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Journal articles on the topic 'Anti-cytotoxic effect'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

SOYOCAK, Ahu, Ayşe AK, and Ebru ÖNEM. "Anti-quorum sensing and cytotoxic activity of elemi essential oil." International Journal of Secondary Metabolite 9, no. 3 (2022): 258–67. http://dx.doi.org/10.21448/ijsm.1059886.

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Essential oils have several biological activities such as antimicrobial, antioxidant, proliferative, and anti-inflammatory. This study aimed identification of bioactive compounds found in Elemi essential oil (EO) and to determine the anti-quorum sensing and cytotoxic activities of EO. In this study, bioactive compounds of EO were analyzed using GC-MS, and the antibacterial activity of elemi was screened against Staphylococcus aureus ATCC 25923, Methicillin-Resistant Staphylococcus aureus ATCC 43300, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Pseudomonas aeruginosa PAO1. An

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Vidyalaksh, K. S., A. I. Charles Dorni ., and Hannah R. Vasanthi . "Anti-Mitotic and Cytotoxic Effect of Mussaenda queensirkit." Journal of Pharmacology and Toxicology 2, no. 7 (2007): 660–65. http://dx.doi.org/10.3923/jpt.2007.660.665.

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Kulinich, T. M., Ya Yu Kiseleva, A. M. Shishkin, et al. "Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells." Sechenov Medical Journal 15, no. 2 (2024): 36–47. http://dx.doi.org/10.47093/2218-7332.2024.15.2.36-47.

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Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures.Materials and methods. We performed an in vitro study on CA125-positive human ovarian cancer cells (OVCAR-3, OVKATE) and CA125 negative cells (breast cancer MCF 7, embryonic kidney HEK293). Cytotoxic effects on tumor cells were evaluated after 0, 4, 8 and 24 hours using the 3’-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and

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MOHD AMIN, INDAH, NUR BATRISYIA RUSLAN, ZULINDA AYU ZULKIPLI, NURUL AILI ZAKARIA, MOHD TAUFIQ MAT JALIL, and FARIZAN ARIS. "CYTOTOXIC EFFECT OF DILLAPIOLE ON HUMAN BREAST CANCER MCF-7 CELLS." Malaysian Applied Biology 51, no. 4 (2022): 29–35. http://dx.doi.org/10.55230/mabjournal.v51i4.08.

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Plant secondary metabolites and their derivatives play a significant role in anticancer drug therapy since they are effective against specific characteristics while reducing side effects. Dillapiole is a phenylpropanoid that holds several bioactivities like anti-fungal, anti-inflammatory, anti-leishmanial, and anti-cancer. This study aims to investigate the possible cytotoxic effect of dillapiole on human breast cancer, MCF-7 cells. Cells were cultured in complete RPMI media and incubated at standard culture conditions. After the cells reached 80% confluency, cells were treated with various co

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Muflikhasari, Haruma Anggraini, Riris Istighfari Jenie, Ratna Asmah Susidarti, and Edy Meiyanto. "Growth Inhibitory Property of Pentagamavunone-0 (PGV-0) on 4T1 Cells under Stress Condition : 2D and 3D Culture Model." Indonesian Journal of Cancer Chemoprevention 10, no. 3 (2019): 149. http://dx.doi.org/10.14499/indonesianjcanchemoprev10iss3pp149-158.

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Pentagamavunone-0 (PGV-0), one of the curcumin analogue, is reported to have a cytotoxic effect on various cancer cells. This study aimed to explore the growth inhibitory effects of PGV-0 against highly-metastatic breast cancer, 4T1 cells under stress condition covering 2D and 3D speroid cytotoxic, anti-migration, and suppression of MMP-9. PGV-0 showed cytotoxic effects on 2D and 3D 4T1 cells with IC50value of 49 μM and 26 μM, respectively. In addition, PGV-0 performed anti-migratory effect. The single treatment at 25 μM PGV-0 and 50 μM showed inhibitory effect on cell migration by 54% and 51%

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Vignesh, M., S. Rajeshkumar, Anitha Roy, and T. Lakshmi. "Preparation of Herbal Formulation of Stevia and Piper Longum and its Antiinflammatory and Cytotoxic Effect." Journal of Complementary Medicine Research 13, no. 2 (2022): 87. http://dx.doi.org/10.5455/jcmr.2022.13.02.17.

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AIM: The aim of the study was to prepare the herbal formulation of stevia and the piper longum nanoparticle and to evaluate its anti-inflammatory and cytotoxic effects. Materials and Methods: For the evaluation of antiinflammatory activity we used albumin denaturation assay and for the cytotoxic activity we used a brine shrimp lethality assay and evaluated the result according to the test results and the graph was made with the results Result : The nanoparticle of stevia and piper longum showed a marked anti inflammatory and cytotoxic activity with increased in their concentrations Conclusion:

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Nurrachma, Marsya Yonna, Gergorius Gena Maran, Nindya Budiana Putri, et al. "Fingerroot (Boesenbergia pandurata) Extract Inhibits Proliferation and Migration of 4T1 Metastatic Breast Cancer Cells." Indonesian Journal of Cancer Chemoprevention 11, no. 3 (2020): 103. http://dx.doi.org/10.14499/indonesianjcanchemoprev11iss3pp103-114.

