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Journal articles on the topic 'Anti α-glucosidase'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Chen, Wei-Cheng, Shih-Wei Wang, Cai-Wei Li та ін. "Comparison of Various Solvent Extracts and Major Bioactive Components from Portulaca oleracea for Antioxidant, Anti-Tyrosinase, and Anti-α-Glucosidase Activities". Antioxidants 11, № 2 (2022): 398. http://dx.doi.org/10.3390/antiox11020398.

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Portulaca oleracea is a well-known species for traditional medicine and food homology in Taiwan. In traditional medicine, P. oleracea is also used to treat gastrointestinal disorders, liver inflammation, fever, severe inflammation, and headaches. We investigated antioxidant, anti-tyrosinase, and anti-α-glucosidase activities of various solvent extracts and major bioactive components from P. oleracea. Ethanol and acetone extracts showed potent DPPH, ABTS, and hydroxyl radical scavenging activities. Chloroform and n-hexane extracts displayed significant superoxide radical scavenging activity. Fu

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2

Widowati, Wahyu, Maesaroh Maesaroh, Nurul Fauziah, Pande Putu Erawijantari, and Ferry Sandra. "Free Radical Scavenging and Alpha/Beta-glucosidases Inhibitory Activities of Rambutan (Nephelium lappaceum L.) Peel Extract." Indonesian Biomedical Journal 7, no. 3 (2015): 157. http://dx.doi.org/10.18585/inabj.v7i3.180.

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BACKGROUND: Diabetes mellitus (DM) is associated with oxidative reaction and hyperglycemic condition. Human body has an antioxidant defense system toward free radical, but overproduction of free radical causing imbalance condition between the free radical and the antioxidant defense in the body that lead to several diseases, including DM. Glucosidase is an enzyme that hydrolize carbohydrates causing increase of blood glucose level, so by inhibiting this enzyme blood glucose level in plasma could be effectively decreased. Rambutan (Nephelium lappaceum L.) peel has been reported to have many pot

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3

Tsai, Chia-Hsuan, Ya-Lun Liou, Sin-Min Li, Hsiang-Ruei Liao та Jih-Jung Chen. "Antioxidant, Anti-α-Glucosidase, Anti-Tyrosinase, and Anti-Acetylcholinesterase Components from Stem of Rhamnus formosana with Molecular Docking Study". Antioxidants 14, № 1 (2024): 8. https://doi.org/10.3390/antiox14010008.

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Rhamnus formosana is a creeping evergreen shrub endemic to Taiwan. In traditional medicine, Rhamnaceae plants are used as herbal remedies for conditions such as itching, difficulty urinating, and constipation. This study explores the inhibitory effects of various solvent extracts and bioactive components of R. formosana on α-glucosidase, tyrosinase, acetylcholinesterase (AChE), and antioxidant activity. The 100 °C water extract exhibited strong antioxidant activity in DPPH, ABTS, superoxide, and FRAP assays. The methanol extract demonstrated the highest α-glucosidase inhibitory effect, while t

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4

Li, Mengyue, Lin Li, Li Lu, Xuetao Xu, Jinhui Hu та Jin-Bao Peng. "Anti-α-Glucosidase, SAR Analysis, and Mechanism Investigation of Indolo[1,2-b]isoquinoline Derivatives". Molecules 28, № 13 (2023): 5282. http://dx.doi.org/10.3390/molecules28135282.

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To find potential α-glucosidase inhibitors, indolo[1,2-b]isoquinoline derivatives (1–20) were screened for their α-glucosidase inhibitory effects. All derivatives presented potential α-glucosidase inhibitory effects with IC50 values of 3.44 ± 0.36~41.24 ± 0.26 μM compared to the positive control acarbose (IC50 value: 640.57 ± 5.13 μM). In particular, compound 11 displayed the strongest anti-α-glucosidase activity, being ~186 times stronger than acarbose. Kinetic studies found that compounds 9, 11, 13, 18, and 19 were all reversible mix-type inhibitors. The 3D fluorescence spectra and CD spectr

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5

Ryu, BoMi, Yunfei Jiang, Hyun-Soo Kim та ін. "Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-α-Glucosidase Activity of Ishige okamurae". Marine Drugs 16, № 11 (2018): 436. http://dx.doi.org/10.3390/md16110436.

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Nutraceutical use of algae requires understanding of the diversity and significance of their active compositions for intended activities. Ishige okamurae (I. okamurae) extract is well-known to possess α-glucosidase inhibitory activity; however, studies are needed to investigate its active composition in order to standardize its α-glucosidase inhibitory activity. In this study, we observed the intensity of the dominant compounds of each I. okamurae extract harvested between 2016 and 2017, and the different potency of each I. okamurae extract against α-glucosidase. By comparing the anti-α-glucos

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Singh, Parvesh, Nomandla Ngcoya, Ramgopal Mopuri та ін. "α-Glucosidase Inhibition, Antioxidant and Docking Studies of Hydroxycoumarins and their Mono and Bis O-alkylated/acetylated Analogs". Letters in Drug Design & Discovery 15, № 2 (2018): 127–35. http://dx.doi.org/10.2174/1570180814666170602081941.

