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Journal articles on the topic 'Anti-Adipogenic action'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Vasileva, Liliya, Martina Savova, Daniel Tews, Martin Wabitsch, and Milen Georgiev. "Rosmarinic acid attenuates obesity and obesity-related inflammation in human adipocytes." Food and Chemical Toxicology 149 (January 19, 2021): 112002. https://doi.org/10.1016/j.fct.2021.112002.

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Chronic low-grade inflammation is a hallmark of obesity and its related metabolic disorders. At the same time signaling from pro-inflammatory factors such as transforming growth factor beta (TGF-β) or interleukin 17A (IL- 17A) are proposed as crucial for the commitment of fibroblast progenitor cells towards adipogenic differentiation. Modulation of inflammation during adipogenic differentiation is incompletely explored as a potential approach to prevent metabolic disorders. Rosmarinic acid (RA) is a caffeic acid derivative known for its antiinflammatory effects. Experimental studies of it

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Oh, Jung Hwan, Fatih Karadeniz, Mi-Soon Jang, Hojun Kim, Youngwan Seo та Chang-Suk Kong. "Loliolide from Artemisia princeps Suppresses Adipogenesis in Human Bone Marrow-Derived Mesenchymal Stromal Cells via Activation of AMPK and Wnt/β-catenin Pathways". Applied Sciences 11, № 12 (2021): 5435. http://dx.doi.org/10.3390/app11125435.

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Regulating the adipogenic differentiation mechanism is a valid and promising mechanism to battle obesity. Natural products, especially phytochemicals as nutraceuticals, are important lead molecules with significant activities against obesity. Loliolide is a monoterpenoid hydroxyl lactone found in many dietary plants. The effect of loliolide on adipogenic differentiation is yet to be determined. Therefore, the present study aimed to evaluate its anti-adipogenic potential using human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) and assess its mechanism of action. Adipo-induced hBM-MS

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Gautam, Jyoti, Vikram Khedgikar, Priyanka Kushwaha та ін. "Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss". British Journal of Nutrition 117, № 5 (2017): 645–61. http://dx.doi.org/10.1017/s0007114517000149.

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AbstractBalance between adipocyte and osteoblast differentiation is the key link of disease progression in obesity and osteoporosis. We have previously reported that formononetin (FNT), an isoflavone extracted from Butea monosperma, stimulates osteoblast formation and protects against postmenopausal bone loss. The inverse relationship between osteoblasts and adipocytes prompted us to analyse the effect of FNT on adipogenesis and in vivo bone loss, triggered by high-fat diet (HFD)-induced obesity. The anti-obesity effect and mechanism of action of FNT was determined in 3T3-L1 cells and HFD-indu

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Mladenova, Saveta, Martina Savova, Andrey Marchev та ін. "Anti-adipogenic activity of maackiain and ononin is mediated via inhibition of PPARγ in human adipocytes". Biomedicine & Pharmacotherapy 149 (1 квітня 2022): 112908. https://doi.org/10.1016/j.biopha.2022.112908.

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Obesity is a global health burden for which we do not yet have effective treatments for prevention or therapy. Plants are an invaluable source of bioactive leads possessing anti-adipogenic potential. Ethnopharmacological use of Ononis spinosa L. roots (OSR) for treatment of obesity and metabolic disorders requires а scientific rationale. The current study examined the anti-adipogenic capacity of OSR and its secondary metabolites ononin (ONON) and maackiain (MACK) in human adipocytes as an in vitro model of obesity. Both ONON and MACK diminished lipid accumulation during adipocyte differentiati

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Lee, Jung Im, Jung Hwan Oh, Fatih Karadeniz, Chang-Suk Kong, and Youngwan Seo. "Inhibitory Effects of Sesquiterpenoids Isolated from Artemisia scoparia on Adipogenic Differentiation of 3T3-L1 Preadipocytes." International Journal of Molecular Sciences 25, no. 1 (2023): 200. http://dx.doi.org/10.3390/ijms25010200.

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Obesity and related complications are significant health issues in modern society, largely attributed to a sedentary lifestyle and a carbohydrate-rich diet. Since anti-obesity drugs often come with severe side effects, preventative measures are being sought globally, including dietary changes and functional foods that can counteract weight gain. In this context, plant-based metabolites are extensively studied for their advantageous biological effects against obesity. Several plants within the Artemisia genus have been reported to possess anti-adipogenic properties, preventing adipocytes from m

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Ono, Tomoji, Satoru Morishita, Chikako Fujisaki, et al. "Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fat." British Journal of Nutrition 105, no. 2 (2010): 200–211. http://dx.doi.org/10.1017/s0007114510003259.

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Lactoferrin (LF) is a multifunctional glycoprotein in mammalian milk. In a previous report, we showed that enteric-coated bovine LF tablets can decrease visceral fat accumulation, hypothesising that the enteric coating is critical to the functional peptides reaching the visceral fat tissue and exerting their anti-adipogenic activity. The aim of the present study was to assess whether ingested LF can retain its anti-adipogenic activity. We therefore investigated the effects of LF and LF treated with digestive enzymes (the stomach enzyme pepsin and the small intestine enzyme trypsin) on lipid ac

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Kim, Nari, Sekyung Lee, Eun-Jin Jung та ін. "Yeast-Hydrolysate-Derived 1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic Acid Inhibits Fat Accumulation during Adipocyte Differentiation". Foods 12, № 18 (2023): 3466. http://dx.doi.org/10.3390/foods12183466.