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Fingerroot (Boesenbergia pandurata) is an Indonesian herb, with anti-proliferation and anti-migratory effects against several cancer cells. This study aims to investigate the anticancer property of Fingerroot Extract (FE) in combination with doxorubicin (Dox) against 4T1, a metastatic breast cancer cell lines. FE was prepared by 96% ethanol maceration and characterized by thin-layer chromatography analysis. FE was subjected to a cytotoxicity test with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay alone or in combination with 10 nM Dox against 4T1 cells. Cytotoxic ef

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Abdel-Massih, Roula, Venicia Hawach, and Marie-Anne Boujaoude. "The Cytotoxic and Anti-proliferative Activity of High Molecular Weight Pectin and Modified Citrus Pectin." Functional Foods in Health and Disease 6, no. 9 (2016): 587. http://dx.doi.org/10.31989/ffhd.v6i9.270.

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Background: Pectin is a heterogeneous polysaccharide mainly present in citrus fruits and has different biological activities.Objective: High molecular weight Citrus Pectin and modified citrus pectin (MCP) were tested for their cytotoxic, anti-proliferative, and anti-oxidant activity.Methods: The cytotoxicity of pectin was studied against HaCaT cell line (human keratinocyte cell line) using Trypan blue method and LDH-cytotoxicity assay. Anti-proliferative activity was assayed using a WST-1 proliferation kit. Antioxidant activity was determined using the DPPH scavenging assay.Results: MCP and Pe

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Al-Ghazali, Linda. "The Anti-Candida and the Cytotoxic Activity of Aloe Vera Gel Extracts." Journal of Scientific Research in Medical and Biological Sciences 3, no. 4 (2022): 1–9. http://dx.doi.org/10.47631/jsrmbs.v3i4.559.

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Purpose: The research paper studies the in vitro anti-candida activity and cytotoxic effects of Aloe vera (Linn) leaves extract against melanoma and normal cell lines. Subjects and Methods: The traditional Soxhlet apparatus was used to prepare the crude plant extract using organic solvents. The agar well diffusion method was used to explore the in vitro anti-candida, and the MTT assay was used to assess the cytotoxic activity. Results: With IC50 values of 250 g/ml and more than 1000 g/ml, respectively, crude extract demonstrated anti-Candida activity against Candida ((kefyr, glabrata, and albi

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Leeuwenberg, J. F., H. Spits, W. J. Tax, and P. J. Capel. "Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies." Journal of Immunology 134, no. 6 (1985): 3770–75. http://dx.doi.org/10.4049/jimmunol.134.6.3770.

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Abstract The effects of monoclonal anti-T3 antibodies on the effector phase of cytotoxic T lymphocytes (CTL) were studied with respect to antigen-specific and antigen-nonspecific lysis of different target cells. Anti-T3 antibodies inhibited the antigen-specific lysis by CTL generated in mixed lymphocyte cultures (MLC), but they concomitantly augmented the nonspecific killing of third-party cells such as the cell lines Daudi, Raji, and K562. This nonspecific cytotoxicity was induced by various anti-T3 antibodies, whereas antibodies reactive with other antigens expressed on the cytotoxic effecto

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Kashyap, Arun Kumar, Padmini Bisoyi, and Buddhi Prakash Jain. "Antioxidant, Anti-Microbial, Anti-Inflammatory and Cytotoxic Effect of Macrotyloma Uniflorum Leaf Extract." Advances in Pharmacology and Pharmacy 11, no. 3 (2023): 179–86. http://dx.doi.org/10.13189/app.2023.110301.

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12

Han, Zhen, Shuo Liu, Hongsheng Lin, Anna Trivett, De Yang, and Joost J. Oppenheim. "The Curative Effect of Cryptotanshinone and anti-PD-L1 on Mouse Hepatocellular Carcinoma." Journal of Immunology 200, no. 1_Supplement (2018): 122.16. http://dx.doi.org/10.4049/jimmunol.200.supp.122.16.

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Abstract Cryptotanshinone (CT), isolated, purified and crystalized from the dried roots of Salvia militorrhiza, has been reported to have cytotoxic antitumor effects on a human liver cancer cell line in vitro. However, we have shown that CT also has immunoadjuvant effects and augments Th1 antitumor immunity. CT inhibited the proliferation of mouse hepatoma (Hepa1-6) cells by inducing Hepa1-6 cells apoptosis by dose dependent inhibition of the STAT3 signaling pathway. Furthermore, CT could also induce RAW264.7 cells polarize toward a M1 phenotype presumably with cytotoxic anti-tumor effects. CT

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Stitz, L., J. Baenziger, H. Pircher, H. Hengartner, and R. M. Zinkernagel. "Effect of rabbit anti-asialo GM1 treatment in vivo or with anti-asialo GM1 plus complement in vitro on cytotoxic T cell activities." Journal of Immunology 136, no. 12 (1986): 4674–80. http://dx.doi.org/10.4049/jimmunol.136.12.4674.

