Academic literature on the topic 'Anti-Adipogenic action'

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Journal articles on the topic "Anti-Adipogenic action"

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Vasileva, Liliya, Martina Savova, Daniel Tews, Martin Wabitsch, and Milen Georgiev. "Rosmarinic acid attenuates obesity and obesity-related inflammation in human adipocytes." Food and Chemical Toxicology 149 (January 19, 2021): 112002. https://doi.org/10.1016/j.fct.2021.112002.

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Chronic low-grade inflammation is a hallmark of obesity and its related metabolic disorders. At the same time signaling from pro-inflammatory factors such as transforming growth factor beta (TGF-β) or interleukin 17A (IL- 17A) are proposed as crucial for the commitment of fibroblast progenitor cells towards adipogenic differentiation. Modulation of inflammation during adipogenic differentiation is incompletely explored as a potential approach to prevent metabolic disorders. Rosmarinic acid (RA) is a caffeic acid derivative known for its antiinflammatory effects. Experimental studies of it
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Oh, Jung Hwan, Fatih Karadeniz, Mi-Soon Jang, Hojun Kim, Youngwan Seo та Chang-Suk Kong. "Loliolide from Artemisia princeps Suppresses Adipogenesis in Human Bone Marrow-Derived Mesenchymal Stromal Cells via Activation of AMPK and Wnt/β-catenin Pathways". Applied Sciences 11, № 12 (2021): 5435. http://dx.doi.org/10.3390/app11125435.

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Regulating the adipogenic differentiation mechanism is a valid and promising mechanism to battle obesity. Natural products, especially phytochemicals as nutraceuticals, are important lead molecules with significant activities against obesity. Loliolide is a monoterpenoid hydroxyl lactone found in many dietary plants. The effect of loliolide on adipogenic differentiation is yet to be determined. Therefore, the present study aimed to evaluate its anti-adipogenic potential using human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) and assess its mechanism of action. Adipo-induced hBM-MS
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Gautam, Jyoti, Vikram Khedgikar, Priyanka Kushwaha та ін. "Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss". British Journal of Nutrition 117, № 5 (2017): 645–61. http://dx.doi.org/10.1017/s0007114517000149.

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AbstractBalance between adipocyte and osteoblast differentiation is the key link of disease progression in obesity and osteoporosis. We have previously reported that formononetin (FNT), an isoflavone extracted from Butea monosperma, stimulates osteoblast formation and protects against postmenopausal bone loss. The inverse relationship between osteoblasts and adipocytes prompted us to analyse the effect of FNT on adipogenesis and in vivo bone loss, triggered by high-fat diet (HFD)-induced obesity. The anti-obesity effect and mechanism of action of FNT was determined in 3T3-L1 cells and HFD-indu
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Mladenova, Saveta, Martina Savova, Andrey Marchev та ін. "Anti-adipogenic activity of maackiain and ononin is mediated via inhibition of PPARγ in human adipocytes". Biomedicine & Pharmacotherapy 149 (1 квітня 2022): 112908. https://doi.org/10.1016/j.biopha.2022.112908.

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Obesity is a global health burden for which we do not yet have effective treatments for prevention or therapy. Plants are an invaluable source of bioactive leads possessing anti-adipogenic potential. Ethnopharmacological use of Ononis spinosa L. roots (OSR) for treatment of obesity and metabolic disorders requires а scientific rationale. The current study examined the anti-adipogenic capacity of OSR and its secondary metabolites ononin (ONON) and maackiain (MACK) in human adipocytes as an in vitro model of obesity. Both ONON and MACK diminished lipid accumulation during adipocyte differentiati
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Lee, Jung Im, Jung Hwan Oh, Fatih Karadeniz, Chang-Suk Kong, and Youngwan Seo. "Inhibitory Effects of Sesquiterpenoids Isolated from Artemisia scoparia on Adipogenic Differentiation of 3T3-L1 Preadipocytes." International Journal of Molecular Sciences 25, no. 1 (2023): 200. http://dx.doi.org/10.3390/ijms25010200.

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Obesity and related complications are significant health issues in modern society, largely attributed to a sedentary lifestyle and a carbohydrate-rich diet. Since anti-obesity drugs often come with severe side effects, preventative measures are being sought globally, including dietary changes and functional foods that can counteract weight gain. In this context, plant-based metabolites are extensively studied for their advantageous biological effects against obesity. Several plants within the Artemisia genus have been reported to possess anti-adipogenic properties, preventing adipocytes from m
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Ono, Tomoji, Satoru Morishita, Chikako Fujisaki, et al. "Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fat." British Journal of Nutrition 105, no. 2 (2010): 200–211. http://dx.doi.org/10.1017/s0007114510003259.

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Lactoferrin (LF) is a multifunctional glycoprotein in mammalian milk. In a previous report, we showed that enteric-coated bovine LF tablets can decrease visceral fat accumulation, hypothesising that the enteric coating is critical to the functional peptides reaching the visceral fat tissue and exerting their anti-adipogenic activity. The aim of the present study was to assess whether ingested LF can retain its anti-adipogenic activity. We therefore investigated the effects of LF and LF treated with digestive enzymes (the stomach enzyme pepsin and the small intestine enzyme trypsin) on lipid ac
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Kim, Nari, Sekyung Lee, Eun-Jin Jung та ін. "Yeast-Hydrolysate-Derived 1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic Acid Inhibits Fat Accumulation during Adipocyte Differentiation". Foods 12, № 18 (2023): 3466. http://dx.doi.org/10.3390/foods12183466.

