Relevant bibliographies by topics / Anti α-glucosidase

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  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Anti α-glucosidase'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Anti α-glucosidase"

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Chen, Wei-Cheng, Shih-Wei Wang, Cai-Wei Li та ін. "Comparison of Various Solvent Extracts and Major Bioactive Components from Portulaca oleracea for Antioxidant, Anti-Tyrosinase, and Anti-α-Glucosidase Activities". Antioxidants 11, № 2 (2022): 398. http://dx.doi.org/10.3390/antiox11020398.

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Portulaca oleracea is a well-known species for traditional medicine and food homology in Taiwan. In traditional medicine, P. oleracea is also used to treat gastrointestinal disorders, liver inflammation, fever, severe inflammation, and headaches. We investigated antioxidant, anti-tyrosinase, and anti-α-glucosidase activities of various solvent extracts and major bioactive components from P. oleracea. Ethanol and acetone extracts showed potent DPPH, ABTS, and hydroxyl radical scavenging activities. Chloroform and n-hexane extracts displayed significant superoxide radical scavenging activity. Fu
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Widowati, Wahyu, Maesaroh Maesaroh, Nurul Fauziah, Pande Putu Erawijantari, and Ferry Sandra. "Free Radical Scavenging and Alpha/Beta-glucosidases Inhibitory Activities of Rambutan (Nephelium lappaceum L.) Peel Extract." Indonesian Biomedical Journal 7, no. 3 (2015): 157. http://dx.doi.org/10.18585/inabj.v7i3.180.

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BACKGROUND: Diabetes mellitus (DM) is associated with oxidative reaction and hyperglycemic condition. Human body has an antioxidant defense system toward free radical, but overproduction of free radical causing imbalance condition between the free radical and the antioxidant defense in the body that lead to several diseases, including DM. Glucosidase is an enzyme that hydrolize carbohydrates causing increase of blood glucose level, so by inhibiting this enzyme blood glucose level in plasma could be effectively decreased. Rambutan (Nephelium lappaceum L.) peel has been reported to have many pot
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Tsai, Chia-Hsuan, Ya-Lun Liou, Sin-Min Li, Hsiang-Ruei Liao та Jih-Jung Chen. "Antioxidant, Anti-α-Glucosidase, Anti-Tyrosinase, and Anti-Acetylcholinesterase Components from Stem of Rhamnus formosana with Molecular Docking Study". Antioxidants 14, № 1 (2024): 8. https://doi.org/10.3390/antiox14010008.

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Rhamnus formosana is a creeping evergreen shrub endemic to Taiwan. In traditional medicine, Rhamnaceae plants are used as herbal remedies for conditions such as itching, difficulty urinating, and constipation. This study explores the inhibitory effects of various solvent extracts and bioactive components of R. formosana on α-glucosidase, tyrosinase, acetylcholinesterase (AChE), and antioxidant activity. The 100 °C water extract exhibited strong antioxidant activity in DPPH, ABTS, superoxide, and FRAP assays. The methanol extract demonstrated the highest α-glucosidase inhibitory effect, while t
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Li, Mengyue, Lin Li, Li Lu, Xuetao Xu, Jinhui Hu та Jin-Bao Peng. "Anti-α-Glucosidase, SAR Analysis, and Mechanism Investigation of Indolo[1,2-b]isoquinoline Derivatives". Molecules 28, № 13 (2023): 5282. http://dx.doi.org/10.3390/molecules28135282.

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To find potential α-glucosidase inhibitors, indolo[1,2-b]isoquinoline derivatives (1–20) were screened for their α-glucosidase inhibitory effects. All derivatives presented potential α-glucosidase inhibitory effects with IC50 values of 3.44 ± 0.36~41.24 ± 0.26 μM compared to the positive control acarbose (IC50 value: 640.57 ± 5.13 μM). In particular, compound 11 displayed the strongest anti-α-glucosidase activity, being ~186 times stronger than acarbose. Kinetic studies found that compounds 9, 11, 13, 18, and 19 were all reversible mix-type inhibitors. The 3D fluorescence spectra and CD spectr
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Ryu, BoMi, Yunfei Jiang, Hyun-Soo Kim та ін. "Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-α-Glucosidase Activity of Ishige okamurae". Marine Drugs 16, № 11 (2018): 436. http://dx.doi.org/10.3390/md16110436.