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Background: Diabetes Mellitus (DM) is a complex metabolic disease illustrated by abnormally high levels of plasma glucose or hyperglycaemia. Accordingly, several α-glucosidase inhibitors have been developed for the treatment of diabetes and other degenerative disorders. While, a coumarin ring has the privilege to represent numerous natural and synthetic compounds with a wide spectrum of biological activities e.g. anti-cancer, anti-HIV, anti-viral, anti-malarial, anti-microbial, anti-convulsant, anti-hypertensive properties. Besides this, coumarins have also shown potential to inhibit α-glucosi

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7

Khan, Yousaf, Shoaib Khan, Rafaqat Hussain та ін. "The Synthesis, In Vitro Bio-Evaluation, and In Silico Molecular Docking Studies of Pyrazoline–Thiazole Hybrid Analogues as Promising Anti-α-Glucosidase and Anti-Urease Agents". Pharmaceuticals 16, № 12 (2023): 1650. http://dx.doi.org/10.3390/ph16121650.

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In the present work, a concise library of benzothiazole-derived pyrazoline-based thiazole (1–17) was designed and synthesized by employing a multistep reaction strategy. The newly synthesized compounds were screened for their α-glucosidase and urease inhibitory activities. The scaffolds (1–17) were characterized using a combination of several spectroscopic techniques, including FT-IR, 1H-NMR, 13C-NMR, and EI-MS. The majority of the synthesized compounds demonstrated a notable potency against α-glucosidase and urease enzymes. These analogues disclosed varying degrees of α-glucosidase and urease

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8

AlKhaldi, Kholowd, Manal Daghestani, and Thanaa Al-Haddad. "In vitro anti-diabetic activity of Tribulus terrestrisL. fruits extracts." Nutrition & Food Science 50, no. 4 (2019): 631–40. http://dx.doi.org/10.1108/nfs-06-2019-0180.

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Purpose The purpose of this paper is to evaluate the inhibition activity of Tribulus terrestris L. (T. terrestris) fruits extracts with solvents of increasing polarity against α-glucosidase and α-amylase, and to determine the inhibition mode of the most effective extract against both enzymes. Design/methodology/approach Hexane, acetone, ethanol and aqueous extracts of T. terrestris fruits were prepared using ultrasonic sequential extraction and analyzed for their α-amylase and α-glucosidase inhibitory activities by specific assay for each enzyme. The modes of inhibitions were detected using Li

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9

Yuan, Hao, Hong Wan, Yi-Kao Hu та ін. "Fishing of α-Glucosidase’s Ligands from Aloe vera by α-Glucosidase Functionalized Magnetic Nanoparticles". Molecules 26, № 19 (2021): 5840. http://dx.doi.org/10.3390/molecules26195840.

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α-Glucosidase was immobilized on magnetic nanoparticles (MNPs) for selective solid-phase extraction of the enzyme’s ligands present in Aloe vera, which is a medicinal plant used for the treatment of various diseases and possesses anti-diabetic activity. One new compound, aloeacone (2), together with two known compounds, aloenin aglycone (1) and aloin A (3), were fished out as the enzyme’s ligands. The structure of 2 was determined by HR-MS and comprehensive NMR techniques. Compound 3 exhibited a weak inhibitory effect on α-glucosidase, while compounds 1 and 2 were found to possess activation e

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10

Bui, Tung Thanh, Khanh Phuong Thi Nguyen, Phung Phi Kim Nguyen, Dung Tien Le та Thuy Le Thi Nguyen. "Anti-Inflammatory and α-Glucosidase Inhibitory Activities of Chemical Constituents from Bruguiera parviflora Leaves". Journal of Chemistry 2022 (11 квітня 2022): 1–9. http://dx.doi.org/10.1155/2022/3049994.

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Bruguiera parviflora (Rhizophoraceae) is one of the Bruguiera genus-based mangrove plants which has not been investigated for the chemical compositions as well as biological activities so far. The present study was aimed at investigating the phytochemicals as well as anti-inflammatory and α-glucosidase inhibitory activities of B. parviflora leaves. The results showed that the crude extract and its fractions significantly increased the percentage inhibitory activity against α-glucosidase and decreased NO production in LPS-stimulated RAW 264.7 cells in a dose-dependent manner. The most effective

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11

Lin, Yen-Ting, Hsiang-Ru Lin, Chang-Syun Yang та ін. "Antioxidant and Anti-α-Glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Fruits of Crataegus pinnatifida". Antioxidants 11, № 2 (2022): 320. http://dx.doi.org/10.3390/antiox11020320.

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Crataegus pinnatifida is used to treat various diseases, including indigestion, congestive heart failure, hypertension, atherosclerosis, and myocardial dysfunction. We evaluated antioxidant and anti-α-glucosidase activities of various solvent extracts and major bioactive components from the fruit of C. pinnatifida. Ethyl acetate extracts showed potent antioxidant activities with IC50 values of 23.26 ± 1.97 and 50.73 ± 8.03 μg/mL, respectively, in DPPH and ABTS radical scavenging assays. Acetone extract exhibited significant anti-α-glucosidase activity with IC50 values of 42.35 ± 2.48 μg/mL. HP

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12

Sinha, Durgeshnandani, Trilochan Satapathy, Parag Jain, et al. "In Vitro Antidiabetic Effect of Neohesperidin." Journal of Drug Delivery and Therapeutics 9, no. 6 (2019): 102–9. http://dx.doi.org/10.22270/jddt.v9i6.3633.

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Objective: The present study was performed to determine in vitro antidiabetic effect of neohesperidin. To evaluate inhibitory effect of neohesperidin on α-amylase and α-glucosidase diabetes causing enzyme. Methods and Materials: Invitro carbohydrate metabolizing enzyme based inhibitory methods were used to determine antidiabetic effect of neohesperidin. Alpha (α)-amylase inhibitory assay was performed using different sources i.e. wheat alpha (α)-amylase enzyme, salivary alpha (α)-amylase and fungal alpha (α)-amylase assay. Alpha (α)-glucosidase inhibitory assay was performed using alpha

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13

Arjita, I. P. D., I. W. P. S. Yasa, N. N. A. Dewi та ін. "Potential α-glucosidase inhibitor in nyale worm (Eunice sp.) extract for anti-diabetic type 2 target". Regulatory Mechanisms in Biosystems 15, № 4 (2024): 900–906. https://doi.org/10.15421/0224130.

