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Journal articles on the topic 'Anti-amyloidogenic compounds'

Author: Grafiati

Published: 9 March 2023

Last updated: 19 July 2025

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1

Porzoor, Afsaneh, Benjamin Alford, Helmut Hügel, Danilla Grando, Joanne Caine, and Ian Macreadie. "Anti-Amyloidogenic Properties of Some Phenolic Compounds." Biomolecules 5, no. 2 (2015): 505–27. http://dx.doi.org/10.3390/biom5020505.

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2

Hirohata, Mie, Kenjiro Ono, and Masahito Yamada. "Non-Steroidal Anti-Inflammatory Drugs as Anti-Amyloidogenic Compounds." Current Pharmaceutical Design 14, no. 30 (2008): 3280–94. http://dx.doi.org/10.2174/138161208786404173.

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3

Skibiszewska and Jankowska. "Can Short Peptides Be Inhibitors of Serum Amyloid a Protein Aggregation?" Proceedings 22, no. 1 (2019): 38. http://dx.doi.org/10.3390/proceedings2019022038.

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4

Tan, Mario A., Mark Wilson D. Lagamayo, Grecebio Jonathan D. Alejandro, and Seong Soo A. An. "Anti-Amyloidogenic and Cyclooxygenase Inhibitory Activity of Guettarda speciosa." Molecules 24, no. 22 (2019): 4112. http://dx.doi.org/10.3390/molecules24224112.

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Guettarda speciosa is known in traditional folk medicine for treating cough, cold, sore throat, fever, wounds, epilepsy, and headaches. To discover the scientific pharmacological potential of G. speciosa, we explore its anti-inflammatory, cytotoxicity, and inhibition of amyloid-beta (Aβ) aggregation effects. Cyclooxygenase assay of the G. speciosa CHCl3 (GSC) extract and G. speciosa MeOH (GSM) extract are more selective to COX-1 inhibition with a 50% inhibitory concentration (IC50) of 3.56 μg/mL for the GSC extract and 4.98 μg/mL for the GSM extract. Neuroblastoma SH-SY5Y inhibition and thiofl

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5

Yeo, Ji-Yun, Seul Lee, Min Sung Ko, et al. "Anti-Amyloidogenic Effects of Metasequoia glyptostroboides Fruits and Its Active Constituents." Molecules 28, no. 3 (2023): 1017. http://dx.doi.org/10.3390/molecules28031017.

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Alzheimer’s disease (AD) is a serious neurodegenerative brain disease that interferes with daily life. The accumulation of beta-amyloid (Aβ), along with oxidative stress-inducing neurocellular apoptosis, has been considered one of the causes of AD. Thus, the purpose of this study is to find natural products that can reduce Aβ accumulation. The ethanol extract of Metasequoia glyptostroboides Hu & Cheng fruits (Cupressaceae) significantly reduced the aggregation of Aβ into oligomers and fibrils determined by Thioflavin T (ThT) assay. The solvent-partitioned ethyl acetate layer was further se

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Jaipuria, Aadya, Madison Castillo, James Boksanski, et al. "Extended Chalcones: Synthesis, In Vitro Analysis, and In Vivo Testing Against a Drosophila melanogaster Alzheimer’s Disease Model." Chemistry 6, no. 6 (2024): 1477–94. http://dx.doi.org/10.3390/chemistry6060089.

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Alzheimer’s Disease (AD) is the most common form of dementia in individuals over the age of 65. There is no known prevention for the progression of the disease, although the FDA recently approved two drugs for AD. The exact etiology of AD is still under debate; however, it is commonly associated with the aggregation of amyloid-beta (Aβ) plaques in the brain. Recently some extended chalcones were reported to be potential anti-amyloidogenic agents. In this study, a larger library of extended chalcone analogs were synthesized with modifications on both rings. These were tested using the Thioflavi

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7

Quiroz, Jose Paredes, Andi Zeng, Michelle Young, et al. "Homotaurine and Curcumin Analogues as Potential Anti-Amyloidogenic Agents." Chemistry 5, no. 1 (2023): 223–41. http://dx.doi.org/10.3390/chemistry5010018.

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Currently, there is neither a cure for Alzheimer’s disease (AD) nor a way to stop the progressive death of neuronal cells associated with this devastating aliment. To date, there are only medications that temporarily slow its progression, and do not interfere with its pathogenesis. One of the hallmarks of AD is the presence of amyloid-beta plaques derived from the metabolism of the amyloid precursor protein, via the cleavage by beta followed by gamma secretase. Homotaurine, a naturally occurring small molecule found in some seaweeds, and curcumin, a phenolic antioxidant found in Curcuma longa,

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8

Marvastizadeh, Narges, Bahareh Dabirmanesh, Reza H. Sajedi та Khosro Khajeh. "Anti-amyloidogenic effect of artemin on α-synuclein". Biological Chemistry 401, № 10 (2020): 1143–51. http://dx.doi.org/10.1515/hsz-2019-0446.