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This study aimed to investigate the impact of yeast hydrolysate (YH) on lipogenesis, elucidate its mechanistic action, and identify the active compounds responsible for its anti-adipogenic effects. YH (2 mg/mL) significantly reduced Oil Red O-stained lipids. YH (2 mg/mL) also downregulated C/EBPβ and upregulated KLF2, both of which are early adipogenic factors. Moreover, YH (2 mg/mL) decreased C/EBPα, PPARγ, FABP4, FAS, ACC, and HMGCR mRNA expression. Additionally, YH significantly downregulated SEBP1c and SREBP2 and their target genes, which govern fatty acid and cholesterol metabolism; howev

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Mladenova, Saveta, Liliya Vasileva, Martina Savova, et al. "Anti-Adipogenic Effect of Alchemilla monticola is Mediated Via PI3K/AKT Signaling Inhibition in Human Adipocytes." Frontiers in Pharmacology 12 (August 18, 2021): 707507. https://doi.org/10.3389/fphar.2021.707507.

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Obesity is a persistent and continuously expanding social health concern. Excessive fat mass accumulation is associated with increased risk of chronic diseases including diabetes, atherosclerosis, non-alcoholic steatohepatitis, reproductive dysfunctions and certain types of cancer. <em>Alchemilla monticola</em> Opiz. is a perennial plant of the Rosaceae family traditionally used to treat inflammatory conditions and as a component of weight loss herbal mixtures. In the search for bioactive leads with potential anti-adipogenic effect from <em>A. monticola</em> extract (ALM),

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Yadav, Anil Kumar, and Byeong-Churl Jang. "Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2." International Journal of Molecular Sciences 23, no. 13 (2022): 7274. http://dx.doi.org/10.3390/ijms23137274.

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Casein kinase 2 (CK2) is a ubiquitously expressed serine/threonine kinase and is upregulated in human obesity. CX-4945 (Silmitasertib) is a CK2 inhibitor with anti-cancerous and anti-adipogenic activities. However, the anti-adipogenic and pro-lipolytic effects and the mode of action of CX-4945 in (pre)adipocytes remain elusive. Here, we explored the effects of CX-4945 on adipogenesis and lipolysis in differentiating and differentiated 3T3-L1 cells, a murine preadipocyte cell line. CX-4945 at 15 μM strongly reduced lipid droplet (LD) accumulation and triglyceride (TG) content in differentiating

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Dhok, Mayuri, Avinash Kharat, Ramesh Bhonde, and Nilima Ghangale. "Evidence based Osteogenic, anti adipogenic and anti- senescence action of Centella asiatica extract on Dental pulp stem cells." International Journal of Ayurvedic Medicine 15, no. 3 (2024): 684–88. http://dx.doi.org/10.47552/ijam.v15i3.4879.

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Aim: Centella asiatica linn family of Apiaceae has been used as a traditional medicine as anti-aging remedy to minimize the severity of aging problems. However the effects of Centella asiatica on stem cell differentiation and anti-aging activity are not fully understood. In this investigation we tested the effect of an aqueous extract of Centella asiatica on senescence and osteogenic, chondrogenic and adipogenic differentiation of human dental pulp stem cells ( hDPSCs). Methods: DPSC (n = 10) from the human pulp was treated with various concentrations of Centella asiatica(CA). The cytotoxicity

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Kim, Jong-Yeon, Eun-Jung Park, and Hae-Jeung Lee. "Ameliorative Effects of Lactobacillus plantarum HAC01 Lysate on 3T3-L1 Adipocyte Differentiation via AMPK Activation and MAPK Inhibition." International Journal of Molecular Sciences 23, no. 11 (2022): 5901. http://dx.doi.org/10.3390/ijms23115901.

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Lactobacillus plantarum HAC01 has been shown to effectively treat metabolic diseases. However, the precise pharmacological effects and molecular mechanisms of L. plantarum HAC01 remain unclear. In this study, we investigate the anti-adipogenic effects of L. plantarum HAC01 lysate and its associated mechanism of action. To induce lipid accumulation, 3T3-L1 cells were incubated in differentiation media with or without L. plantarum HAC01 lysate. Our results show that L. plantarum HAC01 lysate treatment not only reduced lipid accumulation during the differentiation of 3T3-L1 cells, but also decrea

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Karadeniz, Fatih, Jung Hwan Oh, Mi Soon Jang, Youngwan Seo, and Chang-Suk Kong. "Libanoridin Isolated from Corydalis heterocarpa Inhibits Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells." International Journal of Molecular Sciences 24, no. 1 (2022): 254. http://dx.doi.org/10.3390/ijms24010254.

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Bone marrow adiposity is a complication in osteoporotic patients. It is a result of the imbalance between adipogenic and osteogenic differentiation of bone marrow cells. Phytochemicals can alleviate osteoporotic complications by hindering bone loss and decreasing bone marrow adiposity. Corydalis heterocarpa is a biennial halophyte with reported bioactivities, and it is a source of different coumarin derivatives. Libanoridin is a coumarin isolated from C. heterocarpa, and the effect of libanoridin on adipogenic differentiation of human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) wa

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Kim, Ji Hye, Mi Jeong Jo, Hye Jin Go, Nam Gyu Park, and Gun Do Kim. "Anti-adipogenic effect of mastoparan B analogue peptide on 3T3-L1 preadipocytes." Bangladesh Journal of Pharmacology 13, no. 4 (2018): 333–39. http://dx.doi.org/10.3329/bjp.v13i4.37351.