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Nyale (Annelida, Eunicida, Eunicidae) is a typical sea worm of Kuta-Mandalika beach, Central Lombok, Indonesia. Diabetes mellitus is a chronic disease characterized by high blood sugar levels (glucose). Diabetes occurs because the body cannot produce enough insulin or cannot use insulin effectively. The α-glucosidase enzyme is a potential target in managing diabetes mellitus, particularly type 2 diabetes. This enzyme plays a role in the breakdown of complex carbohydrates into simple sugars in the small intestine. These sugars are then absorbed into the bloodstream and then blood sugar levels a

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14

Banerjee, Anindita, Bithin Maji, Sandip Mukherjee, Kausik Chaudhuri, and Tapan Seal. "IN VITRO ANTI-DIABETIC AND ANTI-OXIDANT ACTIVITIES OF ETHANOL EXTRACT OF TINOSPORA SINENSIS." International Journal of Current Pharmaceutical Research 9, no. 2 (2017): 42. http://dx.doi.org/10.22159/ijcpr.2017v9i2.17379.

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Objective: The aim of the present study was to evaluate the alpha (α)-amylase and alpha (α)-glucosidase inhibitory activities and in vitro antioxidant activities of the 80 % aqueous ethanol extracts of Tinosporasinensis Lour (Merr.).Methods: The 80% aq. ethanol extract of the plant was prepared. The plant extract was examined for its antioxidant activity by using free radical 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging method, ABTS radical scavenging ability, reducing power capacity, estimation of total phenolic content, flavonoid content and flavonol content. Different concentrations (2,

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15

Dhanya, B. P., Greeshma Gopalan, T. R. Reshmitha, et al. "Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities." New Journal of Chemistry 41, no. 15 (2017): 6960–64. http://dx.doi.org/10.1039/c7nj01098b.

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16

Dalu, Damayanthi, and Satyavati Dhulipala. "Evaluation of possible mechanisms of three plants for blood glucose control in diabetes." Bangladesh Journal of Pharmacology 11, no. 1 (2016): 224. http://dx.doi.org/10.3329/bjp.v11i1.24932.

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<p class="Abstract">This study was conducted to provide the evidence for the mechanism of anti-diabetic activity of <em>Cocculus orbiculatus, Leea indica</em> and <em>Ventilago maderaspatana</em>. This was accomplished by employing methods like uptake of glucose, glycogen synthesis and inhibition of α-glucosidase. For uptake of glucose, diaphragms were dissected out in Tyrode solution with 2% glucose and assayed for glucose content. In glycogen synthesis methodology liver, skeletal muscle and cardiac muscles were isolated, homogenized and glycogen content was anal

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17

S, Shalini, Rakshana N, and Menaka R. "Evaluation of Alpha-amylase and Alpha-glucosidase Activities of Brahmi Nei: An In-vitro Study." Journal of Advances in Medical and Pharmaceutical Sciences 27, no. 3 (2025): 46–53. https://doi.org/10.9734/jamps/2025/v27i3757.

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α-amylase and α-glucosidase enzymes break down carbohydrates, leading to spikes in postprandial glucose levels in diabetic patients. Suppression of these enzyme activities helps regulate blood glucose levels and lower the risk of diabetes complications. Brahmi together with Ghee helps to regulate postprandial hyperglycaemia in diabetic patients. In this study, Brahmi Nei (BN) evaluated their ability to inhibit α-amylase and α-glucosidase activities in-vitro. The ability of BN to inhibit α-amylase and α-glucosidase activities was measured by the Spectrophotometric method, which involves measuri

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18

Ginaris, Rifkarosita Putri, та Naimatul Retno Fauzah. "The Effectiveness of Flavonoids in Pigeon Pea (Cajanus cajan) as Inhibitors of α-Glucosidase Enzyme in Anti-diabetes". FITOFARMAKA: JURNAL ILMIAH FARMASI 13, № 2 (2023): 139–45. http://dx.doi.org/10.33751/jf.v13i2.9311.

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Diabetes mellitus is a metabolic disease characterized by hyperglycemia, due to relative and absolute insulin deficiency of the body. Acarbose is a drug that can be used to treat diabetes mellitus, especially type II diabetes mellitus. Type II diabetes mellitus is an endocrine disease that causes 95 % of deaths worldwide. Gude bean extract (Cajanus cajan) is one alternative to the use of natural anti-diabetic medicine, containing saponins, flavonoids, phenolics, and tannins. Flavonoids are antioxidant compounds that have a hypoglycemia effect in people with diabetes mellitus. This study aimed

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Mujawah, Adil, Abdur Rauf, Sami Bawazeer, Abdul Wadood, Hassan A. Hemeg та Saud Bawazeer. "Isolation, Structural Elucidation, In Vitro Anti-α-Glucosidase, Anti-β-Secretase, and In Silico Studies of Bioactive Compound Isolated from Syzygium cumini L." Processes 11, № 3 (2023): 880. http://dx.doi.org/10.3390/pr11030880.

