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Dissertations / Theses on the topic 'Anthraquinone Derivative'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Alam, Zohaib. "Anti-Cytomegalovirus Activity of Atanyl Blue PRL, an Anthraquinone Derivative." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3166.

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Cytomegalovirus (CMV) is a significant cause of mortality and morbidity in immunocompromised patients and an important cause of birth defects if acquired in utero. The licensed CMV antivirals, ganciclovir, cidofovir and foscarnet, all target the viral DNA polymerase. For each drug prolonged use is associated with significant toxicities and development of drug resistance. None are approved for use during pregnancy. Therefore, development of new anti-CMV drugs that target different pathways would be beneficial. All herpesviruses encode an alkaline nuclease. That genetic disruption of the CMV alk

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2

Alaparthi, Madhubabu. "Molecular Recognition Involving Anthraquinone Derivatives and Molecular Clips." Thesis, University of South Dakota, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10285748.

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<p> In the past, we have demonstrated that 1,8-anthraquinone-18-crown-5 (1) and its heterocyclic derivatives act as luminescent hosts for a variety of cations of environmental and clinical concern. We report here a series of heteroatom-substituted macrocycles containing an anthraquinone moiety as a fluorescent signaling unit and a cyclic polyheteroether chain as the receptor. Sulfur, selenium, and tellurium derivatives of 1,8-anthraquinone-18-crown-5 (<b>1</b>) were synthesized by reacting sodium sulfide (Na<sub>2</sub>S), sodium selenide (Na<sub>2</sub>Se) and sodium telluride (Na<sub>2</sub>

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3

Argade, A. B. "Synthesis of biologically active anthraquinone derivatives via marschalk reaction." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1988. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3308.

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4

Abou-Elkhair, Reham A. I. "Synthesis of anthraquinone derivatives and their conjugates with 2'-deoxynucleosides as new probes for electron transfer studies in DNA." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-07182008-154942/.

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Thesis (Ph. D.)--Georgia State University, 2008.<br>Title from file title page. Thomas L. Netzel, Dabney W. Dixon, committee co-chairs; David Boykin, Jerry Smith, committee members. Electronic text (250 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Nov. 20, 2008. Includes bibliographical references.

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5

Ma, Jiani, and 马佳妮. "Time-resolved spectroscopic studies of meta methyl activation reaction of selected benzophenone and anthraquinone derivatives." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196012.

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Femtosecond time-resolved transient absorption (fs-TA), nanosecond time-resolved transient absorption (ns-TA), and nanosecond time-resolved resonance Raman spectroscopy (ns-TR3) methods were used to study the behaviors of the transient intermediates involved in the photophysical and photochemical processes of 3-methylbenzophenone (3-MeBP), 3-(hydroxymethyl)benzophenone (m-BPOH), and 2-(1-hydroxyethyl) 9,10-anthraquinone (2-HEAQ). A particular focus of this work was to study the unusual meta methyl activation reactions of these compounds in water-containing solutions. Density functional theor

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6

Ezenwafor, E. I. I. "The synthesis and properties of derivatives of 1-amino-4-hydroxy anthraquinone : The synthesis of thiolated derivatives of 1-amino-4-hydroxy anthraquinone and a study of their application, dyeing and fastness properties on synthetic-polymer fibres." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371494.

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7

Cao, Yu. "I. Synthesis Of Anthraquinone Derivatives For Electron Transfer Studies In DNA. II. Characterization Of The Interaction Between Heme And Proteins." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/55.

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Anthraquinone (AQ) derivatives with relatively high reduction potentials have been synthesized to afford good candidates for electron transfer studies in DNA. Electron withdrawing groups on the anthraquinone ring gave derivatives with less negative reduction potentials. The anthraquinone imide (AQI) derivatives had reduction potentials less negative than AQ derivatives. The AQI ring system was subject to base-induced hydrolysis. Water-soluble sulfonated tetraarylporphyrins have been studied in a wide variety of contexts. Herein, we report the first synthesis of a pentasulfonated porphyrin

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8

Oliveira, Larissa Albuquerque de. "Preparação, caracterização e avaliação de novos análogos da mitoxantrona com potenciais atividades biológicas." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/5893.

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9

HSU, CHIN-CHIA, and 許晉嘉. "The Role of SIRT1 in Regulating Chemoresistance of a Novel Anthraquinone Derivative in Prostate Cancer Cells." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/9u6xw4.

