022): 257. http://dx.doi.org/10.3390/ph15020257.

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Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus contortus, are particularly important. The excessive use of anthelmintic compounds to treat infections and disease has led to widespread resistance to these compounds in nematodes, such that there is a need for new anthelmintics with distinctive mechanisms of action. With a focus on discovering new anthelmintic entities, we screened 400 chemically diverse compounds within the ‘Pandemic Response Box’ (from Medicines fo

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Tiwari, Sarika, Shweta Dixena, Monika Jain, Niharika Tiwari, and Vibhor Jain. "Pharmacognostical, Phytochemical and In-Vitro Anthelmintic Activity of Cassia roxburghii Seed and Boerhaavia diffusa Root against Pheritima posthuma Model." Journal of Drug Delivery and Therapeutics 12, no. 6-S (2022): 96–101. http://dx.doi.org/10.22270/jddt.v12i6-s.5711.

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Plants have served human beings as a natural source for treatments and therapies from ancient times, amongst them medicinal herbs have gain attention because of its wide use and less side effects. In the recent years plant research has increased throughout the world and a huge amount of evidences have been collected to show immense potential of medicinal plants used in various traditional systems. The objective of this study was to investigate pharmacognostical, phytochemical features and anthelmintic action of Cassia roxburghii (seeds) and Boerhaavia diffusa (roots). The different pharmacogno

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Kauerová, Tereza, María-Jesús Pérez-Pérez, and Peter Kollar. "Salicylanilides and Their Anticancer Properties." International Journal of Molecular Sciences 24, no. 2 (2023): 1728. http://dx.doi.org/10.3390/ijms24021728.

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Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most l

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Manjusha, Wath, Lakade Payal, and Lande Pritee. "COMPARATIVE EVALUATION OF ANTHELMINTIC ACTIVITY OF TWO PLANTS FROM THE FAMILY EUPHORBIACEAE." Biolife 2, no. 2 (2022): 534–37. https://doi.org/10.5281/zenodo.7206487.

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<strong>ABSTRACT</strong>   The anthelmintic activities of aqueous, methanolic and acetone extract of <em>Acalypha indica </em>L. and <em>Euphorbia hirta </em>L. belong to the family Euphorbiaceae were evaluated separately on Indian adult earthworm <em>Pheretima  posthuma</em> (Annelida). Extracts were prepared using soxhlet extraction and crude extract preparation methods with various concentrations (10, 25 and 50 mg/ml). Each extracts were tested in the bioassay, which involved determination of time of paralysis and time of the death of the worms. All extract were able to show anth

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Kalugina, E. G., and O. A. Stolbova. "Assessment of anthelmintic costs to control helminthosis in horses." Russian Journal of Parasitology 19, no. 2 (2025): 210–17. https://doi.org/10.31016/1998-8435-2025-19-2-210-217.

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The purpose of the research is to assess and economically justify the use of anthelmintics against helminthosis in horses.Materials and methods. The activity of the anthelmintic action of drugs against helminthosis in horses was studied, and a comparative analysis and cost calculation were performed in 2017 to 2025. One hundred and seventy-six Orlov, Russian trotting, Trakehner, Budyonny, Akhal-Teke, English Sport and local horses of different age and gender category, use, and type were examined. The results were processed statistically using Statistica 6.1 and Microsoft Excel software.Results

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Velmurugan, Aravinth, Keerthana Chandramohan, Ganeshan Thamizhselvan, et al. "Phytochemical Study, Evaluation of Antihelminthic Potential and In silico Screening for Breast Cancer Using Mimosa pudica Linn." Journal of Pharmaceutical Research International 36, no. 6 (2024): 135–43. http://dx.doi.org/10.9734/jpri/2024/v36i67529.

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Breast Cancer is a major health concern in India, where it is highly lethal for women because of unchecked cell proliferation and metastasis, which are frequently caused by interactions between the Estrogen Receptor Alpha and other receptors. Even though they work well, synthetic Anthelmintics come with dangers to the health of both humans and animals. Therefore, creating effective and safe Anthelmintics from plant sources is our main goal. We extracted Mimosa pudica leaves with ethanol using a Soxhlet system, and after concentration, we examined the extract using GC-MS, FTIR, and UV technique

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N., Deepa. "An Overview of Medicinal Plants with Anthelmintic Properties." International Journal of Pharmacy and Biological Sciences (IJPBS) 14, no. 3 (2024): 66–71. https://doi.org/10.5281/zenodo.14167393.

