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Dissertations / Theses on the topic 'Anthelmintic drug'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Stenhouse, Lindsay Joanne. "Characterisation of anthelmintic resistance in a multiple drug resistant Teladorsagia circumcinta isolate." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/4251/.

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The purpose of this study was to undertake detailed molecular and phenotypic characterisation of a MDR isolate of T. circumcincta (MTci5) with particular focus upon the mechanisms underlying benzimidazole (BZ) resistance. MTci5 was isolated from a farm in Central Scotland, which employed a suppressive anthelmintic dosing regime and was closed in 2002 when control of the parasite population became unsustainable. Underpinning all of the experiments in this study was an anthelmintic selection process whereby the MTci5 isolate was pressured individually with three broad-spectrum anthelmintics (b

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2

Kenealy, Jessica Scare. "ANTHELMINTIC RESISTANCE IN EQUINE PARASITES: MECHANISMS AND TREATMENT APPROACHES." UKnowledge, 2019. https://uknowledge.uky.edu/gluck_etds/40.

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Anthelmintic resistance of parasites infecting livestock animals is a global problem resulting in decreased animal welfare and production losses. Horses are not exempt from this issue as wide-spread anthelmintic resistance exists among the equine cyathostomins and Parascaris spp. Of the three drug classes available for treating equine intestinal helminths anthelmintic resistance, defined as less than 90-95% drug efficacy, exist to all three. New pharmaceutical control regimens and the elucidation of parasite drug response mechanisms are needed. Two studies were carried out evaluating combinati

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3

Blackhall, William James. "Genetic variation and multiple mechanisms of anthelmintic resistance in Haemonchus contortus." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37596.

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Anthelmintic treatment of livestock is an important aspect of the control of gastrointestinal parasites. Resistance to anthelmintics is common, and an understanding of resistance requires knowledge of an anthelmintic's mode(s) of action and mechanism(s) of resistance. The parasitic nematode, Haemonchus contortus, has developed resistance to benzimidazoles and avermectins/milbemycins. Proposed mechanisms of resistance are here supported by genetic changes observed in genes whose protein products are believed to interact with these anthelmintics. Statistically significant differences in allele f

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4

Njue, Annette Igandu. "Mechanisms of anthelmintic resistance in Cooperia oncophora, a nematode parasite of cattle." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84302.

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Anthelmintic resistance is a major problem in livestock, and while it has been slower to emerge in cattle, there are reports of its occurrence. Three broad-spectrum anthelmintics are available for use, and one mechanism of resistance that is common to all is target site alteration. Glutamate-gated chloride channels (GluCls) are an important target for macrocyclic lactone anthelmintics (MLs), while beta-tubulin represents the benzimidazole (BZ) target. The objectives of this thesis were to determine whether GluCls are involved in ML resistance in the cattle parasite Cooperia oncophora ,

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5

Masuka, Raban Wilfred. "Chemogenomic approaches to drug design : docking-based virtual screening of nematode GPCRs for potential anthelmintic agents." Doctoral thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20968.

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Among common problems affecting human health and veterinary medicines, helmintic infections are major. The pathogens affect 550-750 Million people worldwide, and affect childhood growth, pregnancies, and development of the intellect. Helminths affects the well-being of animals as well including livestock and reduce the animal populations. However, the current anthelmintics are no longer as effective and some strains have developed resistance thus increasing the need for new anthelmintics. Unfortunately, not too much information is available detailing the physiology of helminths. The published

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6

Kigen, Gabriel Kimutai. "Assessment of Drug Interactions Between Antiretroviral and the Anthelminthic drugs." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507508.

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7

Souhaili-El, Amri Hajar. "Albendazole : métabolisme et régulation des enzymes hépatiques du métabolisme des xénobiotiques." Nancy 1, 1988. http://www.theses.fr/1988NAN10122.

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8

Woolley, Ley Hwee. "Synthesis of potential anthelminthic drugs." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258257.