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Abstract The susceptibility of cytotoxic effector lymphocytes and their induction to in vivo or in vitro treatment with rabbit anti-neutral glycolipid ganglio-N-tetraosylceramide (anti-ASGM1) antiserum was investigated. Intravenous injection of anti-ASGM1 antiserum eliminated measurable natural killer (NK) cell activity in spleen cells of mice infected for 5 days with Vaccinia virus, or for 8 days with lymphocytic choriomeningitis virus (LCMV) if injected 24 hr prior to testing. In addition, this treatment lowered measurable virus-specific cytotoxic T cell activity by 60 to 95%. Virus-specific

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Zottel, Alja, Ivana Jovčevska, Neja Šamec, et al. "Anti-vimentin, anti-TUFM, anti-NAP1L1 and anti-DPYSL2 nanobodies display cytotoxic effect and reduce glioblastoma cell migration." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592091530. http://dx.doi.org/10.1177/1758835920915302.

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Background: Glioblastoma is a particularly common and very aggressive primary brain tumour. One of the main causes of therapy failure is the presence of glioblastoma stem cells that are resistant to chemotherapy and radiotherapy, and that have the potential to form new tumours. This study focuses on validation of eight novel antigens, TRIM28, nucleolin, vimentin, nucleosome assembly protein 1-like 1 (NAP1L1), mitochondrial translation elongation factor (EF-TU) (TUFM), dihydropyrimidinase-related protein 2 (DPYSL2), collapsin response mediator protein 1 (CRMP1) and Aly/REF export factor (ALYREF

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Tsumori, Michihiro, Junko Tanaka, Kunio Koshimura, Mikiko Kawaguchi, Yoshio Murakami, and Yuzuru Kato. "Cytotoxic effect of nitric oxide on human hematological malignant cells." Acta Biochimica Polonica 49, no. 1 (2002): 139–44. http://dx.doi.org/10.18388/abp.2002_3830.

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We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In sample

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Arena, Andrea, Maria Anele Romeo, Rossella Benedetti, et al. "New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects." Pharmaceuticals 14, no. 11 (2021): 1068. http://dx.doi.org/10.3390/ph14111068.

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Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines. We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlatio

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Aykac, Asli, Eda Becer, Tuğçe Balcı Okcanoğlu, Meryem Güvenir, Kaya Süer, and Seda Vatansever. "The Cytotoxic Effects of Humic Acid on Human Breast Cancer Cells." Proceedings 2, no. 25 (2018): 1565. http://dx.doi.org/10.3390/proceedings2251565.

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Breast cancer is the most common cancer among women and in order to create alternative treatments different types of in vivo and in vitro studies have used various plant-based therapeutic agents. Humic acid (HA) induces apoptosis and has various pharmacological properties including anti-inflammatory and anti-proliferative effects. In our study, we examined the cytotoxic effects of HA at concentrations of 5, 10, 20, 50 and 100 μg/mL in human breast adenocarcinoma MCF-7 cell line for 24 and 48 h. By using MTT method, it has been found out that HA 100 g/mL had cytotoxic effect on human breast ade

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Komatsu, Noriko, Miku Komatsu, Riuko Ohashi, et al. "Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma." Journal of Oncology 2020 (March 11, 2020): 1–8. http://dx.doi.org/10.1155/2020/9593516.

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Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide. The standard treatment of surgery, chemotherapy, and radiotherapy can result in long-term complications which lower the patient’s quality of life, such as eating disorders, speech problems, and disfiguring or otherwise untoward cosmetic issues. Antibody therapy against cancer-specific antigens is advantageous in terms of its lesser side effects achieved by its greater specificity, though the antitumor activity is still usually not enough to obtain a complete cure. Robo1, an axon guidance receptor, has re

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Widiyastuti, Yuli, Rarastoeti Pratiwi, Sugeng Riyanto, and Subagus Wahyuono. "Cytotoxic activity and apoptosis induction of avocado Persea americana Mill. seed extract on MCF-7 cancer cell line." Indonesian Journal of Biotechnology 23, no. 2 (2018): 61. http://dx.doi.org/10.22146/ijbiotech.32141.

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Avocado Persea Americana Mill. is a commercially important crop and studies have shown that the pulp may have benefits to cardiovascular health, dermatological health and possibly anti-cancer activity. Avocado seeds have several medicinal properties such as anti-hyperglycemic, antimicrobial, antioxidant and anti-inflammation. This study aim to evaluate the effect of avocado seed extract on viability and apoptosis of breast cancer cell line MCF-7. The anticancer effect was evaluated by cytotoxic test using MTT assay and the effect on apoptosis and cell cycle was examined by flow cytometry metho

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黄, 浓郁. "Synergistic Cytotoxic Effect of Anti-EGFR/Gelonin Immunotoxin Combined with Taxol Anti-Tumor Effects and Its Mechanism." World Journal of Cancer Research 04, no. 01 (2014): 4–9. http://dx.doi.org/10.12677/wjcr.2014.41002.

