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1

Yŏm, Yŏng-il. Chŏnsachʻe pʻŭropʻail ŭl iyong han hang tangnyo chagyong kijŏn kŏmjŭng yŏnʼgu =: Study of the action mechanism of anti-diabetic drugs by transcriptome profiling. Sikpʻum Ŭiyakpʻum Anjŏnchʻŏng, 2007.

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2

Canadian Coordinating Office for Health Technology Assessment., ed. Comparative clinical and budget evaluations of rosiglitazone and pioglitazone with other anti-diabetic agents. Canadian Coordinating Office for Health Technology Assessment, 2003.

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3

Pharm, Boucher Michel B., and Canadian Coordinating Office for Health Technology Assessment., eds. Efficacy of rosiglitazone and pioglitazone compared to other anti-diabetic agents: Systematic review and budget impact analysis. Canadian Coordinating Office for Health Technology Assessment, 2002.

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4

Pharm, Boucher Michel B., and Canadian Coordinating Office for Health Technology Assessment., eds. Efficacy of rosiglitazone and pioglitazone compared to other anti-diabetic agents: Systematic review and budget impact analysis. Canadian Coordinating Office for Health Technology Assessment, 2002.

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5

Medicinal Plants: Promising Future for Health and New Drugs. Taylor & Francis Group, 2018.

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6

Kuroedov, Alexey. Role of protein kinase C[beta] inhibitors and glycogen synthase kinase-3 inhibitors, new anti-diabetic drugs, in preventing atherogenic transformation of monocytes and endothelial activation. 2007.

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7

Li, Jie Jack. Laughing Gas, Viagra, and Lipitor. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780195300994.001.0001.

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The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us prob
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8

Ghani, Usman. Alpha-Glucosidase Inhibitors: Promising Candicates for Anti-Diabetic Drug Discovery. Elsevier, 2019.

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9

Ghani, Usman. Alpha-Glucosidase Inhibitors: Clinically Promising Candidates for Anti-Diabetic Drug Discovery. Elsevier, 2019.

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10

Jones, Roy W. Pharmacological treatment of dementia. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0038.

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This chapter summarises the available clinical evidence for specific pharmacological treatments for dementia with a particular emphasis on practical considerations and realistic expectations of currently available anti-dementia drugs. It covers the treatment of both cognitive and non-cognitive symptoms. The search for specific treatments for dementia has inevitably concentrated on Alzheimer’s disease (AD), partly because it is the commonest cause of dementia and partly because scientific progress has provided more potential therapeutic targets for AD than other dementias. AD is treated with AC
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11

Streijger, Femke, Ward T. Plunet, and Wolfram Tetzlaff. Ketogenic Diet and Ketones for the Treatment of Traumatic Brain and Spinal Cord Injury. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0016.

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Ketogenic diets (KD)—high in fat, adequate in protein, and very low in carbohydrates—were developed almost a century ago and are still used clinically for drug-resistant epilepsy and some rare metabolic disorders. Possible new indications for cancers, diabetes, obesity, and neurodegenerative disorders are being trialed in humans based on a growing body of preclinical data showing efficacy. However the underlying mechanisms of KD remain incompletely understood. This chapter focuses on the neuroprotective effects of KD after spinal cord injury (SCI) and traumatic brain injury (TBI), and discusse
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12

Dalbeth, Nicola. Gout. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0141.

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Gout is a common and treatable disorder of purine metabolism. Gout typically presents as recurrent self-limiting episodes of severe inflammatory arthritis affecting the foot. In the presence of persistent hyperuricaemia, tophi, chronic synovitis, and joint damage may develop. Diagnosis of gout is confirmed by identification of monosodium urate (MSU) crystals using polarizing light microscopy. Hyperuricaemia is the central biochemical cause of gout. Genetic variants in certain renal tubular urate transporters including SLC2A9 and ABCG2, and dietary factors including intake of high-purine meats
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13

Dalbeth, Nicola. Gout. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0141_update_003.

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Gout is a common and treatable disorder of purine metabolism. Gout typically presents as recurrent self-limiting episodes of severe inflammatory arthritis affecting the foot. In the presence of persistent hyperuricaemia, tophi, chronic synovitis, and joint damage may develop. Diagnosis of gout is confirmed by identification of monosodium urate (MSU) crystals using polarizing light microscopy. Hyperuricaemia is the central biochemical cause of gout. Genetic variants in certain renal tubular urate transporters including SLC2A9 and ABCG2, and dietary factors including intake of high-purine meats
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14

Balik, Martin. Perioperative cardiac care of the high-risk non-cardiac patient. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0076.

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Non-cardiac surgery conveys a cardiac risk related to the status of the patient’s cardiovascular system. Cardiac-related risk of surgery can be assessed by integrating the risk and urgency of the procedure with cardiovascular risk factors, which include age, ischaemic heart disease, heart failure, stroke, diabetes mellitus, chronic obstructive pulmonary disease, and renal dysfunction. An individual assessment can include simple multivariate scoring systems, developed with the aim of evaluating cardiac risk prior to non-cardiac surgery. Patient assessment can be extended for indicated additiona
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15

Balik, Martin. Perioperative cardiac care of the high-risk non-cardiac patient. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199687039.003.0076_update_001.

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Non-cardiac surgery conveys a cardiac risk related to the status of the patient’s cardiovascular system. Cardiac-related risk of surgery can be assessed by integrating the risk and urgency of the procedure with cardiovascular risk factors, which include age, ischaemic heart disease, heart failure, stroke, diabetes mellitus, chronic obstructive pulmonary disease, and renal dysfunction. An individual assessment can include simple multivariate scoring systems, developed with the aim of evaluating cardiac risk prior to non-cardiac surgery. Patient assessment can be extended for indicated additiona
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16

Balik, Martin. Perioperative cardiac care of the high-risk non-cardiac patient. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0076_update_002.

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Non-cardiac surgery conveys a cardiac risk related to the status of the patient’s cardiovascular system. Cardiac-related risk of surgery can be assessed by integrating the risk and urgency of the procedure with cardiovascular risk factors, which include age, ischaemic heart disease, heart failure, stroke, diabetes mellitus, chronic obstructive pulmonary disease, and renal dysfunction. An individual assessment can include simple multivariate scoring systems, developed with the aim of evaluating cardiac risk prior to non-cardiac surgery. Patient assessment can be extended for indicated additiona
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