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碩士<br>慈濟大學<br>生命科學系碩士班<br>105<br>SIRT1, the mammalian homologue of the silent information regulator 2 (Sir2) gene which belongs to the family of type III histone deacetylase, is implicated in diverse cellular processes including cell survival under genotoxic and oxidative stresses. SIRT1 expression is correlated with cell growth, as well as the chemoresistance, and is markedly up-regulated in androgen-refractory prostate cancer PC3 cells. SIRT1-induced autophagy is known to occur at the level of autophagosome maturation and completion in cultured prostate cancer cells. To identify novel small

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10

Wei-Ren, Jeng, and 鄭維仁. "Synthesis and Bioactivity Evaluation of 1,5-Bis-acyloxy-anthraquinone and 1,5-Bis-thio-substituted Anthraquinone Derivatives." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/03785161358076035167.

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碩士<br>國防醫學院<br>藥學研究所<br>89<br>We have synthesized 23 compounds of anthraquinone derivatives, which included 1,5-bis-acyloxy-anthraquinone and 1,5-bis-thio-substituted anthraquinone. We wish to choose more active compounds by cytotoxic tests and lipid-peroxidation tests. Now we have three compounds more active than mitoxantrone against Hepa G2 cells (about 5 to 85 times stronger), and they are compound 5b、5f、5m; in addition, one compound, 6a, is more active than mitoxantrone against C6 glioma cells (about > 3.5 times stronger). In the lipid-peroxidation test, we concluded that at 10 mM, compoun

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11

TENG, CHI-HUNG, and 鄧志煌. "Synthesis and Activities of 1,3-Dihydroxy-9,10-anthraquinone Derivatives." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/16449323228849501668.

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碩士<br>高雄醫學大學<br>藥學研究所<br>90<br>Apoptosis causes cell died for a mechanism of the balance of the human tissue growth, and compound that has the activity of the apoptosis may be developed as more specific anticancer agent. In some plants, natural anthraquinone isolated from plants and some synthetic 1,3- dihydroxyanthraquinones showed cytotoxicity due to apotosis. For a continual study on the cytotoxicities and antiplatelet effects of 1,3- dihydroxyanthraquinone derivates, we further synthesized 12 anthraquinone derivatives. 1,3-dihydroxy-4-prenyl-9,10-anthraquinone (5)、3,4-(2,2-dimethylpyrano)-

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12

Chen, Tsung-Chih, and 陳宗志. "Synthesis and Telomerase Inhibition of 1,2-Heteroannelated Anthraquinone Derivatives." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/74124876191629648316.

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碩士<br>國防醫學院<br>藥學研究所<br>95<br>Telomere is the nucleoprotein structure at the end of chromosomes consisting of guanine-rich tandem repeats of the sequence d(TTAGGG) in human. Because of the end replication problem, telomere is shortened by 50-60 bases whenever cell division happens, and this erosion induces apoptosis when its length became critically short. On the other hand, telomerase is active in 85-90% of human tumor cells, and this enzyme elongates telomeres by catalyzing the addition of telomere sequence, maintaining telomere length so that these cells are immortalized. Anthraquinone-base

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13

Szu-Hui, Wu, and 吳思慧. "Synthesis and Cytotoxic Effect of 1,3-Dihydroxy-9,10-Anthraquinone Derivatives." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/92284009079525620221.

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碩士<br>高雄醫學院<br>藥學研究所<br>87<br>Frangulin B, a cytotoxic anthraquinone, isolated from Rhamnus formosana, mediates its cytotoxicity through apoptosis. Cytotoxicity through apoptosis may be developed as more specific anticancer agents, a series of analogues of frangulin B have been synthesized and evaluated their cytotoxicity. In continued study of the structure-activity relationships of various anthraquinone derivatives and their design as anticancer drugs, we further synthesized 14 new anthraquinone derivatives, 1-hydroxy-3-[2,3-epoxypropoxy]-9,10-anthraquinone (5), l-hydroxy-3-[3-(chloro)-2-hyd

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14

Kuo, Daih-Huang, and 郭代璜. "Effects of Anthraquinone Derivatives on Small Intestinal Motility of Rabbit." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/05794024517035573942.

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博士<br>中國醫藥學院<br>藥物化學研究所<br>84<br>The effects of anthraquinone-2-carboxylate and anthraquinone-2-carboxamideson the motility of isolated rabbit small intestines was examined. It was found that some possessed concentration-dependent inhibitory activity. Comparisonof IC50 values revealed a requirement for a polar group, especially a hydroxygroup at B-1,2,5,8-tetrahydroxy and 3-methyl-1,6,8- trihydroxyl anthraquinoneinhibited the intestianl motility more potently than did the lead compound anth

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15

Guo, Dai Huang, and 郭代璜. "Effects of anthraquinone derivatives on small intestinal motility of rabbit." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/53538779221788698708.