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Abstractα-Synuclein fibrillation is now regarded as a major pathogenic process in Parkinson’s disease and its proteinaceous deposits are also detected in other neurological disorders including Alzheimer's disease. Therefore anti-amyloidegenic compounds may delay or prevent the progression of synucleinopathies disease. Molecular chaperones are group of proteins which mediate correct folding of proteins by preventing unsuitable interactions which may lead to aggregation. The objective of this study was to investigate the anti-amyloidogenic effect of molecular chaperone artemin on α-synuclein. As

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9

Ziaunys, Mantas, and Vytautas Smirnovas. "Exploring Epigallocatechin-3-Gallate Autoxidation Products: Specific Incubation Times Required for Emergence of Anti-Amyloid Properties." Antioxidants 11, no. 10 (2022): 1887. http://dx.doi.org/10.3390/antiox11101887.

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Amyloidogenic protein/peptide aggregation into fibrillar aggregates is associated with multiple amyloidoses, including widespread neurodegenerative disorders. Despite years of research and a well-understood mechanism, there are still very few treatments available for the increasing number of amyloid-related disorders. In recent years, the search for potential anti-aggregation compounds has shifted toward naturally occurring molecules, with one of the most promising being epigallocatechin-3-gallate (EGCG). This polyphenolic compound was shown to inhibit the aggregation of several amyloidogenic

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10

Lakey-Beitia, Johant, Jagadeesh Kumar D., Muralidhar Hegde, and K. S. Rao. "Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis." International Journal of Molecular Sciences 20, no. 22 (2019): 5553. http://dx.doi.org/10.3390/ijms20225553.

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Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder that affects the aging population worldwide. Endogenous and exogenous factors are involved in triggering this complex and multifactorial disease, whose hallmark is Amyloid-β (Aβ), formed by cleavage of amyloid precursor protein by β- and γ-secretase. While there is no definitive cure for AD to date, many neuroprotective natural products, such as polyphenol and carotenoid compounds, have shown promising preventive activity, as well as helping in slowing down disease progression. In this article, we focus on the chemistr

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11

Jiaranaikulwanitch, Jutamas, Hataichanok Pandith, Sarin Tadtong, et al. "Novel Multifunctional Ascorbic Triazole Derivatives for Amyloidogenic Pathway Inhibition, Anti-Inflammation, and Neuroprotection." Molecules 26, no. 6 (2021): 1562. http://dx.doi.org/10.3390/molecules26061562.

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Alzheimer’s disease (AD) is a common neurodegenerative disorder. The number of patients with AD is projected to reach 152 million by 2050. Donepezil, rivastigmine, galantamine, and memantine are the only four drugs currently approved by the United States Food and Drug Administration for AD treatment. However, these drugs can only alleviate AD symptoms. Thus, this research focuses on the discovery of novel lead compounds that possess multitarget regulation of AD etiopathology relating to amyloid cascade. The ascorbic acid structure has been designated as a core functional domain due to several

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12

Florio, Daniele, Maria Cuomo, Ilaria Iacobucci, et al. "Modulation of Amyloidogenic Peptide Aggregation by Photoactivatable CO-Releasing Ruthenium(II) Complexes." Pharmaceuticals 13, no. 8 (2020): 171. http://dx.doi.org/10.3390/ph13080171.

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Three Ru(II)-based CO-releasing molecules featuring bidentate benzimidazole and terpyridine derivatives as ligands were investigated for their ability to modulate the aggregation process of the second helix of the C-terminal domain of nucleophosmin 1, namely nucleophosmin 1 (NPM1)264–277, a model amyloidogenic system, before and after irradiation at 365 nm. Thioflavin T (ThT) binding assays and UV/Vis absorption spectra indicate that binding of the compounds to the peptide inhibits its aggregation and that the inhibitory effect increases upon irradiation (half maximal effective concentration (

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13

Vasarri, Marzia, Matteo Ramazzotti, Bruno Tiribilli, et al. "The In Vitro Anti-amyloidogenic Activity of the Mediterranean Red Seaweed Halopithys Incurva." Pharmaceuticals 13, no. 8 (2020): 185. http://dx.doi.org/10.3390/ph13080185.

