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Journal articles on the topic 'Anti-anginal/anti ischemic'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Lardizabal, Joel A., and Prakash C. Deedwania. "The Anti-Ischemic and Anti-Anginal Properties of Statins." Current Atherosclerosis Reports 13, no. 1 (2010): 43–50. http://dx.doi.org/10.1007/s11883-010-0147-y.

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Wimmer, Neil J., and Peter H. Stone. "Anti-Anginal and Anti-Ischemic Effects of Late Sodium Current Inhibition." Cardiovascular Drugs and Therapy 27, no. 1 (2012): 69–77. http://dx.doi.org/10.1007/s10557-012-6431-z.

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3

Малыгина, V. Malygina, Сергунина, et al. "Evaluation of effect of the coronater drug on the indices of deformation of the left ventricular myocardium in patients with chd." Journal of New Medical Technologies. eJournal 8, no. 1 (2014): 0. http://dx.doi.org/10.12737/7364.

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Currently, the methods of early diagnosis and treatment of stable angina are of interest to researchers. One of the methods of diagnosis is echocardiography using a two-dimensional speckle tracking. Technology speckle tracking allows to evaluate systolic and diastolic heart function in various cardiovascular diseases, including coronary heart disease (CHD). By means of this program all types of myocardial deformation: radial, circular, longitudinal, the rate of deformation and rotation of the myocardium can be evaluated. The clinical studies have shown that changes in the indices of deformatio

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Abbas, Eslam, Ahmed Mahdy, and Shady Mansy. "Relentless Angina of a Scarred Heart." Cardiology and Cardiovascular Research 8, no. 4 (2024): 92–95. https://doi.org/10.11648/j.ccr.20240804.11.

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Refractory anginal pain affects nearly 5-10% of stable coronary artery disease patients, and maximizing the anti-ischemic medical therapy is the standard first-line treatment. The presence of a scarred myocardial territory of the epicardial coronary chronic total occlusion (CTO) limits the implementation of other modalities, such as angioplasty and surgical bypass. Accordingly, this subset of patients, who show poor response to medical treatment with the absence of considerable reversible ischemia, bears an additional burden of persistent angina besides the structural and functional complicati

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A., H. M. Nazmul Hasan, Jahid Hasan Sk., Anzam Ul Islam Md., Awal Trina Afsana, Nahar Deepa Kanij, and Asaduzzaman Md. "Pattern of Pharmacotherapy of Patients Having Ischemic Heart Disease at a Specialized Hospital in Dhaka, Bangladesh: A Survey Based Study on Patients Discharged from Hospital." British Journal of Medicine & Medical Research 22, no. 2 (2017): 1–9. https://doi.org/10.9734/BJMMR/2017/34107.

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<strong>Aims: </strong>Study on pharmacotherapeutic pattern on cardiovascular patients is rarely done. Patient’s demography, drug usage and its clinical outcome are the basis for the assessment of cardiac treatment. The aim of this study to analyze the demography of patients of ischemic heart disease along with drug usage and current trends of practice in Bangladesh. <strong>Methods: </strong>This study was carried out over a period of two months at different units of NICVD, situated at Dhaka, Bangladesh. A structured questionnaire was prepared to collect necessary data from patients. Descript

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Kobrin, Isaac, Gabriele Bieska, Vincent Charlon, Elisabet Lindberg, and Robert Pordy. "Anti-Anginal and Anti-Ischemic Effects of Mibefradil, a New T-Type Calcium Channel Antagonist." Cardiology 89, no. 1 (1998): 23–32. http://dx.doi.org/10.1159/000047276.

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Zadionchenko, V. S., G. G. Shehyan, A. A. Yalymov, and S. I. Varentsov. "The use of ranolazine in the treatment of coronary heart disease." CardioSomatics 5, no. 3-4 (2014): 48–53. http://dx.doi.org/10.26442/cs45130.

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The paper presents the study of a new anti-anginal drug - sodium channel inhibitor ranolazine. Considered antianginal, anti-ischemic effect of the drug. Described reduction in angina attacks, increased exercise tolerance and quality of life of patients with stable angina during treatment with ranolazine. Discusses indications, contraindications, side effects, as well as the major clinical trials of the drug ranolazine in patients with coronary heart disease.

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Tardif, Jean-Claude. "Safety and Efficacy of Ivabradine in the Management of Stable Angina Pectoris." Clinical Medicine. Therapeutics 1 (January 2009): CMT.S1086. http://dx.doi.org/10.4137/cmt.s1086.