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Nutraceutical use of algae requires understanding of the diversity and significance of their active compositions for intended activities. Ishige okamurae (I. okamurae) extract is well-known to possess α-glucosidase inhibitory activity; however, studies are needed to investigate its active composition in order to standardize its α-glucosidase inhibitory activity. In this study, we observed the intensity of the dominant compounds of each I. okamurae extract harvested between 2016 and 2017, and the different potency of each I. okamurae extract against α-glucosidase. By comparing the anti-α-glucos
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Singh, Parvesh, Nomandla Ngcoya, Ramgopal Mopuri та ін. "α-Glucosidase Inhibition, Antioxidant and Docking Studies of Hydroxycoumarins and their Mono and Bis O-alkylated/acetylated Analogs". Letters in Drug Design & Discovery 15, № 2 (2018): 127–35. http://dx.doi.org/10.2174/1570180814666170602081941.

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Background: Diabetes Mellitus (DM) is a complex metabolic disease illustrated by abnormally high levels of plasma glucose or hyperglycaemia. Accordingly, several α-glucosidase inhibitors have been developed for the treatment of diabetes and other degenerative disorders. While, a coumarin ring has the privilege to represent numerous natural and synthetic compounds with a wide spectrum of biological activities e.g. anti-cancer, anti-HIV, anti-viral, anti-malarial, anti-microbial, anti-convulsant, anti-hypertensive properties. Besides this, coumarins have also shown potential to inhibit α-glucosi
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Khan, Yousaf, Shoaib Khan, Rafaqat Hussain та ін. "The Synthesis, In Vitro Bio-Evaluation, and In Silico Molecular Docking Studies of Pyrazoline–Thiazole Hybrid Analogues as Promising Anti-α-Glucosidase and Anti-Urease Agents". Pharmaceuticals 16, № 12 (2023): 1650. http://dx.doi.org/10.3390/ph16121650.

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In the present work, a concise library of benzothiazole-derived pyrazoline-based thiazole (1–17) was designed and synthesized by employing a multistep reaction strategy. The newly synthesized compounds were screened for their α-glucosidase and urease inhibitory activities. The scaffolds (1–17) were characterized using a combination of several spectroscopic techniques, including FT-IR, 1H-NMR, 13C-NMR, and EI-MS. The majority of the synthesized compounds demonstrated a notable potency against α-glucosidase and urease enzymes. These analogues disclosed varying degrees of α-glucosidase and urease
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AlKhaldi, Kholowd, Manal Daghestani, and Thanaa Al-Haddad. "In vitro anti-diabetic activity of Tribulus terrestrisL. fruits extracts." Nutrition & Food Science 50, no. 4 (2019): 631–40. http://dx.doi.org/10.1108/nfs-06-2019-0180.

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Purpose The purpose of this paper is to evaluate the inhibition activity of Tribulus terrestris L. (T. terrestris) fruits extracts with solvents of increasing polarity against α-glucosidase and α-amylase, and to determine the inhibition mode of the most effective extract against both enzymes. Design/methodology/approach Hexane, acetone, ethanol and aqueous extracts of T. terrestris fruits were prepared using ultrasonic sequential extraction and analyzed for their α-amylase and α-glucosidase inhibitory activities by specific assay for each enzyme. The modes of inhibitions were detected using Li
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Yuan, Hao, Hong Wan, Yi-Kao Hu та ін. "Fishing of α-Glucosidase’s Ligands from Aloe vera by α-Glucosidase Functionalized Magnetic Nanoparticles". Molecules 26, № 19 (2021): 5840. http://dx.doi.org/10.3390/molecules26195840.

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α-Glucosidase was immobilized on magnetic nanoparticles (MNPs) for selective solid-phase extraction of the enzyme’s ligands present in Aloe vera, which is a medicinal plant used for the treatment of various diseases and possesses anti-diabetic activity. One new compound, aloeacone (2), together with two known compounds, aloenin aglycone (1) and aloin A (3), were fished out as the enzyme’s ligands. The structure of 2 was determined by HR-MS and comprehensive NMR techniques. Compound 3 exhibited a weak inhibitory effect on α-glucosidase, while compounds 1 and 2 were found to possess activation e
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Bui, Tung Thanh, Khanh Phuong Thi Nguyen, Phung Phi Kim Nguyen, Dung Tien Le та Thuy Le Thi Nguyen. "Anti-Inflammatory and α-Glucosidase Inhibitory Activities of Chemical Constituents from Bruguiera parviflora Leaves". Journal of Chemistry 2022 (11 квітня 2022): 1–9. http://dx.doi.org/10.1155/2022/3049994.

