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Journal articles on the topic 'Anti-arrhythmic strategy'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

NAKAZATO, YUJI. "Current Strategy of Anti-arrhythmic Drug Therapy for Persistent Atrial Fibrillation." Juntendo Medical Journal 63, no. 5 (2017): 373–77. http://dx.doi.org/10.14789/jmj.63.373.

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Bond, Richard, Brian Olshansky, and Paulus Kirchhof. "Recent advances in rhythm control for atrial fibrillation." F1000Research 6 (October 3, 2017): 1796. http://dx.doi.org/10.12688/f1000research.11061.1.

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Atrial fibrillation (AF) remains a difficult management problem. The restoration and maintenance of sinus rhythm—rhythm control therapy—can markedly improve symptoms and haemodynamics for patients who have paroxysmal or persistent AF, but some patients fare well with rate control alone. Sinus rhythm can be achieved with anti-arrhythmic drugs or electrical cardioversion, but the maintenance of sinus rhythm without recurrence is more challenging. Catheter ablation of the AF triggers is more effective than anti-arrhythmic drugs at maintaining sinus rhythm. Whilst pulmonary vein isolation is an ef

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Wagner, Michael, Mirna S. Sadek, Nataliya Dybkova, et al. "Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression." International Journal of Molecular Sciences 22, no. 9 (2021): 4816. http://dx.doi.org/10.3390/ijms22094816.

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Background: Phosphodiesterases (PDE) critically regulate myocardial cAMP and cGMP levels. PDE2 is stimulated by cGMP to hydrolyze cAMP, mediating a negative crosstalk between both pathways. PDE2 upregulation in heart failure contributes to desensitization to β-adrenergic overstimulation. After isoprenaline (ISO) injections, PDE2 overexpressing mice (PDE2 OE) were protected against ventricular arrhythmia. Here, we investigate the mechanisms underlying the effects of PDE2 OE on susceptibility to arrhythmias. Methods: Cellular arrhythmia, ion currents, and Ca2+-sparks were assessed in ventricular

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Mezache, Louisa, Gerard Nuovo, and Rengasayee Veeraraghavan. "A Multipronged Microscopy Approach Identifies Common Anti-Arrhythmic Strategy for Atrial Fibrillation and Myocardial Infarction." Microscopy and Microanalysis 27, S1 (2021): 572–73. http://dx.doi.org/10.1017/s1431927621002476.

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Ng, F. S., A. R. Lyon, I. T. Shadi, et al. "D Modulation of gap junctional coupling as an anti-arrhythmic strategy to prevent reperfusion ventricular arrhythmias." Heart 96, Suppl 1 (2010): A2.2—A3. http://dx.doi.org/10.1136/hrt.2010.196113.17.

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Mezache, Louisa, Gerard Nuovo, and Rengasayee Veeraraghavan. "B-PO04-138 VASCULAR BARRIER PROTECTION: A COMMON ANTI-ARRHYTHMIC STRATEGY FOR ATRIAL FIBRILLATION AND MYOCARDIAL INFARCTION." Heart Rhythm 18, no. 8 (2021): S335—S336. http://dx.doi.org/10.1016/j.hrthm.2021.06.832.

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Huang, Weiting, Felix YJ Keng, and Chi Keong Ching. "Rate or Rhythm Control of Atrial Fibrillation – Pearls for the Internist." Annals of the Academy of Medicine, Singapore 46, no. 11 (2017): 433–38. http://dx.doi.org/10.47102/annals-acadmedsg.v46n11p433.

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Atrial fibrillation is an epidemic in Asia that is increasingly prevalent. Apart from stroke risk stratification and management of anticoagulation, physicians managing this group of patients also need to determine an optimal strategy in terms of rate or rhythm control. With new techniques of catheter ablation to maintain patients in sinus rhythm, patients with atrial fibrillation now have more options for treatment, on top of pharmacological methods. This paper aims to review the current evidence for rate and rhythm control in both general patients and subgroups of interest commonly encountere

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Brizzi, Antonella, Alfonso Trezza, Ottavia Spiga, et al. "2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: Synthesis, In Silico Analysis and In Vitro Pharmacological Evaluation." Molbank 2021, no. 3 (2021): M1258. http://dx.doi.org/10.3390/m1258.

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Quercetin and ferulic acid are two phytochemicals extensively represented in the plant kingdom and daily consumed in considerable amounts through diets. Due to a common phenolic structure, these two molecules share several pharmacological properties, e.g., antioxidant and free radical scavenging, anti-cancer, anti-inflammatory, anti-arrhythmic, and vasorelaxant. The aim of the present work was the combination of the two molecules in a single chemical entity, conceivably endowed with more efficacious vasorelaxant activity. Preliminary in silico studies herein described suggested that the new hy

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Migliore, Federico, Giulia Mattesi, Alessandro Zorzi, et al. "Arrhythmogenic Cardiomyopathy—Current Treatment and Future Options." Journal of Clinical Medicine 10, no. 13 (2021): 2750. http://dx.doi.org/10.3390/jcm10132750.

