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Dissertations / Theses on the topic 'Anti-breast cancer drug'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Yaourtis, Andria. "Innate and anti-cancer drug-induced morphological changes in the human breast cancer cell line MDA-MB-231." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/26409.

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Phenotypic changes in tumour cells is a well-established phenomenon and can happen either naturally or in response to a drug. Such changes in phenotype are often accompanied with changes in the behaviour of tumour cells, including growth, proliferation, as well as their migratory and invasive capacity. Phenotypic changes can, therefore, impact the aggressiveness of the tumour cell and dictate their metastatic potential. Thus, it is of utmost importance to fully understand and characterise phenotypic changes in tumour cells in order to better understand tumour progression and identify therapeut

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2

Guardia, Valenzuela Cristina 1990. "Cancer-associated fibroblasts and response to anti-HER2 monoclonal antibodies in breast cancer." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668327.

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El cáncer de mama HER2-positivo es un subtipo muy agresivo. El desarrollo de terapias anti-diana HER2, particularmente el anticuerpo monoclonal (Mab) trastuzumab, supuso una mejora significativa en el pronóstico de esta enfermedad. De manera más reciente, otro Mab llamado pertuzumab, ha mejorado todavía más la eficiencia de trastuzumab. Aún y así, no todas las pacientes se beneficiarán de esta combinación de mAbs. Una proporción de estas pacientes no se beneficiarán de estas terapias anti-HER2, y fallecerán a causa de la presencia o el desarrollo de mecanismos de resistencia. Los tumores con

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3

Lovitt, Carrie Jade. "Exploring Breast Cancer Drug Targets in the Third Dimension with Imaging." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/367232.

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This project utilises innovative methodology to evaluate the suitability of novel three-dimensional (3D) cell culture models for investigating anti-cancer drug activity. 3D cell culture methodology was utilised as this in vitro approach is considered to recapitulate the in vivo conditions more accurately than two-dimensional (2D) monolayer cell culture. Two separate 3D cell culture model formats were developed which are amenable to automated liquid handling systems, and a variety of instruments for total well fluorescence and confocal imaging. The first 3D cell culture assay developed was in a

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4

Bonzi, Gwénaëlle A. M. "Novel polysaccharide anti-tumour drug delivery system for active targeting and controlled release to breast cancer bone metastases." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423664.

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ABSTRACT In the late stage of the disease, breast cancer patients often develop bone metastases, a major cause of cancer-related death among women worldwide. The common treatment currently used clinically includes the anti-neoplastic agent paclitaxel combined with the bisphosphonate alendronate. Paclitaxel is an anti-neoplastic drug which cytotoxic effect is mainly attributed to its ability to promote the assembly of microtubules as well as prevent the depolymerisation of these microtubules. Stabilization of the microtubule networks stops mitotic functions that, in sequence, blocks cell div

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Wan, Xiao. "Development of advanced three-dimensional tumour models for anti-cancer drug testing." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:5342fe46-c676-4fe8-8b6e-96d17a18d17d.

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Animal testing is still the common method to test the efficacy of new drugs, but tissue engineered in vitro models are becoming more acceptable for replacing and reducing animal testing in anti-cancer drug screening by developing in vitro three-dimensional (3D) tumour models for anti-cancer drug testing. In this study, three-dimensional (3D) culture methods were developed to mimic the tumour microenvironment. 3D culturing is to seed, maintain and expand cultured cells in three-dimensional space, in contrast to the traditional two-dimensional (2D) method in which the cells attach to the bottom

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6

Leonardi, Antonio. "Design, synthesis of substituted purines, phenylpyrrolidine derivatives, cyclic and acyclic bis (p-nitrobenzenesulfonamides), and in vitro anti-cancer activity against lung, breast and prostate cell lines." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1175.

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Al momento sono stati classificati più di 100 forme di cancro secondo il tipo di cellula inizialmente affetta. Le patologie tumorali sono caratterizzate da una crescita cellulare incontrollata che porta alla formazione di grumi o masse di tessuto che danneggiano l organismo. Lo sviluppo di nuovi farmaci antitumorali è una delle attività prioritarie nell'ambito della ricerca chimico-farmaceutica, non solo per l alta incidenza ma anche per i numerosi inconvenienti legati ai farmaci in uso. Il progetto di ricerca è stato indirizzato al disegno, sintesi e valutazione biologica di nuovi farmaci ant

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7

Dubois, Clémence. "Optimisation du traitement du cancer du sein Triple-Négatif : développement des modèles de culture cellulaire en trois dimensions, efficacité de l'Olaparib (anti-PARP1) en combinaison avec la radiothérapie et chimiorésistance instaurée par les protéines Multi Drug Résistance." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAS018/document.