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Bruguiera parviflora (Rhizophoraceae) is one of the Bruguiera genus-based mangrove plants which has not been investigated for the chemical compositions as well as biological activities so far. The present study was aimed at investigating the phytochemicals as well as anti-inflammatory and α-glucosidase inhibitory activities of B. parviflora leaves. The results showed that the crude extract and its fractions significantly increased the percentage inhibitory activity against α-glucosidase and decreased NO production in LPS-stimulated RAW 264.7 cells in a dose-dependent manner. The most effective
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Dissertations / Theses on the topic "Anti α-glucosidase"

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Ryan, Caroline Mary. "Anti-Diabetic and Anti-Obesity Activities of Cocoa (Theobroma cacao) via Physiological Enzyme Inhibition." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/75003.

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Fermentation and roasting of cocoa (Theobroma cacao) decrease levels of polyphenolic flavanol compounds. However, it is largely unknown how these changes in polyphenol levels caused by processing affect cocoa's anti-diabetic and anti-obesity bioactivities, such as inhibition of certain enzymes in the body. Polyphenol profiles, protein-binding abilities, presence of compounds termed oxidative polymers, and abilities to inhibit α-glucosidase, pancreatic α-amylase, lipase, and dipeptidyl peptidase-IV (DPP4) in vitro were compared between unfermented bean (UB), fermented bean (FB), unfermented liq
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Matrose, Albertina Neliswa. "Evaluation of the antioxidant and anti-diabesity potential of cyclopia maculata using in vitro non-cell based screening models." Thesis, University of the Western Cape, 2014. http://hdl.handle.net/11394/4262.

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Masters of Science<br>The aim of this study was therefore to evaluate the antioxidant and anti-diabesity potential of a hot water extract of C. maculata in non-cell based assays and correlate the activities with phenolic composition. Total antioxidant capacity (TAC) was assessed in terms of free radical scavenging and iron reducing ability. The DPPH, ABTS, ORAC and FRAP assays were employed. Anti-diabesity potential was assessed in terms of the inhibition of the digestive enzymes, α-glucosidase and pancreatic lipase
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Lin, Jia-Wen, та 林佳雯. "Anti-hyperglycemia activity of Galla chinensis based on the inhibition of α- glucosidase activity". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/46143593918166268087.

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碩士<br>臺灣大學<br>食品科技研究所<br>98<br>Diabetes mellitus (DM) is a common metabolism disease worldwide. DM is also on the top five list of the ten major causes of death in Taiwan for many years. Hyperglycemia is the main symptom to the DM patients. It obten inducesvarious complications, and postprandial hyperglycemia is the principal factor of DM complications. Among many kinds of diabetic medicines, only α-glucosidase inhibitors can significantly lower postprandial blood glucose. This research used α-glucosidase inhibition assay to find the plant materials which has ability to inhibit α-glucosidase.
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Mao, Ying-Chun, та 毛瀅鈞. "Studies on α-Amylase and α-Glucosidase Inhibition and Anti-glycation Activities by Guava (Psidium guajava L.) Leaf Extracts". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/04093490044014034269.

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碩士<br>國立嘉義大學<br>食品科學系研究所<br>101<br>In this study, guava (Psidium guajava L.) leaves were employed as the raw material, and were extracted by hot water and 4% hot acetic acid. The polyphenolic contents and antioxidant capability in the extract were determined and inhibitive activity of α-amylase, α-glucosidase and glycation were also evaluated. The results showed that the extract (4% acetic acid heated for 60 minutes at 90℃) was able to obtain the highest potency of totoal polyphenolic contents (3.04 mg/mL), condensed tannins (1.72 mg/mL) and total flavonoids (2.08 mg/mL) in the different resul
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Da, Costa Mousinho Nuno Miguel Holmes. "In vitro assessment of the anti-diabetic activity of Sclerocarya birrea and Ziziphus mucronata." Diss., 2013. http://hdl.handle.net/2263/33337.