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Neurodegenerative diseases are generally characterized by the presence of neurotoxic amyloid aggregates underlying progressive neuronal death. Since ancient times, natural compounds have been used as curative agents for human health. Amyloid research is constantly looking for safe natural molecules capable of blocking toxic amyloid aggregates’ formation. From the marine environment, seaweeds are recognized as rich reservoirs of molecules with multiple bioactivities, including the anti-amyloidogenic activity. Here, hydroalcoholic extracts of two seasonal samples of the Mediterranean red seaweed

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14

Kleinrichert, Kody, and Bindhu Alappat. "Comparative Analysis of Antioxidant and Anti-Amyloidogenic Properties of Various Polyphenol Rich Phytoceutical Extracts." Antioxidants 8, no. 1 (2019): 13. http://dx.doi.org/10.3390/antiox8010013.

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Though the pathogenesis of Alzheimer’s Disease (AD) is not completely elucidated, it is generally accepted that the aggregation of toxic amyloid-β (Aβ) protein fibrils plays a major role in the disease’s onset and progression. Various phytoceutical compounds have been shown to attenuate Aβ toxicity and disrupt its aggregation, including various types of polyphenolic compounds. These polyphenolic compounds have also been found to demonstrate potent antioxidant activity, which may contribute to their anti-amyloidogenic properties. This study compares three plants, traditionally used for numerous

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15

Ciaramelli, Carlotta, Alessandro Palmioli, Ada De Luigi, et al. "NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts." Food Chemistry 252 (June 2018): 171–80. http://dx.doi.org/10.1016/j.foodchem.2018.01.075.

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16

Hengge, Regine. "Targeting Bacterial Biofilms by the Green Tea Polyphenol EGCG." Molecules 24, no. 13 (2019): 2403. http://dx.doi.org/10.3390/molecules24132403.

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Bacterial biofilms are multicellular aggregates in which cells are embedded in an extracellular matrix of self-produced biopolymers. Being refractory to antibiotic treatment and host immune systems, biofilms are involved in most chronic infections, and anti-biofilm agents are being searched for urgently. Epigallocatechin-3-gallate (EGCG) was recently shown to act against biofilms by strongly interfering with the assembly of amyloid fibres and the production of phosphoethanolamin-modified cellulose fibrils. Mechanistically, this includes a direct inhibition of the fibre assembly, but also trigg

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17

Paudel, Pradeep, Ritu Prajapati, Hyun Jung Lim та ін. "Anti-Glycation, Anti-β-Amyloid Aggregation, and Antioxidant Effect of Cassia Seed-Derived Secondary Metabolites". Journal of Food Biochemistry 2023 (21 жовтня 2023): 1–12. http://dx.doi.org/10.1155/2023/8868031.

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Aggregation and non-enzymatic glycation of amyloidogenic peptides, amyloid-beta (Aβ), and insulin are key features of neuropathology. In this study, we evaluate the anti-glycation effect of Cassia seed-derived secondary metabolites on human insulin and bovine serum albumin, as well as their anti-Aβ aggregation and antioxidant effects using in vitro spectrofluorometric method, thioflavin T fluorescence, and peroxynitrite (ONOO‒) scavenging assay. Furthermore, molecular docking simulation was performed to investigate the binding characteristics of test compounds and Aβ42 peptide. Among 38 compou

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18

Musteikyte, Greta, Mantas Ziaunys, and Vytautas Smirnovas. "Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils." PeerJ 8 (August 14, 2020): e9719. http://dx.doi.org/10.7717/peerj.9719.

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Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloid compounds, no effective cure or treatment is currently available. Methylene blue (MB), a phenothiazine dye, has been shown to modulate the aggregation of multiple amyloidogenic proteins. In this work we show its ability to inhibit both the spontaneous amyloid aggregation of SOD1

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19

Galdeano, Carles, Elisabet Viayna, Irene Sola, et al. "Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases." Journal of Medicinal Chemistry 55, no. 2 (2012): 661–69. http://dx.doi.org/10.1021/jm200840c.

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20

Nisha, Chaluveelaveedu Murleedharan, Ashwini Kumar, Prateek Nair та ін. "Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase". Advances in Bioinformatics 2016 (10 квітня 2016): 1–6. http://dx.doi.org/10.1155/2016/9258578.

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Amyloidogenic pathway in Alzheimer’s disease (AD) involves breakdown of APP by β-secretase followed by γ-secretase and results in formation of amyloid beta plaque. β-secretase has been a promising target for developing novel anti-Alzheimer drugs. To test different molecules for this purpose, test ligands like acylguanidine 7a, rosiglitazone, pioglitazone, and tartaric acid were docked against our target protein β-secretase enzyme retrieved from Protein Data Bank, considering MK-8931 (phase III trial, Merck) as the positive control. Docking revealed that, with respect to their free binding ener

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21

Daowtak, Krai, Wilart Pompimon, Milena Salerno, and Chatchanok Udomtanakunchai. "Decelerate amyloid fibrillation by the alkaloids extracted from Stephania venosa." Journal of Associated Medical Sciences 56, no. 3 (2023): 52–59. http://dx.doi.org/10.12982/jams.2023.053.