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Arrhythmogenic cardiomyopathy (ACM) is an inheritable heart muscle disease characterised pathologically by fibrofatty myocardial replacement and clinically by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). Although, in its original description, the disease was believed to predominantly involve the right ventricle, biventricular and left-dominant variants, in which the myocardial lesions affect in parallel or even mostly the left ventricle, are nowadays commonly observed. The clinical management of these patients has two main purposes: the prevention of SCD and the control of arr

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Palazzuoli, Alberto, Matteo Beltrami, and Peter A. McCullough. "Acute COVID-19 Management in Heart Failure Patients: A Specific Setting Requiring Detailed Inpatient and Outpatient Hospital Care." Biomedicines 11, no. 3 (2023): 790. http://dx.doi.org/10.3390/biomedicines11030790.

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The relationship existing between heart failure (HF) and COVID-19 remains questioned and poorly elucidated. Many reports suggest that HF events are reduced during pandemics, although other studies have demonstrated higher mortality and sudden death in patients affected by HF. Several vascular, thrombotic, and respiratory features may deteriorate stable HF patients; therefore, the infection may directly cause direct myocardial damage, leading to cardiac function deterioration. Another concern is related to the possibility that antiviral, anti-inflammatory, and corticosteroid agents commonly emp

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11

Lin, Jiunn-Cherng, Cheng-Hung Li, Yun-Yu Chen, et al. "Rhythm Control Better Prevents Dementia than Rate Control Strategies in Patients with Atrial Fibrillation—A Nationwide Cohort Study." Journal of Personalized Medicine 12, no. 4 (2022): 572. http://dx.doi.org/10.3390/jpm12040572.

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Background: Atrial fibrillation (AF) increases the risk of dementia. Whether the pharmacological rhythm control of AF can reduce the risk of dementia compared to the rate control strategy remains unclear. We hypothesize that the rhythm control strategy is better than the rate control strategy in preventing dementia. Methods: AF patients aged ≥65 years were identified from the Taiwan National Health Insurance Database. Patients receiving anti-arrhythmic drugs at a cumulative defined daily dose (cDDD) of >30 within the first year of enrollment constituted the rhythm control group. Patients wh

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Choi, Ji-Hoon, and Chang Hee Kwon. "Real-World Outcomes of a Rhythm Control Strategy for Atrial Fibrillation Patients with Reduced Left Ventricular Ejection Fraction (<50%)." Journal of Clinical Medicine 13, no. 11 (2024): 3285. http://dx.doi.org/10.3390/jcm13113285.

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Background/Objectives: The effectiveness of a rhythm control strategy in patients with atrial fibrillation (AF) and reduced left ventricular ejection fraction (LVEF < 50%) in real-world practice remains uncertain. Our objective was to evaluate the real-world outcomes of a rhythm control strategy in patients with AF and reduced LVEF, focusing on changes in LV systolic function and brain natriuretic peptide (BNP) levels. Methods: The study retrospectively reviewed the medical records of 80 patients with concurrent AF and reduced LVEF who underwent rhythm control therapy between March 2015 and

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Kossaify, Antoine. "Vernakalant in Atrial Fibrillation: A Relatively New Weapon in the Armamentarium Against an Old Enemy." Drug Target Insights 13 (January 2019): 117739281986111. http://dx.doi.org/10.1177/1177392819861114.

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Atrial fibrillation is the most common sustained cardiac arrhythmia, and its prevalence is increasing with age; also it is associated with significant morbidity and mortality. Rhythm control is advised in recent-onset atrial fibrillation, and in highly symptomatic patients, also in young and active individuals. Moreover, rhythm control is associated with lower incidence of progression to permanent atrial fibrillation. Vernakalant is a relatively new anti-arrhythmic drug that showed efficacy and safety in recent-onset atrial fibrillation. Vernakalant is indicated in atrial fibrillation (⩽7 days

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Liu, Daiqi, Xuyao Han, Zhiwei Zhang, Gary Tse, Qingmiao Shao, and Tong Liu. "Role of Heat Shock Proteins in Atrial Fibrillation: From Molecular Mechanisms to Diagnostic and Therapeutic Opportunities." Cells 12, no. 1 (2022): 151. http://dx.doi.org/10.3390/cells12010151.

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Heat shock proteins (HSPs) are endogenous protective proteins and biomarkers of cell stress response, of which examples are HSP70, HSP60, HSP90, and small HSPs (HSPB). HSPs protect cells and organs, especially the cardiovascular system, against harmful and cytotoxic conditions. More recent attention has focused on the roles of HSPs in the irreversible remodeling of atrial fibrillation (AF), which is the most common arrhythmia in clinical practice and a significant contributor to mortality. In this review, we investigated the relationship between HSPs and atrial remodeling mechanisms in AF. Pub

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Lin, Jie, Haihuan Lin, Zhijun Xu, et al. "Angiogenesis in Atrial Fibrillation: A Literature Review." Biomedicines 13, no. 6 (2025): 1399. https://doi.org/10.3390/biomedicines13061399.