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Diabetes mellitus is a growing threat to human health. Current pharmacological agents cause undesirable side-effects. Herbal remedies offer the potential for alternative treatment strategies that may prove more cost-effective and devoid of the undesirable side-effects. The purpose of this study was to evaluate the in vitro anti-diabetic activity of aqueous and methanol extracts of Sclerocarya birrea (A. Rich.) Hochst. (Anacardiaceae) and Ziziphus mucronata Willd. (Rhamnaceae), which are traditionally used for the treatment of diabetes mellitus in southern Africa. Polyphenolic contents of extr
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Book chapters on the topic "Anti α-glucosidase"

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Zhou, Kequan, Shelly Hogan, Corene Canning, and Shi Sun. "Inhibition of Intestinal α-Glucosidases and Anti-Postprandial Hyperglycemic Effect of Grape Seed Extract." In ACS Symposium Series. American Chemical Society, 2012. http://dx.doi.org/10.1021/bk-2012-1093.ch025.

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"Iminosugar α-Glucosidase Inhibitors." In Anti-AIDS Drug Development. CRC Press, 1995. http://dx.doi.org/10.1201/9781482287226-9.

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Sansi, Manish Singh, Daraksha Iram, Kapil Singh Narayan, Sandeep Kumar, Om Prakash, and Dipanjan Misra. "Antidiabetic Activity (Anti-Hyperglycemic Activity, Anti-Hyperlipidemic Activity)/Agents From Medicinal Plants." In Advanced Pharmacological Uses of Medicinal Plants and Natural Products. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-2094-9.ch002.

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Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased insulin secretion by the organ. Insulin deficiency causes the DM. Synthetic drugs are widely used in the treatment of diabetes, but they have some side effects. The antihyperglycemic and antihyperlipedemic effects of the plants are related to their ability to maintain pancreatic function. Medicinal plants constituents such as glycosides, alkaloids, terpenoids, and flavonoids mitigate DM. B. ciliata inhibits the α-glucosidase and α-amylase. Cinnamon extracts improve insul
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Sansi, Manish Singh, Daraksha Iram, Kapil Singh Narayan, Sandeep Kumar, Om Prakash, and Dipanjan Misra. "Antidiabetic Activity (Anti-Hyperglycemic Activity, Anti-Hyperlipidemic Activity)/Agents From Medicinal Plants." In Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-3546-5.ch014.

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Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased insulin secretion by the organ. Insulin deficiency causes the DM. Synthetic drugs are widely used in the treatment of diabetes, but they have some side effects. The antihyperglycemic and antihyperlipedemic effects of the plants are related to their ability to maintain pancreatic function. Medicinal plants constituents such as glycosides, alkaloids, terpenoids, and flavonoids mitigate DM. B. ciliata inhibits the α-glucosidase and α-amylase. Cinnamon extracts improve insul
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Resool Hussein, Malik Yahia Abdul, Narender Malothu, and Haritha Lanka. "Phytochemical Study, in Vitro Antioxidant and Antidiabetic Activity of Methonalic Leaf Extract of Linderina Parviflora." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00656.

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In a general context, the significance of a number of medicinal plants has been investigated in the treatment of diabetes mellitus. In this regard, to establish the anti-diabetic potential of Linderina Parviflora, one of the medicinal herbs this study was initiated. The main objective of the study was to evaluate the in vitro anti-oxidant and anti-diabetic activity of methanolic extracts of Linderina Parviflora leaves. During screening for phytochemicals the total phenolic and flavonoid content was estimated. In vitro antidiabetic activity was assessed by α-glucosidase and α-amylase inhibitory
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Yakin, Mr Josef, Mr Arghya Saha Choudhury, Dr Faruk Alam, and Mr Mohidul Islam. "Marine Resources: Management of Diabetes." In Pharmaceutical Science: Research and Innovation. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/psrich17.