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The first selective If current inhibitor, ivabradine, lowers heart rate (HR) at rest and during exercise with no vasomotor, negative inotropic, or negative lusitropic effects. Given that elevated resting HR is a key factor in the onset of myocardial ischemia and a strong independent predictor of cardiovascular outcomes, ivabradine provides new therapeutic prospects in coronary artery disease (CAD). Its selective HR-lowering action has proven anti-ischemic and anti-anginal efficacy, and ivabradine is currently indicated for the symptomatic treatment of stable angina pectoris. Ivabradine can als

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S., Madhumitha V. Karan*. "Novel Drugs Approach in Treatment of Angina." International Journal of Scientific Research and Technology 2, no. 3 (2025): 477–82. https://doi.org/10.5281/zenodo.15085105.

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Angina Pectoris is a common symptom of ischemic heart disease. In 1772 according to William Heberden Angina is characterized by the painful and disagreeable sensation that occurs in the breast during walking. This is caused as the result of the myocardial oxygen supply and demand imbalance.  The oxygen demand increases due to tachycardia, hypertension, left ventricular hypertrophy.  Tissue ischemia leads to series of metabolic changes which includes elevated intracellular lactate production and acidification that produces anginal symptoms.  Besides coronary obstructive diseases,

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Sushil, Kumar, Kumari Asha, and Babu Raman Ram. "A Cross Sectional Observational Assessment of the Prescription Pattern in Ischemic Heart Disease." International Journal of Toxicological and Pharmacological Research 13, no. 6 (2023): 168–73. https://doi.org/10.5281/zenodo.11160988.

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<strong>Aim: </strong>The aim of the present study was to analyze the drug prescribing pattern for treatment of ischemic heart disease. <strong>Methods: </strong>This was a cross sectional observational study conducted on ischemic heart disease patients admitted at inpatient department of Medicine in Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga, Bihar, India for 18 months. The study consisted of analysis of drug utilization pattern of prescribed drugs. A total number of 200 patients were enrolled in the study. <strong>Results: </strong>IHD was more c

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Kumar, Rajesh, Chakrapani Kumar, Pramod Kumar Manjhi, Akhilesh Kumar Rana, and Shuvasree Payra. "Economic Evaluation of Different Brands of Commonly Prescribed Drugs Used in the Management of Angina Pectoris in Indian Market." International Journal of Current Research and Review 15, no. 06 (2023): 01–05. http://dx.doi.org/10.31782/ijcrr.2023.15601.

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Introduction: Coronary artery disease (CAD) is one of the most common causes of cardiovascular mortality and morbidity in developing countries like India. Initial management includes use of many anti- anginal drugs. If angina pectoris not managed adequately results in significant morbidity and mortality too due to the complications. Anti-anginal drugs are used for lifelong. Therefore, analysis of the price of different drugs used in ischemic heart disease will help to improve patient compliance. Objective: (1) To assess the cost variation of different drugs available as antianginal agents in I

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Faulhaber, H. D., I. Weigmann, U. Lang, F. Weinsberg, and B. Terhaag. "Anti-anginal and anti-ischemic effects of the selective b-blocker talinolol in patients with stable angina pectoris." Int. Journal of Clinical Pharmacology and Therapeutics 43, no. 02 (2005): 63–70. http://dx.doi.org/10.5414/cpp43063.

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Glezer, M. G., E. I. Astashkin, and M. V. Novikova. "The mechanism of action of metabolic cytoprotector trimetazidine in acute ischemia-reperfusion injury." CardioSomatics 5, no. 2 (2014): 24–30. http://dx.doi.org/10.26442/cs45079.

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The review presents, as the classical data on the mechanism of action of metabolic cytoprotector trimetazidine in acute ischemia/reperfusion injury associated with a partial inhibition of the oxidation of long chain fatty acids and increased metabolism of pyruvate, as well as new concepts of reducing the level of oxidative stress, reduction of cardiomyocyte apoptosis, elimination areas of myocardial stunning and hibernation state. Described cytoprotective effects associated with inhibition of activation of mitochondrial pore with transient (temporary) permeability. Presented clinical studies s

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Pascori, V., G. Colonna, C. Ierardi, et al. "Effect of standard anti-ischemic therapy on anginal episodes in patients with syndrome X." Journal of the American College of Cardiology 31 (1998): 138. http://dx.doi.org/10.1016/s0735-1097(98)81243-6.

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Pasceri, V. "Effect of Standard Anti-Ischemic Therapy on Anginal Episodes in Patients With Syndrome X." Journal of the American College of Cardiology 31, no. 2 (1998): 138A. http://dx.doi.org/10.1016/s0735-1097(97)84304-5.