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Diabetes is one of the main health issues worldwide because of its lifetime duration. To overcome this health problem, the current study was conducted. This investigation aims to explore the α-glucosidase and β-secretase potential of extract/fractions and pure isolated compounds of Syzygium cumini bark. The chloroform extract of Syzygium cumini bark was subjected to chromatographic analysis to yield compound 1. The structure of isolated phytochemical (1) was conducted using advanced spectroscopic analysis. Among test extracts, the chloroform fraction exhibited a significant effect against α-gl

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20

Tran, Linh Thuy Thi, Khanh Tan Nguyen, Ty Viet Pham та ін. "Chemical Composition, Anti-α-Glucosidase Activity, and Molecular Modelling Studies of Cleistocalyx operculatus Essential Oil". Applied Sciences 13, № 20 (2023): 11224. http://dx.doi.org/10.3390/app132011224.

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In this study, chemical components, α-glucosidase inhibitory activities, and molecular modelling studies of the essential oil extracted from the Cleistocalyx operculatus leaves were investigated. In total, thirty compounds were identified using GC/MS, representing 98.3% of the oil. Of these, the two most dominant constituents of the essential oil were determined as (Z)-β-ocimene (30.4%) and allo-ocimene (31.6%). The α-glucosidase inhibitory experiments indicated that the essential oil exhibited potent α-glucosidase inhibitory activities, with IC50 values of 61.82 ± 3.91 µg/mL. For further inve

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Ibrahim, Mohammed Auwal, James Dama Habila, Neil Anthony Koorbanally та Md Shahidul Islam. "α-Glucosidase and α-Amylase Inhibitory Compounds from three African Medicinal Plants: An Enzyme Inhibition Kinetics Approach". Natural Product Communications 12, № 7 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200731.

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The quest to find new lead compounds with anti-diabetic effects via the inhibition of α-glucosidase and α-amylase had led us to conduct bioassay guided isolation of three African medicinal plants which resulted in the identification of bicyclo[2.2.0]hexane-2,3,5-triol (1), 3β- O-acetyl betulinic acid (2) and 2,7-dihydroxy-4 H-1-benzopyran-4-one (3), as the bioactive compounds. The compounds demonstrated a significant (P < 0.05) inhibitory effect on α-glucosidase and α-amylase activities than acarbose. Steady state kinetic analysis revealed that compounds 1 and 2 inhibited both α-amylase and

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22

Wang, Huafu, Huang Gang, Shuxin Zhou та ін. "Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase". médecine/sciences 34 (жовтень 2018): 4–7. http://dx.doi.org/10.1051/medsci/201834f101.

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Objective: Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time in China. Methods: In this study, the water extract of LWDH was tested for its α-Amylase and α-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed. Results: LWDH extract inhibited α-Glucosidase and α-Amylase activities in a dose- dependent manner. Treatment of streptozotocin-induced diabetic mice w

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23

Wang, Jiangming, Silei Lu, Ruilong Sheng, Junting Fan, Wenhui Wu та Ruihua Guo. "Structure-Activity Relationships of Natural and Synthetic Indole-Derived Scaffolds as α-Glucosidase Inhibitors: A Mini-Review". Mini-Reviews in Medicinal Chemistry 20, № 17 (2020): 1791–818. http://dx.doi.org/10.2174/1389557520666200619121003.

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α-Glucosidase plays an important role in carbohydrate metabolism and is an attractive drug target for the treatment of diabetes, obesity and other related complications. Currently, acarbose, miglitol and voglibose have been approved by the FDA for the treatment of diabetes by oral α-glucosidase inhibitors. With the development of anti-diabetic drugs, the emergence of novel drugs with various chemotypes has overshadowed α-glucosidase inhibitors. Since the 1990s, the FDA has not approved new chemical entities against α-glucosidase, which has resulted in restricted clinical medication. Neverthele

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Yang, Xinyu, Dan Wang, Yangyong Dai, Luping Zhao, Wentao Wang та Xiuzhen Ding. "Identification and Molecular Binding Mechanism of Novel α-Glucosidase Inhibitory Peptides from Hot-Pressed Peanut Meal Protein Hydrolysates". Foods 12, № 3 (2023): 663. http://dx.doi.org/10.3390/foods12030663.

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Hot-pressed peanut meal protein hydrolysates are rich in Arg residue, but there is a lack of research on their α-glucosidase inhibitory activity. In this study, different proteases were used to produce hot-pressed peanut meal protein hydrolysates (PMHs) to evaluate the α-glucosidase inhibitory activity. All PMHs showed good α-glucosidase inhibitory activity with the best inhibition effect coming from the dual enzyme system of Alcalase and Neutrase with an IC50 of 5.63 ± 0.19 mg/mL. The fractions with the highest inhibition effect were separated and purified using ultrafiltration and cation exc

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Ali, H., M. F. Abu Bakar, M. Majid, N. Muhammad, and S. Y. Lim. "In vitro anti-diabetic activity of stingless bee honey from different botanical origins." Food Research 4, no. 5 (2020): 1421–26. http://dx.doi.org/10.26656/fr.2017.4(5).411.

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The number of patients with diabetes mellitus is increasing at an alarming rate and this situation has triggered the interest of searching natural product as an alternative treatment. Stingless bee honey containing a diverse array of bioactive compounds is commonly utilized as a functional food and also found to possess various therapeutic effects including anti-diabetic through α-amylase and α-glucosidase inhibition. However, the composition level of bioactive compounds varying of geographical origins and botanical sources of honey leads to different enzyme inhibition abilities. Therefore, th

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26

Zhang, Ying, Yanna Pan, Jiaqi Li та ін. "Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum". Molecules 27, № 5 (2022): 1457. http://dx.doi.org/10.3390/molecules27051457.