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Background: Naturally occurring phytochemical compounds have received considerable attention as alternative candidates for anti-amyloidogenic agents. Objectives: This study, utilizing human insulin and amyloid-β peptide as an in vitro model, determined the anti-amyloid effects of alkaloids extracted derived from Stephania venosa. Materials and methods: Alkaloids extracts including crebanine, O-methylbulbocapnine, tetrahydropalmatine and N-methyltetrahydropalmatine were used. The Inhibition of amyloid protein aggregation was studied by fluorescence spectroscopy. Results: Most alkaloids, except

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22

Ramya, S., T. Loganathan, M. Chandran, et al. "Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil." Journal of Drug Delivery and Therapeutics 12, no. 2-S (2022): 110–18. http://dx.doi.org/10.22270/jddt.v12i2-s.5280.

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Seeds of cumin (Cuminum cyminum L.) are widely used as a spice for their distinctive aroma. C. cyminum have been used in traditional medicine to treat a variety of diseases. Literature presents ample evidence for biomedical activities of cumin which is attributed to its bioactive secondary metabolites - terpenes, phenols, and flavonoids. Besides, health effects of cumin seeds have been experimentally validated through phytochemical analysis depicting the presence of a wide array of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinone, flavonoid, glycoside, protein, r

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23

Ramya, S., T. Loganathan, M. Chandran, et al. "Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil." Journal of Drug Delivery and Therapeutics 12, no. 2-S (2022): 110–18. http://dx.doi.org/10.22270/jddt.v12i2-s.5280.

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Seeds of cumin (Cuminum cyminum L.) are widely used as a spice for their distinctive aroma. C. cyminum have been used in traditional medicine to treat a variety of diseases. Literature presents ample evidence for biomedical activities of cumin which is attributed to its bioactive secondary metabolites - terpenes, phenols, and flavonoids. Besides, health effects of cumin seeds have been experimentally validated through phytochemical analysis depicting the presence of a wide array of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinone, flavonoid, glycoside, protein, r

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24

Alattiya, Reem Halim, Farah Khalid Tarish, Lina Loai Hashim, and Saad Abdulrahman Hussain. "The Role of Polyphenols in the Treatment of Alzheimer's Disease: Narrative Review." Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) 1 (October 13, 2021): 53–61. http://dx.doi.org/10.54133/ajms.v1i.31.

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Many epidemiological studies have suggested that consuming a diet rich in polyphenols can help prevent Alzheimer's disease (AD). Based on well-known in vitro and in vivo models of cerebral Aβ amyloidosis, we examined the data on the effects of various natural polyphenols on the aggregation of amyloid-protein (Aβ). These polyphenols effectively prevent oligomerization and fibril formation of Aβ through differential binding patterns, lowering Aβ oligomer-induced synaptic and neuronal toxicity, according to in vitro investigations. Furthermore, in a transgenic mouse model fed orally with such pol

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Poliseno, Viviana, Sílvia Chaves, Leonardo Brunetti, et al. "Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents." Biomolecules 11, no. 1 (2021): 111. http://dx.doi.org/10.3390/biom11010111.

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Alzheimer’s disease (AD) is generally recognized as a multifactorial neurodegenerative pathology with an increasing impact on society. Tenuazonic acid (TA) is a natural compound that was recently identified as a potential multitarget ligand with anti-cholinesterase, anti-amyloidogenic and antioxidant activities. Using its structure as a chemical scaffold, we synthesized and evaluated new derivatives (1–5), including tenuazonic-donepezil (TA-DNP) hybrids (4 and 5) due to the clinical importance of the anti-AD drug donepezil. These novel compounds all achieved activity in the micromolar range to

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Ramya, S., T. Loganathan, M. Chandran, et al. "ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications." Journal of Drug Delivery and Therapeutics 12, no. 2-S (2022): 127–41. http://dx.doi.org/10.22270/jddt.v12i2-s.5286.

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Cuminum cyminum L (Family: Apiaceae) is a small multipurpose herb. Seeds of cumin are widely used as a spice for its distinctive aroma, and more commonly in various indigenous traditional systems of medicine. Access through web literature provides ample evidence for biomedical activities of Cuminum cyminum seeds (CCS). CCS has been used in traditional medicine to treat variety of diseases, including hypolipidemia, cancer, and diabetes. Biomedical properties of CCS is attributed to its phytochemical class of compounds viz., terpenes, phenols and flavonoids. Health effects of CCS have been exper

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27

Ramya, S., T. Loganathan, M. Chandran, et al. "ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications." Journal of Drug Delivery and Therapeutics 12, no. 2-S (2022): 127–41. http://dx.doi.org/10.22270/jddt.v12i2-s.5286.