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Patel, Dhiren, Avinash Guthe, Pravesh Vishwakarma, et al. "In practice usage of extended-release nitrates in patients with angina in the real-world setting: a clinician’s perspective." International Journal of Research in Medical Sciences 12, no. 12 (2024): 4518–21. https://doi.org/10.18203/2320-6012.ijrms20243699.

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Background: Nitrates are highly effective in terminating acute angina pectoris attacks and preventing symptomatic and asymptomatic myocardial ischemia. Methods: This was an observational survey-based study conducted in cardiologists and physicians with clinical expertise in the management of ischemic heart disease from January 2024 to March 2024. Data entry and statistical analysis were done for completed questionnaires and results are expressed in terms of percentages based on the number of responses obtained. Results: A total of 47 clinicians participated in this survey. Nitrates were prefer

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Vlasenko, N. O. "THE ADVANTAGES OF SYDNONIMINES COMPARED TO NITRATES IN THE TREATMENT OF PATIENTS WITH ISCHEMIC HEART DISEASE AND CORONARY INSUFFICIENCY." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 24, no. 1 (2024): 249–57. http://dx.doi.org/10.31718/2077-1096.24.1.249.

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One of the primary challenges in treating patients with coronary artery disease and coronary insufficiency using nitrates is the development of tolerance. Nitrate tolerance is a condition in which the duration and intensity of anti-anginal and anti-ischemic effects decrease, despite maintaining a high concentration of the drug in the blood. In cases of developing tolerance, a continual increase in the nitrate dose is necessary to achieve the previous effect. To eliminate developed nitrate tolerance, discontinuing nitrates for 3-5 days is typically sufficient. Currently, molsidomine is employed

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Khapokhov, I. M., O. V. Kechina, L. M. Malikova, M. V. Makarovskaya, and A. S. Ryazanov. "Current trends in the treatment of chronic ischemic heart disease." Therapist’s Bulletin 65, no. 4 (2024): 18–24. https://doi.org/10.31550/2712-8601-vt-2024-4-3.

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Aim. To present the current trends in the treatment of chronic coronary heart disease. We will focus on optimal drug therapy and the indications for myocardial revascularization. Key points. Based on the latest European guidelines and relevant scientific literature, we will highlight the key aspects of drug treatment for coronary heart disease, such as antithrombotic, lipid-lowering, anti-hypertensive, and anti-anginal medications. We will also discuss the indications and approaches to revascularization through percutaneous coronary intervention and coronary artery bypass surgery. We will cons

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Sawant, Mahadeo P., Sudhir L. Padwal, Rakesh R. Jadhav, Harshal N. Pise, and Rucha Shinde. "Study of drug prescription pattern in ischemic heart disease patients." International Journal of Basic & Clinical Pharmacology 8, no. 7 (2019): 1473. http://dx.doi.org/10.18203/2319-2003.ijbcp20192644.

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Background: Drug utilization pattern studies helps to screen, assess and propose appropriate modifications in prescription practices, this would help to make patient care rational and cost effective. Study was intended to analyse the drug prescribing pattern for treatment of Ischemic heart disease using WHO indicators.Methods: This is a cross sectional observational study conducted on ischemic heart disease patients admitted at inpatient department of medicine in a tertiary care teaching hospital. The study consisted of analysis of drug utilization pattern of prescribed drugs.Results: IHD was

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Borzak, Steven, Terence Fenton, Stephen P. Glasser, et al. "Discordance between effects of anti-ischemic therapy on ambulatory ischemia, exercise performance and anginal symptoms in patients with stable angina pectoris." Journal of the American College of Cardiology 21, no. 7 (1993): 1605–11. http://dx.doi.org/10.1016/0735-1097(93)90375-b.

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Olausson, Karin, Helga Magnusdottir, Leon Lurje, Bertil Wennerblom, Håkan Emanuelsson, and Sven-Erik Ricksten. "Anti-Ischemic and Anti-Anginal Effects of Thoracic Epidural Anesthesia Versus Those of Conventional Medical Therapy in the Treatment of Severe Refractory Unstable Angina Pectoris." Circulation 96, no. 7 (1997): 2178–82. http://dx.doi.org/10.1161/01.cir.96.7.2178.

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Monteiro, Francisco C., Pedro J. Oliveira, Bruno F. Domingues, and Artur Condé. "Nicorandil ulcer: a frequent diagnosis, a rare etiology." International Journal of Otorhinolaryngology and Head and Neck Surgery 4, no. 4 (2018): 1086. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20182719.