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Atrial fibrillation (AF), the most prevalent clinically significant cardiac arrhythmia, is characterized by chaotic atrial electrical activity and currently affects an estimated 2.5–3.5% of the global population. Its pathogenesis involves ion channel dysfunction, inflammatory cascades, and structural remodeling processes, notably fibrosis. Angiogenesis, the physiological/pathological process of new blood vessel formation, plays a multifaceted role in AF progression. This review synthesizes evidence highlighting angiogenesis’s dual role in AF pathogenesis: while excessive or dysregulated angiog

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Hartmann, Nico, Maria Knierim, Wiebke Maurer, et al. "NaV1.8 as Proarrhythmic Target in a Ventricular Cardiac Stem Cell Model." International Journal of Molecular Sciences 25, no. 11 (2024): 6144. http://dx.doi.org/10.3390/ijms25116144.

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The sodium channel NaV1.8, encoded by the SCN10A gene, has recently emerged as a potential regulator of cardiac electrophysiology. We have previously shown that NaV1.8 contributes to arrhythmogenesis by inducing a persistent Na+ current (late Na+ current, INaL) in human atrial and ventricular cardiomyocytes (CM). We now aim to further investigate the contribution of NaV1.8 to human ventricular arrhythmogenesis at the CM-specific level using pharmacological inhibition as well as a genetic knockout (KO) of SCN10A in induced pluripotent stem cell CM (iPSC-CM). In functional voltage-clamp experime

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Lomidze, N. N., V. A. Vaskovskiy, M. V. Yashkov, E. A. Artukhina, and A. Sh Revishvili. "OPPORTUNITIES AND FUTURE PERSPECTIVES FOR REMOTE MONITORING OF PATIENTS WITH IMPLANTED DEVICES." Complex Issues of Cardiovascular Diseases 8, no. 2 (2019): 98–106. http://dx.doi.org/10.17802/2306-1278-2019-8-2-98-106.

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Today implantable cardiac devices (ICD) are advanced therapeutic and preventive tools ensuring the collection and transmission of statistical and diagnostic patient data. The information obtained from implanted devices allows analyzing patients’ condition, selecting optimal treatment strategy, predicting and preventing possible complications. The number of ICD recipients is rapidly growing. Over 1,000 devices per 1 million population are implanted in Europe and the US annually. In the Russian Federation this number reaches 300 devices per 1 million population. Routine medical checkups of patie

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18

Levitt, Catherine V., Caitlin A. Williams, Jalil Ahari, and Ali Pourmand. "Approach to Decompensated Right Heart Failure in the Acute Setting." Journal of Clinical Medicine 13, no. 3 (2024): 869. http://dx.doi.org/10.3390/jcm13030869.

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Acute right heart failure (ARHF) arises when the right ventricle fails to pump blood efficiently to the pulmonary circulation. This inefficiency leads to a decreased blood supply to various organs. ARHF is a significant health concern, often leading to increased hospital admissions and being associated with a higher risk of mortality. This condition underscores the importance of effective cardiac care and timely intervention to manage its complications and improve patient outcomes. Diagnosing ARHF involves a comprehensive approach that includes a physical examination to evaluate the patient’s

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19

Haldar, Shouvik, Habib Rehman Khan, Vennela Boyalla, et al. "Catheter ablation vs. thoracoscopic surgical ablation in long-standing persistent atrial fibrillation: CASA-AF randomized controlled trial." European Heart Journal 41, no. 47 (2020): 4471–80. http://dx.doi.org/10.1093/eurheartj/ehaa658.

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Abstract Aims Long-standing persistent atrial fibrillation (LSPAF) is challenging to treat with suboptimal catheter ablation (CA) outcomes. Thoracoscopic surgical ablation (SA) has shown promising efficacy in atrial fibrillation (AF). This multicentre randomized controlled trial tested whether SA was superior to CA as the first interventional strategy in de novo LSPAF. Methods and results We randomized 120 LSPAF patients to SA or CA. All patients underwent predetermined lesion sets and implantable loop recorder insertion. Primary outcome was single procedure freedom from AF/atrial tachycardia

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Berte, Benjamin, Gabriella Hilfiker, Federico Moccetti, et al. "Pulmonary vein isolation using ablation index vs. CLOSE protocol with a surround flow ablation catheter." EP Europace 22, no. 1 (2019): 84–89. http://dx.doi.org/10.1093/europace/euz244.

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Abstract Aims Pulmonary vein isolation (PVI) using ablation index (AI) incorporates stability, contact force (CF), time, and power. The CLOSE protocol combines AI and ≤6 mm interlesion distance. Safety concerns are raised about surround flow ablation catheters (STSF). To compare safety and effectiveness of an atrial fibrillation (AF) ablation strategy using AI vs. CLOSE protocol using STSF. Methods and results First cluster was treated using AI and second cluster using CLOSE. Procedural data, safety, and recurrence of any atrial tachycardia (AT) or AF &gt;30 s were collected prospectively.