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Mastoparan B (MP-B), a cationic tetradecapeptide isolated from the venom of the Vespa basalis, exhibits cardiovascular effects, local edema and antibacterial activity. In this study, the anti-adipogenic effect of an MP-B analogue and its mechanism of action in 3T3-L1 preadipocytes were studied. The MP-B analogue (MP-B12) inhibited preadipocyte differentiation and decreased the expression of adipogenic transcription factors, including CCAAT/enhancer binding protein-alpha (C/EBPα), nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) and sterol regulatory element-binding pro

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Chayaratanasin, Poramin, Allen Caobi, Chaturong Suparpprom, et al. "Clitoria ternatea Flower Petal Extract Inhibits Adipogenesis and Lipid Accumulation in 3T3-L1 Preadipocytes by Downregulating Adipogenic Gene Expression." Molecules 24, no. 10 (2019): 1894. http://dx.doi.org/10.3390/molecules24101894.

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Clitoria ternatea (commonly known as blue pea) flower petal extract (CTE) is used as a natural colorant in a variety of foods and beverages. The objective of study was to determine the inhibitory effect of CTE on adipogenesis in 3T3-L1 preadipocytes. The phytochemical profiles of CTE were analyzed by liquid chromatography and tandem mass spectrometry (LC-MS/MS). Anti-adipogenesis effect of CTE was measured by using Oil Red O staining, intracellular triglyceride assay, quantitative real-time PCR and western blot analysis in 3T3-L1 adipocytes. Cell cycle studies were performed by flow cytometry.

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Hyun, Jimin, Hyo-Geun Lee, Jun-Geon Je, et al. "L-Fucose-Rich Sulfated Glycans from Edible Brown Seaweed: A Promising Functional Food for Obesity and Energy Expenditure Improvement." International Journal of Molecular Sciences 25, no. 17 (2024): 9738. http://dx.doi.org/10.3390/ijms25179738.

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The global obesity epidemic, exacerbated by the sedentary lifestyle fostered by the COVID-19 pandemic, presents a growing socioeconomic burden due to decreased physical activity and increased morbidity. Current obesity treatments show promise, but they often come with expensive medications, frequent injections, and potential side effects, with limited success in improving obesity through increased energy expenditure. This study explores the potential of a refined sulfated polysaccharide (SPSL), derived from the brown seaweed Scytosiphon lomentaria (SL), as a safe and effective anti-obesity tre

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Martineau, Louis, Jessica Hervé, Asim Muhamad, et al. "Anti-adipogenic Activities ofAlnus incanaandPopulus balsamiferaBark Extracts, Part I: Sites and Mechanisms of Action." Planta Medica 76, no. 13 (2010): 1439–46. http://dx.doi.org/10.1055/s-0029-1240941.

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Gagnon, AnneMarie, Charlie Foster, Anne Landry та Alexander Sorisky. "The role of interleukin 1β in the anti-adipogenic action of macrophages on human preadipocytes". Journal of Endocrinology 217, № 2 (2013): 197–206. http://dx.doi.org/10.1530/joe-12-0565.

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When adipose tissue accumulates in obesity, the ability of preadipocytes to differentiate permits a hyperplastic expansion of functional adipocytes that preserves insulin sensitivity. Adipose infiltration by macrophages is associated with an adipogenic deficit and the appearance of inflamed, insulin-resistant hypertrophied adipocytes. Interleukin 1β (IL1β) has been reported to account for the anti-adipogenic action of macrophages in a mouse model. Using the THP-1 human macrophage cell line and human primary preadipocytes, our objective was to determine whether IL1β was necessary for the abilit

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Jakab, Jelena, Milorad Zjalić, Štefica Mikšić, et al. "Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors." Current Issues in Molecular Biology 43, no. 3 (2021): 2082–97. http://dx.doi.org/10.3390/cimb43030144.

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Obesity is a multifactorial chronic disease characterized by the excessive accumulation of fat in adipose tissue driven by hypertrophy and hyperplasia of adipocytes through adipogenesis. Adipogenesis plays a key role in the development of obesity and related metabolic disorders, which makes it potential target for the therapeutic approach to obesity. An increasing number of studies confirm the pleiotropic action of the combined treatment with metformin and statins, suggesting their anti-hypertensive, anti-inflammatory, and anti-adipogenic effect. The aim of this study was to analyze the effect

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Krongyut, Ornnicha, and Khaetthareeya Sutthanut. "Phenolic Profile, Antioxidant Activity, and Anti-obesogenic Bioactivity of Mao Luang Fruits (Antidesma bunius L.)." Molecules 24, no. 22 (2019): 4109. http://dx.doi.org/10.3390/molecules24224109.