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This study aimed to investigate the impact of yeast hydrolysate (YH) on lipogenesis, elucidate its mechanistic action, and identify the active compounds responsible for its anti-adipogenic effects. YH (2 mg/mL) significantly reduced Oil Red O-stained lipids. YH (2 mg/mL) also downregulated C/EBPβ and upregulated KLF2, both of which are early adipogenic factors. Moreover, YH (2 mg/mL) decreased C/EBPα, PPARγ, FABP4, FAS, ACC, and HMGCR mRNA expression. Additionally, YH significantly downregulated SEBP1c and SREBP2 and their target genes, which govern fatty acid and cholesterol metabolism; howev
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Mladenova, Saveta, Liliya Vasileva, Martina Savova, et al. "Anti-Adipogenic Effect of Alchemilla monticola is Mediated Via PI3K/AKT Signaling Inhibition in Human Adipocytes." Frontiers in Pharmacology 12 (August 18, 2021): 707507. https://doi.org/10.3389/fphar.2021.707507.

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Obesity is a persistent and continuously expanding social health concern. Excessive fat mass accumulation is associated with increased risk of chronic diseases including diabetes, atherosclerosis, non-alcoholic steatohepatitis, reproductive dysfunctions and certain types of cancer.&nbsp;<em>Alchemilla monticola</em>&nbsp;Opiz. is a perennial plant of the Rosaceae family traditionally used to treat inflammatory conditions and as a component of weight loss herbal mixtures. In the search for bioactive leads with potential anti-adipogenic effect from&nbsp;<em>A. monticola</em>&nbsp;extract (ALM),
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Yadav, Anil Kumar, and Byeong-Churl Jang. "Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2." International Journal of Molecular Sciences 23, no. 13 (2022): 7274. http://dx.doi.org/10.3390/ijms23137274.

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Casein kinase 2 (CK2) is a ubiquitously expressed serine/threonine kinase and is upregulated in human obesity. CX-4945 (Silmitasertib) is a CK2 inhibitor with anti-cancerous and anti-adipogenic activities. However, the anti-adipogenic and pro-lipolytic effects and the mode of action of CX-4945 in (pre)adipocytes remain elusive. Here, we explored the effects of CX-4945 on adipogenesis and lipolysis in differentiating and differentiated 3T3-L1 cells, a murine preadipocyte cell line. CX-4945 at 15 μM strongly reduced lipid droplet (LD) accumulation and triglyceride (TG) content in differentiating
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Dhok, Mayuri, Avinash Kharat, Ramesh Bhonde, and Nilima Ghangale. "Evidence based Osteogenic, anti adipogenic and anti- senescence action of Centella asiatica extract on Dental pulp stem cells." International Journal of Ayurvedic Medicine 15, no. 3 (2024): 684–88. http://dx.doi.org/10.47552/ijam.v15i3.4879.

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Aim: Centella asiatica linn family of Apiaceae has been used as a traditional medicine as anti-aging remedy to minimize the severity of aging problems. However the effects of Centella asiatica on stem cell differentiation and anti-aging activity are not fully understood. In this investigation we tested the effect of an aqueous extract of Centella asiatica on senescence and osteogenic, chondrogenic and adipogenic differentiation of human dental pulp stem cells ( hDPSCs). Methods: DPSC (n = 10) from the human pulp was treated with various concentrations of Centella asiatica(CA). The cytotoxicity
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Book chapters on the topic "Anti-Adipogenic action"

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Novaes, F. J. M., M. A. E. Silva, C. Miceli Filho, et al. "Cafestol and Kahweol." In Coffee and Human Health. Royal Society of Chemistry, 2025. https://doi.org/10.1039/9781839166853-00071.

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Cafestol and kahweol (C&amp;K) are intriguing molecules that reveal part of the chemical history of coffee and its agribusiness stages, extending beyond the final cup of coffee. Present as oil bodies in all parts of the coffee plant, these compounds are concentrated in the fruit and are believed to play a defensive role for the plant. They are primarily stored in an esterified form and transferred from the endocarp to the seedling during germination. C&amp;K are partially degraded during coffee bean roasting, depending on temperature and exposure time; partially extracted into beverages, depen
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Conference papers on the topic "Anti-Adipogenic action"

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Ibrahim, Khadega, Chiara Cugno, and Md Mizanur Rahman. "Conjugated Linoleic Acid (CLA) co-treatment alleviates antidiabetic drug, rosiglitazone associated deterioration of bone remodeling." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0148.

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Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to decreased insulin secretion, defective action or both. The rosiglitazone (RSG) is one of the oral antidiabetic drug used in type 2 (T2) DM and has a unique insulin-sensitizing capacity. However, RSG has a negative side effect on the bone as it stimulates the differentiation of bone marrow-mesenchymal stromal cells (BM-MSCs) into adipocytes at the expense of osteoblasts in the bone marrow microenvironment, disturbing the normal balance of bone remodeling and causing BM adiposity. On the other hand, the t
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