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Sughimoto, Koichi, Kozo Matsuo, Koichiro Niwa, et al. "Fontan completions over 10 years after Glenn procedures." Cardiology in the Young 24, no. 2 (2013): 290–96. http://dx.doi.org/10.1017/s1047951113000280.

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AbstractObjective: Despite the broadened indications for Fontan procedure, there are patients who could not proceed to Fontan procedure because of the strict Fontan criteria during the early period. Some patients suffer from post-Glenn complications such as hypoxia, arrhythmia, or fatigue with exertion long after the Glenn procedure. We explored the possibility of Fontan completion for those patients.Methods: Between 2004 and 2010, five consecutive patients aged between 13 and 31 years (median 21) underwent Fontan completion. These patients had been followed up for more than 10 years (10 to 13

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Whitaker, John, Paul C. Zei, Shahreen Ahmad, Steven Niederer, Mark O'Neill, and Christopher A. Rinaldi. "The effect of ionizing radiation through cardiac stereotactic body radiation therapy on myocardial tissue for refractory ventricular arrhythmias: A review." Frontiers in Cardiovascular Medicine 9 (September 15, 2022). http://dx.doi.org/10.3389/fcvm.2022.989886.

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Cardiac stereotactic body radiation therapy (cSBRT) is a non-invasive treatment modality that has been recently reported as an effective treatment for ventricular arrhythmias refractory to medical therapy and catheter ablation. The approach leverages tools developed and refined in radiation oncology, where experience has been accumulated in the treatment of a wide variety of malignant conditions. However, important differences exist between rapidly dividing malignant tumor cells and fully differentiated myocytes in pathologically remodeled ventricular myocardium, which represent the respective

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Dunnington, Gansevoort H., Carrie L. Pierce, Susan Eisenberg, et al. "A heart-team hybrid approach for atrial fibrillation: a single-centre long-term clinical outcome cohort study." European Journal of Cardio-Thoracic Surgery, July 13, 2021. http://dx.doi.org/10.1093/ejcts/ezab197.

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Abstract OBJECTIVES The Cox-maze IV is the gold standard for surgical ablation of atrial fibrillation (AF). A heart-team hybrid approach using selected epicardial thoracoscopic surgical ablations and completion endocardial ablations to replicate the Cox-maze IV lesion set has gained popularity and early results have been promising. We herein report our single-centre long-term clinical outcomes using the heart-team hybrid approach with 455 patients. METHODS From 1 March 2013 to 1 July 2019, we prospectively collected data on all patients referred to our heart team for rhythm-control strategy fo

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He, Yu, Alexander Grassam-Rowe, Ming Lei, and James S. H. Bae. "Targeting p21-activated kinase 1 for development of a novel anti-arrhythmic drug class." Philosophical Transactions of the Royal Society B: Biological Sciences 378, no. 1879 (2023). http://dx.doi.org/10.1098/rstb.2022.0285.

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Evidence accumulated over the past decade suggests that p21-activated kinase 1 (PAK1) is a critical cardiac-protective signalling molecule. The present article provides an updated review of recent findings regarding the role of PAK1 in maintaining normal cardiac electrophysiological function through its regulation of membrane and Ca 2+ clocks. We first overviewed the PAK1 activation mechanism. We then discussed recent updated results showing the action mechanisms of PAK1 signalling on Cav1.2/Cav1.3 (I CaL )-mediated Ca 2+ entry, ryanodine receptor type 2-mediated sarcoplasmic reticulum (SR) Ca

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Aggarwal, Ishita, Bahaa Al-azzam, Annette Diaz, et al. "Abstract 11171: Smoking Modulates Response to Anti-Arrhythmic Therapy for Atrial Fibrillation Patients Across Race-Ethnicity." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.11171.

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BACKGROUND: Smoking is associated with increased risk of developing atrial fibrillation (AF) and stroke. Yet, it remains unclear if it also predicts response to rhythm control therapy across race-ethnicity. We sought to determine if response to rhythm control therapy for AF is modulated by smoking across race-ethnicity. Methods: 529 patients treated with a rhythm control strategy were prospectively enrolled in the Chicagoland area. Patients were classified into White, Black or Hispanic\Latino based on race\ethnicity and ancestry markers. Rhythm control included antiarrhythmic drugs (AADs) and/

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Yoshii, T., T. Kitai, T. Sakamoto, et al. "Characteristics, clinical presentation and treatment in older patients with cardiac sarcoidosis." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.884.

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Abstract Background Patients with cardiac sarcoidosis have high risks of heart failure and lethal arrhythmic events, and often require comprehensive therapies including medications for heart failure, anti-arrhythmic drugs, and immunosuppressive therapy in addition to implantable device therapies. However, controversy exist whether these treatments should be applied to the elderly patients. Purpose The aim of this study was to investigate whether older age affects treatment strategy in patients with cardiac sarcoidosis. Methods A total of 4,566 patients with hospitalized cardiac sarcoidosis wer

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Al-Hadithi, Ali B. A. K., and Noel G. Boyle. "A Clinical Review of Ventricular Arrhythmias in Patients with Congestive Heart Failure." EMJ Cardiology, September 6, 2019. http://dx.doi.org/10.33590/emjcardiol/10311539.