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Diaconescu, Bogdan Mihail, Daniela Jitaru, Mihaiela Loredana Dragos, et al. "The Effect of Some Natural Cytotoxic Peptides on Tumor Cells." Revista de Chimie 69, no. 3 (2018): 597–601. http://dx.doi.org/10.37358/rc.18.3.6157.

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Many studies have highlighted the anti-tumor properties of some natural peptides known to have antimicrobial virtues. In this study, we evaluated the tumoricidal potential of dermaseptin, defensin, cecropin A and B on tumor cell lines: M14K (human mesothelioma). The viability study was performed using PE V Annexin and 7-AAD (7-amino-actinomycin D) (BD Pharmingen). This test was used to detect and measure apoptosis by flow cytometry technique. The experimental results of our study revealed that the cytotoxic effects of the four peptides depend on their concentration. In this in vitro experiment

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Shaito, Abdullah A., Islam Omairi, Najlaa Al-Thani, et al. "Determination of Medicago orbicularis Antioxidant, Antihemolytic, and Anti-Cancerous Activities and Its Augmentation of Cisplatin-Induced Cytotoxicity in A549 Lung Cancer Cells." Plants 13, no. 3 (2024): 442. http://dx.doi.org/10.3390/plants13030442.

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The anti-lung cancer properties of the plant Medicago orbicularis have not been explored yet. Therefore, we identified its phytochemical composition and investigated the antioxidant, anti-hemolytic, and anti-cancerous properties of extracts of this plant in A549 human lung adenocarcinoma cells. The results show that all parts of M. orbicularis (stems, leaves, and fruits) exhibit remarkable hemolytic activities and modest antioxidant capacity. In addition, all extracts showed a dose-dependent anti-cancerous cytotoxic activity against A549 cells, with fruit extracts being the most potent. This c

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Francis, Twinkle, S. Rajeshkumar, Anita Roy, and T. Lakshmi. "Anti-inflammatory and Cytotoxic Effect of Arrow Root Mediated Selenium Nanoparticles." Pharmacognosy Journal 12, no. 6 (2020): 1363–67. http://dx.doi.org/10.5530/pj.2020.12.188.

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Mohanad Hasan Hussein, Zina Fawzi Al-Obaidi, Ahmed Sadoon Hassain, and Zainab Abbas Jaber. "Anti-oxidant and cytotoxic effect of collagen extracted from local buffalo." International Journal of Science and Technology Research Archive 6, no. 1 (2024): 037–41. http://dx.doi.org/10.53771/ijstra.2024.6.1.0109.

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This study about aimed to consider the DPPH radical scavenging recreation and cytotoxicity potentials of collagen extracted from buffalo. The result of antioxidant (DPPH) indicated that collagen possessed the ability to scavenge free in a concentrations dependant manner. They were (67.86±3.65, 54.44± 2.05, 47.92 ±0.53, 44.29±1.80 and 18.02±5.74%) for (200,100,50,25 and 12.5 mg\ml) respectively. the results of cytotoxicity assay match the antioxidant results, the cell viability decrease by concentrations increasing to be 40.20± 3.06, 48.64± 1.48, 61.57± 1.33, 71.14± 0.82 and 83.21± 1.10% for400

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Cybulska-Stopa, Bożena, Andrzej Gruchała, and Maciej Niemiec. "Immune-Related Pancytopenia Induced by Anti-PD-1 Therapy – Interrupt or Continue Treatment – The Role of Immunohistochemical Examination." Case Reports in Oncology 12, no. 3 (2019): 820–28. http://dx.doi.org/10.1159/000504130.

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Immune checkpoint inhibitors (ICIs), including anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA-4) and anti-programmed death receptor-1/ligand-1 (anti-PD-1/anti-PD-L1) caused a breakthrough in oncology and significantly improved therapeutic outcomes in cancer patients. ICIs generate a specific reaction in T cells, directed against antigens on cancer cells, leading to their damage and death. Through similar or the same antigens, activated lymphocytes may also have a cytotoxic effect on healthy cells, causing development of specific adverse effects – so-called immune-related adverse events (irAE

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Albaayit, Shaymaa Fadhel Abbas, Rukesh Maharjan, and Mariam Khan. "Evaluation of Hemolysis Activity of Zerumbone on RBCs and Brine Shrimp Toxicity." Baghdad Science Journal 18, no. 1 (2021): 0065. http://dx.doi.org/10.21123/bsj.2021.18.1.0065.

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Zerumbone is a well-known compound having anti-cancer, anti-ulcer, anti-inflammatory and anti-hyperglycemic effects. During its use for the disease treatment, the membrane of erythrocyte can be affected by consumption of this bioactive compound. The current study was the first report of investigation of the hemolytic activities on human erythrocytes and cytotoxic profile of zerumbone. The toxicity of zerumbone on human erythrocytes was determined by in vitro hemolytic assay. Brine shrimp lethality assay was used to evaluate the cytotoxic effect of zerumbone at concentrations 10, 100 and 1000 μ

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Bednarczyk-Cwynar, Barbara, Anna Leśków, Izabela Szczuka, Lucjusz Zaprutko, and Dorota Diakowska. "The Effect of Oleanolic Acid and Its Four New Semisynthetic Derivatives on Human MeWo and A375 Melanoma Cell Lines." Pharmaceuticals 16, no. 5 (2023): 746. http://dx.doi.org/10.3390/ph16050746.