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16

Chen, Rong-Fu, and 陳榮福. "Biological Evaluations and Structure Activity Relationships of Anthracene and Anthraquinone Derivatives." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/64184651816850797122.

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碩士<br>國立陽明大學<br>藥理學研究所<br>93<br>Emodin is a type of anthraquinone that is produced by plants. Free radical and reactive oxygene species (ROS) derived from it have the effects of immunity suppression, mutagenicity and cyto-toxicity. However, emodin is also an anti-oxidant and able to scavenger free radicals. Therefore it can be used as an anti-inflammatory agent or to suppress the lipid peroxidation. Sythesized anthraquinone such as doxorubicin is widely used to treat leukemia and breast cancer. But the semiquinone radical and ROS derived from doxorubicin, combined with nitric oxide (NO) genera

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17

彭明玲. "Synthesis of acetyl derivatives of anthraquinone by various methods were examined." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/72690481756278471309.

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18

CHEN, YI-LING, and 陳羿伶. "Effect of Anthraquinone Derivatives on the Chemoresistance of Prostate Cancer Cells." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/wuaqf2.

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碩士<br>慈濟大學<br>生命科學系碩士班<br>107<br>Prostate cancer is the second most frequent cancer and the sixth among the top ten cancer leading cause of death in men. An anthraquinone derivative, ANT, exhibits anticancer activity and elicits autophagy on prostate cancer cells in our previous study. Herein, we comparatively investigate the molecular mechanism of this novel compound on prostate cancer cells by PC-3 and DU145 cells. We found that the highly expressed SIRT1, a NAD+-dependent deacetylase of the Sirtuin family, was declined in both prostate cancer cells. To clarify the effects of ANT on autophag

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19

Calugi, Lorenzo. "Synthesis and characterisation of new glycoconjugated anthraquinone derivatives for application in textile and leather dyeing industry." Doctoral thesis, 2019. http://hdl.handle.net/2158/1156016.

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Nel lavoro di tesi sono stati sintetizzati alcuni derivati del cromoforo antrachinonico Disperso Violetto 17 (DV17) utilizzando reazioni di cross-coupling Palladio catalizzate (Suzuki, Heck e Sonogashira) per poter poi ottenere nuovi coloranti naturalizzati, ovvero coloranti resi solubili in acqua grazie alla glicoconiugazione con un derivato del lattosio sviluppato dal nostro gruppo di ricerca. Per il processo di glicoconiugazione sono necessarie due unità: un cromoforo opportunamente modificato per introdurre un gruppo carbossilico e una unità lattosio-piperazina protetto. L’introduzione del

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20

Tsai, Cheng-Chan, and 蔡政展. "Design, synthesize and evaluate anticancer activity of ketone and methyloxime containing anthraquinone derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/9gp87t.

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碩士<br>大仁科技大學<br>製藥科技研究所<br>104<br>Anthraquinone compounds, anthracyclines and anthracenediones, have long been used as effective anticancer drugs against a broad spectrum of tumours. Recently, we have prepared amide-containing anthraquinone and evaluated in vitro for their anti-proliferative activities against a panel of human cancer cell lines including nasopharyngeal (NPC-TW01), lung carcinoma (H661), leukemia (Jurkat). Among them, 2-(9,10-dioxo-9,10-dihydroanthracen-2-yloxy)-N-(naphthalen-2-yl)acetamidewas the most active and selective against NPC-TW01 with an IC50 value of 2.62 μM. On the

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21

WEI, MEI-JIN, and 魏玫津. "Synthesis and antiallergic activities of 6, or 7-substituted anthraquinone-2-carboxylic acid derivatives." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/02588238858474197205.

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22

LI, HUI, and 李輝. "Antimutagenicity of flavonoid and anthraquinone derivatives against IQ: structure-activity relationships and action mechanisms." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/65127826430625904572.

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23

Tu, Huang-Yao, and 涂皇堯. "Designs and Biological Studies of Ursolic Acid, Chalcone, and Anthraquinone Derivatives as Targeted Anticancer Agents." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/98036184556660519251.