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Abstract:

Cuminum cyminum L (Family: Apiaceae) is a small multipurpose herb. Seeds of cumin are widely used as a spice for its distinctive aroma, and more commonly in various indigenous traditional systems of medicine. Access through web literature provides ample evidence for biomedical activities of Cuminum cyminum seeds (CCS). CCS has been used in traditional medicine to treat variety of diseases, including hypolipidemia, cancer, and diabetes. Biomedical properties of CCS is attributed to its phytochemical class of compounds viz., terpenes, phenols and flavonoids. Health effects of CCS have been exper

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28

Ramya, S., T. Loganathan, M. Chandran, et al. "ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications." Journal of Drug Delivery and Therapeutics 12, no. 2-S (2022): 127–41. http://dx.doi.org/10.22270/jddt.v12i2-s.5286.

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Abstract:

Cuminum cyminum L (Family: Apiaceae) is a small multipurpose herb. Seeds of cumin are widely used as a spice for its distinctive aroma, and more commonly in various indigenous traditional systems of medicine. Access through web literature provides ample evidence for biomedical activities of Cuminum cyminum seeds (CCS). CCS has been used in traditional medicine to treat variety of diseases, including hypolipidemia, cancer, and diabetes. Biomedical properties of CCS is attributed to its phytochemical class of compounds viz., terpenes, phenols and flavonoids. Health effects of CCS have been exper

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29

Hosseinkhani, Ayda, Ali Sahragard, Aida Namdari, and Mohammad M. Zarshenas. "Botanical Sources for Alzheimer’s: A Review on Reports From Traditional Persian Medicine." American Journal of Alzheimer's Disease & Other Dementiasr 32, no. 7 (2017): 429–37. http://dx.doi.org/10.1177/1533317517717013.

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Herbal medicines for the treatment of Alzheimer’s disease (AD) have attracted considerable attention nowadays. Alzheimer’s disease is described in traditional Persian medicine (TPM) by the term Nesyān. In this study, 5 main medicinal medieval Persian manuscripts were reviewed to filter plants reported for the treatment of Nesyān. Databases were searched for related possible mechanisms of action of these medicinal plants. Each herb was searched for along with these keywords: “acetyl and butyryl cholinesterase inhibition,” “antioxidant,” “anti-inflammatory,” and “anti-amyloidogenic.” In Total, 4

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Li, Hongyun, Genevieve Evin, Andrew F. Hill, Ya Hui Hung, Ashley I. Bush, and Brett Garner. "Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues." Clinical Science 122, no. 9 (2012): 409–20. http://dx.doi.org/10.1042/cs20110257.

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Inhibition of GSL (glycosphingolipid) synthesis reduces Aβ (amyloid β-peptide) production in vitro. Previous studies indicate that GCS (glucosylceramide synthase) inhibitors modulate phosphorylation of ERK1/2 (extracellular-signal-regulated kinase 1/2) and that the ERK pathway may regulate some aspects of Aβ production. It is not clear whether there is a causative relationship linking GSL synthesis inhibition, ERK phosphorylation and Aβ production. In the present study, we treated CHO cells (Chinese-hamster ovary cells) and SH-SY5Y neuroblastoma cells, that both constitutively express human wi

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Quezada, Elías, Fernanda Rodríguez-Enríquez, Reyes Laguna, et al. "Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders." Molecules 26, no. 15 (2021): 4550. http://dx.doi.org/10.3390/molecules26154550.

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Neurodegenerative diseases have a complex nature which highlights the need for multitarget ligands to address the complementary pathways involved in these diseases. Over the last decade, many innovative curcumin-based compounds have been designed and synthesized, searching for new derivatives having anti-amyloidogenic, inhibitory of tau formation, as well as anti-neuroinflammation, antioxidative, and AChE inhibitory activities. Regarding our experience studying 3-substituted coumarins with interesting properties for neurodegenerative diseases, our aim was to synthesize a new series of curcumin

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Kashyap, Priya, Vivekanandan Kalaiselvan, Robin Kumar, and Suresh Kumar. "Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer’s Disease." Molecules 25, no. 7 (2020): 1609. http://dx.doi.org/10.3390/molecules25071609.