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This study aimed to synthesize four new semisynthetic derivatives of natural oleanolic acid (OA) and, based on an analysis of their cytotoxic and anti-proliferative effects against human MeWo and A375 melanoma cell lines, select those with anti-cancer potential. We also screened the treatment time with the concentration of all four derivatives. We synthesized oxime 2 and performed its acylation with carboxylic acids into new derivatives 3a, 3b, 3c and 3d according to the methods previously described. Colorimetric MTT and SRB assays were used to measure the anti-proliferative and cytotoxic acti

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Bruning-Richardson, A., H. Sanganee, S. Barry, et al. "PL3.6 Targeting GSK-3 activity promotes mitotic catastrophe via centrosome destabilisation and enhances the effect of radiotherapy in glioma models." Neuro-Oncology 21, Supplement_3 (2019): iii4. http://dx.doi.org/10.1093/neuonc/noz126.009.

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Abstract BACKGROUND Targeting kinases as regulators of cellular processes that drive cancer progression is a promising approach to improve patient outcome in GBM management. The glycogen synthase kinase 3 (GSK-3) plays a role in cancer progression and is known for its pro-proliferative activity in gliomas. The anti-proliferative and cytotoxic effects of the GSK-3 inhibitor AZD2858 were assessed in relevant in vitro and in vivo glioma models to confirm GSK-3 as a suitable target for improved single agent or combination treatments. MATERIAL AND METHODS The immortalised cell line U251 and the pat

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Abílio, Gisely Maria Freire, Cicera Janaine Camilo, Henrique Douglas Melo Coutinho, et al. "Cytotoxic and Anti-HSV-1 Effects of Caulerpin Derivatives." Molecules 29, no. 16 (2024): 3859. http://dx.doi.org/10.3390/molecules29163859.

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Marine organisms represent a potential source of secondary metabolites with various therapeutic properties. However, the pharmaceutical industry still needs to explore the algological resource. The species Caulerpa lamouroux Forssk presents confirmed biological activities associated with its major compound caulerpin, such as antinociceptive, spasmolytic, antiviral, antimicrobial, insecticidal, and cytotoxic. Considering that caulerpin is still limited, such as low solubility or chemical instability, it was subjected to a structural modifications test to establish which molecular regions could

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Maryati, M., A. Saifudin, S. Wahyuni, et al. "Cytotoxic effect of Spirulina platensis extract and Ulva compressa Linn. on cancer cell lines." Food Research 4, no. 4 (2020): 1018–23. http://dx.doi.org/10.26656/fr.2017.4(4).389.

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Studies have shown that algae and seaweed have cytotoxic activity. This study was aimed to determine the cytotoxic activity of Spirulina platensis and Ulva compressa Linn. extracts against cancer cell lines. The cytotoxic activity of the extract was carried out using the MTT ((3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. Results showed that the ethanol extract and methanol extract of Spirulina platensis have no cytotoxic effect against HeLa, WiDr, MCF7 and T47D cells. Water extract of Spirulina platensis had no cytotoxic activity on T47D and Vero cells. Water extracts o

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Mukundh Chaithanya, V. "Anti-inflammatory and cytotoxic effect of lycopene and raspberry in-situ gel." Bioinformation 18, no. 7 (2022): 645–50. http://dx.doi.org/10.6026/97320630018645.

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Preparation of an in-situ gel containing lycopene and raspberry plant formulation and analysis of its anti-inflammatory and antioxidant effects is described. Lycopene is known for its anticancer and antioxidant activity. It induces apoptosis, thereby reducing the cancer cells, and also reduces the injury of cells due to oxidative activity. Similarly, raspberry also contains antioxidants properties which can help to reduce oxidative stress and chronic inflammation. This study includes extracts containing 25% of Raspberry and 10% lycopene, carboxymethyl cellulose, hydroxypropyl methyl cellulose,

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McCoy, Kathy D., Ian F. Hermans, J. Henry Fraser, Graham Le Gros, and Franca Ronchese. "Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8+ T Cells Independently of CD4+T Cell Help." Journal of Experimental Medicine 189, no. 7 (1999): 1157–62. http://dx.doi.org/10.1084/jem.189.7.1157.

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The mechanisms that regulate the strength and duration of CD8+ cytotoxic T cell activity determine the effectiveness of an antitumor immune response. To better understand the antitumor effects of anti-cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) antibody treatment, we analyzed the effect of CTLA-4 signaling on CD8+ T cells in vitro and in vivo. In vitro, cross-linking of CTLA-4 on purified CD8+ T cells caused decreased proliferative responses to anti-CD3 stimulation and rapid loss of activation marker expression. In vivo, blockade of CTLA-4 by neutralizing anti–CTLA-4 mAb greatly enhan

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Amar, Sabreen, Amr Helmy Mustafa El-Bolok, Sherif Farouk El-Gayar, and Maii Ibrahim Sholkamy. "Synergistic Cytotoxic Effect of Honey Bee Venom and Cisplatin on Tongue Squamous Cell Carcinoma Cell Line." Open Access Macedonian Journal of Medical Sciences 9, B (2021): 1739–44. http://dx.doi.org/10.3889/oamjms.2021.7672.