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The prevention of postprandial hyperglycemia and diabetic complications is crucial for diabetes management. Inhibition of α-glucosidase to slow carbohydrate metabolism is a strategy to alleviate postprandial hyperglycemia. In addition, suppression of non-enzymatic glycation can diminish the advanced glycation end products and reduce the oxidative stress and inflammation, thereby preventing the diabetic complications. In this study, an anti-oxidative proteoglycan (named FYGL) extracted from Ganoderma lucidum was investigated in vitro for its inhibitory effect on α-glucosidase and non-enzymatic

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27

Hsu, Jui-Hung, Chang-Syun Yang та Jih-Jung Chen. "Antioxidant, Anti-α-Glucosidase, Antityrosinase, and Anti-Inflammatory Activities of Bioactive Components from Morus alba". Antioxidants 11, № 11 (2022): 2222. http://dx.doi.org/10.3390/antiox11112222.

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The root bark of Morus alba L. (Mori Cortex) is used to treat diuresis and diabetes in Chinese traditional medicine. We evaluated different solvent extracts and bioactive components from the root bark of Morus alba L. for their antioxidant, anti-α-glucosidase, antityrosinase, and anti-inflammatory activities. Acetone extract showed potent antioxidant activity, with SC50 values of 242.33 ± 15.78 and 129.28 ± 10.53 µg/mL in DPPH and ABTS radical scavenging assays, respectively. Acetone and ethyl acetate extracts exhibited the strongest anti-α-glucosidase activity, with IC50 values of 3.87 ± 1.95

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28

El Hosry, Leina, Souad Al Ayash, Jocelyne Matar Boumosleh, and Elias Bou-Maroun. "Chemical Composition, Antioxidant, and Anti-Diabetic Activities of Scorzonera phaeopappa Boiss." Stresses 3, no. 4 (2023): 773–84. http://dx.doi.org/10.3390/stresses3040053.

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Wild edible plants have attracted increasing interest from researchers because of their richness in biologically active phytochemicals. These are found to be a potential remedy for oxidative-stress-mediated diseases such as diabetes mellitus. In this study, total phenol, total terpene, and total flavonoid content as well as antioxidant and antidiabetic activities of Scorzonera phaeopappa Boiss from Lebanon were determined. Using dichloromethane, dichloromethane ammonia, methanol, acetone, and ethanol, extracts were prepared from the edible leaves. The antioxidant activity and the antidiabetic

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29

Muhammad Alfarabi, Maria Bintang, Suryani, Mega Safithri та Waras Nurcholis. "Kinetics of α -glucosidase inhibitory activity and phytochemical analysis of Piper crocatum Ruiz & Pav. leaves ethanol extract". International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 2032–36. http://dx.doi.org/10.26452/ijrps.v11ispl4.4416.

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α-Glucosidase is an enzymes group that playing essential roles in the digestion of polysaccharide. Inhibitor of a-glucosidase can decrease polysaccharide digestion rate and therefore plays a significant function in preventing the development of diabetes (type 2). Piper crocatum Ruiz & Pav. is an essential herb applied traditionally in Indonesia to treat diabetes mellitus. This work evaluated the a-glucosidase inhibitory activity of P. crocatum leaves ethanol extract. Phytochemical component of the extract was also analyzed. The α-glucosidase inhibitory activity of the P. crocatum leaves et

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Kato, Atsushi, Izumi Nakagome, Mizuki Hata та ін. "Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity". Molecules 25, № 12 (2020): 2843. http://dx.doi.org/10.3390/molecules25122843.

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Deoxynojirimycin (DNJ) is the archetypal iminosugar, in which the configuration of the hydroxyl groups in the piperidine ring truly mimic those of d-glucopyranose; DNJ and derivatives have beneficial effects as therapeutic agents, such as anti-diabetic and antiviral agents, and pharmacological chaperones for genetic disorders, because they have been shown to inhibit α-glucosidases from various sources. However, attempts to design a better molecule based solely on structural similarity cannot produce selectivity between α-glucosidases that are localized in multiple organs and tissues, because t

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Elya, Berna, Fitri S. Budiarso, Muhammad Hanafi, Maria A. Gani та Pekik W. Prasetyaningrum. "Two tetrahydroxyterpenoids and a flavonoid from Xylocarpus moluccensis M.Roem. and their α-glucosidase inhibitory and antioxidant capacity". Journal of Pharmacy & Pharmacognosy Research 12, № 3 (2024): 453–76. http://dx.doi.org/10.56499/jppres23.1816_12.3.453.

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Context: Scientific verification of the anti-hyperglycemic potential of Kayu sarampa (Xylocarpus moluccensis), which is popularly used for diabetic medication in North Sulawesi, Indonesia, is strongly important to conduct to avoid inappropriate medication that might cause worse conditions. Aims: To investigate the anti-hyperglycemic potential of X. moluccensis stem bark ethyl acetate extract and isolated compounds through the α-glucosidase enzyme inhibitory and antioxidant capacity determination. Methods: The active compound was isolated from ethyl acetate extract of X. moluccensis stem bark.

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Puspitasari, Yunita Eka, Hardoko Hardoko, Titik Dwi Sulistiyati, Alifah Nur Fajrin, and Hezkiel Oktorully Tampubolon. "Identifikasi Senyawa Fitokimia dari Daun Mangrove Sonneratia alba dan Analisis In Silico Sebagai Antidiabetes." Jurnal Perikanan dan Kelautan 27, no. 2 (2022): 241. http://dx.doi.org/10.31258/jpk.27.2.241-248.