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Heart failure is an increasingly prevalent condition, which is associated with ventricular arrhythmias. The reduction in cardiac pumping efficiency leads to the activation of several compensatory mechanisms. These mechanisms eventually lead to cardiac remodelling and a decline in haemodynamic status, contributing to the formation of a substrate conducive to arrhythmias, including increased automaticity, triggered activity, and, most commonly, re-entry circuits. In turn, ventricular arrhythmias can lead to the worsening of heart failure. A diagnosis of heart failure and ventricular arrhythmias

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Bolderman, Robert W., Rob J. Hermans, Leonard M. Rademakers, et al. "Abstract 4098: Epicardial Amiodarone-Releasing Hydrogel Reduces Inducibility of Atrial Fibrillation in Goats." Circulation 118, suppl_18 (2008). http://dx.doi.org/10.1161/circ.118.suppl_18.s_828.

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Amiodarone (AM) is one of the most effective anti-arrhythmic drugs to prevent postoperative atrial fibrillation (AF). However, due to systemic side effects, prophylactic AM therapy is only appropriate for patients at high risk for postoperative AF. This study addressed the hypothesis that local epicardial delivery of AM produces therapeutic myocardial drug concentrations, while systemic levels remain low. Goats (n=14) were instrumented with right atrial epicardial patch electrodes, and a PEG-based hydrogel with AM (1 mg/kg bw) (n=9) or without drug (n=5) was applied to the right atrial epicard

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Rattanawong, P., C. Rayfield, C. Kenyon, A. Seri, T. Yinadsawaphan, and K. Srivathsan. "Long-term follow-up of idiopathic ventricular fibrillation: A 30-year experience from our hospital." Europace 25, Supplement_1 (2023). http://dx.doi.org/10.1093/europace/euad122.272.

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Abstract Funding Acknowledgements Type of funding sources: None. Background/Introduction Idiopathic ventricular fibrillation (IVF) is responsible for 5-7% of sudden cardiac arrests in the absence of substrate for ventricular arrhythmia, structural diseases, or primary arrhythmic syndromes. The characteristics, management, and prognosis of these patients are unclear. Purpose To investigate the clinical features, management, and prognosis of IVF in our hospital healthcare system Methods Mayo Database Explorer software was used to identify IVF patients from our hospital electronic medical records

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Mezache, Louisa, Gerard Nuovo, and Rengasayee Veeraraghavan. "Abstract P333: The Vascular Barrier: A Common Anti-arrhythmic Target In Atrial Fibrillation And Myocardial Infarction." Circulation Research 129, Suppl_1 (2021). http://dx.doi.org/10.1161/res.129.suppl_1.p333.

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Vascular leak is a major sequela of inflammation, which is associated with arrhythmic pathologies such as atrial fibrillation (AF) and myocardial infarction (MI). We recently demonstrated that the vascular leak-inducing cytokine vascular endothelial growth factor (VEGF; 90-580 pg/ml - levels found in AF patients) induces acute remodeling (30-60 minutes) of sodium channel (Na V 1.5) -rich intercalated disk (ID) nanodomains, disrupting their ultrastructure and prompting translocation of Na V 1.5 from these sites. This in turn disrupted impulse propagation and promoted arrhythmias in murine atria

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Politi, Cecilia, Tiziana Ciarambino, Letizia Riva, et al. "Sex-gender and atrial fibrillation treatment in the ATA-AF Study." Italian Journal of Medicine 10 (February 16, 2016). http://dx.doi.org/10.4081/itjm.2016.649.

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Atrial fibrillation (AF) is the most common cardiac arrhythmia. This analysis aimed to determine the sex-gender differences in patients with AF enrolled in the observational ATAAF study. The study was conducted in 360 centers in Italy. During a 4-week period, all consecutive inpatients and outpatients aged ≥18 years, with a documented primary or secondary diagnosis of AF, were included. A total of 7148 patients (47% females) were enrolled. Females were significantly older, they more frequently needed assistance and were affected with severe cognitive impairment. The preferred anti-arrhythmic s

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Hazzy, Fandy, and Ardian Rizal. "C65. Pace and Ablate as an Alternative Approach for Rate Control Strategy in Patient with Atrial Fibrillation." European Heart Journal Supplements 23, Supplement_F (2021). http://dx.doi.org/10.1093/eurheartjsupp/suab125.064.

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Abstract Background AF patient with refractory to optimal medical therapy for rate or rhythm control, atrioventricular (AV) nodal ablation with permanent pacemaker (PPM) implantation is an effective strategy for symptomatic relief. Maintenance of controlled ventricular rate helps to avoid frequent exacerbations of CHF and tachycardia-mediated cardiomyopathy, and is also associated with improved quality of life. Case Summary Female 66-year-old suffered from Heart Failure exacerbations caused by paroxysmal AF with rapid ventricular response (RVR) with underlying hypertensive cardiovascular disea

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Hazzy, Fandy, and Ardian Rizal. "C65. Pace and Ablate as an Alternative Approach for Rate Control Strategy in Patient with Atrial Fibrillation." European Heart Journal Supplements 23, Supplement_F (2021). http://dx.doi.org/10.1093/eurheartjsupp/suab124.064.