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Oral ulcers are a relatively frequent diagnosis in otolaryngology practice. They may have a vast etiology, the iatrogenic medication one of them nicorandil is an anti-ischemic drug used in coronary artery disease and is frequently used in combination with other anti-anginal drugs. There are reports of the association between nicorandil and the appearance of painful oral ulcers, with repercussion on patients' quality of life. The authors describe a case of a 76-year-old man man with ischemic heart disease past that presented to the emergency department complaining of ulcers on the tongue with 1

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Valeeva, E. G., T. V. Martyniuk, K. P. Ivanov, V. B. Sergienko, S. N. Nakonechnikov, and I. Ye Chazova. "THE MODERN VIEW OF THE ADDITIONAL THERAPY, CORRECTING METABOLIC PARAMETERS IN PATIENTS WITH PULMONARY HYPERTENSION: TRIMETAZIDINE IN FOCUS." Eurasian heart journal, no. 4 (December 30, 2016): 18–24. http://dx.doi.org/10.38109/2225-1685-2016-4-18-24.

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SUMMERY According to the Russian data 34% of patients with pulmonary hypertension (PH) have complaints of chest pain. Currently, the cause of this symptoms can be as coronary heart disease, compression of the coronary arteries (usually the left main coronary artery) dilated pulmonary artery, coronary insufficiency due to low cardiac output is relatively weak development of coronary collaterals in the hypertrophy RV wall or a reflex constriction of the coronary arteries due to distension of the pulmonary artery, to the reduction of blood oxygen saturation in the late stages of the disease. Myoc

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Harshada, Patil Sakshi Sonawane Rakesh Khandare* Dr. Aman Upaganlawar Dr. Chandrashekhar Upasani. "An Review on Recent Advancements of Terminalia Arjuna." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2127–40. https://doi.org/10.5281/zenodo.15235155.

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Medicinal plants have historically served as a primary source of therapeutic compounds, providing natural solutions for disease management. <em>Terminalia arjuna </em>is a prominent example of a botanical species widely utilized in indigenous medicine, demonstrating significant potential in the treatment of various critical conditions. "<em>Terminalia arjuna</em>, commonly known as <em>Arjuna</em>, is a plant that belongs to the Combretaceae family." <em>Terminalia Arjuna </em>is a deciduous tree from the Combretaceae family, commonly found along rivers and streams in India's Indo-sub-Himalaya

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Merhel, Tetiana V., Tetiana V. Naluzhna, and Khrystyna V. Levandovska. "Features of complex medicamental therapy in patients with silent myocardial ischemia of high risk after myocardial infarction." Wiadomości Lekarskie, no. 2 (February 28, 2025): 328–35. https://doi.org/10.36740/wlek/201337.

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Aim: To determine the peculiarities of the course of silent myocardial ischemia (SMI) in patients with post-infarction cardiosclerosis depending on the risk factors (RFs); to reveal the interdependence between the presence of pathological turbulence of the heart rhythm and the peculiarities of the course of SMI in patients with post-infarction cardiosclerosis and the effectiveness of treatment applying S-amlodipine and enalapril in complex therapy. Materials and Methods: There were observed 154 patients with SMI with a history of myocardial infarction, having received anti-anginal therapy. The

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Drogovoz, S. M., L. B. Ivantsyk, Yu V. Stoletov, A. L. Shtroblya, A. V. Kononenko, and K. V. Drogovoz. "Possibilities of carboxytherapy for diseases of the cardiovascular system." Likarska sprava, no. 7-8 (December 30, 2020): 31–38. http://dx.doi.org/10.31640/jvd.7-8.2020(4).

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The aim of the study was to analyze the mechanisms of action and pharmacodynamics of carboxytherapy in diseases of the cardiovascular system (CVS). Materials and methods. An analysis of domestic and foreign experience in the use of carboxytherapy for diseases of CVS. Results and discussions. The mechanism of action of carboxytherapy is based on the principle of the introduction of carbon dioxide (CO2) in the patient's body, due to which many pathological disorders can be eliminated. Inhalation and non-inhalation introduction of CO2 into the body has been used for medicinal purposes for many de

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Roy, Ayan, and Nayan Kumar Patel. "Prescribing patterns of cardiovascular drugs in cardiology outpatient department in a tertiary care hospital in Western Odisha." International Journal of Basic & Clinical Pharmacology 10, no. 1 (2020): 23. http://dx.doi.org/10.18203/2319-2003.ijbcp20205533.