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To investigate the anti-obesity potential of Antidesma bunius L. (MM), a Thai local fruit which is named “Mao Luang,” we have focused on the effects on pancreatic α-amylase and lipase enzyme activity and on adipocyte life cycle using the 3T3-L1 cell line as a model. In addition, the phytochemical composition and anti-oxidation potential were also analyzed using HPLC-PDA UV and colorimetric methods. The ethanolic extract of MM fruits prepared by a maceration method was used in the experiments. MM extract, yield 12.08% w/w, is composed primarily of phenolics and anthocyanins as the major phytoch

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Nicholson, A. C., D. P. Hajjar, X. Zhou, W. He, A. M. Gotto та J. Han. "Anti-adipogenic action of pitavastatin occurs through the coordinate regulation of PPARγ and Pref-1 expression". British Journal of Pharmacology 151, № 6 (2007): 807–15. http://dx.doi.org/10.1038/sj.bjp.0707250.

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Yang, Hee, Min Jeong Kang, Gihyun Hur та ін. "Sulforaphene Suppresses Adipocyte Differentiation via Induction of Post-Translational Degradation of CCAAT/Enhancer Binding Protein Beta (C/EBPβ)". Nutrients 12, № 3 (2020): 758. http://dx.doi.org/10.3390/nu12030758.

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Adipocyte differentiation (adipogenesis) is a crucial process that determines the total number and size of mature adipocytes that will develop. In this study, the anti-adipogenic effect of sulforaphene (SFEN), a dietary isothiocyanate (ITC) derived from radish, is investigated both in 3T3-L1 pre-adipocytes and in human adipose tissue-derived stem cells. The results revealed that SFEN significantly inhibit adipogenic cocktail-induced adipocyte differentiation and lipid accumulation at the early stage of adipogenesis. Additionally, the effects are more potent compared to those of other ITCs deri

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Yu, Mi-Hee, Yun-Jeong Jeong, Sung Wook Son та ін. "Ascochlorin Attenuates the Early Stage of Adipogenesis via the Wnt/β-Catenin Pathway and Inhibits High-Fat-Diet-Induced Obesity in Mice". International Journal of Molecular Sciences 25, № 18 (2024): 10226. http://dx.doi.org/10.3390/ijms251810226.

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This study investigated the effects of ascochlorin (ASC), a natural compound derived from the fungus Ascochyta viciae, on adipogenesis and obesity. We determined the effects of ASC on 3T3-L1 preadipocytes and whether it ameliorated to mitigate high-fat diet (HFD)-induced obesity in C57BL/6J mice. We found that ASC significantly inhibited the differentiation of preadipocytes by modulating the Wnt/β-catenin signaling pathway, a key regulator of adipogenic processes. Treatment with ASC not only reduced the mRNA and protein expression of key adipogenic transcription factors such as C/EBPα and PPAR

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Ali, Heidari, Meftahi Gholamhosein, Bahrami Farideh, et al. "Anti-Adipogenic Effects of Eryngium billardieri Extract during 3T3-L1 Adipocyte Differentiation." Journal of Advances in Medical and Biomedical Research 31, no. 147 (2023): 391–97. https://doi.org/10.30699/jambs.31.147.391.

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<strong>Abstract:</strong>   <strong>Background and Objective: </strong>Obesity is a major public health problem whose prevalence has constantly increased worldwide. Obesity is a risk factor for several diseases such as type 2 diabetes, fatty liver disease, hyperlipidemia, cardiovascular diseases, and cancer, all of which reduce the quality of life and life expectancy. This study investigated anti-adipogenic effects of <i>Eryngium billardierei</i> (Ery) extract.<strong>Materials and Methods: </strong>The nontoxic concentration of Ery extract was estimated via the 3-(4,5-dim

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Park, In Sil, Boyun Kim, Youngjin Han та ін. "Decursin and Decursinol Angelate Suppress Adipogenesis through Activation of β-catenin Signaling Pathway in Human Visceral Adipose-Derived Stem Cells". Nutrients 12, № 1 (2019): 13. http://dx.doi.org/10.3390/nu12010013.

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Visceral adiposity is closely associated with metabolic disorders and cardiovascular diseases. Angelica gigas Nakai (AGN) has been reported to possess anti-obesity effects and higher amounts of coumarin compounds are present in AGN. However, the active compounds suppressing adipogenesis in AGN and mechanisms of action have not been investigated in adipose-derived stem cells (ASCs) isolated from visceral adipose tissue (VAT). Among four coumarin compounds of AGN, decursin (D) and decursinol angelate (DA) significantly inhibited adipocyte differentiation from ASCs. D and DA downregulated CCAAT/e

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Vassaux, Georges, Raymond Négrel, Gérard Ailhaud, and Danielle Gaillard. "Proliferation and differentiation of rat adipose precursor cells in chemically defined medium: Differential action of anti-adipogenic agents." Journal of Cellular Physiology 161, no. 2 (1994): 249–56. http://dx.doi.org/10.1002/jcp.1041610209.

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Kwon, Hyo-Shin, and Byeong-Churl Jang. "Anti-adipogenic Effect and Mechanism in 3T3-L1 Preadipocyte Differentiation by Salvianolic Acid B." Keimyung Medical Journal 41, no. 2 (2022): 67–75. http://dx.doi.org/10.46308/kmj.2022.00213.