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Abstract Background AF patient with refractory to optimal medical therapy for rate or rhythm control, atrioventricular (AV) nodal ablation with permanent pacemaker (PPM) implantation is an effective strategy for symptomatic relief. Maintenance of controlled ventricular rate helps to avoid frequent exacerbations of CHF and tachycardia-mediated cardiomyopathy, and is also associated with improved quality of life. Case Summary Female 66-year-old suffered from Heart Failure exacerbations caused by paroxysmal AF with rapid ventricular response (RVR) with underlying hypertensive cardiovascular disea

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Xia, Eric T., Kevin Lee, Iva Minga, Jose Nazari, and Mark D. Metzl. "Concomitant Treatment of Sustained Ventricular Tachycardia and Hypertrophic Cardiomyopathy with Transcoronary Ethanol Ablation: A Case Report." European Heart Journal - Case Reports, December 23, 2023. http://dx.doi.org/10.1093/ehjcr/ytad632.

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Abstract Background The recommended treatment for recurrent ventricular tachycardia in patients with hypertrophic cardiomyopathy that is not amenable to defibrillator implantation due to shock burden is radiofrequency ablation. In patients with deeply intramural foci of ventricular tachycardia, traditional unipolar ablation has a lower probability of success. Case Summary A 66 year old Caucasian man was admitted with ventricular tachycardia which recurred despite anti-arrhythmic drugs. On cardiac magnetic resonance imaging, he was discovered to have septal hypertrophic cardiomyopathy which was

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Lim, Ha Jeong, Pil-sung Yang, Jung-Hoon Sung, and BOYOUNG JOUNG. "Abstract 15919: Adverse Outcomes Related Amiodarone Toxicity in Early Rhythm Control of Patients With Atrial Fibrillation: A Nationwide Cohort Study." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.15919.

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Background: Early rhythm control therapy was associated with a lower risk of adverse cardiovascular outcomes than usual care among patients who had recently (within 1 year) been diagnosed with atrial fibrillation (AF). In real-world data, the most commonly selected initial rhythm control strategy was the Class III anti-arrhythmic drug (AAD) amiodarone, but adverse outcomes related amiodarone toxicity was not well reported in this population. This study sought to investigate the fatal and non-fatal adverse outcomes related amiodarone toxicity in early rhythm control of patients with AF. Methods

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Wang, Tao, Wei Li, Qianqian Huang, et al. "The Clinical Efficacy and Safety of 11 Commonly Used Treatment Strategies Improving Arrhythmia of CHD in China: A Network Meta-Analysis." Frontiers in Pharmacology 12 (September 20, 2021). http://dx.doi.org/10.3389/fphar.2021.741716.

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Purpose: Arrhythmia which as a common complication of CHD, has a high incidence. At present, more and more anti-arrhythmic drugs are used in clinical practice. However, which drug has the best efficacy and high safety is still unknown. Therefore, we decided to use NMA to solve this problem.Method: We searched CNKI, Wanfang database, VIP database, Pubmed, Embase and Cochrane libraries, and collected all RCTs of arrhythmia of CHD, and used RevMan (5.3) and Stata (13.0) to carry out this NMA. The primary outcome indicator of this study is efficiency; the secondary outcome indicator is the inciden

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Roa, Francisco J., Maria Roubelakis, Konstantinos Paschidis, et al. "Repurposing amiodarone for bladder cancer treatment." Cancer Research Communications, May 12, 2025. https://doi.org/10.1158/2767-9764.crc-24-0433.

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Abstract Cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy is the main treatment for muscle-invasive bladder cancer (MIBC). However, low survival rates highlight the necessity for new therapeutic strategies. Drug repurposing has emerged as a promising approach in cancer treatment, with various studies proposing the use of existing drugs for the treatment of bladder cancer (BC). In this context, we previously established an in silico repurposing strategy using patient -omics signatures, identifying drugs and compounds with the potential to reverse non-muscle invasive BC (N

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Wall, Kevin, Camden Hebson, Roshan D’Souza, and Seshadri Balaji. "Review of rhythm disturbances in patient after fontan completion: epidemiology, management, and surveillance." Frontiers in Pediatrics 13 (February 12, 2025). https://doi.org/10.3389/fped.2025.1506690.

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PurposeThe Fontan operation is commonly associated with alterations in heart rhythms, both tachycardic and bradycardic. Despite modifications to attempt to mitigate these complications, arrythmias still frequently occur. The purpose of this review is to examine the literature regarding the scope of the problem, therapeutic options, and current recommendations regarding screening and surveillance.Recent findingsModifications to the original Fontan procedure, antiarrhythmic medications, and improvements in catheter ablation procedures have improved the management of patients with arrhythmias fol

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Hou, Panpan, Lu Zhao, Ling Zhong, et al. "The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response." PNAS Nexus, October 9, 2024. http://dx.doi.org/10.1093/pnasnexus/pgae452.