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Mangrove plant, Sonneratia alba, can be found abundantly in Indonesia. Some previous studies reported phytochemical screening and bioactivity test of Sonneratia sp. as anti-diabetic (in vitro and in vivo analysis). However, phytochemical identification of S. alba leaves and inhibitory activity of α-glucosidase as anti-diabetic have not been reported. The purpose of this study are to identify phytochemical compounds of methanolic extracts S. alba leaves, and to predict inhibitory mechanisms of S. alba leaves against α-glucosidase through in silico analysis. In this study, the research method co

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Dong, Qi, Na Hu, Huilan Yue та Honglun Wang. "Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel α-Glucosidase Inhibitor". Molecules 26, № 15 (2021): 4566. http://dx.doi.org/10.3390/molecules26154566.

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α-glucosidase is a major enzyme that is involved in starch digestion and type 2 diabetes mellitus. In this study, the inhibition of hypericin by α-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time interaction analysis between hypericin and α-glucosidase by surface plasmon resonance (SPR), and molecular docking simulation. The results showed that hypericin was a high potential reversible and competitive α-glucosidase inhibitor, with a maximum half inhibitory concentration (IC50) of 4.66 ± 0.27 mg/L. The binding affinities of hypericin with α-gluco

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Lachowicz, Sabina, Rafał Wiśniewski, Ireneusz Ochmian, Katarzyna Drzymała, and Stanisław Pluta. "Anti-Microbiological, Anti-Hyperglycemic and Anti-Obesity Potency of Natural Antioxidants in Fruit Fractions of Saskatoon Berry." Antioxidants 8, no. 9 (2019): 397. http://dx.doi.org/10.3390/antiox8090397.

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The aim of the present work was to evaluate for content of phytochemicals (monophosphate nucleotides, free amino acids, polyphenols), and for anti-microbiological, anti-diabetic (ability to inhibit pancreatic lipase, α-glucosidase, and α-amylase), and antioxidant activities in seven selected fruit and fruit fractions of Amelanchier alnifolia. Most of the fruit and fruit fractions analyzed in this study have not been examined in this respect until now. The content of monophosphate nucleotides and free amino acids were tested by ultra-performance liquid chromatography coupled with photodiode arr

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Hu, Jingfei, Xiaohua Lai, Xudong Wu та ін. "Isolation of a Novel Anti-Diabetic α-Glucosidase Oligo-Peptide Inhibitor from Fermented Rice Bran". Foods 12, № 1 (2023): 183. http://dx.doi.org/10.3390/foods12010183.

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At present, the incidence rate of diabetes is increasing gradually, and inhibiting α-glucosidase is one of the effective methods used to control blood sugar. This study identified new peptides from rice bran fermentation broth and evaluated their inhibitory activity and mechanism against α-glucosidase. Rice bran was fermented with Bacillus subtilis MK15 and the polypeptides of <3 kDa were isolated by ultrafiltration and chromatographic column, and were then subjected to LC-MS/MS mass spectrometry analysis. The results revealed that the oligopeptide GLLGY showed the greatest inhibitory activ

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Abifarin, Taiwo Oluwafunmilola, Gloria Aderonke Otunola, and Anthony Jide Afolayan. "Cytotoxicity, Anti-Obesity and Anti-Diabetic Activities of Heteromorpha arborescens (Spreng.) Cham Leaves." Processes 9, no. 9 (2021): 1671. http://dx.doi.org/10.3390/pr9091671.

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This study investigated the cytotoxicity, anti-obesity and anti-diabetic potentials of blanched, aqueous and ethanol extracts of Heteromorpha arborescens (Spreng.) Cham leaves. The results revealed that both ethanol and aqueous extracts exhibited considerable inhibition against α-glucosidase (IC50 of 627.29 ± 4.62 µg/mL and 576.46 ± 3.21 µg/mL respectively), while the blanched extract showed weak α-glucosidase inhibition (IC50; 855.38 ± 4.29 µg/mL) and the aqueous extract showed the best α-amylase inhibition (IC50; 583.74 ± 5.87 µg/mL). However, weak α-amylase inhibition was observed in the et

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Chu, Yi-Cheng, Chang-Syun Yang, Ming-Jen Cheng, Shu-Ling Fu та Jih-Jung Chen. "Comparison of Various Solvent Extracts and Major Bioactive Components from Unsalt-Fried and Salt-Fried Rhizomes of Anemarrhena asphodeloides for Antioxidant, Anti-α-Glucosidase, and Anti-Acetylcholinesterase Activities". Antioxidants 11, № 2 (2022): 385. http://dx.doi.org/10.3390/antiox11020385.

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The rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) is a famous and frequently used herbal drug in the traditional medicine of Northeast Asia, under vernacular name “zhimu”. A. asphodeloides has been used as an anti-inflammatory, antipyretic, anti-platelet aggregation, anti-depressant, and anti-diabetic agent in traditional Chinese medicine. We examined the antioxidant, anti-acetylcholinesterase (AChE), and anti-α-glucosidase activities of various solvent extracts and the main bioactive compounds from the rhizome of A. asphodeloides. Acetone extract exhibited comparatively hi

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Tiwari, Palak, Nathiya R, and Gayathri Mahalingam. "ANTIDIABETIC ACTIVITY OF ENDOPHYTIC FUNGI ISOLATED FROM FICUS RELIGIOSA." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 59. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.14718.

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Objective- The aim was to study in vitro anti diabetic activity of endophytic fungi isolated from Ficus Religiosa.Method- The explants (leaves and stem) were processed on the potato dextrose media nine colonies was found and colony frequency was calculated. All the colonies were transferred onto potato dextrose broth and incubated for 21 days. The crude was extracted using three solvents petroleum ether (0.1), diethyl ether (2.8) and ethyl acetate (4.4). Three assays were performed to determine in vitro anti diabetic activity of crude extract (α-amylase inhibition assay, α-glucosidase inhibiti

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Djeujo, Francine Medjiofack, Valeria Francesconi, Maddalena Gonella, Eugenio Ragazzi, Michele Tonelli та Guglielmina Froldi. "Anti-α-Glucosidase and Antiglycation Activities of α-Mangostin and New Xanthenone Derivatives: Enzymatic Kinetics and Mechanistic Insights through In Vitro Studies". Molecules 27, № 2 (2022): 547. http://dx.doi.org/10.3390/molecules27020547.