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Salvianolic acid B (Sal B) is one of the most active hydrophilic compounds extracted from Salvia miltiorrhiza root. Previous in vitro and in vivo studies demonstrate the ability of Sal B to modulate adipocyte differentiation. However, the lipid-modulating effect and mechanism of Sal B in adipocytes remain controversial. Here we investigated the regulatory effect and mode of action of Sal B on lipid accumulation in 3T3-L1 preadipocyte differentiation. Lipid droplet (LD) accumulation and triglyceride (TG) content during 3T3-L1 preadipocyte differentiation were measured by Oil Red O staining and

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Aykul, Senem, Jordan Maust, Vijayalakshmi Thamilselvan, Monique Floer, and Erik Martinez-Hackert. "Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis." International Journal of Molecular Sciences 22, no. 16 (2021): 8472. http://dx.doi.org/10.3390/ijms22168472.

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Adipose tissues (AT) expand in response to energy surplus through adipocyte hypertrophy and hyperplasia. The latter, also known as adipogenesis, is a process by which multipotent precursors differentiate to form mature adipocytes. This process is directed by developmental cues that include members of the TGF-β family. Our goal here was to elucidate, using the 3T3-L1 adipogenesis model, how TGF-β family growth factors and inhibitors regulate adipocyte development. We show that ligands of the Activin and TGF-β families, several ligand traps, and the SMAD1/5/8 signaling inhibitor LDN-193189 profo

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Karadeniz, Fatih, Jung Hwan Oh, Hyun Jin Jo та ін. "Dracunculin Inhibits Adipogenesis in Human Bone Marrow-Derived Mesenchymal Stromal Cells by Activating AMPK and Wnt/β-Catenin Signaling". International Journal of Molecular Sciences 23, № 2 (2022): 653. http://dx.doi.org/10.3390/ijms23020653.

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Increased bone marrow adiposity is widely observed in patients with obesity and osteoporosis and reported to have deleterious effects on bone formation. Dracunculin (DCC) is a coumarin isolated from Artemisia spp. but, until now, has not been studied for its bioactive potential except antitrypanosomal activity. In this context, current study has reported the anti-adipogenic effect of DCC in human bone marrow-derived mesenchymal stromal cells (hBM-MSCs). DCC dose-dependently inhibited the lipid accumulation and expression of adipogenic transcription factors peroxisome proliferator-activated rec

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Yi, Sang Ah, Ki Hong Nam, Sil Kim, et al. "Vulpinic Acid Controls Stem Cell Fate toward Osteogenesis and Adipogenesis." Genes 11, no. 1 (2019): 18. http://dx.doi.org/10.3390/genes11010018.

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Vulpinic acid, a naturally occurring methyl ester of pulvinic acid, has been reported to exert anti-fungal, anti-cancer, and anti-oxidative effects. However, its metabolic action has not been implicated yet. Here, we show that vulpinic acid derived from a mushroom, Pulveroboletus ravenelii controls the cell fate of mesenchymal stem cells and preadipocytes by inducing the acetylation of histone H3 and α-tubulin, respectively. The treatment of 10T1/2 mesenchymal stem cells with vulpinic acid increased the expression of Wnt6, Wnt10a, and Wnt10b, which led to osteogenesis inhibiting the adipogenic

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Guan, Jian, and Deok Bae Park. "Effect of Ecklonia Cava on glucose consumption in rat skeletal muscle cells." Journal of Medicine and Life Science 9, no. 1 (2012): 44–48. http://dx.doi.org/10.22730/jmls.2012.9.1.44.

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Ecklonia cava is a kind of brown sea algae and its extract has known to be anti-adipogenic, anti-inflammatory, and so on. However, It less has been known about the action mechanism in regulating glucose metabolism in skeletal muscle cells. The present study investigated the effect of the ethanol extract of Ecklonia cava (E-EC) on glucose consumption and its related signaling properties in L6 rat skeletal muscle cells. E-EC slimulated glucose consumption as well as the translocation of glucose transporter 4 (Glut4) from cytosol to plasma membrane in L6 muscle cells. E-EC also stimulated Pl3 kin

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PARK, YU-KYOUNG, VICTOR SUKBONG HONG, TAE-YOON LEE, et al. "The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes." International Journal of Molecular Medicine 37, no. 1 (2015): 157–64. http://dx.doi.org/10.3892/ijmm.2015.2415.

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Lee, Soo-Young, Tae-Yang Kim, Ji-Yoon Hong, et al. "Anti-Obesity and Anti-Adipogenic Effects of Administration of Arginyl-Fructose-Enriched Jeju Barley (Hordeum vulgare L.) Extract in C57BL/6 Mice and in 3T3-L1 Preadipocytes Models." Molecules 27, no. 10 (2022): 3248. http://dx.doi.org/10.3390/molecules27103248.

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In our previous study, we reported that arginyl-fructose (AF), one of the Amadori rearrangement compounds (ARCs) produced by the heat processing of Korean ginseng can reduce carbohydrate absorption by inhibiting intestinal carbohydrate hydrolyzing enzymes in both in vitro and in vivo animal models. This reduced absorption of carbohydrate might be helpful to control body weight gain due to excessive carbohydrate consumption and support induced calorie restriction. However, the weight management effect, except for the effect due to anti-hyperglycemic action, along with the potential mechanism of

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Cheng, Hsin-Lin, Wei-Tang Chang, Jiun-Ling Lin, et al. "An Innovative Mei-Gin Formula Exerts Anti-Adipogenic and Anti-Obesity Effects in 3T3-L1 Adipocyte and High-Fat Diet-Induced Obese Rats." Foods 12, no. 5 (2023): 945. http://dx.doi.org/10.3390/foods12050945.