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Le cancer du sein est une maladie complexe et difficile à caractériser. Parmi les différents sous-types moléculaires, les tumeurs du sein Triple-Négatives (TN) sont particulièrement agressives et de mauvais pronostic. Elles sont caractérisées par une absence d’expression des récepteurs aux œstrogènes (ER), à la progestérone (PR), l’absence de surexpression du récepteur Human Epidermal growth factor 2 (HER2) et de fréquentes mutations sur les gènes BRCA1/2 (profil « BRCAness »). En absence de thérapies ciblées efficaces, de nombreux traitements ciblés notamment les inhibiteurs de poly-ADP-ribos

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8

Khubieh, J. "Immunoassay of 4-Hydroxyandrostenedione, a new anti-cancer agent." Thesis, University of Surrey, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234454.

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9

Diaz-Cruz, Edgar S. "Interrelationships between aromatase and cyclooxygenase-2 and their role in the autocrine and paracrine mechanisms in breast cancer." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117117648.

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10

Oechsle, Crystal Mae. "The Use and Enhancement of Anti-Cancer Vaccine Therapy with Low-Toxicity Drugs for the Treatment of HER2 Positive Breast Cancer." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1561121654968093.

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11

Cheng, Huiwen. "Effects of N-acetyl-L-cysteine and Nitric Oxide-releasing Nonsteroidal Anti-Inflammatory Drugs on Breast Cancer and Melanoma Cell Adhesion." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1384948906.

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12

Luniwal, Amarjit. "Design, Synthesis, and Process Chemistry Studies of Agents Having Anti-Cancer Properties." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1302801948.

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13

Chakrama, Fatima Zahra. "La protéine Gec1/Gabarapl1 : rôle au cours de l'autophagie et expression dans les cellules cancéreuses." Thesis, Besançon, 2011. http://www.theses.fr/2011BESA3007/document.

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Le gène Gec1/Gabarapl1 a été identifié au sein de notre laboratoire comme un gène régulé par les estrogènes. Il appartient à la famille Gabarap incluant les gènes Gabarap, gabarap/2 et Gabarapl3 qui codent des protéines présentant de fortes homologies de séquences. L'étude fonctionnelle de Gabarapl 1 a montré que cette protéine est impliquée dans le transport des récepteurs et particulièrement les récepteurs Gabaₐ et des κ-opioïdes via son interaction avec la tubuline et la protéine NSF. Cependant, il a été décrit que certaines protéines de la famille Atg8 sont impliquées dans l' autophagie, u

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14

Lin, Chia-Hsien, and 林嘉嫻. "The Anti-Cancer Mechanism of Cyclin D1-Ablative Drug on Breast Cancer." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/tdxjrt.

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碩士<br>國立中山大學<br>生物醫學研究所<br>96<br>Breast cancer is the fifth most common cause of cancer death in the worldwide. In the past decades, tamoxifen has been used for clinical treatment for breast cancers. The derivatives of compound thiazolidinedione (TZDs) including troglitazone (rezulin) and rosiglitazone (avandia) are also in the stages of clinical trials. But in the earlier research, some studies reported that the use of these drugs was associated with some serious side effects. Cyclin D1 plays an important role in G1/S phase cell cycle progression and in growth factor- or estrogen-induced mamm

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15

"Anti-tumor effect of arsenic trioxide (As₂O₃) on human breast cancer." 2007. http://library.cuhk.edu.hk/record=b5893264.

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Zhou, Linli.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 108-118).<br>Abstracts in English and Chinese.<br>Acknowledgements --- p.i<br>Abstract --- p.ii<br>論文摘要 --- p.iv<br>Abbreviations --- p.v<br>List of Figures --- p.vii<br>List of Tables --- p.ix<br>Table of Contents --- p.x<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Breast Cancer --- p.1<br>Chapter 1.1.1 --- Introduction to Breast Cancer --- p.1<br>Chapter 1.1.2 --- Types of Breast Cancer --- p.3<br>Chapter 1.1.3 --- Epidemiologic Risk Factors

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16

"Anti-cancer effects of the products of Ganoderma lucidum, G. tsugae and their artificial hybrid on breast cancer cells." 2005. http://library.cuhk.edu.hk/record=b5896440.