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Alzheimer’s disease (AD) is a multifactorial disorder characterized by exponential loss of memory and cognitive deficit involving several disease modifying targets (amyloid beta, beta-secretase, monoaminoxidase-B, and cholinesterase). The present study explores multi-target directed ligand approach using secondary metabolite reserpine (RES) and ajmalicine (AJM) obtained from Rauwolfia serpentina roots. Novel LCMS and HPLC methods were developed for identification and quantification of reserpine and ajmalicine. In vitro enzyme inhibition assays were performed to evaluate anti-cholinesterase, β-

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Martinez Pomier, Karla, Rashik Ahmed, and Giuseppe Melacini. "Catechins as Tools to Understand the Molecular Basis of Neurodegeneration." Molecules 25, no. 16 (2020): 3571. http://dx.doi.org/10.3390/molecules25163571.

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Protein misfolding as well as the subsequent self-association and deposition of amyloid aggregates is implicated in the progression of several neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Modulators of amyloidogenic aggregation serve as essential tools to dissect the underlying molecular mechanisms and may offer insight on potential therapeutic solutions. These modulators include green tea catechins, which are potent inhibitors of amyloid aggregation. Although catechins often exhibit poor pharmacokinetic properties and bioavailability, they are still essential to

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Sahu, Columbus, and Ritesh Jain. "Neuroprotective Effects of Terminalia catappa L.: A Promising Natural Remedy for Alzheimer's Disease." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1138–41. https://doi.org/10.35629/4494-100111381141.

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Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by cognitive impairment, memory deterioration, and behavioral changes. Despite advancements in understanding AD pathophysiology, existing treatments provide only symptomatic relief without halting disease progression. Natural compounds, such as those found in Terminalia catappa L. (tropical almond), have garnered attention for their neuroprotective potential. Terminalia catappa is abundant in bioactive molecules, including flavonoids, tannins, and triterpenoids, which exhibit antioxidant, antiinflammatory, and anti-am

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Hannan, Md Abdul, Raju Dash, Md Nazmul Haque, et al. "Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances." Marine Drugs 18, no. 7 (2020): 347. http://dx.doi.org/10.3390/md18070347.

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated comp

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Afzal, Sheryar. "Deciphering curcumin and piperine's anti-amyloidogenic capabilities using an in silicomethod: A look at ligand-target complex formation." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 24, no. 2 (2025): 256–72. https://doi.org/10.37360/blacpma.25.24.2.19.

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Amyloid-β (Aβ) peptides play pivotal role in the pathogenesis of Alzheimer Disease (AD) and exert toxic effects on neurons. Current treatment options available to AD patients, such as AChE inhibitors, only provide symptomatic relief. Dietary phytochemicalsare currently being used as adjuvant therapy to expedite their therapeutic efficacy. This study was designed to investigate potential bioactive compounds of curcumin and piperine as anti-amyloidogenic agents. Molecular docking was applied to conduct screening process in silico to predict the most probable conformation of curcumin and piperine

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Rodríguez-Blázquez, Sandra, Laura Pedrera-Cajas, Esther Gómez-Mejía, et al. "The Potential of Plum Seed Residue: Unraveling the Effect of Processing on Phytochemical Composition and Bioactive Properties." International Journal of Molecular Sciences 25, no. 2 (2024): 1236. http://dx.doi.org/10.3390/ijms25021236.

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Bioactive compounds extracted from plum seeds were identified and quantified, aiming to establish how the brandy manufacturing process affects the properties and possible cascade valorization of seed residues. Extraction with n-hexane using Soxhlet has provided oils rich in unsaturated fatty acids (92.24–92.51%), mainly oleic acid (72–75.56%), which is characterized by its heart-healthy properties. The fat extracts also contain tocopherols with antioxidant and anti-inflammatory properties. All the ethanol–water extracts of the defatted seeds contain neochlorogenic acid (90–368 µg·g−1), chlorog

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Abdul Manap, Aimi Syamima, Priya Madhavan, Shantini Vijayabalan, Adeline Chia та Koji Fukui. "Explicating anti-amyloidogenic role of curcumin and piperine via amyloid beta (Aβ) explicit pathway: recovery and reversal paradigm effects". PeerJ 8 (30 вересня 2020): e10003. http://dx.doi.org/10.7717/peerj.10003.

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Previously, we reported the synergistic effects of curcumin and piperine in cell cultures as potential anti-cholinesterase and anti-amyloidogenic agents. Due to limited findings on the enrolment of these compounds on epigenetic events in AD, we aimed at elucidating the expression profiles of Aβ42-induced SH-SY5Y cells using microarray profiling. In this study, an optimized concentration of 35 µM of curcumin and piperine in combination was used to treat Aβ42 fibril and high-throughput microarray profiling was performed on the extracted RNA. This was then compared to curcumin and piperine used s

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Caruana, Mario, Angelique Camilleri, Maria Ylenia Farrugia, et al. "Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides." Molecules 26, no. 5 (2021): 1444. http://dx.doi.org/10.3390/molecules26051444.