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Diabetes mellitus is characterized by chronic hyperglycemia that promotes ROS formation, causing severe oxidative stress. Furthermore, prolonged hyperglycemia leads to glycation reactions with formation of AGEs that contribute to a chronic inflammatory state. This research aims to evaluate the inhibitory activity of α-mangostin and four synthetic xanthenone derivatives against glycation and oxidative processes and on α-glucosidase, an intestinal hydrolase that catalyzes the cleavage of oligosaccharides into glucose molecules, promoting the postprandial glycemic peak. Antiglycation activity was

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Cahya aulia tambunan, Gempita, Aparna Dutt, Sayra Nadhifa, Firdha Amelia, and Ermi Girsang. "The In Vitro Anti-Diabetic Activity of Lime Peels (Citrus amblycarpa (Hassk.) Ochse)." Journal of Health Sciences 13, no. 01 (2020): 26–33. http://dx.doi.org/10.33086/jhs.v13i01.1437.

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There are various potential natural anti-diabetic drugs; one of them is lime peel or Citrus amblycarpa. This study was aimed to explore the anti-diabetic activity and phytochemical content of lime peels. This study was an experimental study that used the post-test only control group design. The lime peels that were collected from the Berastagi fruit market in Medan, North Sumatera were extracted using 70% ethanol by maceration methods. The phytochemical screening identified the presence of phenolic, steroid/triterpenoid, terpenoid, saponin, flavonoid, tannin, and alkaloid. Meanwhile, the anti-

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Roseline, V. Priya, and V. Priya. "Antidiabetic Potential of Copper Oxide Nanoparticles Using Biological and Polymer Functionalized Method Mediated by Sarcostemma acidum Stem Extract." Oriental Journal Of Chemistry 39, no. 2 (2023): 387–92. http://dx.doi.org/10.13005/ojc/390218.

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The nano sized copper oxide material (CuONPs) were prepared by the greener way and an approach functionalized by polymer using Sarcostemma acidum stem extracts. The in-vitro anti-diabetic activity was studied through the α-glucosidase and α-amylase inhibitory methods were demonstrated in Sarcostemma acidum stem, biological synthesized CuONPs and polymerized CuONPs. The percentage inhibition at 100 μg/ml, 200 μg/ml, 300 μg/ml, 400 μg/ml and 500μg/ml concentrations of Sarcostemma acidum stem, biological synthesized and polymerised CuONPs showed dose dependent inhibition in α-amylase and α-glucos

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Lohitha, N., and V. Vijayakumar. "Synthesis, Characterization and Hypoglycemic Efficacy of Isonicotinohydrazide Phenoxy Quinolines: An in silico Studies." Asian Journal of Chemistry 34, no. 9 (2022): 2241–46. http://dx.doi.org/10.14233/ajchem.2022.23814.

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Prevention of α-amylase and β-glucosidase to reduce the postprandial blood sugar levels and delays dextrose absorption, the natural inhibitors provide an interesting approach to manage hyperglycemia with type 2 diabetes. The α-amylase and β-glucosidase are important therapeutic targets for type II diabetes. The isonicotinohydrazide phenoxy quinolines (5a-l) were synthesized and characterized by mass, 1H & 13C NMR. The characterized compounds are investigated for their in silico anti-hyperglycemic efficacy and the compounds shown effective to moderate inhibition against α-amylase and β-gluc

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Dutta, Subhajit, C. Ramesh, A. Madhu, Krishna Pundi, and B. A. Sowmya. "The ethanol extract of Muntingia calabura exhibits in vitro antidiabetic potentials by inhibiting carbohydrate digestive enzymes." Journal of Drug Delivery and Therapeutics 13, no. 11 (2023): 26–30. http://dx.doi.org/10.22270/jddt.v13i11.6276.

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Objective: The present research study was conducted to investigate in vitro anti-diabetic potentials of ethanol extract of leaves of Muntingia calabura for α-glucosidase and α-amylase inhibitory activities. Materials & Methods: The leaves of Muntingia calabura were collected and authenticated. dried and powdered. The powdered drug was defatted using petroleum ether and extracted with ethanol. The ethanol extract of Muntingia calabura was subjected to preliminary phytochemical investigation. The in vitro α-glucosidase inhibitory and α-amylase inhibitory properties were determined for

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Shulgau, Zarina, Irina Palamarchuk, Shynggys Sergazy та ін. "Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of Thiourea Derivatives Based on 3-Aminopyridin-2(1H)-Ones". Molecules 29, № 15 (2024): 3627. http://dx.doi.org/10.3390/molecules29153627.

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Reactions with allyl-, acetyl-, and phenylisothiocyanate have been studied on the basis of 3-amino-4,6-dimethylpyridine-2(1H)-one, 3-amino-4-phenylpyridine-2-one, and 3-amino-4-(thiophene-2-yl)pyridine-2(1H)-one (benzoyl-)isothiocyanates, and the corresponding thioureide derivatives 8-11a-c were obtained. Twelve thiourea derivatives were obtained and studied for their anti-diabetic activity against the enzyme α-glucosidase in comparison with the standard drug acarbose. The comparison drug acarbose inhibits the activity of α-glucosidase at a concentration of 15 mM by 46.1% (IC50 for acarbose is

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Chen, Shih-Chi, Chang-Syun Yang, and Jih-Jung Chen. "Main Bioactive Components and Their Biological Activities from Natural and Processed Rhizomes of Polygonum sibiricum." Antioxidants 11, no. 7 (2022): 1383. http://dx.doi.org/10.3390/antiox11071383.