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Background: Cardiovascular morbidity plays a villainous role globally as well as countries like India. Additionally, irrational prescription incurs greater damage to health and wellbeing. Drug utilization studies scrutinize the appropriateness of treatment and provide favorable feedbacks to strengthen clinical practices. The objective of the study was to describe treatment practices in cardiology outpatient and drug utilization pattern using core prescribing indicators by World Health Organization (WHO).Methods: A cross-sectional, observational study of 4-month duration was undertaken for card

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Solovyan, A. M., T. V. Міkhalieva, and L. O. Androsova. "Current achievements and prospects for the use of nebivolol in the treatment of patients with cardiovascular diseases." Medicine of Ukraine, no. 3(269) (April 25, 2023): 15–21. http://dx.doi.org/10.37987/1997-9894.2023.3(269).281694.

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A literature review deals with the clinical use of nebivol as a beta-blocker (BB) with vasodilating properties. The principal pharmacological properties and characteristics of the drug, its cardioselectivity and mechanisms of vasodilation are presented. The special place of nebivolol in the treatment of essential arterial hypertension (AH), coronary heart disease (CHD) and heart failure (HF) is outlined. The drug does not possess a diabetogenic activity with a long-term use, and impacts favourably on the parameters of lipid and carbohydrate metabolism. In CHD patients, nebivolol demonstrates t

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Jolicoeur, E. Marc, Michael L. Amalfitano, and Henry Sun. "A RANDOMIZED CONTROLLED TRIAL TO CONFIRM THE ANTI-ANGINAL EFFECT OF T89 IN PATIENTS WITH STABLE ISCHEMIC HEART DISEASE (ORESA): RATIONALE AND DESIGN." Journal of the American College of Cardiology 81, no. 8 (2023): 1134. http://dx.doi.org/10.1016/s0735-1097(23)01578-4.

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Streltsova, N. N., and A. P. Vasiliev. "Anti-ischemic effect and cardiodynamic changes under low-intensive laser irradiation compared to the obsidan effect in patients with angina pectoris." Laser Medicine 25, no. 2 (2021): 9–15. http://dx.doi.org/10.37895/2071-8004-2021-25-2-9-15.

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Purpose: to estimate the anti-anginal effect and to assess changes in hemodynamic parameters in patients with angina pectoris (AP) under low-intensive laser irradiation and to compare them with those under Obsidan preparation administration.Materials and methods. 70 males with AP of functional class I–IV were enrolled in the study and randomized into 2 equivalent groups: Group 1 – patients who took Obsidan; Group 2 — patients who were treated with infrared laser light. Patients were examined at the initial stage-one hour after 40 mg Obsidan take (Group 1), and one month after 10-day course of

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Elyubaeva, Irina, O. L. Barbarash, O. M. Polikutina, Y. V. Khomitskaya, B. B. Kvasnikov, and Y. P. Burtsev. "ANTI-ISCHEMIC EFFECTIVENESS OF TRIMETAZIDINE 80 MG ONCE DAILY IN PATIENTS WITH STABLE ANGINA AND A HISTORY OF MYOCARDIAL INFARCTION. RESULTS OF THE METHOD STUDY." Journal of Hypertension 42, Suppl 1 (2024): e116. http://dx.doi.org/10.1097/01.hjh.0001020480.64652.79.

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Objective: To describe the anti-ischemic effectiveness of trimetazidine 80 mg once daily (TMZ OD) in outpatients with symptomatic stable coronary artery disease (CAD) and a history of myocardial infarction (MI) in real clinical practice. Design and method: The METHOD (NCT05210465) was a 6-month single-center observational study. Adult outpatients with symptomatic stable CAD and a history of MI who had been recommended to initiate TMZ OD in addition to the standard antianginal therapy were included. Myocardial ischemia was assessed by stress echocardiography (STE) in speackle tracking mode (STM

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Kothiya, Olvishkumar M., Bhavana A. Patel, Kunal N. Patel, and Madhubhai M. Patel. "FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF IVABRADINE USING 32 FULL FACTORIAL DESIGN." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 59. http://dx.doi.org/10.22159/ijap.2018v10i1.21584.

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Objective: Ivabradine (IB) is anti-Ischemic drug and used for the symptomatic management of stable angina pectoris. IB acts by reducing the heart rate in a mechanism different from beta blockers and calcium channel blockers, two commonly prescribed anti-anginal drugs. IB has a short biological half-life and the dose of 5/7.5 mg twice a day. In this present study, an attempt has been made to prepare sustained release tablet of IB to achieve the desired drug release.Methods: The sustained release polymers, hydroxypropyl methylcellulose K100M (HPMC K100M), guar gum (GG) and xanthan gum (XG) were

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Vasiliev, A. P., and N. N. Streltsova. "Formation of antianginal pharmacotherapy in the historical aspect. From theoretical background to practical effect." Meditsinskiy sovet = Medical Council, no. 17 (October 12, 2022): 27–33. http://dx.doi.org/10.21518/2079-701x-2022-16-17-27-33.