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The identification of compounds which protect the double-membrane of mitochondrial organelles from disruption by toxic confomers of amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here, we exploited an extract from the marine brown seaweed Padina pavonica (PPE) as a vital source of natural bioactive compounds to protect mitochondrial membranes against insult by oligomeric aggregates of the amyloidogenic proteins amyloid-β (Aβ), α-synuclein (α-syn) and tau, which are currently considered to be major targets for drug discovery in Alzheimer’s disease

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Cichon, Natalia, Weronika Grabowska, Leslaw Gorniak, et al. "Mechanistic and Therapeutic Insights into Flavonoid-Based Inhibition of Acetylcholinesterase: Implications for Neurodegenerative Diseases." Nutrients 17, no. 1 (2024): 78. https://doi.org/10.3390/nu17010078.

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Flavonoids are naturally occurring polyphenolic compounds known for their extensive range of biological activities. This review focuses on the inhibitory effects of flavonoids on acetylcholinesterase (AChE) and their potential as therapeutic agents for cognitive dysfunction. AChE, a serine hydrolase that plays a crucial role in cholinergic neurotransmission, is a key target in the treatment of cognitive impairments due to its function in acetylcholine hydrolysis. Natural polyphenolic compounds, particularly flavonoids, have demonstrated significant inhibition of AChE, positioning them as promi

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Nazarova, Anastasia, Igor Shiabiev, Ksenia Shibaeva, et al. "Thiacalixarene Carboxylic Acid Derivatives as Inhibitors of Lysozyme Fibrillation." International Journal of Molecular Sciences 25, no. 9 (2024): 4721. http://dx.doi.org/10.3390/ijms25094721.

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Amyloid fibroproliferation leads to organ damage and is associated with a number of neurodegenerative diseases affecting populations worldwide. There are several ways to protect against fibril formation, including inhibition. A variety of organic compounds based on molecular recognition of amino acids within the protein have been proposed for the design of such inhibitors. However, the role of macrocyclic compounds, i.e., thiacalix[4]arenes, in inhibiting fibrillation is still almost unknown. In the present work, the use of water-soluble thiacalix[4]arene derivatives for the inhibition of hen

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Mikalauskaite, Kamile, Mantas Ziaunys, and Vytautas Smirnovas. "Lysozyme Amyloid Fibril Structural Variability Dependence on Initial Protein Folding State." International Journal of Molecular Sciences 23, no. 10 (2022): 5421. http://dx.doi.org/10.3390/ijms23105421.

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Amyloid fibril formation is associated with several amyloidoses, including neurodegenerative Alzheimer’s or Parkinson’s diseases. The process of such fibrillar structure formation is still not fully understood, with new mechanistic insights appearing on a regular basis. This, in turn, has limited the development of potential anti-amyloid compounds, with only a handful of effective cures or treatment modalities available. One of the multiple amyloid aggregation factors that requires further examination is the ability of proteins to form multiple, structurally distinct aggregates, based on the e

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Akter, Sharmin, Takayuki Tohge, Sahithya Hulimane Ananda, Masahiro Kuragano, Kiyotaka Tokuraku, and Koji Uwai. "Anti-Amyloid Aggregation Effects of Gobaishi (Galla chinensis) and Its Active Constituents." Molecules 30, no. 13 (2025): 2720. https://doi.org/10.3390/molecules30132720.

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Alzheimer′s disease (AD) is a chronic neurodegenerative disorder that leads to memory loss and changes in mental and behavioral functions in elderly individuals. A major pathological feature of AD is the aggregation of amyloid-beta (Aβ) peptides, along with oxidative stress, inducing neurocellular apoptosis in the brain. Gobaishi (Galla chinensis), a traditional herbal medicine, has gained considerable attention for its constituents and potent therapeutic properties, particularly its strong inhibitory activity against Aβ fibril formation. In this study, we investigated the anti-Aβ aggregation

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Corti, Roberta, Alysia Cox, Valeria Cassina, et al. "The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation." International Journal of Molecular Sciences 21, no. 3 (2020): 1066. http://dx.doi.org/10.3390/ijms21031066.

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The deposition of amyloid-β (Aβ) plaques in the brain is a significant pathological signature of Alzheimer’s disease, correlating with synaptic dysfunction and neurodegeneration. Several compounds, peptides, or drugs have been designed to redirect or stop Aβ aggregation. Among them, the trideca-peptide CWG-LRKLRKRLLR (mApoE), which is derived from the receptor binding sequence of apolipoprotein E, is effectively able to inhibit Aβ aggregation and to promote fibril disaggregation. Taking advantage of Atomic Force Microscopy (AFM) imaging and fluorescence techniques, we investigate if the cluste

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Coimbra, Judite R. M., Salete J. Baptista, Teresa C. P. Dinis, et al. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors." Biomolecules 10, no. 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535.