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BACKGROUND: Tongue cancer is one of the most common head and neck cancers in the world. Nowadays, natural compounds are important resources of many anti-cancer drugs. Venom from honey bees possesses potent anti-cancer activities. Cisplatin is a chemotherapeutic drug that has been used for decades to treat cancer cells. Recently, combination therapy has been a popular treatment choice for cancer patients. AIM: This study was conducted to evaluate the synergistic cytotoxic effect of honey bee venom (BV) and cisplatin on tongue squamous cell carcinoma 25 (SCC-25) cell lines. METHODS: The cytotoxi

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Patil, Ajit B., and Anilkumar J. Shinde. "Cytotoxic, apoptotic, and anti-inflammatory properties of Adenoon indicum leaf methanolic extract using HT29 cell lines." Bangladesh Journal of Pharmacology 19, no. 4 (2025): 122–27. https://doi.org/10.3329/bjp.v19i4.78705.

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In the present study, methanolic extract of Adenoon indicum leaves is investigated for its cytotoxic, apoptotic, and anti-inflammatory properties using HT29 cell lines. The extract yield was 1.6%. MTT assay of HT-29 cells shows that the extract's IC50 value was 80 μg/mL with 10 μg/mL for doxorubicin, confirming its cytotoxic effect. Flow cytometry analysis demonstrated that extract caused cell cycle arrest, with 2.3% of cells in the G2/M phase and 32.2% in the S phase at a dosage of 160 μg/mL. Propidium iodide/annexin V staining revealed that the extract caused 3.1% early apoptosis and 6.0% la

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Cristovão, André, Nelson Andrade, Fátima Martel, and Cláudia Silva. "Effect of Sodium-Glucose Co-Transporter 2 Inhibitors Combined with Metformin on Pancreatic Cancer Cell Lines." International Journal of Molecular Sciences 25, no. 18 (2024): 9932. http://dx.doi.org/10.3390/ijms25189932.

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Pancreatic cancer (PC) is the ninth-leading cause of cancer-related deaths worldwide. Diabetic patients have an increased risk and mortality rates for PC. Sodium-glucose co-transporter 2 (SGLT2) inhibitors and metformin (Met) are widely used anti-diabetic medications. Both Met and SGLT2 inhibitors have anticancer properties in PC, but nothing is known concerning their combined effect. So, we investigated the in vitro effect of SGLT2 inhibitors combined with Met. Canagliflozin and dapagliflozin possessed cytotoxic, antiproliferative, and pro-apoptotic properties in the tested PC cell lines. In

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Santiago-Cruz, José Angel, Araceli Posadas-Mondragón, Angélica Pérez-Juárez, et al. "In Vitro Evaluation of the Anti-Chikungunya Virus Activity of an Active Fraction Obtained from Euphorbia grandicornis Latex." Viruses 16, no. 12 (2024): 1929. https://doi.org/10.3390/v16121929.

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Chikungunya virus (CHIKV) is classified as a pathogen with the potential to cause a pandemic. This situation becomes more alarming since no approved drug exists to combat the virus. The present research aims to demonstrate the anti-CHIKV activity of molecules present in the latex of Euphorbia grandicornis. Therefore, a biodirected assay was carried out to find the molecules with anti-CHIKV activity. Extractions with hexane, dichloromethane, and methanol and subsequent purification by column chromatography were carried out to later evaluate cytotoxic activity by 3-(4,5-dimethyl-2-thiazolyl)-2,5

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Bagheri, Malihe, Amir Reza Hesari, Parisa Zia Sarabi, Hamid Reza Rahimi, Maryam Baazm, and Faezeh Ghasemi. "Antiproliferative Effect of Aspirin on Colorectal Cancer Cell Line." Iranian Journal of Toxicology 12, no. 5 (2018): 1–4. http://dx.doi.org/10.32598/ijt.12.5.474.1.

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Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Aspirin may have anticancer properties, and can be effective as a novel strategy for the treatment of colorectal cancer (CRC). The aim of this study was to assess the cytotoxic effects of Aspirin drug in CRC cell lines compared with Oxaliplatin drug in vitro. Methods: Cell viability was assessed after treatment of SW742 and SW480 cells with Aspirin and Oxaliplatin by MTT assay, and the amount of IC50 was determined. Statistical analysis was performed through one-way ANOVA and Tukey multiple range analysis (SPSS 19.0 software (P

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Jaradat, Nidal. "Phytochemical Profile and In Vitro Antioxidant, Antimicrobial, Vital Physiological Enzymes Inhibitory and Cytotoxic Effects of Artemisia jordanica Leaves Essential Oil from Palestine." Molecules 26, no. 9 (2021): 2831. http://dx.doi.org/10.3390/molecules26092831.