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Angina pectoris is the most common form of chronic coronary insufficiency, treatment of which consists in reducing the number, duration and severity of anginal pains, as well as improving the prognosis: preventing the development of cardiovascular complications such as acute myocardial infarction, life-threatening rhythm disturbances and congestive heart failure. The treatment of coronary artery disease (CAD) has recently undergone significant changes. This is primarily due to the wide introduction into clinical practice of surgical and endovascular methods of myocardial blood flow restoration

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Ajabnoor, Alyaa, and Amnah Mukhtar. "Effect of trimetazidine on the functional capacity of ischemic heart disease patients not suitable for revascularization: Meta-analysis of randomized controlled trials." PLOS ONE 17, no. 2 (2022): e0263932. http://dx.doi.org/10.1371/journal.pone.0263932.

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Objective To explore the effect of adding trimetazidine to other anti-anginal drugs on the functional capacity of ischemic heart disease (IHD) patients not suitable for revascularization when compared to first-line antianginal drugs alone. Methods MEDLINE and EMBASE databases were searched for English-language peer-reviewed randomized controlled trials (RCTs) comparing trimetazidine with first-line antianginal drugs alone or with placebo in IHD patients not suitable for revascularization and were included in this review. Quality of studies were assessed using the Cochrane collaboration “risk o

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Grigoryeva, N. Yu, O. E. Vilkova, M. O. Samolyuk, and K. S. Kolosova. "New opportunities to improve the treatment effectiveness of patients with stable angina." Kardiologiia 60, no. 6 (2020): 47–52. http://dx.doi.org/10.18087/cardio.2020.6.n1135.

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Aim To study the antianginal and heart rate slowing effects in patients with stable angina (SA) who failed to achieve the heart rate (HR) goal and were switched from the beta-blocker (BB) metoprolol tartrate to a combination of metoprolol tartrate and ivabradine.Materials and methods The study included 54 patients with SA not higher than functional class (FC) III (35 (64.8 %) men and 19 (35.2 %) women) aged 59 [48; 77] years. Prior to the study start and at 4 and 8 weeks of follow-up, electrocardiography (ECG) and 24-h ECG monitoring (24h-ECGM) were performed for all patients. The follow-up pe

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Unnisa, Aziz, Ananda K. Chettupalli, Reem S. Alazragi, et al. "Nanostructured Lipid Carriers to Enhance the Bioavailability and Solubility of Ranolazine: Statistical Optimization and Pharmacological Evaluations." Pharmaceuticals 16, no. 8 (2023): 1151. http://dx.doi.org/10.3390/ph16081151.

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Chronic stable angina pectoris is the primary indication for ranolazine (RZ), an anti-anginal drug. The drug has an anti-ischemic action that is unaffected by either blood pressure or heart rate. Due to the first-pass effect, the drug has a reduced bioavailability of 35 to 50%. The study emphasized developing a novel transdermal drug delivery system of nanostructured lipid carriers (NLCs) for delivering RZ. Many pharmaceutical companies employ lipid nanoparticles as biocompatible carriers for medicinal, cosmetic, and biochemical uses. These carriers are appropriate for many applications, such

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Garganeeva, A. A., K. N. Pavlova, and E. A. Kuzheleva. "The effectiveness of resuscitation in patients with acute myocardial infarction according to the population register." Kardiologiia 60, no. 6 (2020): 41–46. http://dx.doi.org/10.18087/cardio.2020.6.n907.

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Aim To study clinical and anamnestic features and tactics of managing patients with acute myocardial infarction (MI) in groups with different effectiveness of resuscitation procedures.Materials and methods Patients were selected using the “Acute Myocardial Infarction Registry” epidemiological program. 219 cases of acute MI recorded from 2007 through 2017, which required emergency life support, were studied. Two groups were formed based on success of the resuscitation: group 1 consisted of patients with acute MI who survived due to the cardiovascular life support (n=61); group 2 included fatal

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Ricci, Fabrizio, Federico Archilletti, and Raffaele De Caterina. "Diagnostic and therapeutic approach to the ACS patient." Global & Regional Health Technology Assessment 9, Suppl. 1 (2022): 2–13. http://dx.doi.org/10.33393/grhta.2022.2389.