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The treatment options for a patient diagnosed with Alzheimer’s disease (AD) are currently limited. The cerebral accumulation of amyloid-β (Aβ) is a critical molecular event in the pathogenesis of AD. When the amyloidogenic β-secretase (BACE1) is inhibited, the production of Aβ peptide is reduced. Henceforth, the main goal of this study is the discovery of new small bioactive molecules that potentially reach the brain and inhibit BACE1. The work was conducted by a customized molecular modelling protocol, including pharmacophore-based and molecular docking-based virtual screening (VS). Structure

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Gijsen, Harrie J. M., and Marc Mercken. "-Secretase Modulators: Can We Combine Potency with Safety?" International Journal of Alzheimer's Disease 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/295207.

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-Secretase modulation has been proposed as a potential disease modifying anti-Alzheimer’s approach. -Secretase modulators (GSMs) cause a product shift from the longer amyloid-beta (Aβ) peptide isoforms to shorter, more soluble, and less amyloidogenic isoforms, without inhibiting APP or Notch proteolytic processing. As such, modulating -secretase may avoid some of the adverse effects observed with -secretase inhibitors. Since the termination of the GSM tarenfurbil in 2008 due to negative phase III trial results, a considerable progress has been made towards more potent and better brain penetrab

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Dhahri, Manel, Mawadda Alghrably, Hamdoon A. Mohammed, et al. "Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases." Pharmaceutics 14, no. 1 (2021): 1. http://dx.doi.org/10.3390/pharmaceutics14010001.

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Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of dementia was US$818 billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. While advances have been made to understand different neurodegenerative disease mechanisms, effective therapeutic strategies do not generally exist. Several drugs have been proposed in the last two decades for the treatment of different types of neurodegenerative diseases, with little therapeutic benefit, and often with severe adverse and side effe

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Youn, Kumju, and Mira Jun. "Determination of Potential Lead Compound from Magnolia officinalis for Alzheimer’s Disease through Pharmacokinetic Prediction, Molecular Docking, Dynamic Simulation, and Experimental Validation." International Journal of Molecular Sciences 25, no. 19 (2024): 10507. http://dx.doi.org/10.3390/ijms251910507.

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Amyloid β protein (Aβ) deposition has been implicated as the molecular driver of Alzheimer’s disease (AD) progression. The modulation of the formation of abnormal aggregates and their post-translational modification is strongly suggested as the most effective approach to anti-AD. Beta-site APP-cleaving enzyme 1 (BACE1) acts upstream in amyloidogenic processing to generate Aβ, which rapidly aggregates alone or in combination with acetylcholinesterase (AChE) to form fibrils. Accumulated Aβ promotes BACE1 activation via glycogen synthase kinase-3β (GSK-3β) and is post-translationally modified by

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Nandkishor, Chavan Dr. Raghunath Wadulkar Dr. Kranti Satpute Sushil Bhalerao Sanika Futane. "Towards A New Frontier in Alzheimer's Disease Treatment: Promising Medicinal Plants and Bioactive Compounds." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 807–23. https://doi.org/10.5281/zenodo.15597645.

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A neurological disorder that deteriorates with age, Alzheimer's disease (AD) is typified by significant cognitive impairment, memory loss, and aberrant behaviour. There is currently no cure, despite much investigation, and the only relief offered by existing medications is symptomatic. The creation of efficient therapeutic approaches is essential given the rising prevalence of AD worldwide. Recent advances in our knowledge of the pathophysiology of AD have led to the discovery of novel therapy targets, increasing the likelihood of more direct involvement in the disease process. Clinical resear

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Shohag, Sheikh, Shomaya Akhter, Al Amin, et al. "Insights into the Promising Prospect of Medicinal Plants for the Therapeutic Approaches of Alzheimer's Disease." Middle East Research Journal of Medical Sciences 5, no. 02 (2025): 147–77. https://doi.org/10.36348/merjms.2025.v05i02.006.

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Dementia and cognitive decline are associated with Alzheimer's disease (AD), a chronic, progressive neurological disorder that mostly affects the elderly. AD is caused by extracellular Amyloid-beta 42 plaques, intracellular hyperphosphorylated Tau tangles, mitochondrial dysfunction, and genetic anomalies. The brain's cells die from faulty signal transduction caused by amyloid and tau tangles. This creates cognitive, behavioral, and mental issues. Shrinking central nervous system direct treatment exists for AD. Researchers have been screening a library of micro-inhibitor compounds or bioactive

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