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Artemisia jordanica (AJ) is one of the folkloric medicinal plants and grows in the arid condition used by Palestinian Bedouins in the Al-Naqab desert for the treatment of diabetes and gastrointestinal infections. The current investigation aimed, for the first time, to characterize the (AJ) essential oil (EO) components and evaluate EO’s antioxidant, anti-obesity, antidiabetic, antimicrobial, anti-inflammatory, and cytotoxic activities. The gas chromatography-mass spectrometer (GC-MS) technique was utilized to characterize the chemical ingredients of (AJ) EO, while validated biochemical approac

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Panizo, Carlos, Susana Inoges, Ascensión López Díaz de Cerio, et al. "Immunotherapy with LAK Cells and Anti-CD20 Monoclonal Antibodies for Follicular Lymphoma: Enhanced Antibody-Dependent Cell Cytotoxicity of LAK Cells in Association with GA101 Rather Than Rituximab." Blood 120, no. 21 (2012): 4881. http://dx.doi.org/10.1182/blood.v120.21.4881.4881.

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Abstract Abstract 4881 Background The current gold standard treatment for follicular lymphoma (FL) consists in the association of rituximab, that is an anti-CD20 monoclonal antibody (mAb), and one among many possible chemotherapy regimens, followed by maintenance with the same mAb. However, LF is still considered incurable. Hence, it is necessary to keep investigating new strategies aiming at improving the overall clinical results. As an anti-tumor mechanism, antibody-dependent cellular cytotoxicity (ADCC) depends on both the immune system effector arm and the antibody structure. The culture o

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Galanty, Agnieszka, Paweł Zagrodzki, Joanna Gdula-Argasińska, et al. "A Comparative Survey of Anti-Melanoma and Anti-Inflammatory Potential of Usnic Acid Enantiomers—A Comprehensive In Vitro Approach." Pharmaceuticals 14, no. 9 (2021): 945. http://dx.doi.org/10.3390/ph14090945.

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Usnic acid (UA) is a chiral lichen metabolite with an interesting pharmacological profile. The aim of this study was to compare the anti-melanoma effect of (+)-UA and (−)-UA in an in vitro model by studying their impact on the cells as well as the processes associated with cancer progression. The effect of UA enantiomers on the viability, proliferation, and invasive potential of three melanoma cell lines (HTB140, A375, WM793) was evaluated. Their interaction with a chemotherapeutic drug—doxorubicin was assessed by isobolographic analysis. Anti-inflammatory and anti-tyrosinase properties of (+)

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Koňáriková, K., GM Girašková, I. Žitňanová, et al. "Biological Analyses of the Effects of TiO2 and PEG-b-PLA Nanoparticles on Three-Dimensional Spheroid-Based Tumor." Physiological Research 72, S3 (2023): S257—S266. http://dx.doi.org/10.33549/physiolres.935152.

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The aim of our study was to monitor the antiproliferative/ cytotoxic and genotoxic effects of both, poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) and titanium dioxide (TiO2) nanoparticles on the tumor (HT-29, MCF-7, U118MG) and healthy (HEK-293T) cell lines during 2D cultivation and during cultivation in the spheroid form (3D cultivation). Cells or spheroids were cultivated with nanoparticles (0.01, 0.1, 1, 10, 50, and 100 μg/ml) for 72 hours. The cytotoxic effect was determined by the MTT test and the genotoxic effect by the comet assay. We found that 2D cultivation of tumor cell

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Xu, Zengtao, Xiuping Chen, Zhangfeng Zhong, Lidian Chen, and Yitao Wang. "Ganoderma lucidum Polysaccharides: Immunomodulation and Potential Anti-Tumor Activities." American Journal of Chinese Medicine 39, no. 01 (2011): 15–27. http://dx.doi.org/10.1142/s0192415x11008610.

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Ganoderma lucidum (G. lucidum), a basidiomycete white rot fungus, has long been prescribed to prevent and treat various human diseases, particularly in China, Japan, and Korea. Several classes of bioactive substances have been isolated and identified from G. lucidum, such as triterpenoids, polysaccharides, nucleosides, sterols, and alkaloids, among others. This paper examines the potential role of G. lucidum polysaccharide (GLPS) in tumor therapy and the possible mechanisms involved. Both in vitro and in vivo studies suggested that the anti-tumor activities of GLPS are mediated by its immunomo

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Park, Hae-Bin, Juyoung Hwang, Wei Zhang, et al. "Polysaccharide from Codium fragile Induces Anti-Cancer Immunity by Activating Natural Killer Cells." Marine Drugs 18, no. 12 (2020): 626. http://dx.doi.org/10.3390/md18120626.

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Natural polysaccharides exhibit beneficial immune modulatory effects, including immune stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, and its effect on tumor-bearing mice. Intravenous CFP treatment of C57BL/6 mice resulted in the upregulation of CD69, which is a marker associated with NK cell activation. In addition, intracellular levels of interferon (IFN)-γ and the cytotoxic mediators perforin and granzyme B were markedly increased in response to the CFP treatment of splenic NK cells

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Greeshma G Nair та Sathianarayanan S. "Syzygium Samarangense : A Review on its Pharmacognostical, Pharmacological and Phytochemical Proৎile". International Journal of Research in Pharmaceutical Sciences 11, № 4 (2020): 6066–78. http://dx.doi.org/10.26452/ijrps.v11i4.3276.