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The current management strategy of acute coronary syndromes aims at symptoms relief as well as at specifically antagonizing each of the different pathogenic components of myocardial ischemia, including the pro-thrombotic state, poor coronary flow and myocardial damage. Different approaches are available, including revascularization procedures and pharmacological interventions. Various anti-anginal, anti-thrombotic and anti-coagulant drugs can be used according to individual features and needs, as well as secondary prevention measures based on statin use and ACE-inhibition. The appropriate use

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Zavalskaya, T. V., and V. V. Bogdan. "Influence of antianginal therapy and L-arginine on serum essential aminoacids spectrum among patients with unstable angina." Likarska sprava, no. 1-2 (March 26, 2019): 63–68. http://dx.doi.org/10.31640/jvd.1-2.2019(9).

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The patients with unstable angina (UA) were examined using the method of ion exchange liquid-column chromatography. The content of the substitutable amino acids (AA) in blood serum was determined: ornithine, taurine, aspartic acid, serine, glutamic acid, proline, glycine, alanine, cysteine, tyrosine, glutamine. The patients were divided into two groups: І – 37 people who received cardicet, bisoprolol, atoris, enap, acetylsalicylic acid, clopidogrel; ІІ – 38 people, the therapy of which, in addition to the mentioned drugs, included L-arginine (100 ml intravenous for 10 days). The results of the

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Krishna, Janapati, Vijay Kumar, Narendra Kumar, and Garre Indrani. "Is the Pleotropic Effect of Ranolazine is Due to its Antioxidant Action." Indian Journal of Cardiovascular Disease in Women WINCARS 01, no. 01 (2016): 014–21. http://dx.doi.org/10.1055/s-0038-1656474.

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AbstractBACKGROUND: Ranolazine is indicated as antianginal drug. We observed that it has other pleotropic effects also. So, we want to study the effect of Ranolazine in improvement of left ventricular (LV) function in obstructive coronary artery (CAD) diseased patients along with ACC/AHA guidelines of treatment. And to see the mode of improvement in LV function is due to its antioxidant effect.MATERIALS AND METHODS: We recruited CAD patient between the age group 18-80 yrs with LV dysfunction in whom ischemic component was treated. Cases received ranolazine 500 mg two times a day and controls w

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Rahman, Md Mahbubu, Md Aminur Razzaque, Iftikher Alam, et al. "Cardiac Cephalgia: Angina in the Head." Bangladesh Medical Journal 48, no. 3 (2021): 46–49. http://dx.doi.org/10.3329/bmj.v48i3.51798.

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Cardiac cephalgia is a migraine like headache that occurs during episodes of myocardial ischaemia. Although most of the patients presenting with ischaemic heart disease have chest pain, there are other rare presenting symptoms like cardiac cephalgia. Headache can be the only presentation of coronary artery disease. We report a case of a 57 years-old man, Presenting with only headache during brisk walking, Exercise Tolerance Test (ETT) was positive for Electrocardiograph (ECG) evidence of provocable myocardial ischemia, who latter was diagnosed as double vessel coronary artery diseaseon Coronar

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Gadicherla, Ashish K., David F. Stowe, William E. Antholine, Meiying Yang, and Amadou K. S. Camara. "Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1817, no. 3 (2012): 419–29. http://dx.doi.org/10.1016/j.bbabio.2011.11.021.

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Mehta, Puja K., Tara Sedlak, Tanya Kenkre, et al. "ANGINA AND ANTI-ANGINAL THERAPY IN WOMEN WITH SIGNS AND SYMPTOMS OF ISCHEMIA AND NO OBSTRUCTIVE CORONARY ARTERY DISEASE." Journal of the American College of Cardiology 61, no. 10 (2013): E1490. http://dx.doi.org/10.1016/s0735-1097(13)61490-4.

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Dicusar, Olga, Tatiana Caragea, Mihaela Munteanu, Victoria Ivanov, and Mihail Popovici. "Updates in the management of patients with non-obstructive coronary artery disease." Bulletin of the Academy of Sciences of Moldova. Medical Sciences 78, no. 1 (2024): 156–65. http://dx.doi.org/10.52692/1857-0011.2024.1-78.16.

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A large majority (up to 70%) of patients undergoing coronary angiography because of angina and signs of myocardial ischemia do not have obstructive coronary arteries. The studies carried out in the last decades have shown that microvascular coronary dysfunction (CMD) and epicardial vasospasm are the basic pathophysiological mechanisms of non-obstructive coronary artery disease (CAD), and depending on the underlying mechanism, three clinical endotypes are differentiated: microvascular angina, vasospastic and mixed. Correct diagnosis and endotype-specific treatment of non-obstructive CAD is show

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Hemant, Kumar Dutt, Pratik, Hasan Arshad, and Singh Dhapola Vikram. "Comparative Efficacy and Impact on Quality of Life with Add-on Therapy of Emerging Newer Anti Anginal Drugs in Stable Angina: A Meta-Analysis." International Journal of Toxicological and Pharmacological Research 12, no. 12 (2022): 6–17. https://doi.org/10.5281/zenodo.7537239.