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Background: To investigate the potential anti-obesity properties of an innovative functional formula (called the Mei-Gin formula: MGF) consisting of bainiku-ekisu, Prunus mume (70% ethanol extract), black garlic (water extract), and Mesona procumbens Hemsl. (40% ethanol extract) for reducing lipid accumulation in 3T3-L1 adipocytes in vitro and obese rats in vivo. Material and Methods: The prevention and regression of high-fat diet (HFD)-induced obesity by the intervention of Japan Mei-Gin, MGF-3 and -7, and positive health supplement powder were investigated in male Wistar rats. The anti-obesi

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Li, L., L. Tam, L. Liu, T. Jin, and D. S. Ng. "Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway." Biochemistry and Cell Biology 89, no. 6 (2011): 515–21. http://dx.doi.org/10.1139/o11-048.

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Lysophosphatidic acid (LPA) is a bioactive phospholipid with a diverse range of biological activities including the modulation of adipogenesis. Treatment of 3T3-L1 cells and 3T3F44A cells with LPA inhibits adipogenesis and reduces expression of PPARγ through activation of RhoGTPase and its downstream Rho associated kinase (ROCK). The mechanism of suppression of PPARγ expression by Rho/ROCK is poorly understood. By treating the differentiating 3T3-L1 cells with various combinations of LPA and ROCK inhibitors, Y-27632 and fasudil, we observed that LPA treatment resulted in attenuation of adipoge

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Chao, Pei-Min, Hui-Ling Huang, Chun-Huei Liao, Shiau-Ting Huang, and Ching-jang Huang. "A high oxidised frying oil content diet is less adipogenic, but induces glucose intolerance in rodents." British Journal of Nutrition 98, no. 1 (2007): 63–71. http://dx.doi.org/10.1017/s000711450769000x.

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Oxidised frying oil (OFO) and fish oil have been shown to be peroxisome proliferator-activated receptor (PPAR)α activators and their ingestion results in pleotropic peroxisome proliferator responses in rats. To examine the effect of dietary OFO on adiposity, four groups of weanling Sprague–Dawley rats were fed isoenergetically with, respectively, a low fat basal diet containing 5 g/100 g of fresh soybean oil (LSB) or a high fat diet containing 20 g/100 g of fresh soybean oil (HSB), OFO (HO) or fish oil (HF). The tissue mass, cell size and lipid/DNA ratio in the retroperitoneal fat pad and seru

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Yadav, Anil Kumar, and Byeong-Churl Jang. "Inhibition of Lipid Accumulation and Cyclooxygenase-2 Expression in Differentiating 3T3-L1 Preadipocytes by Pazopanib, a Multikinase Inhibitor." International Journal of Molecular Sciences 22, no. 9 (2021): 4884. http://dx.doi.org/10.3390/ijms22094884.

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Pazopanib is a multikinase inhibitor with anti-tumor activity. As of now, the anti-obesity effect and mode of action of pazopanib are unknown. In this study, we investigated the effects of pazopanib on lipid accumulation, lipolysis, and expression of inflammatory cyclooxygenase (COX)-2 in differentiating and differentiated 3T3-L1 cells, a murine preadipocyte. Of note, pazopanib at 10 µM markedly decreased lipid accumulation and triglyceride (TG) content during 3T3-L1 preadipocyte differentiation with no cytotoxicity. Furthermore, pazopanib inhibited not only expression of CCAAT/enhancer-bindin

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Savova, Martina, Monika Todorova, Apostol Apostolov, Galina Yahubyan, and Milen Georgiev. "Betulinic acid counteracts the lipid accumulation in Caenorhabditis elegans by modulation of nhr-49 expression." Biomedicine & Pharmacotherapy 156 (October 12, 2022): 113862. https://doi.org/10.1016/j.biopha.2022.113862.

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Obesity is an ingrained health problem with а multifactorial origin and а long history, thereby innovations in the treatment strategies are of great importance. In the search of a remedy for excessive weight gain, we have directed our investigations to phytochemicals as valuable bioactive compounds. Betulinic acid (BA), among the other triterpenoids, is known for its anti-inflammatory and anti-neoplastic properties. In addition, a previous study of ours has demonstrated а potent anti-adipogenic effect of BA in human adipocytes. Therefore, we aimed here to further verify the anti-obesogenic eff

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Yang, Jinfeng, Wenxuan Jiang, Ju Hee Park, Eun Soo Seong, Yong Soo Kwon, and Myong Jo Kim. "Antioxidant and Pancreatic Lipase Inhibitory Activities of Panax japonicus (T. Nees) C.A. Meyer." Plants 14, no. 13 (2025): 2003. https://doi.org/10.3390/plants14132003.