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Diabetes mellitus, a chronic condition that may be life-threatening is a huge threat to the health of people all over the world. Conventional treatments provide only a limited number of remedies, and they often come with unintended consequences. An exceptional opportunity for the development of new anti-diabetic medicines that have strong actions and reduced side effects is presented by the huge marine environment, which has not been investigated to its full potential. Subsequent metabolites derived from marine creatures are the subject of this review, which dives into the fascinating world of
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V, N. V. L. Suvarchala Reddy, Ganga Raju M, Konaparthi Sree Bhavya, Korra Anasuya, Polagoni Shrivani, and Polisetty Amrutha. "IN VITRO ANTI-INFLAMMATORY AND ANTIDIABETIC ACTIVITY OF HIBISCUS ROSA SINENSIS." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 18. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn18p5ch1.

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Natural plant products are growing in popularity nowadays as a result of increase in the number of illnesses. The Malvaceae family includes the plant Hibiscus rosa sinensis Linn, which may exist everywhere in the globe. Its leaves, bark, roots, and flowers have been employed to treat a number of ailments in traditional Indian medicine. Hibiscus rosa sinensis, commonly known as the Chinese hibiscus, a plant whose traditional medical uses date back a long time. This research sought to determine if an extract of Hibiscus rosa sinensis (Red tea) would have any in vitro anti-inflammatory and anti-d
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Gunathilaka, Thilina, Lakshika Rangee Keertihirathna, and Dinithi Peiris. "Advanced Pharmacological Uses of Marine Algae as an Anti-Diabetic Therapy." In Pharmacognosy - Medicinal Plants [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96807.

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Marine seaweeds are a promising source of bioactive secondary metabolites that can be utilized in drug development and nutraceuticals. Diabetes mellitus is a leading non-communicable disease, and it is the third leading cause of death worldwide. Among the types of diabetes, type 2 became the major health problem as it is associated with severe health complications. Since available oral hypoglycemic drugs cause several adverse effects, it is worth searching for a natural cure with fewer or no side effects that may benefit patients with type 2 diabetes. Among the marine seaweeds, brown and red s
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McGrowder, Donovan Anthony, Fabian G. Miller, Chukwuemeka Nwokocha, et al. "Medical Herbs and the Treatment of Diabetes Mellitus." In Treating Endocrine and Metabolic Disorders With Herbal Medicines. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4808-0.ch003.

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Diabetes mellitus is a chronic metabolic disorder that affects millions of persons worldwide, and if uncontrolled may cause cardiovascular disease, retinopathy, or chronic kidney disease. Effective therapeutic management of diabetes mellitus involves the use of mainly oral hypoglycemic drugs whose mechanism of action includes improved insulin secretion, reduced insulin resistance, or increased glucose uptake. There is growing exploration of medicinal herbs as potential therapeutic sources for the management of type 2 diabetes mellitus and compared with conventional oral hypoglycemic drugs they
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Yakin, Mr Josef, Mr Abdul Hadi Umam, Mr Kangkan Jyoti Saud, and Dr Faruk Alam. "Glycosides: An Effect in the Treatment of Diabetes Mellitus." In Pharmaceutical Science: Research and Innovation. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/psrich12.

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Diabetes is a medical condition that is among the leading causes of mortality in both industrialised and developing nations. For the treatment of diabetes, a great number of synthetic medicines are now being used. However, these medications have a wide range of negative side effects. In light of this, there is an urgent need for the development of novel medicines that have the potential to be helpful in improve diabetes control. Since the beginning of time, herbal medicines have been widely acknowledged for their medicinal potential in treating a variety of diseases and illnesses. Natural reme
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Conference papers on the topic "Anti α-glucosidase"

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ELObeid, Tahra, Susanna Phoboo, and Kalidas Shetty. "Anti-diabetic and Anti-hypertensive Potential of Indigenous Edible plants of Qatar." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0142.

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Aizoon Canariense, Cynomorium Coccineum, Glossonema Edule, and Malva Parviflora, edible desert plants from Qatar, were selected to determine levels of phenolic bioactives and potential health benefits for managing early stages of type 2 diabetes and hypertension. Aqueous extracts of C. Cocineum, contained soluble phenolics and had relatively high levels of antioxidant activity associated with α-glucosidase, α-amylase, and angiotensin- converting enzyme (ACE). G. Edule and M. Parviflora had moderate levels of anti-oxidant potential, soluble phenolics, and ACE inhibitory activity. The medicinal
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Zhao, Y., K. Kongstad, AK Jäger та D. Staerk. "Triple high-resolution α-glucosidase/α-amylase/PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-diabetic constituents from Morus alba L." У GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608334.

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