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<strong>Introduction:</strong> Myocardial ischemia, brought on by a discrepancy between myocardial perfusion and oxygen demand, is the usual culprit in cases of angina pectoris. Beta-blockers (BBs) and calcium channel blockers (CCBs) are the drugs of choice for initial treatment of stable angina, with other classes of drugs used in case the first two are insufficient. The development of methods to enhance care for patients with chronic stable angina is ongoing. It was anticipated that this systematic review will help quantify the therapeutic benefit of using Ivabradine, Ranolazine, Trimetazidi

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Najjar, Rami S., Arielle M. Schwartz, Brett J. Wong, Puja K. Mehta, and Rafaela G. Feresin. "Berries and Their Polyphenols as a Potential Therapy for Coronary Microvascular Dysfunction: A Mini-Review." International Journal of Molecular Sciences 22, no. 7 (2021): 3373. http://dx.doi.org/10.3390/ijms22073373.

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Ischemia with no obstructive coronary artery disease (INOCA) is a common diagnosis with a higher prevalence in women compared to men. Despite the absence of obstructive coronary artery disease and no structural heart disease, INOCA is associated with major adverse cardiovascular outcomes as well a significant contributor to angina and related disability. A major feature of INOCA is coronary microvascular dysfunction (CMD), which can be detected by non-invasive imaging and invasive coronary physiology assessments in humans. CMD is associated with epicardial endothelial-dependent and -independen

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Swapna, P. V. Devi, and G. Saravanan. "A comprehensive analysis of analytical techniques for the quantification of ivabradine and trimetazidine." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 04 (2024): 529. https://doi.org/10.59467/ijhc.2024.34.529.

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Ivabradine, chemically (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino) propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride is mainly used in treating patients with heart failure having the heartbeat of above 70 bpm. It diminishes the heartbeat by blocking the If. Trimetazidine (TMZ) is piperazine derivative. It is chemically 1-(2,3,4-trimethoxy benzyl), piperazine. It has cytoprotective properties that normalize metabolic disturbances in low-flow ischemia, but the drug is mainly known for its anti-anginal activity. This review prese

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Aghababyan, I. R., Yu A. Ismoilova, and Sh Sh Sadykova. "Infusion therapy in treatment of patients with acute coronary syndrome." Infusion & Chemotherapy, no. 3.1 (October 11, 2020): 5–6. http://dx.doi.org/10.32902/2663-0338-2020-3.1-01.

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Objective. Introduction to the basic therapy of patients with acute coronary syndrome (ACS) without ST-segment elevation cardioprotective drug Tivorel (“Yuria-Pharm”) based on L-arginine and L-carnitine. Materials and methods. The present study was carried out in accordance with the requirements for clinical trials of drugs in the Department of Emergency Cardiology of the RSCEMPSF. Patients were admitted to the intensive care unit with a diagnosis of ACS without ST-segment elevation in the first 12 h after the onset of the disease. The study was carried out in two groups and included the

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INO-OKA, Eiji, Kohichi SAGAWA, Takayuki TAKAHASHI, Hikaru INOOKA, Yoshiharu KUTSUWA, and Showko UMEDA. "Efficacy of Anti-anginal Drugs in the Treatment of Angina Pectoris Associated with Silent Myocardial Ischemia. Importance of Quantitative Holter ECG Data for Patient Activity." Internal Medicine 39, no. 12 (2000): 1027–37. http://dx.doi.org/10.2169/internalmedicine.39.1027.

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Greenstein, Lisa B., John L. Hatch, and Thomas P. Sherrin. "Ongoing Continuous Quality Improvement Strategy Using Pharmacological Stress with Intravenous Dipyridamole and Pharmacist Intervention to Reduce Suboptimal Exercise Myocardial Perfusion Scans." Journal of Pharmacy Practice 7, no. 3 (1994): 89–92. http://dx.doi.org/10.1177/089719009400700304.

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Exercise electrocardiogram (ECG) testing in conjunction with radionuclide imaging provides prognostic, diagnostic, and important physiological information regarding the presence of ischemia. However, many patients cannot or will not exercise to 85% of maximal heart rate. When this occurs, potential disparities in regional myocardial perfusion may not be apparent. Pharmacological stress testing with intravenous (IV) dipyridamole provides an alternative method of increasing intracoronary blood flow in these patients and decreasing the incidence of suboptimal exercise myocardial perfusion scans.

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