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Luk Wing Yan Vivien.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 207-239).<br>Abstracts in English and Chinese.<br>Acknowledgment --- p.i<br>Abstract --- p.iii<br>摘要 --- p.vi<br>Contents --- p.viii<br>List of Figures --- p.xiv<br>List of Table --- p.xxv<br>Abbreviations --- p.xxv<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Ganoderma spp --- p.1<br>Chapter 1.2 --- Bioactive components of Ganoderma spp --- p.3<br>Chapter 1.2.1 --- Lingzhi polysaccharide --- p.3<br>Chapter 1.2.2 --- Terpenes --- p.4<br

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17

Pontes, Olívia Alexandra Elias. "New chromene-based drug candidates for cancer treatment." Master's thesis, 2017. http://hdl.handle.net/1822/45726.

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Dissertação de mestrado em Bioquímica Aplicada<br>Cancer is a devastating disease worldwide, with millions of diagnoses per year and many people living with this pathology. Breast cancer is one of the major causes of death in women while male breast cancer represents less than 1% of the total male diagnosed population. Due to this increasing cancer incidence, research in this area has been growing at the same rate. Thus, there is an urgency in discovering new drugs for cancer treatment. The chromene scaffold has been identified in several compounds with anticancer activity. The substitut

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18

"Anti-proliferative effect of pheophorbide a-mediated photodynamic therapy on human breast cancer cells: biochemical mechanism in relation to multidrug resistance." 2010. http://library.cuhk.edu.hk/record=b5894343.

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Cheung, Ka Yan.<br>"Aug 2010."<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves 157-167).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>摘要 --- p.iii<br>Acknowledgments --- p.v<br>Table of Contents --- p.vi<br>List of Figures --- p.x<br>List of Tables --- p.xi<br>Abbreviations --- p.xii<br>Chapter Chapter1 --- General Introduction --- p.1<br>Chapter 1.1 --- Cancer epidemiology and managements --- p.2<br>Chapter 1.2 --- Photodynamic therapy (PDT) as cancer treatment --- p.7<br>Chapter 1.3 --- Pheophorbide a (Pa) as

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19

Haggag, Y. A., K. B. Matchett, Robert A. Falconer, et al. "Novel Ran-RCC1 inhibitory peptide-loaded nanoparticles have anti-cancer efficacy in vitro and in vivo." 2019. http://hdl.handle.net/10454/17484.

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Yes<br>The delivery of anticancer agents to their subcellular sites of action is a significant challenge for effective cancer therapy. Peptides, which are integral to several oncogenic pathways, have significant potential to be utilised as cancer therapeutics due to their selectivity, high potency and lack of normal cell toxicity. Novel Ras protein-Regulator of chromosome condensation 1 (Ran-RCC1) inhibitory peptides designed to interact with Ran, a novel therapeutic target in breast cancer, were delivered by entrapment into polyethylene glycol-poly (lactic-co-glycolic acid) PEG-PLGA pol

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20

Ho, Karyn. "Targeted Drug Delivery to Breast Cancer using Polymeric Nanoparticle Micelles." Thesis, 2012. http://hdl.handle.net/1807/34054.

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Broad distribution and activity limit the utility of anti-cancer compounds by causing unacceptable systemic toxicity and narrow therapeutic indices. To improve tumour accumulation, drug-loaded macromolecular assemblies have been designed to replace conventional surfactant-based formulations. Their nanoscale size enhances tumour accumulation via hyperpermeable vasculature and reduced lymphatic drainage. Incorporating targeting ligands introduces cell specificity through receptor-specific binding and uptake, enabling drugs to reach intracellular targets. In this work, the targeting propertie

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21

Lekgau, Karabo. "Design and synthesis of quinoxaline derivatives for medicinal application against breast cancer cells." Thesis, 2021. http://hdl.handle.net/10386/3454.

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Thesis (M.Sc.(Chemistry)) -- University of Limpopo, 2020<br>Breast cancer is a malignant tumour that starts in the cells of the breast. Many studies revealed aromatase (CYP19A1) and cyclin-dependent kinase 2 (CDK2) as possible therapeutic targets regarding breast cancer treatment, because they play crucial roles in anti-apoptotic processes during cell proliferation. Quinoxaline derivatives have attracted a great deal of attention due to their biological activities against fungi, virus, bacteria and cancer. Computer modelling was employed in order to reduce time and cost by searching

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22

伊藤, 裕美. "Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin." Thesis, 2011. http://hdl.handle.net/2237/14839.