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Obesity and its associated complications, including oxidative stress, pose significant global health challenges. Natural products offer a promising avenue for developing novel therapeutic strategies. In this study, we investigated the potential of Panax japonicus (T. Nees) C.A. Meyer, a traditional medicinal plant known for its antioxidant and anti-obesity properties. A methanol extract of Panax japonicus and its fractions were evaluated for their in vitro antioxidant activities (tested using DPPH and reducing power assays), pancreatic lipase (PL) inhibitory capacities, and underlying mechanis

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Lee, Eunyoung, Emily L. Miedzybrodzka, Xilin Zhang, et al. "Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms." International Journal of Molecular Sciences 20, no. 18 (2019): 4448. http://dx.doi.org/10.3390/ijms20184448.

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As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of the GIP hypersecretion seen in obesity might represent a novel therapeutic approach to the treatment of obesity. However, the mechanism of GIP hypersecretion remains largely unknown. In the present study, we investigated GIP secretion in two mouse models of obesity: High-fat diet-induced obese (DIO) mice and leptin-deficient Lepob/ob mice. In DIO mice, plasma GIP was increased along with an increase in GIP mRNA expression in the lower small intestine. Despite the robust alteration in the g

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Jin, Bo-Ram, Kyung-Sook Chung, Minho Lee, and Hyo-Jin An. "High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of Aster glehni via STAT3 Signaling Pathway." Biology 9, no. 2 (2020): 24. http://dx.doi.org/10.3390/biology9020024.

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Many epidemiological observational studies suggest that a high-fat diet (HFD) accelerates the risk of colorectal cancer (CRC). Inflammation can play a key role in the relationship between colon cancer and HFD. Although reported by several studies, controlled experimental studies have not explored this relationship. We established an HFD-fed colitis-associated colon cancer (CAC) mice model and evaluated the anti-tumorigenic effects of AG on HFD-propelled CAC along with its mechanism of action. Previously, we found that Aster glehni (AG) exerts chemopreventive effects on azoxymethane (AOM)/dextr

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Yadav, Rita, Munesh Mani, and Ramandeep Kaur. "A COMPREHENSIVE REVIEW ON ANTI-OBESITY POTENTIAL OF CYPERUS ROTUNDUS IN EXPERIMENTAL ANIMALS." YMER Digital 21, no. 07 (2022): 144–53. http://dx.doi.org/10.37896/ymer21.07/11.

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Worldwide, obesity and the illnesses it causes have become serious health issues, and obesity is today the fifth most common cause of death. According to research, there were 641 million obese adults worldwide in 2014. This review was based on detailing of obesity, BMI ranges, anti-obesity potential and signalling pathways of Cyperus rotundus. It covered extensive literature survey from the studies published in PubMed, Elsevier, Google Scholar etc. A member of the Cyperaceae family, Cyperus rotundus grows naturally in tropical and temperate climates and has long been used to heal mental and di

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Thalia, Odile Patrick, and Bizimana Rukundo T. "Plant-Derived Flavonoids as Natural Inhibitors of Adipogenesis and Glucose Dysregulation in Obese Diabetic Patients." RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES 5, no. 2 (2025): 36–41. https://doi.org/10.59298/rijses/2025/523641.

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The escalating global prevalence of obesity and type 2 diabetes mellitus (T2DM) necessitates innovative therapeutic approaches to address the intertwined pathologies of adipogenesis and glucose dysregulation. Flavonoids, a heterogeneous group of polyphenolic compounds ubiquitously present in plant-based foods, have emerged as dual-action agents capable of suppressing adipose tissue expansion and enhancing glycemic control. This review consolidates contemporary research on the molecular mechanisms underpinning the anti-adipogenic and glucose-lowering effects of flavonoids, including their modul

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Thalia, Odile Patrick, and Bizimana Rukundo T. "Plant-Derived Flavonoids as Natural Inhibitors of Adipogenesis and Glucose Dysregulation in Obese Diabetic Patients." RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES 5, no. 2 (2025): 36–41. https://doi.org/10.59298/rijses/2025/52364.

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The escalating global prevalence of obesity and type 2 diabetes mellitus (T2DM) necessitates innovative therapeutic approaches to address the intertwined pathologies of adipogenesis and glucose dysregulation. Flavonoids, a heterogeneous group of polyphenolic compounds ubiquitously present in plant-based foods, have emerged as dual-action agents capable of suppressing adipose tissue expansion and enhancing glycemic control. This review consolidates contemporary research on the molecular mechanisms underpinning the anti-adipogenic and glucose-lowering effects of flavonoids, including their modul

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Silvestro, Serena, Luigi Chiricosta, Agnese Gugliandolo, et al. "Extracellular Vesicles Derived from Human Gingival Mesenchymal Stem Cells: A Transcriptomic Analysis." Genes 11, no. 2 (2020): 118. http://dx.doi.org/10.3390/genes11020118.

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Human gingival mesenchymal stem cells (hGMSCs) have outstanding characteristics of proliferation and are able to differentiate into osteogenic, chondrogenic, adipogenic, and neurogenic cell lineages. The extracellular vesicles (EVs) secreted by hGMSCs contain proteins, lipids, mRNA and microRNA have emerged as important mediators of cell-to-cell communication. In this study, we analyzed the transcriptome of hGMSCs-derived EVs using Next Generation Sequencing (NGS). The functional evaluation of the transcriptome highlighted 26 structural protein classes and the presence of “non-coding RNAs”. Ou

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Grigorova, Natalia, Zhenya Ivanova, Ekaterina Vachkova, Valeria Petrova, and Toncho Penev. "DHA-Provoked Reduction in Adipogenesis and Glucose Uptake Could Be Mediated by Gps2 Upregulation in Immature 3T3-L1 Cells." International Journal of Molecular Sciences 24, no. 17 (2023): 13325. http://dx.doi.org/10.3390/ijms241713325.