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Abstract The cardiac KCNQ1+KCNE1 (IKs) channel regulates heart rhythm in both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cAMP level, leading to KCNQ1 phosphorylation by protein kinase A and increased IKs, which shortens action potentials to adapt to accelerated heart rate. An impaired response to the β-adrenergic stimulation due to KCNQ1 mutations is associated with the occurrence of a lethal congenital long QT syndrome (type 1, also known as LQT1). However, the underlying mechanism of β-adrenergic stimulation of IKs remains unclear, imp

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Yoshida, Akira, Takafumi Oka, Takayuki Sekihara, Tomoaki Nakano, and Yasushi Sakata. "Electrical Isolation of the Cavotricuspid Isthmus Aneurysm: A Novel Strategy for Refractory Atrial Tachyarrhythmias with Complex Anatomical Variants: A Case Report." European Heart Journal - Case Reports, July 15, 2025. https://doi.org/10.1093/ehjcr/ytaf334.

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Abstract Background Cavotricuspid isthmus (CTI) is a part of the reentrant circuit of atrial flutter (AFL), and its linear ablation is the method of choice for treating CTI-dependent AFL. We describe our experience of a case of multiple atrial tachycardias (ATs) originating from the CTI aneurysm and the challenges encountered during its electrophysiological management. Case Summary The patient, a 61-year-old woman with hereditary non-polyposis colorectal cancer, presented with recurrent supraventricular tachycardia resistant to conventional treatment with anti-arrhythmic medication and electri

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Crinion, D., M. H. S. Hassan Shariat, D. G. Gupta, et al. "5203Ablation of scar-related ventricular tachycardia: paced electrogram feature analysis (PEFA) is a novel and effective substrate based strategy." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz746.0061.

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Abstract Background Ablation of scar related ventricular tachycardia (VT) has been shown to be superior to escalation of drug therapy. However, the incremental benefit remains modest, with 42% experiencing recurrent shocks and 64% appropriate anti-tachycardia pacing (ATP) in the VANISH study. Improved ablation strategies are needed. Paced electrogram feature analysis (PEFA) is a novel substrate based ablation technique. Purpose To investigate the effectiveness of the PEFA based VT ablation technique. Methods A single centre, prospective study. Consecutive cases of scar related VT that had an i

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Athanasiou, Athanasios, Marinos Charalambous, Theodora Anastasiou, and Elpidoforos S. Soteriades. "Pre- and post-operative administration of omega-3 polyunsaturated fatty acids in cardiac surgery patients. A narrative review." Annals of Medicine & Surgery, March 18, 2025. https://doi.org/10.1097/ms9.0000000000003061.

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Eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are two biologically active omega-3 polyunsaturated fatty acids (n-3 PUFA), acquired by nutrition and incorporated in cell membranes’ phospholipids, thus playing a crucial role in human health and homeostasis. Due to their potential cardioprotective, anti-inflammatory, and anti-arrhythmic actions, n-3 PUFA emerge as an interesting therapeutic option for cardiac surgery (CS) patients. The aim of this review was to assess the effects of perioperative administration of n-3 PUFA in CS patients. A comprehensive literature search was conduc

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Kim, Daehoon, Pil-Sung Yang, Seng Chan You, et al. "Association of rhythm control with incident dementia among patients with atrial fibrillation: a nationwide population-based cohort study." Age and Ageing 51, no. 1 (2022). http://dx.doi.org/10.1093/ageing/afab248.

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Abstract Background Atrial fibrillation (AF) increases the risk of dementia, and catheter ablation of AF may be associated with a lower risk of dementia. We investigated the association of a rhythm-control strategy for AF with the risk of dementia, compared with a rate-control strategy. Methods This population-based cohort study included 41,135 patients with AF on anticoagulation who were newly treated with rhythm-control (anti-arrhythmic drugs or ablation) or rate-control strategies between 1 January 2005 and 31 December 2015 from the Korean National Health Insurance Service database. The pri

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Zhang, Tao, Xiaojiao Du, Yue Gu, et al. "Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine." Frontiers in Physiology 13 (March 8, 2022). http://dx.doi.org/10.3389/fphys.2022.835198.

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Circadian factors likely influence the occurrence, development, therapy, and prognosis of cardiovascular diseases (CVDs). To determine the association between the heart rate (HR) diurnal parameters and CVD risks, we designed an analytical strategy to detect diurnal rhythms of HR using longitudinal data collected by clinically used Holter monitors and wearable devices. By combining in-house developed algorithms with existing analytical tools, we obtained trough phase and nocturnal variation in HR for different purposes. The analytical strategy is robust and also sensitive enough to identify var

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Nakamura, K., S. M. Marchiano, L. E. Neidig, et al. "Quiescent-yet-excitable pluripotent stem cell-derived cardiomyocytes engraft without fatal arrhythmias in minipig and primates." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.3133.