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23

Haggag, Y. A., K. B. Matchett, El-Habib Dakir, et al. "Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells." 2017. http://hdl.handle.net/10454/11435.

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Yes<br>Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase peptides, which prevents Ran hydrolysis and activation, and although they display effectiveness in silico, peptide activity is suboptimal in vitro due to reduced bioavailability and poor delivery. To overcome this drawback, we delivered an anti-Ran-GTPase peptide using encapsulation in PLGA-based nanoparticles (NP). Formulation variables within a double emulsion solvent e

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24

Wang, You-Qi, and 王宥棋. "Carnosic Acid Impedes Cell Growth and Enhances Anti- Cancer Effects of Anti-cancer Drugs in Melanoma and Breast Cancer Cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/5ufn96.

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碩士<br>義守大學<br>生物科技學系<br>106<br>Background: Carnosic acid (CA), a major polyphenolic diterpene in Rosmarinus officinalis, has been reported to have multiple functions, including anti-tumor activity. Methods: To evaluate the anti-cancer effects of CA, the human breast cancer cell lines (MCF-7, ZR-75-1, MDA-MB-231, MDA-MB-453, and BT-474), fibroblast cell line (NIH-3T3) and melanoma cell line (B16F10) were used and tested. For the breast cancer cells, MTT assay, wound healing and colony formation were utilized for the detection of cell growth and proliferation. The cell cycle was determined by f

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25

Ximenes, Frota Máximo Ilane. "The impact of nonsteroidal anti-inflammatory drugs on endocrine therapy outcomes in breast cancer patients." 2013. http://hdl.handle.net/2152/22501.

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Obesity is a known risk factor for postmenopausal breast cancer, and is associated with worse disease prognosis in pre- and postmenopausal women. Adjuvant hormonal therapies improve disease prognosis in obese women, but many still recur. Given that obesity induces inflammation and increases levels of cyclooxygenase-2 (COX-2) enzyme, resulting in tumor proliferation, this retrospective study investigated if women on anti-inflammatory drugs would have improved disease outcomes by reduced production of prostaglandins by COX-2 pathway. Four hundred and forty women treated for invasive breast cance

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Su, Yu-Hsiang, and 蘇郁翔. "Risk of depression in patients with breast cancer after receiving different combinations of anti-cancer drugs." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8chsvu.

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碩士<br>國立陽明大學<br>公共衛生研究所<br>106<br>Background and Objectives: In recent years, the incidence of breast cancer in Taiwan has continuously increased. Fortunately, with the advancement of medical technology and the development of various anticancer drugs, the 5-year survival rate of breast cancer cases has improved to more than 80%. However, the prolonged life of cancer patients does not necessarily represent a good quality of life. As a result, more and more cancer care organizations have begun to advocate and emphasize the importance of psychological problems of cancer patients after treatment.

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27

Marques, João Filipe Gonçalves. "Development of intelligent vehicles for co-livery of anti-tumoral drugs to breast cancer cells." Master's thesis, 2013. http://hdl.handle.net/10400.6/3238.

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Presently breast cancer arises as one of the most prevalent malignancy in women worldwide, contributing for high rates of mortality and morbidity in several million patients. Currently there is still no available cure for this disease and to further aggravate this scenario the existing treatments such as chemotherapy, are generally ineffective due to poor tumor bioavailability. Moreover, the commonly used anti-tumoral compounds also lead to the development of drug resistant malignant cells after repeated administration, a fact that originates the development of more aggressive cells that posse

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Liu, Ying-Hsiu, and 劉英秀. "Observing the Pharmaceutical Patents' Development and Portfolio of International Pharmaceutical Company by Patent Analysis - a Case Study of Anti-HER2 Targeted Drugs for Breast Cancer." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/jf5ue7.

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碩士<br>國立臺灣科技大學<br>專利研究所<br>103<br>New drug research and innovation is a high-risk investment in the field of medicine, it has some characteristics, such as from R&D to launch a new drug to market is a time-consuming process and pharmaceutical companies still invest the great cost of capital during this period, pharmaceutical companies in order to improve cost recovery and return on investment, most of all will seek patent right to protect their products. The patent law offers the exclusive right to the inventors in a limited period of time, in this reason, brand name pharmaceutical companies c

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