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博士<br>高雄醫學大學<br>藥學研究所<br>98<br>Ursolic acid derivatives (2-24), chalcone derivatives (27-43 and 45), and anthraquinone derivatives (50-62) were synthesized, evaluated for cytotoxicities against cancer cell lines, and discussed their biological activities in this study. All these synthesized derivatives exhibited cytotoxicities against several cancer cell lines and were elucidated their structures and cytotoxic activity relationships. Among synthesized chalcone derivatives, compounds 37 and 41 with a 4-carbamoyl moiety showed potent cytotoxic activities against human bladder and prostate cancer

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24

Lee, Chia-Chung, and 李佳駿. "Synthesis and Biological Evaluation of Novel Asymmetrical 1,2-Disubstituted Amido-anthraquinone Derivatives as Anticancer Agents." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/28827155158844024958.

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碩士<br>國防醫學院<br>藥學研究所<br>97<br>Telomerase activity is an important biomarker for determining the proliferative capacity in cancer cells, which can be detected in ca. 85-90％ of the immortalized or tumor cells. Developments of anthraquinone-based compounds such as adriamycin and mitoxantrone as reference drug are attractive target for design of novel chemotherapeutic agents. We have synthesized a series of new symmetrical (identical side chains) or asymmetrical 1,2-diamido-anthraquinone derivatives (CC-01 – CC-50) with potentially anti-cancer activities have been synthesized. These compounds were

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25

Chen, Cing-Hua, and 陳慶樺. "Design, synthesize and evaluate De Novo anticancer agents with oxime and methyloxime containing anthraquinone derivatives." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/x94e34.

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碩士<br>大仁科技大學<br>藥學系碩士班<br>107<br>Anthraquinone compounds, anthracyclines and anthracenediones, have long been used as effective anticancer drugs against a broad spectrum of tumors. Recently, we have prepared oxime and methyloxime-containing anthraquinone derivatives and evaluated in vitro for their anti-proliferative activities against a panel of human cancer cell lines including nasopharyngeal (NPC-TW01), lung carcinoma (NCI-H266), leukemia (Molt4), lymphoid (Sup-T1) and prostate adenocarcinoma (PC-3). Among them, methyloxime-containing anthraquinone derivatives exhibited active against NCI-H

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26

Liang, Yachun, and 梁雅淳. "Investigation of some selected anthraquinone derivatives as potential PARP inhibitors in lung cancer cells and nuclear reprogramming." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/03400329543827269587.

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碩士<br>國防醫學院<br>藥學研究所<br>99<br>The abundant nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1), a multifunctional regulator of chromatin structure and DNA repair. High expression of PARP-1 has been indicated in several cancer types, so inhibitors of PARP-1 might be effective as therapeutic agents for the treatment of tumors. Germline mutations in the genes BRCA sensitize breast cancer cells to PARP inhibitors in a PARP-1-dependent manner. BRCA mutation also has been observed in non-small-cell lung cancers (NSCLCs). We screen and develop some lead compounds with anthraquinone-based pharmacop

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27

Teesdale-Spittle, P. H., Klaus Pors, R. Brown, Laurence H. Patterson, and J. A. Plumb. "Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells." 2005. http://hdl.handle.net/10454/3191.

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No<br>A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-difluoro-5,8-dihydroxyanthraquinones by hydroxylated piperidinyl- or pyrrolidinylalkyl-amino side chains. One aminoanthraquinone (13) was further derivatized to a chloropropyl-amino analogue by treatment with triphenylphosphine-carbon tetrachloride. The compounds were evaluated in the A2780 ovarian cancer cell line and its cisplatin-resistant variants (A2780/ cp70 and A2780/MCP1). The novel anthraquinones were shown to possess up to 5-fold increased potency against the cisplatin-resistant ce

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28

李輝. "1.Detection of Cooked-Food Mutagens in Canned Foods and Boiled Pork Juice Model System and Their Mechanisms of Mutagen Formation 2.Antimutagenicity of Flavonoid and Anthraquinone Derivatives Against IQ: Structure-Activity Relationships." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/59677271695486541528.

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29

Pors, Klaus, Z. Paniwnyk, Laurence H. Patterson, K. C. Ruparelia, J. A. Hartley, and L. R. Kelland. "Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells." 2004. http://hdl.handle.net/10454/3164.

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No<br>Novel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating properties along with their respective hydroxyethylaminoanthraquinone intermediates were synthesized. Selected chloroethylaminoanthraquinones were shown to cross-link DNA and alkylate guanines (at low nM concentration) with a preference for reaction sites containing 5'-PyG. A compound (Alchemix) with the bis-chloroethyl functionality confined to one side chain alkylated but did not cross-link DNA. All the 1,4-disubstituted chloroethylaminoanthraquinones were potently cytotoxic (nM IC50s) against c

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