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9

Benchaoui, Hafid Abdelaali. "Factors affecting the pharmacokinetics, metabolism and efficacy of anthelmintic drugs." Thesis, University of Glasgow, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284569.

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10

Gokbulut, Cengiz. "Plasma disposition, faecal excretion, metabolism and chirality of anthelmintic drugs in horses." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323707.

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11

Pandarakalam, George Cherian. "Spliced leader trans-splicing : a target for the identification of novel anthelmintic drugs." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230533.

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12

Gelmedin, Verena Magdalena. "Targeting flatworm signaling cascades for the development of novel anthelminthic drugs." kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/3333/.

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13

Laing, Steven. "Caenorhabditis elegans as a model for nematode metabolism of the anthelmintic drugs ivermectin and albendazole." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1781/.

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Resistance to anthelmintics used to treat parasitic nematodes of veterinary importance represents a serious welfare and economic problem for the livestock production industry. Research into the mechanisms by which parasites develop resistance is necessary to prolong the life of the available drugs and to minimise development of resistance to new classes. Metabolism of anthelmintic compounds by parasites is a possible mechanism of resistance that has received little research, despite there being precedence in the case of insecticide resistance. Due to the more advanced molecular tools available

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14

Levitt, Nancy. "Genetics of avermectin resistance in the nematode parasite Haemonchus contortus." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81357.

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The objectives of this study are to estimate the degree to which a glutamate-gated chloride channel gene (HcGluCla) contributes to survival of moxidectin treatment and to study the relative dominance of those alleles. The phenotype of individual adult H. contortus with respect to feeding was determined using an inulin uptake assay. Genotype was determined using a diagnostic PCR assay. In the absence of moxidectin, homozygous susceptible genotypes fed significantly more than homozygous resistant genotypes. The effect of the susceptible allele was dominant. In the presence of moxidectin,

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15

Galazzo, Daniel. "A comparison of laboratory and field resistance to macrocyclic lactones in Haemonchus contortus /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82236.

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Sustainable parasite control in livestock depends on anthelmintic drugs. The nematode Haemonchus contortus, the most important intestinal parasite of sheep and goats has developed resistance to all classes of anthelmintics including moxidectin, the most potent of the macrocyclic lactones. Pyrosequencing was used to screen H. contortus laboratory and field strains for single nucleotide polymorphisms (SNPs) associated with resistance in three genes, and determine their involvement in field resistance to macrocyclic lactones. Specific SNPs increased in frequency in ivermectin/moxidectin la

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16

Dimah, Al Shehnah. "Egg hatching protocol and an in vitro scoring system in Parascaris univalens larvae after exposure to anthelmintic drugs." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425456.

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A scaris is a genus of parasitic worms (helminths) found in the small intestine of various mammalian hosts, including Ascaris lumbricoides in humans, Parascaris equorum and P univalens in horses, Ascaris suum in pigs, Toxocara cati in cats and Toxocara canis in dogs. To date, Parascaris spp. are the only Ascaris worms that have developed resistance to anthelmintic drugs. The mechanisms of resistance in Parascaris spp are incompletely understood, partly due to the absence of robust in-vitro models. Further complicating in-vitro studies, Parascaris spp lack a free-living larval stage as their la

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17

Menkir, Mekonnen Sissay. "Helminth parasites of sheep and goats in Eastern Ethiopia : epidemiology, and anthelmintic resistance and its management /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200752.pdf.

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18

Fischer, Juliane Katharina [Verfasser]. "A Study on the Efficacy of selected Anthelmintic Drugs against Cyathostomins in Horses in the Federal State of Brandenburg, Germany / Juliane Katharina Fischer." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/107549365X/34.