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AbstractHelminth parasite diseases are widespread and induce a variety of clinical problems as well as long-term and irreversible morbidity in humans. Despite significant advancements in the medical sciences, the efficacy of currently available anthelmintics remains rather low. In addition to being comparatively side effect-free, modern synthetic medications are highly effective at curing illnesses. Many medicinal herbs that are used by ethnic groups all over the world are also said to have anthelmintic properties in traditional systems of medicine. Several medicinal plants have been investiga

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Scott-Baird, E., C. Leifert, S. A. Edwards, and G. Butler. "Effects of an algal biomass supplement on the periparturient rise in nematode egg output from ewes and the subsequent effects on their offspring." Proceedings of the British Society of Animal Science 2007 (April 2007): 96. http://dx.doi.org/10.1017/s1752756200019992.

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The periparturient rise in nematode eggs at lambing is a crucial part of the epidemiology of nematode infections as it allows a large number of infective larvae to be present in the pastures when the lamb is young and most immunologically naïve. With a rapidly rising level of anthelmintic resistance and increasing public concern over drug residues remaining in animal products, it is necessary to achieve more long-term, sustainable nematode control programmes. Some plant products could provide alternatives or adjuncts to conventional control with anthelmintics and ease the selection pressure fo

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Mordvinov, Viatcheslav, and Maria Pakharukova. "Xenobiotic-Metabolizing Enzymes in Trematodes." Biomedicines 10, no. 12 (2022): 3039. http://dx.doi.org/10.3390/biomedicines10123039.

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Trematode infections occur worldwide causing considerable deterioration of human health and placing a substantial financial burden on the livestock industry. The hundreds of millions of people afflicted with trematode infections rely entirely on only two drugs (praziquantel and triclabendazole) for treatment. An understanding of anthelmintic biotransformation pathways in parasites should clarify factors that can modulate therapeutic potency of anthelmintics currently in use and may lead to the discovery of synergistic compounds for combination treatments. Despite the pronounced epidemiological

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PRCHAL, LUKÁŠ, HANA BÁRTÍKOVÁ, ANETA BEČANOVÁ, et al. "Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa." Parasitology 142, no. 5 (2014): 648–59. http://dx.doi.org/10.1017/s0031182014001711.

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SUMMARYThe sheep tapeworm Moniezia expansa is very common parasite, which affects ruminants such as sheep, goats as well as other species. The benzimidazole anthelmintics albendazole (ABZ), flubendazole (FLU) and mebendazole (MBZ) are often used to treat the infection. The drug-metabolizing enzymes of helminths may alter the potency of anthelmintic treatment. The aim of our study was to assess the activity of the main drug-metabolizing enzymes and evaluate the metabolism of selected anthelmintics (ABZ, MBZ and FLU) in M. expansa. Activities of biotransformation enzymes were determined in subce

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Krücken, Jürgen, Achim Harder, Peter Jeschke, et al. "Anthelmintic cyclooctadepsipeptides: complex in structure and mode of action." Trends in Parasitology 28, no. 9 (2012): 385–94. http://dx.doi.org/10.1016/j.pt.2012.06.005.

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SJ, Aditya R., Ramesh CK, Raghavendra S, and Paramesha M. "Dehydroabietylamine, A Diterpene from Carthamus tinctorious L. Showing Antibacterial and Anthelmintic Effects with Computational Evidence." Current Computer-Aided Drug Design 16, no. 3 (2020): 231–37. http://dx.doi.org/10.2174/1573409915666190301142811.

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Background: Plant-based drugs provide an outstanding contribution to modern therapeutics, and it is well known that the presence of different phytochemicals is responsible for such pharmacological effects. Carthamus tinctorius L. is one such medicinally important plant whose different solvent extracts have been reported with several pharmacological effects like antibacterial, hepatoprotective, and wound healing. The exploration of phytoconstituents from such a medicinally important plant for different pharmacological effects could produce new and effective drugs to treat human diseases. Object

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