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Polygonatum sibiricum (Asparagaceae) is often used as an herbal drug in the traditional medicine of Southeast Asia. Its rhizome, called “Huang Jing”, is used in traditional Chinese medicine as an immune system stimulant, hypolipidemic agent, anti-aging agent, anti-fatigue agent, and cardiovascular protectant. We investigated the antioxidant, anti-acetylcholinesterase (AChE), anti-inflammatory, and anti-α-glucosidase effects of various solvent extracts and major bioactive components of Polygonatum sibiricum (PS) and processed Polygonatum sibiricum (PPS). Dichloromethane extract of PS showed str

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Kokanova-Nedialkova, Zlatina, Magdalena Kondeva-Burdina та Paraskev Nedialkov. "Saponins from the roots of Chenopodium bonus-henricus L. with neuroprotective and anti-α-glucosidase activities". Pharmacia 68, № 2 (2021): 387–92. http://dx.doi.org/10.3897/pharmacia.68.e64425.

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Six saponins of phytolaccagenin, bayogenin, medicagenic acid, 2β-hydroxygypsogenin, and 2β-hydroxyoleanoic acid from the roots of Chenopodium bonus-henricus L. were investigated for neuroprotective and anti-α-glucosidase activities. All tested saponins (10 µM) showed statistically significant neuroprotective activities on isolated rat brain synaptosomes using a 6-hydroxydopamine in vitro model. They preserved synaptosome viability as well as the reduced glutathione level. The bayogenin glycoside (Chbhs-05) possessed the most prominent neuroprotective effect. The anti-α-glucosidase activity of

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Kokanova-Nedialkova, Zlatina, Magdalena Kondeva-Burdina та Paraskev Nedialkov. "Saponins from the roots of Chenopodium bonus-henricus L. with neuroprotective and anti-α-glucosidase activities". Pharmacia 68, № (2) (2021): 387–92. https://doi.org/10.3897/pharmacia.68.e64425.

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Six saponins of phytolaccagenin, bayogenin, medicagenic acid, 2β-hydroxygypsogenin, and 2β-hydroxyoleanoic acid from the roots of Chenopodium bonus-henricus L. were investigated for neuroprotective and anti-α-glucosidase activities. All tested saponins (10 µM) showed statistically significant neuroprotective activities on isolated rat brain synaptosomes using a 6-hydroxydopamine in vitro model. They preserved synaptosome viability as well as the reduced glutathione level. The bayogenin glycoside (Chbhs-05) possessed the most prominent neuroprotective effect. The anti-α-glucosidase activity of

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Shervinjose, S., R. Roshinee, G. M. Vishal Bharathi, et al. "Phytochemical analysis, in vitro Anti-diabetic and Anti-inflammatory activity of Chloroform extract of Artocarpus hirsutus Root." International Journal of Current Microbiology and Applied Sciences 14, no. 2 (2025): 136–43. https://doi.org/10.20546/ijcmas.2025.1402.012.

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The incidence and prevalence of diabetes mellitus have risen significantly in recent decades. Our study therefore concentrated on evaluating the phytochemical analysis, anti-inflammatory activity, and antidiabetic activity. Enzyme inhibition has antidiabetic effects in vitro, while protein denaturation produces anti-inflammatory effects. Reducing the synthesis and absorption of glucose in the gastrointestinal tract by inhibiting enzymes that break down carbohydrates, such as α-amylase and α-glucosidase, is one method of treating diabetes. A key approach in blood glucose management is the inhib

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Nagaraju Jesetti, Rajasekhar Reddy Alavala, Subhakar Raju Rapaka, Umasankar Kulandaivelu, and Koteswara Rao GSN. "Antidiabetic activity, alpha-amylase, and alpha-glucosidase inhibitory effect of Tradescantia spathacea Swartz extract." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1594–99. http://dx.doi.org/10.26452/ijrps.v11ispl4.4343.

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Tradescantia spathacea Swartz belongs to the genus Commelinaceae, a tropical tree used in many countries as an herbal drug for the care of diabetic patients. The aim of this study was to examine anti-diabetic activity of the Tradescantia spathacea Swartz methanolic extract (METSW) and the in-vitro activity of α-amylase, and α-glucosidase was carried out. METSW compared with acarbose inhibition of the α-amylase and α-glucosidase enzyme, METSW exhibited IC50 less than 100μg/mL would be considered as healthy. The METSW showed IC50 66.22 ± 0.52μg/mL α-amylase activity, acarbose revealed an IC50 of

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Liang, Jia-Hua, Hsiang-Ru Lin, Chang-Syun Yang, Chia-Ching Liaw, I.-Chou Wang та Jih-Jung Chen. "Bioactive Components from Ampelopsis japonica with Antioxidant, Anti-α-Glucosidase, and Antiacetylcholinesterase Activities". Antioxidants 11, № 7 (2022): 1228. http://dx.doi.org/10.3390/antiox11071228.

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The dried root of Ampelopsis japonica (Thunb.) Makino (A. japonica.) is a traditional medicine used to treat fever, pain, and wound healing. It exhibits anti-inflammatory, antitumor, antityrosinase, and antimelanogenic activities. In this paper, we used different solvent extracts from the root of A. japonica to determine their antioxidant activity. Acetone extract showed relatively strong antioxidant properties by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl (DPPH), superoxide radical scavenging activity, and ferric reducing antio

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