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Abstract Background Pluripotent stem cell-derived cardiomyocyte (PSC-CM) transplantation is a promising therapy for subacute myocardial infarction (MI), but transient engraftment-related arrhythmia (EA) is major barrier to clinical development (1, 2). We hypothesize that PSC-CM genetically edited to remove automaticity but otherwise functionally intact will engraft in vivo with greater arrhythmic safety. Methods Combinatorial CRISPR/Cas9 genome editing to screen for electrically quiescent PSC-CM yielded a line deficient in the depolarization-associated genes HCN4, CACNA1H, and SLC8A1, combined

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Maqoud, Fatima, Rosa Scala, Malvina Hoxha, Bruno Zappacosta, and Domenico Tricarico. "ATP-sensitive potassium channel subunits in the neuroinflammation: novel drug targets in neurodegenerative disorders." CNS & Neurological Disorders - Drug Targets 20 (January 19, 2021). http://dx.doi.org/10.2174/1871527320666210119095626.

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: Arachidonic acids and its metabolites modulate plenty of ligand-gated, voltage-dependent ion channels, and metabolically regulated potassium channels including ATP-sensitive potassium channels (KATP). KATP channels are hetero-multimeric complexes of sulfonylureas receptors (SUR1, SUR2A or SUR2B) and the pore-forming subunits (Kir6.1 and Kir6.2) likewise expressed in the pre-post synapsis of neurons and inflammatory cells, thereby affecting their proliferation and activity. KATP channels are involved in amyloid-β (Aβ)-induced pathology, therefore emerging as therapeutic targets against Alzhei

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Peichl, Petr, Antoni Bayes-Genis, Thomas Deneke, et al. "Drug therapy and catheter ablation for management of arrhythmias in continuous flow left ventricular assist device's patients. A Clinical Consensus Statement of the European Heart Rhythm Association and the Heart Failure Association of the ESC." Europace, October 31, 2024. http://dx.doi.org/10.1093/europace/euae272.

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Abstract Left ventricular assist devices (LVADs) are an increasingly used strategy for the management of patients with advanced heart failure. Although these devices effectively improve survival, atrial and ventricular arrhythmias are common with a prevalence of 20-50% at one year after LVAD implantation. Arrhythmias predispose these patients to additional risk and are associated with considerable morbidity from recurrent implantable cardioverter-defibrillator (ICD) shocks, progressive failure of the unsupported right ventricle, and herald an increased risk of mortality. Management of patients

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Doll, Nicolas, Antonia Doll, Geza Horvath, et al. "Totally Thoracoscopic Ablation for Atrial Fibrillation: All-Box Clamping." Thoracic and Cardiovascular Surgeon, June 3, 2025. https://doi.org/10.1055/a-2625-9617.

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Abstract Background Epicardial surgical ablation is an effective strategy to treat non-paroxysmal forms of atrial fibrillation. Current thoracoscopic epicardial surgical strategies are complex, and are therefore often avoided. With slight modifications to the thoracoscopic maze procedure, totally thoracoscopic all-box-clamping may facilitate the performance of epicardial thoracoscopic ablation, while maintaining good results. Methods Between December 2023 and December 2024, 42 patients underwent thoracoscopic all-box-clamping at a single center. All-box-clamping uses commercially available bip

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Subramanya, Vinita, J’Neka S. Claxton, Pamela L. Lutsey, et al. "Sex differences in treatment strategy and adverse outcomes among patients 75 and older with atrial fibrillation in the MarketScan database." BMC Cardiovascular Disorders 21, no. 1 (2021). http://dx.doi.org/10.1186/s12872-021-02419-2.

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Abstract Background Women with atrial fibrillation (AF) experience greater symptomatology, worse quality of life, and have a higher risk of stroke as compared to men, but are less likely to receive rhythm control treatment. Whether these differences exist in elderly patients with AF, and whether sex modifies the effectiveness of rhythm versus rate control therapy has not been assessed. Methods We studied 135,850 men and 139,767 women aged ≥ 75 years diagnosed with AF in the MarketScan Medicare database between 2007 and 2015. Anticoagulant use was defined as use of warfarin or a direct oral ant

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Marchetti, M., C. Haddad, A. Luca, et al. "The contribution of pulmonary veins to the mechanism of persistent AF is dependent on their extent of electrical connection." Europace 26, Supplement_1 (2024). http://dx.doi.org/10.1093/europace/euae102.103.

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Abstract Introduction Success rate of pulmonary vein isolation (PVI) is lower in patients with persistent AF (peAF) compared to paroxysmal AF. The indiscriminate use of adjunctive catheter ablation (CA) strategies beyond PVI involve potential risks and new areas of iatrogenic arrhythmogenesis. Thus, distinguishing patients with peAF who may be cured with PVI-only from those who need CA beyond PVI would allow a more efficient patient-tailored CA strategy. Purpose We aimed to evaluate whether the circumferential extent of PV electrical connection assessed during pre-ablation mapping predicts the

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