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19

EL-Dosoky, Mohammed Mohammed Ahmed [Verfasser], and Robert [Akademischer Betreuer] Kreuzig. "Environmental Chemical Analysis Related to Drug Industries: Method Development for the Analysis of Benzimidazole Anthelmintics and Corresponding Metabolites in Liquid Pig Manure and Manured Soil / Mohammed Mohammed Ahmed EL-Dosoky ; Betreuer: Robert Kreuzig." Braunschweig : Technische Universität Braunschweig, 2012. http://d-nb.info/1175824399/34.

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20

N'Guessan, Déto. "Conception, synthèse et évaluation des activités anthelminthiques de nouvelles molécules à support imidazo (1,2-a) pyridine." Thesis, Tours, 2017. http://www.theses.fr/2017TOUR3802.

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Les strongyloses vétérinaires constituent l’une des principales causes de gastroentérites et d’anémie des ovins et caprins à l’origine de lourdes pertes économiques. Cependant, leurs prise en charge par les anthelminthiques existants, est confrontée à la prolifération d’une pharmacorésistance des nématodes incriminés. La première partie de ce travail de thèse présente l’ampleur du problème que pose la résistance des helminthes impliqués dans les strongyloses des petits ruminants. Elle révèle également le profil novateur des imidazo[1,2-a]pyridinyl-phénylacrylonitriles qui est proposé pour pare

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21

Štefanová, Anna. "Vliv anthelmintik na transport léčiv ve střevě." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-446493.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Bc. Anna Štefanová Supervisor: PharmDr. Ivan Vokřál, Ph.D. Title of diploma thesis: Effect of anthelmintics on the transport of drugs in the intestine Several classes of drugs are currently available for the treatment of helminthiasis in humans and animals, the so-called anthelmintics. Most of these drugs are administered by the oral route, where absorption into the systemic circulation occurs through the intestinal barrier. However, the course and extent of this absorption may be limite

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22

Aremu, Adeyemi Oladapo. "Pharmacology and phytochemistry of South African plants used as anthelmintics." Thesis, 2009. http://hdl.handle.net/10413/561.

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Traditional medicine in South Africa is part of the culture of the people and has been in existence for a long-time. Although animal components form part of the ingredients used, plant material constitutes the major component. South Africa is endowed with vast resources of medicinal and aromatic plants which have been employed for treatment against various diseases for decades. A large number of South Africans still depend on traditional medicine for their healthcare needs due to its affordability, accessibility and cultural importance. Helminth infections are among the variety of diseases tre

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23

Gelmedin, Verena Magdalena [Verfasser]. "Targeting flatworm signaling cascades for the development of novel anthelminthic drugs / submitted by Verena Magdalena Gelmedin." 2009. http://d-nb.info/993190286/34.

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24

Τσιμπούκης, Δημήτριος. "Διερεύνηση των επιπέδων κτηνιατρικών ανθελμιθικών ουσιών στο γάλα και εκτίμηση της πρόσληψης από τον άνθρωπο". Thesis, 2013. http://hdl.handle.net/10889/6272.

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Σκοπός: Ο προσδιορισμός των επιπέδων συγκέντρωσης καταλοίπων κτηνιατρικών παρασιτοκτόνων ουσιών (ανθελμινθικών), σε νωπό γάλα μηρυκαστικών από περιοχές της Νοτίου Ελλάδος και η εκτίμηση της πρόσληψής τους από τον άνθρωπο. Συγκεκριμένα εξετάσθηκαν οι ουσίες, Albendazole, Febantel, Fenbendazole, Mebendazole και κάποιοι μεταβολίτες τους (Albendazole sulfoxide, Albendazole sulfone, Fenbendazole sulfone) στο νωπό γάλα προβάτων, αιγών και βοοειδών. Μέθοδοι: Χημική ανάλυση δειγμάτων γάλακτος, με τη βοήθεια Υγρής Χρωματογραφίας Υψηλής Απόδοσης και ανιχνευτή Συστοιχίας Διόδων, Υπεριώδους (UV). Χρήση β

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