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The objective of this review is to document briefly about the chemical constituents, pharmacognostical evaluation and biological activities of Syzygium samarangense belongs to the family Myrtaceae. It is generally called Java Apple, Wax Apple, Blume, Chambekka etc. Syzygium samarangense traditionally used as an astringent. It is also used to treat fever and halt diarrhea. The whole plant contains flavonoids, terpenoids, tannins, phenolic compounds, gallic acid, ellagic acid, squalene, botulin, lupeol, sitosterol, mixture of cycloartenol stearate, lupenyl stearate, β-sitosterol stearate, vitami

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Neelofar, Km, Jamshed Haneef, Jamal Ahmad, Khursheed Alam, and Rana Zaidi. "Anti-glycating and anti-cytotoxic effect of silibinin on albumin at early glycation: A physiochemical study." Archives of Biochemistry and Biophysics 753 (March 2024): 109916. http://dx.doi.org/10.1016/j.abb.2024.109916.

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Meiyanto, Edy, Herwandhani Putri, Yonika Arum Larasati, et al. "Anti-proliferative and Anti-metastatic Potential of Curcumin Analogue, Pentagamavunon-1 (PGV-1), Toward Highly Metastatic Breast Cancer Cells in Correlation with ROS Generation." Advanced Pharmaceutical Bulletin 9, no. 3 (2019): 445–52. http://dx.doi.org/10.15171/apb.2019.053.

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Purpose: Pentagamavunon-1 (PGV-1) is a curcumin analogue that shows cytotoxic activity in various cancer cells. In this study, we evaluated the effect of PGV-1 on a highly metastatic breast cancer cell line, the 4T1 cells, as an anti-metastatic and anti-proliferative agent. Methods: Cell viability was evaluated using MTT assay; while cell cycle profile, apoptosis incidence, and ROS intracellular level were determined by flow cytometry. Cell senescence was observed under senescence-associated-β-galactosidase (SA-β-gal) staining assay. The expression of matrixmetalloproteinase-9 (MMP-9) was dete

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Lee, Hyun-Su, and Gil-Saeng Jeong. "6,7,4′-Trihydroxyflavanone Prevents Methamphetamine-Induced T Cell Deactivation by Protecting the Activated T Cells from Apoptosis." American Journal of Chinese Medicine 49, no. 01 (2021): 95–111. http://dx.doi.org/10.1142/s0192415x21500051.

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Methamphetamine (METH) is an extremely addictive drug that has raised serious public health concerns recently. METH addiction not only results in neuronal cytotoxicity, but it also affects immune cell activity, including T lymphocytes. 6,4,7[Formula: see text]-trihydroxyflavanone (THF), isolated from Dalbergia odorifera, has been studied for its antibacterial activity, but evidence for whether THF has an anti-cytotoxic and protective effect on T cell activation exposed to METH is lacking. In this study, results showed that treatment with THF was not cytotoxic to Jurkat T cells but dose-depende

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Jagetia, Ganesh Chandra, and Shaival Kamalaksha Rao. "Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells." Evidence-Based Complementary and Alternative Medicine 3, no. 2 (2006): 267–72. http://dx.doi.org/10.1093/ecam/nel011.

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Extracts ofTinospora cordifolia(TCE) have been shown to possess anti-tumor properties, but the mechanism of the anti-tumor function of TCE is poorly understood. This investigation elucidates the possible mechanism underlying the cytotoxic effects of dichlormethane extracts of TCE, after selecting optimal duration and concentration for treatment. HeLa cells were exposed to various concentrations of TCE, which has resulted in a concentration-dependent decline in the clonogenicity, glutathione-S-transferase (GST) activity and a concentration-dependent increase in lipid peroxidation (TBARS) with a

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Joseph, Baby, P. Sankarganesh, Koji Ichiyama, and Naoki Yamamoto. "In vitrostudy on cytotoxic effect and anti-DENV2 activity ofCarica papayaL. leaf." Frontiers in Life Science 8, no. 1 (2014): 18–22. http://dx.doi.org/10.1080/21553769.2014.924080.

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Narvaez-Flores, Jessica, Gabriela Vilar-Pineda, Laura Acosta-Torres, and Rene Garcia-Contreras. "Cytotoxic and anti-inflammatory effects of chitosan and hemostatic gelatin in oral cell culture." Acta Odontológica Latinoamericana 34, no. 2 (2021): 98–103. http://dx.doi.org/10.54589/aol.34/2/098.

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Chitosan is a biopolymer with bactericidal/bacteriostatic effect, biocompatible and biodegradable. It has been used in tissue engineering to replace tissues partially or completely by releasing bioactive materials or influencing cell growth, usually in regenerative medicine and dentistry. The aim of this study was to evaluate the cytotoxic and anti-inflammatory effect of chitosan alone or with hemostatic gelatin (Spongostand®) in cultures of human pulp cells (HPC), human gingival fibroblasts (HGF) and mouse pre-osteoblasts (MC3T3-E1, ATCC). HPC and HGF were isolated from patients. Cells were s

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