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The signaling pathway of fatty acids in the context of obesity is an extensively explored topic, yet their primary mechanism of action remains incompletely understood. This study aims to examine the effect of docosahexaenoic acid (DHA) on some crucial aspects of adipogenesis in differentiating 3T3-L1 cells, using palmitic acid-treated (PA), standard differentiated, and undifferentiated adipocytes as controls. Employing 60 µM DHA or PA, 3T3-L1 preadipocytes were treated from the onset of adipogenesis, with negative and positive controls included. After eight days, we performed microscopic obser

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Mukherjee, Siddhartha, Noopur Raje, Chirayu Patel, et al. "Bortezomib Induces Proliferation of Mesenchymal Progenitor Cells and Promotes Differentiation towards Osteoblastic Lineage." Blood 108, no. 11 (2006): 88. http://dx.doi.org/10.1182/blood.v108.11.88.88.

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Abstract Bortezomib is a first-in-class proteasome inhibitor approved for the therapy of relapsed, refractory multiple myeloma (MM). Two large registration trials (SUMMIT and APEX) of bortezomib in MM revealed an increase in the serum levels of bone-specific alkaline phosphatase (b-ALP) and osteocalcin (ocn) in bortezomib-responsive patients, raising the prospect that bortezomib may influence the bone marrow (BM) microenvironment in association with its anti-myeloma effect,. However, the precise cellular target of bortezomib within the BM milieu remains unknown. We hypothesized that the observ

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Lacasa, Danièle, Soraya Taleb, Mayoura Keophiphath, Alexandra Miranville, and Karine Clement. "Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State in Preadipocytes." Endocrinology 148, no. 2 (2007): 868–77. http://dx.doi.org/10.1210/en.2006-0687.

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Obesity is considered a chronic low-grade inflammatory state. The white adipose tissue produces a variety of inflammation-related proteins whose expression is increased in obese subjects. The nonadipose cell fraction, which includes infiltrated macrophages, is a determinant source of inflammation-related molecules within the adipose tissue. Our working hypothesis is that macrophage infiltration affects fat expansion through a paracrine action on adipocyte differentiation. Human primary preadipocytes were then differentiated in the presence of conditioned media obtained from macrophages differe

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Park, Jae-Eun, та Ji-Sook Han. "(E)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone, a Major Homoisoflavonoid, Attenuates Free Fatty Acid-Induced Hepatic Steatosis by Activating AMPK and PPARα Pathways in HepG2 Cells". Nutrients 16, № 20 (2024): 3475. http://dx.doi.org/10.3390/nu16203475.

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Background: (E)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone (HMC), a homoisoflavonoid isolated from Portulaca oleracea, has significant anti-adipogenesis potential; it regulates adipogenic transcription factors. However, whether HMC improves hepatic steatosis in hepatocytes remains vague. This study investigated whether HMC ameliorates hepatic steatosis in free fatty acid-treated human hepatocellular carcinoma (HepG2) cells, and if so, its mechanism of action was analyzed. Methods: Hepatic steatosis was induced by a free fatty acid mixture in HepG2 cells. Thereafter, different HMC con

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Lutzow, Ylva Strandberg, Christian Gray та Ross Tellam. "15-Deoxy-Δ12,14-prostaglandin J2 induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells". Journal of Dairy Research 75, № 1 (2008): 55–63. http://dx.doi.org/10.1017/s0022029907003056.

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The roles of the pro-adipogenic ligands of the transcription factor Peroxisome Proliferator Activated Receptor gamma (PPARG) in regulating innate immune responses in bovine mammary epithelial cells (bMEC) were investigated using quantitative real-time PCR. The analyses revealed that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) enhanced the expression of Interleukin 8 (IL-8) and Chemokine (C-X-C motif) ligand 6 (CXCL6) in these cells in a dose-dependent manner. 15d-PGJ2 also induced the expression of transcripts encoding proteins involved in oxidative stress, including Ferritin heavy chain and S

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Silvestri, Elena, Rosalba Senese, Federica Cioffi, et al. "3,5-Diiodo-L-Thyronine Exerts Metabolically Favorable Effects on Visceral Adipose Tissue of Rats Receiving a High-Fat Diet." Nutrients 11, no. 2 (2019): 278. http://dx.doi.org/10.3390/nu11020278.

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When administered to rats receiving a high-fat diet (HFD), 3,5-diiodo-L-thyronine (3,5-T2) [at a dose of 25 μg/100 g body weight (BW)] is known to increase energy expenditure and to prevent HFD-induced adiposity. Here, we investigated which cellular and molecular processes in visceral white adipose tissue (VAT) contributed to the beneficial effect of 3,5-T2 over time (between 1 day and 4 weeks following administration). 3,5-T2 programmed the adipocyte for lipolysis by rapidly inducing hormone sensitive lipase (HSL) phosphorylation at the protein kinase A-responsive site Ser563, accompanied wit

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